keyword
MENU ▼
Read by QxMD icon Read
search

Head and neck molecular biology

keyword
https://www.readbyqxmd.com/read/28721019/inhibitors-of-the-pd-1-pd-l1-axis-for-the-treatment-of-head-and-neck-cancer-current-status-and-future-perspectives
#1
REVIEW
Xiongwen Ran, Kai Yang
Head and neck cancer (HNC) is a common malignant tumor, but traditional therapeutic methods have unsatisfactory curative effects and many complications occur. Hence, there is an urgent need to develop therapeutic methods that can elicit curative effects as well as low toxic and few side effects. With the development of cancer molecular biology and immunology, targeted therapy for immune checkpoints of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) has shown enormous development prospects for HNC treatment...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28705099/heat-induced-brca2-degradation-in-human-tumors-provides-rationale-for-hyperthermia-parp-inhibitor-combination-therapies
#2
Nathalie van den Tempel, Hanny Odijk, Netteke van Holthe, Kishan Naipal, Anja Raams, Berina Eppink, Dik van Gent, Jose Hardillo, Gerda Verduijn, Jan Drooger, Gerard van Rhoon, Dineke Smedts, Helena van Doorn, Joost Boormans, Agnes Jager, Martine Franckena, Roland Kanaar
PURPOSE: Hyperthermia (40-44°C) effectively sensitizes tumors to radiotherapy by locally altering tumor biology. One of the effects of heat at the cellular level is inhibition of DNA repair by homologous recombination via degradation of the BRCA2-protein. This suggests that hyperthermia can expand the group of patients that benefit from PARP-inhibitors, a drug exploiting homologous recombination deficiency. Here, we explore whether the molecular mechanisms that cause heat-mediated degradation of BRCA2 are conserved in cell lines from various origins and, most importantly, whether, BRCA2 protein levels can be attenuated by heat in freshly biopted human tumors...
July 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28678827/identifying-novel-genes-and-biological-processes-relevant-to-the-development-of-cancer-therapy-induced-mucositis-an-informative-gene-network-analysis
#3
Cielito C Reyes-Gibby, Stephanie C Melkonian, Jian Wang, Robert K Yu, Samuel A Shelburne, Charles Lu, Gary Brandon Gunn, Mark S Chambers, Ehab Y Hanna, Sai-Ching J Yeung, Sanjay Shete
Mucositis is a complex, dose-limiting toxicity of chemotherapy or radiotherapy that leads to painful mouth ulcers, difficulty eating or swallowing, gastrointestinal distress, and reduced quality of life for patients with cancer. Mucositis is most common for those undergoing high-dose chemotherapy and hematopoietic stem cell transplantation and for those being treated for malignancies of the head and neck. Treatment and management of mucositis remain challenging. It is expected that multiple genes are involved in the formation, severity, and persistence of mucositis...
2017: PloS One
https://www.readbyqxmd.com/read/28675017/-analysis-of-the-current-status-of-research-on-human-papillomavirus-associated-head-and-neck-cancers-based-on-recent-chinese-literature
#4
Liu Yan, Cao Mingxin, Wu Jiashun, Gao Xiaolei, Liang Xinhua
OBJECTIVE: To analyze the current status of research on human papillomavirus (HPV)-associated head and neck cancers in China using national and international references. METHODS: We searched for bibliographies in the electronic databases of Sichuan University, including Chinese Biological and Medical Database (CBM), China Science and Technology Journal Database (VIP), and Wanfang Journal Database. Then, data was selected and extracted to analyze the basic characteristics of HPV-related head and neck cancers, the general prevalence of HPV, and the effects of various clinic pathological indicators on HPV patients...
June 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28664935/mutually-exclusive-recurrent-kras-and-map2k1-mutations-in-rosai-dorfman-disease
#5
Sofia Garces, L Jeffrey Medeiros, Keyur P Patel, Shaoying Li, Sergio Pina-Oviedo, Jingyi Li, Juan C Garces, Joseph D Khoury, C Cameron Yin
Rosai-Dorfman disease is a histiocytic disorder with a poorly defined pathogenesis. Recent molecular studies have revealed recurrent mutations involving genes in the MAPK/ERK pathway in Langerhans cell histiocytosis and Erdheim-Chester disease. However, cases of Rosai-Dorfman disease have rarely been assessed. We performed next-generation sequencing to assess 134 genes on 21 cases of Rosai-Dorfman disease, including 13 women and 8 men with a median age of 43 years (range, 3-82). In all, 13 had extranodal, 5 had nodal, and 3 had coexistent nodal and extranodal disease...
June 30, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28643759/overall-treatment-duration-with-multimodality-treatment-approach-and-outcome-results-in-oral-cavity-carcinoma-a-study-from-an-institute-from-central-india
#6
Vandana Jain, Digpal Dharkar, Hamsa Nandini, Shailendra M Jain
OBJECTIVE OF THE STUDY: To see the different age groups, gender, sites, disease stage, treatment outcome of various oral cavity sites carcinoma by combined modalities and the overall treatment duration. MATERIALS AND METHODS: A total of 212 oral cavity carcinoma patients (169 males and 43 females) with complete records (from September 2009 to December 2012) were analyzed for age, sex, histopathology, associated medical illnesses, various subsites with disease stage, various treatment modalities with the duration and follow-up records for disease control as well as disease failure at local, nodal, local + nodal, and distant metastasis...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28613101/targeting-igf1r-pathway-in-cancer-with-micrornas-how-close-are-we
#7
Arathy S Kumar, Suresh K Rayala, Ganesh Venkatraman
Cancer of the head and neck are the most common cancers in India and account for 30% of all cancers. At molecular level, it could be attributed to the over-expression of growth factors like IGF1-R, EGFR, VEGF-R and deregulation of cell cycle regulators and tumor suppressors. IGF1-R is an emerging target in head and neck cancer treatment, because of its reported role in tumor development, progression and metastasis. IGF1R targeted agents are in advanced stages of clinical development. Nevertheless, these agents suffer from several disadvantages including acquired resistance and toxic side effects...
June 14, 2017: RNA Biology
https://www.readbyqxmd.com/read/28588149/tumor-metabolic-features-identified-by-fdg-pet-correlates-with-gene-networks-of-immune-cell-microenvironment-in-head-and-neck-cancer
#8
Kwon Joong Na, Hongyoon Choi
The importance of FDG PET in imaging head and neck squamous cell carcinoma (HNSCC) has grown in recent decades. Since PET has prognostic values, and provides functional and molecular information in HNSCC, the genetic and biologic backgrounds associated with PET parameters are of great interests. Here, as a systems biology approach, we aimed to investigate gene networks associated with tumor metabolism and their biological function using RNA sequence and FDG PET data. Methods: Using RNA sequence data of HNSCC downloaded from TCGA data portal, we constructed gene coexpression network...
June 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28579578/the-t-box-transcription-factor-3-in-development-and-cancer
#9
Tarryn Willmer, Aretha Cooper, Jade Peres, Rehana Omar, Sharon Prince
T-box factors comprise an archaic family of evolutionary conserved transcription factors that regulate patterns of gene expression essential for embryonic development. The T-box transcription factor 3 (TBX3), a member of this family, is expressed in several tissues and plays critical roles in, among other structures, the heart, mammary gland and limbs and haploinsufficiency of the human TBX3 gene is the genetic basis for the autosomal dominant disorder, ulnar-mammary syndrome. Overexpression of TBX3 on the other hand has been linked to several cancers including melanoma, breast, pancreatic, liver, lung, head and neck, ovarian, bladder carcinomas and a number of sarcoma subtypes...
June 4, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28578852/radioactive-iodine-therapy-molecular-imaging-and-serum-biomarkers-for-differentiated-thyroid-cancer-2017-guidelines-of-the-french-societies-of-nuclear-medicine-endocrinology-pathology-biology-endocrine-surgery-and-head-and-neck-surgery
#10
Slimane Zerdoud, Anne-Laure Giraudet, Sophie Leboulleux, Laurence Leenhardt, Stéphane Bardet, Jérôme Clerc, Marie-Elisabeth Toubert, Abir Al Ghuzlan, Pierre-Jean Lamy, Claire Bournaud, Isabelle Keller, Frédéric Sebag, Renaud Garrel, Eric Mirallié, Lionel Groussin, Elif Hindié, David Taïeb
No abstract text is available yet for this article.
July 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28531899/epidemiology-and-molecular-biology-of-head-and-neck-cancer
#11
Adriana Jou, Jochen Hess
Head and neck cancer is a common and aggressive malignancy with a high morbidity and mortality profile. Although the large majority of cases resemble head and neck squamous cell carcinoma (HNSCC), the current classification based on anatomic site and tumor stage fails to capture the high level of biologic heterogeneity, and appropriate clinical management remains a major challenge. Hence, a better understanding of the molecular biology of HNSCC is urgently needed to support biomarker development and personalized care for patients...
2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28513565/epidermal-growth-factor-receptor-cell-proliferation-signaling-pathways
#12
REVIEW
Ping Wee, Zhixiang Wang
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer, glioblastoma, head and neck cancer, pancreatic cancer, and breast cancer. Various mechanisms mediate the upregulation of EGFR activity, including common mutations and truncations to its extracellular domain, such as in the EGFRvIII truncations, as well as to its kinase domain, such as the L858R and T790M mutations, or the exon 19 truncation...
May 17, 2017: Cancers
https://www.readbyqxmd.com/read/28503090/compounds-from-celastraceae-targeting-cancer-pathways-and-their-potential-application-in-head-and-neck-squamous-cell-carcinoma-a-review
#13
REVIEW
Camila Hernandes, Ana Maria Soares Pereira, Patricia Severino
Squamous cell carcinoma of the head and neck is one of the most common cancer types worldwide. It initiates on the epithelial lining of the upper aerodigestive tract, at most instances as a consequence of tobacco and alcohol consumption. Treatment options based on conventional therapies or targeted therapies under development have limited efficacy due to multiple genetic alterations typically found in this cancer type. Natural products derived from plants often possess biological activities that may be valuable in the development of new therapeutic agents for cancer treatment...
February 2017: Current Genomics
https://www.readbyqxmd.com/read/28474265/gene-expression-signatures-for-head-and-neck-cancer-patient-stratification-are-results-ready-for-clinical-application
#14
REVIEW
Luca Tonella, Marco Giannoccaro, Salvatore Alfieri, Silvana Canevari, Loris De Cecco
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer by incidence worldwide and considering the recent EUROCARE-5 population-based study the 5-year survival rate of HNSCC patients in Europe ranges between 69% in localized cases and 34% in patients with regional involvement. The development of high-throughput gene expression assays in the last two decades has provided the invaluable opportunity to improve our knowledge on cancer biology and to identify predictive signatures in the most deeply analyzed malignancies, such as hematological and breast cancers...
May 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28407653/differential-pattern-of-hif-1%C3%AE-expression-in-hnscc-cancer-stem-cells-after-carbon-ion-or-photon-irradiation-one-molecular-explanation-of-the-oxygen-effect
#15
Anne-Sophie Wozny, Alexandra Lauret, Priscillia Battiston-Montagne, Jean-Baptiste Guy, Michael Beuve, Micaela Cunha, Yannick Saintigny, Emilie Blond, Nicolas Magne, Philippe Lalle, Dominique Ardail, Gersende Alphonse, Claire Rodriguez-Lafrasse
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) are resistant to standard treatments, partly due to cancer stem cells (CSCs) localised in hypoxic niches. Compared to X-rays, carbon ion irradiation relies on better ballistic properties, higher relative biological effectiveness and the absence of oxygen effect. Hypoxia-inducible factor-1α (HIF-1α) is involved in the resistance to photons, whereas its role in response to carbon ions remains unclear. METHODS: Two HNSCC cell lines and their CSC sub-population were studied in response to photons or carbon ion irradiation, in normoxia or hypoxia, after inhibition or not of HIF-1α...
May 9, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28405244/clusterization-in-head-and-neck-squamous-carcinomas-based-on-lncrna-expression-molecular-and-clinical-correlates
#16
Pelayo G de Lena, Abel Paz-Gallardo, Jesús M Paramio, Ramón García-Escudero
BACKGROUND: Long non-coding RNAs (lncRNAs) have emerged as key players in a remarkably variety of biological processes and pathologic conditions, including cancer. Next-generation sequencing technologies and bioinformatics procedures predict the existence of tens of thousands of lncRNAs, from which we know the functions of only a handful of them, and very little is known in cancer types such as head and neck squamous cell carcinomas (HNSCCs). RESULTS: Here, we use RNAseq expression data from The Cancer Genome Atlas (TCGA) and various statistic and software tools in order to get insight about the lncRNome in HNSCC...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28351566/micrornas-in-human-tongue-squamous-cell-carcinoma-from-pathogenesis-to-therapeutic-implications
#17
REVIEW
Omer Faruk Karatas, Muhammet Oner, Alican Abay, Ali Diyapoglu
Being one of the most aggressive cancers of oral cavity, tongue squamous cell carcinoma (TSCC) constitutes 41% of all oral carcinomas. Despite considerable improvements in multimodal diagnosis and treatment techniques, TSCC still remains to be one of the most lethal cancer types in the head and neck region. MicroRNAs are endogenously synthesized, small, non-coding RNAs, which are responsible for post-transcriptional regulation of mRNA expression. They are involved in regulation of almost all biological processes through their spatial and temporal expression...
April 2017: Oral Oncology
https://www.readbyqxmd.com/read/28325958/micrornas-involvement-in-radioresistance-of-head-and-neck-cancer
#18
REVIEW
Parwez Ahmad, Jiri Sana, Marek Slavik, Pavel Slampa, Pavel Smilek, Ondrej Slaby
Resistance to the ionizing radiation is a current problem in the treatment and clinical management of various cancers including head and neck cancer. There are several biological and molecular mechanisms described to be responsible for resistance of the tumors to radiotherapy. Among them, the main mechanisms include alterations in intracellular pathways involved in DNA damage and repair, apoptosis, proliferation, and angiogenesis. It has been found that regulation of these complex processes is often controlled by microRNAs...
2017: Disease Markers
https://www.readbyqxmd.com/read/28325255/mucosal-melanoma-of-the-head-and-neck
#19
REVIEW
Paolo Antonio Ascierto, Remo Accorona, Gerardo Botti, Davide Farina, Piero Fossati, Gemma Gatta, Helen Gogas, Davide Lombardi, Roberto Maroldi, Piero Nicolai, Marco Ravanelli, Vito Vanella
Mucosal melanoma of the head and neck is a very rare and aggressive malignancy with a very poor prognosis. The nasal cavity, paranasal sinuses, and oral cavity are the most common locations. One-, 3- and 5-year survival rates between 2000 and 2007 were 63%, 30% and 20%, respectively. Cigarette smoking seems to be a risk factor even though the evidence for this is very low. Clinical signs and symptoms are usually nonspecific. While surgery is considered the mainstay of treatment for most mucosal melanomas of the head and neck region, radiotherapy has a role in local control of the disease after surgery...
April 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28270740/repression-of-gprc5a-is-associated-with-activated-stat3-which-contributes-to-tumor-progression-of-head-and-neck-squamous-cell-carcinoma
#20
Shuli Liu, Dongxia Ye, Tong Wang, Wenzheng Guo, Hongyong Song, Yueling Liao, Dongliang Xu, Hanguang Zhu, Zhiyuan Zhang, Jiong Deng
BACKGROUND: G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with pathologic differentiation grade of oral squamous cell carcinomas (OSCC) and overexpression of GPRC5A gene inhibited the malignant phenotype in OSCC cells, suggesting that GPRC5A also functions as a tumor suppressor in oral cancer. However, the molecular mechanisms underlying GPRC5A deficiency in head and neck squamous cell carcinoma (HNSCC) are still unclear...
2017: Cancer Cell International
keyword
keyword
37943
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"