keyword
MENU ▼
Read by QxMD icon Read
search

Head and neck molecular biology

keyword
https://www.readbyqxmd.com/read/27919336/tissue-reactions-to-ionizing-radiation-oral-mucosa
#1
Sylvia Gruber, Wolfgang Dörr
Radiotherapy is one of the most effective treatment strategies for solid malignancies, including head-and-neck tumors (HNT). Oral mucositis is the most frequent, often dose-limiting early adverse event of radio(chemo)therapy for HNT. The oral mucosal response is - like that of typical turnover tissues - based on radiation-induced impairment of epithelial proliferation and cell production, in face of ongoing physiological cell differentiation and cell loss, consequently resulting in hypoplasia and eventually mucosal ulceration...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27895714/early-detection-and-personalized-treatment-in-oral-cancer-the-impact-of-omics-approaches
#2
REVIEW
Ilda Patrícia Ribeiro, Leonor Barroso, Francisco Marques, Joana Barbosa Melo, Isabel Marques Carreira
BACKGROUND: Oral cancer is one of the most common malignant lesions of the head and neck. This cancer is an aggressive and lethal disease with no significant improvements in the overall survival in the last decades. Moreover, the incidence of oral HPV-positive tumors is rising, especially in young people. This oral neoplasm develops through numerous molecular imbalances that affect key genes and signaling pathways; however, the molecular mechanisms involved in the pathogenesis and progression of oral tumors are still to be fully determined...
2016: Molecular Cytogenetics
https://www.readbyqxmd.com/read/27891452/clinical-utility-of-serum-homocysteine-and-folate-as-tumor-markers-in-oral-squamous-cell-carcinoma-a-cross-sectional-study
#3
Sridhar Reddy Erugula, Mahesh Kumar Kandukuri, Prasanna M Danappanavar, Kranti Kiran Reddy Ealla, Surekha Velidandla, Sangameshwar Manikya
INTRODUCTION: Oral Squamous Cell Carcinoma (OSCC) is a common malignancy involving head and neck. Identifying the markers of molecular levels or biochemical markers involving the various metabolic reactions associated with the initiation and biological behavior of individual tumors are very important in diagnosis and prognosis. AIM: To measure and compare the levels of serum Homocysteine (Hcy) and serum folate in OSCC patients, smoking group and healthy subjects and also to assess the clinical utility of serum Hcy as a potential tumor marker in OSCC...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27877135/metabolomics-of-head-and-neck-cancer-a-mini-review
#4
REVIEW
Jae M Shin, Pachiyappan Kamarajan, J Christopher Fenno, Alexander H Rickard, Yvonne L Kapila
Metabolomics is used in systems biology to enhance the understanding of complex disease processes, such as cancer. Head and neck cancer (HNC) is an epithelial malignancy that arises in the upper aerodigestive tract and affects more than half a million people worldwide each year. Recently, significant effort has focused on integrating multiple "omics" technologies for oncological research. In particular, research has been focused on identifying tumor-specific metabolite profiles using different sample types (biological fluids, cells and tissues) and a variety of metabolomic platforms and technologies...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27863568/molecular-imaging-and-precision-medicine-in-head-and-neck-cancer
#5
REVIEW
Esther Mena, Shwetha Thippsandra, Anusha Yanamadala, Siddaling Redy, Puskar Pattanayak, Rathan M Subramaniam
The concept of using tumor genomic profiling information has revolutionized personalized cancer treatment. Head and neck (HN) cancer management is being influenced by recent discoveries of activating mutations in epidermal growth factor receptor and related targeted therapies with tyrosine kinase inhibitors, targeted therapies for Kristen Rat Sarcoma, and MET proto-oncogenes. Molecular imaging using PET plays an important role in assessing the biologic behavior of HN cancer with the goal of delivering individualized cancer treatment...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27837212/-preclinical-models-in-head-and-neck-tumors-evaluation-of-cellular-and-molecular-resistance-mechanisms-in-the-tumor-microenvironment
#6
A Affolter, J Hess
Because head and neck squamous cell carcinomas (HNSCC) are characterized by a distinct intertumorigenic and intratumorigenic heterogeneity, they often show substantial differences in the response to established therapy strategies. At present, a multitude of biologics and new pharmacological compounds for targeted therapies are available that allow more efficient and less toxic treatment. There is increasing pressure to establish predictive assays not only for ex ante analysis of the individual patient response to combined chemoradiotherapy and targeted therapies but also for investigation of the efficacy of new drugs...
December 2016: HNO
https://www.readbyqxmd.com/read/27802187/long-noncoding-rnas-in-head-and-neck-cancer
#7
Xiuhua Li, Yongbing Cao, Xiaojian Gong, Hongjiao Li
Head and neck cancers (HNCs) include a series of malignant tumors arising in epithelial tissues, typically oral cancer, laryngeal cancer, nasopharynx cancer and thyroid cancer. HNCs are important contributors to cancer incidence and mortality, leading to approximately 225,100 new patients and 77,500 deaths in China every year. Determination of the mechanisms of HNC carcinogenesis and progression is an urgent priority in HNC treatment. Long noncoding RNAs (lncRNAs) are noncoding RNAs longer than 200 bps. lncRNAs have been reported to participate in a broad scope of biological processes, and lncRNA dysregulation leads to diverse human diseases, including cancer...
October 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27779251/non-targeted-transcriptomic-effects-upon-thyroid-irradiation-similarity-between-in-field-and-out-of-field-responses-varies-with-tissue-type
#8
Britta Langen, Nils Rudqvist, Johan Spetz, John Swanpalmer, Khalil Helou, Eva Forssell-Aronsson
Non-targeted effects can induce responses in tissues that have not been exposed to ionizing radiation. Despite their relevance for risk assessment, few studies have investigated these effects in vivo. In particular, these effects have not been studied in context with thyroid exposure, which can occur e.g. during irradiation of head and neck tumors. To determine the similarity between in-field and out-of-field responses in normal tissue, we used a partial body irradiation setup with female mice where the thyroid region, the thorax and abdomen, or all three regions were irradiated...
October 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27754332/tetrandrine-induces-apoptosis-of-human-nasopharyngeal-carcinoma-npc-tw-076-cells-through-reactive-oxygen-species-accompanied-by-an-endoplasmic-reticulum-stress-signaling-pathway
#9
Ya-Jing Lin, Shu-Fen Peng, Meng-Liang Lin, Chao-Lin Kuo, Kung-Wen Lu, Ching-Lung Liao, Yi-Shih Ma, Fu-Shin Chueh, Kuo-Ching Liu, Fu-Shun Yu, Jing-Gung Chung
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the head and neck and the incidence is higher in Southeast Asia. Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid, a natural product, and exhibits biological activities including action against many human cancer cell lines. However, the molecular mechanism of TET-induced cell apoptosis in human NPC cells is still unclear. In the present study, we investigated TET-induced apoptotic cell death and associated possible signal pathways on human nasopharyngeal carcinoma NPC-TW 076 cells in vitro...
October 12, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27748661/nasopharyngeal-carcinoma-understanding-its-molecular-biology-at-a-fine-scale
#10
Prosenjit Paul, Himangshu Deka, Arup K Malakar, Binata Halder, Supriyo Chakraborty
Among all cancers, the incidence of nasopharyngeal carcinoma (NPC) is quite high in the endemic regions. NPC is a head and neck cancer with poor survival rate, and is rare throughout most of the world but common in certain geographic areas, like southern Asia and some regions of North East India (Nagaland, Manipur, and Mizoram). A clear understanding of its etiology is still lacking, but NPC is widely suspected to be the result of both genetic susceptibility and exposure to environmental factors or Epstein-Barr virus infection...
September 29, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27699528/molecular-patterns-and-biology-of-hpv-associated-hnscc
#11
Ruud H Brakenhoff, Steffen Wagner, Jens P Klussmann
Head and neck cancer is the sixth most common cancer worldwide. The large majority are squamous cell carcinomas (HNSCC) that develop in the mucosal linings of the upper aerodigestive tract. These tumors develop either by exogenous carcinogen exposure (smoking, alcohol drinking) or by human papillomavirus (HPV) infection, particularly those in the oropharynx (OPSCC). HPV-positive (HPV+ve) and HPV-negative (HPV-ve) OPSCC are considered different disease entities. HPV+ve tumors are different at the molecular level and likely as a consequence have a much more favorable prognosis than HPV-ve tumors, despite their generally advanced stage at presentation...
2017: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27636353/fusion-proteins-in-head-and-neck-neoplasms-clinical-implications-genetics-and-future-directions-for-targeting
#12
Derek A Escalante, He Wang, Christopher E Fundakowski
Fusion proteins resulting from chromosomal rearrangements are known to drive the pathogenesis of a variety of hematological and solid neoplasms such as chronic myeloid leukemia and non-small-cell lung cancer. Efforts to elucidate the role they play in these malignancies have led to important diagnostic and therapeutic triumphs, including the famous development of the tyrosine kinase inhibitor dasatinib targeting the BCR-ABL fusion. Until recently, there has been a paucity of research investigating fusion proteins harbored by head and neck neoplasms...
August 15, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27575972/human-papillomavirus-as-a-favorable-prognostic-factor-in-a-subset-of-head-and-neck-squamous-cell-carcinomas-a-meta-analysis
#13
Hongwei Liu, Jintao Li, Yubai Zhou, Qin Hu, Yi Zeng, Mohammadzad Mehryar Mohammadreza
Many epidemical and biological studies have proposed that human papillomavirus (HPV), primarily high-risk HPV16/18, is an etiological factor for a subset of head and neck (HN) cancers. On that premise, we systematically reviewed relevant articles and improved the understanding of HPV-related cancers. This article comprehensively described the characteristics of HPV-associated HN tumors according to demography, histopathology, molecular biology, and prognosis. Meta-analyses were conducted to combine the studies that reported the association between HPV status and these variables using Rev Man 5...
August 30, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27530596/molecular-markers-for-x-ray-insensitive-differentiated-cells-in-the-inner-and-outer-regions-of-the-mesenchymal-space-in-planarian-dugesia-japonica
#14
Machiko Teramoto, Tomomi Kudome-Takamatsu, Osamu Nishimura, Yang An, Makoto Kashima, Norito Shibata, Kiyokazu Agata
Planarian's strong regenerative ability is dependent on stem cells (called neoblasts) that are X-ray-sensitive and proliferative stem cells. In addition to neoblasts, another type of X-ray-sensitive cells was newly identified by recent research. Thus, planarian's X-ray-sensitive cells can be divided into at least two populations, Type 1 and Type 2, the latter corresponding to planarian's classically defined "neoblasts". Here, we show that Type 1 cells were distributed in the outer region (OR) immediately underneath the muscle layer at all axial levels from head to tail, while the Type 2 cells were distributed in a more internal region (IR) of the mesenchymal space at the axial levels from neck to tail...
September 2016: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/27527216/hpv-associated-head-and-neck-cancer
#15
REVIEW
Tara Spence, Jeff Bruce, Kenneth W Yip, Fei-Fei Liu
Head and neck cancers (HNCs) are a highly heterogeneous group of tumours that are associated with diverse clinical outcomes. Recent evidence has demonstrated that human papillomavirus (HPV) is involved in up to 25% of HNCs; particularly in the oropharyngeal carcinoma (OPC) subtype where it can account for up to 60% of such cases. HPVs are double-stranded DNA viruses that infect epithelial cells; numerous HPV subtypes, including 16, 18, 31, 33, and 35, drive epithelial cell transformation and tumourigenesis...
2016: Cancers
https://www.readbyqxmd.com/read/27514316/combined-modality-therapy-for-thoracic-and-head-and-neck-cancers-a-review-of-updated-literature-based-on-a-consensus-meeting
#16
Pierfrancesco Franco, Alba Fiorentino, Francesco Dionisi, Michele Fiore, Silvia Chiesa, Stefano Vagge, Francesco Cellini, Luciana Caravatta, Mario Tombolini, Fiorenza De Rose, Icro Meattini, Gianluca Mortellaro, Giuseppina Apicella, Lorenza Marino, Daniela Greto
PURPOSE: Combined modality therapy is a mainstay option for thoracic malignancies and head and neck cancers. The integration of different strategies is based on the multidisciplinary approach of modern clinical oncology. Radiation oncologists have to be educated, trained, and updated to provide state-of-the-art care to cancer patients and thus educational meetings are crucial. METHODS: The Italian Association of Radiation Oncology Young Members Working Group (AIRO Giovani) organized its 8th national meeting, focused on combination therapy in lung, esophageal, and head and neck cancer (with a specific focus on larynx-preservation strategies for larynx/hypopharynx tumors), involving young professionals working in Italy...
October 13, 2016: Tumori
https://www.readbyqxmd.com/read/27486476/interferon-gamma-induced-apoptosis-of-head-and-neck-squamous-cell-carcinoma-is-connected-to-indoleamine-2-3-dioxygenase-via-mitochondrial-and-er-stress-associated-pathways
#17
Siraj M El Jamal, Erin B Taylor, Zakaria Y Abd Elmageed, Abdulhadi A Alamodi, Denis Selimovic, Abdulaziz Alkhateeb, Matthias Hannig, Sofie Y Hassan, Simeon Santourlidis, Paul L Friedlander, Youssef Haikel, Srinivasan Vijaykumar, Emad Kandil, Mohamed Hassan
BACKGROUND: Tumor response to immunotherapy is the consequence of a concerted crosstalk between cytokines and effector cells. Interferon gamma (IFNγ) is one of the common cytokines coordinating tumor immune response and the associated biological consequences. Although the role of IFNγ in the modulation of tumor immunity has been widely documented, the mechanisms regulating IFNγ-induced cell death, during the course of immune therapy, is not described in detail. RESULTS: IFNγ triggered apoptosis of CLS-354 and RPMI 2650 cells, enhanced the protein expression and activation of indoleamine 2,3-dioxygenase (IDO), and suppressed the basal expression of heme oxygenase-1(HO-1)...
2016: Cell Division
https://www.readbyqxmd.com/read/27450723/asct2-slc1a5-is-an-egfr-associated-protein-that-can-be-co-targeted-by-cetuximab-to-sensitize-cancer-cells-to-ros-induced-apoptosis
#18
Haiquan Lu, Xinqun Li, Yang Lu, Songbo Qiu, Zhen Fan
Therapeutic targeting of ASCT2, a glutamine transporter that plays a major role in glutamine uptake in cancer cells, is challenging because ASCT2 also has a biological role in normal tissues. In this study, we report our novel finding that ASCT2 is physically associated in a molecular complex with epidermal growth factor receptor (EGFR), which is often overexpressed in human head and neck squamous cell carcinoma (HNSCC). Furthermore, we found that ASCT2 can be co-targeted by cetuximab, an EGFR antibody approved for treating metastatic HNSCC...
October 10, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27442865/the-molecular-landscape-of-recurrent-and-metastatic-head-and-neck-cancers-insights-from-a-precision-oncology-sequencing-platform
#19
Luc G T Morris, Raghu Chandramohan, Lyndsay West, Ahmet Zehir, Debyani Chakravarty, David G Pfister, Richard J Wong, Nancy Y Lee, Eric J Sherman, Shrujal S Baxi, Ian Ganly, Bhuvanesh Singh, Jatin P Shah, Ashok R Shaha, Jay O Boyle, Snehal G Patel, Benjamin R Roman, Christopher A Barker, Sean M McBride, Timothy A Chan, Snjezana Dogan, David M Hyman, Michael F Berger, David B Solit, Nadeem Riaz, Alan L Ho
Importance: Recurrent and/or metastatic head and neck cancer is usually incurable. Implementation of precision oncology for these patients has been limited by incomplete understanding of the molecular alterations underlying advanced disease. At the same time, the molecular profiles of many rare head and neck cancer types are unknown. These significant gaps in knowledge need to be addressed to rationally devise new therapies. Objective: To illuminate the distinct biology of recurrent and metastatic head and neck cancers and review implementation of precision oncology for patients with advanced disease...
July 21, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27417648/the-predictive-value-of-early-assessment-after-1-cycle-of-induction-chemotherapy-with-18f-fdg-pet-ct-and-diffusion-weighted-mri-for-response-to-radical-chemoradiotherapy-in-head-and-neck-squamous-cell-carcinoma
#20
Kee H Wong, Rafal Panek, Liam Welsh, Dualta Mcquaid, Alex Dunlop, Angela Riddell, Iain Murray, Yong Du, Sue Chua, Dow-Mu Koh, Shreerang Bhide, Chris Nutting, Wim J G Oyen, Kevin Harrington, Kate L Newbold
: The objective of this study was to assess the predictive value of early assessment (after 1 cycle of induction chemotherapy [IC]) with (18)F-FDG PET/CT and diffusion-weighted (DW) MRI for subsequent response to radical chemoradiotherapy in locally advanced head and neck squamous cell carcinoma (HNSCC). METHODS: Twenty patients with stage III-IVa HNSCC prospectively underwent (18)F-FDG PET/CT and DW MRI before and 2 wk after each cycle of IC (first cycle, IC1; second cycle, IC2)...
December 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
keyword
keyword
37943
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"