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https://www.readbyqxmd.com/read/27908766/mechanisms-and-predictors-of-recurrent-tachycardia-following-catheter-ablation-for-d-transposition-of-the-great-arteries-after-the-mustard-or-senning-operation
#1
Roberto G Gallotti, Himani Madnawat, Kevin M Shannon, Jamil A Aboulhosn, Farnoosh Nik-Ahd, Jeremy P Moore
BACKGROUND: The Senning and Mustard operations for DTGA are associated with a heightened risk for supraventricular tachycardia. Catheter ablation has been shown to be acutely successful for achieving rhythm control in this population, but the mechanisms of recurrence are ill-defined. OBJECTIVES: We hypothesized that the type and degree of recurrence would vary by the surgical technique employed. METHODS: All consecutive catheter ablation procedures for DTGA after Mustard/Senning operation between 2004 and 2016 at a single center were reviewed...
November 28, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27892741/impact-of-prenatal-diagnosis-of-transposition-of-the-great-arteries-on-postnatal-outcome
#2
P Domínguez-Manzano, I Herraiz, A Mendoza, J M Aguilar, D Escribano, B Toral, E Gómez-Montes, A Galindo
OBJECTIVE: To assess the impact of prenatal diagnosis of transposition of the great arteries (TGA) on postnatal outcome. METHODS: 154 patients with either simple (n = 101) or complex forms (n = 53) of TGA, diagnosed prenatally (G1, n = 88) or postnatally (G2, n = 66), who were admitted and underwent surgical correction in our centre between 1998 and 2014, were analysed. RESULTS: Prostaglandin E1 (PgE1) infusion and balloon atrial septostomy (BAS) were performed in the first 48 hours after birth more commonly in G1...
November 28, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27885445/limited-ventricular-preload-is-the-main-reason-for-reduced-stress-reserve-after-atrial-baffle-repair
#3
Andreas Eicken, Julia Michel, Alfred Hager, Daniel Tanase, Harald Kaemmerer, Julie Cleuziou, John Hess, Peter Ewert
The atrial baffle repair (ABR) significantly improved the fate of patients with transposition of the great arteries (TGA). However, these patients show impaired exercise tolerance and some present severe decline of systemic ventricular function. Intrinsic myocardial weakness, low heart rate response to exercise and diastolic filling impairment are discussed to be causative. Forty-nine long-term survivors with TGA (median age 23.7 year) after ABR were catheterized with measured oxygen consumption in four conditions (baseline, volume, atrial pacing, dobutamine) and the results were compared to 10 normal controls...
November 24, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27881809/situs-inversus-totalis-single-stage-anatomic-repair-of-complex-congenital-heart-disease
#4
Andrew C Chatzis, Alexandros J Tsoutsinos, Meletios A Kanakis, Constantinos A Contrafouris, Spyros Rammos, Fotios A Mitropoulos
Transposition of the great arteries occurs rarely in patients with mirror image dextrocardia and situs inversus, while the combination with severe coarctation of the descending aorta (CoA) makes the anatomy even more unusual. Therefore, it is not surprising that a case with such unusual and complicated anatomy presents unique problems when a primary definitive correction is attempted. We report a patient with situs inversus totalis and complex congenital heart disease including transposition of the great arteries and severe CoA who underwent successful complete, single-stage, anatomic correction...
November 23, 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27878634/relationship-between-habitual-exercise-and-performance-on-cardiopulmonary-exercise-testing-differs-between-children-with-single-and-biventricular-circulations
#5
Michael L O'Byrne, Sanyukta Desai, Megan Lane, Michael McBride, Stephen Paridon, Elizabeth Goldmuntz
Increasing habitual exercise has been associated with improved cardiopulmonary exercise testing (CPET) performance, specifically maximal oxygen consumption in children with operatively corrected congenital heart disease. This has not been studied in children following Fontan palliation, a population in whom CPET performance is dramatically diminished. A single-center cross-sectional study with prospective and retrospective data collection was performed that assessed habitual exercise preceding a clinically indicated CPET in children and adolescents with Fontan palliation, transposition of the great arteries following arterial switch operation (TGA), and normal cardiac anatomy without prior operation...
November 23, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27873373/cardiac-output-and-blood-flow-redistribution-in-the-fetus-with-d-loop-transposition-of-the-great-arteries-and-intact-ventricular-septum-insights-into-the-pathophysiology
#6
Max E Godfrey, Kevin G Friedman, Monika Drogosz, Abraham M Rudolph, Wayne Tworetzky
OBJECTIVES: Although the postnatal physiology of D-loop transposition of the great arteries with intact ventricular septum (DTGA-IVS) is well established, little is known about fetal DTGA-IVS. In the normal fetus, the pulmonary valve (PV) is larger than the aortic valve (AoV), there is exclusive right to left flow at the foramen ovale (FO) and ductus arteriosus (DA), and the left ventricle (LV) ejects 40% of combined ventricular output (CVO) through the aorta, primarily to the brain. In DTGA-IVS, the LV ejects O2 -rich blood to the pulmonary artery, theoretically leading to pulmonary vasodilation, increased branch pulmonary arterial flow and reduced DA flow...
November 22, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27860182/from-tricuspid-to-double-orifice-morphology-percutaneous-tricuspid-regurgitation-repair-with-the-mitraclip-device-in-congenitally-corrected-transposition-of-great-arteries
#7
Fabien Picard, Victor-Xavier Tadros, Anita W Asgar
Edge to edge transcatheter mitral valve repair with MitraClip (Abbott Vascular, Menlo Park, CA) is increasing for high-risk surgical patients with significant mitral regurgitation. Patients with congenitally corrected transposition of the great arteries (CCTGA) presenting with tricuspid valve regurgitation of a systemic right ventricle may represent particularly challenging candidates for MitraClip given their anatomy. We report the case of a 67-year-old gentleman with CCTGA and severe tricuspid regurgitation who was referred for MitraClip implantation after heart team consensus...
November 10, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27851293/1658-late-complications-of-d-transposition-of-the-great-arteries-status-post-mustard-procedure
#8
Khushbu Patel, Bishnu Subedi, Kumudha Ramasubbu
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847084/severe-two-vessel-ostial-stenosis-of-the-main-coronary-arteries-in-a-patient-with-transposition-of-the-great-arteries-after-an-arterial-switch-operation
#9
Krzysztof W Michalak, Konrad Szymczyk, Jadwiga A Moll, Jacek J Moll
No abstract text is available yet for this article.
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27843189/sonographic-diagnosis-of-transposition-of-great-arteries-in-mid-trimester-our-experience
#10
D S Grewal, Vikram Khanna, Sudhir Saxena, S C Chamoli
No abstract text is available yet for this article.
October 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27824140/random-mutagenesis-of-the-hyperthermophilic-archaeon-pyrococcus-furiosus-using-in-vitro-mariner-transposition-and-natural-transformation
#11
Natalia Guschinskaya, Romain Brunel, Maxime Tourte, Gina L Lipscomb, Michael W W Adams, Philippe Oger, Xavier Charpentier
Transposition mutagenesis is a powerful tool to identify the function of genes, reveal essential genes and generally to unravel the genetic basis of living organisms. However, transposon-mediated mutagenesis has only been successfully applied to a limited number of archaeal species and has never been reported in Thermococcales. Here, we report random insertion mutagenesis in the hyperthermophilic archaeon Pyrococcus furiosus. The strategy takes advantage of the natural transformability of derivatives of the P...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27821535/copy-number-variation-as-a-genetic-basis-for-heterotaxy-and-heterotaxy-spectrum-congenital-heart-defects
#12
Jason R Cowan, Muhammad Tariq, Chad Shaw, Mitchell Rao, John W Belmont, Seema R Lalani, Teresa A Smolarek, Stephanie M Ware
Genomic disorders and rare copy number abnormalities are identified in 15-25% of patients with syndromic conditions, but their prevalence in individuals with isolated birth defects is less clear. A spectrum of congenital heart defects (CHDs) is seen in heterotaxy, a highly heritable and genetically heterogeneous multiple congenital anomaly syndrome resulting from failure to properly establish left-right (L-R) organ asymmetry during early embryonic development. To identify novel genetic causes of heterotaxy, we analysed copy number variants (CNVs) in 225 patients with heterotaxy and heterotaxy-spectrum CHDs using array-based genotyping methods...
December 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27818476/congenitally-corrected-transposition-of-the-great-arteries-and-situs-inversus-in-an-octogenarian-with-systemic-right-ventricular-failure
#13
Mikio Shiba, Shigefumi Fukui, Hideo Ohuchi, Jin Ueda, Akihiro Tsuji, Yoshiaki Morita, Aya Miyazaki, Takeshi Ogo, Satoshi Yasuda, Isao Shiraishi, Norifumi Nakanishi
Systemic right ventricular (RV) failure in patients with congenitally corrected transposition of the great arteries (ccTGA), a major cause of mortality in the long-term follow-up, is usually induced by concomitant severe morphologically tricuspid regurgitation (TR) with/without Ebstein's anomaly or progressive conduction tissue disturbances. However, whether or not myocardial fibrosis is a common cause of systemic RV failure in patients with ccTGA remains unclear. Here, we describe an 82-year-old man who had been diagnosed previously as having uncomplicated ccTGA and situs inversus and recently developed systemic RV failure, which was neither associated with severe TR nor advanced conduction tissue abnormalities...
November 4, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27806817/total-cavopulmonary-connection-for-functionally-single-ventricle-without-cardiopulmonary-bypass-support
#14
Sohail Khan Bangash, Iqbal Hussain Pathan, Saad Bader Zaki
A heart with two atriums but one ventricle, an anatomy with a unique physiology, is responsible for many creative surgical and interventional approaches in history. Different surgical techniques have been used to address this strange physiology of parallel circulation. All these attempts met with failure till the concept of Fontan circulation was described. Currently, controversy exists between multistage vs. single stage total cavopulmonary connections. Total cavopulmonary connection is the only definitive procedure performed to provide palliation for patients with complex congenital heart defects which cannot support a biventricular circulation...
October 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27801971/twenty-five-year-survival-for-aboriginal-and-caucasian-children-with-congenital-heart-defects-in-western-australia-1980-to-2010
#15
Wendy N Nembhard, Jenny Bourke, Helen Leonard, Luke Eckersley, Jingyun Li, Carol Bower
BACKGROUND: Australian Aboriginal children have increased infant and childhood mortality compared with Caucasian children, but their mortality related to congenital heart defects (CHDs) throughout life is unknown. METHODS: We conducted a retrospective cohort study using data on 8,110 live born, singleton infants with CHDs born January 1980 to December 2010 from the Western Australian Register of Developmental Anomalies. Vital status was determined from death and medical records...
November 1, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27801691/sudden-cardiac-death-in-transposition-of-the-great-arteries-with-a-mustard-or-senning-baffle-the-myocardial-ischemia-hypothesis
#16
Paul Khairy
PURPOSE OF REVIEW: The literature on sudden death in transposition of the great arteries (D-TGA) with atrial switch surgery is reviewed and a pathophysiological mechanism is proposed. RECENT FINDINGS: Over 80% of sudden deaths in patients with D-TGA and Mustard or Senning baffles occur during exercise. Factors most consistently associated with ventricular arrhythmias and sudden death include heart failure parameters and atrial arrhythmias. Atrial arrhythmias have been observed to trigger malignant ventricular arrhythmias...
January 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/27798056/computational-modelling-for-congenital-heart-disease-how-far-are-we-from-clinical-translation
#17
REVIEW
Giovanni Biglino, Claudio Capelli, Jan Bruse, Giorgia M Bosi, Andrew M Taylor, Silvia Schievano
Computational models of congenital heart disease (CHD) have become increasingly sophisticated over the last 20 years. They can provide an insight into complex flow phenomena, allow for testing devices into patient-specific anatomies (pre-CHD or post-CHD repair) and generate predictive data. This has been applied to different CHD scenarios, including patients with single ventricle, tetralogy of Fallot, aortic coarctation and transposition of the great arteries. Patient-specific simulations have been shown to be informative for preprocedural planning in complex cases, allowing for virtual stent deployment...
October 25, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27797947/the-evolution-of-line-1-in-vertebrates
#18
Stéphane Boissinot, Akash Sookdeo
The abundance and diversity of the LINE-1 (L1) retrotransposon differ greatly among vertebrates. Mammalian genomes contain hundred of thousands L1s that have accumulated since the origin of mammals. A single group of very similar elements is active at a time in mammals, thus a single lineage of active families has evolved in this group. In contrast, non-mammalian genomes (fish, amphibians, reptiles) harbor a large diversity of concurrently transposing families, which are all represented by very small number of recently inserted copies...
October 19, 2016: Genome Biology and Evolution
https://www.readbyqxmd.com/read/27785879/intravascular-and-hybrid-intraoperative-stent-placement-for-baffle-obstruction-in-transposition-of-the-great-arteries-after-atrial-switch
#19
Joseph T Poterucha, Nathaniel W Taggart, Jonathan N Johnson, Bryan C Cannon, Allison K Cabalka, Donald J Hagler, Joseph A Dearani, Frank Cetta
OBJECTIVES: To report our experience with intravascular and hybrid intra-operative stent placement for baffle obstruction in patients with complete transposition of the great arteries (TGA) after the atrial switch (Mustard/Senning) operation. BACKGROUND: Venous baffle obstruction is a challenging complication after atrial switch operation in patients with TGA. Traditional treatment options include intravascular stenting or surgery. METHODS: A retrospective analysis of Mayo Clinic's electronic medical record was completed to identify consecutive pediatric and adult patients with TGA after atrial switch who underwent baffle stent implantation from 1994 to 2015...
October 27, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27777298/management-of-systemic-right-ventricular-failure-in-patients-with-congenitally-corrected-transposition-of-the-great-arteries
#20
Aleksei A Filippov, Pedro J Del Nido, Nikolay V Vasilyev
In recent decades, significant progress has been made in the diagnosis and management of congenitally corrected transposition of the great arteries (ccTGA). Nevertheless, gradual dysfunction and failure of the right ventricle (RV) in the systemic circulation remain the main contributors to mortality and disability for patients with ccTGA, especially after adolescence. Anatomic repair of ccTGA effectively resolves the problem of failure of the systemic RV and has good early and midterm results. However, this strategy is applicable primarily in infants and children up to their teens and has associated risks and limitations, and new challenges can arise in the late postoperative period...
October 25, 2016: Circulation
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