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https://www.readbyqxmd.com/read/29792664/tricolor-white-light-emitting-carbon-dots-with-multiple-cores-shell-structure-for-wled-application
#1
Tianyi Zhang, Feifei Zhao, Li Li, Bin Qi, Dongxia Zhu, Jianhua Lü, Changli Lü
The past few years have witnessed the rapid development of carbon dots (CDs) due to their outstanding optical properties and a wide range of applications. However, the design and control of CDs with long-wavelength and multicolor emission are still huge challenges to be addressed for their practical use in different fields. Here, novel nitrogen doped multiple-cores@shell structured CDs with tricolor emissions of red, green and blue were constructed via one pot hydrothermal method from citric acid (CA) and 5-amino-1,10-phenanthroline (Aphen) as reactants and the growth process of CDs was monitored with the reaction time in the synthetic system...
May 24, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29790574/investigations-on-velvet-regulatory-mutants-confirm-the-role-of-host-tissue-acidification-and-secretion-of-proteins-in-the-pathogenesis-of-botrytis-cinerea
#2
Nathalie Müller, Michaela Leroch, Julia Schumacher, David Zimmer, Anne Könnel, Klaus Klug, Thomas Leisen, David Scheuring, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Matthias Hahn
The Botrytis cinerea VELVET complex regulates light-dependent development and virulence. The goal of this study was to identify common virulence defects of several VELVET mutants and to reveal their molecular basis. Growth, differentiation, physiology, gene expression and infection of fungal strains were analyzed, and quantitative comparisons of in planta transcriptomes and secretomes were performed. VELVET mutants showed reduced release of citric acid, the major acid secreted by the wild-type, whereas no significant role for oxalic acid was observed...
May 23, 2018: New Phytologist
https://www.readbyqxmd.com/read/29788892/inhibition-of-glycolysis-and-glutaminolysis-emerging-drug-discovery-approach-to-combat-cancer
#3
Nicholas S Akins, Tanner C Nielson, Hoang V Le
Cancer cells have a very different metabolism from that of normal cells from which they are derived. Their metabolism is elevated, which allows them to sustain higher proliferative rate and resist some cell death signals. This phenomenon, known as the "Warburg effect", has become the focus of intensive efforts in the discovery of new therapeutic targets and new cancer drugs. Both glycolysis and glutaminolysis pathways are enhanced in cancer cells. While glycolysis is enhanced to satisfy the increasing energy demand of cancer cells, glutaminolysis is enhanced to provide biosynthetic precursors for cancer cells...
May 22, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29787795/anti-allergy-and-anti-tussive-activity-of-clitoria-ternatea-l-in-experimental-animals
#4
Niraj Kumar Singh, Debapriya Garabadu, Priyanka Sharma, Sushant Kumar Shrivastava, Pradeep Mishra
ETHNOPHARMACOLOGICAL RELEVANCE: Clitoria ternatea flower is traditionally used in the treatment of respiratory disorders including bronchitis and is one of the ingredients in different Ayurvedic preparations that are used in respiratory disorders. However, till date there is no scientific report on the anti-asthmatic activity of this flower. AIM OF THE STUDY: Ethanolic extract of Clitoria ternatea flowers (ECT) was evaluated for its anti-allergy and anti-tussive potential in experimental animals...
May 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29787679/dynamic-proteome-alteration-and-functional-modulation-of-human-saliva-induced-by-dietary-chemosensory-stimuli
#5
Matthias Bader, Andreas Dunkel, Mareike Wenning, Bernd Kohler, Guillaume Medard, Estela Del Castillo, Amin Gholami, Bernhard Kuster, Siegfried Scherer, Thomas Hofmann
Saliva flow measurements and SDS-PAGE separation of human whole saliva freshly collected after oral stimulation with citric acid (sour), aspartame (sweet), iso-α-acids (bitter), mono sodium L-glutamate (umami), NaCl (salty), 6-gingerol (pungent), hydroxy-α-sanshool (tingling), and hydroxy-β-sanshool (numbing), followed by tryptic digestion, nano-HPLC-MS/MS, and label-free protein quantitation demonstrated a stimulus- and time-dependent influence of the dietary chemosensates on salivation and the salivary proteome composition...
May 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29786843/effect-of-canning-and-freezing-on-the-nutritional-content-of-apricots
#6
Erin Claire Adkison, William B Biasi, Veronique Bikoba, Dirk M Holstege, Elizabeth J Mitcham
The effect of commercial canning and freezing on the nutritional content of fresh apricots was investigated. Processed samples were analyzed post-processing and after 3 months of storage and compared directly to fresh apricots from the same source. Vitamin C, beta-carotene, total phenols, and antioxidants were quantified. Compared to fresh, canned apricots initially exhibited similar levels of antioxidants, a 17% increase in beta-carotene, and a 48% increase in phenols, while vitamin C was reduced by 37%. After 3 months of storage, antioxidant levels were 47% higher than fresh...
May 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29785949/-the-functions-of-yhcz-gene-during-bacillus-thuringiensis-growth
#7
Lin da Jia, Tan Tan Gao, Qi Peng, Jing Lv, Jie Zhang, Min Chen, Fu Ping Song
yhcZ and yhcY genes constitute a two-component system in Bacillus subtilis and B. cereus that regulates bacterial growth. However, the exact biological function of yhcZ gene in B. thuringiensis has not been fully elucidated. In this study, we proved that HD73_5824 is an yhcZ gene in B. thuringiensis subsp. kurstaki HD73 strain by combining gene functional annotation, analysis of upstream and downstream genes arrangement, and amino acid sequence alignment. This yhcZ gene may co-regulate bacterial growth with HD73_5825 gene (yhcY gene) by constituting a two-component system...
May 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29785586/suicide-by-plastic-bag-suffocation-combined-with-the-mixture-of-citric-acid-and-baking-soda-in-an-adolescent
#8
Keishu Murakami, Takashi Kawaguchi, Yumiko Hashizume, Kengo Kitamura, Misato Okada, Kohei Okumoto, Shoich Sakamoto, Yuko Ishida, Mizuho Nosaka, Akihiko Kimura, Akihiro Takatsu, Toshikazu Kondo
We describe a case of suicidal asphyxiation using a plastic bag combined with carbon dioxide (CO2 ) gas. A 20-year-old male, whose head was covered with a plastic bag, was found dead in his room. In the plastic bag, there were two glass-made cups containing liquid-like substance. Through crime scene investigation by police staffs, a bottle of citric acid and a box of baking soda were also discovered in his room. The forensic autopsy revealed that there were neither lesions nor injuries in all of the organs...
May 22, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29785040/archetypal-transcriptional-blocks-underpin-yeast-gene-regulation-in-response-to-changes-in-growth-conditions
#9
David Talavera, Christopher J Kershaw, Joseph L Costello, Lydia M Castelli, William Rowe, Paul F G Sims, Mark P Ashe, Chris M Grant, Graham D Pavitt, Simon J Hubbard
The transcriptional responses of yeast cells to diverse stresses typically include gene activation and repression. Specific stress defense, citric acid cycle and oxidative phosphorylation genes are activated, whereas protein synthesis genes are coordinately repressed. This view was achieved from comparative transcriptomic experiments delineating sets of genes whose expression greatly changed with specific stresses. Less attention has been paid to the biological significance of 1) consistent, albeit modest, changes in RNA levels across multiple conditions, and 2) the global gene expression correlations observed when comparing numerous genome-wide studies...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784367/one-step-synthesis-of-fluorescent-carbon-dots-for-sensitive-and-selective-detection-of-hyperin
#10
Lizhen Liu, Zhi Mi, Qin Hu, Caiqing Li, Xiaohua Li, Feng Feng
In this article, we presented a new rapid, sensitive and selective method for the determination of hyperin (Hyp) based on the fluorescence quenching of fluorescent carbon dots (CDs). The CDs were prepared by simply mixing an aqueous solution of citric acid with diphosphorus pentoxide. This one-step synthetic route is fast and simple with neither high temperature nor complicated synthesis steps is involved. When Hyp was added to CDs solution, the fluorescence intensity of the CDs significantly decreased. The CDs display high selectivity for Hyp over many potentially interfering substances...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784329/health-and-taste-related-compounds-in-strawberries-under-various-irrigation-regimes-and-bio-stimulant-application
#11
Burcak Kapur, Mehmet Ali Sarıdaş, Eser Çeliktopuz, Ebru Kafkas, Sevgi Paydaş Kargı
Strawberry has a unique status within the fruit species in terms of health and taste related compounds. This experimental study concerned the application of a bio-stimulant at various drip irrigation levels (IR125, IR100, IR75 and IR50). The effects of the bio-stimulant (seaweed extract) on the eating quality, i.e., the taste-related (TSS, fructose, glucose, sucrose and citric, malic, l-ascorbic acid), and health-related (antioxidant activity, total phenol, myricetin and quercetin) compounds were studied in two strawberry cultivars...
October 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29783879/effects-of-sodium-citrate-citric-acid-and-lactic-acid-on-human-blood-coagulation
#12
Vittorio Scaravilli, Luca Di Girolamo, Eleonora Scotti, Mattia Busana, Osvaldo Biancolilli, Patrizia Leonardi, Andrea Carlin, Caterina Lonati, Mauro Panigada, Antonio Pesenti, Alberto Zanella
INTRODUCTION: Citric acid infusion in extracorporeal blood may allow concurrent regional anticoagulation and enhancement of extracorporeal CO2 removal. Effects of citric acid on human blood thromboelastography and aggregometry have never been tested before. METHODS: In this in vitro study, citric acid, sodium citrate and lactic acid were added to venous blood from seven healthy donors, obtaining concentrations of 9 mEq/L, 12 mEq/L and 15 mEq/L. We measured gas analyses, ionized calcium (iCa++ ) concentration, activated clotting time (ACT), thromboelastography and multiplate aggregometry...
May 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29778877/an-insight-into-the-multi-scale-structures-and-pasting-behaviors-of-starch-following-citric-acid-treatment
#13
Yinqiang Huo, Binjia Zhang, Meng Niu, Caihua Jia, Siming Zhao, Qilin Huang, Hongying Du
Using combined analytical techniques, this work discloses how citric acid (CA) treatment affects the pasting features of starch from a view of multi-scale structural evolutions. The treatment induced disruption events in starch multi-level structures and thus modulated the pasting behaviors. A structure-property relationship was proposed to rationalize CA effects on starch pasting properties. Specifically, CA disrupted starch structures from molecular scale to micron scale, eventually reducing pasting temperature and paste viscosities...
May 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29777964/protection-of-gnrh-analogue-by-chitosan-dextran-sulfate-nanoparticles-for-intravaginal-application-in-rabbit-artificial-insemination
#14
L Casares-Crespo, P Fernández-Serrano, M P Viudes-de-Castro
The present study was designed to prove new rabbit insemination extenders containing aminopeptidase inhibitors (AMIs) with or without chitosan (CS)-dextran sulfate (DS) nanoparticles entrapping the GnRH analogue. In addition, different hormone concentrations were tested in these extenders, evaluating their in vivo effect on rabbit reproductive performance after artificial insemination. A total of 911 females were inseminated with semen diluted with the four experimental extenders (C4 group: 4 μg buserelin/doe in control medium (Tris-citric acid-glucose supplemented with bestatin 10 μM and EDTA 20 mM), C5 group: 5 μg of buserelin/doe in control medium, Q4 group: 4 μg of buserelin/doe into CS-DS nanoparticles in control medium, Q5 group: 5 μg of busereline/doe into CS-DS nanoparticles in control medium)...
May 16, 2018: Theriogenology
https://www.readbyqxmd.com/read/29774548/release-of-tgf-%C3%AE-1-into-root-canals-with-various-final-irrigants-in-regenerative-endodontics-an-in-vitro-analysis
#15
Y Chae, M Yang, J R Kim
AIM: To investigate the release of growth factors into the root canal space after various final irrigants during regenerative endodontic procedures. The residual cytotoxic effect of final irrigants on stem cells from the apical papilla (SCAP) was also examined. METHODOLOGY: To measure the release of TGF-β1, root segments (8mm long) were irrigated with 1.5% NaOCl followed by 20 mL of final irrigants; Saline, 17% EDTA, 10% citric acid, 10% or 37% phosphoric acid...
May 17, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29773982/training-rats-using-water-rewards-without-water-restriction
#16
Pamela Reinagel
High-throughput behavioral training of rodents has been a transformative development for systems neuroscience. Water or food restriction is typically required to motivate task engagement. We hypothesized a gap between physiological water need and hedonic water satiety that could be leveraged to train rats for water rewards without water restriction. We show that when Citric Acid (CA) is added to water, female rats drink less, yet consume enough to maintain long term health. With 24 h/day access to a visual task with water rewards, rats with ad lib CA water performed 84% ± 18% as many trials as in the same task under water restriction...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29773393/comparative-study-of-physicochemical-properties-and-bioactivity-of-hericium-erinaceus-polysaccharides-at-different-solvent-extractions
#17
Jing-Kun Yan, Zhi-Chao Ding, Xianli Gao, Yao-Yao Wang, Yan Yang, Di Wu, He-Nan Zhang
In this study, hot water, 0.9% NaCl, citric acid, and 1.25 M NaOH/0.05% NaBH4 were separately used for the extraction of water-soluble H. erinaceus polysaccharides (HEPs; HEP-W, HEP-S, HEP-C, and HEP-A) from the fruit body of Hericium erinaceus. The physicochemical properties and biological activities were then investigated and compared. Results showed that the extraction solvents exhibited significant effects on the extraction yields, molecular weights, monosaccharide compositions, preliminary structural characteristics, microstructures of HEPs and on their contents, such as neutral sugar, uronic acid, protein, and β-(1 → 3)-glucan...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29770687/spatial-associations-and-chemical-composition-of-organic-carbon-sequestered-in-fe-ca-and-organic-carbon-ternary-systems
#18
Tyler Sowers, Dinesh Adhikari, Jian Wang, Yu Yang, Donald L Sparks
Organo-mineral associations of organic carbon (OC) with iron (Fe) oxides play a major role in environmental OC sequestration, a process crucial to mitigating climate change. Calcium has been found to have high co-association with OC in soils containing high Fe content, increase OC sorption extent to poorly-crystalline Fe oxides, and has long been suspected to form bridging complexes with Fe and OC. Due to the growing realization that Ca may be an important component of C cycling, we launched a scanning transmission X-ray microscopy (STXM) investigation, paired with near-edge X-ray absorption fine structure (NEXAFS) spectroscopy, in order to spatially resolve Fe, Ca, and OC relationships and probe the effect of Ca on sorbed OC speciation...
May 17, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29770130/bacteriophage-infectivity-against-pseudomonas-aeruginosa-in-saline-conditions
#19
Giantommaso Scarascia, Scott A Yap, Anna H Kaksonen, Pei-Ying Hong
Pseudomonas aeruginosa is a ubiquitous member of marine biofilm, and reduces thiosulfate to produce toxic hydrogen sulfide gas. In this study, lytic bacteriophages were isolated and applied to inhibit the growth of P. aeruginosa in planktonic mode at different temperature, pH, and salinity. Bacteriophages showed optimal infectivity at a multiplicity of infection of 10 in saline conditions, and demonstrated lytic abilities over all tested temperature (25, 30, 37, and 45°C) and pH 6-9. Planktonic P. aeruginosa exhibited significantly longer lag phase and lower specific growth rates upon exposure to bacteriophages...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29767468/central-adenosine-a-1-receptors-inhibit-cough-via-suppression-of-excitatory-glutamatergic-and-tachykininergic-neurotransmission
#20
Ahmed Z El-Hashim, Seena Mathews, Fajer Al-Shamlan
BACKGROUND AND PURPOSE: The A1 adenosine receptor is reported to mediate several excitatory effects in the airways and has inhibitory effects in the central nervous system. In this study, we investigated the role of peripheral and central A1 adenosine receptors in regulating cough and airway obstruction. EXPERIMENTAL APPROACH: Drugs were administered to guinea pigs via the inhaled or intracerebroventricular (i.c.v.) routes. Cough was induced by exposing guinea pigs to aerosolised 0...
May 16, 2018: British Journal of Pharmacology
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