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https://www.readbyqxmd.com/read/28428623/paper-strip-embedded-graphene-quantum-dots-a-screening-device-with-a-smartphone-readout
#1
Ruslan Álvarez-Diduk, Jahir Orozco, Arben Merkoçi
Simple, inexpensive and rapid sensing systems are very demanded for a myriad of uses. Intrinsic properties of emerging paper-based analytical devices have demonstrated considerable potential to fulfill such demand. This work reports an easy-to-use, low cost, and disposable paper-based sensing device for rapid chemical screening with a smartphone readout. The device comprises luminescent graphene quantum dots (GQDs) sensing probes embedded into a nitrocellulose matrix where the resonance energy transfer phenomenon seems to be the sensing mechanism...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28426572/nonhealing-ulcers-in-patients-with-tophaceous-gout-a-systematic-review
#2
Gretl Lam, Frank L Ross, Ernest S Chiu
GENERAL PURPOSE: To provide information from a review of the literature about chronic ulcers associated with tophaceous gout. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant should be better able to:1. Identify the pathophysiology of tophaceous gout, its presentation, phases, and common comorbidities...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28424313/reduction-in-activity-by-noxious-chemical-stimulation-is-ameliorated-by-immersion-in-analgesic-drugs-in-zebrafish
#3
Javier Lopez-Luna, Qussay Al-Jubouri, Waleed Al-Nuaimy, Lynne U Sneddon
Research has recently demonstrated that larval zebrafish show similar molecular responses to nociception to those of adults. Our study explored whether unprotected larval zebrafish exhibited altered behaviour after exposure to noxious chemicals and screened a range of analgesic drugs to determine their efficacy to reduce these responses. This approach aimed to validate larval zebrafish as a reliable replacement for adults as well as providing a high-throughput means of analysing behavioural responses. Zebrafish at 5 days post-fertilization were exposed to known noxious stimuli: acetic acid (0...
April 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28423712/model-based-unsupervised-learning-informs-metformin-induced-cell-migration-inhibition-through-an-ampk-independent-mechanism-in-breast-cancer
#4
Arjun P Athreya, Krishna R Kalari, Junmei Cairns, Alan J Gaglio, Quin F Wills, Nifang Niu, Richard Weinshilboum, Ravishankar K Iyer, Liewei Wang
We demonstrate that model-based unsupervised learning can uniquely discriminate single-cell subpopulations by their gene expression distributions, which in turn allow us to identify specific genes for focused functional studies. This method was applied to MDA-MB-231 breast cancer cells treated with the antidiabetic drug metformin, which is being repurposed for treatment of triple-negative breast cancer. Unsupervised learning identified a cluster of metformin-treated cells characterized by a significant suppression of 230 genes (p-value < 2E-16)...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421045/cranberry-juice-and-combinations-of-its-organic-acids-are-effective-against-experimental-urinary-tract-infection
#5
Heidi D Jensen, Carsten Struve, Søren B Christensen, Karen A Krogfelt
The antibacterial effect of cranberry juice and the organic acids therein on infection by uropathogenic Escherichia coli was studied in an experimental mouse model of urinary tract infection (UTI). Reduced bacterial counts were found in the bladder (P < 0.01) of mice drinking fresh cranberry juice. Commercially available cranberry juice cocktail also significantly reduced (P < 0.01) bacterial populations in the bladder, as did the hydrophilic fraction of cranberry juice (P < 0.05). Quinic, malic, shikimic, and citric acid, the preponderant organic acids in cranberry juice, were tested in combination and individually...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28420467/-study-of-plasma-amino-acid-related-metabolites-of-septic-rats-using-gas-chromatography-mass-spectrometry
#6
Jin Su, Yimin Zhu, Yu Jiang, Lianhong Zou, Xiaoliang Liu, Yixiao Xu
OBJECTIVE: To reveal the pathophysiological changes of sepsis, the plasma metabonomics of septic rats was determined and differential metabolites were determined by gas chromatography-mass spectrometry (GC-MS). METHODS: Male Spraguee-Dawley (SD) rats about 8 weeks were randomly divided into sham group (n = 18) and sepsis group (n = 24). Cecal ligation and puncture (CLP) was used to build sepsis model, while cecum was kept intact only in the sham group. 6 hours after the operation, rats were anesthetized, and blood was harvested through heart thoracotomy...
April 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28416775/volatile-organic-compounds-in-gastrointestinal-stromal-tumour-tissue-originating-from-patient-derived-xenografts
#7
Renata Wawrzyniak, Agnieszka Woźniak, Yemarshet Gebreyohannes, Bartosz Dykcik, Patrick Schöffski, Michal Markuszewski
Gastrointestinal stromal tumours (GIST) are the most common mesenchymal neoplasms of the gastrointestinal tract, localized mainly in the stomach or small intestine. The metabolomic signature of GIST signature associated with various mutations in KIT gene remains undiscovered and unexplored. The main aim of this pilot study was to determine and compare metabolomic profiles in GIST xenograft models with different genetic background. Metabolomic profiling using gas chromatography coupled with mass spectrometry followed by both univariate and multivariate statistical analyses was applied to select metabolites which differentiate the GIST models studied...
April 18, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28416376/seminal-plasma-removal-by-density-gradient-centrifugation-is-superior-for-goat-sperm-preservation-compared-with-classical-sperm-washing
#8
J Santiago-Moreno, M C Esteso, C Castaño, A Toledano-Díaz, J A Delgadillo, A López-Sebastián
Seminal plasma removal is routine in goat sperm cryopreservation protocols. The classical washing procedure designed to accomplish this usually leaves the pellet resulting from use of this procedure contaminated with dead sperm, debris, and cells other than sperm. This contamination negatively affects viability of sperm after cryopreservation. The present research was conducted to compare the effect on chilled and frozen-thawed goat sperm of the classical washing method to that of a selective washing method involving density gradient centrifugation (DGC)...
April 9, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28415449/complementary-approaches-for-the-evaluation-of-biocompatibility-of-90-y-labeled-superparamagnetic-citric-acid-fe-er-3o4-coated-nanoparticles
#9
Bratislav Antic, Marko Boskovic, Jasmina Nikodinovic-Runic, Yue Ming, Hongguo Zhang, Emil S Bozin, Drina Janković, Vojislav Spasojevic, Sanja Vranjes-Djuric
Magnetic nanoparticles (MNPs) are of immense interest for diagnostic and therapeutic applications in medicine. Design and development of new iron oxide-based MNPs for such applications is of rather limited breadth without reliable and sensitive methods to determine their levels in body tissues. Commonly used methods, such as ICP, are quite problematic, due to the inability to decipher the origin of the detected iron, i.e. whether it originates from the MNPs or endogenous from tissues and bodily fluids. One of the approaches to overcome this problem and to increase reliability of tracing MNPs is to partially substitute iron ions in the MNPs with Er...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28412486/removal-of-toxic-metals-from-vanadium-contaminated-soils-using-a-washing-method-reagent-selection-and-parameter-optimization
#10
Jianguo Jiang, Meng Yang, Yuchen Gao, Jiaming Wang, Dean Li, Tianran Li
Vanadium (V) contamination in soils is an increasing worldwide concern facing human health and environmental conservation. The fractionation of a metal influences its mobility and biological toxicity. We analyzed the fractionations of V and several other metals using the BCR three-step sequential extraction procedure. Among methods for removing metal contamination, soil washing is an effective permanent treatment. We conducted experiments to select the proper reagents and to optimize extraction conditions. Citric acid, tartaric acid, oxalic acid, and Na2EDTA all exhibited high removal rates of the extractable state of V...
March 31, 2017: Chemosphere
https://www.readbyqxmd.com/read/28412482/dapagliflozin-citric-acid-cocrystal-showing-better-solid-state-properties-than-dapagliflozin
#11
Jun-Hui Deng, Tong-Bu Lu, Changquan Calvin Sun, Jia-Mei Chen
Dapagliflozin (DAP) is a potent and selective sodium-glucose contransporter-2 inhibitor, for treating type 2 diabetes. DAP propanediol monohydrate (DAP-PDO-H2O, 1:1:1) is the solid form used in the current tablet product to address the severe hygroscopicity problem of DAP free form. DAP-PDO-H2O, however, suffers the problem of instability when exposed to high temperature, which renders it amorphous. In this work, we report on the preparation and evaluation of a new 1:1 cocrystal between DAP and citric acid (DAP-CA)...
April 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28411229/a-comprehensive-analysis-of-myocardial-substrate-preference-emphasizes-the-need-for-a-synchronized-fluxomic-metabolomic-research-design
#12
Mukundan Ragavan, Alexander Kirpich, Xiaorong Fu, Shawn C Burgess, Lauren M McIntyre, Matthew E Merritt
The heart oxidizes fatty acids, carbohydrates and ketone bodies inside the citric acid cycle (CAC) to generate the reducing equivalents needed for ATP production. Competition between these substrates makes it difficult to estimate the extent of pyruvate oxidation. Previously, hyperpolarized pyruvate detected propionate mediated activation of carbohydrate oxidation, even in the presence of acetate. In this report, the optimal concentration of propionate for activation of glucose oxidation is measured in mouse hearts perfused in Langendorff mode...
April 14, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28408944/pc2-ovotransferrin-characterization-and-alternative-immunotherapeutic-activity
#13
Constantin Chiurciu, Viorica Chiurciu, Mariana Oporanu, Ionel Victor Pătrașcu, Iuliana Mihai, Mădălina Tablică, Romeo Teodor Cristina
Characterization and evaluation of immunotherapeutic potential of ovotransferrin PC2 (OTf PC2) were performed in this study. The ovoprotein was obtained from egg white from hens immunized with bacterial antigens, pathogenic for humans. For the negative control samples, OTf was extracted from eggs collected from Specific Pathogen-Free (SPF) hens and purified by affinity chromatography on Protein G-agarose column with two eluting peaks: I, representing ovalbumin, and II, ovotransferrin. The final apo-OTf form was reached by successive precipitation with ammonium sulfate and citric acid and the holo-OTf form by saturating the apo-form with FeCl3...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28408822/negatively-charged-silver-nanoparticles-with-potent-antibacterial-activity-and-reduced-toxicity-for-pharmaceutical-preparations
#14
Lucia Salvioni, Elisabetta Galbiati, Veronica Collico, Giulia Alessio, Svetlana Avvakumova, Fabio Corsi, Paolo Tortora, Davide Prosperi, Miriam Colombo
BACKGROUND: The discovery of new solutions with antibacterial activity as efficient and safe alternatives to common preservatives (such as parabens) and to combat emerging infections and drug-resistant bacterial pathogens is highly expected in cosmetics and pharmaceutics. Colloidal silver nanoparticles (NPs) are attracting interest as novel effective antimicrobial agents for the prevention of several infectious diseases. METHODS: Water-soluble, negatively charged silver nanoparticles (AgNPs) were synthesized by reduction with citric and tannic acid and characterized by transmission electron microscopy, dynamic light scattering, zeta potential, differential centrifuge sedimentation, and ultraviolet-visible spectroscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408756/apple-pomace-improves-the-quality-of-pig-manure-aerobic-compost-by-reducing-emissions-of-nh3-and-n2o
#15
Hui Mao, Teng Zhang, Ronghua Li, Bingnian Zhai, Zhaohui Wang, Quan Wang, Zengqiang Zhang
In this study, the effects of apple pomace (AP) addition (0%, 5%, 10%, and 20% on a dry weight basis, named as control, AP1, AP2, and AP3) and citric acid (CA) addition on nitrogen conservation were investigated during aerobic composting of pig manure. Gaseous emissions of NH3 and N2O were inhibited by AP and CA addition, with AP's effect greater. The inhibition improved with increasing AP addition. The AP3 treatment was the most effective on NH3 adsorption and transformation to [Formula: see text]-N, improved with subsequent transformation to [Formula: see text]-N, and inhibition of N2O and [Formula: see text] production...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28406141/role-of-slow-release-nanocomposite-fertilizers-on-nitrogen-and-phosphate-availability-in-soil
#16
Amanda S Giroto, Gelton G F Guimarães, Milene Foschini, Caue Ribeiro
Developing efficient crop fertilization practices has become more and more important due to the ever-increasing global demand for food production. One approach to improving the efficiency of phosphate and urea fertilization is to improve their interaction through nanocomposites that are able to control the release of urea and P in the soil. Nanocomposites were produced from urea (Ur) or extruded thermoplastic starch/urea (TPSUr) blends as a matrix in which hydroxyapatite particles (Hap) were dispersed at ratios 50% and 20% Hap...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28405461/feed-additives-decrease-survival-of-delta-coronavirus-in-nursery-pig-diets
#17
Katie M Cottingim, Harsha Verma, Pedro E Urriola, Fernando Sampedro, Gerald C Shurson, Sagar M Goyal
BACKGROUND: Feed contaminated with feces from infected pigs is believed to be a potential route of transmission of porcine delta coronavirus (PDCoV). The objective of this study was to determine if the addition of commercial feed additives (e.i., acids, salt and sugar) to swine feed can be an effective strategy to inactive PDCoV. RESULTS: Six commercial feed acids (UltraAcid P, Activate DA, KEMGEST, Acid Booster, Luprosil, and Amasil), salt, and sugar were evaluated...
2017: Porcine Health Management
https://www.readbyqxmd.com/read/28403831/the-role-of-tre6p-and-snrk1-in-maize-early-kernel-development-and-events-leading-to-stress-induced-kernel-abortion
#18
Samuel W Bledsoe, Clémence Henry, Cara A Griffiths, Matthew J Paul, Regina Feil, John E Lunn, Mark Stitt, L Mark Lagrimini
BACKGROUND: Drought stress during flowering is a major contributor to yield loss in maize. Genetic and biotechnological improvement in yield sustainability requires an understanding of the mechanisms underpinning yield loss. Sucrose starvation has been proposed as the cause for kernel abortion; however, potential targets for genetic improvement have not been identified. Field and greenhouse drought studies with maize are expensive and it can be difficult to reproduce results; therefore, an in vitro kernel culture method is presented as a proxy for drought stress occurring at the time of flowering in maize (3 days after pollination)...
April 12, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28401763/mineral-availability-as-a-key-regulator-of-soil-carbon-storage
#19
Guanghui Yu, Jian Xiao, Shuijin Hu, Matthew L Polizzotto, Fangjie Zhao, Steve P McGrath, Huan Li, Wei Ran, Qirong Shen
Mineral binding is a major mechanism for soil carbon (C) stabilization, and mineral availability for C binding critically affects C storage. Yet, the mechanisms regulating mineral availability are poorly understood. Here, we showed that organic amendments in three long-term (23, 154, and 170 yrs, respectively) field experiments significantly increased mineral availability, particularly of short-range-ordered (SRO) phases. Two microcosm studies demonstrated that the presence of roots significantly increased mineral availability and promoted the formation of SRO phases...
April 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28400011/use-of-enhanced-nisin-derivatives-in-combination-with-food-grade-oils-or-citric-acid-to-control-cronobacter-sakazakii-and-escherichia-coli-o157-h7
#20
Alicia Campion, Ruth Morrissey, Des Field, Paul D Cotter, Colin Hill, R Paul Ross
Cronobacter sakazakii and Escherichia coli O157:H7 are well known food-borne pathogens that can cause severe disease. The identification of new alternatives to heating to control these pathogens in foods, while reducing the impact on organoleptic properties and nutritional value, is highly desirable. In this study, nisin and its bioengineered variants, nisin V and nisin S29A, are used alone, or in combination with plant essential oils (thymol, carvacrol and trans-cinnamaldehyde) or citric acid, with a view to controlling C...
August 2017: Food Microbiology
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