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https://www.readbyqxmd.com/read/28346440/endocytic-proteins-are-partitioned-at-the-edge-of-the-clathrin-lattice-in-mammalian-cells
#1
Kem A Sochacki, Andrea M Dickey, Marie-Paule Strub, Justin W Taraska
Dozens of proteins capture, polymerize and reshape the clathrin lattice during clathrin-mediated endocytosis (CME). How or if this ensemble of proteins is organized in relation to the clathrin coat is unknown. Here, we map key molecules involved in CME at the nanoscale using correlative super-resolution light and transmission electron microscopy. We localize 19 different endocytic proteins (amphiphysin1, AP2, β2-arrestin, CALM, clathrin, DAB2, dynamin2, EPS15, epsin1, epsin2, FCHO2, HIP1R, intersectin, NECAP, SNX9, stonin2, syndapin2, transferrin receptor, VAMP2) on thousands of individual clathrin structures, generating a comprehensive molecular architecture of endocytosis with nanoscale precision...
March 27, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28342096/-emergency-treatment-of-tachycardias
#2
N Deubner, H Greiss, T Neumann
The treatment of symptomatic tachycardia is a key challenge in intensive care medicine and emergency care. Making a quick and authoritative diagnosis on an ECG and applying adequate emergency treatment requires a structured approach to analyzing and treating arrhythmias. This CME article offers a practical categorization of the multitude of tachycardias, with medical and electrical treatment options and ECG examples. Appropriate first- and second-line treatment options are presented for most common tachyarrhythmias...
March 24, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28341132/stochastic-modeling-and-numerical-simulation-of-gene-regulatory-networks-with-protein-bursting
#3
Manuel Pájaro, Antonio A Alonso, Irene Otero-Muras, C Vázquez
Gene expression is inherently stochastic. Advanced single-cell microscopy techniques together with mathematical models for single gene expression led to important insights in elucidating the sources of intrinsic noise in prokaryotic and eukaryotic cells. In addition to the finite size effects due to low copy numbers, translational bursting is a dominant source of stochasticity in cell scenarios involving few short lived mRNA transcripts with high translational efficiency (as is typically the case for prokaryotes), causing protein synthesis to occur in random bursts...
March 21, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28328965/peripheral-blood-metabolic-and-inflammatory-factors-as-biomarkers-to-ocular-findings-in-diabetic-macular-edema
#4
Marc Figueras-Roca, Blanca Molins, Anna Sala-Puigdollers, Jessica Matas, Irene Vinagre, José Ríos, Alfredo Adán
AIMS: To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients. MATERIAL AND METHODS: Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DME (n = 18) according to optical coherence tomography (OCT). Ultra-widefield fluorescein angiography (UWFA) was performed in DME patients...
2017: PloS One
https://www.readbyqxmd.com/read/28327657/dynasore-impairs-vegfr2-signalling-in-an-endocytosis-independent-manner
#5
Dimitris Basagiannis, Sofia Zografou, Katerina Galanopoulou, Savvas Christoforidis
VEGFR2 is a critical angiogenic receptor playing a key role in vascular homeostasis. Upon activation by VEGF, VEGFR2 becomes endocytosed. Internalisation of VEGFR2 is facilitated, in part, through clathrin mediated endocytosis (CME), the role of which in VEGFR2 function is debated. Here, we confirm the contribution of CME in VEGFR2 uptake. However, curiously, we find that different approaches of inhibition of CME exert contradictory effects on VEGF signalling; knockdown of clathrin, or of dynamin, or overexpression of dynamin K44A, do not affect VEGF-induced phosphorylation of ERK1/2, while dynasore causes strong inhibition...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327100/impact-of-a-continuing-medical-education-meeting-on-the-use-and-timing-of-urgent-cancer-referrals-among-general-practitioners-a-before-after-study
#6
Berit Skjødeberg Toftegaard, Flemming Bro, Alina Zalounina Falborg, Peter Vedsted
BACKGROUND: Detection of cancer in general practice is challenging because symptoms are diverse. Even so-called alarm symptoms have low positive predictive values of cancer. Nevertheless, appropriate referral is crucial. As 85% of cancer patients initiate their cancer diagnostic pathway in general practice, a Continuing Medical Education meeting (CME-M) in early cancer diagnosis was launched in Denmark in 2012. We aimed to investigate the effect of the CME-M on the primary care interval, patient contacts with general practice and use of urgent cancer referrals...
March 21, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28323789/featured-articles-for-cme-credit-april-2017
#7
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28314867/-surgical-training-in-orthopedics-and-trauma-surgery-to-prepare-for-the-specialist-examination-or-as-a-cme-refresher
#8
EDITORIAL
M Blauth, K Dresing, F Unglaub
No abstract text is available yet for this article.
March 17, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28314570/soard-category-1-cme-credit-featured-articles-volume-13-march-2017
#9
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28314569/soard-category-1-cme-credit-featured-articles-volume-13-february-2017
#10
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28301975/associations-between-teaching-effectiveness-and-participant-self-reflection-in-continuing-medical-education
#11
John T Ratelle, Sara L Bonnes, Amy T Wang, Saswati Mahapatra, Cathy D Schleck, Jayawant N Mandrekar, Karen F Mauck, Thomas J Beckman, Christopher M Wittich
Effective medical educators can engage learners through self-reflection. However, little is known about the relationships between teaching effectiveness and self-reflection in continuing medical education (CME). We aimed to determine associations between presenter teaching effectiveness and participant self-reflection in conference-based CME. This cross-sectional study evaluated presenters and participants at a national CME course. Participants provided CME teaching effectiveness (CMETE) ratings and self-reflection scores for each presentation...
March 16, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28294382/the-role-of-morbidity-and-mortality-rounds-in-medical-education-a-scoping-review
#12
REVIEW
Paul Benassi, Lindsey MacGillivray, Ivan Silver, Sanjeev Sockalingam
CONTEXT: There is increasing focus on how health care professionals can be trained effectively in quality improvement and patient safety principles. The morbidity and mortality round (MMR) has often been used as a tool with which to examine and teach care quality, yet little is known of its implementation and educational outcomes. OBJECTIVES: The objectives of this scoping review are to examine and summarise the literature on how the MMR is designed and delivered, and to identify how it is evaluated for effectiveness in addressing medical education outcomes...
March 14, 2017: Medical Education
https://www.readbyqxmd.com/read/28294295/breast-cancer-major-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#13
Armando E Giuliano, James L Connolly, Stephen B Edge, Elizabeth A Mittendorf, Hope S Rugo, Lawrence J Solin, Donald L Weaver, David J Winchester, Gabriel N Hortobagyi
Answer questions and earn CME/CNE The revision of the eighth edition of the primary tumor, lymph node, and metastasis (TNM) classification of the American Joint Commission of Cancer (AJCC) for breast cancer was determined by a multidisciplinary team of breast cancer experts. The panel recognized the need to incorporate biologic factors, such as tumor grade, proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression prognostic panels into the staging system...
March 14, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28287688/light-induced-translocation-of-a-conjugated-polyelectrolyte-in-cells-from-fluorescent-probe-to-anticancer-agent
#14
Pan Wu, Naihan Xu, Chunyan Tan, Lei Liu, Ying Tan, Zhifang Chen, Yuyang Jiang
Dual-functional probes, which not only enable visualization of diseased cells but also induce therapeutic cellular responses, are essential to biological studies. In the current work, a conjugated polyelectrolyte, PPET3-N2, was designed and synthesized as a dual-functional probe. The polyphenylene ethynylene terthiophene polymer backbone contributes to the polymer's light-harvesting property to ensure the strong fluorescence as well as photosensitization, whereas quantanary ammonium side chains interact with target organelle for localization...
March 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28285536/comparison-of-short-term-outcomes-between-laparoscopic-assisted-and-open-complete-mesocolic-excision-cme-for-the-treatment-of-transverse-colon-cancer
#15
COMPARATIVE STUDY
Yong Wang, Chuan Zhang, Yi-Fei Feng, Zan Fu, Yue-Ming Sun
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer worldwide. Although laparoscopic-assisted complete mesocolic excision (LCME) is a superior treatment, there are few studies available on it owe to the low incidence and technical difficulty of LCME in transverse colon cancer. METHODS: The clinical data of 78 patients with transverse colon cancer who were treated by LCME and open complete mesocolic excision (OCME) were retrospectively analyzed. A total of 39 cases had been treated by LCME, compared with 39 cases treated by OCME...
February 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28279950/insuonline-an-electronic-game-for-medical-education-on-insulin-therapy-a-randomized-controlled-trial-with-primary-care-physicians
#16
Leandro Arthur Diehl, Rodrigo Martins Souza, Pedro Alejandro Gordan, Roberto Zonato Esteves, Izabel Cristina Meister Coelho
BACKGROUND: Most patients with diabetes mellitus (DM) are followed by primary care physicians, who often lack knowledge or confidence to prescribe insulin properly. This contributes to clinical inertia and poor glycemic control. Effectiveness of traditional continuing medical education (CME) to solve that is limited, so new approaches are required. Electronic games are a good option, as they can be very effective and easily disseminated. OBJECTIVE: The objective of our study was to assess applicability, user acceptance, and educational effectiveness of InsuOnline, an electronic serious game for medical education on insulin therapy for DM, compared with a traditional CME activity...
March 9, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28248696/the-leadership-case-for-investing-in-continuing-professional-development
#17
Graham T McMahon
Continuing medical education (CME) has the power and capacity to address many challenges in the health care environment, from clinician well-being to national imperatives for better health, better care, and lower cost. Health care leaders who recognize the strategic value of education and engage their people in education can expect a meaningful return on their investment-not only in terms of the quality and safety of their clinicians' work but also in the spirit and cohesiveness of the clinicians who work at their institution...
February 28, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28248690/responsiveness-of-myofascial-trigger-points-to-single-and-multiple-trigger-point-release-massages-a-randomized-placebo-controlled-trial
#18
Albert F Moraska, Sarah J Schmiege, John D Mann, Nathan Butryn, Jason P Krutsch
OBJECTIVE: This study aimed to assess the effects of single and multiple massage treatments on pressure-pain threshold (PPT) at myofascial trigger points (MTrPs) in people with myofascial pain syndrome expressed as tension-type headache. DESIGN: Individuals (n = 62) with episodic or chronic tension-type headache were randomized to receive 12 twice-weekly 45-min massage or sham ultrasound sessions or wait-list control. Massage focused on trigger point release (ischemic compression) of MTrPs in the bilateral upper trapezius and suboccipital muscles...
February 28, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28243022/immediate-postoperative-intraocular-pressure-adjustment-reduces-risk-of-cystoid-macular-edema-after-uncomplicated-micro-incision-coaxial-phacoemulsification-cataract-surgery
#19
RANDOMIZED CONTROLLED TRIAL
John S Jarstad, Allison R Jarstad, Gary W Chung, Robert A Tester, Linda E Day
PURPOSE: To determine the accuracy of visual estimation of immediate postoperative intraocular pressure (IOP) following microincision cataract surgery (MICS) and the effect of immediate postoperative IOP adjustment on prevention of cystoid macular edema (CME). SETTING: Ambulatory surgical center. METHODS: Prospective, randomized analysis of 170 eyes in 135 patients with MICS, performed in a Medicare approved outpatient ambulatory surgery center...
February 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28242543/multiple-pharmacological-targets-cytotoxicity-and-phytochemical-profile-of-aphloia-theiformis-vahl-benn
#20
Marie Carene Nancy Picot, Onur Bender, Arzu Atalay, Gokhan Zengin, Loïc Loffredo, Francis Hadji-Minaglou, Mohamad Fawzi Mahomoodally
Aphloia theiformis (Vahl.) Benn. (AT) is traditionally used in Sub-Saharan African countries including Mauritius as a biomedicine for the management of several diseases. However, there is a dearth of experimental studies to validate these claims. We endeavoured to evaluate the inhibitory effects of crude aqueous extract as traditionally used together with the crude methanol extracts of AT leaves on urease, angiotensin (I) converting enzyme (ACE), acetylcholinesterase (AChE), cholesterol esterase (CEase), glycogen phosphorylase a (GPa), and glycation in vitro...
February 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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