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https://www.readbyqxmd.com/read/28419451/do-state-continuing-medical-education-requirements-for-physicians-improve-clinical-knowledge
#1
Jonathan L Vandergrift, Bradley M Gray, Weifeng Weng
OBJECTIVE: To evaluate the effect of state continuing medical education (CME) requirements on physician clinical knowledge. DATA SOURCES: Secondary data for 19,563 general internists who took the Internal Medicine Maintenance of Certification (MOC) examination between 2006 and 2013. STUDY DESIGN: We took advantage of a natural experiment resulting from variations in CME requirements across states over time and applied a difference-in-differences methodology to measure associations between changes in CME requirements and physician clinical knowledge...
April 16, 2017: Health Services Research
https://www.readbyqxmd.com/read/28418777/er-la-opioid-rems-and-accredited-education-survey-results-provide-insight-into-clinical-roles-educational-needs-and-learner-preferences
#2
Cynthia Kear, Tom McKeithen, Sheila Robertson
BACKGROUND: The Collaborative for REMS Education (CO*RE) includes 13 organizations who provide REMS Program Companies (RPC) grant-supported accredited education on extended-release and long-acting (ER/LA) opioid therapy. This report summarizes results of a survey designed to investigate the impact of participant criteria and to better understand the roles and preferences of CME/CE participants. METHODS: In April 2015, we made an online survey available to an estimated 10,000 clinicians who had completed a CO*RE CME/CE activity since 2013...
April 18, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28416209/-is-the-formal-quality-of-multiple-choice-questions-used-for-continuing-medical-education-influenced-by-guidelines-for-authors-provided-by-the-publishing-houses
#3
Sabine Drossard, Daniel Bauer, Martin Fischer, Lisa Kühne-Eversmann
INTRODUCTION: The widespread use of flawed multiple choice questions (MCQs) in continuing medical education (CME) has been demonstrated in different studies. In recent years, quality control measures have been established by some German publishing houses to ensure the quality of MCQs. OBJECTIVES: The purpose of the present study is to evaluate whether the quality of author's guidelines and the quality of MCQs correlate and whether the quality of MCQs in CME has improved following the implementation of quality control measures...
April 14, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28414717/a-ca2-channel-differentially-regulates-clathrin-mediated-and-activity-dependent-bulk-endocytosis
#4
Chi-Kuang Yao, Yu-Tzu Liu, I-Chi Lee, You-Tung Wang, Ping-Yen Wu
Clathrin-mediated endocytosis (CME) and activity-dependent bulk endocytosis (ADBE) are two predominant forms of synaptic vesicle (SV) endocytosis, elicited by moderate and strong stimuli, respectively. They are tightly coupled with exocytosis for sustained neurotransmission. However, the underlying mechanisms are ill defined. We previously reported that the Flower (Fwe) Ca2+ channel present in SVs is incorporated into the periactive zone upon SV fusion, where it triggers CME, thus coupling exocytosis to CME...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28414561/interferon-alpha-for-the-treatment-of-cystoid-macular-edema-associated-with-presumed-ocular-tuberculosis
#5
Merih Oray, Sumru Onal, Gunay Uludag, Aylin Koc Akbay, Ilknur Tugal-Tutkun
PURPOSE: To report the efficacy and safety of interferon (IFN) α-2a in patients with cystoid macular edema (CME) associated with presumed ocular tuberculosis (TB). METHODS: We reviewed the clinical records of 5 patients with presumed ocular TB who had been treated with IFN α-2a for recurrent CME during or after completion of anti-tubercular therapy. IFN α-2a was administered at an initial dose of 3 million IU per day and then tapered after the initial response...
April 17, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28414434/ammonia-activation-h2-evolution-and-nitride-formation-from-a-molybdenum-complex-with-a-chemically-and-redox-non-innocent-ligand
#6
Grant W Margulieux, Mate J Bezdek, Zoë R Turner, Paul J Chirik
Treatment of the bis(imino)pyridine molybdenum η6-benzene complex (iPrPDI)Mo(η6-C6H6) (iPrPDI, 2,6-(2,6-iPr2C6H3N=CMe)2C5H3N) with NH3 resulted in coordination in-duced haptotropic rearrangement of the arene to form (iPrPDI)Mo(NH3)2(η2-C6H6). Analogous η2-ethylene and η2-cyclohexene complexes were also synthesized and the latter crystallo-graphically characterized. All three compounds undergo loss of the η2-coordinated ligand followed by N-H bond activation, bis(imino)pyridine modification and H2 loss...
April 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28413117/structure-specific-movement-patterns-in-patients-with-chronic-low-back-dysfunction-using-lumbar-combined-movement-examination
#7
Aubrey P Monie, Roger I Price, Christopher R P Lind, Kevin P Singer
OBJECTIVE: A test-retest cohort study was conducted to assess the use of a novel computer-aided, combined movement examination (CME) to measure change in low back movement after pain management intervention in 17 cases of lumbar spondylosis. Additionally we desired to use a CME normal reference range (NRR) to compare and contrast movement patterns identified from 3 specific structural pathologic conditions: intervertebral disc, facet joint, and nerve root compression. METHODS: Computer-aided CME was used before and after intervention, in a cohort study design, to record lumbar range of movement along with pain, disability, and health self-report questionnaires in 17 participants who received image-guided facet, epidural, and/or rhizotomy intervention...
April 13, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28403499/psychische-belastungsfaktoren-in-der-arbeitswelt-modelle-und-pr%C3%A3-vention
#8
Florian Junne, Monika Rieger, Martina Michaelis, Christoph Nikendei, Harald Gündel, Stephan Zipfel, Eva Rothermund
Psycho-mental stressors and increased perceived stress in workplace settings may determine the onset and course of stress-related mental and psychosomatic disorders. For the description of psycho-mental stressors three distinct models have widely been used in the analyses of the matter: the Demand-Control-Model by Karasek and Theorell, the Effort-Reward-Imbalance Model by Siegrist, and the Model of Organisational Justice.The interactional or social dimension in work-place settings can be seen as a cross-sectional dimension to the above mentioned models...
April 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28400686/convergence-of-minds-for-better-patient-outcome-in-intensive-care-unit-infections
#9
Chand Wattal, Yash Javeri, Neeraj Goel, Debashish Dhar, Sonal Saxena, Sarman Singh, Jaswinder Kaur Oberoi, B K Rao, Purva Mathur, Vikas Manchanda, Vivek Nangia, Arti Kapil, Ashok Rattan, Supradip Ghosh, Omender Singh, Vinod Singh, Iqbal Kaur, Sanghamitra Datta, Sharmila Sen Gupta
BACKGROUND: There is emergence of resistance to the last-line antibiotics such as carbapenems in Intensive Care Units (ICUs), leaving little effective therapeutic options. Since there are no more newer antibiotics in the armamentarium in the near future, it has become imperative that we harness the interdisciplinary knowledge for the best clinical outcome of the patient. AIMS: The aim of the conference was to utilize the synergies between the clinical microbiologists and critical care specialists for better patient care and clinical outcome...
March 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28397505/-current-recommendations-for-the-prevention-and-treatment-of-venous-thromboembolism-in-cancer-patients
#10
J Halámková, M Penka
About 20% of patients suffer from venous thromboembolism (VTE) during oncology disease. Active cancer, along with cancer therapy, increases the risk of VTE, especially in the first 6 months after diagnosis. Most often VTE accompanies haematological malignancies and CNS tumours, and gastrointestinal, breast, lung, ovary and uterine cancer. The presence of distant metastases, together with the implantation of a central venous catheter, increases the risk even more. A cancer patient also has a 2-5× higher risk of recurrence of VTE during anticoagulant therapy than patients without a malignancy, as well as a 2-6× higher risk of serious bleeding...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28391090/fast-and-ultrafast-endocytosis
#11
REVIEW
Shigeki Watanabe, Emmanuel Boucrot
Clathrin-mediated endocytosis (CME) is the main endocytic pathway supporting housekeeping functions in cells. However, CME may be too slow to internalize proteins from the cell surface during certain physiological processes such as reaction to stress hormones ('fight-or-flight' reaction), chemotaxis or compensatory endocytosis following exocytosis of synaptic vesicles or hormone-containing vesicles. These processes take place on a millisecond to second timescale and thus require very rapid cellular reaction to prevent overstimulation or exhaustion of the response...
April 5, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28388263/reversal-of-cystoid-macular-edema-in-gyrate-atrophy-patients
#12
Dan Heller, Chen Weiner, Iris Nasie, Yair Anikster, Yuval Landau, Tal Koren, Russell Pokroy, Adi Abulafia, Eran Pras
PURPOSE: This study reports the presentation of two families with gyrate atrophy (GA). The aim of this study was to characterize the potential effect of therapeutic regimens on macular edema. METHODS: Two unrelated patients with GA were studied for the potential effect of low protein diet (≤ 0.8 g/kg/d), and oral administration of pyridoxine (500 mg/day), on serum ornithine levels, best corrected visual acuity (BCVA), slit-lamp, OCT, and auto-fluorescence findings...
April 7, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28383292/corticomotor-excitability-effects-of-peripheral-nerve-electrical-stimulation-to-the-paretic-arm-in-stroke
#13
Hao Liu, Stephanie S Y Au-Yeung
OBJECTIVE: This study aimed to examine the corticomotor excitability changes after peripheral nerve electrical stimulation (PNS) on the stroke-impaired arm. DESIGN: This randomized cross-over study included 32 subjects with chronic stroke. They received a 1-hr PNS or placebo PNS by random order to the ulnar and radial nerves of the paretic arm in separate sessions. The primary outcome was excitability of the corticospinal projections for the contralateral first dorsal interosseous hand muscle in terms of slope of the recruitment curve, peak motor-evoked potential amplitude, and duration of the cortical silent period, measured with transcranial magnetic stimulation on both cerebral hemispheres...
April 5, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28378252/intravitreal-dexamethasone-implant-for-recalcitrant-cystoid-macular-edema-secondary-to-retinitis-pigmentosa-a-pilot-study
#14
Aditya Sudhalkar, Laurent Kodjikian, Nishikant Borse
BACKGROUND: To determine the utility of the intravitreal dexamethasone implant as therapy for cystoid macular edema (CME) secondary to retinitis pigmentosa (RP) recalcitrant to carbonic anhydrase inhibitor therapy over 2 years as a pilot study. METHODS: This was a prospective case series. Patients who showed either an incomplete or no response to topical dorzolamide for at least 1 month and oral acetazolamide therapy for at least 15 days were recruited for the study with informed consent...
April 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28373156/an-analysis-of-2-3-million-participations-in-the-continuing-medical-education-program-of-a-general-medical-journal-suitability-user-characteristics-and-evaluation-by-readers
#15
Hildegard Christ, Jeremy Franklin, Reinhard Griebenow, Christopher Baethge
BACKGROUND: Physicians frequently use continuing medical education (CME) in journals. However, little is known of the evaluation of journal CME by readers and also user and participation characteristics. Deutsches Ärzteblatt, the journal of the German Medical Association, is distributed to every physician in Germany and regularly offers its readers CME articles. Therefore, it provides a unique opportunity to analyze a journal CME program directed at an entire population of physicians...
April 3, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28366377/treatment-of-cystoid-macular-edema-after-cataract-surgery
#16
REVIEW
Laura H P Wielders, Jan S A G Schouten, Merel R Aberle, Verena A Lambermont, Frank J H M van den Biggelaar, Bjorn Winkens, Rob W P Simons, Rudy M M A Nuijts
The purpose of this review was to determine the optimum pharmacologic treatment for cystoid macular edema (CME) after cataract surgery in nondiabetic and diabetic patients. The Cochrane Library, Medline, and Embase databases were searched, and all randomized controlled trials (RCTs) that compared at least 2 pharmacologic strategies for CME after cataract surgery were included. Studies were excluded if preoperative CME or other risk factors for developing CME postoperatively were present. Ten RCTs were included in the systematic review...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28366368/risk-factors-for-and-diagnosis-of-pseudophakic-cystoid-macular-edema-after-cataract-surgery-in-diabetic-patients
#17
Jin Yang, Lei Cai, Zhongcui Sun, Hongfei Ye, Qi Fan, Keke Zhang, Wenyi Lu, Yi Lu
PURPOSE: To evaluate the risk factors and potential diagnostic criteria for pseudophakic cystoid macular edema (CME) in diabetic patients after phacoemulsification. SETTING: Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China. DESIGN: Prospective nonrandomized study. METHODS: Diabetic patients were followed for up to 6 months after cataract surgery and examined to evaluate their foveal thickness, macular sensitivity, and corrected distance visual acuity...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28365633/cme-cerebrovascular-disease-108460-self-assessment-questionnaire
#18
John Bamford, Tahseen A Chowdhury
No abstract text is available yet for this article.
April 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28360213/forty-years-on-clathrin-coated-pits-continue-to-fascinate
#19
Hannes Maib, Elizabeth Smythe, Kathryn Ayscough
Clathrin-mediated endocytosis (CME) is a fundamental process in cell biology and has been extensively investigated over the past several decades. Every cell biologist learns about it at some point during his or her education, and the beauty of this process has led many of us to go deeper and make it the topic of our research. Great progress has been made toward elucidating the mechanisms of CME, and the field is becoming increasingly complex, with several hundred new publications every year. This makes it easy to get lost in the vast amount of literature and forget about the fundamentals of the field, which are based on the careful interpretation of simple observations made >40 years ago, as exemplified by a study performed by Anderson, Brown, and Goldstein in 1977...
April 1, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28359050/tak-242-protects-against-apoptosis-in-coronary-microembolization-induced-myocardial-injury-in-rats-by-suppressing-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#20
Xian-Tao Wang, Yuan-Xi Lu, Yu-Han Sun, Wen-Kai He, Jia-Bao Liang, Lang Li
BACKGROUND/AIMS: Myocardial apoptosis is heavily implicated in the myocardial injury caused by coronary microembolization (CME), and toll-like receptor 4 (TLR4) is considered to be involved in this apoptotic cascade. Therefore, the present study was designed to investigate the role of TLR4/NF-κB signaling pathway regulated by TAK-242, a selective TLR4 signal transduction inhibitor, in the myocardial apoptosis after CME in rats. METHODS: Forty-five rats were randomized (random number) into three groups: sham, CME and CME + TAK-242 (n = 15 per group)...
March 29, 2017: Cellular Physiology and Biochemistry
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