keyword
MENU ▼
Read by QxMD icon Read
search

Trigger points

keyword
https://www.readbyqxmd.com/read/29151105/eryptosis-the-neglected-cause-of-anemia-in-end-stage-renal-disease
#1
Florian Lang, Rosi Bissinger, Majed Abed, Ferruh Artunc
End stage renal disease (ESRD) invariably leads to anemia which has been mainly attributed to compromised release of erythropoietin from the defective kidneys with subsequent impairment of erythropoiesis. However, erythropoietin replacement only partially reverses anemia pointing to the involvement of additional mechanisms. As shown more recently, anemia of ESRD is indeed in large part a result of accelerated erythrocyte loss due to suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the cell surface...
October 23, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29149409/translationally-controlled-tumor-protein-tctp-hrf-in-animal-venoms
#2
Andrea Senff-Ribeiro
Proteins from TCTP/HRF family were identified as venom toxins of spiders from different genus. We have found a TCTP toxin in the venom gland of Loxosceles intermedia, a venomous spider very common in South Brazil. TCTP from L. intermedia, named LiTCTP, was cloned, produced in a heterologous prokaryotic system, and the recombinant toxin was biochemically characterized. Our results point that LiTCTP is involved in the inflammatory events of Loxocelism, the clinical signs triggered after Loxosceles sp. bite, which include intense inflammatory reaction at the bite site followed by local necrosis...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/29147057/lessons-learnt-during-20-years-of-the-swedish-strategic-programme-against-antibiotic-resistance
#3
Sigvard Mölstad, Sonja Löfmark, Karin Carlin, Mats Erntell, Olov Aspevall, Lars Blad, Håkan Hanberger, Katarina Hedin, Jenny Hellman, Christer Norman, Gunilla Skoog, Cecilia Stålsby-Lundborg, Karin Tegmark Wisell, Christina Åhrén, Otto Cars
Increasing use of antibiotics and rising levels of bacterial resistance to antibiotics are a challenge to global health and development. Successful initiatives for containing the problem need to be communicated and disseminated. In Sweden, a rapid spread of resistant pneumococci in the southern part of the country triggered the formation of the Swedish strategic programme against antibiotic resistance, also known as Strama, in 1995. The creation of the programme was an important starting point for long-term coordinated efforts to tackle antibiotic resistance in the country...
November 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29143406/oncogenic-spiral-by-infectious-pathogens-the-cooperation-of-multiple-factors-in-cancer-development
#4
Jun-Ichirou Yasunaga, Masao Matsuoka
Chronic infection is one of the major causes of cancer, and there are several mechanisms for infection-mediated oncogenesis. Some pathogens encode gene products that behave like oncogenic factors, hijacking cellular pathways to promote the survival and proliferation of infected cells in vivo. Some of these viral oncoproteins trigger a cellular damage defense response leading to senescence; however, other viral factors hinder this suppressive effect, suggesting that cooperation of those viral factors is important for malignant transformation...
November 15, 2017: Cancer Science
https://www.readbyqxmd.com/read/29141592/case-report-electrical-storm-during-induced-hypothermia-in-a-patient-with-early-repolarization
#5
Patrick Badertscher, Michael Kuehne, Beat Schaer, Christian Sticherling, Stefan Osswald, Tobias Reichlin
BACKGROUND: Population based studies showed an association of early repolarization in the electrocardiogram (ECG) and a higher rate of sudden cardiac death presumably due to ventricular fibrillation. The triggers for ventricular fibrillation in patients with early repolarization are not fully understood. CASE PRESENTATION: We describe the case of a young patient with a survived ventricular fibrillation arrest while asleep followed by multiple episodes of recurrent ventricular fibrillation...
November 15, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29141068/new-insight-into-the-pathophysiology-of-hair-loss-trigger-a-paradigm-shift-in-the-treatment-approach
#6
Neil S Sadick, Valerie D Callender, Leon H Kircik, Sophia Kogan
<p>Hair loss affects millions of men and women of all ages and ethnicities, impacting appearance, social interactions, and psycho-emotional well-being. Although a number of options are available, they are limited, carry a potential risk of side effects, and none have proven to be comprehensive for treatment of hair loss. Across the spectrum of hair loss disorders, there has long been a segmentation into distinct mechanisms, driving the main trend in current therapeutics to focus on targeting single molecules or pathways...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29140756/cellular-and-molecular-mechanisms-of-autoimmune-hepatitis
#7
G J Webb, G M Hirschfield, E L Krawitt, M E Gershwin
Autoimmune hepatitis is an uncommon idiopathic syndrome of immunemediated destruction of hepatocytes, typically associated with autoantibodies. The disease etiology is incompletely understood but includes a clear association with human leukocyte antigen (HLA) variants and other non- HLA gene variants, female sex, and the environment. Pathologically, there is a CD4+ T cell-rich lymphocytic inflammatory infiltrate with variable hepatocyte necrosis and subsequent hepatic fibrosis. Attempts to understand pathogenesis are informed by several monogenetic syndromes that may include autoimmune liver injury, by several drug and environmental agents that have been identified as triggers in a minority of cases, by human studies that point toward a central role for CD4+ effector and regulatory T cells, and by animal models of the disease...
November 15, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/29138476/visuospatial-attention-in-the-lateralised-brain-of-pigeons-a-matter-of-ontogenetic-light-experiences
#8
Sara Letzner, Onur Güntürkün, Stephanie Lor, Robert Jan Pawlik, Martina Manns
The ontogenetic mechanisms leading to complementary hemispheric specialisations of the two brain halves are poorly understood. In pigeons, asymmetrical light stimulation during development triggers the left-hemispheric dominance for visuomotor control but light effects on right-hemispheric specialisations are largely unknown. We therefore tested adult pigeons with and without embryonic light experience in a visual search task in which the birds pecked peas regularly scattered on an area in front of them. Comparing the pecking pattern of both groups indicates that the embryonic light conditions differentially influence biased visuospatial attention under mono- and binocular seeing conditions...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137729/the-shear-wave-elastic-modulus-and-the-increased-nuclear-factor-kappa-b-nf-kb-p65-and-cyclooxygenase-2-cox-2-expression-in-the-area-of-myofascial-trigger-points-activated-in-a-rat-model-by-blunt-trauma-to-the-vastus-medialis
#9
Hengyong Lv, Zhen Li, Tiantian Hu, Yuexiang Wang, Jinpeng Wu, Yingxin Li
We aimed to elucidate the increased inflammatory cytokines expression such as nuclear factor kappa B (NF-kB/p65), cyclooxygenase-2 (COX-2), and voltage-gated calcium channels (VGCC) in the area of activated myofascial trigger points (MTrPs) in a rat model by blunt trauma to the vastus medialis and to evaluate the feasibility of a quantitative analysis of muscle elastic modulus using shear wave elastography (SWE). Twelve 7-week-old male SD rats were divided into normal (NM, n = 6) and model groups (MO, n = 6)...
November 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29136633/impaired-enterohormone-response-following-a-liquid-test-meal-in-gastrectomized-patients
#10
Lidia Santarpia, Maria Carmen Pagano, Iolanda Cioffi, Lucia Alfonsi, Rosario Cuomo, Giuseppe Labruna, Lucia Sacchetti, Franco Contaldo, Fabrizio Pasanisi
BACKGROUND: Total gastrectomy (TG) is responsible for symptoms or disturbance of alimentary status (changes in body weight, food intake per meal and frequency of meal per day) which, in turn are responsible for weight loss and malnutrition. The study evaluates the gut hormone responses in totally gastrectomized (TG) patients after a liquid meal test. METHODS: Twenty total gastrectomized cancer-free patients (12 M, 8 F, 56.4 ± 10.2 years, BMI 21.4 ± 2.2 kg/m2) and 10 healthy volunteers (4 M, 6 F, 48...
November 14, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29136558/autonomous-vehicles-disengagements-trends-triggers-and-regulatory-limitations
#11
Francesca Favarò, Sky Eurich, Nazanin Nader
Autonomous Vehicle (AV) technology is quickly becoming a reality on US roads. Testing on public roads is currently undergoing, with many AV makers located and testing in Silicon Valley, California. The California Department of Motor Vehicles (CA DMV) currently mandates that any vehicle tested on California public roads be retrofitted to account for a back-up human driver, and that data related to disengagements of the AV technology be publicly available. Disengagements data is analyzed in this work, given the safety-critical role of AV disengagements, which require the control of the vehicle to be handed back to the human driver in a safe and timely manner...
November 11, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29136461/enzyme-free-nucleic-acid-amplification-assay-using-a-cellphone-based-well-plate-fluorescence-reader
#12
Donghyuk Kim, Qingshan Wei, Dong Hyeok Kim, Derek Tseng, Jingzi Zhang, Eric Pan, Omai Brandt Garner, Aydogan Ozcan, Dino Di Carlo
Nucleic acids, DNA and RNA, provide important fingerprint information for various pathogens and have significant diag-nostic value; however, improved approaches are urgently needed to enable rapid detection of nucleic acids in simple point-of-care formats with high sensitivity and specificity. Here, we present a system that utilizes a series of toehold-triggered hy-bridization/displacement reactions that are designed to convert a given amount of RNA molecules (i.e., the analyte) into an amplified amount of signaling molecules without any washing steps or thermocycling...
November 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29135338/convergent-and-divergent-signaling-in-pamp-triggered-immunity-and-effector-triggered-immunity
#13
Yujun Peng, Rowan van Wersch, Yuelin Zhang
Plants use diverse immune receptors to sense pathogen attacks. Recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors localized on the plasma membrane leads to PAMP-triggered immunity (PTI). Detection of pathogen effectors by intracellular or plasma membrane-localized immune receptors results in effector-triggered immunity (ETI). Despite the large variations in the magnitude and duration of immune responses triggered by different PAMPs or pathogen effectors during PTI and ETI, plasma membrane-localized immune receptors activate similar downstream molecular events such as MAP kinase activation, oxidative burst, ion influx and increased biosynthesis of plant defense hormones, indicating that defense signals initiated at the plasma membrane converge at later points...
November 14, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29133908/optically-controlled-long-term-storage-and-release-of-thermal-energy-in-phase-change-materials
#14
Grace G D Han, Huashan Li, Jeffrey C Grossman
Thermal energy storage offers enormous potential for a wide range of energy technologies. Phase-change materials offer state-of-the-art thermal storage due to high latent heat. However, spontaneous heat loss from thermally charged phase-change materials to cooler surroundings occurs due to the absence of a significant energy barrier for the liquid-solid transition. This prevents control over the thermal storage, and developing effective methods to address this problem has remained an elusive goal. Herein, we report a combination of photo-switching dopants and organic phase-change materials as a way to introduce an activation energy barrier for phase-change materials solidification and to conserve thermal energy in the materials, allowing them to be triggered optically to release their stored latent heat...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29131954/ultrafast-wiggling-and-jiggling-ir2-1-8-diisocyanomenthane-4-2
#15
Martin Pizl, Bryan M Hunter, Gregory M Greetham, Michael Towrie, Stanislav Zalis, Harry B Gray, Antonin Vlcek
Binuclear complexes of d8 metals (PtII, IrI, RhI, ) exhibit diverse photonic behavior including dual emission from relatively long-lived singlet and triplet excited states, as well as photochemical energy-, electron-, and atom transfer. Time-resolved optical spectroscopic and X-ray studies have revealed the behavior of the dimetallic core, confirming that M-M bonding is strengthened upon d*p excitation. We report the bridging ligand dynamics of Ir2(1,8-diisocyanomenthane)42+ (Ir(dimen)), investigated by fs-ns time-resolved IR spectroscopy (TRIR) in the region of CN stretching vibrations, (CN), 2000-2300 cm-1...
November 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29125184/hepatic-and-hippocampal-cytochrome-p450-enzyme-overexpression-during-spontaneous-recurrent-seizures
#16
Leonie Runtz, Benoit Girard, Marion Toussenot, Julie Espallergues, Alexis Fayd'Herbe De Maudave, Alexandre Milman, Frederic deBock, Chaitali Ghosh, Nathalie C Guérineau, Jean-Marc Pascussi, Federica Bertaso, Nicola Marchi
OBJECTIVE: Available evidence points to a role of cytochrome P450 (Cyp) drug biotransformation enzymes in central nervous system diseases, including epilepsy. Deviations in drug pharmacokinetic profiles may impact therapeutic outcomes. Here, we ask whether spontaneous recurrent seizure (SRS) activity is sufficient to modulate the expression of major Cyp enzymes in the liver and brain. METHODS: Unilateral intrahippocampal (IH) kainic acid (KA) injections were used to elicit nonconvulsive status epilepticus (SE), epileptogenesis, and SRS, as monitored by video-electroencephalography...
November 10, 2017: Epilepsia
https://www.readbyqxmd.com/read/29123195/specific-light-up-system-for-protein-and-metabolite-targets-triggered-by-initiation-complex-formation
#17
Hiroto Fujita, Yuka Kataoka, Remi Nagano, Yasuyo Nakajima, Masanobu Yamada, Naoki Sugimoto, Masayasu Kuwahara
Gene regulation systems are mimicked by simple quantitative detection of non-nucleic acid molecular targets such as protein and metabolite. Here, we describe a one-tube, one-step real-time quantitative detection methodology for isothermal signal amplification of those targets. Using this system, real-time quantitative detection of thrombin and streptomycin, which were used as examples for protein and metabolite targets, was successfully demonstrated with detection limits of at most 50 pM and 75 nM, respectively...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29121086/improved-segmented-modified-look-locker-inversion-recovery-t1-mapping-sequence-in-mice
#18
Maryam Nezafat, Isabel T Ramos, Markus Henningsson, Andrea Protti, Tamer Basha, René M Botnar
OBJECT: To develop and evaluate a 2D modified Look-Locker (MOLLI) for high-resolution T1 mapping in mice using a 3T MRI scanner. MATERIALS AND METHODS: To allow high-resolution T1 mapping in mice at high heart rates a multi-shot ECG-triggered 2D MOLLI sequence was developed. In the proposed T1 mapping sequence the optimal number of sampling points and pause cardiac cycles following an initial adiabatic inversion pulse was investigated in a phantom. Seven native control and eight mice, 3 days post myocardial infarction (MI) after administration of gadolinium were scanned...
2017: PloS One
https://www.readbyqxmd.com/read/29120705/effects-of-waterborne-cadmium-on-metabolic-rate-oxidative-stress-and-ion-regulation-in-the-freshwater-fish-inanga-galaxias-maculatus
#19
Nicole K McRae, Sally Gaw, Chris N Glover
The freshwater fish Galaxias maculatus (inanga) is a widespread Southern hemisphere species, but despite its habitation of lowland near-coastal waters with a high potential for cadmium contamination, nothing is known regarding its sensitivity to this toxic trace metal. Acute (96h) exposures were therefore performed to determine sublethal responses of inanga to waterborne cadmium at a regulatory trigger value (nominally 0.2μgL(-1); measured 1μgL(-1)), an environmental level (measured at 2.5μgL(-1)), and an effect level (measured at 10μgL(-1))...
October 31, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29118715/differential-regulation-of-thyroid-hormone-metabolism-target-genes-during-non-thyoidal-illness-syndrome-triggered-by-fasting-or-sepsis-in-adult-mice
#20
Klaus N Fontes, Adriana Cabanelas, Flavia F Bloise, Cherley Borba Vieira de Andrade, Luana L Souza, Marianna Wilieman, Isis H Trevenzoli, Lais C Agra, Johnatas D Silva, Christianne Bandeira-Melo, Pedro L Silva, Patricia R M Rocco, Tania M Ortiga-Carvalho
Fasting and sepsis induce profound changes in thyroid hormone (TH) central and peripheral metabolism. These changes affect TH action and are called the non-thyroidal illness syndrome (NTIS). To date, it is still debated whether NTIS represents an adaptive response or a real hypothyroid state at the tissue level. Moreover, even though it has been considered the same syndrome, we hypothesized that fasting and sepsis induce a distinct set of changes in thyroid hormone metabolism. Herein, we aimed to evaluate the central and peripheral expression of genes involved in the transport (MCT8/Slc16a2 and MCT10/Slc16a10), metabolism (Dio1, Dio2, and Dio3) and action (Thra and Thrb) of TH during NTIS induced by fasting or sepsis...
2017: Frontiers in Physiology
keyword
keyword
37937
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"