keyword
MENU ▼
Read by QxMD icon Read
search

Trigger points

keyword
https://www.readbyqxmd.com/read/28723513/the-natural-history-and-outcome-predictors-of-metastatic-castration-resistant-prostate-cancer
#1
REVIEW
Robert J van Soest, Jason A Efstathiou, Cora N Sternberg, Bertand Tombal
CONTEXT: Biomarkers for the treatment of metastatic castration-resistant prostate cancer (mCRPC) are urgently needed by clinicians to facilitate treatment decisions. OBJECTIVE: To review current prognostic and predictive biomarkers in mCRPC. EVIDENCE ACQUISITION: We performed a nonsystematic review of the literature from 2004 to August 2016 by searching in Medline. Cross-matching references were used to search for additional articles. We reviewed clinical research and review articles written in the English language...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28718822/a-bacterial-toxin-with-analgesic-properties-hyperpolarization-of-drg-neurons-by-mycolactone
#2
Ok-Ryul Song, Han-Byul Kim, Samuel Jouny, Isabelle Ricard, Alexandre Vandeputte, Nathalie Deboosere, Estelle Marion, Christophe J Queval, Pierre Lesport, Emmanuel Bourinet, Daniel Henrion, Seog Bae Oh, Guillaume Lebon, Guillaume Sandoz, Edouard Yeramian, Laurent Marsollier, Priscille Brodin
Mycolactone, a polyketide molecule produced by Mycobacterium ulcerans, is the etiological agent of Buruli ulcer. This lipid toxin is endowed with pleiotropic effects, presents cytotoxic effects at high doses, and notably plays a pivotal role in host response upon colonization by the bacillus. Most remarkably, mycolactone displays intriguing analgesic capabilities: the toxin suppresses or alleviates the pain of the skin lesions it inflicts. We demonstrated that the analgesic capability of mycolactone was not attributable to nerve damage, but instead resulted from the triggering of a cellular pathway targeting AT₂ receptors (angiotensin II type 2 receptors; AT₂R), and leading to potassium-dependent hyperpolarization...
July 18, 2017: Toxins
https://www.readbyqxmd.com/read/28715417/a-hox-complex-activates-and-potentiates-the-epidermal-growth-factor-signaling-pathway-to-specify-drosophila-oenocytes
#3
Guolun Wang, Lisa Gutzwiller, David Li-Kroeger, Brian Gebelein
Hox transcription factors specify distinct cell types along the anterior-posterior axis of metazoans by regulating target genes that modulate signaling pathways. A well-established example is the induction of Epidermal Growth Factor (EGF) signaling by an Abdominal-A (Abd-A) Hox complex during the specification of Drosophila hepatocyte-like cells (oenocytes). Previous studies revealed that Abd-A is non-cell autonomously required to promote oenocyte fate by directly activating a gene (rhomboid) that triggers EGF secretion from sensory organ precursor (SOP) cells...
July 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28715296/a-self-determination-theory-based-self-myofascial-release-program-in-older-adults-with-myofascial-trigger-points-in-the-neck-and-back-a-pilot-study
#4
Minyoung Lee, Minhee Kim, Sejun Oh, Yoon-Jin Choi, Dongshin Lee, Sang Heon Lee, BumChul Yoon
PURPOSE: To examine the effectiveness and adherence to a self-determination theory (SDT)-based self-myofascial release (SMR) program in older adults with myofascial trigger points (MTrPs), and to investigate the factors that influence participant behavioral change while conducting the program in a home setting. METHODS: An explanatory mixed-method design was used to evaluate a 12-week SDT-based SMR program, including a 4-week group-based education and practice (EP) phase and an 8-week home-based self-management (SM) phase...
July 17, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28714983/tunable-room-temperature-magnetic-skyrmions-in-ir-fe-co-pt-multilayers
#5
Anjan Soumyanarayanan, M Raju, A L Gonzalez Oyarce, Anthony K C Tan, Mi-Young Im, A P Petrović, Pin Ho, K H Khoo, M Tran, C K Gan, F Ernult, C Panagopoulos
Magnetic skyrmions are nanoscale topological spin structures offering great promise for next-generation information storage technologies. The recent discovery of sub-100-nm room-temperature (RT) skyrmions in several multilayer films has triggered vigorous efforts to modulate their physical properties for their use in devices. Here we present a tunable RT skyrmion platform based on multilayer stacks of Ir/Fe/Co/Pt, which we study using X-ray microscopy, magnetic force microscopy and Hall transport techniques...
July 17, 2017: Nature Materials
https://www.readbyqxmd.com/read/28714393/interrelationships-between-gut-microbiota-and-host-paradigms-role-in-neurodegenerative-diseases-and-future-prospects
#6
Javier Caballero- Villarraso, Alberto Galvan, Begoña M Escribano, Isaac Túnez
Advances in the knowledge of the microbiota and concepts related to it have triggered a wake-up call in biomedicine. The development in various scientific areas has enabled a better and broader approach to everything concerning the set of families of microorganisms that coexist with an individual and are able to function as one more organ in its body. Among the aforementioned scientific areas, those worth mentioning are the advances/progress in biotechnological resources and, in particular, molecular biology and related areas...
July 14, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28713981/neuroendocrine-factors-the-missing-link-in-non%C3%A2-melanoma-skin-cancer-review
#7
Mihai Lupu, Ana Caruntu, Constantin Caruntu, Laura Maria Lucia Papagheorghe, Mihaela Adriana Ilie, Vlad Voiculescu, Daniel Boda, Constantin Carolina, Cristiana Tanase, Maria Sifaki, Nikolaos Drakoulis, Charalampos Mamoulakis, George Tzanakakis, Monica Neagu, Demetrios A Spandidos, Boris N Izotov, Aristides M Tsatsakis
Non‑melanoma skin cancer (NMSC) is the most common form of cancer worldwide, comprising 95% of all cutaneous malignancies and approximately 40% of all cancers. In spite of intensive efforts aimed towards awareness campaigns and sun‑protective measures, epidemiological data indicate an increase in the incidence of NMSC. This category of skin cancers has many common environmental triggers. Arising primarily on sun‑exposed skin, it has been shown that ultraviolet radiation is, in the majority of cases, the main trigger involved in the pathogenesis of NMSC...
July 13, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28710693/driving-cancer-tumorigenesis-and-metastasis-through-upr-signaling
#8
Alexandra Papaioannou, Eric Chevet
In the tumor microenvironment, cancer cells encounter both external and internal factors that can lead to the accumulation of improperly folded proteins in the Endoplasmic Reticulum (ER) lumen, thus causing ER stress. When this happens, an adaptive mechanism named the Unfolded Protein Response (UPR) is triggered to help the cell cope with this change and restore protein homeostasis in the ER. Sequentially, one would expect that the activation of the three UPR branches, driven namely by IRE1, PERK, and ATF6, are crucial for the adaptation of cancer cells to the changing environment and thus for their survival and further propagation...
July 15, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28710588/identification-and-molecular-characterization-of-a-trans-acting-small-interfering-rna-producing-locus-regulating-leaf-rust-responsive-gene-expression-in-wheat-triticum-aestivum-l
#9
Summi Dutta, Dhananjay Kumar, Shailendra Jha, Kumble Vinod Prabhu, Manish Kumar, Kunal Mukhopadhyay
A novel leaf rust responsive ta-siRNA-producing locus was identified in wheat showing similarity to 28S rRNA and generated four differentially expressing ta-siRNAs by phasing which targeted stress responsive genes. Trans-acting-small interfering RNAs (Ta-siRNAs) are plant specific molecules generally involved in development and are also stress responsive. Ta-siRNAs identified in wheat till date are all responsive to abiotic stress only. Wheat cultivation is severely affected by rusts and leaf rust particularly affects grain filling...
July 14, 2017: Planta
https://www.readbyqxmd.com/read/28710392/comparative-study-of-arabidopsis-pbs1-and-a-wheat-pbs1-homolog-helps-understand-the-mechanism-of-pbs1-functioning-in-innate-immunity
#10
Jianhang Sun, Guozhong Huang, Fenggui Fan, Shuangfeng Wang, Yingying Zhang, Yufang Han, Yanmin Zou, Dongping Lu
Arabidopsis AVRPPHB SUSCEPTIBLE1 (PBS1) serves as a "decoy" in activating RESISTANCE TO PSEUDOMONAS SYRINGAE5 (RPS5) upon cleavage by Pseudomonas phaseolicola B (AvrPphB), a Pseudomonas syringae effector. The SEMPH motif in PBS1 was thought to allow it to be distinguished by RPS5 from the closely related Arabidopsis kinases. However, the underlying mechanism is not fully understood. Here, we isolated and characterized a wheat PBS1 homolog, TaPBS1. Although this plasma membrane-localized kinase could be cleaved by AvrPphB and could associate with RPS5, it failed to trigger RPS5-mediated hypersensitive response (HR) in a transient assay...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708724/impact-of-ssf-on-diagnostic-performance-of-coronary-computed-tomography-angiography-within-1-heart-beat-in-patients-with-high-heart-rate-using-a-256-row-detector-computed-tomography
#11
Junfu Liang, Hui Wang, Lei Xu, Li Dong, Zhanming Fan, Rui Wang, Zhonghua Sun
OBJECTIVE: The aim of this study was to investigate the impact of a motion-correction algorithm on diagnostic accuracy of coronary computed tomography angiography (CCTA) within 1 heart beat in patients with high heart rate (HR) using a 256-row detector CT. METHOD: Sixty-four consecutive patients with known or suspected coronary artery disease (symptomatic) and with HR of 75 beats per minute or greater (mean [SD] HR, 82.6 [7.3] beats per minute) undergoing CCTA and invasive coronary angiography within 4 weeks were prospectively enrolled...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28708120/on-operating-a-nanofiltration-membrane-for-olive-mill-wastewater-purification-at-sub-and-super-boundary-conditions
#12
Marco Stoller, Javier Miguel Ochando-Pulido, Robert Field
In the last decades, membrane processes have gained a significant share of the market for wastewater purification. Although the product (i.e., purified water) is not of high added value, these processes are feasible both technically and from an economic point of view, provided the flux is relatively high and that membrane fouling is strongly inhibited. By controlling membrane fouling, the membrane may work for years without service, thus dramatically reducing operating costs and the need for membrane substitution...
July 14, 2017: Membranes
https://www.readbyqxmd.com/read/28702143/cxcr4-expression-is-associated-with-time-course-permanent-and-temporary-myocardial-infarction-in-rats
#13
Ali Asghar Kiani, Fereshteh Babaei, Mehrnoosh Sedighi, Azam Soleimani, Kolsum Ahmadi, Somayeh Shahrokhi, Khatereh Anbari, Afshin Nazari
OBJECTIVES: Experimental myocardial infarction triggers secretion of Stromal cell-derived factor1 and lead to increase in the expression of its receptor "CXCR4" on the surface of various cells. The aim of this study was to evaluate the expression pattern of CXCR4 in peripheral blood cells following time-course permanent and temporary ischemia in rats. MATERIALS AND METHODS: Fourteen male Wistar rats were divided into two groups of seven and were placed under permanent and transient ischemia...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28702038/neofusicoccum-parvum-colonization-of-the-grapevine-woody-stem-triggers-asynchronous-host-responses-at-the-site-of-infection-and-in-the-leaves
#14
Mélanie Massonnet, Rosa Figueroa-Balderas, Erin R A Galarneau, Shiho Miki, Daniel P Lawrence, Qiang Sun, Christopher M Wallis, Kendra Baumgartner, Dario Cantu
Grapevine trunk diseases cause important economic losses in vineyards worldwide. Neofusicoccum parvum, one of the most aggressive causal agents of the trunk disease Botryosphaeria dieback, colonizes cells and tissues of the grapevine wood, leading to the formation of an internal canker. Symptoms then extend to distal shoots, with wilting of leaves and bud mortality. Our aim was to characterize the transcriptional dynamics of grapevine genes in the woody stem and in the leaves during Neofusicoccum parvum colonization...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28701927/activation-of-the-creb-c-fos-pathway-during-long-term-synaptic-plasticity-in-the-cerebellum-granular-layer
#15
Daniela Gandolfi, Silvia Cerri, Jonathan Mapelli, Mariarosa Polimeni, Simona Tritto, Marie-Therese Fuzzati-Armentero, Albertino Bigiani, Fabio Blandini, Lisa Mapelli, Egidio D'Angelo
The induction of long-term potentiation and depression (LTP and LTD) is thought to trigger gene expression and protein synthesis, leading to consolidation of synaptic and neuronal changes. However, while LTP and LTD have been proposed to play important roles for sensori-motor learning in the cerebellum granular layer, their association with these mechanisms remained unclear. Here, we have investigated phosphorylation of the cAMP-responsive element binding protein (CREB) and activation of the immediate early gene c-Fos pathway following the induction of synaptic plasticity by theta-burst stimulation (TBS) in acute cerebellar slices...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28701056/effects-of-polyhexamethylene-guanidine-phosphate-on-human-gingival-fibroblasts
#16
Anton Vitt, Veronica Slizen, Elisabeth A Boström, Tülay Yucel-Lindberg, Anna Kats, Rachael V Sugars, Anders Gustafsson, Kåre Buhlin
OBJECTIVE: Polyhexamethylene guanidine phosphate (PHMG-P) was compared to chlorhexidine (CHX) in order to determine potential cytotoxic and immune-modulatory effects on human gingival fibroblasts. MATERIALS AND METHODS: Cytotoxic effects of PHMG-P and CHX on human gingival fibroblasts were assessed using cell viability assay at various time points and concentrations. The effects of PHMG-P and CHX on the secretion of prostaglandin (PG) E2, interleukin (IL)-6, IL-8 and matrix metalloproteinase (MMP)-1 by non-stimulated or IL-1β stimulated fibroblasts were evaluated by enzyme-linked immunosorbent assays...
July 12, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28698597/selenoprotein-msrb1-promotes-anti-inflammatory-cytokine-gene-expression-in-macrophages-and-controls-immune-response-in-vivo
#17
Byung Cheon Lee, Sang-Goo Lee, Min-Kyung Choo, Ji Hyung Kim, Hae Min Lee, Sorah Kim, Dmitri E Fomenko, Hwa-Young Kim, Jin Mo Park, Vadim N Gladyshev
Post-translational redox modification of methionine residues often triggers a change in protein function. Emerging evidence points to this reversible protein modification being an important regulatory mechanism under various physiological conditions. Reduction of oxidized methionine residues is catalyzed by methionine sulfoxide reductases (Msrs). Here, we show that one of these enzymes, a selenium-containing MsrB1, is highly expressed in immune-activated macrophages and contributes to shaping cellular and organismal immune responses...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28697663/the-point-mutation-g461s-in-the-mfcyp51-gene-is-associated-with-tebuconazole-resistance-in-monilinia-fructicola-populations-in-brazil
#18
Paulo Santos Faria Lichtemberg, Yong Luo, Rafael G Morales, Juliana Marta Muehlmann Fischer, Themis J Michailides, Louise Larissa May De Mio
The ascomycete Monilinia fructicola is the causal agent of brown rot of stone fruits in Brazil, causing major pre- and post-harvest losses. For many years, the demethylation inhibitor fungicide tebuconazole has been used as the most effective active ingredient for controlling brown rot, and as a result, strains of M. fructicola resistant to this ingredient have emerged in many Brazilian States producing stone fruits. The aim of this study was to investigate the mechanism(s) associated with the resistance of M...
July 11, 2017: Phytopathology
https://www.readbyqxmd.com/read/28697218/a-1-colloidal-oatmeal-cream-alone-is-effective-in-reducing-symptoms-of-mild-to-moderate-atopic-dermatitis-results-from-two-clinical-studies
#19
Toni Anne Lisante, Chris Nunez, Paul Zhang, Barbara M Mathes
<p>BACKGROUND: The epidermal barrier in patients with atopic dermatitis (AD) is deficient in ceramides and cathelicidins. Such epidermal defects may be a trigger for AD, thereby encouraging research toward development of skin-barrier-targeted preventive strategies.</p> <p>METHODS: Two single-center, single-arm clinical trials were conducted (study 1, age greater than equal to 8 years and study 2, greater than equal to 10 years) in patients with mild to moderate AD to evaluate the effects of an over-the-counter 1% colloidal oatmeal cream administered for 14 days...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28696429/glud1-linked-to-schizophrenia-controls-the-burst-firing-of-dopamine-neurons
#20
N Benamer, F Marti, R Lujan, R Hepp, T G Aubier, A A M Dupin, G Frébourg, S Pons, U Maskos, P Faure, Y A Hay, B Lambolez, L Tricoire
Human mutations of the GRID1 gene encoding the orphan delta1 glutamate receptor-channel (GluD1) are associated with schizophrenia but the explicit role of GluD1 in brain circuits is unknown. Based on the known function of its paralog GluD2 in cerebellum, we searched for a role of GluD1 in slow glutamatergic transmission mediated by metabotropic receptor mGlu1 in midbrain dopamine neurons, whose dysfunction is a hallmark of schizophrenia. We found that an mGlu1 agonist elicits a slow depolarizing current in HEK cells co-expressing mGlu1 and GluD1, but not in cells expressing mGlu1 or GluD1 alone...
July 11, 2017: Molecular Psychiatry
keyword
keyword
37937
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"