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https://www.readbyqxmd.com/read/28098584/interrater-agreement-of-manual-palpation-for-identification-of-myofascial-trigger-points-a-systematic-review-and-meta-analysis
#1
Alasdair T L Rathbone, Liza Grosman-Rimon, Dinesh A Kumbhare
OBJECTIVE: To achieve a statistical estimate of the agreement of manual palpation for identification of myofascial trigger points (MTrPs) and secondarily to investigate potential factors impacting the agreement of this technique. METHODS: We searched MEDLINE(R) and Embase for studies examining the reproducibility of manual palpation for the identification of MTrPs from the year 2007 to present. In addition, we utilized studies identified by 2 comprehensive systematic reviews that covered the period before 2007...
January 17, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28090258/echocardiographic-and-histologic-correlations-in-patients-with-severe-aortic-stenosis-influence-of-overweight-and-obesity
#2
Nydia Ávila-Vanzzini, Juan Francisco Fritche-Salazar, Nelva Marina Vázquez-Castro, Pedro Rivera-Lara, Oscar Pérez-Méndez, Humberto Martínez-Herrera, Mario Gómez-Sánchez, Alberto Aranda-Frausto, Héctor Herrera-Bello, María Luna-Luna, José Antonio Arias Godínez
BACKGROUND: Severe aortic stenosis (AS), leads to pathological left ventricular remodeling that may worsen with concomitant overweight and obesity (OW/O). METHODS: We aimed to prospectively analyze the impact of OW/O on ventricular remodeling in severe AS, by evaluating the percentage of intraendomyocardial fibrosis (PIEF) and the percentage of infiltrating intraendocardial lipid vacuoles (PIELV) and its relationship to global longitudinal strain (GLS) in patients with OW/O...
December 2016: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28089741/inflammatory-myopathy-in-a-patient-with-aicardi-gouti%C3%A3-res-syndrome
#3
Birutė Tumienė, Norine Voisin, Eglė Preikšaitienė, Donatas Petroška, Jurgita Grikinienė, Rūta Samaitienė, Algirdas Utkus, Alexandre Reymond, Vaidutis Kučinskas
Aicardi-Goutières syndrome (AGS) is an inflammatory disorder belonging to the recently characterized group of type I interferonopathies. The most consistently affected tissues in AGS are the central nervous system and skin, but various organ systems and tissues have been reported to be affected, pointing to the systemic nature of the disease. Here we describe a patient with AGS due to a homozygous p.Arg114His mutation in the TREX1 gene. The histologically proven inflammatory myopathy in our patient expands the range of clinical features of AGS...
January 9, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28087088/discharge-teaching-readiness-for-discharge-and-post-discharge-outcomes-in-parents-of-hospitalized-children
#4
Marianne E Weiss, Kathleen J Sawin, Karen Gralton, Norah Johnson, Carol Klingbeil, Stacee Lerret, Shelly Malin, Olga Yakusheva, Rachel Schiffman
PURPOSE: This study explored the sequential relationships of parent perceptions of the quality of their discharge teaching and nurse and parent perceptions of discharge readiness to post-discharge outcomes (parental post-discharge coping difficulty, readmission and emergency department visits). DESIGN/METHODS: In this secondary analysis of data from a longitudinal pilot study of family self-management discharge preparation, the correlational design used regression modeling with data from a convenience sample of 194 parents from two clinical units at a Midwest pediatric hospital...
January 10, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28086920/absence-of-system-xc-on-immune-cells-invading-the-central-nervous-system-alleviates-experimental-autoimmune-encephalitis
#5
Ellen Merckx, Giulia Albertini, Magdalena Paterka, Cathy Jensen, Philipp Albrecht, Michael Dietrich, Joeri Van Liefferinge, Eduard Bentea, Lise Verbruggen, Thomas Demuyser, Lauren Deneyer, Jan Lewerenz, Geert van Loo, Jacques De Keyser, Hideyo Sato, Pamela Maher, Axel Methner, Ann Massie
BACKGROUND: Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points to a key role for neuroinflammation, oxidative stress, and excitotoxicity in this degenerative process. System xc(-) or the cystine/glutamate antiporter could tie these pathological mechanisms together: its activity is enhanced by reactive oxygen species and inflammatory stimuli, and its enhancement might lead to the release of toxic amounts of glutamate, thereby triggering excitotoxicity and neurodegeneration...
January 13, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28081456/robust-tough-and-anti-fatigue-cationic-latex-composite-hydrogels-based-on-dual-physically-cross-linked-networks
#6
Song Gu, Lijie Duan, Xiuyan Ren, Guang Hui Gao
Dual physically cross-linked hydrogels, which are triggered by cationic latexes as hydrophobic association and ionic crosslinking centers, were easily fabricated via a one-pot in situ polymerization method. First, the hydrophobic alkyl chains of hydrophobic monomers are adsorbed on the surface of latex microspheres and stabilized in the presence of surfactants, forming hydrophobic association centers as the first physical crosslinking points. Meanwhile, the anionic sulfate radicals dissociated by persulphate are attracted towards the cationic molecular chains of latex microspheres through ionic interactions, forming the secondary physical crosslinking centers, and initiate the copolymerization between acrylamide and hydrophobic vinyl monomers...
January 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28081273/assessing-the-impact-of-retreat-mechanisms-in-a-simple-antarctic-ice-sheet-model-using-bayesian-calibration
#7
Kelsey L Ruckert, Gary Shaffer, David Pollard, Yawen Guan, Tony E Wong, Chris E Forest, Klaus Keller
The response of the Antarctic ice sheet (AIS) to changing climate forcings is an important driver of sea-level changes. Anthropogenic climate change may drive a sizeable AIS tipping point response with subsequent increases in coastal flooding risks. Many studies analyzing flood risks use simple models to project the future responses of AIS and its sea-level contributions. These analyses have provided important new insights, but they are often silent on the effects of potentially important processes such as Marine Ice Sheet Instability (MISI) or Marine Ice Cliff Instability (MICI)...
2017: PloS One
https://www.readbyqxmd.com/read/28076396/neutrophil-interactions-stimulate-evasive-hyphal-branching-by-aspergillus-fumigatus
#8
Felix Ellett, Julianne Jorgensen, Galit H Frydman, Caroline N Jones, Daniel Irimia
Invasive aspergillosis (IA), primarily caused by Aspergillus fumigatus, is an opportunistic fungal infection predominantly affecting immunocompromised and neutropenic patients that is difficult to treat and results in high mortality. Investigations of neutrophil-hypha interaction in vitro and in animal models of IA are limited by lack of temporal and spatial control over interactions. This study presents a new approach for studying neutrophil-hypha interaction at single cell resolution over time, which revealed an evasive fungal behavior triggered by interaction with neutrophils: Interacting hyphae performed de novo tip formation to form new hyphal branches, allowing the fungi to avoid the interaction point and continue invasive growth...
January 11, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28074927/quaternary-climate-change-drives-allo-peripatric-speciation-and-refugial-divergence-in-the-dysosma-versipellis-pleiantha-complex-from-different-forest-types-in-china
#9
Yi-Han Wang, Hans Peter Comes, Ya-Nan Cao, Rui Guo, Yun-Rui Mao, Ying-Xiong Qiu
Subtropical China harbours the world's most diverse temperate flora, but little is known about the roles of geographical and eco-climatic factors underlying the region's exceptionally high levels of species diversity and endemism. Here we address this key question by investigating the spatio-temporal and ecological processes of divergence within the Dysosma versipellis-pleiantha species complex, endemic to subtropical China. Our cpDNA phylogeny showed that this monophyletic group of understory herbs is derived from a Late Pliocene ancestor of the Qinghai-Tibetan Plateau (QTP)/Southwest China...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28073160/activation-of-jnk-pathway-aggravates-proteotoxicity-of-hepatic-mutant-z-alpha1-antitrypsin
#10
Nunzia Pastore, Sergio Attanasio, Barbara Granese, Jeffrey Teckman, Andrew A Wilson, Andrea Ballabio, And Nicola Brunetti-Pierri
Alpha1-antitrypsin deficiency is a genetic disease that can affect both the lung and the liver. The vast majority of patients harbor a mutation in the SERPINA1 gene resulting in a single amino acid substitution that results in an unfolded protein that is prone to polymerization. Therefore, the liver disease is caused by a gain of function mechanism due to accumulation of the mutant Z alpha1-antitrypsin (ATZ) and is a key example of an important disease mechanism induced by protein toxicity. Intracellular retention of ATZ triggers a complex injury cascade including apoptosis and other mechanisms, although several aspects of the disease pathogenesis are still unclear...
January 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28071716/lytic-polysaccharide-monooxygenases-disrupt-the-cellulose-fibers-structure
#11
Ana Villares, Céline Moreau, Chloé Bennati-Granier, Sona Garajova, Loïc Foucat, Xavier Falourd, Bodo Saake, Jean-Guy Berrin, Bernard Cathala
Lytic polysaccharide monooxygenases (LPMOs) are a class of powerful oxidative enzymes that breakdown recalcitrant polysaccharides such as cellulose. Here we investigate the action of LPMOs on cellulose fibers. After enzymatic treatment and dispersion, LPMO-treated fibers show intense fibrillation. Cellulose structure modifications visualized at different scales indicate that LPMO creates nicking points that trigger the disintegration of the cellulose fibrillar structure with rupture of chains and release of elementary nanofibrils...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28068679/-pneumothorax-following-dry-needling-treatment-legal-and-ethical-aspects
#12
Gianpaolo Ronconi, Fabio De Giorgio, Eleonora Ricci, Loredana Maggi, Antonio G Spagnolo, Paola Emilia Ferrara
Trigger point "dry needling" is a technique used to treat myofascial pain. It involves using filiform needles which are inserted into muscles to give local pain relief. Few cases of serious adverse events following this treatment have been reported in the literature. In this paper we describe the case of a professional swimmer who developed pneumothorax after dry needling treatment and discuss the medicolegal and ethical aspects related to competencies and responsibilities of medical doctors and physiotherapists performing the procedure...
September 2016: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28067393/longitudinal-assessment-of-metal-concentrations-and-copper-isotope-ratios-in-the-g93a-sod1-mouse-model-of-amyotrophic-lateral-sclerosis
#13
T Gabriel Enge, Heath Ecroyd, Dianne F Jolley, Justin J Yerbury, Anthony Dosseto
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, which involves progressive motor neuron degeneration in the central nervous system (CNS). The G93A SOD1 mouse model simulates one of the most common causes of familial ALS through the overexpression of a mutated form of the human gene encoding copper/zinc superoxide dismutase (SOD1). Transition metals, particularly Cu and Zn, have been shown to behave abnormally in the disease context and have been hypothesized to contribute to and potentially trigger the disease...
January 9, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28065671/glutamine-triggers-long-lasting-increase-in-striatal-network-activity-in-vitro
#14
Wiebke Fleischer, Stephan Theiss, Alfons Schnitzler, Olga Sergeeva
Accumulation of ammonium and glutamine in blood and brain is a key factor in hepatic encephalopathy (HE) - a neuropsychiatric syndrome characterized by various cognitive and motor deficits. MRI imaging identified abnormalities notably in the basal ganglia of HE patients, including its major input station, the striatum. While neurotoxic effects of ammonia have been extensively studied, glutamine is primarily perceived as "detoxified" form of ammonia. We applied ammonium and glutamine to striatal and cortical cells from newborn rats cultured on microelectrode arrays...
January 6, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28065662/hot-heads-cool-bodies-the-conundrums-of-human-bat-activity-research
#15
REVIEW
Lonneke Bahler, Frits Holleman, Jan Booij, Joost B Hoekstra, Hein J Verberne
Brown adipose tissue is able to increase energy expenditure by converting glucose and fatty acids into heat. Therefore, BAT is able to increase energy expenditure and could thereby facilitate weight loss or at least weight maintenance. Since cold is a strong activator of BAT, most prospective research is performed during cold to activate BAT. In current research, there are roughly two methods of cooling. Cooling by lowering ambient air temperature, which uses a fixed temperature for all subjects and personalized cooling, which uses cooling blankets or vests with temperatures that can be adjusted to the individual set point of shivering...
January 5, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28063838/exploring-and-understanding-the-functional-role-and-biochemical-and-structural-characteristics-of-an-acidic-phospholipase-a2-apltx-i-purified-from-agkistrodon-piscivorus-leucostoma-snake-venom
#16
L M Resende, J R Almeida, R Schezaro-Ramos, R C O Collaço, L R Simioni, D Ramírez, W González, A M Soares, L A Calderon, S Marangoni, S L da Silva
Phospholipases A2 (PLA2s) constitute a class of extensively studied toxins, isolated from snake venoms. Basic PLA2 isoforms mediate various toxicological effects, while the acidic isoforms generally have higher enzymatic activities, but do not promote evident toxic effects. The functions of these acidic isoforms in snake venoms are still not completely understood and more studies are needed to characterize the biological functions and diversification of acidic toxins in order to justify their abundant presence in these secretions...
January 4, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28062698/monoclonal-antibodies-against-epidermal-growth-factor-receptor-acquire-an-ability-to-kill-tumor-cells-through-complement-activation-by-mutations-that-selectively-facilitate-the-hexamerization-of-igg-on-opsonized-cells
#17
Annalina Tammen, Stefanie Derer, Ralf Schwanbeck, Thies Rösner, Anna Kretschmer, Frank J Beurskens, Janine Schuurman, Paul W H I Parren, Thomas Valerius
Triggering of the complement cascade induces tumor cell lysis via complement-dependent cytotoxicity (CDC) and attracts and activates cytotoxic cells. It therefore represents an attractive mechanism for mAb in cancer immunotherapy development. The classical complement pathway is initiated by IgG molecules that have assembled into ordered hexamers after binding their Ag on the tumor cell surface. The requirements for CDC are further impacted by factors such as Ab epitope, valency, and affinity. Thus, mAb against well-validated solid tumor targets, such as the epidermal growth factor receptor (EGFR) that effectively induces complement activation and CDC, are highly sought after...
January 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28062374/proteomic-analysis-of-the-rett-syndrome-experimental-model-mecp2-q63x-mutant-zebrafish
#18
Alessio Cortelazzo, Thomas Pietri, Claudio De Felice, Silvia Leoncini, Roberto Guerranti, Cinzia Signorini, Anna Maria Timperio, Lello Zolla, Lucia Ciccoli, Joussef Hayek
: Rett syndrome (RTT) is a severe genetic disorder resulting from mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene. Recently, a zebrafish carrying a mecp2-null mutation has been developed with the resulting phenotypes exhibiting defective sensory and thigmotactic responses, and abnormal motor behavior reminiscent of the human disease. Here, we performed a proteomic analysis to examine protein expression changes in mecp2-null vs. wild-type larvae and adult zebrafish...
January 3, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28057341/the-impact-of-agricultural-management-on-selected-soil-properties-in-citrus-orchards-in-eastern-spain-a-comparison-between-conventional-and-organic-citrus-orchards-with-drip-and-flood-irrigation
#19
M A Hondebrink, L H Cammeraat, A Cerdà
The agricultural management of citrus orchards is changing from flood irrigated managed orchards to drip irrigated organic managed orchards. Eastern Spain is the oldest and largest European producer of citrus, and is representative of the environmental changes triggered by innovations in orchard management. In order to determine the impact of land management on different soil quality parameters, twelve citrus orchards sites were selected with different land and irrigation management techniques. Soil samples were taken at two depths, 0-2cm and 5-10cm for studying soil quality parameters under the different treatments...
January 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28056759/should-we-be-concerned-about-the-inflammatory-response-to-endovascular-procedures
#20
Djordje Radak, Nenad Djukic, Slobodan Tanaskovic, Milan Obradovic, Desanka Cenic-Milosevic, Esma R Isenovic
Endovascular surgery represents a minimally invasive procedure for the treatment of occlusive and aneurysmal arterial disease. However, it is followed by inflammatory response, with a rise in specific inflammatory biomarkers, such as C-reactive protein, serum amyloid A and fibrinogen. Shear stress during balloon inflation and vascular injury represents triggering events for the inflammatory process, stimulating the production of proinflammatory molecules and activation of circulating monocytes. The current literature indicates that stent implantation induces more prominent inflammatory reaction...
January 5, 2017: Current Vascular Pharmacology
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