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https://www.readbyqxmd.com/read/29775087/does-armodafinil-improve-driving-task-performance-and-weight-loss-in-sleep-apnea-a-randomized-trial
#1
Julia Louise Chapman, Elizabeth Anne Cayanan, Camilla Miranda Hoyos, Yasmina Serinel, Maria Comas, Brendon John Yee, Keith Keat Huat Wong, Ronald Robert Grunstein, Nathaniel Stuart Marshall
RATIONALE Obstructive sleep apnea (OSA) patients unable to tolerate standard treatments have few alternatives. They may benefit from weight loss, but the major symptom of daytime performance impairment may remain during weight loss programs. OBJECTIVES We hypothesized that wakefulness-promoter armodafinil would improve driving task performance over placebo in patients undergoing weight loss. METHODS Placebo-controlled, double-blind, randomized trial of Armodafinil vs Placebo daily for 6 months in patients who were also randomized to one of two diets for six months with follow-up at one year in overweight, adult, OSA patients who had rejected standard treatment and suffered daytime sleepiness...
May 18, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29773530/alcohol-consumption-reduction-among-a-web-based-supportive-community-using-the-hello-sunday-morning-blog-platform-observational-study
#2
Jessica Jane Louise Kirkman, Briony Leo, Jamie Christopher Moore
BACKGROUND: Alcohol misuse is a major social and public health issue in Australia, with an estimated cost to the community of Aus $30 billion per annum. Until recently, a major barrier in addressing this significant public health issue is the fact that the majority of individuals with alcohol use disorders and alcohol misuse are not receiving treatment. OBJECTIVE: This study aimed to assess whether alcohol consumption changes are associated with participation in Hello Sunday Morning's blog platform, an online forum discussing experiences in abstaining from alcohol...
May 17, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29771574/is-adding-maternal-vaccination-to-prevent-whooping-cough-cost-effective-in-australia
#3
Laure-Anne Van Bellinghen, Alex Dimitroff, Michael Haberl, Xiao Li, Andrew Manton, Karen Moeremans, Nadia Demarteau
Pertussis or whooping cough, a highly infectious respiratory infection, causes significant morbidity and mortality in infants. In adolescents and adults, pertussis presents with atypical symptoms often resulting in under-diagnosis and under-reporting, increasing the risk of transmission to more vulnerable groups. Maternal vaccination against pertussis protects mothers and newborns. This evaluation assessed the cost-effectiveness of adding maternal dTpa (reduced antigen diphtheria, Tetanus, acellular pertussis) vaccination to the 2016 nationally-funded pertussis program (DTPa [Diphtheria, Tetanus, acellular Pertussis] at 2, 4, 6, 18 months, 4 years and dTpa at 12-13 years) in Australia...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29770313/management-of-the-axilla-in-metaplastic-breast-carcinoma
#4
Brittany L Murphy, Robert T Fazzio, Tanya L Hoskin, Katrina N Glazebrook, Michael G Keeney, Elizabeth B Habermann, Tina J Hieken
Background: Metaplastic breast cancer (MBC), characterized by admixed epithelial, squamous or mesenchymal elements, constitutes <1% of breast cancers and has a poor prognosis but a paradoxically low reported rate of axillary lymph node (LN) involvement. Due to its rarity, data on appropriate axillary management is lacking, prompting this investigation of LN status and outcomes. Methods: We identified 41 MBC patients treated at our institution 2001-2011 who were followed for a median of 66 months...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29758397/discrimination-between-smiling-faces-human-observers-vs-automated-face-analysis
#5
Mario Del Líbano, Manuel G Calvo, Andrés Fernández-Martín, Guillermo Recio
This study investigated (a) how prototypical happy faces (with happy eyes and a smile) can be discriminated from blended expressions with a smile but non-happy eyes, depending on type and intensity of the eye expression; and (b) how smile discrimination differs for human perceivers versus automated face analysis, depending on affective valence and morphological facial features. Human observers categorized faces as happy or non-happy, or rated their valence. Automated analysis (FACET software) computed seven expressions (including joy/happiness) and 20 facial action units (AUs)...
May 11, 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29757723/ct-and-mr-imaging-features-of-artificial-urinary-sphincters-penile-prostheses-and-other-devices-in-the-male-lower-genitourinary-tract
#6
Elizabeth T Chorney, Parvati Ramchandani, William I Jaffe, Evan S Siegelman
Urinary incontinence and erectile dysfunction are relatively common conditions in the aging male population. Surgical interventions for urinary incontinence include placement of an artificial urinary sphincter (AUS), perineal sling, or sacral nerve stimulator and injections of periurethral bulking agents. Erectile dysfunction can be treated surgically with placement of a penile prosthesis. The complications of these devices can be broadly categorized as device component malposition, malfunction, and infection...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29757013/impact-of-a-behavioral-sleep-intervention-on-new-school-entrants-social-emotional-functioning-and-sleep-a-translational-randomized-trial
#7
Harriet Hiscock, Jon Quach, Kate Paton, Rebecca Peat, Lisa Gold, Sarah Arnup, Kah-Ling Sia, Elizabeth Nicolaou, Melissa Wake
OBJECTIVE/BACKGROUND: Determine the effects and costs of a brief behavioral sleep intervention, previously shown to improve child social-emotional functioning, sleep, and parent mental health, in a translational trial. PARTICIPANTS: Three hundred thirty-four school entrant children from 47 primary schools in Melbourne, Australia, with parent-reported moderate to severe behavioral sleep problems. METHODS: intervention group received sleep hygiene practices and standardized behavioral strategies delivered by trained school nurses in 2013 and 2014...
May 14, 2018: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/29756265/web-based-thyroid-imaging-reporting-and-data-system-malignancy-risk-of-atypia-of-undetermined-significance-or-follicular-lesion-of-undetermined-significance-thyroid-nodules-calculated-by-a-combination-of-ultrasonography-features-and-biopsy-results
#8
Young Jun Choi, Jung Hwan Baek, Jung Hee Shin, Woo Hyun Shim, Seon-Ok Kim, Won-Hong Lee, Dong Eun Song, Tae Yong Kim, Ki-Wook Chung, Jeong Hyun Lee
BACKGROUND: The purpose of this study was to construct a web-based predictive model using ultrasound characteristics and subcategorized biopsy results for thyroid nodules of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) to stratify the risk of malignancy. METHODS: Data included 672 thyroid nodules from 656 patients from a historical cohort. We analyzed ultrasound images of thyroid nodules and biopsy results according to nuclear atypia and architectural atypia...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29753711/chloroplast-phylogeny-of-aa-genome-rice-species
#9
Ali Mohammad Moner, Agnelo Furtado, Robert J Henry
Whole chloroplast genome sequence analysis of 58 wild and domesticated rice samples was used to investigate their phylogeny providing more detail on the biogeography of the major groups of wild A genome rices globally. An optimized chloroplast assembly method was developed and applied to extracting high quality whole chloroplast genome sequences from shot gun whole DNA sequencing data. Forty complete high quality chloroplast genome sequences were assembled (including; temperate japonica, tropical japonica and aus)...
May 10, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29741418/the-effect-of-sio-2-au-core-shell-nanoparticles-on-breast-cancer-cell-s-radiotherapy
#10
Ghazal Darfarin, Roya Salehi, Effat Alizadeh, Behnam Nasiri Motlagh, Abolfazl Akbarzadeh, Alireza Farajollahi
INTRODUCTION: Recently it has been shown that radiation dose enhancement could be achievable in radiotherapy using nanoparticles (NPs). In this study, evaluation was made to determine efficiency of gold-silica shell-core NP in megavoltage irradiation of MCF7 breath cancer cells. MATERIALS AND METHODS: Gold-silicon oxide shell-core NPs were obtained by conjugation of gold NP with amine or thiol functionalized silica NPs (AuN@SiO2 and AuS@SiO2 ). Cellular uptake and cytotoxicity of NPs were examined by fluorescent microscopy and MTT assay, respectively...
May 9, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29739304/soccer-injury-movement-screen-sims-composite-score-is-not-associated-with-injury-among-semi-professional-soccer-players
#11
Robert McCunn, Karen Aus der Fünten, Matthew Whalan, John A Sampson, Tim Meyer
Study Design Prospective cohort. Background The association between movement quality and injury is equivocal. No soccer-specific movement assessment has been prospectively investigated in relation to injury risk. Objectives To investigate the association between a soccer-specific movement quality assessment and injury risk among semi-professional soccer players. Methods Semi-professional soccer players (n=306) from 12 clubs completed the Soccer Injury Movement Screen (SIMS) during the pre-season period. Individual training/match exposure and non-contact time loss injuries were recorded prospectively for the entirety of the 2016 season...
May 8, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29733503/use-of-the-thyroid-imaging-reporting-and-data-system-ti-rads-scoring-system-for-the-evaluation-of-subcentimeter-thyroid-nodules
#12
Vivian L Weiss, Rochelle F Andreotti, Kim A Ely
BACKGROUND: The American Thyroid Association (ATA) recommends fine-needle aspiration (FNA) biopsy of nodules measuring >1.5 cm with low-suspicion sonographic patterns or >1.0 cm with high/intermediate-suspicion features. Routine biopsy of nodules <1 cm is not recommended. However, despite these recommendations, subcentimeter nodules are often referred for FNA biopsy. METHODS: This was a retrospective chart review of consecutive thyroid FNAs during an 18-month period (1157 patients, 1491 nodules, 2016-2017) to evaluate age, sex, medical history, diagnoses, and follow-up...
May 7, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29723435/impact-on-clinical-follow-up-of-the-milan-system-for-salivary-gland-cytology-a-comparison-with-a-traditional-diagnostic-classification
#13
Lester J Layfield, Zubair Baloch, Sharon L Hirschowitz, Esther D Rossi
OBJECTIVE: No universally accepted classification exists for salivary gland fine-needle aspiration (FNA). The proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) offers a uniform classification with management recommendations. We compared FNA diagnoses from a prior study with specific diagnoses with corresponding MSRSGC diagnoses. METHODS: One-hundred and sixty-four cases from a prior cytologic study with histologic follow-up were re-reviewed by one of the authors and assigned to one of the MSRSGC categories...
May 3, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29721677/value-of-abdominal-ultrasound-in-management-of-necrotizing-enterocolitis-a-systematic-review-and-meta-analysis
#14
Maarten Janssen Lok, Hiromu Miyake, Alison Hock, Alan Daneman, Agostino Pierro, Martin Offringa
PURPOSE: Necrotizing enterocolitis (NEC) remains a life-threatening disease among infants in the NICU. Early diagnosis and careful monitoring are essential to improve outcomes. Abdominal ultrasound (AUS) seems a promising addition to current diagnostic modalities, but its clinical utility is uncertain. The aim of this study was to identify AUS features associated with definite NEC (i.e. Bell stage ≥ II), failed medical treatment, surgery, and death. METHODS: Embase, MEDLINE, Web of Science and CINAHL databases were searched for studies that addressed any NEC-related AUS feature in relation to any of the four outcomes...
May 2, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29709433/low-serum-testosterone-is-present-in-nearly-half-of-men-undergoing-artificial-urinary-sphincter-placement
#15
Maxim J McKibben, Jorge Fuentes, Nabeel Shakir, Joceline L Fuchs, Boyd R Viers, Travis Pagliara, Mattias Hofer, Jeremy Scott, Allen F Morey
OBJECTIVES: To report the prevalence of low serum testosterone (LST) in men undergoing AUS placement at a single high-volume institution METHODS: We retrospectively reviewed all men undergoing AUS procedures by a single surgeon from January 2015 to January 2018 to identify men with pretreatment total serum testosterone levels. LST was defined as less than 280 ng/dL. Patients with only post-treatment testosterone levels were excluded. Demographic characteristics and clinical outcomes were compared between men with and without LST...
April 27, 2018: Urology
https://www.readbyqxmd.com/read/29696731/perceived-stress-and-well-being-in-uk-and-australian-dental-hygiene-and-dental-therapy-students
#16
M Harris, J C Wilson, S Hughes, R J M Knevel, D R Radford
INTRODUCTION: This study aimed to explore United Kingdom (UK) and Australian (Aus) dental hygiene and dental therapy students' (DHDTS) perception of stress and well-being during their undergraduate education. Upon qualification, DHDTS in the UK register as dental therapists (DT), and in Australia, they register as Oral Health Therapists (OHT). MATERIALS AND METHODS: A questionnaire was distributed to years 1, 2 and 3 DHDTS at the University of Portsmouth Dental Academy (UPDA) in the UK and La Trobe Rural Health School in Australia...
April 25, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29688851/role-of-genetic-introgression-during-the-evolution-of-cultivated-rice-oryza-sativa-l
#17
Peter Civáň, Terence A Brown
BACKGROUND: Models for the origins of cultivated rice currently fall into two groups: ones that identify independent domestications of the indica, japonica and possibly also the aus types, and others that propose that the domestication phenotype was initially acquired by japonica, the underlying alleles then transferred by introgression to other pre-domesticated populations, giving the indica and aus varieties. Identifying the impact of past gene flow on cultivated rice genomes is therefore crucial to distinguishing between these models and understanding the domestication history of rice...
April 23, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29683529/morphology-combined-with-ancillary-techniques-an-algorithm-approach-for-thyroid-nodules
#18
Esther Diana Rossi, Maurizio Martini, Sara Capodimonti, Tonia Cenci, Mirna Bilotta, Francesco Pierconti, Alfredo Pontecorvi, Celestino Pio Lombardi, Guido Fadda, Luigi Maria Larocca
OBJECTIVE: Several authors have underlined the limits of morphological analysis mostly in the diagnosis of follicular neoplasms (FN). The application of ancillary techniques (AT), including immunocytochemistry(ICC) and molecular testing (MT), contributes to a better definition of the risk of malignancy(ROM) and management of FN. According to literature, the application of models, including the evaluation of ICC, somatic mutations (i.e. BRAFV 600E ), miRNA analysis is proposed for FNs...
April 23, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29680427/daytime-sleepiness-driving-performance-reaction-time-and-inhibitory-control-during-sleep-restriction-therapy-for-chronic-insomnia-disorder
#19
Hannah Whittall, Meg Pillion, Michael Gradisar
BACKGROUND: Sleep restriction therapy (SRT) is a largely untested single treatment component of cognitive-behaviour therapy for insomnia. To date, the evidence for contraindications for SRT is limited to very few studies. The present study investigated the objective and subjective daytime consequences during the acute phase of SRT for adults diagnosed with Chronic Insomnia Disorder. METHODS: Sixteen adults (age = 36.3 ± 13.4 yrs, 12 females, 4 males) underwent SRT for their insomnia over a two week period based on recommendations by Miller and colleagues (2014) [6]...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29680005/the-transobturator-suburethral-sling-a-safe-and-effective-option-for-all-degrees-of-post-prostatectomy-urinary-incontinence
#20
John F Sullivan, Paul N Stassen, Diarmuid Moran, Eva M Bolton, Lisa G Smyth, Cliodhna M Browne, James C Forde, Raanan Tal, Thomas H Lynch
INTRODUCTION: Male stress urinary incontinence (SUI) after radical prostatectomy (RP) is common. The surgical standard of care traditionally has been placement of an artificial urinary sphincter (AUS) but since its introduction the transobturator male sling has been shown to have particular unique advantages. Our aim was to assess outcomes of a consecutive series of suburethral sling insertions in men presenting with all degrees of post RP SUI. MATERIALS AND METHODS: A consecutive cohort of men undergoing AdVance sling insertion following RP were studied...
April 2018: Canadian Journal of Urology
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