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https://www.readbyqxmd.com/read/28300428/empa-s-new-clothes-the-untold-story-of-the-empa-reg-outcome-trial
#1
Aus Alzaid
It is no secret that the diabetes community has been yearning for good news for quite some time. One outstanding issue undermining effective diabetes management has been the lack of demonstrable effects of glycemic interventions on cardiovascular (CV) outcome in people with type 2 diabetes. This, however, seems to have changed recently after the publication of the Empa-Reg Outcome Trial. The study reported an impressive reduction in CV deaths that was observed within weeks of treatment with the diabetes agent, Empagliflozin...
March 16, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28280507/fine-needle-aspiration-of-thyroid-nodules-using-the-bethesda-system-for-reporting-thyroid-cytopathology-an-institutional-experience-in-a-rural-setting
#2
Aili Guo, Yuuki Kaminoh, Terra Forward, Frank L Schwartz, Scott Jenkinson
Background. Fine needle aspiration (FNA) remains the first-line diagnostic in management of thyroid nodules and reduces unnecessary surgeries. However, it is still challenging since cytological results are not always straightforward. This study aimed to examine the results of thyroid FNA using the Bethesda system for reporting thyroid cytopathology (TBSRTC) to establish the level of accuracy of FNA procedures in a rural practice setting. Method. A retrospective chart review was conducted on existing thyroid FNA performed in a referral endocrine center between December 2011 and November 2015...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28268362/pain-detection-from-facial-images-using-unsupervised-feature-learning-approach
#3
Reza Kharghanian, Ali Peiravi, Farshad Moradi
In this paper a new method for continuous pain detection is proposed. One approach to detect the presence of pain is by processing images taken from the face. It has been reported that expression of pain from the face can be detected utilizing Action Units (AUs). In this manner, each action units must be detected separately and then combined together through a linear expression. Also, pain detection can be directly done from a painful face. There are different methods to extract features of both shape and appearance...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263134/standing-cough-test-for-evaluation-of-post-prostatectomy-incontinence-a-pilot-study
#4
Allen F Morey, Nirmish Singla, Maude Carmel, Alexandra Klein, Timothy J Tausch, Jordan Siegel, Isamu Tachibana, Jeremy Scott
INTRODUCTION: We implemented a standardized Standing Cough Test (SCT) for assessment of men with post-prostatectomy incontinence (PPI) and stratified results according to an objective clinical grading scale in an attempt to facilitate male anti-incontinence surgical procedure selection. MATERIALS AND METHODS: SCT was routinely performed during the initial outpatient consultation for PPI. Incontinence severity was recorded based on a novel Male Stress Incontinence Grading Scale (MSIGS) to stratify PPI...
February 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28259878/diagnostic-accuracy-of-fine-needle-aspiration-in-thyroid-nodules-arising-in-patients-with-graves-disease
#5
Jen-Fan Hang, Mohammed T Lilo, Justin A Bishop, Syed Z Ali
OBJECTIVE: Cytopathologic interpretation in Graves disease (GD) is considered challenging due to significant cellular atypia. STUDY DESIGN: We retrospectively identified 55 fine needle aspirations (FNAs) from 43 patients with GD that subsequently underwent thyroidectomy from 1995 to 2016. RESULTS: There were 5 patients with papillary thyroid carcinoma (PTC) and 4 with follicular adenoma (FA). Of the 5 patients with PTC, FNA was interpreted as PTC in 3, atypia of undetermined significance (AUS) in 1, and adenomatoid nodule (AN) in 1 (with a 0...
March 4, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28252867/vernachl%C3%A3-ssigte-klinische-merkmale-der-follikulotropen-mycosis-fungoides-eine-gro%C3%A3-e-klinische-fallserie
#6
Can Baykal, Tugba Atci, Sule Ozturk Sari, Algun Polat Ekinci, Nesimi Buyukbabani
HINTERGRUND UND ZIEL: Als seltene Form der Mycosis fungoides (MF), ist die follikulotrope MF (FMF) durch ein breites Spektrum klinischer Symptome gekennzeichnet. Dazu gehören, neben den vorherrschenden follikulären Läsionen, auch viele atypische Manifestationen. Das Ziel der vorliegenden Studie war eine klinische Bewertung von FMF-Patienten, unter besonderer Berücksichtigung von vernachlässigten dermatologischen Merkmalen. PATIENTEN UND METHODIK: Insgesamt wurden 27 FMF-Patienten aus dem 572 Patienten umfassenden MF-Register unserer Abteilung retrospektiv bezüglich ihrer Demographie sowie der klinischen Merkmale, Behandlungsformen, Nachsorge und Therapieergebnisse bewertet...
March 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28252852/etanercept-adalimumab-und-ustekinumab-bei-psoriasis-analyse-von-209-behandlungsreihen-in-%C3%A3-sterreich
#7
Leo Richter, Igor Vujic, Alma Sesti, Babak Monshi, Martina Sanlorenzo, Christian Posch, Klemens Rappersberger
HINTERGRUND UND ZIELE: Biologika werden häufig zur Behandlung der Psoriasis eingesetzt und wurden in zahlreichen klinischen Studien getestet. Allerdings können sich Wirkungen und Nebenwirkungen (AEs) bei "real-world"-Patienten unterscheiden, da diese keiner solch strengen Auswahl und Überwachung unterzogen werden. Wir haben Therapieadhärenz ("Medikamenten-Überlebenszeit"), Wirksamkeit und AEs (Qualität, Zeitpunkt des Auftretens) bei "real-world"-Psoriasis-Patienten, die mit Etanercept, Adalimumab oder Ustekinumab behandelt wurden, untersucht...
March 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28240591/increased-immunoreactivity-against-human-cytomegalovirus-ul83-in-systemic-sclerosis
#8
Emmanouela Marou, Christos Liaskos, Georgios Efthymiou, Efthymios Dardiotis, Alexandros Daponte, Thomas Scheper, Wolfgang Meyer, Georgios Hadjigeorgiou, Dimitrios P Bogdanos, Lazaros I Sakkas
OBJECTIVES: To study immunoreactivity against human cytomegalovirus (HCMV) in systemic sclerosis (SSc), since HCMV has been put forward as a candidate infectious cause. METHODS: Eighty four patients with SSc (67 females; median age 60 years, range 25-81), 30 patients with multiple sclerosis (MS) (23 females; median age 44, range 20-69 years) and 28 healthy controls (NCs), all pre-tested positive for IgG anti-HCMV antibodies, were studied. IgG anti-UL83 HCMV antibodies were tested by western immunoblotting and expressed in arbitrary units (AUs)...
February 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28226525/pain-detection-from-facial-images-using-unsupervised-feature-learning-approach
#9
Reza Kharghanian, Ali Peiravi, Farshad Moradi, Reza Kharghanian, Ali Peiravi, Farshad Moradi, Ali Peiravi, Reza Kharghanian, Farshad Moradi
In this paper a new method for continuous pain detection is proposed. One approach to detect the presence of pain is by processing images taken from the face. It has been reported that expression of pain from the face can be detected utilizing Action Units (AUs). In this manner, each action units must be detected separately and then combined together through a linear expression. Also, pain detection can be directly done from a painful face. There are different methods to extract features of both shape and appearance...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223197/bethesda-category-iii-iv-and-v-thyroid-nodules-can-nodule-size-help-predict-malignancy
#10
Colleen M Kiernan, Carmen C Solórzano
BACKGROUND: The association of tumor size with malignancy in thyroid nodules with indeterminate cytology (atypia of undetermined significance [AUS]/follicular lesion of undetermined significance [FLUS], suspicious for follicular neoplasm [SFN]/Hürthle cell neoplasm [HCN], and suspicious for malignancy [SM]) has not been clearly studied. STUDY DESIGN: We retrospectively identified 1,104, patients who underwent thyroid FNA and subsequent thyroidectomy. Patients with indeterminate cytology were reviewed...
February 20, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28217980/reproducibility-of-atypia-of-undetermined-significance-follicular-lesion-of-undetermined-significance-category-using-the-bethesda-system-for-reporting-thyroid-cytology-when-reviewing-slides-from-different-institutions-a-study-of-interobserver-variability-among
#11
Vijayalakshmi Padmanabhan, Carrie B Marshall, Guliz Akdas Barkan, Mohiedean Ghofrani, Alice Laser, Idris Tolgay Ocal, Charles David Sturgis, Rhona Souers, Daniel F I Kurtycz
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) offers a six-tiered diagnostic scheme for thyroid Fine Needle Aspiration (FNA): Benign, Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS), suspicious for follicular neoplasm, suspicious for malignancy, malignant, and unsatisfactory with an aim to standardize diagnostic criteria. Reported rate of AUS/FLUS category in the literature has varied from 3% to 20.5%. METHODS: The aim of this study was to assess interobserver variability among cytopathologists to assess reproducibility of the AUS/FLUS category...
February 20, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28217416/the-intra-and-inter-rater-reliability-of-the-soccer-injury-movement-screen-sims
#12
Robert McCunn, Karen Aus der Fünten, Andrew Govus, Ross Julian, Jan Schimpchen, Tim Meyer
BACKGROUND/PURPOSE: The growing volume of movement screening research reveals a belief among practitioners and researchers alike that movement quality may have an association with injury risk. However, existing movement screening tools have not considered the sport-specific movement and injury patterns relevant to soccer. The present study introduces the Soccer Injury Movement Screen (SIMS), which has been designed specifically for use within soccer. Furthermore, the purpose of the present study was to assess the intra- and inter-rater reliability of the SIMS and determine its suitability for use in further research...
February 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28214313/europ%C3%A3-ische-leitlinien-s1-f%C3%A3-r-die-anwendung-von-hochdosierten-intraven%C3%A3-sen-immunglobulinen-in-der-dermatologie
#13
Alexander Enk, Eva Hadaschik, Rüdiger Eming, Gerhard Fierlbeck, Lars French, Giampiero Girolomoni, Michael Hertl, Stephen Jolles, Sarolta Karpati, Kerstin Steinbrink, Georg Stingl, Beatrix Volc-Platzer, Detlef Zillikens
HINTERGRUND UND ZIELE: Die Behandlung schwerer dermatologischer Autoimmunerkrankungen und der toxischen epidermalen Nekrolyse (TEN) mit hochdosierten intravenösen Immunglobulinen (IVIg) ist ein bewährtes therapeutisches Verfahren in der Dermatologie. Da eine IVIg-Therapie in der Regel nur bei seltenen Erkrankungen oder bei schweren Fällen in Betracht gezogen wird, stützt sich die Anwendung von Immunglobulinen zumeist nicht auf Daten aus randomisierten kontrollierten Studien, wie sie in der evidenzbasierten Medizin erforderlich sind...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28214309/wirksamkeit-und-sicherheit-von-fumars%C3%A3-ureestern-in-kombination-mit-phototherapie-bei-patienten-mit-moderater-bis-schwerer-plaque-psoriasis-fast
#14
Peter Weisenseel, Kristian Reich, Wiebke Griemberg, Katharina Merten, Christine Gröschel, Natalie Nunez Gomez, Kirsi Taipale, Beate Bräu, Ina Zschocke
HINTERGRUND: Die Behandlung von Psoriasis-Patienten mit einer Kombination aus Fumarsäureestern (FSE, Fumaderm(®) ) und Phototherapie (UV) ist verbreitet, wurde aber im Rahmen von Studien wenig untersucht. Bisher liegen lediglich Daten aus einer kleinen Pilotstudie vor. Intention dieser Studie war, eine FSE/UV-Kombinationsbehandlung an einem größeren Patientenkollektiv mit mittelschwerer bis schwerer Psoriasis zu untersuchen. PATIENTEN UND METHODIK: In dieser prospektiven, multizentrischen, nichtinterventionellen Studie wurden Daten von Patienten mit FSE/UV-Kombinationstherapie hinsichtlich der Wirksamkeit (PGA' PASI, DLQI, EQ-5D), Sicherheit und Dosierung über einen Zeitraum von zwölf Monaten erfasst und mit Daten einer retrospektiven Studie mit FSE-Monotherapie verglichen...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28201899/the-electric-dipole-moments-in-the-ground-states-of-gold-oxide-auo-and-gold-sulfide-aus
#15
Ruohan Zhang, Yuanqin Yu, Timothy C Steimle, Lan Cheng
The B(2)Σ(-) - X(2)Π3/2(0,0) bands of a cold molecular beam sample of gold monoxide, AuO, and gold monosulfide, AuS, have been recorded at high resolution both field free and in the presence of a static electric field. The observed electric field induced splittings and shifts were analyzed to produce permanent electric dipole moments, μ→el, of 2.94±0.06 D and 2.22±0.05 D for the X(2)Π3/2(v = 0) states of AuO and AuS, respectively. A molecular orbital correlation diagram is used to rationalize the trend in ground state μ→el values for AuX (X = F, Cl, O, and S) molecules...
February 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28197026/artificial-urinary-sphincter-urethral-erosions-temporal-patterns-management-and-incidence-of-preventable-erosions
#16
Deepak K Agarwal, Brian J Linder, Daniel S Elliott
INTRODUCTION: The artificial urinary sphincter (AUS) is the mainstay of surgical treatment for male stress urinary incontinence. Although urethral erosions are a known complication, their temporal distribution and optimal management have not been well characterized. We seek to evaluate the timing, etiologies, and management of urethral erosions in primary AUS implantations. MATERIALS AND METHODS: 1802 male patients underwent AUS procedure at Mayo Clinic (Rochester) from 1983 to 2011, including 1082 primary placements...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28192631/thyroid-cytology-nuclear-versus-architectural-atypia-within-the-atypia-of-undetermined-significance-follicular-lesion-of-undetermined-significance-bethesda-category-have-significantly-different-rates-of-malignancy
#17
Tiffany Rui Xuan Gan, Min En Nga, Jeffrey Huey Yew Lum, Wendy Meihua Wong, Wee Boon Tan, Rajeev Parameswaran, Kee Yuan Ngiam
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology is the most widely used classification system for the reporting of thyroid fine-needle aspiration cytology (FNAC) specimens. However, the "atypical" category ("atypia of undetermined significance" [AUS] or "follicular lesion of undetermined significance" [FLUS]) continues to cause diagnostic and therapeutic dilemmas. The objectives of this study were to describe the differential malignancy rates of FNACs diagnosed as AUS/FLUS based on nuclear or architectural atypia and to assess the significance of demographic and ultrasonographic features in predicting malignancy in this category...
February 13, 2017: Cancer
https://www.readbyqxmd.com/read/28188700/how-suspicious-is-that-nodule-review-of-suspicious-afirma-gene-expression-classifier-in-high-risk-thyroid-nodules
#18
Sudarshana Roychoudhury, Melissa Klein, Fabiola Souza, Cecilia Gimenez, Alice Laser, Rubina Shaheen Cocker, Karen Chau, Kasturi Das
BACKGROUND: The Afirma gene expression classifier (GEC) is being increasingly utilized to confirm the benign nature of indeterminate FNA cytology results thus avoiding unnecessary surgical procedures. However the "suspicious" result of the Afirma GEC does not classify these indeterminate nodules further in determining appropriate management. This study investigated the outcome of the thyroid nodules deemed to be "suspicious" by the Afirma GEC in a high risk population. METHODS: The pathology database was searched for all thyroid nodules with Afirma test results over a three year period, 2013-2015...
April 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28188427/the-prognostic-value-of-right-ventricular-long-axis-strain-in-non-ischaemic-dilated-cardiomyopathies-using-standard-cardiac-magnetic-resonance-imaging
#19
Nisha Arenja, Johannes H Riffel, Manuel Halder, Charly N Djiokou, Thomas Fritz, Florian Andre, Fabian Aus dem Siepen, Thomas Zelniker, Benjamin Meder, Elham Kayvanpour, Grigorios Korosoglou, Hugo A Katus, Sebastian J Buss
OBJECTIVE: To investigate the association of right ventricular long axis strain (RV-LAS), a parameter of longitudinal function, with outcome in patients with non-ischaemic dilated cardiomyopathy (NIDCM). METHODS: In 441 patients with NIDCM, RV-LAS was analysed retrospectively by measuring the length between the epicardial border of the left ventricular apex and the middle of a line connecting the origins of the tricuspidal valve leaflets in end-diastole and end-systole on non-contrast standard cine sequences...
February 10, 2017: European Radiology
https://www.readbyqxmd.com/read/28183663/using-gold-nanostars-modified-pencil-graphite-electrode-as-a-novel-substrate-for-design-a-sensitive-and-selective-dopamine-aptasensor
#20
Rasoul Pourtaghavi Talemi, Seyed Mehdi Mousavi, Hossein Afruzi
For the first time, gold nanostars (GNS) were applied for electrostatic and covalent immobilizing a thiol modified Dopamine aptamer on the pencil graphite electrode and signal amplification. Dopamine aptamer was immobilized on the gold nanostars through electrostatic interaction between negatively charged phosphate groups of aptamer and positively charged gold nanostars and AuS well known covalent interaction. In the presence of Dopamine in the test solution, the charge transfer resistance (RCT) on the electrode surface increased with the increase of the Dopamine concentration due to specific interaction between Dopamine aptamer and Dopamine molecules, which made a barrier for electrons and inhibited the electron-transfer...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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