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Jay Singh, Subhasis Roy, Prasenjit Mukherjee, Debajyoti Konar, Aditya Konar, Sarbani Hazra
AIM: To investigate the incidence of oculocardiac reflex (OCR) with two anesthetic regimens and its prevention using topical anesthetics in a rabbit model, and to explore the effect of topical anesthetics on corneal healing. METHODS: Forty-eight clinically healthy adult New Zealand white rabbits of either sex were divided into two groups (Group A and B) and anesthetized with either ketamine (Group A, n =24) or propofol (Group B, n =24). he incidence of OCR was recorded in each group with a variety of ocular manipulation with or without the use of topical anesthetics (40g/L lignocaine, 5g/L proparacain, 5g/L bupivacaine)...
2010: International Journal of Ophthalmology
Leena Jalota, Vicki Kalira, Elizabeth George, Yung-Ying Shi, Cyrill Hornuss, Oliver Radke, Nathan L Pace, Christian C Apfel
OBJECTIVE: To systematically determine the most efficacious approach for preventing pain on injection of propofol. DESIGN: Systematic review and meta-analysis. DATA SOURCES: PubMed, Embase, Cochrane Library,, and hand searching from the reference lists of identified papers. STUDY SELECTION: Randomised controlled trials comparing drug and non-drug interventions with placebo or another intervention to alleviate pain on injection of propofol in adults...
March 15, 2011: BMJ: British Medical Journal
Yoshitaka Fujii, Masahiro Nakayama
OBJECTIVE: Pain on injection is still a major problem with propofol. Lignocaine (lidocaine) is effective in preventing propofol-induced pain on injection, but cannot entirely control the pain. The purpose of this study was to examine the effect of lignocaine plus ketamine, an N-methyl-D-aspartate receptor antagonist, on pain on injection of propofol. DESIGN: Prospective, randomised, double-blind, placebo-controlled study. SETTING: University Hospital...
2005: Clinical Drug Investigation
D Durham
OBJECTIVE: To review the aetiology and treatment of status epilepticus and present a practical approach to its management. DATA SOURCES: A review of studies reported from 1966 to 1998 and identified through a MEDLINE search of the English-language literature on metabolic and toxic seizures and status epilepticus. SUMMARY OF REVIEW: Status epilepticus describes a condition of prolonged or repetitive seizures and is refractory if it lasts longer than 20-30 minutes despite therapy...
December 1999: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
Jacques Devulder, Erwin Crombez, Eric Mortier
Central pain is a particular form of neuropathic pain. Due to lesions in the spinothalamocortical pathways, ectopic neuronal discharges can occur into different neurons of the spinal cord and brain. Functional MRI, and positron emission tomography might be able to visualize ongoing pain activity which is, sometimes the consequence of spinothalamocortical lesions. Sometimes the patient experiences a burning ice-like sensation. This is more frequent in spinal cord lesions than in brain injuries. Some adrenergic, gabergic neurotransmitters, glycine, prostanoids and glutamate may play a role in pain transmission...
September 2002: Acta Neurologica Belgica
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