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https://www.readbyqxmd.com/read/29775647/exposure-to-imipenem-cilastatin-causes-nephrotoxicity-and-even-urolithiasis-in-wistar-rats
#1
Amal Tahri, Amina Lahyani, Rim Kallel, Fatma Ayadi, Tahia Boudawara, Zouheir Sahnoun
Imipenem/cilastatin is a broad-spectrum β-lactam antibiotic used to treat several bacterial infections. The present study was designed to validate the nephrotoxic effect of this drug in rats and to explore its potentional urolithiatic effect. Thirty two Wistar rats were randomly divided into four groups: three experimental groups treated with different imipenem/cilastatin dosages (30, 50 and 80 mg/kg/day) and a control group.The experimental groups were given intraperitoneal imipenem/cilastatin injections twice daily for 7 days, and the control group was given intraperitoneal vehicle NaCl 0...
May 15, 2018: Toxicology
https://www.readbyqxmd.com/read/29766742/wound-and-sural-nerve-complications-of-the-sinus-tarsi-approach-for-calcaneus-fractures
#2
Shaoliang Li
Background The purpose of this study was to evaluate the optimal timing and measures of the sinus tarsi approach for calcaneus fractures to avoid iatrogenic injury of the sural nerve and to assess for wound complications. METHODS: A case series of 53 patients with calcaneus fractures treated by a single surgeon with the sinus tarsi approach was retrospectively analyzed. On the basis of the delay time from injury to surgery, patients were classified into 4 groups: immediate (0-3 days), early (4-6 days), intermediate (7-14 days), and late (14-18 days)...
May 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29757794/delayed-post-caudal-catheter-placement-pseudomeningocele-a-case-report
#3
Victoria A Bradford, Ricardo J Falcon, Timothy R Petersen, Codruta N Soneru
We present a rare case of a 7-month-old infant who developed a pseudomeningocele 16 days after an uneventful caudal catheter placement. The patient did not exhibit neurological deficits or signs of infection, and the mass increased in size with Valsalva maneuver. Pseudomeningocele, an abnormal collection of cerebrospinal fluid around an opening in the dura mater, can be iatrogenic or traumatic. Regional anesthesia is rarely the cause. Recognizing diagnostic features such as the lack of infectious signs and mass compressibility can prevent misdiagnosis and inappropriate invasive treatment...
May 15, 2018: A&A practice
https://www.readbyqxmd.com/read/29739763/iatrogenic-immunosuppression-may-favour-alternaria-skin-lesion-flares
#4
Rosanna Satta, Maria Pina Dore, Giovanni Mario Pes, Gabriele Biondi
Alternaria spp may cause opportunistic mycoses in the skin after cutaneous inoculation or through blood dissemination in immune-suppressed patients. Here, we describe a case of cutaneous infection with Alternaria spp in a 62-year-old man, presenting with multifocal papules and erythematous nodules involving distal limbs bilaterally. The absence of inflammatory bowel disease was confirmed by a gastroenterologist. The patient was under treatment for uveitis of unknown origin with immunosuppressive doses of cyclosporin and prednisolone for approximately 3 months...
May 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29738302/care-and-treatment-of-a-rare-mycobacterium-avium-complex-infected-wound-a-case-report
#5
Min Wei, Qixia Jiang, Jiandong Wang
An unusual presentation of Mycobacterium avium complex (MAC), unlikely to be encountered in an outpatient dermatology setting, was diagnosed in a patient without an immunodeficiency. A 47-year-old woman, who was immunocompetent and had no risk factors, presented with a full-thickness, infected wound (large amounts of purulent exudate and severe pain) on her back, which had been present for two months. She was diagnosed as having an MAC infection, using a DNA microarray chip method. The patient underwent wound drainage and a fresh silver-containing dressing was applied daily for two months...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29735522/hepcidin-protects-against-lethal-e-coli-sepsis-in-mice-inoculated-with-isolates-from-septic-patients
#6
Deborah Stefanova, Antoan Raychev, Jaime Deville, Romney Humphries, Shelley Campeau, Piotr Ruchala, Elizabeta Nemeth, Tomas Ganz, Yonca Bulut
Iron is an essential micronutrient for most microbes and their hosts. Mammalian hosts respond to infection by inducing the iron-regulatory hormone hepcidin, which causes iron sequestration and a rapid decrease in plasma and extracellular iron concentration (hypoferremia). Previous studies showed that hepcidin regulation of iron is essential for protection from infection-associated mortality with the siderophilic pathogens Yersinia enterocolitica and Vibrio vulnificus However, the evolutionary conservation of the hypoferremic response to infection suggests that not only rare siderophilic bacteria but also common pathogens may be targeted by this mechanism...
May 7, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29733021/axial-torsion-and-infarction-of-meckel-s-diverticulum-in-the-3rd-trimester-of-pregnancy
#7
Radu Botezatu, Radu Marian, Nicolae Gica, George Iancu, Gheorghe Peltecu, Anca Maria Panaitescu
Meckel's diverticulum is a congenital anomaly which can become complicated or remain asymptomatic throughout life. During pregnancy, however, diverticulum infection could become a serious complication. Diverticulum necrosis and perforation are complications that increase morbidity in pregnancy, both maternal and fetal. The rarity of the condition and the maternal physiological changes in pregnancy make the diagnosis difficult. We present the case of a Meckel's diverticulum gangrene in third trimester pregnancy, atypical case due to advanced pregnancy where the risk-benefit balance was carefully evaluated on one hand because of the risk of infection associated with expectant management and on the other hand the risk and complications of iatrogenic preterm premature birth...
March 2018: Chirurgia
https://www.readbyqxmd.com/read/29732218/repair-of-recto-urethral-fistula-with-urethral-augmentation-by-buccal-mucosal-graft-and-gracilis-muscle-flap-interposition-our-experience
#8
Vikram Prabha, Vishal Kadeli
Introduction: Recto-urethral fistula (RUF) is a relatively rare surgical condition, the treatment of which is quite challenging. There are many causes of RUF, but 60% of them are iatrogenic following open prostatectomies, radiotherapy, brachytherapy, urethral instrumentation etc. We present a series of six cases treated at our institution. Material and methods: A retrospective study of all six patients with recto-urethral fistula treated at our centre between 2011 and 2016 was performed...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29730270/management-of-iatrogenic-spinal-cerebrospinal-fluid-leaks-a-cohort-of-124-patients
#9
Royce W Woodroffe, Kirill V Nourski, Logan C Helland, Brian Walsh, Jennifer Noeller, Panagiotis Kerezoudis, Patrick W Hitchon
OBJECTIVES: Cerebrospinal fluid leaks are a frequent complication of spinal surgery, with reported rates between 2 and 20%. Management is highly variable and dependent on comorbidities, complexity of the index procedure, and surgeons' experience. Treatment options include primary or delayed repair, with or without spinal drainage. Using a retrospective cohort, the authors aim to identify the appropriate management of iatrogenic spinal cerebrospinal fluid (CSF) leaks. PATIENTS AND METHODS: We queried our institutional database for postoperative spinal CSF leaks between 1/1/2007 and 3/14/2017 using Current Procedural Terminology (CPT) and International Classification of Disease (ICD) codes...
April 22, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29729120/autoimmune-bullous-diseases-in-non-hiv-kaposi-s-sarcoma-a-retrospective-study-in-a-large-cohort-of-patients
#10
A Tourlaki, G Genovese, E Guanziroli, B M Scoppio, E Berti, L Brambilla
BACKGROUND: Kaposi's sarcoma (KS) is a rare endothelial neoplasm caused by the human herpes virus 8 (HHV-8). Its risk is increased in immunocompromised patients, including those undergoing immunosuppressive therapy for autoimmune bullous diseases. Conversely, HHV-8 infection has been hypothesized to be a triggering factor of bullous diseases, especially pemphigus. Given the fact that both KS and autoimmune bullous diseases have a low incidence in the general population, it could be expected that the association between these disorders would be exceptional...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29725662/management-of-tibioperoneal-trunk-aneurysm-in-a-patient-with-beh%C3%A3-et-disease
#11
Mohammed Hamouda, Hanaa Dakour Aridi, Rachel Elizabeth Lee, Jasninder Singh Dhaliwal, Mahmoud B Malas
Only a few cases of infrapopliteal aneurysms are reported in the literature. These are commonly associated with trauma, infection, and iatrogenic injuries and mostly present as pseudoaneurysms. We report the case of a 44-year-old man with Behçet disease and an 8-cm tibioperoneal trunk aneurysm and discuss the management options of these aneurysms.
March 2018: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29715551/severe-infections-in-critically-ill-solid-organ-transplant-patients
#12
REVIEW
Andre C Kalil, Uriel Sandkovsky, Diana F Florescu
BACKGROUND: Severe infections are among the most common causes of death in immunocompromised patients admitted to the intensive care unit. The epidemiology, diagnosis, and treatment of these infections has evolved in the last decade. AIMS: We aim to provide a comprehensive review of these severe infections in this population. SOURCES: Review of the literature pertaining to severe infections in critically ill solid organ transplant (SOT) patients...
April 28, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29710353/iatrogenic-hepatitis-c-virus-transmission-and-safe-injection-practices
#13
Charles M Defendorf, Sindy Paul, George J Scott
Hepatitis C virus (HCV) infection poses significant adverse health effects. Improper use of vials, needles, syringes, intravenous bags, tubing, and connectors for injections and infusions is a current preventable cause of iatrogenic HCV transmission. Numerous cases have demonstrated the need for continued vigilance and the widespread nature of this iatrogenic infection risk across a variety of medical practice settings in the United States. Failure to implement the evidence-based Centers for Disease Control and Prevention (CDC) infection prevention guidelines exposes patients to preventable harm...
May 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29705917/management-of-hepatic-encephalopathy-not-responsive-to-first-line-treatments
#14
REVIEW
Silvia Nardelli, Lorenzo Ridola, Stefania Gioia, Oliviero Riggio
PURPOSE OF REVIEW: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that occurs in up to 30% of patients with cirrhosis. HE may be a consequence of pure liver failure, as in patients with fulminant hepatitis, or of the combination of liver failure and portal-systemic shunting, as in patients with liver cirrhosis. Episodes of HE are usually related to precipitating events, such as infections or gastrointestinal bleeding; a minority of cirrhotic patients experienced a chronic HE, refractory to standard medical treatment...
April 28, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29698546/the-epidemiology-of-hepatitis-c-in-switzerland-trends-in-notifications-1988-2015
#15
Jean-Luc Richard, Christian Schaetti, Sabine Basler, Mirjam Mäusezahl
With an estimated antibody prevalence of 0.7% in the low-risk population, hepatitis C virus (HCV) endemicity in Switzerland is low. We reviewed data from mandatory hepatitis C surveillance for 1988-2015 in order to describe the evolution of acute HCV infections and newly reported non-acute cases, and their epidemiological features. Crude and stratified annual incidence and notification rates and rate ratios were calculated using Poisson regression. Acute HCV incidence peaked in 2002 at 1.8 cases per 100,000 population, then declined sharply, levelling at around 0...
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29697380/actual-issues-of-odontogenic-maxillary-sinusitis-review
#16
S Grygorov, G Poberezhnik, A Grygorova
Odontogenic maxillary sinusitis has now increasing incidence in dental and otorhynolaryngological practice. Its incidence varies from 10-12 % to 50-75 %, according to different authors. Literature study showed that odontogenic maxillary sinusites are mostly unilateral, and significantly differ in complaints, clinical signs, and diagnostic and treatment measures from other types of sinusitis. This should be taken into account, because often odontogenic maxillary sinusitis is misdiagnosed with common sinusitis, and only in 77 % such patients are examined by both dental specialist and otorhynolaryngologist...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29675625/multidetector-ct-of-iatrogenic-and-self-inflicted-vascular-lesions-and-infections-at-the-groin
#17
REVIEW
Massimo Tonolini, Anna Maria Ierardi, Gianpaolo Carrafiello, Domenico Laganà
The number and complexity of endovascular procedures performed via either arterial or venous access are steadily increasing. Albeit associated with higher morbidity compared to the radial approach, the traditional common femoral artery remains the preferred access site in a variety of cardiac, aortic, oncologic and peripheral vascular procedures. Both transarterial and venous cannulation (for electrophysiology, intravenous laser ablation and central catheterisation) at the groin may result in potentially severe vascular access site complications (VASC)...
April 19, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29670869/pathogenetic-and-prognostic-factors-for-neonatal-gastric-perforation-personal-experience-and-systematic-review-of-the-literature
#18
Chiara Iacusso, Alessandro Boscarelli, Fabio Fusaro, Pietro Bagolan, Francesco Morini
Introduction: Neonatal gastric perforation (NGP) is a rare entity. Our aim was to report our experience and review the recent literature to characterize NGP, describe associated factors, and define prognostic factors. Materials and methods: Retrospective review of all consecutive patients with NGP treated between June 2009 and December 2017 in a third level pediatric hospital. In addition, a systematic review of Medline and Scopus database was performed using a defined strategy...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29666713/comprehensive-treatment-of-severe-periodontal-and-periimplant-bone-destruction-caused-by-iatrogenic-factors
#19
Gregor-Georg Zafiropoulos, Andreas Parashis, Taha Abdullah, Evangelos Sotiropoulos, Gordon John
Dental implant success requires placement after periodontal therapy, with adequate bone volume, plaque control, primary stability, control of risk factors, and use of well-designed prostheses. This report describes the surgical and prosthetic management of a patient with severe iatrogenic periodontal/periimplant bone destruction. Methods. A 55-year-old female smoker with fixed partial dentures (FPDs) supported on teeth and implants presented with oral pain, swelling, bleeding, and a 10-year history of multiple implant placements and implants/prosthesis failures/replacements...
2018: Case Reports in Dentistry
https://www.readbyqxmd.com/read/29659393/unexpected-vesicoureteral-reflux-into-a-nonfunctioning-transplant-kidney-on-renal-scintigraphy
#20
Adam Cruz, Daniel J Wale, Ka Kit Wong, Brett M Arnkoff, Benjamin L Viglianti
Vesicoureteral reflux after renal transplantation is associated with increase risk of urinary tract infections, renal scarring, and graft failure. We describe a case of a 46-year-old woman with 2 transplant kidneys, one functioning and another nonfunctioning, presenting with pelvic pain after a bilateral periureteral bulking procedure. Diuretic renography was performed to exclude iatrogenic ureteral obstruction. This showed a normally functioning transplant kidney without obstruction and subsequent vesicoureteral reflux into the collecting system of the nonfunctioning transplant kidney...
April 13, 2018: Clinical Nuclear Medicine
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