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Chlamydia lung infection

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https://www.readbyqxmd.com/read/29893841/the-p110%C3%AE-isoform-of-phosphatidylinositol-3-kinase-plays-an-important-role-in-host-defense-against-chlamydial-lung-infection-through-influencing-cd4-t-cell-function
#1
Sai Qiao, Ningbo Zheng, Lida Sun, Gaoju Pang, Shuhe Wang, Ping Jia, Jude Ezeh Uzonna, Hong Bai, Xi Yang
PI3Ks display integrant significance in T cell development and differentiation, which is related to host defense against infections. Here, we investigated the role of p110δ isoform of PI3Ks in host defense against chlamydial lung infection in a mouse model. Our data showed that lung infection with Chlamydia muridarum (Cm) activated PI3K/AKT signaling pathway. Compared to WT mice, p110δD910A mice, mice with an inactivating knock-in mutation in the p110δ Isoform of PI3Ks, showed more sever disease phenotype and slower recovery, which was associated with reduced chlamydia specific Th1 and Th17 immune responses following infection...
June 11, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29788053/reversing-ongoing-chronic-intestinal-inflammation-and-fibrosis-by-sustained-block-of-il-12-and-il-23-using-a-vaccine-in-mice
#2
Qingdong Guan, Carolyn R Weiss, Shuhe Wang, Gefei Qing, Xi Yang, Richard J Warrington, Charles N Bernstein, Zhikang Peng
Interleukin (IL)-12 and IL-23 that share subunit p40 are important cytokines in the pathogenesis of inflammatory bowel disease. We reported that mouse p40 peptide-based vaccines ameliorated intestinal inflammation in the prevention of trinitrobenzene sulfonic acid (TNBS)-induced murine colitis model. Here, we evaluated whether administration of the vaccine after establishment of colitis would be effective in modifying both TNBS-induced and dextran sulfate sodium (DSS)-induced chronic colitis and the underlying immune mechanisms...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29719801/an-unusual-presentation-of-a-case-of-human-psittacosis
#3
Yannick Vande Weygaerde, Charlot Versteele, Elke Thijs, Anton De Spiegeleer, Jerina Boelens, Daisy Vanrompay, Eva Van Braeckel, Karim Vermaelen
Background: Chlamydia psittaci is a gram-negative, obligate intracellular organism. Birds are the main reservoir, but also non-avian domestic animals and humans can be infected. In humans it mostly causes respiratory infections due to occupational exposure with varying severity. Sensitive and specific diagnostic tests are needed to define psittacosis in humans as these tests also allow rapid tracing of the animal source. However, diagnosis in humans is often based on time-consuming culture techniques and antibody detection assays as in many countries, the existing molecular diagnostic tests for psittacosis are not reimbursed by the public health insurance...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29670466/v-%C3%AE-4-t-cells-a-novel-il-17-producing-%C3%AE-%C3%AE-t-subsets-during-the-early-phase-of-chlamydial-airway-infection-in-mice
#4
Li-da Sun, Sai Qiao, Yue Wang, Gao-Ju Pang, Xiao-Yu Zha, Teng-Li Liu, Hui-Li Zhao, Ju-You Liang, Ning-Bo Zheng, Lu Tan, Hong Zhang, Hong Bai
Our previous studies showed that γδ T cells provided immune protection against Chlamydial muridarum (Cm), an obligate intracellular strain of chlamydia trachomatis, lung infection by producing abundant IL-17. In this study, we investigated the proliferation and activation of lung γδ T cell subsets, specifically the IL-17 and IFN γ production by them following Cm lung infection. Our results found that five γδ T cell subsets, V γ 1+ T, V γ 2+ T, V γ 4+ T, V γ 5+ T, and V γ 6+ T, expressed in lungs of naïve mice, while Cm lung infection mainly induced the proliferation and activation of V γ 4+ T cells at day 3 p...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29661927/t-independent-ifn%C3%AE-and-b-cells-cooperate-to-prevent-mortality-associated-with-disseminated-chlamydia-muridarum-genital-tract-infection
#5
Taylor B Poston, Catherine M O'Connell, Jenna Girardi, Jeanne E Sullivan, Uma M Nagarajan, Anthony Marinov, Amy M Scurlock, Toni Darville
CD4 T cells and antibody are required for optimal acquired immunity to C. muridarum genital tract infection, and T cell-mediated IFNγ production is necessary to clear infection in the absence of humoral immunity. However, the role of T cell-independent immune responses during primary infection remains unclear. We investigated this question by inoculating wild-type and immune-deficient mice with C. muridarum CM001, a clonal isolate capable of enhanced extragenital replication. Genital inoculation of wild-type mice resulted in transient dissemination to the lungs and spleen that then was rapidly cleared from these organs...
April 16, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29352509/molecular-evidence-to-suggest-pigeon-type-chlamydia-psittaci-in-association-with-an-equine-foal-loss
#6
M Jelocnik, C Jenkins, B O'Rourke, J Barnwell, A Polkinghorne
Chlamydia psittaci is an important avian pathogen with spillover from infected wild and domesticated birds also posing a risk to human health. We recently reported a case of C. psittaci equine placentitis associated with further spillover to humans. Molecular typing of this case revealed it belonged to the 6BC clade of C. psittaci, a globally distributed highly virulent set of strains, typically linked to infection spillover from parrots. Equine chlamydiosis associated with C. psittaci infection has previously been reported elsewhere in countries where parrots are not endemic, however, raising questions over the identity of infecting C...
June 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29281663/circulating-and-broncho-alveolar-interleukin-6-in-relation-to-body-temperature-in-an-experimental-model-of-bovine-chlamydia-psittaci-infection
#7
Annette Prohl, Carola H Ostermann, Christoph D Rummel, Joachim Roth, Petra Reinhold
In rodent models of experimentally induced fever, the important role of interleukin-6 (IL-6) as a circulating endogenous pyrogen is well established. Studies employing larger animal species and real infections are scarce. Therefore, we assessed bioactive IL-6 in peripheral blood and in broncho-alveolar lavage fluid (BALF) of calves after intra-bronchial inoculation with vital Chlamydia psittaci (Cp), with inactivated Cp, or with BGM cells. Only calves inoculated with vital Cp developed fever (peak at 2-3 days after challenge) and significantly increased IL-6 activity...
2017: PloS One
https://www.readbyqxmd.com/read/29217176/a-strong-adjuvant-based-on-glycol-chitosan-coated-lipid-polymer-hybrid-nanoparticles-potentiates-mucosal-immune-responses-against-the-recombinant-chlamydia-trachomatis-fusion-antigen-cth522
#8
Fabrice Rose, Jeanette Erbo Wern, Francesca Gavins, Peter Andersen, Frank Follmann, Camilla Foged
Induction of mucosal immunity with vaccines is attractive for the immunological protection against pathogen entry directly at the site of infection. An example is infection with Chlamydia trachomatis (Ct), which is the most common sexually transmitted infection in the world, and there is an unmet medical need for an effective vaccine. A vaccine against Ct should elicit protective humoral and cell-mediated immune (CMI) responses in the genital tract mucosa. We previously designed an antibody- and CMI-inducing adjuvant based on poly(dl-lactic-co-glycolic acid) (PLGA) nanoparticles modified with the cationic surfactant dimethyldioctadecylammonium bromide and the immunopotentiator trehalose-6,6'-dibehenate...
February 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29191191/asymptomatic-infections-with-highly-polymorphic-chlamydia-suis-are-ubiquitous-in-pigs
#9
Min Li, Martina Jelocnik, Feng Yang, Jianseng Gong, Bernhard Kaltenboeck, Adam Polkinghorne, Zhixin Feng, Yvonne Pannekoek, Nicole Borel, Chunlian Song, Ping Jiang, Jing Li, Jilei Zhang, Yaoyao Wang, Jiawei Wang, Xin Zhou, Chengming Wang
BACKGROUND: Chlamydia suis is an important, globally distributed, highly prevalent and diverse obligate intracellular pathogen infecting pigs. To investigate the prevalence and genetic diversity of C. suis in China, 2,137 nasal, conjunctival, and rectal swabs as well as whole blood and lung samples of pigs were collected in 19 regions from ten provinces of China in this study. RESULTS: We report an overall positivity of 62.4% (1,334/2,137) of C. suis following screening by Chlamydia spp...
December 1, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29070907/co-infection-of-chlamydia-psittaci-with-h9n2-ort-and-aspergillus-fumigatus-contributes-to-severe-pneumonia-and-high-mortality-in-spf-chickens
#10
Jun Chu, Qiang Zhang, Zonghui Zuo, Saeed El-Ashram, Yongxia Guo, Peng Zhao, Shujian Huang, Cheng He, Ahrar Khan
Since 2007, most areas of China have seen outbreaks of poultry airsacculitis, which causes hugely economic losses to the poultry industry. However, there are no effective measures to combat the problem. In this study, 105 rations were collected to isolate Aspergillus spp. from the diseased farms. In subsequent experiments, SPF chickens were inoculated with Ornithobacterium rhinotracheale (ORT), Chlamydia psittaci (C. psittaci) and Aspergillus fumigatus (A. fumigatus), and mortality rate, body weight gain and lesion score were evaluated...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28691023/iron-homeostasis-in-tissues-is-affected-during-persistent-chlamydia-pneumoniae-infection-in-mice
#11
Marie Edvinsson, Jonas Tallkvist, Christina Nyström-Rosander, Nils-Gunnar Ilbäck
Chlamydia pneumoniae (C. pneumoniae) may be a mediator in the pathogenesis of atherosclerosis. For its growth C. pneumoniae depends on iron (Fe), but how Fe changes in tissues during persistent infection or affects bacterial replication in tissues is unknown. C. pneumoniae -infected C57BL/6J mice were sacrificed on days 4, 8, 20, and 40. Mice had bacteria in the lungs and liver on all days. Inflammatory markers, chemokine Cxcl2 and interferon-gamma , were not affected in the liver on day 40. The copper (Cu)/zinc (Zn) ratio in serum, another marker of infection/inflammation, increased on day 4 and tended to increase again on day 40...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28567043/simultaneous-subcutaneous-and-intranasal-administration-of-a-caf01-adjuvanted-chlamydia-vaccine-elicits-elevated-iga-and-protective-th1-th17-responses-in-the-genital-tract
#12
Jeanette Erbo Wern, Maria Rathmann Sorensen, Anja Weinreich Olsen, Peter Andersen, Frank Follmann
The selection of any specific immunization route is critical when defining future vaccine strategies against a genital infection like Chlamydia trachomatis (C.t.). An optimal Chlamydia vaccine needs to elicit mucosal immunity comprising both neutralizing IgA/IgG antibodies and strong Th1/Th17 responses. A strategic tool to modulate this immune profile and mucosal localization of vaccine responses is to combine parenteral and mucosal immunizations routes. In this study, we investigate whether this strategy can be adapted into a two-visit strategy by simultaneous subcutaneous (SC) and nasal immunization...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28526018/infection-mediated-asthma-etiology-mechanisms-and-treatment-options-with-focus-on-chlamydia-pneumoniae-and-macrolides
#13
REVIEW
Wilmore C Webley, David L Hahn
Asthma is a chronic respiratory disease characterized by reversible airway obstruction and airway hyperresponsiveness to non-specific bronchoconstriction agonists as the primary underlying pathophysiology. The worldwide incidence of asthma has increased dramatically in the last 40 years. According to World Health Organization (WHO) estimates, over 300 million children and adults worldwide currently suffer from this incurable disease and 255,000 die from the disease each year. It is now well accepted that asthma is a heterogeneous syndrome and many clinical subtypes have been described...
May 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28400772/sphingolipids-are-dual-specific-drug-targets-for-the-management-of-pulmonary-infections-perspective
#14
REVIEW
Lalita Sharma, Hridayesh Prakash
Sphingolipids are the major constituent of the mucus secreted by the cells of epithelial linings of lungs where they maintain the barrier functions and prevent microbial invasion. Sphingolipids are interconvertible, and their primary and secondary metabolites have both structural and functional roles. Out of several sphingolipid metabolites, sphingosine-1 phosphate (S1P) and ceramide are central molecules and decisive for sphingolipid signaling. These are produced by enzymatic activity of sphingosine kinase-1 (SK-1) upon the challenge with either biological or physiological stresses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28385608/comparison-of-the-nine-polymorphic-membrane-proteins-of-chlamydia-trachomatis-for-their-ability-to-induce-protective-immune-responses-in-mice-against-a-c-muridarum-challenge
#15
Sukumar Pal, Alison Favaroni, Delia F Tifrea, Philipp T Hanisch, Sören E T Luczak, Johannes H Hegemann, Luis M de la Maza
OBJECTIVES: To test vaccines, formulated with novel antigens, to protect mice against Chlamydia infections. METHODS: To determine the ability of polymorphic membrane proteins (Pmps) to induce cross-species protective immune responses, recombinant fragments from all nine C. trachomatis serovar E Pmps were used to vaccinate BALB/c mice utilizing CpG-1826 and Montanide ISA 720 as adjuvants. C. muridarum recombinant MOMP and PBS, formulated with the same adjuvants, were used as positive and negative controls, respectively...
May 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28264910/expanding-role-of-type-ii-secretion-in-bacterial-pathogenesis-and-beyond
#16
REVIEW
Nicholas P Cianciotto, Richard C White
Type II secretion (T2S) is one means by which Gram-negative pathogens secrete proteins into the extracellular milieu and/or host organisms. Based upon recent genome sequencing, it is clear that T2S is largely restricted to the Proteobacteria , occurring in many, but not all, genera in the Alphaproteobacteria , Betaproteobacteria , Gammaproteobacteria , and Deltaproteobacteria classes. Prominent human and/or animal pathogens that express a T2S system(s) include Acinetobacter baumannii , Burkholderia pseudomallei , Chlamydia trachomatis , Escherichia coli , Klebsiella pneumoniae , Legionella pneumophila , Pseudomonas aeruginosa , Stenotrophomonas maltophilia , Vibrio cholerae , and Yersinia enterocolitica T2S-expressing plant pathogens include Dickeya dadantii , Erwinia amylovora , Pectobacterium carotovorum , Ralstonia solanacearum , Xanthomonas campestris , Xanthomonas oryzae , and Xylella fastidiosa T2S also occurs in nonpathogenic bacteria, facilitating symbioses, among other things...
May 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28194020/cd103-lung-dendritic-cells-ldcs-induce-stronger-th1-th17-immunity-to-a-bacterial-lung-infection-than-cd11b-hi-ldcs
#17
Sudhanshu Shekhar, Ying Peng, Shuhe Wang, Xi Yang
Recent studies suggest differential roles for CD103+ and CD11b(hi) lung dendritic cells (LDCs) in host defense against viral and bacterial infections. In this study, we examined the contribution of these LDC subsets in protective immunity to chlamydial lung infection using a Chlamydia muridarum mouse infection model. We found that CD103+ LDCs showed higher expression of costimulatory molecules (CD40, CD80 and CD86) and increased production of cytokines (IL-12p70, IL-10, IL-23 and IL-6) compared with CD11b(hi) LDCs, but the expression of programmed death-ligand 1 (PD-L1) was similar between the two subsets...
February 13, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/27892938/dendritic-cell-function-and-pathogen-specific-t-cell-immunity-are-inhibited-in-mice-administered-levonorgestrel-prior-to-intranasal-chlamydia-trachomatis-infection
#18
Nirk E Quispe Calla, Rodolfo D Vicetti Miguel, Ao Mei, Shumin Fan, Jocelyn R Gilmore, Thomas L Cherpes
The growing popularity of levonorgestrel (LNG)-releasing intra-uterine systems for long-acting reversible contraception provides strong impetus to define immunomodulatory properties of this exogenous progestin. In initial in vitro studies herein, we found LNG significantly impaired activation of human dendritic cell (DCs) and their capacity to promote allogeneic T cell proliferation. In follow-up studies in a murine model of intranasal Chlamydia trachomatis infection, we analogously found that LNG treatment prior to infection dramatically reduced CD40 expression in DCs isolated from draining lymph nodes at 2 days post infection (dpi)...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27796286/respective-il-17a-production-by-%C3%AE-%C3%AE-t-and-th17-cells-and-its-implication-in-host-defense-against-chlamydial-lung-infection
#19
Hong Bai, Xiaoling Gao, Lei Zhao, Ying Peng, Jie Yang, Sai Qiao, Huili Zhao, Shuhe Wang, YiJun Fan, Antony George Joyee, Zhi Yao, Xi Yang
The role of IL-17A is important in protection against lung infection with Chlamydiae, an obligate intracellular bacterial pathogen. In this study, we explored the producers of IL-17A in chlamydial lung infection and specifically tested the role of major IL-17A producers in protective immunity. We found that γδT cells and Th17 cells are the major producers of IL-17A at the early and later stages of chlamydial infection, respectively. Depletion of γδT cells in vivo at the early postinfection (p.i.) stage, when most γδT cells produce IL-17A, failed to alter Th1 responses and bacterial clearance...
October 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/27725282/deficiency-of-light-signaling-pathway-exacerbates-chlamydia-psittaci-respiratory-tract-infection-in-mice
#20
Hengling Cai, Shenghua Chen, Sha Xu, Yuanbin Sun, Qinqin Bai, Chunxue Lu, Yuyu Chen, Xizong Fu, Guilian Xu, Lili Chen
LIGHT, a costimulatory member of the immunoglobulin superfamily (Ig SF), can greatly impact T cell activation. The role of the LIGHT signaling pathway in chlamydial infection was evaluated in mice following respiratory tract infection with Chlamydia psittaci. Compared with wild type (WT) mice, LIGHT knockout (KO) mice showed significant reduction of body weight, much lower survival rate, higher bacterial burden, prolonged infection time courses and more severe pathological changes in lung tissue. The mRNA levels of IFN-γ, TNF-α, IL-17 and IL-12 in the lung tissue of LIGHT KO mice were significantly lower than those in WT mice...
November 2016: Microbial Pathogenesis
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