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T-prolymphocytic leukemia

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https://www.readbyqxmd.com/read/27851580/1946-a-rare-case-of-t-cell-prolymphocytic-leukemia
#1
Chhaya Patel, Angela Birdwell, Badri Giri, Shekhar Ghamande
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27757215/brentuximab-vedotin-therapy-for-cutaneous-lesions-in-t-prolymphocytic-leukemia-a-case-report
#2
Jordan Senchak, Peter Pickens
We present an 88-year-old male with simultaneous T-cell prolymphocytic leukemia and stable smoldering myeloma with excellent initial response to three months of alemtuzumab. The patient relapsed at twelve months with severe cutaneous disease. Biopsy of a representative plaque demonstrated CD30 positivity in rare malignant lymphocytes. The patient demonstrated no response to reintroduction with a full course of alemtuzumab. He was therefore treated with brentuximab vedotin, resulting in partial remission of skin involvement that persisted for three months...
September 28, 2016: Hematology Reports
https://www.readbyqxmd.com/read/27736276/intraocular-t-cell-prolymphocytic-leukemia-masquerading-as-necrotizing-herpetic-retinitis
#3
Nikolaos Krassas, Guillermo de la Mata Perez, Nicholas Jones
No abstract text is available yet for this article.
October 13, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27719728/-a-case-report-of-t-cell-prolymphocytic-leukemia-complicated-with-budd-chiari-syndrome-and-literature-review
#4
L Huang, H X Yao, C M Wu
No abstract text is available yet for this article.
September 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/27516534/cutaneous-histoplasmosis-with-prominent-parasitization-of-epidermal-keratinocytes-report-of-a-case
#5
Hedieh H Honarpisheh, Jonathan L Curry, Kristen Richards, Priyadharsini Nagarajan, Phyu P Aung, Carlos A Torres-Cabala, Doina Ivan, Carol R Drucker, Richard Cartun, Victor G Prieto, Michael T Tetzlaff
Disseminated histoplasmosis most commonly occurs in immunosuppressed individuals and involves the skin in approximately 6% of patients. Cutaneous histoplasmosis with an intraepithelial-predominant distribution has not been described. A 47-year-old man was admitted to our institution with fever and vancomycin-resistant enterococcal bacteremia. He had been diagnosed with T-cell prolymphocytic leukemia 4 years earlier and had undergone matched-unrelated-donor stem cell transplant 2 years earlier; on admission, he had relapsed disease...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27504481/bullous-leukemia-cutis-in-a-patient-with-t-cell-prolymphocytic-leukemia
#6
Sarah Y Siu, Qiujie Jiang, Onder Alpdogan, Ashley Gochoco, Jerald Gong, Jason B Lee, Joya Sahu
No abstract text is available yet for this article.
July 2016: JAAD Case Reports
https://www.readbyqxmd.com/read/27123263/immunoglobulin-gene-translocations-in-chronic-lymphocytic-leukemia-a-report-of-35-patients-and-review-of-the-literature
#7
Marc DE Braekeleer, Corine Tous, Nadia Guéganic, Marie-Josée LE Bris, Audrey Basinko, Frédéric Morel, Nathalie Douet-Guilbert
Chronic lymphocytic leukemia (CLL) represents the most common hematological malignancy in Western countries, with a highly heterogeneous clinical course and prognosis. Translocations involving the immunoglobulin (IG) genes are regularly identified. From 2000 to 2014, we identified an IG gene translocation in 18 of the 396 patients investigated at diagnosis (4.6%) and in 17 of the 275 analyzed during follow-up (6.2%). A total of 4 patients in whom the IG translocation was identified at follow-up did not carry the translocation at diagnosis...
May 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27047646/t-cell-natural-killer-cell-neoplasms-presenting-as-leukemia-case-series-from-single-tertiary-care-center
#8
Shano Naseem, Maninderbir Kaur, Manupdesh Singh Sachdeva, Jasmina Ahluwalia, Reena Das, Neelam Varma, Subhash Varma
BACKGROUND: Mature T/ NK-cell neoplasms are a rare group of disorders and their presentation as leukemia is even rarer. Most of the previous studies have focused on mature B-cell lineage leukemias and there is a paucity of data on mature T/NK-cell lineage leukemias. We, therefore, planned this study to analyze their spectrum, frequency, morphology and immunophenotypic features. SUBJECTS AND METHODS: All cases of lymphomas presenting as leukemia over a period of two and a half years were evaluated...
January 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27043335/rosacea-like-leukemia-cutis-a-case-report
#9
Mariana Cruz Manzano, Lilliana Ramírez García, Julio E Sánchez Pont, Ana I Velázquez Mañana, Jorge L Sánchez
Leukemia cutis describes the infiltration and dissemination of neoplastic leukemic cells into the epidermis, dermis, or subcutis, resulting in clinically identifiable cutaneous lesions. Depending on the type of leukemia, a wide range of clinical and histopathological findings may be encountered. This report describes a patient with a rosacea-like eruption as a unique clinical presentation of T-cell prolymphocytic leukemia.
August 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26998991/-cerebriform-variant-type-of-t-cell-prolymphocytic-leukemia-report-of-one-case
#10
Camila Peña, Ximena Valladares, Carolina Soto, Andrea Encina, Neda Marinov, María Soledad Undurraga, María Elena Cabrera
T cell Prolymphocytic Leukemia (T-PLL) is a rare and aggressive mature T cell Lymphocyte Leukemia. Twenty five percent of cases present as a small cell variant, and only 5% as a cerebriform variant. We report a 58 year-old man with rapidly progressive severe leukocytosis, skin lesions, lymphadenopathy, hepatosplenomegaly and pleural effusion. The lymphocytes had a cerebriform type. The diagnosis of T-PLL variant was made by morphology and immunophenotype study of peripheral blood. Karyotype was found to be complex...
January 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/26955661/an-extremely-indolent-t-cell-leukemia-an-18-year-follow-up
#11
Samuel Adediran, Dennis Cornfield, Adam Bagg, Nicole Agostino
T-cell prolymphocytic leukemia (T-PLL) is a rare malignancy that comprises about 2% of all mature lymphoid neoplasms. Patients usually present with prominent peripheral blood lymphocytosis, splenomegaly, hepatomegaly, lymphadenopathy, B symptoms, and occasionally with skin lesions.¹ The disease follows an aggressive clinical course with rapid progression and typically has a median survival of less than 1 year. In some cases, the disease is indolent for a period of time before becoming aggressive.² In 2002, 7 years after initial diagnosis in 1995, the case discussed herein was reported as a rare, indolent form of T-PLL...
February 2016: Journal of Community and Supportive Oncology
https://www.readbyqxmd.com/read/26916070/the-clinical-significance-of-8q24-myc-rearrangement-in-chronic-lymphocytic-leukemia
#12
Yan Li, Shimin Hu, Sa A Wang, Shaoying Li, Yang O Huh, Zhenya Tang, L Jeffrey Medeiros, Guilin Tang
Chromosome 8q24/MYC rearrangement is associated with Burkitt lymphoma and some aggressive B-cell lymphomas, but is rare in chronic lymphocytic leukemia. We here report a cohort of 20 chronic lymphocytic leukemia patients with 8q24/MYC rearrangement, 3 detected at time of initial diagnosis and 17 acquired after a median interval of 48 months. At the time when 8q24/MYC arrangement was detected, 18 patients had B-symptoms, 17 had lymphadenopathy, and 17 had splenomegaly. Histologically, typical chronic lymphocytic leukemia morphology was seen in six patients, increased prolymphocytes in nine and Richter's transformation in five patients...
May 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/26813734/small-cell-variant-of-t-cell-prolymphocytic-leukemia-with-acquired-palmoplantar-keratoderma-and-cutaneous-infiltration
#13
Buthaina Al-Musalhi, Nancy Shehata, Robin Billick
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive post-thymic malignancy that is characterized by the proliferation of small- to medium- sized prolymphocytes. The classic clinical features of T-PLL are lymphocytosis, lymphadenopathy, hepatosplenomegaly, and skin lesions. Skin involvement varies clinically from diffuse infiltrated erythema. Infiltration is localized to the face and ears, nodules, and erythroderma. We present a case of small cell variant of T-PLL in a patient who presented with unusual cutaneous manifestations of acquired palmoplantar keratoderma (PPK) followed by diffuse erythematous infiltrated papules and plaques involving the trunk...
January 2016: Oman Medical Journal
https://www.readbyqxmd.com/read/26802532/combination-epigenetic-and-immunotherapy-overcomes-resistance-to-monoclonal-antibodies-in-hematologic-malignancies-a-new-therapeutic-approach
#14
REVIEW
Elliot M Epner, Bikramajit Singh Saroya, Zainul S Hasanali, Thomas P Loughran
We recently reported that addition of epigenetic agents could overcome resistance of leukemic cells to monoclonal antibody-mediated anti-tumor effects in T-cell prolymphocytic leukemia. We also reported that epigenetic agents could induce expression of the CD30 gene, thus providing a therapeutic target for the antibody drug conjugate brentuximab vedotin. Here we discuss these findings and their generality to treatment of other hematologic and solid malignancies.
March 2016: Experimental Hematology
https://www.readbyqxmd.com/read/26379148/expression-of-s100-protein-in-cd4-positive-t-cell-lymphomas-is-often-associated-with-t-cell-prolymphocytic-leukemia
#15
Nidhi Aggarwal, Tawatchai Pongpruttipan, Snehal Patel, Michael G Bayerl, Serhan Alkan, Bharat Nathwani, Urvashi Surti, Sumire Kitahara, Yingyong Chinthammitr, Steven H Swerdlow
S100 T-cell lymphomas are infrequent, and except 1 all have been CD4 negative. On the basis of an index case of CD4 S100 T-cell prolymphocytic leukemia (T-PLL), we studied S100 protein expression in 19 additional T-PLLs and 56 other T-cell lymphomas that are usually CD4, including 15 angioimmunoblastic T-cell lymphomas, 24 anaplastic large cell lymphomas (16 ALK and 8 ALK), 7 mycosis fungoides/Sézary syndrome, and 10 peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS). Two additional S100 CD4 PTCL, NOS cases were also reviewed...
December 2015: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26299583/encephalitozoon-hellem-in-a-patient-with-cd4-t-cell-prolymphocytic-leukemia-case-report-and-genomic-identification
#16
Gilles Nevez, Solène Le Gal, Dorothée Quinio, Jean-Christophe Ianotto, Christian Berthou, Samia Hamane, Claudine Sarfati, Jean Menotti
Five cases of microsporidioses among leukemic patients, 4 in myeloid-leukemic patients and 1 in a chronic lymphocytic leukemia, have been described until now. We report a case of microsporidiosis and the genomic identification of Encephalitozoon hellem in a patient with CD4(+) T-cell prolymphocytic leukemia.
November 2015: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/26293613/t-cell-prolymphocytic-leukemia-survival-improves-with-alemtuzemab-but-stem-cell-transplant-eligibility-counts-even-more
#17
COMMENT
Estella Matutes, Aaron Polliack
No abstract text is available yet for this article.
2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/26292711/survival-trends-in-t-cell-prolymphocytic-leukemia-a-seer-database-analysis
#18
LETTER
Rekha Chandran, S K Gardiner, T S Fenske, E S Spurgeon
No abstract text is available yet for this article.
2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/26170393/epigenetic-drugs-reverse-leukemia-resistance
#19
(no author information available yet)
No abstract text is available yet for this article.
September 2015: Cancer Discovery
https://www.readbyqxmd.com/read/26134026/-t-cell-prolymphocytic-leukemia-treated-with-alemtuzumab-and-followed-by-autologous-hematopoietic-stem-cell-transplantation-a-case-report
#20
Meng Chen, Li Zhang, Yongqian Jia, Fang Liu, Jian Li, Danfeng Zhang, Luyang Zhang, Ling Pan
No abstract text is available yet for this article.
June 2015: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
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