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https://www.readbyqxmd.com/read/28230788/the-adverse-effects-of-triptolide-on-the-reproductive-system-of-caenorhabditis-elegans-oogenesis-impairment-and-decreased-oocyte-quality
#1
Qinli Ruan, Yun Xu, Rui Xu, Jiaying Wang, Yongqing Hua, Meng Wang, Jinao Duan
Previous studies have revealed that Triptolide damages female reproductive capacity, but the mechanism is unclear. In this study, we used Caenorhabditis elegans to investigate the effects of Triptolide on the germline and explore its possible mechanisms. Our data show that exposure for 4 h to 50 and 100 mg/L Triptolide reduced C. elegans fertility, led to depletion and inactivation of spermatids with the changes in the expression levels of related genes, and increased the number of unfertilized oocytes through damaging chromosomes and DNA damage repair mechanisms...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28222834/acute-and-chronic-outcomes-of-gas-bubble-disease-in-a-colony-of-african-clawed-frogs-xenopus-laevis
#2
Julia Y Tsai, Stephen A Felt, Donna M Bouley, Sherril L Green
Gas-bubble disease occurs in aquatic species that are exposed to water that is supersaturated with gases. In February 2007, municipal water supersaturated with gas was inadvertently pumped into the vivarium's aquatic housing systems and affected approximately 450 adult female Xenopus laevis. The inflow of supersaturated water was stopped immediately, the holding tanks aggressively aerated, and all experimental manipulations and feeding ceased. Within the first 6 h after the event, morbidity approached 90%, and mortality reached 3...
February 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28215679/causes-of-declining-fertility-in-dairy-cows-during-the-warm-season
#3
REVIEW
F De Rensis, F Lopez-Gatius, I García-Ispierto, G Morini, R J Scaramuzzi
In the Northern Hemisphere, from June to September and in the Southern Hemisphere from December to March, there are periods of reduced fertility (sub-fertility) in dairy cows that are described as summer infertility. Several factors contribute to sub-fertility during this time, such as ambient temperature, humidity and photoperiod. During the warm season there is a reduction in feed intake that may compromise the energy balance of the cow and/or induce an imbalance in the activity of the hypothalamo-hypophyseal-ovarian axis...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28215678/the-impact-of-ovarian-stimulation-protocol-on-oocyte-quality-subsequent-in%C3%A2-vitro-embryo-development-and-pregnancy-after-transfer-to-recipients-in-eld-s-deer-rucervus-eldii-thamin
#4
Ampika Thongphakdee, Debra K Berg, Theerawat Tharasanit, Nikorn Thongtip, Wanlaya Tipkantha, Chainarong Punkong, Daraka Tongthainan, Sakhon Noimoon, Umaporn Maikeaw, Nudthakamol Kajornklin, Boripat Siriaroonrat, Pierre Comizzoli, Sumate Kamolnorranath
Propagating genetically valuable individuals through oocyte collection, in vitro fertilization (IVF) and embryo transfer is critical to maintain sustainable populations of the endangered Eld's deer. The objectives of this study were to assess the impact of exogenous FSH injections on (1) the number and in vitro competence of oocytes collected and (2) the developmental potential of resulting IVF embryos after transfer into recipients during the breeding season (February-April). In a pilot experiment, estrus synchronization was conducted in three surplus females (using intravaginal progesterone-releasing devices, CIDRG for 14 days and injections of buserelin (a GnRH agonist)...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28215677/pyridoxine-supplementation-during-oocyte-maturation-improves-the-development-and-quality-of-bovine-preimplantation-embryos
#5
Mansour Aboelenain, Ahmed Zaky Balboula, Manabu Kawahara, Abd El-Monem Montaser, Samy Moawad Zaabel, Sung-Woo Kim, Masashi Nagano, Masashi Takahashi
Recently, inhibition of cathepsin B (CTSB) activity during in vitro maturation (IVM) and culture (IVC) improved the developmental competence and quality of bovine oocytes and embryos. E-64 is a widely used inhibitor to inhibit CTSB activity, however, E-64 inhibits not only CTSB activity but also the activities of other proteases including cathepsin L (CTSL), papain, calpain, and trypsin. Pyridoxine, the catalytically active form of vitamin B6, plays a crucial role in several cellular processes and has the ability to inhibit CTSB activity...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28206974/caffeine-delays-oocyte-aging-and-maintains-the-quality-of-aged-oocytes-safely-in-mouse
#6
Xia Zhang, Xiaoyan Liu, Li Chen, Dan-Ya Wu, Zheng-Wen Nie, Ying-Ying Gao, Yi-Liang Miao
Caffeine, as an oocyte aging inhibitor, was used in many different species to control or delay oocyte aging. However, the safety of caffeine and developmental competence of aged oocytes inhibited by caffeine has not been studied systematically. So we detected the spindle morphology, distribution of cortical granules, zona pellucida hardening and pronucleus formation to assess oocyte quality of caffeine treated oocytes. We found that aged oocytes treated by caffeine maintained weak susceptibility to activating stimuli and regained normal competent after aged further 6 hr...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28198569/effect-of-eicosapentaenoic-acid-on-bovine-cumulus-oocyte-complex-in-vitro
#7
Noelia Nikoloff, Ana M Pascua, Juan M Anchordoquy, Juan P Anchordoquy, Matías A Sirini, Analia Seoane, Cecilia C Furnus
The aim of the present study was to investigate the effects of eicosapentaenoic acid (EPA) supplementation during in vitro maturation (IVM) of bovine oocytes. The concentrations tested in all experiments were 1 nM, 1 μM and 1 mM EPA. The effect of EPA was evaluated on cumulus-oocyte complexes (COC) by oocyte maturation [cumulus expansion area and oocyte nuclear maturation], genotoxicity [single cell gel electrophoresis (SCGE)] and cytotoxicity [apoptosis, viability and MTT assays] end points. The maturation parameters were affected by exposure of COC to different EPA concentrations in the IVM medium...
February 15, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28197932/effect-of-gnrha-ovulation-trigger-dose-on-follicular-fluid-characteristics-and-granulosa-cell-gene-expression-profiles
#8
Thi Ngoc Lan Vuong, M T Ho, T Q Ha, M Brehm Jensen, C Yding Andersen, P Humaidan
PURPOSE: A recent dose-finding study showed no significant differences in number of mature oocytes, embryos and top-quality embryos when triptorelin doses of 0.2, 0.3 or 0.4 mg were used to trigger final oocyte maturation in oocyte donors co-treated with a gonadotropin-releasing hormone (GnRH) antagonist. This analysis investigated whether triptorelin dosing for triggering final oocyte maturation in oocyte donors induced differences in follicular fluid (FF) hormone levels and granulosa cell gene expression...
February 14, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28188844/infertility-and-ovarian-follicle-reserve-depletion-are-associated-with-dysregulation-of-the-fsh-and-lh-receptor-density-in-human-antral-follicles
#9
Sheena L P Regan, Phil G Knight, John L Yovich, James D Stanger, Yee Leung, Frank Arfuso, Arun Dharmarajan, Ghanim Almahbobi
The low take-home baby rate in older women in Australia (5.8%) undergoing IVF is linked to the depletion of the ovarian reserve of primordial follicles. Oocyte depletion causes an irreversible change to ovarian function. We found that the young patient FSH receptor and LH receptor expression profile on the granulosa cells collected from different size follicles were similar to the expression profile reported in natural cycles in women and sheep. This was reversed in the older patients with poor ovarian reserve...
February 7, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28188594/extracellular-micrornas-in-follicular-fluid-and-their-potential-association-with-oocyte-fertilization-and-embryo-quality-an-exploratory-study
#10
Ronit Machtinger, Rodosthenis S Rodosthenous, Michal Adir, Abdallah Mansour, Catherine Racowsky, Andrea A Baccarelli, Russ Hauser
PURPOSE: The purpose of this study is to determine the profile of extracellular microRNAs (exmiRNAs) in follicular fluid (FF) and explore their association with fertilization potential and embryo quality. METHODS: We collected FF from single follicles containing mature oocytes from 40 women undergoing IVF and we screened for the expression of 754 exmiRNAs in FF using the TaqMan OpenArray® qPCR platform. To determine the association of exmiRNAs and IVF outcomes, we compared their expression levels in FF samples that differ by fertilization status (normally, abnormally, and failed to fertilize) and embryo quality (top vs...
February 10, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28185121/the-association-between-coenzyme-q10-concentrations-in-follicular-fluid-with-embryo-morphokinetics-and-pregnancy-rate-in-assisted-reproductive-techniques
#11
Süleyman Akarsu, Funda Gode, Ahmet Zeki Isik, Zeliha Günnur Dikmen, Mustafa Agah Tekindağ
PURPOSE: This study seeks to evaluate the association between follicular fluid (FF) coenzyme Q10 (CoQ10) levels, embryo morphokinetics, and pregnancy rate. METHODS: Sixty infertile patients who underwent intracytoplasmic sperm injection (ICSI) cycles were included in the study. For each patient, CoQ10 level of the follicular fluid was measured by high-performance liquid chromatography system. After the ICSI of each oocyte, the relationship between the level of CoQ10 content of each follicular fluid, the subsequent embryo quality, and embryo morphokinetics was investigated...
February 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28178360/melatonin-protects-oocyte-quality-from-bisphenol-a-induced-deterioration-in-the-mouse
#12
Mianqun Zhang, Xiaoxin Dai, Yajuan Lu, Yilong Miao, Changyin Zhou, Zhaokang Cui, Honglin Liu, Bo Xiong
BPA (Bisphenol A) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocyte meiotic maturation and fertilization ability. We find that oral administration of BPA (100 μg/kg body weight per day for 7 days) compromises the first polar body extrusion (78.0% VS 57.0%, p < 0...
February 8, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28173052/compromised-oocyte-quality-and-assisted-reproduction-contribute-to-sex-specific-effects-on-offspring-outcomes-and-epigenetic-patterning
#13
Laura Whidden, Josée Martel, Sophia Rahimi, J Richard Chaillet, Donovan Chan, Jacquetta M Trasler
No abstract text is available yet for this article.
November 1, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28170286/effects-of-alcohol-on-mitochondrial-functions-of-cumulus-cells-in-mice
#14
Wanlu Xu, Lihui Huo, Jingjing Li, Chunli Xu, Shuang Wang, Yanhong Yang, Chuang Liu, Xiaomin Zheng, Xiuliang Feng, Xingrong Yan
Alcohol is an important compound used in food, agriculture, and medicine. In this study, we investigated the effect of alcohol on oocyte quality in mice by exposing animals for different duration times during an estrous cycle. Cumulus-oocyte complexes were collected from mice after pregnant mare serum gonadotropin- and human chorionic gonadotropin-induced superovulation. Ovulation number, E2 level in serum, and parthenogenetic embryo development in vitro were evaluated. Mitochondrial gene expression, mitochondrial membrane potential, and reactive oxygen species (ROS) levels in the cumulus were also assessed...
February 7, 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28169189/ovarian-stimulation-protocols-for-ivf-is-more-better-than-less
#15
REVIEW
Michael M Alper, Bart C Fauser
Conventional ovarian stimulation protocols for IVF are designed to achieve maximum oocyte yields. Conventional protocols, however, are associated with patient discomfort, increased risk of ovarian hyperstimulation syndrome and higher costs. In recent years, mild stimulation protocols have risen in popularity. These protocols typically use lower doses (≤150 IU/day), shorter duration of exogenous gonadotrophins, or both, compared with conventional protocols, with the goal of limiting the number of retrieved oocytes to less than eight...
January 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28166979/peroxisome-proliferator-activated-receptor-%C3%AE-improves-porcine-blastocyst-hatching-via-the-regulation-of-fatty-acid-oxidation
#16
Jing Guo, Wen-Fa Lu, Shuang Liang, Jeong-Woo Choi, Nam-Hyung Kim, Xiang-Shun Cui
Peroxisome proliferator-activated receptor δ (Pparδ) is a nuclear receptor that plays critical roles in lipid metabolism, glucose metabolism, and cell growth and differentiation. Several recent studies have shown that Pparδ promotes blastocyst hatching in vitro. However, the mechanism by which it promotes preimplantation embryonic development in vitro remains unclear. In this study, oocytes and parthenotes were treated with a specific agonist of PPARδ, GW501516. The activation of PPARδ had no effect on oocyte maturation for 1 μM and 10 μM GW501516 compared with the control group...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28160207/impact-of-prolonged-oocyte-incubation-time-before-vitrification-on-oocyte-survival-embryo-formation-and-embryo-quality-in-mice
#17
Azade Karami, Mitra Bakhtiari, Mehri Azadbakht, Rostam Ghorbani, Mozafar Khazaei, Mansour Rezaei
Oocyte incubation time before freezing is one of the factors affecting oocyte vitrification. In the assisted reproductive technology (ART) clinics, it is sometimes decided to perform oocyte vitrification after a long period of incubation time due to various conditions, such as inability to collect semen samples, unsuccessful urological interventions (PESA, TESE, etc.), or unexpected conditions. A time factor of up to 6 h has been studied in the available reports. Therefore, this study was designed to evaluate oocyte incubation time before freezing at 0, 6, 12, 18, and 24 h after retrieval...
February 3, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28152037/reassessing-the-feasibility-of-the-zygote-score-for-predicting-embryo-viability-in-ivf-icsi-using-the-gnrh-antagonist-protocol-compared-to-the-long-protocol
#18
Pin-Yao Lin, Fu-Jen Huang, Fu-Tsai Kung, Yi-Chi Lin, Hsin-Ju Chiang, Yu-Ju Lin, Kuo-Chung Lan
BACKGROUND: Many factors from the oocyte/sperm or the process of fertilization may affect the zygote formation. The zygote score (Z-score) describes the quality of a human zygote based on its pronuclear morphology, nucleolar precursor bodies, and alignment of polar bodies, and it can be used in the selection process at the zygote stage for embryo transfer or cryopreservation. OBJECTIVE: The aim of this retrospective cohort study was to investigate the relationship between different controlled ovarian stimulation (COS) protocols and the zygote score (Z-score) and to assess the feasibility of the Z-score for predicting embryo survival in the GnRH-antagonist (GnRH-ant) protocol...
2017: PloS One
https://www.readbyqxmd.com/read/28151020/clinical-outcome-of-cycles-with-oocyte-degeneration-after-intracytoplasmic-sperm-injection
#19
Lanlan Liu, Jiali Cai, Ping Li, Xiaoming Jiang, Jianzhi Ren
There are variant rates of oocyte degeneration after intracytoplasmic sperm injection (ICSI) among different patients. Oocyte degeneration after ICSI may reflect the cohort of oocyte quality and subsequent embryo development capacity and clinical outcome. This retrospective study analyzed 255 cycles with at least one degenerated oocyte after ICSI (degeneration group) and 243 cycles with no degenerated oocytes after ICSI (control group). Basic characteristics like female age, body mass index, duration of infertility, hormone (FSH, LH, E2) levels on day 3 of menses, and primary infertility patient rate were similar between the two groups (p > 0...
February 2, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28139236/time-lapse-imaging-reveals-differences-in-growth-dynamics-of-embryos-after-in%C3%A2-vitro-maturation-compared-with-conventional-stimulation
#20
Sabine Roesner, Jens Erik Dietrich, Julia Weigert, Markus Montag, Bettina Toth, Thomas Strowitzki
OBJECTIVE: To study the impact of in vitro maturation (IVM) on embryonal development with the use of time-lapse imaging. DESIGN: Retrospective case-control study. SETTING: University hospital. PATIENT(S): In total, 294 embryos were cultured after intracytoplasmic sperm injection treatment of three groups: patients with polycystic ovary syndrome (PCOS) and IVM (n = 105; group 1 [G1]), patients after conventional stimulation without PCOS (n = 115; G2) and with PCOS (n = 74; G3)...
January 27, 2017: Fertility and Sterility
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