keyword
MENU ▼
Read by QxMD icon Read
search

brain-derived neurotrophic factor

keyword
https://www.readbyqxmd.com/read/28921694/protease-activated-receptor-2-controls-myelin-development-resiliency-and-repair
#1
Hyesook Yoon, Maja Radulovic, Grant Walters, Alex R Paulsen, Kristen Drucker, Phillip Starski, Jianmin Wu, David P Fairlie, Isobel A Scarisbrick
Oligodendrocytes are essential regulators of axonal energy homeostasis and electrical conduction and emerging target cells for restoration of neurological function. Here we investigate the role of protease activated receptor 2 (PAR2), a unique protease activated G protein-coupled receptor, in myelin development and repair using the spinal cord as a model. Results demonstrate that genetic deletion of PAR2 accelerates myelin production, including higher proteolipid protein (PLP) levels in the spinal cord at birth and higher levels of myelin basic protein and thickened myelin sheaths in adulthood...
September 18, 2017: Glia
https://www.readbyqxmd.com/read/28921568/neuronal-activity-dependent-local-activation-of-dendritic-unfolded-protein-response-promotes-expression-of-brain-derived-neurotrophic-factor-in-cell-soma
#2
Atsushi Saito, Longjie Cai, Koji Matsuhisa, Yosuke Ohtake, Masayuki Kaneko, Soshi Kanemoto, Rie Asada, Kazunori Imaizumi
Unfolded protein response (UPR) has roles not only in resolving the accumulation of unfolded proteins owing to endoplasmic reticulum (ER) stress, but also in regulation of cellular physiological functions. ER stress transducers providing the branches of UPR signaling are known to localize in distal dendritic ER of neurons. These reports suggest that local activation of UPR branches may produce integrated outputs for distant communication, and allow regulation of local events in highly polarized neurons. Here, we demonstrated that synaptic activity- and brain-derived neurotrophic factor (BDNF)-dependent local activation of UPR signaling could be associated with dendritic functions through retrograde signal propagation by using murine neuroblastoma cell line, Neuro-2A and primary cultured hippocampal neurons derived from postnatal day 0 litter C57BL/6 mice...
September 16, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28920182/neovascularization-and-synaptic-function-regulation-with-memantine-and-rosuvastatin-in-a-rat-model-of-chronic-cerebral-hypoperfusion
#3
Nan Zhang, Chenchen Song, Baomin Zhao, Mengya Xing, Lanlan Luo, Marc L Gordon, Yan Cheng
Cerebral hypoperfusion is an important factor in the pathogenesis of cerebrovascular diseases and neurodegenerative disorders. We investigated the effects of memantine and rosuvastatin on both neovascularization and synaptic function in a rat model of chronic cerebral hypoperfusion, which was established by the bilateral common carotid occlusion (2VO) method. We tested learning and memory ability, synaptic function, circulating endothelial progenitor cell (EPC) number, expression of neurotrophic factors, and markers of neovasculogenesis and cell proliferation after memantine and/or rosuvastatin treatment...
September 17, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28915971/genotrophic-effect-of-neurotrophins-restart-of-%C3%AE-cell-regeneration-in-diabetes-mellitus
#4
Mariyana G Hristova
Type 2 diabetes mellitus is an epidemic worldwide and a proved risk factor for cardiovascular complications. In 89% of the cases, it deals, in fact, with metabolic syndrome of multifactorial etiopathogenesis. This paradigm has been generalized by the neurotrophic theory emphasizing the role of hyponeurotrophinemia of key factor. Both type 2 diabetes mellitus and metabolic syndrome are characterized by insulin resistance and pancreatic β-cell damage. Cyclic keeping the fast enhances plasma neurotrophin levels...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28915388/epa-and-dha-but-not-ala-have-antidepressant-effects-with-17%C3%AE-estradiol-injection-via-regulation-of-a-neurobiological-system-in-ovariectomized-rats
#5
Jeong-Eun Choi, Yongsoon Park
Our previous studies found that n-3 polyunsaturated fatty acids (PUFAs) and estrogen had synergistic antidepressant-like effects. The purpose of the present study was to investigate the hypothesis that three major n-3 PUFAs, α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), individually had antidepressant effects combined with 17β-estradiol-3-benzoate (E) through a neurobiological pathway in ovariectomized rats. Rats were fed a modified American Institute of Nutrition-93G diet with 0% n-3 PUFAs and 1% ALA, EPA and DHA relative to total energy intake for 12 weeks and were injected with corn oil or E every 4 days during the last 3 weeks...
August 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28914594/salivary-neuropeptides-stress-and-periodontitis
#6
Hady Haririan, Oleh Andrukhov, Michael Böttcher, Eleonore Pablik, Gernot Wimmer, Andreas Moritz, Xiaohui Rausch-Fan
BACKGROUND: Scientific evidence for psychological stress as a risk factor for periodontitis is fragmentary relying mostly on either questionnaire-based or biomarker studies. The aim of this study was to investigate Brain Derived Neurotrophic Factor, Substance P, Vasoactive Intestinal Peptide (VIP), Neuropeptide Y (NPY), Calcitonin Gene Related Peptide and Adrenomedullin as well as cortisol in saliva and serum in periodontal health and disease combined with different aspects of stress and possible associations with clinical parameters...
September 15, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28914133/age-of-donor-of-human-mesenchymal-stem-cells-affects-structural-and-functional-recovery-after-cell-therapy-following-ischaemic-stroke
#7
Susumu Yamaguchi, Nobutaka Horie, Katsuya Satoh, Takeshi Ishikawa, Tsuyoshi Mori, Hajime Maeda, Yuhtaka Fukuda, Shunsuke Ishizaka, Takeshi Hiu, Yoichi Morofuji, Tsuyoshi Izumo, Noriyuki Nishida, Takayuki Matsuo
Cell transplantation therapy offers great potential to improve impairments after stroke. However, the importance of donor age on therapeutic efficacy is unclear. We investigated the regenerative capacity of transplanted cells focusing on donor age (young vs. old) for ischaemic stroke. The quantities of human mesenchymal stem cell (hMSC) secreted brain-derived neurotrophic factor in vitro and of monocyte chemotactic protein-1 at day 7 in vivo were both significantly higher for young hMSC compared with old hMSC...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28914102/5-httlpr-brain-derived-neurotrophic-factor-bdnf-gene-interactions-and-early-adverse-life-events-effect-on-impulsivity-in-suicide-attempters
#8
Luis Jiménez-Treviño, Pilar Alejandra Saiz, Maria Paz García-Portilla, Hilario Blasco-Fontecilla, Vladimir Carli, Miriam Iosue, Isabelle Jaussent, Jorge López-Castroman, Concepcion Vaquero-Lorenzo, Marco Sarchiapone, Enrique Baca-García, Philippe Courtet, Julio Bobes
OBJECTIVES: An expanding body of research suggests that childhood adverse experiences can lead to different negative health outcomes, including attempted suicide. Serotonergic genes such as the promoter region of the serotonin transporter gene (5-HTTLPR) have been associated both with impulsivity in suicide attempts and reactivity to environmental stress exposure. BDNF gene may play an epigenetic role. METHODS: We studied the influence of childhood stressful events and 5-HTTLPR genotype on impulsivity measured by Barratt Impulsivity Scale (BIS-10) in a multicentre sample of 1,655 suicide attempters (69...
September 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28912711/increased-hippocampal-probdnf-contributes-to-memory-impairments-in-aged-mice
#9
Mona Buhusi, Chris Etheredge, Ann-Charlotte Granholm, Catalin V Buhusi
Memory decline during aging or accompanying neurodegenerative diseases, represents a major health problem. Neurotrophins have long been considered relevant to the mechanisms of aging-associated cognitive decline and neurodegeneration. Mature Brain-Derived Neurotrophic Factor (BDNF) and its precursor (proBDNF) can both be secreted in response to neuronal activity and exert opposing effects on neuronal physiology and plasticity. In this study, biochemical analyses revealed that increased levels of proBDNF are present in the aged mouse hippocampus relative to young and that the level of hippocampal proBDNF inversely correlates with the ability to perform in a spatial memory task, the water radial arm maze (WRAM)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28911966/fluoxetine-administration-during-adolescence-attenuates-cognitive-and-synaptic-deficits-in-adult-3%C3%A3-tgad-mice
#10
Dong-Sheng Sun, Li-Feng Gao, Li Jin, Hao Wu, Qun Wang, You Zhou, Shuhao Fan, Xia Jiang, Dan Ke, Hao Lei, Jian-Zhi Wang, Gong-Ping Liu
Fluoxetine (FLX) has broad neurobiological functions and neuroprotective effects; however, the preventive effects of FLX on cognitive impairments in Alzheimer's disease (AD) have not been reported. Here, we studied whether adolescent administration of fluoxetine can prevent memory deficits in AD transgenic mice that harbour PS1m146v, APPswe and TauP301L mutations (3 × TgAD). FLX was applied through peritoneal injection to the mice at postnatal day 35 (p35) for 15 consecutive days, and the effects of FLX were observed at 6-month...
September 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28906345/folic-acid-exerts-antidepressant-effects-by-upregulating-brain-derived-neurotrophic-factor-and-glutamate-receptor-1-expression-in-brain
#11
Liangcai Gao, Xinnan Liu, Li Yu, Junlin Wu, Mingchu Xu, Yusi Liu
Folic acid is a vitamin with a variety of pharmacological effects. The present study aims to explore the beneficial effects of folic acid on chronic unpredictable mild stress (CUMS)-induced depression-like behaviors and its possible mechanisms. The behavioral tests including open-field test, tail suspension test, and forced swimming test were used to evaluate the antidepressant effects of folic acid. Then the changes of brain 5-hydroxytryptamine (5-HT) concentration, brain-derived neurotrophic factor (BDNF), glutamate receptor 1 (GluR1) expression levels, and synaptic organization were assessed to explore the antidepressant mechanisms of folic acid...
September 12, 2017: Neuroreport
https://www.readbyqxmd.com/read/28905640/neurobiological-mechanisms-of-exercise-and-psychotherapy-in-depression-the-speed-study-rationale-design-and-methodological-issues
#12
Stephan Heinzel, Michael A Rapp, Thomas Fydrich, Andreas Ströhle, Christina Terán, Gunnar Kallies, Melanie Schwefel, Andreas Heissel
BACKGROUND/AIMS: Even though cognitive behavioral therapy has become a relatively effective treatment for major depressive disorder and cognitive behavioral therapy-related changes of dysfunctional neural activations were shown in recent studies, remission rates still remain at an insufficient level. Therefore, the implementation of effective augmentation strategies is needed. In recent meta-analyses, exercise therapy (especially endurance exercise) was reported to be an effective intervention in major depressive disorder...
September 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28904856/mir-101-inhibits-ovarian-carcinogenesis-by-repressing-the-expression-of-brain-derived-neurotrophic-factor
#13
Ying Xu, Lei Xu, Jianbin Zheng, Lei Geng, Shuping Zhao
Ovarian cancer is one of the most lethal malignant gynecological tumors as a result of difficulties in early-stage detection and a lack of effective treatments for patients with advanced or recurrent cancer. In the present study, we aimed to explore whether some of the microRNA (miRNA) content of serum might be related to ovarian cancer, as well as the role of these miRNAs and their intercellular transport via exosomes in ovarian cancer. We first detected the expression of six candidate miRNAs in ovarian cancer tissues and adjacent nontumor ovarian samples from 36 patients and confirmed the altered expression of four miRNAs...
September 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28903900/genetics-association-study-and-functional-analysis-on-osteoporosis-susceptibility-gene-bdnf
#14
Man Yang, Bing-Jie Lu, Yuan-Yuan Duan, Xiao-Feng Chen, Jian-Gang Ma, Yan Guo
To explore the relationship between brain-derived neurotrophic factor (BDNF) gene and bone mineral density (BMD) in Chinese Han population, we performed association analysis of 14 tag SNPs on BDNF gene with hip/spine BMD in 1300 Han Chinese samples from Shaanxi Province. We found that 8 of the 14 SNPs were significantly associated with hip or spine BMD (P < 0.05). Moreover, the SNP rs16917237 was significantly associated with both hip and spine BMD, with significant Bonferroni correlation (P value 0.05/14 = 0...
August 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28903487/from-the-cover-arsenic-induces-hippocampal-neuronal-apoptosis-and-cognitive-impairments-via-an-up-regulated-bmp2-smad-dependent-reduced-bdnf-trkb-signaling-in-rats
#15
Rukmani Pandey, Vipin Rai, Juhi Mishra, Kapil Mandrah, Somendu Kumar Roy, Sanghamitra Bandyopadhyay
Arsenic promotes hippocampal neuronal damage inducing cognitive impairments. However, mechanism arbitrating arsenic-mediated cognitive deficits remains less-known. Here, we identified that chronic exposure to environmentally relevant doses of arsenic increased apoptosis, characterized by caspase-3 activation, poly(ADP-ribose) polymerase cleavage and Terminal deoxynucleotidyl transferase dUTP nick-end labeling of rat hippocampal neurons, marked by NeuN. Investigating apoptotic mechanism through invivo and invitro studies revealed that arsenic promoted bone morphogenetic protein-2 (BMP2) expression, supported by increased BMP-receptor2 (BMPR2) and p-Smad1/5 in hippocampal neurons...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28901458/neuroprotective-effects-of-curcumin-alleviate-lumbar-intervertebral-disc-degeneration-through-regulating-the-expression-of-inos-cox%C3%A2-2-tgf%C3%A2-%C3%AE-1-2-mmp%C3%A2-9-and-bdnf-in-a-rat-model
#16
Yuan Hu, Jin-Shu Tang, Shu-Xun Hou, Xiu-Xiu Shi, Jiang Qin, Tie-Song Zhang, Xiao-Jing Wang
Curcumin is a natural product with antimutagenic, antitumor, antioxidant and neuroprotective properties. However, to the best of our knowledge, curcumin has yet to be investigated for the treatment of lumbar intervertebral disc degeneration LIDD). The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)‑2, transforming growth factor (TGF)‑β1/2, matrix metalloproteinase (MMP)‑9 and brain‑derived neurotrophic factor (BDNF) in a rat model of LIDD...
September 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28901408/microrna%C3%A2-382-inhibits-cell-proliferation-and-invasion-of-retinoblastoma-by-targeting-bdnf%C3%A2-mediated-pi3k-akt-signalling-pathway
#17
Dan Song, Jiandong Diao, Yongjing Yang, Yahong Chen
It has previously been demonstrated that multiple microRNAs (miRNAs or miRs) are aberrantly expressed in retinoblastoma (RB) and contribute to RB initiation and progression. miR‑382 has been revealed to be aberrantly expressed and therefore exhibits a key role in the progression of various types of cancer. However, the expression pattern, functional roles and underlying molecular mechanism of miR‑382 in RB remain unknown. The present study investigated the expression levels of miR‑382 and its effects on RB cells and the underlying regulatory mechanism of its action...
August 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900242/dietary-docosahexaenoic-acid-dha-as-lysophosphatidylcholine-but-not-as-free-acid-enriches-brain-dha-and-improves-memory-in-adult-mice
#18
Dhavamani Sugasini, Riya Thomas, Poorna C R Yalagala, Leon M Tai, Papasani V Subbaiah
Docosahexaenoic acid (DHA) is uniquely concentrated in the brain, and is essential for its function, but must be mostly acquired from diet. Most of the current supplements of DHA, including fish oil and krill oil, do not significantly increase brain DHA, because they are hydrolyzed to free DHA and are absorbed as triacylglycerol, whereas the transporter at blood brain barrier is specific for phospholipid form of DHA. Here we show that oral administration of DHA to normal adult mice as lysophosphatidylcholine (LPC) (40 mg DHA/kg) for 30 days increased DHA content of the brain by >2-fold...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28900183/a-brain-derived-neurotrophic-factor-mimetic-is-sufficient-to-restore-cone-photoreceptor-visual-function-in-an-inherited-blindness-model
#19
Conor Daly, Lisa Shine, Theresa Heffernan, Sudhakar Deeti, Alison L Reynolds, John J O'Connor, Eugène T Dillon, David J Duffy, Walter Kolch, Gerard Cagney, Breandán N Kennedy
Controversially, histone deacetylase inhibitors (HDACi) are in clinical trial for the treatment of inherited retinal degeneration. Utilizing the zebrafish dye (ucd6) model, we determined if treatment with HDACi can rescue cone photoreceptor-mediated visual function. dye exhibit defective visual behaviour and retinal morphology including ciliary marginal zone (CMZ) cell death and decreased photoreceptor outer segment (OS) length, as well as gross morphological defects including hypopigmentation and pericardial oedema...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28900083/-the-effects-of-chronic-alcoholization-on-the-expression-of-brain-derived-neurotrophic-factor-and-its-receptors-in-the-brains-of-mice-genetically-predisposed-to-depressive-like-behavior
#20
D V Bazovkina, E M Kondaurova, A S Tsybko, A I Kovetskaya, T V Ilchibaeva, V S Naumenko
Brain-derived neurotropic factor (BDNF) plays an important role in mechanisms of depression. Precursor protein of this factor (proBDNF) can initiate apoptosis in the brain, while the mature form of BDNF is involved in neurogenesis. It is known that chronic alcoholization leads to the activation of apoptotic processes, neurodegeneration, brain injury, and cognitive dysfunction. In this work, we have studied the influence of long-term ethanol exposure on the proBDNF and BDNF protein levels, as well as on the expression of genes that encode these proteins in the brain structures of ASC mice with genetic predisposition to depressive-like behavior and in mice from parental nondepressive CBA strain...
July 2017: Molekuliarnaia Biologiia
keyword
keyword
37909
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"