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https://www.readbyqxmd.com/read/28199128/sox2-drives-bronchial-dysplasia-in-a-novel-organotypic-model-of-early-human-squamous-lung-cancer
#1
Lúcia L Correia, Jo-Anne Johnson, Peter McErlean, Julien Bauer, Hassan Farah, Doris M Rassl, Robert C Rintoul, Tariq Sethi, Paul Lavender, Emma L Rawlins, Trevor D Littlewood, Gerard I Evan, Frank M McCaughan
Rationale Improving the early detection and chemoprevention of lung cancer are key to improving outcomes. The pathobiology of early squamous lung cancer is poorly understood. We have shown that amplification of SOX2 is an early and consistent event in the pathogenesis of this disease but its functional oncogenic potential remains uncertain. We tested the impact of deregulated SOX2 expression in a novel organotypic system that recreates the molecular and microenvironmental context in which squamous carcinogenesis occurs...
February 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28190677/bornyl-diphosphate-synthase-from-lavandula-angustifolia-a-major-monoterpene-synthase-involved-in-essential-oil-quality
#2
Yolande Despinasse, Sébastien Fiorucci, Serge Antonczak, Sandrine Moja, Aurélie Bony, Florence Nicolè, Sylvie Baudino, Jean-Louis Magnard, Frédéric Jullien
Lavender essential oils (EOs) of higher quality are produced by a few Lavandula angustifolia cultivars and mainly used in the perfume industry. Undesirable compounds such as camphor and borneol are also synthesized by lavender leading to a depreciated EO. Here, we report the cloning of bornyl diphosphate synthase of lavender (LaBPPS), an enzyme that catalyzes the production of bornyl diphosphate (BPP) and then by-products such as borneol or camphor, from an EST library. Compared to the BPPS of Salvia officinalis, the functional characterization of LaBPPS showed several differences in amino acid sequence, and the distribution of catalyzed products...
February 9, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28169902/lavender-for-sleep-rest-and-pain-evidence-for-practice-and-research
#3
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/28169892/lavender-for-sleep-rest-and-pain-evidence-for-practice-and-research
#4
Patricia Anne OʼMalley
No abstract text is available yet for this article.
March 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/28169850/american-contact-dermatitis-society-core-allergen-series-2017-update
#5
Peter C Schalock, Cory A Dunnick, Susan Nedorost, Bruce Brod, Erin Warshaw, Christen Mowad
The American Contact Dermatitis Society Core Allergen Series was introduced in 2012. After 4 years of use, changes in our recommended allergens are necessary. For the updated series, we have reordered the first 4 panels to approximately mirror the current TRUE Test and removed parthenolide, triclosan, glutaraldehyde, and jasmine. Polymyxin B, lavender, sodium benzoate, ethylhexylglycerin, and benzoic acid are new additions to the American Contact Dermatitis Society series.
February 6, 2017: Dermatitis
https://www.readbyqxmd.com/read/28166686/antidepressant-and-anxiolytic-activity-of-lavandula-officinalis-aerial-parts-hydroalcoholic-extract-in-scopolamine-treated-rats
#6
Batool Rahmati, Zahra Kiasalari, Mehrdad Roghani, Mohsen Khalili, Fariba Ansari
CONTEXT: Anxiety and depression are common in Alzheimer's disease (AD). Despite some evidence, it is difficult to confirm Lavandula officinalis Chaix ex Vill (Lamiaceae) as an anxiolytic and antidepressant drug. OBJECTIVE: The effects of L. officinalis extract were studied in scopolamine-induced memory impairment, anxiety and depression-like behaviour. MATERIALS AND METHODS: Male NMRI rats were divided into control, scopolamine alone-treated group received scopolamine (0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28166628/more-than-honey-investigations-on-volatiles-from-monovarietal-honeys-by-using-new-analytical-and-sensory-approaches
#7
Barbara Siegmund, Katharina Urdl, Andrea Jurek, Erich Leitner
Eight monovarietal honeys from dandelion, fir tree, linden tree, chestnut tree, robinia, orange, lavender and rape were investigated with respect to their volatile compounds and their sensory properties. Analysis of the volatile compounds was performed by gas chromatographic tech-niques (one-dimensional GC-MS as well as comprehensive GC x GC-MS). For sensory eva-luation Napping® in combination with ultra flash profiling was applied using sensory experts. For dandelion honey, 34 volatiles compounds are described for the first time to be present in dandelion honey...
February 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28156673/palliative-whole-brain-radiotherapy-predictors-of-prescribing-5-versus-10-fractions
#8
Sarah Baker, Kim Paulson, Brock J Debenham, Sunita Ghosh, David L Ma, Fleur Huang, Karen P Chu, Diane Severin, John Amanie, Tirath Nijjar, Samir Patel, Ericka Wiebe, Brita Lavender Danielson, Bronwen LeGuerrier, Alysa M Fairchild
: 219 Background: The optimal dose for palliative whole brain radiotherapy (WBRT) continues to be debated. Common regimens include 20 Gy in five and 30 Gy in 10 fractions. We aimed to identify factors associated with WBRT dose schedules, hypothesizing that clinical prediction of survival (CPS) would influence prescribing practice. METHODS: Demographic and clinicopathologic data were collected for consecutive patients with brain metastases receiving WBRT through a dedicated palliative radiation oncology clinic...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156672/attitude-and-support-to-inform-clinical-predictions-of-survival-in-patients-with-advanced-cancer
#9
David L Ma, Kim Paulson, Sunita Ghosh, Bronwen LeGuerrier, Karen P Chu, Diane Severin, Fleur Huang, Sharon Watanabe, Ann Huot, John Amanie, Samir Patel, Tirath Nijjar, Ericka Wiebe, Brita Lavender Danielson, Brock J Debenham
: 39 Background: Tumour factors (eg primary site, size) helpful in prognostication in early stage cancer may be less important than patient factors, such as Karnofsky performance status (KPS), later in the disease trajectory. We evaluated the utilization of the parameters attitude (ATT) and psychosocial support (PSS) in predicting remaining lifespan by two experienced multidisciplinary teams (MDT). METHODS: After clinical assessment of consecutive patients, a quantitative clinical prediction of survival (CPS) was made prospectively, independently and anonymously by each health care provider (HCP)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156489/the-evolving-radiation-therapist-role-in-a-multidisciplinary-palliative-radiotherapy-clinic
#10
Fleur Huang, Winter Spence, Brenda Rose, Jacqueline Middleton, Megan Palen, Kitta Thavone, Shazma Ravji, Brita Lavender Danielson, Alysa M Fairchild
: 158 Background: Radiation therapists (MRTT) have been integrated in varying capacities into outpatient palliative radiotherapy (PRT) services across Canada for nearly two decades. We explored the experience of our centre's MRTTs who have developed an essential role over nine years, from supporting one half-day PRT clinic per week to five full days of clinical, technical, research, and administrative involvement. METHODS: An electronic survey was distributed to all 12 MRTTs who contributed to the PRT program (2007-2016), which was later supplemented by in-person semi-structured interviews...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28154606/lavandula-angustifolia-mill-oil-and-its-active-constituent-linalyl-acetate-alleviate-pain-and-urinary-residual-sense-after-colorectal-cancer-surgery-a-randomised-controlled-trial
#11
So Hyun Yu, Geun Hee Seol
Pain and urinary symptoms following colorectal cancer (CRC) surgery are frequent and carry a poor recovery. This study tested the effects of inhalation of Lavandula angustifolia Mill. (lavender) oil or linalyl acetate on pain relief and lower urinary tract symptoms (LUTS) following the removal of indwelling urinary catheters from patients after CRC surgery. This randomised control study recruited 66 subjects with indwelling urinary catheters after undergoing CRC surgery who later underwent catheter removal...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28143493/the-yin-yan-of-ccl2-a-minor-role-in-neutrophil-anti-tumor-activity-in-vitro-but-a-major-role-on-the-outgrowth-of-metastatic-breast-cancer-lesions-in-the-lung-in-vivo
#12
Nicole Lavender, Jinming Yang, Sheau-Chiann Chen, Jiqing Sai, C Andrew Johnson, Philip Owens, Gregory D Ayers, Ann Richmond
BACKGROUND: The role of the chemokine CCL2 in breast cancer is controversial. While CCL2 recruits and activates pro-tumor macrophages, it is also reported to enhance neutrophil-mediated anti-tumor activity. Moreover, loss of CCL2 in early development enhances breast cancer progression. METHODS: To clarify these conflicting findings, we examined the ability of CCL2 to alter naïve and tumor entrained neutrophil production of ROS, release of granzyme-B, and killing of tumor cells in multiple mouse models of breast cancer...
January 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28138552/anti-myeloperoxidase-antibodies-attenuate-the-monocyte-response-to-lps-and-shape-macrophage-development
#13
Reena J Popat, Seran Hakki, Alpesh Thakker, Alice M Coughlan, Julie Watson, Mark A Little, Corinne M Spickett, Paul Lavender, Behdad Afzali, Claudia Kemper, Michael G Robson
Anti-neutrophil cytoplasmic antibody (ANCA) vasculitis is characterized by the presence of autoantibodies to myeloperoxidase and proteinase-3, which bind monocytes in addition to neutrophils. While a pathological effect on neutrophils is acknowledged, the impact of ANCA on monocyte function is less well understood. Using IgG from patients we investigated the effect of these autoantibodies on monocytes and found that anti-myeloperoxidase antibodies (MPO-ANCA) reduced both IL-10 and IL-6 secretion in response to LPS...
January 26, 2017: JCI Insight
https://www.readbyqxmd.com/read/28129307/comfortably-numb-the-role-of-momentary-dissociation-in-the-experience-of-negative-affect-around-binge-eating
#14
Tyler B Mason, Jason M Lavender, Stephen A Wonderlich, Howard Steiger, Li Cao, Scott G Engel, James E Mitchell, Ross D Crosby
Evidence suggests that both dissociation and negative affect (NA) may precipitate binge eating. The extent to which dissociation may impact the experience of NA around binge eating is unclear. Women with bulimia nervosa completed a 2-week ecological momentary assessment protocol of dissociation, NA, and binge eating. Multilevel modeling was used to examine dissociation as a moderator of NA before and after binge eating. NA was greater at the time of binge eating for participants higher in average dissociation (between subjects) and when momentary dissociation was greater than one's average (within subjects)...
January 26, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28117906/the-effects-of-psychotherapy-treatment-on-outcome-in-bulimia-nervosa-examining-indirect-effects-through-emotion-regulation-self-directed-behavior-and-self-discrepancy-within-the-mediation-model
#15
Carol B Peterson, Kelly C Berg, Ross D Crosby, Jason M Lavender, Erin C Accurso, Anna C Ciao, Tracey L Smith, Marjorie Klein, James E Mitchell, Scott J Crow, Stephen A Wonderlich
OBJECTIVE: The purpose of this investigation was to examine the indirect effects of Integrative Cognitive-Affective Therapy (ICAT-BN) and Cognitive-Behavioral Therapy-Enhanced (CBT-E) on bulimia nervosa (BN) treatment outcome through three hypothesized maintenance variables: emotion regulation, self-directed behavior, and self-discrepancy. METHOD: Eighty adults with BN were randomized to 21 sessions of ICAT-BN or CBT-E. A regression-based bootstrapping approach was used to test the indirect effects of treatment on outcome at end of treatment through emotion regulation and self-directed behavior measured at mid-treatment, as well as the indirect effects of treatment at follow-up through emotion regulation, self-directed behavior, and self-discrepancy measured at end of treatment...
January 24, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28114805/change-in-caco-2-cells-following-treatment-with-various-lavender-essential-oils
#16
M G Donadu, D Usai, V Mazzarello, P Molicotti, S Cannas, M G Bellardi, S Zanetti
Lavender is an aromatic evergreen shrub diffused in the Mediterranean basin appreciated since antiquity. The genus Lavandula is part of Lamiaceae family and includes more than 20 species, among which true lavender (L. vera D.C. or L. angustifolia Miller.) and spike lavender (L. latifolia Medikus); there are also numerous hybrids known as lavandins (L. hybrida Rev.). L. vera, spike lavender and several hybrids are the most intensely used breeding species for the production of essential oils. Lavender and lavandin essential oils have been applied in food, pharmaceutical and other agro industries as biological products...
January 23, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28111415/permeation-of-limonene-through-disposable-nitrile-gloves-using-a-dextrous-robot-hand
#17
Sean Banaee, Shane S Que Hee
OBJECTIVES: The purpose of this study was to investigate the permeation of the low-volatile solvent limonene through different disposable, unlined, unsupported, nitrile exam whole gloves (blue, purple, sterling, and lavender, from Kimberly-Clark). METHODS: This study utilized a moving and static dextrous robot hand as part of a novel dynamic permeation system that allowed sampling at specific times. Quantitation of limonene in samples was based on capillary gas chromatography-mass spectrometry and the internal standard method (4-bromophenol)...
January 21, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28109409/ecco-essential-requirements-for-quality-cancer-care-soft-tissue-sarcoma-in-adults-and-bone-sarcoma-a-critical-review
#18
REVIEW
Elisabeth Andritsch, Marc Beishon, Stefan Bielack, Sylvie Bonvalot, Paolo Casali, Mirjam Crul, Roberto Delgado- Bolton, Davide Maria Donati, Hassan Douis, Rick Haas, Pancras Hogendoorn, Olga Kozhaeva, Verna Lavender, Jozsef Lovey, Anastassia Negrouk, Philippe Pereira, Pierre Roca, Godelieve Rochette de Lempdes, Tiina Saarto, Bert van Berck, Gilles Vassal, Markus Wartenberg, Wendy Yared, Alberto Costa, Peter Naredi
BACKGROUND: ECCO essential requirements for quality cancer care (ERQCC) are checklists and explanations of organisation and actions that are necessary to give high-quality care to patients who have a specific tumour type. They are written by European experts representing all disciplines involved in cancer care. ERQCC papers give oncology teams, patients, policymakers and managers an overview of the elements needed in any healthcare system to provide high quality of care throughout the patient journey...
February 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28098847/polish-yellow-sweet-clover-melilotus-officinalis-l-honey-chromatographic-fingerprints-and-chemical-markers
#19
Izabela Jasicka-Misiak, Ewa Makowicz, Natalia Stanek
A case study of Polish Melilotus officinalis honey was presented for the first time. Gas chromatography-mass spectrometry (GC-MS) (after steam distillation, Soxhlet extraction, ultrasonic solvent extraction, and solid phase extraction (SPE)) and targeted high performance liquid chromatography with a photodiode array detector (HPLC-PAD) were applied to determine the characteristic components of honey. While ubiquitous in most honeys, carbohydrates, terpene derivatives, and phenylacetic acid dominated in the Soxhlet extracts (25...
January 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28095143/-the-madness-of-the-carnival-representations-of-latin-america-and-the-caribbean-in-the-u-s-homophile-press
#20
Shlomo Gleibman
This essay examines representations of Latin America and the Caribbean in U.S. homophile periodicals from 1953 to 1964. The 120 items in ONE, Mattachine Review, and The Ladder that referenced this region depicted Latin America and the Caribbean as different from the United States in a number of ways, in particular as more sexually repressive or more sexually liberal. These representations typically conformed to the general homophile movement tendency to challenge U.S. anti-homosexual campaigns during the "Lavender Scare," while arguing for acceptance based on rights claims...
January 17, 2017: Journal of Homosexuality
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