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Aphthous ulcer

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https://www.readbyqxmd.com/read/28922104/interleukin-2-interferon-gamma-gene-polymorphisms-in-recurrent-aphthous-stomatitis
#1
Shamsolmoulouk Najafi, Hila Yousefi, Mahsa Mohammadzadeh, Alireza Zare Bidoki, Elham Farhadi, Nima Rezaei
Recurrent aphthous stomatitis (RAS) is the most common oral ulcerative inflammatory disease with unknown etiology. IL-2 and IFN-γ are secreted by Th1 cells and the elevated levels of them have been reported in RAS. Single nucleotide polymorphisms (SNPs) of IL-2 and IFN-γ genes could alter the cytokine production. The aim of this study was to investigate frequencies of IL-2 and IFN-γ alleles and genotypes in a group of patients with minor-RAS (MiRAS). PCR-SSP method used to type genomic DNA of 64 Iranian patients with MiRAS for IL-2 gene (G -330 T) and (G +166 T) and IFN-γ gene at position UTR5644 (A/T)...
2017: Prague Medical Report
https://www.readbyqxmd.com/read/28916023/beh%C3%A3-et-disease-new-aspects
#2
Isil Bulur, Meltem Onder
Behçet disease is currently considered an "autoinflammatory disease" triggered by infection and environmental factors in genetically predisposed individuals. Although the disease is characterized by recurrent oral and genital aphthous ulcers and ocular involvement, it can affect multiple organ systems. Complex aphthosis is characterized by recurrent oral and/or genital aphthous ulcers. It is important to evaluate the patient with complex aphthosis for Behçet disease and related systemic disorders. We discuss the etiopathogenesis, clinical features, diagnostic criteria, and treatment approaches for complex aphthosis and Behçet disease in light of the current literature...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28915309/genital-aphthous-ulcers-and-a-case-of-suspected-chikungunya-a-short-clinical-case
#3
Frances A Martinez-Díaz
Genital aphthous ulcers can result from multiple conditions including febrile syndromes. Chikungunya infection manifests mainly as fever accompanied by polyarthralgia and pruritic rash. Nevertheless, healthcare providers should be alert to additional presentations. This is the case of a young woman presenting with painful genital ulcers after a three day prodome of fever and polyarthralgia. As a suspected case of Chikungunya infection and a clinical diagnosis of aphthae, treatment with oral prednisone for two weeks produced complete resolution of ulcers with no scarring...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28828164/oral-manifestations-as-the-first-presenting-sign-of-crohn-s-disease-in-a-pediatric-patient
#4
Ashley Eckel, Dale Lee, Gail Deutsch, Anthony Maxin, Dolphine Oda
Crohn's disease (CD) is a chronic inflammatory disorder affecting the gastrointestinal (GI) tract. Although the GI tract is the primary site of involvement, many patients, particularly in pediatric cases, first present with non-intestinal manifestations, including oral lesions. Oral manifestations of CD in children occur in around 50-80% of cases, and about 30% of CD cases in children occur first in the mouth. Recognizing such oral lesions in the pediatric population, and requesting a biopsy, may expedite the diagnosis of CD...
July 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28702966/possible-role-of-helicobacter-pylori-in-diseases-of-dermatological-interest
#5
C Guarneri, J Lotti, M Fioranelli, M G Roccia, T Lotti, F Guarneri
Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. pylori infection were suggested in diseases of dermatological interest such as chronic urticaria, rosacea, Henoch-Schoenleins purpura, idiopathic thrombocytopenic purpura, cutaneous and oral lichen planus, atopic dermatitis, recurrent aphthous stomatitis, systemic sclerosis, psoriasis, Sjögrens syndrome, Behçet's disease, pruritus, alopecia areata, primary cutaneous marginal zone B-cell lymphomas, vitiligo, chronic prurigo, multiformis, prurigo nodularis, leukocytoclastic vasculitis, prurigo pigmentosa, eczema nummulare, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, Sweet's syndrome, cutaneous T-cell pseudolymphoma and pemphigus vulgaris...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28675014/-soluble-programmed-death-1-and-soluble-programmed-death-ligand-1-protein-expression-and-immune-status-in-patients-with-recurrent-aphthous-ulcer
#6
Jiang Nan, Luo Liang, Liu Li, Sun Xiaoqin, Jiang Xing, Cai Yang
OBJECTIVE: This study aims to investigate the possible role and significance of soluble programmed death-1 (sPD-1)  /soluble programmed death ligand 1 (sPD-L1) in the immune pathogeneses of recurrent aphthous ulcer (RAU). METHODS: A total of 30 RAU cases (18 cases of minor RAU, 5 cases of major RAU, and 7 cases of herpetiform ulcers) were enrolled in this study. A total of 18 healthy people served as controls. Lymphocyte subsets (CD3⁺, CD4⁺, CD8⁺, CD19⁺, and CD16⁺+56⁺) were investigated by flow cytometric analysis...
June 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28573247/in-vitro-study-of-concentration-effect-and-time-course-pattern-of-white-alum-on-escherichia-coli-o157-h7-growth
#7
Reza Shahriari, Saeed Salari, Saeed Shahriari
BACKGROUND: Nowadays, the demand for antibacterial fabrics has increased. White alum is used for oral aphthous ulcers treatment in traditional medicine of Sistan city, Sistan and Baluchistan Province, Iran, and also as a flocculent for water purification. This study is aimed to evaluate the effect of concentration and time on antibacterial activity of white alum on Escherichia coli O157:H7. MATERIALS AND METHODS: 0.25, 0.5, 1 and 2% concentrations of white alum were added to 10(8) CFU of Escherichia coli O157:H7...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28572831/the-effect-of-pudilan-anti-inflammatory-oral-liquid-on-the-treatment-of-mild-recurrent-aphthous-ulcers
#8
Ying Jin, Xiaoping Lin, Liming Song, Mengnan Liu, Ying Zhang, Xiangmin Qi, Danping Zhao
Recurrent aphthous ulcers are the most common recurrent oral mucosal lesions characterized by recurrence and pain. The aim of this research is to evaluate the short-term curative effect of the traditional Chinese medicine "Pudilan anti-inflammatory oral liquid" on mild recurrent aphthous ulcers. A total of 234 patients were divided into a treatment group and a control group. Both groups used vitamin B2 as the basis of treatment. The treatment group took a Pudilan anti-inflammatory oral solution for 8 days while the control group was given a liquid placebo...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28569171/oral-mucosal-lesions-in-teenagers-a-cross-sectional-study
#9
Francesca Amadori, Elena Bardellini, Giulio Conti, Alessandra Majorana
BACKGROUND: Adolescence is a period of transition to adulthood. Little is known about oral mucosal lesions (OMLs) in teenagers, in which the emergence of new habits, unfamiliar to children, could affect the type of lesions. The aim of this study was to evaluate the distribution of oral mucosal lesions (OMLs) in a wide sample of adolescents. METHODS: A retrospective cross-sectional study was carried out examining all medical records of adolescents (aged 13-18 years) treated at the Dental Clinic of the University of Brescia (Italy) in the period from 2008 to 2014...
May 31, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28554949/atypical-presentation-of-syphilis-as-an-aphthous-ulcer
#10
Diane J Lu, Ariella Zbar
No abstract text is available yet for this article.
May 29, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28543912/association-study-of-interleukin-1-family-interleukin-6-and-its-receptor-gene-polymorphisms-in-patients-with-recurrent-aphthous-stomatitis
#11
Lydie Izakovicova Holla, Simona Valova, Petra Borilova Linhartova, Jirina Bartova, Jitka Petanova, Pavel Kuklinek, Antonin Fassmann
BACKGROUND: Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population. METHODS: A total of 248 subjects, 184 healthy controls, and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86 bp variable number of tandem repeats (VNTRs) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C, and IL-6R+48992A>C by polymerase chain reaction (PCR) methods...
May 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28511497/assessment-of-oxidant-antioxidant-status-and-stress-factor-in-recurrent-aphthous-stomatitis-patients-case-control-study
#12
Sherin Ziaudeen, Rathy Ravindran
INTRODUCTION: Despite its vast occurrence, the aetiology of Recurrent Aphthous Stomatitis (RAS) still remains unknown and its aetiology is multifactorial. The factors believed to be associated with the aetiology of RAS, may disturb the equilibrium of oxidant-antioxidant status of the organism and may accelerate the formation of free radicals, resulting in Oxidative Stress (OS). Psychological stress is believed to act as a triggering factor or modifying factor for RAS. AIM: To find whether oxidant-antioxidant status and psychosocial stress play a role in the pathogenesis of RAS...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28501878/-oral-manifestations-of-ulcerative-colitis
#13
C X W Tan, H S Brand, N K H de Boer, T Forouzanfar
Ulcerative colitis is an inflammatory bowel disease occurring relatively frequently in industrialised regions of the world. Pyostomatitis vegetans is the most characteristic pathognomonic oral manifestation but other oral abnormalities like aphthous lesions, caries and periodontitis are more prevalent in patients with ulcerative colitis. Oral care providers must be aware of these problems if they are to provide adequate oral care.
May 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28480862/influence-of-ozone-therapy-on-oral-tissue-in-modeling-of-chronic-recurrent-aphthous-stomatitis
#14
I Kovach, L Kravchenko, Yu Khotimska, R Nazaryan, V Gargin
Chronic recurrent aphthous stomatitis (CRAS) belongs to the group of chronic, inflammatory, ulcerative diseases of the oral mucosa. The aim of this study was to determine the effects of ozone on the morphofunctional peculiarities of the soft tissues in modeling chronic recurrent aphthous stomatitis. We performed experimental investigation for study of the morpho-functional state of tissues of the oral mucosa in CRAS with using of previously proposed and widely used modeling scheme with ovalbumin and aluminum hydroxide...
March 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28412856/investigating-the-role-of-il-33-in-the-pathogenesis-of-beh%C3%A3-et-s-disease
#15
Pamir Çerçi, Seda Altıner, Ali İnal, Kenan Köse, Göksal Keskin, Ümit Ölmez
OBJECTIVES: Behçet's disease (BD) is an inflammatory disease, characterized by oral aphthous lesions, recurrent uveitis, skin lesions, and genital ulcerations. Increased release of several cytokines may play a role in the inflammatory stages of BD. IL-33, a member of the IL-1 cytokine superfamily, plays an important role in inflammation. We analyzed serum IL-33 concentration in BD patients to assess its possible role in the pathophysiology of this disease. METHODS: The study included 54 BD patients, 31 with active BD and 23 with inactive BD as well as 18 matched healthy controls...
April 17, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28410620/resolution-of-recurrent-aphthous-ulcers-after-discontinuation-of-cow-s-milk-protein-intake
#16
Nita Chainani-Wu, Anuradha Nayudu
BACKGROUND AND OVERVIEW: Authors of published studies have reported elevated levels of circulating antibodies to cow's milk protein (CMP) in patients with recurrent aphthous ulcers (RAUs), and authors of case reports have described resolution of RAU after dairy elimination. CASE DESCRIPTION: A 10-year-old girl and an 11-year-old boy, both with 5-year histories of frequent RAU episodes, with multiple ulcerations, underwent dairy elimination trials. Both were free of oral ulcers within 2 weeks of discontinuing CMP and remained so with a CMP-free diet...
April 12, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28410605/frosted-branch-angiitis-and-cerebral-venous-sinus-thrombosis-as-an-initial-onset-of-neuro-beh%C3%A3-et-s-disease-a-case-report-and-review-of-the-literature
#17
REVIEW
Bruno Fortaleza de Aquino Ferreira, Ever Ernesto Caso Rodriguez, Leandro Lara do Prado, Celio Roberto Gonçalves, Carlos Eduardo Hirata, Joyce Hisae Yamamoto
BACKGROUND: Frosted branch angiitis is a rare, severe condition. It can be either a primary or a secondary condition and is characterized by rapid deterioration of vision and fulminant retinal vasculitis that manifests as diffuse sheathing of retinal vessels, macular edema, papillitis, vitritis and anterior uveitis. We aimed to describe a case of frosted branch angiitis and cerebral venous sinus thrombosis as an initial neuro-Behçet's disease onset. Diagnosis of Behçet's disease was based on the current 2014 International Criteria for Behçet's Disease and the International consensus recommendation criteria for neuro-Behçet's disease...
April 15, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28360966/recurrent-aphthous-stomatitis-a-review
#18
REVIEW
Natalie Rose Edgar, Dahlia Saleh, Richard A Miller
Aphthous stomatitis is a painful and often recurrent inflammatory process of the oral mucosa that can appear secondary to various well-defined disease processes. Idiopathic recurrent aphthous stomatitis is referred to as recurrent aphthous stomatitis. The differential diagnosis for recurrent aphthous ulcerations is extensive and ranges from idiopathic benign causes to inherited fever syndromes, to connective tissue disease, or even inflammatory bowel diseases. A thorough history and review of systems can assist the clinician in determining whether it is related to a systemic inflammatory process or truly idiopathic...
March 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28359996/treatment-of-recurrent-aphthous-stomatitis-with-er-cr-ysgg-laser-irradiation-a-randomized-controlled-split-mouth-clinical-study
#19
RANDOMIZED CONTROLLED TRIAL
Hasan Guney Yilmaz, Mohammed Rateb Albaba, Ayse Caygur, Esra Cengiz, Fatma Boke-Karacaoglu, Hayriye Tumer
The present randomized controlled split mouth clinical study aimed to investigate the efficacy of Er,Cr:YSGG laser irradiation on pain reduction and healing rate of recurrent aphthous stomatitis. 40 patients with RAS were recruited for this study and RAS ulcerations of each patient were randomly assigned to the control or test group. In the test group, Er,Cr:YSGG laser with non-contact mode was used to irradiate RAS lesions. In the placebo group, RAS lesions were irradiated with the same device without laser emission...
May 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28358035/oral-health-status-in-sichuan-province-findings-from-the-oral-health-survey-of-sichuan-2015-2016
#20
Wei Yin, Ying-Ming Yang, Hong Chen, Xue Li, Zhuo Wang, Li Cheng, Qiu-Dan Yin, Hong-Zhi Fang, Wei Fei, Fang-Lin Mi, Min-Hai Nie, Tao Hu, Xue-Dong Zhou
To investigate oral health status in the residents of Sichuan Province, southwest China, a cross-sectional study was performed using the latest Oral Health Survey Basic Methods recommended by the World Health Organization. A multistage stratified random cluster-sampling method was used to enroll participants from the following three groups: children aged 3-5 years, adolescents aged 12 years, and people aged 65-74 years. In these three groups, the mean numbers of teeth that were affected by caries were 3.28, 0...
March 2017: International Journal of Oral Science
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