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https://www.readbyqxmd.com/read/30007147/intellectual-disability-content-within-pre-registration-nursing-curriculum-how-is-it-taught
#1
Julian N Trollor, Claire Eagleson, Beth Turner, Carmela Salomon, Andrew Cashin, Teresa Iacono, Linda Goddard, Nicholas Lennox
BACKGROUND: Despite experiencing higher rates of physical and mental health conditions compared with the general population, people with intellectual disability face inequitable access to healthcare services. Improving education of healthcare professionals is one way to reduce these inequalities. OBJECTIVE: To determine how intellectual disability content is taught within Australian nursing schools. DESIGN: A two-phase audit of Australian nursing curricula content was conducted using an interview and online survey...
July 7, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/30007138/evaluation-of-the-virtues-and-pitfalls-in-an-hiv-screening-algorithm-based-on-two-fourth-generation-assays-a-step-towards-an-improved-national-algorithm
#2
Boaz Avidor, Daniel Chemtob, Dan Turner, Irene Zeldis, Shirley Girshengorn, Natalia Matus, Svetlana Achsanov, Simona Gielman, Inbal Schweizer, Lilya Baskin, Licita Schreiber, Zipi Kra-Oz
BACKGROUND: Fourth-generation immunoassays used for HIV screening, simultaneously detect anti-HIV antibodies and HIV-1 P24 antigen, but are prone to false-positive results. Usually, they are followed by highly specific third-generation assay, able to differentiate between HIV-1/2 infections. In Israel, screening algorithm is based on consecutive testing by two fourth-generation assays and confirmation by a third-generation test. OBJECTIVES: To evaluate the performance of this algorithm...
July 9, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/30006958/risk-factors-for-diabetes-are-higher-among-non-heterosexual-us-high-school-students
#3
Lauren B Beach, Blair Turner, Dylan Felt, Rachel Marro, Gregory L Phillips
Low physical activity (PA), high sedentary behavior (SB), and overweight and obesity have been shown to associate with increased Type 2 diabetes risk among adolescents. We investigated PA, SB, and overweight and obesity among Youth Risk Behavior Survey (YRBS) respondents to determine if non-heterosexual youth may be at increased diabetes risk compared to heterosexual youth. Weighted city and state YRBS data were pooled across 44 jurisdictions biennially from 2009-2015, resulting in a sample size of 350,673 students...
July 13, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/30006489/cannabinoids-the-heart-of-the-matter
#4
REVIEW
Naghum Alfulaij, Franziska Meiners, Justin Michalek, Andrea L Small-Howard, Helen C Turner, Alexander J Stokes
No abstract text is available yet for this article.
July 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30005803/variability-and-profiles-of-lipophilic-toxins-in-bivalves-from-great-britain-during-five-and-a-half-years-of-monitoring-okadaic-acid-dinophysis-toxins-and-pectenotoxins
#5
Monika Dhanji-Rapkova, Alison O'Neill, Benjamin H Maskrey, Lewis Coates, Mickael Teixeira Alves, Rebecca J Kelly, Robert G Hatfield, Stephanie J Rowland-Pilgrim, Adam M Lewis, Myriam Algoet, Andrew D Turner
Official control biotoxin testing of bivalve molluscs from Great Britain has been conducted by Cefas for over a decade. Reflecting the changes in legislation, bioassays were gradually replaced by analytical methods, firstly for analysis of Paralytic shellfish toxins, followed by introduction of liquid chromatography tandem mass spectrometric (LCMS/MS) method for lipophilic toxins (LTs) in 2011. Twelve compounds, representing three main groups of regulated lipophilic toxins, as well as two non-regulated cyclic imines were examined in over 20,500 samples collected between July 2011 and December 2016...
July 2018: Harmful Algae
https://www.readbyqxmd.com/read/30005756/informing-a-priori-sample-size-estimation-in-qualitative-concept-elicitation-interview-studies-for-clinical-outcome-assessment-instrument-development
#6
Diane M Turner-Bowker, Roger E Lamoureux, Jonathan Stokes, Leighann Litcher-Kelly, Nina Galipeau, Andrew Yaworsky, Jeffrey Solomon, Alan L Shields
OBJECTIVE: Evidence-based recommendations for the a priori estimation of sample size are needed for qualitative concept elicitation (CE) interview studies in clinical outcome assessment (COA) instrument development. Saturation is described as the point at which no new data is expected to emerge from the conduct of additional qualitative interviews. STUDY DESIGN: A retrospective evaluation of 26 CE interview studies conducted with patients between 2006 and 2013 was completed to assess the point at which saturation of concept was achieved in each study...
July 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/30005242/development-validation-and-application-of-a-novel-hplc-ms-ms-method-for-the-quantification-of-atorvastatin-bisoprolol-and-clopidogrel-in-a-large-cardiovascular-patient-cohort
#7
Richard Myles Turner, Vanessa Fontana, Mark Bayliss, Sarah Whalley, Anahi Santoyo Castelazo, Munir Pirmohamed
Cardiovascular disease is a leading cause of morbidity, mortality, and healthcare expenditure worldwide. Importantly, there is interindividual variation in response to cardiovascular medications, leading to variable efficacy and adverse events. Therefore a rapid, selective, sensitive and reproducible multi-analyte HPLC-MS/MS assay for the quantification in human plasma of atorvastatin, its major metabolites 2-hydroxyatorvastatin, atorvastatin lactone and 2-hydroxyatorvastatin lactone, plus bisoprolol and clopidogrel-carboxylic acid has been developed, fully validated, and applied to a large patient study...
July 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30004605/repurposing-the-cord-blood-bank-for-haplobanking-of-hla-homozygous-ipscs-and-their-usefulness-to-multiple-populations
#8
Suji Lee, Ji Young Huh, David M Turner, Soohyeon Lee, James Robinson, Jeremy E Stein, Sung Han Shim, Chang Pyo Hong, Myung Seo Kang, Masato Nakagawa, Shin Kaneko, Mahito Nakanishi, Mahendra S Rao, Andreas Kurtz, Glyn N Stacey, Steven G E Marsh, Marc L Turner, Jihwan Song
Although autologous induced pluripotent stem cells (iPSCs) can potentially be useful for treating patients without immune rejection, in reality it will be extremely expensive and labor-intensive to make iPSCs to realize personalized medicine. An alternative approach is to make use of human leukocyte antigen (HLA) haplotype homozygous donors to provide HLA matched iPSC products to significant numbers of patients. In order to establish a haplobank of iPSCs, we repurposed the cord blood bank by screening ~4,200 high resolution HLA typed cord blood samples, and selected those homozygous for the ten most frequent HLA-A,-B,-DRB1 haplotypes in the Korean population...
July 13, 2018: Stem Cells
https://www.readbyqxmd.com/read/30003703/the-quest-for-accuracy-of-blood-pressure-measuring-devices
#9
Eoin O'Brien, George S Stergiou, Martin J Turner
The accuracy of blood pressure (BP) measuring devices is fundamental to good practice and scientific research. International guidelines on BP measurement are provided for clinicians who diagnose and treat patients with hypertension, clinical researchers who conduct trials on the efficacy of BP lowering drugs and interventional strategies, epidemiologists who conduct population surveys to determine the demographic consequences of hypertension on society, and researchers who perform meta-analyses on published research to further influence the practice of medicine and the provision of resources...
July 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/30003206/geoff-cloke-at-65-a-pioneer-in-organometallic-chemistry
#10
EDITORIAL
Polly L Arnold, Jennifer C Green, Malcolm L H Green, Alexander F R Kilpatrick, Richard A Layfield, Jason B Love, Dermot O'Hare, John F C Turner
Professor Geoff Cloke FRS celebrates his 65th birthday in 2018. In a career spanning four decades, his research endeavours have accounted for some of the most innovative synthetic chemistry of the modern era, with his many publications describing truly exceptional compounds and experimental methods that portray a unique chemical imagination. In addition to his scientific accomplishments, Cloke can be particularly proud of his successful mentoring, a level of dedication that propelled many students and post-docs on to become research leaders in their own right...
July 13, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/30002922/delivery-of-immunomodulatory-microparticles-in-a-murine-model-of-rotator-cuff-tear
#11
Jack R Krieger, Mary Caitlin P Sok, Thomas C Turner, Edward A Botchwey
Full thickness rotator cuff tears (RCT) and the associated muscle degeneration that results due to this injury presents a significant clinical burden. The prevention or recovery from this degeneration requires the synchronized behavior of many cells that participate in regeneration. Strategies that tune the inflammatory cascade that is initiated after injury serves as a powerful way to influence tissue repair. Here, we use the local, sustained delivery of the immunomodulatory small molecule FTY720 to examine whether the recruitment of pro-regenerative myeloid cells affects the healing outcome...
2018: MRS Advances
https://www.readbyqxmd.com/read/30002152/exome-chip-analysis-identifies-low-frequency-and-rare-variants-in-mrpl38-for-white-matter-hyperintensities-on-brain-magnetic-resonance-imaging
#12
Xueqiu Jian, Claudia L Satizabal, Albert V Smith, Katharina Wittfeld, Joshua C Bis, Jennifer A Smith, Fang-Chi Hsu, Kwangsik Nho, Edith Hofer, Saskia P Hagenaars, Paul A Nyquist, Aniket Mishra, Hieab H H Adams, Shuo Li, Alexander Teumer, Wei Zhao, Barry I Freedman, Yasaman Saba, Lisa R Yanek, Ganesh Chauhan, Mark A van Buchem, Mary Cushman, Natalie A Royle, R Nick Bryan, Wiro J Niessen, Beverly G Windham, Anita L DeStefano, Mohamad Habes, Susan R Heckbert, Nicholette D Palmer, Cora E Lewis, Gudny Eiriksdottir, Pauline Maillard, Rasika A Mathias, Georg Homuth, Maria Del C Valdés-Hernández, Jasmin Divers, Alexa S Beiser, Sönke Langner, Kenneth M Rice, Mark E Bastin, Qiong Yang, Joseph A Maldjian, John M Starr, Stephen Sidney, Shannon L Risacher, André G Uitterlinden, Vilmundur G Gudnason, Matthias Nauck, Jerome I Rotter, Pamela J Schreiner, Eric Boerwinkle, Cornelia M van Duijn, Bernard Mazoyer, Bettina von Sarnowski, Rebecca F Gottesman, Daniel Levy, Sigurdur Sigurdsson, Meike W Vernooij, Stephen T Turner, Reinhold Schmidt, Joanna M Wardlaw, Bruce M Psaty, Thomas H Mosley, Charles S DeCarli, Andrew J Saykin, Donald W Bowden, Diane M Becker, Ian J Deary, Helena Schmidt, Sharon L R Kardia, M Arfan Ikram, Stéphanie Debette, Hans J Grabe, W T Longstreth, Sudha Seshadri, Lenore J Launer, Myriam Fornage
BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) on brain magnetic resonance imaging are typical signs of cerebral small vessel disease and may indicate various preclinical, age-related neurological disorders, such as stroke. Though WMH are highly heritable, known common variants explain a small proportion of the WMH variance. The contribution of low-frequency/rare coding variants to WMH burden has not been explored. METHODS: In the discovery sample we recruited 20 719 stroke/dementia-free adults from 13 population-based cohort studies within the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, among which 17 790 were of European ancestry and 2929 of African ancestry...
July 12, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/30002014/comparison-at-the-first-prenatal-visit-of-the-maternal-dietary-intakes-of-smokers-with-non-smokers-in-a-large-maternity-hospital-a-cross-sectional-study
#13
Eimer G O'Malley, Shona Cawley, Ciara M E Reynolds, Rachel A K Kennedy, Anne Molloy, Michael J Turner
OBJECTIVES: Using detailed dietary and supplement questionnaires in early pregnancy, we compared the dietary intakes of micronutrients and macronutrients at the first prenatal visit of women who reported continuing to smoke during pregnancy with the intakes of women who were non-smokers. DESIGN: Cross-sectional study conducted between June 2014 and March 2016. SETTING: Stand-alone tertiary maternity hospital in an urban setting with approximately 8000 deliveries per year...
July 12, 2018: BMJ Open
https://www.readbyqxmd.com/read/30001761/marital-status-and-problem-gambling-among-older-adults-an-examination-of-social-context-and-social-motivations
#14
Tara Elton-Marshall, Rochelle Wijesingha, Taryn Sendzik, Steven E Mock, Mark van der Maas, John McCready, Robert E Mann, Nigel E Turner
ABSTRACTOlder adults represent the highest proportion of gamblers (Ontario Lottery and Gaming Corporation [OLG], 2012). Unpartnered older adults may be more socially isolated and lonely (Dykstra & de Jong Gierveld, 2004), thus more likely to be at risk for problem gambling (McQuade & Gill, 2012). We examined whether gambling to socialize or from loneliness and going to the casino with friends/family mediate the relation between marital status and problem gambling. Data from a random sample of older adults at gambling venues across Southwestern Ontario indicated that gambling with family/friends and gambling due to loneliness mediated the relationship between marital status and problem gambling...
July 13, 2018: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/29999576/self-medication-with-alcohol-or-drugs-for-mood-and-anxiety-disorders-a-narrative-review-of-the-epidemiological-literature
#15
REVIEW
Sarah Turner, Natalie Mota, James Bolton, Jitender Sareen
BACKGROUND: The comorbidity of mood and anxiety disorders (MD and AD) with substance use disorders (SUD) is common. One explanation for this comorbidity is the self-medication hypothesis, which posits that individuals with MD or AD use substances to cope with the difficult symptoms associated with the disorder. Over time, self-medication (SM) can develop into an independent SUD. This narrative review will present the prevalence and correlates of SM with alcohol and/or drugs for MD and AD and the relationship between SM and subsequent SUD using both cross-sectional and longitudinal epidemiological data...
July 12, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29999553/covalency-and-ionicity-do-not-oppose-each-other-relationship-between-si-o-bond-character-and-basicity-of-siloxanes
#16
Malte Fugel, Maxie F Hesse, Rumpa Pal, Jens Beckmann, Dylan Jayatilaka, Michael J Turner, Amir Karton, Patrick Bultinck, Graham S Chandler, Simon Grabowsky
Covalency and ionicity are orthogonal rather than antipodal concepts. We demonstrate for the case of siloxane systems that both covalency and ionicity of the Si-O bonds impact on the basicity of the Si-O-Si linkage. The relationship between the siloxane basicity and the Si-O bond character has been under debate: It has been shown with natural-bond-orbital methods that increased hyperconjugative interactions, i.e. increased orbital overlap and hence covalency, are responsible for the low siloxane basicity at large Si-O-Si angles...
July 12, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29999351/gold-medal-award-for-life-achievement-in-the-science-of-psychology-constance-l-hammen
#17
(no author information available yet)
The American Psychological Foundation (APF) Gold Medal Awards recognize distinguished and engaging records of accomplishment in 4 areas of psychology. The 2018 recipient of the Gold Medal Award for Life Achievement in the Science of Psychology is Constance L. Hammen, PhD. Terence M. Keane, PhD, president of the APF, will present the APF Gold Medal Awards at the 126th Annual Convention of the American Psychological Association on August 10, 2018, at 4:00 p.m. Members of the 2018 APF Board of Trustees are Terence M...
July 2018: American Psychologist
https://www.readbyqxmd.com/read/29999350/charles-l-brewer-award-for-distinguished-teaching-of-psychology-stephen-l-chew
#18
(no author information available yet)
The American Psychological Foundation (APF) Charles L. Brewer Award for Distinguished Teaching of Psychology recognizes exemplary career contributions to the teaching of psychology. The 2018 recipient of the Charles L. Brewer Award for Distinguished Teaching of Psychology is Stephen L. Chew, PhD. Terence M. Keane, PhD, president of the APF, will present the APF Charles L. Brewer Award for Distinguished Teaching of Psychology at the 126th Annual Convention of the American Psychological Association on August 10, 2018, at 4:00 p...
July 2018: American Psychologist
https://www.readbyqxmd.com/read/29999349/gold-medal-award-for-life-achievement-in-psychology-in-the-public-interest-james-m-jones
#19
(no author information available yet)
The American Psychological Foundation (APF) Gold Medal Awards recognize distinguished and engaging records of accomplishment in 4 areas of psychology. The 2018 recipient of the Gold Medal Award for Life Achievement in Psychology in the Public Interest is James M. Jones, PhD. The president of the APF, Terence M. Keane, PhD, will present the APF Gold Medal Awards at the 126th Annual Convention of the American Psychological Association on August 10, 2018, at 4:00 p.m. Members of the 2018 APF Board of Trustees are Terence M...
July 2018: American Psychologist
https://www.readbyqxmd.com/read/29999348/gold-medal-award-for-life-achievement-in-the-practice-of-psychology-david-h-barlow
#20
(no author information available yet)
The American Psychological Foundation (APF) Gold Medal Awards recognize distinguished and engaging records of accomplishment in 4 areas of psychology. The 2018 recipient of the Gold Medal Award for Life Achievement in the Practice of Psychology is David H. Barlow, PhD, ABPP. President of the APF, Terence M. Keane, will present the APF Gold Medal Awards at the 126th Annual Convention of the American Psychological Association on August 10, 2018, at 4:00 p.m. Members of the 2018 APF Board of Trustees are Terence M...
July 2018: American Psychologist
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