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https://www.readbyqxmd.com/read/28199377/oncological-and-surgical-outcome-after-treatment-of-pelvic-sarcomas
#1
Stephan E Puchner, Philipp T Funovics, Christoph Böhler, Alexandra Kaider, Christoph Stihsen, Gerhard M Hobusch, Joannis Panotopoulos, Reinhard Windhager
BACKGROUND AND OBJECTIVES: Treatment of pelvic tumors remains challenging due to complex anatomy, poor oncological outcome and high complication rates. We sought to investigate the long-term oncological and surgical outcome of these patients. METHODS: Between 1980 and 2012, 147 patients underwent surgical treatment for pelvic sarcoma. Histological diagnosis was Chondrosarcoma in 54, Ewing's Sarcoma/PNET in 37, Osterosarcoma in 32 and others in 24 patients. Statistical analysis for the evaluation of oncological and surgical outcome was performed by applying Cox proportional hazards regression and Fine-Gray regression models for competing risk (CR) endpoints...
2017: PloS One
https://www.readbyqxmd.com/read/28196946/individualised-risk-assessment-for-local-recurrence-and-distant-metastases-in-a-retrospective-transatlantic-cohort-of-687-patients-with-high-grade-soft-tissue-sarcomas-of-the-extremities-a-multistate-model
#2
Julie J Willeumier, Anja J Rueten-Budde, Lee M Jeys, Minna Laitinen, Rob Pollock, Will Aston, P D Sander Dijkstra, Peter C Ferguson, Anthony M Griffin, Jay S Wunder, Marta Fiocco, Michiel A J van de Sande
OBJECTIVES: This study investigates the effect of surgical margins and radiotherapy, in the presence of individual baseline characteristics, on survival in a large population of high-grade soft tissue sarcoma of the extremities using a multistate model. DESIGN: A retrospective multicentre cohort study. SETTING: 4 tertiary referral centres for orthopaedic oncology. PARTICIPANTS: 687 patients with primary, non-disseminated, high-grade sarcoma only, receiving surgical treatment with curative intent between 2000 and 2010 were included...
February 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28195881/comparison-of-the-ajcc-msts-and-modified-spanier-systems-for-clinical-and-pathologic-staging-of-osteosarcoma
#3
Justin M M Cates
The prognostic performance of the 2 most commonly used staging systems for skeletal sarcoma (the American Joint Committee on Cancer [AJCC] and Musculoskeletal Tumor Society [MSTS] systems) have never been compared analytically. Another staging system originally proposed by Spanier has not yet been validated. Given the recent release of the 8th edition of the AJCC Cancer Staging Manual, this study was designed to directly compare these anatomic staging systems in a series of 153 high-grade, intramedullary osteosarcomas...
March 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28188703/the-effect-of-radiation-therapy-in-the-treatment-of-adult-soft-tissue-sarcomas-of-the-extremities-a-long-term-community-based-cancer-center-experience
#4
Jeffrey S Kneisl, Chad Ferguson, Myra Robinson, Anthony Crimaldi, Will Ahrens, James Symanowski, Michael Bates, Jennifer L Ersek, Michael Livingston, Joshua Patt, Edward S Kim
The aim of the study was to determine the effect of external beam radiotherapy (RT) in the treatment of extremity soft tissue sarcoma (STS) before or after limb-sparing surgery (LSS) in a community-based setting. Patients presenting to our institution from 1992 to 2010 and meeting eligibility criteria were stratified into low (G1) or high (G2, G3) pathologic grade and evaluated. Major complication events, including amputation, radiation-induced sarcoma, and pathologic fracture, were assessed. Kaplan-Meier techniques and Cox proportional hazards regression models were used...
February 11, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28182790/analysis-of-pulmonary-nodules-in-patients-with-high-grade-soft-tissue-sarcomas
#5
Tomoki Nakamura, Akihiko Matsumine, Miki Matsusaka, Keitaro Mizumoto, Mayuko Mori, Tomoya Yoshizaki, Takao Matsubara, Kunihiro Asanuma, Akihiro Sudo
Nowadays, small pulmonary nodules are easily detectable in patients with soft tissue sarcomas (STSs) because of highly improved computed tomography (CT) technologies. The purpose of this study was to determine the frequency and significance of the pulmonary nodules detected by CT in high-grade STS patients. 124 patients with high-grade STS were retrospectively reviewed. There were 72 males (57%) and 52 females (43%). Patients' average age was 61 years (median (quartiles) 66 years (48-75), range 8-94 years)...
2017: PloS One
https://www.readbyqxmd.com/read/28178131/prognostic-value-of-18f-fdg-pet-ct-based-functional-parameters-in-patients-with-soft-tissue-sarcoma-a-meta-analysis
#6
Linyan Chen, Xin Wu, Xuelei Ma, Linghong Guo, Chenjing Zhu, Qingfang Li
BACKGROUND: Considering the clinical importance of high 5-year mortality, we performed a meta-analysis of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) from F-FDG PET-CT for overall survival (OS) and progression-free survival (PFS) in patients with soft tissue sarcoma. METHODS: The search and selection of eligible articles was conducted on PubMed and EMBASE. We applied hazard ratio (HR) and odd ratio (OR) to measure the correlation between SUVmax, MTV, and TLG with PFS and OS...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28176365/high-efficacy-of-pazopanib-on-an-undifferentiated-spindle-cell-sarcoma-resistant-to-first-line-therapy-is-identified-with-a-patient-derived-orthotopic-xenograft-pdox-nude-mouse-model
#7
Kentaro Igarashi, Kei Kawaguchi, Takashi Murakami, Tasuku Kiyuna, Kentaro Miyake, Arun S Singh, Scott D Nelson, Sarah Dry, Yunfeng Li, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Fritz C Eilber, Robert M Hoffman
Undifferentiated spindle-cell sarcoma (USCS) is a recalcitrant cancer. Our laboratory pioneered the patient-derived orthotopic xenograft (PDOX) nude mouse model with the technique of surgical orthotopic implantation (SOI). In the present study, we evaluated the efficacy of standard first-line chemistry of doxorubicin (DOX), gemcitabine (GEM) combined with docetaxel (DOC), compared to pazopanib (PAZ), a multi-targeting tyrosine-kinase inhibitor, in an USCS PDOX model. A high-grade USCS from a striated muscle of the patients was grown orthotopically in the right biceps femoris muscle of nude mice to establish the PDOX model...
February 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28174295/optimizing-local-control-in-high-grade-uterine-sarcoma-adjuvant-vaginal-vault-brachytherapy-as-part-of-a-multimodal-treatment
#8
Pierre Annede, Sébastien Gouy, Renaud Mazeron, Enrica Bentivegna, Pierre Maroun, Claire Petit, Isabelle Dumas, Alexandra Leary, Catherine Genestie, Catherine Lhommé, Eric Deutsch, Philippe Morice, Patricia Pautier, Christine Haie-Meder, Cyrus Chargari
PURPOSE: The phase III European Organization for Research and Treatment of Cancer 55874 study has shown that external beam radiotherapy (EBRT) given as adjuvant treatment decreased locoregional recurrences from 40% to 20% in patients (pts) with localized uterine sarcomas (US). No data exist, however, on the place of brachytherapy (BT). MATERIAL AND METHODS: We conducted a single-center retrospective analysis of pts receiving adjuvant BT of the vaginal vault based on the vaginal mold technique as part of their multimodal adjuvant treatment for a high-grade US from 1985 to 2015...
February 7, 2017: Oncologist
https://www.readbyqxmd.com/read/28168937/outcomes-of-spatially-fractionated-radiotherapy-grid-for-bulky-soft-tissue-sarcomas-in-a-large-animal-model
#9
Michael W Nolan, Tracy L Gieger, Alexander A Karakashian, Mariana N Nikolova-Karakashian, Lysa P Posner, Donald M Roback, Judith N Rivera, Sha Chang
GRID directs alternating regions of high- and low-dose radiation at tumors. A large animal model mimicking the geometries of human treatments is needed to complement existing rodent systems (eg, microbeam) and clarify the physical and biological attributes of GRID. A pilot study was undertaken in pet dogs with spontaneous soft tissue sarcomas to characterize responses to GRID. Subjects were treated with either 20 Gy (3 dogs) or 25 Gy (3 dogs), delivered using 6 MV X-rays and a commercial GRID collimator. Acute toxicity and tumor responses were assessed 2, 4, and 6 weeks later...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28152173/post-relapse-outcomes-after-primary-extended-resection-of-retroperitoneal-sarcoma-a-report-from-the-trans-atlantic-rps-working-group
#10
Andrea J MacNeill, Rosalba Miceli, Dirk C Strauss, Sylvie Bonvalot, Peter Hohenberger, Frits Van Coevorden, Piotr Rutkowski, Dario Callegaro, Andrew J Hayes, Charles Honoré, Mark Fairweather, Amanda Cannell, Jens Jakob, Rick L Haas, Milena Szacht, Marco Fiore, Paolo G Casali, Raphael E Pollock, Chandrajit P Raut, Alessandro Gronchi, Carol J Swallow
BACKGROUND: Despite a radical surgical approach to primary retroperitoneal sarcoma (RPS), many patients experience locoregional and/or distant recurrence. The objective of this study was to analyze post-relapse outcomes for patients with RPS who had initially undergone surgical resection of their primary tumor at a specialist center. METHODS: All consecutive patients who underwent macroscopically complete resection for primary RPS at 8 high volume centers from January 2002 to December 2011 were identified, and those who developed local recurrence (LR) only, distant metastasis (DM) only, or synchronous local recurrence and distant metastasis (LR+DM) during the follow-up period were included...
February 2, 2017: Cancer
https://www.readbyqxmd.com/read/28145936/a-rare-case-of-malignant-fibrous-histiocytoma-undifferentiated-high-grade-pleomorphic-sarcoma-of-malar-region
#11
Éder A Sigua-Rodriguez, Douglas Rangel Goulart, Afonso Celso de Moraes Manzano, Luciana Asprino
Malignant fibrous histiocytoma is a sarcoma with rare occurrence in the oral and maxillofacial region; surgery is the most reliable treatment. Inadequate resection of the sarcoma on the oral and maxillofacial region is associated with a high incidence of local recurrence and a poor prognosis. Only few patients of malignant fibrous histiocytoma of the malar region have been previously reported in the literature. The authors report a new patient of malignant fibrous histiocytoma on the right malar region that treated a complete tumor surgical excision without lymph node dissection...
January 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28134693/spindle-cell-sarcoma-of-the-iliac-vein-on-18f-fdg-pet-ct
#12
Chung-Shin Bek, Hae Won Kim, Kyoung Sook Won, Bong-Il Song
A 44-year-old woman with a protruding mass of the right thigh underwent an F-FDG PET/CT and gadolinium-enhanced MRI. The F-FDG PET/CT scan revealed mildly increased F-FDG uptake in a large mass involving the right common and external iliac veins. The gadolinium-enhanced MRI revealed a well-enhancing soft tissue mass inside the right common and external iliac veins. The mass was diagnosed as high-grade spindle cell sarcoma with fibroblastic differentiation.
January 27, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28133880/intra-and-inter-observer-agreement-in-histological-assessment-of-canine-soft-tissue-sarcoma
#13
F W Yap, R Rasotto, S L Priestnall, K J Parsons, J Stewart
BACKGROUND: The diagnosis of canine soft tissue sarcoma (STS) is based on histological assessment. Assessment of criteria such as, degree of differentiation, necrosis score and mitotic score, gives rise to a final tumour grade, which is important in the recommendation of treatment and prognosis of patients. MATERIALS AND METHODS: Previously diagnosed cases of STS were independently assessed by three board-certified veterinary pathologists. Participating pathologists were blinded to the original results...
January 30, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28127762/improved-local-control-with-an-aggressive-strategy-of-preoperative-with-or-without-intraoperative-radiation-therapy-combined-with-radical-surgical-resection-for-retroperitoneal-sarcoma
#14
Melissa A Hull, George Molina, Andrzej Niemierko, Alex B Haynes, Alex Jacobson, Karen De Amorim Bernstein, Yen-Lin Chen, Thomas F DeLaney, John T Mullen
BACKGROUND AND OBJECTIVES: We sought to examine our outcomes with advanced preoperative and intraoperative radiation therapy (XRT) combined with aggressive en bloc surgical resection of retroperitoneal sarcoma (RPS) as a strategy to minimize the risk of local recurrence (LR). METHODS: From 2003 to 2013, 46 patients with RPS received preoperative XRT followed by radical en bloc surgical resection, with or without intraoperative electron radiation therapy (IOERT)...
January 27, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28127434/pulmonary-cryptococcosis-mimicking-a-metastasis-in-a-patient-with-ewing-sarcoma
#15
Akio Sakamoto, Masanori Hisaoka
Cryptococcosis is an invasive fungal infection that is common in immunocompromised patients. A 22-year-old woman with Ewing sarcoma in the right proximal humerus was treated by resection and chemotherapy. Computed tomography detected a small nodule in her right upper pulmonary lobe after completion of her chemotherapy. With the presumptive diagnosis of pulmonary metastasis, she underwent resection. Evaluation of the resected specimen revealed pulmonary cryptococcosis, and the patient was treated with oral fluconazole for 18 weeks...
September 2016: Respirology Case Reports
https://www.readbyqxmd.com/read/28126006/significant-benefits-in-survival-by-the-use-of-surgery-combined-with-radiotherapy-for-retroperitoneal-soft-tissue-sarcoma
#16
Sven Hager, Frank Makowiec, Karl Henne, Ulrich T Hopt, Uwe A Wittel
BACKGROUND: To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-term prognosis. METHODS: In 53 patients who underwent surgery for retroperitoneal soft tissue sarcoma (RSTS) from 2001 to 2014 prognostic and epidemiologic factors were reviewed retrospectively to analyze their impact on survival and recurrence. RESULTS: Twenty three patients (50%) had surgery plus radiotherapy, 23 (50%) had surgery only...
January 26, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28122321/soft-tissue-mesenchymal-tumour-a-case-report-with-review-of-literature
#17
Debkumar Chowdhury, Michal Chudy, Sanjeet Bhattacharya
INTRODUCTION: Soft tissue mesenchymal tumours are a common occurrence in surgical practice with particular predilection for the extremities. Approximately 1 in 100 soft tissue tumours are found to be sarcomas. The main concern is to exclude any evidence of malignancy. Both imaging studies and a detailed histological analysis is required to ensure that a diagnosis of a high-grade tumour is not missed. PRESENTATION OF CASE: Here we present a 38-year-old previously fit and well gentleman with a slowly growing lump in the upper aspect of his abdomen over the previous year being completely asymptomatic from it...
January 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28116485/somatic-leiomyosarcoma-of-the-soft-tissues-a-single-institutional-analysis-of-factors-predictive-of-survival-in-164-patients
#18
Kamran Harati, Adrien Daigeler, Kim Lange, Hiltrud Niggemann, Ingo Stricker, Hans-Ulrich Steinau, Marcus Lehnhardt, Ole Goertz
BACKGROUND: Somatic leiomyosarcoma (LMS) is an aggressive soft tissue sarcoma entity with a high metastatic potential. The purpose of this study was to identify prognostic indicators of survival in patients with somatic LMS of the soft tissues. METHODS: We retrospectively assessed the relationship between local recurrence-free survival (LRFS), disease-specific survival (DSS), overall survival (OS) and potential prognostic factors in 164 patients who were suitable for surgical treatment in curative intent...
January 23, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28114189/androgen-receptor-expression-in-endometrial-stromal-sarcoma-correlation-with-clinicopathologic-features
#19
Maitrayee Roy, Sunesh Kumar, Neerja Bhatla, Mukurdipi D Ray, Lalit Kumar, Deepali Jain, Ravi Phulware, Sandeep R Mathur
Endometrial stromal sarcoma (ESS) is a rare neoplasm comprising only 0.2% to 1% of all uterine malignancies and afflicts women between 42 and 59 yr of age. ESSs frequently express estrogen receptor (ER) and progesterone receptor (PR). However, the published literature contains scant data on the expression and therapeutic/prognostic role of androgen receptor (AR) in ESSs. We undertook this study to characterize the expression of AR along with ER and PR in ESSs and correlate it with clinicopathologic features...
January 20, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28109463/head-and-neck-sarcomas-a-single-institute-series
#20
Leandros-Vassilios Vassiliou, Bagrat Lalabekyan, Amrita Jay, Colin Liew, Jeremy Whelan, Laurence Newman, Nicholas Kalavrezos
BACKGROUND: Sarcomas are tumours of mesenchymal origin, accounting for 1% of all malignancies. METHODS: This is a retrospective analysis of 107 head and neck sarcoma cases, treated over a period of thirteen years. RESULTS: Fifty-four patients had with craniofacial bone sarcomas (BSs) (male: 33; female: 21) with high grade osteosarcoma being the most predominant type. The soft tissue sarcomas (STS) (53 patients; male: 28, female: 25) were histologically diverse with rhabdomyosarcomas and myxofibrosarcomas being the predominant types...
February 2017: Oral Oncology
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