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Corneal refractive therapy

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https://www.readbyqxmd.com/read/28576215/effect-of-dry-eye-on-scheimpflug-imaging-of-the-cornea-and-elevation-data
#1
Leyla Asena, Dilek D Altınörs, Şefik Cezairlioğlu, Sefer Ogün Bölük
OBJECTIVE: To evaluate the effect of dry eye on Scheimpflug imaging of the cornea and elevation data. DESIGN: Prospective observational study. PARTICIPANTS: Scheimpflug images of 50 patients with dry eye who were being tested for eligibility for corneal refractive surgery were screened. Twelve eyes of 12 patients with abnormal Belin/Ambrosio enhanced ectasia display (BAD) anterior elevation difference were included in the study. The patients had no history of contact lens wear or any other sign of ectasia...
June 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28559836/unilateral-posterior-polymorphous-corneal-dystrophy-presented-as-anisometropic-astigmatism-3-case-reports
#2
Hyun Sun Jeon, Joon Young Hyon
BACKGROUND: Posterior polymorphous corneal dystrophy (PPCD) is typically considered bilateral and asymptomatic. However, few case reports on patients with unilateral PPCD with asymmetric refractive error have mentioned anisometropic amblyopia development. In support of this, we report 3 cases of unilateral PPCD that presented as anisometropic astigmatism. Visual prognosis related to amblyopia development is discussed. CASE PRESENTATION: All 3 patients had a band lesion in the affected eye and a difference of at least 1...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28546941/role-of-corneal-collagen-fibrils-in-corneal-disorders-and-related-pathological-conditions
#3
REVIEW
Hong-Yan Zhou, Yan Cao, Jie Wu, Wen-Song Zhang
The cornea is a soft tissue located at the front of the eye with the principal function of transmitting and refracting light rays to precisely sense visual information. Corneal shape, refraction, and stromal stiffness are to a large part determined by corneal fibrils, the arrangements of which define the corneal cells and their functional behaviour. However, the modality and alignment of native corneal collagen lamellae are altered in various corneal pathological states such as infection, injury, keratoconus, corneal scar formation, and keratoprosthesis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28486314/cellular-therapy-with-human-autologous-adipose-derived-adult-stem-cells-for-advanced-keratoconus
#4
Jorge L Alió Del Barrio, Mona El Zarif, María P de Miguel, Albert Azaar, Norman Makdissy, Walid Harb, Ibrahim El Achkar, Francisco Arnalich, Jorge L Alió
PURPOSE: The aim of this phase 1 study was to preliminarily evaluate the safety and efficacy of autologous adipose-derived adult stem cell (ADASC) implantation within the corneal stroma of patients with advanced keratoconus. METHODS: Five consecutive patients were selected. Autologous ADASCs were obtained by elective liposuction. ADASCs (3 × 10) contained in 1 mL saline were injected into the corneal stroma through a femtosecond-assisted 9.5-mm diameter lamellar pocket under topical anesthesia...
May 8, 2017: Cornea
https://www.readbyqxmd.com/read/28456063/ocular-findings-in-adult-subjects-with-an-inactivating-mutation-in-gh-releasing-hormone-receptor-gene
#5
Augusto C N Faro, Virginia M Pereira-Gurgel, Roberto Salvatori, Viviane C Campos, Gustavo B Melo, Francielle T Oliveira, Alecia A Oliveira-Santos, Carla R P Oliveira, Francisco A Pereira, Ann Hellström, Luís A Oliveira-Neto, Eugenia H O Valença, Manuel H Aguiar-Oliveira
OBJECTIVE: Ocular function is fundamental for environmental adaptation and survival capacity. Growth factors are necessary for a mature eyeball, needed for adequate vision. However, the consequences of the deficiency of circulating growth hormone (GH) and its effector insulin-like growth factor I (IGF-I) on the physical aspects of the human eye are still debated. A model of untreated isolated GH deficiency (IGHD), with low but measurable serum GH, may clarify this issue. The aim of this study was to assess the ocular aspects of adult IGHD individuals who have never received GH therapy...
June 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28445315/the-effect-of-timolol-0-5-on-the-correction-of-myopic-regression-after-lasik
#6
RANDOMIZED CONTROLLED TRIAL
Hong Qi, Caifeng Gao, Yaxin Li, Xue Feng, Miao Wang, Yu Zhang, Yueguo Chen
BACKGROUD: Postlaser in situ keratomileusis (post-LASIK) refractive regression is defined as the gradual, partial, or total loss of initial correction that limits the predictability, efficiency, and long-term stability of LASIK. Our study assesses the effect of Timolol 0.5% on the correction of myopic regression after LASIK. METHODS: This prospective, randomized, controlled study included 62 eyes of 62 patients with myopic regression of -1.18 ± 0.86 diopters (D) after myopic LASIK...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28404521/diabetic-complications-in-the-cornea
#7
Alexander V Ljubimov
Diabetic corneal alterations, such as delayed epithelial wound healing, edema, recurrent erosions, neuropathy/loss of sensitivity, and tear film changes are frequent but underdiagnosed complications of both type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus. The disease affects corneal epithelium, corneal nerves, tear film, and to a lesser extent, endothelium, and also conjunctiva. These abnormalities may appear or become exacerbated following trauma, as well as various surgeries including retinal, cataract or refractive...
April 28, 2017: Vision Research
https://www.readbyqxmd.com/read/28264130/a-new-matrix-therapy-agent-for-faster-corneal-healing-and-less-ocular-discomfort-following-epi-off-accelerated-corneal-cross-linking-in-progressive-keratoconus
#8
Koray Gumus, Marta Gomes Guerra, Sara Homem de Melo Marques, Sarper Karaküçük, Denis Barritault
PURPOSE: To investigate the hypothesis that a new matrix therapy agent (ReGeneraTing Agent, [RGTA]) would speed up the corneal reepithelialization, improve stromal healing, and reduce ocular symptoms after epi-off corneal cross-linking (CXL). METHODS: Sixty eyes of 60 patients with progressive keratoconus were enrolled in the study. Epi-off accelerated CXL was performed in all patients. Sixty eyes were randomized into two groups according to use of RGTA eye drops prior to contact lens fitting at the end...
March 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28068444/effectiveness-of-an-eyelid-thermal-pulsation-procedure-to-treat-recalcitrant-dry-eye-symptoms-after-laser-vision-correction
#9
Craig S Schallhorn, Julie M Schallhorn, Stephen Hannan, Steven C Schallhorn
PURPOSE: To provide an initial retrospective evaluation of the effectiveness of a thermal pulsation system to treat intractable patient-reported dye eye symptoms following laser vision correction. METHODS: A total of 109 eyes of 57 patients underwent thermal pulsation therapy (LipiFlow; TearScience, Morrisville, NC) for the treatment of dry eye symptoms following laser vision correction. A standardized dry eye questionnaire, the Standard Patient Evaluation of Eye Dryness (SPEED II), was administered to all patients before and after thermal pulsation therapy...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28009792/clinical-features-in-children-with-posterior-polymorphous-corneal-dystrophy
#10
Ye Jin Ahn, Soon Il Choi, Hae Ri Yum, Sun Young Shin, Shin Hae Park
PURPOSE: To describe clinical features in children diagnosed with posterior polymorphous corneal dystrophy (PPCD) in their first or second decade of life. METHODS: A retrospective study was performed with the medical records of seven unrelated Korean pediatric patients who were diagnosed with PPCD and were followed up for a minimum of 3 years. Thorough ocular examinations were performed, including best-corrected visual acuity, intraocular pressure, refractive and keratometric measurements, slit-lamp biomicroscopy, and specular microscopy at all visits...
December 22, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28003981/phakic-posterior-chamber-intraocular-lens-for-unilateral-high-myopic-amblyopia-in-chinese-pediatric-patients
#11
Jing Zhang, Jin-Rong Li, Zi-Dong Chen, Min-Bin Yu, Ke-Ming Yu
AIM: To assess the outcomes of posterior chamber implantable collamer lens (ICL) implantation in Chinese pediatric patients with unilateral high myopic amblyopia. METHODS: Eleven eyes of 11 amblyopic patients aged 11.02±3.34y underwent ICL (model V4, Staar Surgical Inc.) implantation to treat unilateral anisometropia were studied. Visual acuity, cycloplegic refraction, contrast sensitivity, stereopsis, intraocular pressure (IOP), vaulting, corneal endothelial cell count and complications were evaluated...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27926756/cutting-and-decellularization-of-multiple-corneal-stromal-lamellae-for-the-bioengineering-of-endothelial-grafts
#12
Zhiguo He, Fabien Forest, Aurélien Bernard, Anne-Sophie Gauthier, Romain Montard, Michel Peoc'h, Clotilde Jumelle, Emilie Courrier, Chantal Perrache, Philippe Gain, Gilles Thuret
Purpose: Engineered corneal endothelial grafts able to provide numerous functional endothelial cells for the restoration of corneal transparency would be a worthwhile way of replacing donor tissue, which is extremely scarce. The grafts are simply constructed: a biocompatible thin and transparent carrier colonized by a monolayer of cultured endothelial cells (ECs). Here we describe a process able to obtain appropriate carriers by recycling human corneas unsuitable for graft in their original state, but liable to provide multiple thin lamellae when cut with a femtosecond laser as used in refractive surgery...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27904945/-sarcoidosis-and-uveitis-an-update
#13
REVIEW
J G Garweg
Ocular involvement in sarcoidosis is present in up to one third of patients and is frequently manifested before the underlying systemic disease has been diagnosed. With a view to the therapeutic consequences an early diagnosis of the underlying disease is advantageous. In cases of visual loss early diagnostic measures include invasive procedures, such as ultrasound-guided bronchoalveolar lavage and transbronchial biopsy, if nodular conjunctival or cutaneous manifestations which would confirm the diagnosis are not present...
November 30, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27873014/binocular-function-changes-produced-in-response-to-overnight-orthokeratology
#14
Gema Felipe-Marquez, María Nombela-Palomo, Catalina Palomo-Álvarez, Isabel Cacho, Amelia Nieto-Bona
PURPOSE: To analyze the binocular function changes produced on subjects undergoing overnight orthokeratology (OK) treatment over short-term (3 months) and long-term (3 years) wear. METHODS: A prospective, longitudinal study on young adult subjects with low to moderate myopia was carried out. Binocular function was assessed by the following sequence of tests: Distance and near horizontal phoria (Von Graefe technique), distance and near horizontal vergence ranges (Risley rotary prisms), accommodative convergence/accommodation (AC/A) ratio (gradient method) and the near point of convergence (standard push-up technique)...
January 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27684823/clinical-evaluation-of-deep-anterior-lamellar-keratoplasty-using-glycerol-cryopreserved-corneal-tissues-for-refractory-herpetic-stromal-keratitis-an-observational-study
#15
Xin Liu, Qi Zhou, Xinyu Huang, Zhenxing Liu, Yanlong Bi
The study aimed to evaluate the therapeutic effects of deep anterior lamellar keratoplasty (DALK) using glycerol-cryopreserved corneal tissues (GCCTs) in patients with refractive herpes simplex keratitis (HSK). This article was a retrospective, noncomparative, and interventional case series. Patients with HSK underwent DALK using GCCTs at Shanghai Tongji Hospital from 2012 to 2015. The best spectacle corrected visual acuity, recurrent inflammation, graft status, postoperative central graft thickness, and pre/postoperative complications were detected...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27456563/-riboflavin-photoprotection-with-cross-linking-effect-in-photorefractive-ablation-of-the-cornea
#16
I M Kornilovskiy, A I Sultanova, A A Burtsev
UNLABELLED: Photorefractive ablation is inevitably accompanied by oxidative stress of the cornea and weakening of its biomechanical and photoprotective properties. AIM: To validate the expediency of riboflavin use in photorefractive ablation for photoprotection of the cornea and cross-linking. MATERIAL AND METHODS: The effects of riboflavin use in photorefractive ablation was first studied in a series of in vitro and in vivo experiments performed on 56 eyes of 28 rabbits, and then on 232 eyes of 142 patients with different degrees of myopia...
May 2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27450739/thymosin-beta-4-a-potential-novel-therapy-for-neurotrophic-keratopathy-dry-eye-and-ocular-surface-diseases
#17
G Sosne, D Rimmer, H K Kleinman, G Ousler
Chronic ocular surface diseases such as dry eye, blepharitis, and neurotrophic keratopathies represent a significant and a growing therapeutic challenge. The basis of this expanding prevalence is multifactorial and may due to issues such as an aging population, an increasing use of video display terminals, and increases in frequency of refractive surgeries. The growing incidence of diseases such as diabetes may also be a contributing factor. Current treatments for ocular surface disease include artificial tears, lubricants, tear duct plugs, steroids, antibiotics, cyclosporine, scleral lenses, and serum tears...
2016: Vitamins and Hormones
https://www.readbyqxmd.com/read/27134906/evaluation-of-ocular-side-effects-in-the-patients-on-topiramate-therapy-for-control-of-migrainous-headache
#18
Omid Hesami, Seyedeh Simindokht Hosseini, Nasim Kazemi, Seyed-Mostafa Hosseini-Zijoud, Nahid Beladi Moghaddam, Farhad Assarzadegan, Sara Mokhtari, Shahrzad Fakhraee
INTRODUCTION: Topiramate, a sulfa-derivative monosaccharide, is an antiepileptic drug which is administered in the control of migraine. It is reported to cause various ocular side effects such as visual field defect and myopic shift. To investigate the alterations in refractive error, properties of the cornea and changes in the anterior chamber in patients that receive Topiramate for migraine control. MATERIALS AND METHODS: This is a hospital-based, non-interventional, observational study that is conducted at Imam Hossein Hospital, affiliated to Shahid Beheshti University of Medical Sciences, Department of Neurology, in collaboration with the department of Ophthalmology...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27051527/corneal-based-surgical-presbyopic-therapies-and-their-application-in-pseudophakic-patients
#19
REVIEW
Grace L Paley, Roy S Chuck, Linda M Tsai
Purpose. The purpose of this review is to provide a summary of laser refractive surgery and corneal inlay approaches to treat presbyopia in patients after cataract surgery. Summary. The presbyopic population is growing rapidly along with increasing demands for spectacle independence. This review will focus on the corneal-based surgical options to address presbyopia including various types of corneal intrastromal inlays and laser ablation techniques to generate either a multifocal cornea ("PresbyLASIK") or monovision...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27051478/corneal-changes-after-collagen-crosslinking-for-keratoconus-using-dual-scheimpflug-imaging
#20
Mohammad Mehdi Sadoughi, Sepehr Feizi, Siamak Delfazayebaher, Alireza Baradaran-Rafii, Bahram Einollahi, Camelia Shahabi
PURPOSE: To evaluate corneal changes after collagen crosslinking (CXL) therapy for keratoconus (KCN) using the Galilei dual Scheimpflug analyzer. METHODS: This prospective, nonrandomized clinical study included 35 eyes of 32 keratoconus patients who had undergone CXL. The eyes were saturated with riboflavin solution and were subjected for 30 minutes to ultraviolet-A (UV-A) light with irradiance of 3 mW/cm(2). Effectiveness of the treatment was assessed by measuring uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), manifest cylinder/sphere, keratometry, pachymetry, posterior and anterior elevations by the Galilei dual Scheimpflug analyzer...
October 2015: Journal of Ophthalmic & Vision Research
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