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Myopia control

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https://www.readbyqxmd.com/read/28933972/visual-acuity-and-macular-and-peripapillary-thickness-in-high-myopia
#1
Solmaz Abdolrahimzadeh, Francesco Parisi, Andrea Maria Plateroti, Federica Evangelista, Vito Fenicia, Gianluca Scuderi, Santi Maria Recupero
PURPOSE: To investigate best corrected visual acuity (BCVA), and choroidal and retinal thickness values between high myopes without myopic maculopathy and emmetropes. MATERIALS AND METHODS: Case control study where 53 myopes with axial length (AL) above 26 mm without myopic maculopathy and 53 age-matched emmetropes with AL between 21.50 and 24.50 were included as controls. Complete ophthalmological examination and biometry were performed. Choroidal and individual retinal layer thickness maps using spectral domain optical coherence tomography were obtained in the macular and peripapillary area with enhanced depth imaging...
September 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28893307/interventions-to-control-myopia-progression-in-children-protocol-for-an-overview-of-systematic-reviews-and-meta-analyses
#2
Efthymia Prousali, Asimina Mataftsi, Nikolaos Ziakas, Andreas Fontalis, Periklis Brazitikos, Anna-Bettina Haidich
BACKGROUND: Myopia is a common visual disorder with increasing prevalence among developed countries of the world. Myopia constitutes a substantial risk factor for several ocular conditions that can lead to blindness. The purpose of this study is to conduct an overview of systematic reviews and meta-analyses in order to identify and appraise robust research evidence regarding the management of myopia progression in children and adolescents. METHODS: A literature search will be conducted in MEDLINE, EMBASE, The Cochrane Database of Systematic Reviews (CDSR), Database of Abstracts of Reviews of Effects (DARE), and Health Technology Assessment (HTA) Database via Centre for Reviews and Dissemination (CRD)...
September 11, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28884119/genetic-association-study-of-kcnq5-polymorphisms-with-high-myopia
#3
Xuan Liao, Maurice K H Yap, Kim Hung Leung, Patrick Y P Kao, Long Qian Liu, Shea Ping Yip
Identification of genetic variations related to high myopia may advance our knowledge of the etiopathogenesis of refractive error. This study investigated the role of potassium channel gene (KCNQ5) polymorphisms in high myopia. We performed a case-control study of 1563 unrelated Han Chinese subjects (809 cases of high myopia and 754 emmetropic controls). Five tag single-nucleotide polymorphisms (SNPs) of KCNQ5 were genotyped, and association testing with high myopia was conducted using logistic regression analysis adjusted for sex and age to give Pasym values, and multiple comparisons were corrected by permutation test to give Pemp values...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28864176/riboflavin-and-ultraviolet-a-irradiation-for-the-prevention-of-progressive-myopia-in-a-guinea-pig-model
#4
Xiaoxia Li, Miaoqin Wu, Luyi Zhang, Hui Liu, Lan Zhang, Jinjing He
In this study, we evaluated the effect of oral administration of riboflavin combined with whole-body ultraviolet A (UVA) irradiation on the biochemical and biomechanical properties of sclera in a guinea pig model to control the progression of myopia. Experimental groups were administered 0.1% riboflavin solution with or without vitamin C by gavage from 3 days before myopic modeling and during the modeling process. Guinea pigs underwent 30 min of whole-body UVA irradiation after each gavage for 2 weeks. For control groups, guinea pigs were administered vitamin C and underwent either whole-body UVA irradiation without 0...
August 31, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28861353/role-of-short-wavelength-filtering-lenses-in-delaying-myopia-progression-and-amelioration-of-asthenopia-in-juveniles
#5
Hai-Lan Zhao, Jin Jiang, Jie Yu, Hai-Ming Xu
AIM: To evaluate the positive effects of blue-violet light filtering lenses in delaying myopia and relieving asthenopia in juveniles. METHODS: Sixty ametropia juveniles (aged range, 11-15y) were randomized into two groups: the test group (30 children, 60 eyes), wearing blue-violet light filtering lenses; and the control group (30 children, 60 eyes), wearing ordinary aspherical lenses. Baseline refractive power of the affected eyes and axial length of the two groups was recorded...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28844325/-visual-outcomes-four-years-after-small-incision-lenticule-extraction-smile-surgery-on-highly-myopic-eyes-french-version
#6
J Burazovitch, D Naguzeswski, T Beuste, M Guillard
OBJECTIVE: To determine whether the visual outcomes of the refractive surgery technique, small incision lenticule extraction (SMILE), are stable, effective, and predictable for high myopia over a four-year period. RESEARCH DESIGN: This is a retrospective study. The data were collected between March 2012 and July 2016. PARTICIPANTS: Two hundred and forty-eight patients participated in the study; that is, 496 eyes: 140 eyes of 70 patients (52 women/18 men) were classified in the highly myopic group (refraction measured in spherical equivalent [RMSE]>-6D), and 356 eyes of 178 patients (98 women/80 men) in the control group (RMSE≤-6D)...
September 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28842942/risk-factors-of-age-related-cataract-in-a-chinese-adult-population-the-taizhou-eye-study
#7
Yating Tang, Xiaofeng Wang, Jiucun Wang, Li Jin, Wei Huang, Yi Luo, Yi Lu
IMPORTANCE: Cataract risk factors data will provide epidemic evidence for cataract prevention. BACKGROUND: To study the risk factors for age-related cataract (ARC) in a Chinese adult population. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: 10,234 eligible subjects ≥45 years old (response rate 78.1%). METHODS: We conducted detailed eye examinations including presenting visual acuity (PVA), best-corrected visual acuity (BCVA), slit lamp examination of lens opacities and fundus examination...
August 25, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28820793/codeine-plus-acetaminophen-for-pain-after-photorefractive-keratectomy-a-randomized-double-blind-placebo-controlled-add-on-trial
#8
Vinicius B P Pereira, Renato Garcia, Andre A M Torricelli, Adriana Mukai, Samir J Bechara
BACKGROUND: Pain after photorefractive keratectomy (PRK) is significant, and the analgesic efficacy and safety of oral opioids in combination with acetaminophen has not been fully investigated in PRK trials. PURPOSE: To assess the efficacy and safety of the combination of codeine plus acetaminophen (paracetamol) versus placebo as an add-on therapy for pain control after PRK. STUDY DESIGN: Randomized, double-blind, placebo-controlled trial...
October 2017: Cornea
https://www.readbyqxmd.com/read/28816867/peripheral-refraction-and-aberration-profiles-with-multifocal-lenses
#9
RANDOMIZED CONTROLLED TRIAL
Cathleen Fedtke, Klaus Ehrmann, Varghese Thomas, Ravi C Bakaraju
SIGNIFICANCE: The amount of central or peripheral myopic shift, as induced by different multifocal contact lenses when viewing objects at distance or near, may provide insights on the potential efficacy for slowing eye growth. PURPOSE: The present study aims to compare peripheral refraction and higher-order aberration profiles of four multifocal contact lenses with a single vision control lens. METHODS: Thirty-five myopes (age 21.2 ± 2.1 years) completed the trial, of whom 16 wore Air Optix Aqua and Proclear Multifocal Distance and Near (Group 1, spherical equivalent: -2...
September 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28752898/contact-lenses-to-slow-progression-of-myopia
#10
REVIEW
Padmaja Sankaridurg
The prevalence of myopia has been steadily rising, with 28 per cent of the global population said to be affected in 2010 and to rise to affect nearly 50 per cent by 2050. Increasing levels of myopia increase the risk of vision impairment and in particular, high myopia is associated with the risk of serious and permanent visual disability due to associated sight-threatening complications. To stem the burden associated with higher levels of myopia, there are efforts to slow the progression of myopia, and several optical and pharmaceutical strategies have been found useful in slowing myopia to varying degrees...
July 28, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28751151/development-of-refractive-errors-what-can-we-learn-from-inherited-retinal-dystrophies
#11
Michelle Hendriks, Virginie J M Verhoeven, Gabriëlle H S Buitendijk, Jan Roelof Polling, Magda A Meester-Smoor, Albert Hofman, Maarten Kamermans, L Ingeborgh van den Born, Caroline C W Klaver
PURPOSE: It is unknown which retinal cells are involved in the retina-to-sclera signaling cascade causing myopia. As inherited retinal dystrophies (IRD) are characterized by dysfunction of a single retinal cell type and have a high risk of refractive errors, a study investigating the affected cell type, causal gene and refractive error in IRDs may provide insight herein. DESIGN: Case-control study. METHODS: Study population: 302 patients with IRD from two ophthalmogenetic centers in the Netherlands...
July 24, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28746982/myopia-progression-control-lens-reverses-induced-myopia-in-chicks
#12
Elizabeth L Irving, Cristina Yakobchuk-Stanger
PURPOSE: To determine whether lens induced myopia in chicks can be reversed or reduced by wearing myopia progression control lenses of the same nominal (central) power but different peripheral designs. METHODS: Newly hatched chicks wore -10D Conventional lenses unilaterally for 7 days. The myopic chicks were then randomly divided into three groups: one fitted with Type 1 myopia progression control lenses, the second with Type 2 myopia progression control lenses and the third continued to wear Conventional lenses for seven more days...
July 26, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28739381/role-of-parafovea-in-blur-perception
#13
Abinaya Priya Venkataraman, Aiswaryah Radhakrishnan, Carlos Dorronsoro, Linda Lundström, Susana Marcos
The blur experienced by our visual system is not uniform across the visual field. Additionally, lens designs with variable power profile such as contact lenses used in presbyopia correction and to control myopia progression create variable blur from the fovea to the periphery. The perceptual changes associated with varying blur profile across the visual field are unclear. We therefore measured the perceived neutral focus with images of different angular subtense (from 4° to 20°) and found that the amount of blur, for which focus is perceived as neutral, increases when the stimulus was extended to cover the parafovea...
September 2017: Vision Research
https://www.readbyqxmd.com/read/28737608/a-randomized-trial-of-soft-multifocal-contact-lenses-for-myopia-control-baseline-data-and-methods
#14
RANDOMIZED CONTROLLED TRIAL
Jeffrey J Walline, Amber Gaume Giannoni, Loraine T Sinnott, Moriah A Chandler, Juan Huang, Donald O Mutti, Lisa A Jones-Jordan, David A Berntsen
SIGNIFICANCE: The Bifocal Lenses In Nearsighted Kids (BLINK) study is the first soft multifocal contact lens myopia control study to compare add powers and measure peripheral refractive error in the vertical meridian, so it will provide important information about the potential mechanism of myopia control. PURPOSE: The BLINK study is a National Eye Institute-sponsored, double-masked, randomized clinical trial to investigate the effects of soft multifocal contact lenses on myopia progression...
September 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28730114/diagnostic-capability-of-peripapillary-retinal-nerve-fiber-layer-parameters-in-time-domain-versus-spectral-domain-optical-coherence-tomography-for-assessing-glaucoma-in-high-myopia
#15
Mei-Ching Teng, Yi-Chieh Poon, Kuo-Chi Hung, Hsueh-Wen Chang, Ing-Chou Lai, Jen-Chia Tsai, Pei-Wen Lin, Chien-Yun Wu, Chueh-Tan Chen, Pei-Chang Wu
AIM: To evaluate and compare the diagnostic capabilities of peripapillary retinal nerve fiber layer (p-RNFL) parameters of Spectralis optical coherence tomography (OCT) versus Stratus OCT to detect glaucoma in patients with high myopia. METHODS: This is a retrospective, cross-sectional study. Sixty highly myopic eyes of 60 patients were enrolled, with 30 eyes in the glaucoma group and 30 eyes in the control group. All eyes received peripapillary imaging of the optic disc using Stratus and Spectralis OCT...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28721004/epithelium-on-photorefractive-intrastromal-cross-linking-pixl-for-reduction-of-low-myopia
#16
Wee Kiak Lim, Zhi Da Soh, Harold Kah Yen Choi, Julian Thiam Siew Theng
PURPOSE: To report the 9-12-month outcomes of a novel procedure for reduction of low myopia through epithelium-on photorefractive intrastromal cross-linking (PiXL) with customized control of topographic distribution of ultraviolet (UV)-fluence. METHOD: Myopic patients with normal (non-ectatic) corneas underwent the PiXL procedure for reduction of low myopia. PiXL treatments were delivered through selective application of UVA light based on the refractive error of each patient...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28719538/misight-assessment-study-spain-a-comparison-of-vision-related-quality-of-life-measures-between-misight-contact-lenses-and-single-vision-spectacles
#17
Alicia Ruiz Pomeda, Belén Pérez-Sánchez, Maria Del Pilar Cañadas Suárez, Francisco Luis Prieto Garrido, Ramón Gutiérrez-Ortega, César Villa-Collar
OBJECTIVES: Recent research has shown that concentric contact lenses (CLs) can be a way to control the progression of myopia. The purpose of the current study was to compare vision-related quality-of-life measures in children wearing distance single-vision (SV) spectacles versus MiSight CLs, a specific concentric design for myopia control. METHODS: Subjects aged 8 to 12 with myopia from -0.75 to -4.00 diopters (D) of sphere and astigmatism less than 1.00 D of cylinder were allocated to the lenses study group (MiSight) or control group (SV)...
July 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28718904/autologous-serum-eye-drops-and-enhanced-epithelial-healing-time-after-photorefractive-keratectomy
#18
Hanife Tuba Akcam, Metin Unlu, Emine Esra Karaca, Hulya Yazici, Bahri Aydin, Ahmet Murad Hondur
BACKGROUND: The aim of the study is to test whether use of autologous serum eye-drops can provide earlier epithelial healing following the application of photorefractive keratectomy. METHOD: Sixty patients (60 eyes) underwent photorefractive keratectomy for myopia. Thirty eyes received autologous serum drops (Study group) while 30 eyes received conventional artificial tears (Control group) after photorefractive keratectomy. An 8 mm epithelial opening was prepared with the application of 18 per cent alcohol for 20 seconds...
July 18, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28690485/a-novel-pathogenic-variant-in-the-mitf-gene-segregating-with-a-unique-spectrum-of-ocular-findings-in-an-extended-iranian-waardenburg-syndrome-kindred
#19
Nazanin Jalilian, Mohammad A Tabatabaiefar, Tayyeb Bahrami, Golaleh Karbasi, Mohammad H Bahramian, Abdolrahman Salimpoor, Mohammad R Noori-Daloii
Waardenburg syndrome (WS) is a rare genetic disorder characterized by abnormal pigmentation of the hair, skin, and iris as well as sensorineural hearing loss. WS is subdivided into 4 major types (WS1-4), where WS2 is characterized by the absence of dystopia canthorum. This study was launched to investigate clinical and molecular characteristics of WS in an extended Iranian WS2 family. A comprehensive clinical investigation was performed. Peripheral blood samples were collected and genomic DNA was extracted...
June 2017: Molecular Syndromology
https://www.readbyqxmd.com/read/28689749/iontophoresis-assisted-accelerated-riboflavin-ultraviolet-a-scleral-cross-linking-a-potential-treatment-for-pathologic-myopia
#20
Shuo Rong, Chaoying Wang, Baoyan Han, Pengfei Feng, Weiwei Lan, Zhipeng Gao, Xiaona Li, Weiyi Chen
Scleral collagen cross-linking is one of the most promising treatments to control the pathologic process of myopia. However, the exact procedure and its impact on animal models of myopia are still to be explored. We modified the scleral riboflavin/ultraviolet A (UVA) cross-linking procedure with an iontophoresis-assisted drug delivery system and an accelerated UVA irradiation (10 mW/cm(2), 9 min) and applied this treatment to an animal model of myopia. Ninety-six New Zealand White rabbits developed relatively stable myopia by visual deprivation and then underwent the modified scleral cross-linking surgery...
September 2017: Experimental Eye Research
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