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Myopia control

Dong Hyun Lee, Jong Wook Han, Sung Soo Kim, Suk Ho Byeon, Hyoung Jun Koh, Sung Chul Lee, Min Kim
PURPOSE: To determine the long-term effect of scleral encircling on the progression of myopia DESIGN: Retrospective, clinical cohort study METHODS: SETTING: Single-center academic hospital (Severance Hospital). STUDY POPULATION: The study included seventy-six eyes of 38 patients (mean age 37.21 ± 15.76) who have undergone retinal detachment surgery with scleral encircling OBSERVATIONAL PROCEDURES: Axial length was measured preoperatively, at 6 months after surgery, and at the most recent visit...
March 8, 2018: American Journal of Ophthalmology
Miri Na, Aeri Yoo
PURPOSE: To evaluate the effectiveness of the orthokeratology (OK) lens slowing myopic progression compared with no intervention in pediatric eyes METHODS: A retrospective review of medical records was performed on 45 monocular myopic subjects 7 to 13 years of age who were treated with monocular ortho-k lens and followed-up for more than 12 months. The monocular myopia in the subjects' eyes was -0.75 to -4.25 D (diopter), and near emmetropia in the contralateral and with-the-rule astigmatism no greater than -1...
March 9, 2018: Japanese Journal of Ophthalmology
Yu Sun, Ning Zhao, Wangyuan Liu, Miao Liu, Zizhao Ju, Jun Li, Zhen Cheng, Xingdang Liu
PURPOSE: To investigate the relationship between expression level of vesicular monoamine transporter 2 (VMAT2) and myopia, as well as the feasibility of noninvasive myopia diagnosis through imaging VMAT2 in retina by using [18 F]fluoropropyl-(+)-dihydrotetrabenazine ([18 F]FP-(+)-DTBZ). PROCEDURES: The right eyes of ten guinea pigs were deprived of vision to establish form-deprived (FD) myopia and the left eyes were untreated as the self-control eyes. The location and expression level of VMAT2 in the eyes were detected by micro-positron emission tomography (PET)/X-ray computed tomography (CT) imaging through using [18 F]FP-(+)-DTBZ...
March 8, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Kuddusi Teberik, Murat Kaya
Objective: To evaluate macular choroidal thickness (CT) and retinal thickness in Turkish patients with high myopia without maculopathy and in normal subjects and to examine the association with age, axial length (AL), best corrected visual acuity (BCVA), cycloplegic refraction, and spherical equivalent (SE). Methods: This prospective study was performed between January 2015 and June 2016 in the Department of Ophthalmology, Duzce University Medical Faculty. It had 65 individuals (30 patients with high myopia, 35 healthy subjects)...
November 2017: Pakistan Journal of Medical Sciences Quarterly
Pauline Kang
Recent increases in global myopia prevalence rates have raised significant concerns as myopia increases the lifelong risk of various sight-threatening ocular conditions. This growing public health burden has generated significant research interests into understanding both its aetiology and developing effective methods to slow down or stop its development, methods collectively termed 'myopia control'. The growing body of research has demonstrated benefits of various optical and pharmacological treatments resulting in myopia control management increasingly becoming a part of main stream clinical practice...
February 28, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Evelyn Li Min Tai, Jiunn Loong Ling, Eng Hui Gan, Hussein Adil, Wan-Hitam Wan-Hazabbah
AIM: To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured via optical coherence tomography (OCT) between different groups of myopia severity and controls. METHODS: This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction, visual field analysis and A-scan biometry. Myopic patients were classified as low myopia (LM) [spherical equivalent (SE) from greater than -0.5 D, up to -3.0 D], moderate myopia (MM; SE greater than -3...
2018: International Journal of Ophthalmology
Xinglan Li, Huazhi Zhang, Tingzhuo Zhang, Bo Yuan, Liang Tian, Fengfan Zhang, Yixin Wang, Xiang Qiao, Xiaozheng Du
OBJECTIVE: To compare the differences in the clinical therapeutic effects on juvenile myopia between Zheng 's stunt needling technique and traditional even needling technique. METHODS: A total of 166 cases of mild juvenile myopia (diopter <-3.00D) were randomized into an observation group ( Zheng 's stunt needling technique) and a control group (traditional even needling technique), 83 cases in each one (166 affected eyes). Taiyang (EX-HN 5), Fengchi (GB 20), Cuanzhu (BL 2), Hegu (LI 4) and Guangming (GB 37) were used in the two groups...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Puya Gharahkhani, Kathryn P Burdon, Jessica N Cooke Bailey, Alex W Hewitt, Matthew H Law, Louis R Pasquale, Jae H Kang, Jonathan L Haines, Emmanuelle Souzeau, Tiger Zhou, Owen M Siggs, John Landers, Mona Awadalla, Shiwani Sharma, Richard A Mills, Bronwyn Ridge, David Lynn, Robert Casson, Stuart L Graham, Ivan Goldberg, Andrew White, Paul R Healey, John Grigg, Mitchell Lawlor, Paul Mitchell, Jonathan Ruddle, Michael Coote, Mark Walland, Stephen Best, Andrea Vincent, Jesse Gale, Graham RadfordSmith, David C Whiteman, Grant W Montgomery, Nicholas G Martin, David A Mackey, Janey L Wiggs, Stuart MacGregor, Jamie E Craig
Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk loci for OAG, we performed a genome-wide association study in 3,071 OAG cases and 6,750 unscreened controls, and meta-analysed the results with GWAS data for intraocular pressure (IOP) and optic disc parameters (the overall meta-analysis sample size varying between 32,000 to 48,000 participants), which are glaucoma-related traits. We identified and independently validated four novel genome-wide significant associations within or near MYOF and CYP26A1, LINC02052 and CRYGS, LMX1B, and LMO7 using single variant tests, one additional locus (C9) using gene-based tests, and two genetic pathways - "response to fluid shear stress" and "abnormal retina morphology" - in pathway-based tests...
February 15, 2018: Scientific Reports
Alicia Ruiz-Pomeda, Belén Pérez-Sánchez, Francisco L Prieto-Garrido, Ramón Gutiérrez-Ortega, César Villa-Collar
OBJECTIVES: To assess the relative clinical success of MiSight contact lenses (CLs) (study group) and distance single-vision (SV) spectacles (control group) in children in terms of adverse events (AEs), discontinuations, and tear film osmolarity over a 2-year period. METHODS: Seventy-four subjects aged 8 to 12 with myopia of -0.75 to -4.00 D and astigmatism less than 1.00 D were randomly assigned to MiSight CLs or SV groups. Subjects were monitored at 6-month intervals over the course of 24 months and advised to report to the clinic immediately should AEs occur...
February 12, 2018: Eye & Contact Lens
Yi Wu, Carly Siu-Yin Lam, Dennis Yan-Yin Tse, Chi Ho To, Quan Liu, Sally A McFadden, Rachel Ka-Man Chun, King Kit Li, Jianfang Bian, Chuen Lam
The current study aimed to investigate the differential protein expression in guinea pig retinas in response to lens-induced myopia (LIM) before fully compensated eye growth. Four days old guinea pigs (n=5) were subjected to ‑4D LIM for 8 days. Refractive errors were measured before and at the end of the lens wear period. Ocular dimensions were also recorded using high‑frequency A‑scan ultrasonography. After the LIM treatment, retinas of both eyes were harvested and soluble proteins were extracted. Paired retinal protein expressions in each animal were profiled and compared using a sensitive fluorescence difference two‑dimensional gel electrophoresis...
February 8, 2018: Molecular Medicine Reports
Qianwen Gong, Miroslaw Janowski, Longqian Liu
No abstract text is available yet for this article.
February 8, 2018: JAMA Ophthalmology
Mark A Bullimore, David A Berntsen
No abstract text is available yet for this article.
February 8, 2018: JAMA Ophthalmology
M Diaz-Llopis, M D Pinazo-Durán
OBJECTIVE: To confirm the clinical security and effectiveness of the daily application of 0.01% superdiluted atropine eyedrops in the progression of myopia in children. MATERIAL AND METHODS: A total of 200 children 9-12 years of age were randomised into a treated group and a control without treatment. Refraction under cycloplegia was performed. RESULTS: Myopia progression of the treated group was -0.14±0.35 versus -0.65±0.54 in the control group without treatment...
February 1, 2018: Archivos de la Sociedad Española de Oftalmología
Alicia Ruiz-Pomeda, Belén Pérez-Sánchez, Isabel Valls, Francisco Luis Prieto-Garrido, Ramón Gutiérrez-Ortega, César Villa-Collar
PURPOSE: To compare myopia progression in children randomized to MiSight contact lenses (CLs) versus children corrected with single-vision spectacles (SV) over a 2-year period. METHODS: Subjects aged 8 to 12 with myopia (-0.75 to -4.00 D sphere) and astigmatism (< -1.00 D cylinder) were assigned to the lens study group (MiSight) or the control group (single vision). Measurements of visual acuity and subjective refraction were taken at 6-month intervals, and axial length, anterior chamber, corneal power, and cycloplegic autorefraction were measured at the baseline, 12-month, and 24-month visits...
February 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Gareth Lingham, Elizabeth Milne, Donna Cross, Dallas R English, Robyn S Johnston, Robyn M Lucas, Seyhan Yazar, David A Mackey
INTRODUCTION: Excessive and insufficient sun exposure during childhood have been linked to serious diseases in later life; for example, insufficient sun exposure during childhood may increase the risk of developing myopia. The Kidskin-Young Adult Myopia Study (K-YAMS) is a follow-up of participants in the Kidskin Study, a non-randomised controlled trial that evaluated the effect of a 4-year educational intervention on sun-protection behaviours among primary school children in the late 1990s...
January 31, 2018: BMJ Open
Wen-Tao Deng, Jie Li, Ping Zhu, Vince A Chiodo, W Clay Smith, Beau Freedman, Wolfgang Baehr, Jijing Pang, William W Hauswirth
Purpose: Blue cone monochromacy (BCM) is an X-linked congenital vision disorder characterized by complete loss or severely reduced L- and M-cone function. Patients with BCM display poor visual acuity, severely impaired color discrimination, myopia, nystagmus, and minimally detectable cone-mediated electroretinogram. Recent studies of patients with BCM with adaptive optics scanning laser ophthalmoscopy (AOSLO) showed that they have a disrupted cone mosaic with reduced numbers of cones in the fovea that is normally dominated by L- and M-cones...
2018: Molecular Vision
Pei-Chang Wu, Chueh-Tan Chen, Ken-Kuo Lin, Chi-Chin Sun, Chien-Neng Kuo, Hsiu-Mei Huang, Yi-Chieh Poon, Meng-Ling Yang, Chau-Yin Chen, Jou-Chen Huang, Pei-Chen Wu, I-Hui Yang, Hun-Ju Yu, Po-Chiung Fang, Chia-Ling Tsai, Shu-Ti Chiou, Yi-Hsin Yang
PURPOSE: To investigate the effectiveness of a school-based program promoting outdoor activities in Taiwan for myopia prevention and to identify protective light intensities. DESIGN: Multi-area, cluster-randomized intervention controlled trial. PARTICIPANTS: A total 693 grade 1 schoolchildren in 16 schools participated. Two hundred sixty-seven schoolchildren were in the intervention group and 426 were in the control group. METHODS: Initially, 24 schools were randomized into the intervention and control groups, but 5 and 3 schools in the intervention and control groups, respectively, withdrew before enrollment...
January 19, 2018: Ophthalmology
Li-Fang Hung, Baskar Arumugam, Lisa Ostrin, Nimesh Patel, Klaus Trier, Monica Jong, Earl L Smith Iii
Purpose: Previous studies suggest that the adenosine receptor antagonist, 7-methylxanthine (7-MX), retards myopia progression. Our aim was to determine whether 7-MX alters the compensating refractive changes produced by defocus in rhesus monkeys. Methods: Starting at age 3 weeks, monkeys were reared with -3 diopter (D; n = 10; 7-MX -3D/pl) or +3D (n = 6; 7-MX +3D/pl) spectacles over their treated eyes and zero-powered lenses over their fellow eyes. In addition, they were given 100 mg/kg of 7-MX orally twice daily throughout the lens-rearing period (age 147 ± 4 days)...
January 1, 2018: Investigative Ophthalmology & Visual Science
Takashi Kido, Weronika Sikora-Wohlfeld, Minae Kawashima, Shinichi Kikuchi, Naoyuki Kamatani, Anil Patwardhan, Richard Chen, Marina Sirota, Keiichi Kodama, Dexter Hadley, Atul J Butte
BACKGROUND: Genome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environmental factors. Natural selection has led to a high tendency of risk alleles to be enriched in minor alleles in Mendelian diseases. Therefore, an allele that was previously advantageous or neutral may later become harmful, making it a risk allele. METHODS: Using data in the NHGRI-EBI Catalog and the VARIMED database, we investigated whether (1) GWASs more easily detect risk alleles and (2) facilitate evolutionary insights by comparing risk allele frequencies of different diseases...
January 19, 2018: BMC Medical Genomics
Marc W Robboy, Gene Hilmantel, Michelle E Tarver, Malvina B Eydelman
The increased prevalence of myopia in the United States and other regions of the world, and the sight-threatening problems associated with higher levels of myopia have led to great interest in research designed to reduce these rates. As most of the progression of myopia occurs in childhood, these investigations have been directed toward slowing the progression of myopia in children. Treatments described to potentially slow the progression of myopia have included pharmacological interventions, multifocal spectacles, and multifocal correction created by contact lenses...
January 15, 2018: Eye & Contact Lens
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