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https://www.readbyqxmd.com/read/28549092/the-effect-of-spectacle-lenses-containing-peripheral-defocus-on-refractive-error-and-horizontal-eye-shape-in-the-guinea-pig
#1
Hannah E Bowrey, Guang Zeng, Dennis Y Tse, Amelia J Leotta, Yi Wu, Chi-Ho To, Christine F Wildsoet, Sally A McFadden
Purpose: It has been proposed that the peripheral retina, responding to local optical defocus, contributes to myopia and associated altered eye growth in humans. To test this hypothesis, we measured the changes in central (on-axis) and peripheral ocular dimensions in guinea pigs wearing a concentric bifocal spectacle lens design with power restricted to the periphery. Methods: Five groups of guinea pigs (n = 83) wore either a unifocal (UF) spectacle lens (-4, 0, or +4 Diopters [D]), or a peripheral defocus (PF) spectacle lens that had a plano center (diameter of 5 mm) with either -4 or +4 D in the surround (-4/0 or +4/0 D)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28538978/the-characteristics-of-deep-optic-nerve-head-morphology-in-myopic-normal-tension-glaucoma
#2
Jong Chul Han, Eun Jung Lee, Si Bum Kim, Changwon Kee
Purpose: To investigate the relationship between axial length (AL) and deep optic nerve head (ONH) structure and to evaluate the characteristics of deep ONH structures in myopic normal tension glaucoma (NTG). Methods: The following parameters were assessed using spectral-domain optical coherence tomography (SD-OCT): externally oblique border tissue (EOBT) length, ONH tilt angle, optic canal (OC) obliqueness, and β-zone peripapillary atrophy (PPA). In addition, the angular location of the maximal value of each parameter and retinal nerve fiber layer (RNFL) defect were measured using infrared and red-free photos...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28538264/lamellar-hole-associated-epiretinal-proliferation-in-lamellar-macular-hole-and-full-thickness-macular-hole-in-high-myopia
#3
Tso-Ting Lai, Chung-May Yang
PURPOSE: To report findings and surgical outcomes of lamellar macular hole (LMH) or full-thickness macular hole (FTMH) accompanied by lamellar hole-associated epiretinal proliferation (LHEP) in eyes with high myopia (HM). METHODS: Consecutive cases of HM with LMH or FTMH containing LHEP were retrospectively reviewed (study group, 43 cases). Cases of HM without LHEP (22) and those of non-HM with LHEP (30) served as Control A and B. RESULTS: The study group showed larger (928...
May 18, 2017: Retina
https://www.readbyqxmd.com/read/28534320/infectious-keratitis-and-orthokeratology-lens-use-a-systematic-review
#4
REVIEW
Ka Wai Kam, Wing Yung, Gabriel Ka Hin Li, Li Jia Chen, Alvin L Young
PURPOSE: Myopia is a prevalent condition among Asians. Orthokeratology lens has gained popularity as a method of myopia control. This systematic review is to summarize the clinical profile of infectious keratitis in association with orthokeratology lens wear. METHODS: We searched in the PubMed and EMBASE for articles adopting the search strategy "(orthokeratology lens OR orthokeratology) AND (bacterial eye infection OR keratitis OR cornea ulcer OR microbial keratitis OR bacterial keratitis)", from the start date of the databases to August 23, 2016...
May 22, 2017: Infection
https://www.readbyqxmd.com/read/28532930/comparison-of-immediate-small-incision-lenticule-extraction-after-suction-loss-with-uneventful-small-incision-lenticule-extraction
#5
Jin Hyoung Park, Hyung Jin Koo
PURPOSE: To evaluate and compare the predictability and safety of immediate small-incision lenticule extraction, also known as SMILE, after suction loss during the procedure with those of uneventful small-incision lenticule extraction. SETTING: Nunemiso Eye Center, Seoul, South Korea. DESIGN: Retrospective case series. METHODS: Patients who had immediate small-incision lenticule extraction using reapplied suction (study group) or uneventful small-incision lenticule extraction (control group) for myopia or myopic astigmatism were included...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28503426/expression-and-role-of-specificity-protein-1-in-the-sclera-remodeling-of-experimental-myopia-in-guinea-pigs
#6
Bo Jiang, Zhang-You Wu, Zi-Cheng Zhu, Gen-Jie Ke, Yue-Chun Wen, Si-Qin Sun
AIM: To study the expression of collagen I and transcription factor specificity protein 1 (Sp1), a transforming growth factor-β1 (TGF-β1) downstream target, and reveal the impact of the TGF-β1-Sp1 signaling pathway on collagen remodeling in myopic sclera. METHODS: Seventy-five 1-week-old guinea pigs were randomly divided into normal control, form deprivation myopia (FDM), and self-control groups. FDM was induced for different times using coverage with translucent latex balloons and FDM recovery was performed for 1wk after 4wk treatment; then, changes in refractive power and axial length were measured...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28494063/efficacy-and-adverse-effects-of-atropine-in-childhood-myopia-a-meta-analysis
#7
Qianwen Gong, Miroslaw Janowski, Mi Luo, Hong Wei, Bingjie Chen, Guoyuan Yang, Longqian Liu
Importance: Some uncertainty about the clinical value and dosing of atropine for the treatment of myopia in children remains. Objective: To evaluate the efficacy vs the adverse effects of various doses of atropine in the therapy for myopia in children. Data Sources: Data were obtained from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials, from inception to April 30, 2016. The reference lists of published reviews and clinicaltrials...
May 11, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28486721/topography-guided-lasik-versus-small-incision-lenticule-extraction-smile-for-myopia-and-myopic-astigmatism-a-randomized-prospective-contralateral-eye-study
#8
Anastasios John Kanellopoulos
PURPOSE: To compare safety and efficacy of topography-guided LASIK and contralateral eye SMILE for myopia and myopic astigmatism correction. METHODS: This prospective, randomized contralateral eye study included 44 eyes of 22 patients with bilateral myopia or myopic astigmatism. Treated eyes were divided into two groups: 22 eyes were treated with topography-guided LASIK and the fellow eye of each patient was treated with SMILE. The following parameters were evaluated preoperatively and up to 3 months postoperatively: uncorrected distance vision acuity (UDVA), corrected distance vision acuity (CDVA), refractive error, corneal keratometry, contrast sensitivity, and Objective Scatter Index...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28486720/comparative-analysis-of-the-clinical-outcomes-of-smile-and-wavefront-guided-lasik-in-low-and-moderate-myopia
#9
Mounir A Khalifa, Ahmed Ghoneim, Mohamed Shafik Shaheen, Mohamed G Aly, David P Piñero
PURPOSE: To compare the clinical outcomes of small incision lenticule extraction (SMILE) and wavefront-guided LASIK (WFG LASIK) in eyes with low and moderate myopia. METHODS: This was a prospective, comparative study enrolling 110 eyes with low and moderate myopia (spherical equivalent ≤ 6.00 diopters [D]). Two groups were differentiated according to the surgical technique used: the WFG LASIK group included 51 eyes (51 patients) undergoing WFG LASIK using the STAR S4IR excimer laser and the iDesign aberrometer (Abbott Medical Optics, Abbott Park, IL) and the SMILE group included 59 eyes (59 patients) undergoing SMILE with the VisuMax platform (Carl Zeiss Meditec, Jena, Germany)...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28484309/identification-of-seven-novel-znf469-mutations-in-keratoconus-patients-in-a-han-chinese-population
#10
Xiaoning Yu, Binbin Chen, Xin Zhang, Xingchao Shentu
PURPOSE: To test for the potential presence of novel mutations in the zinc finger protein (ZNF469) gene in patients with sporadic keratoconus (KC) from a Han Chinese population. METHODS: Fifty-three patients with primary KC, 30 patients with high myopia (HM), and 100 unrelated population-matched healthy controls without any ocular or systemic disorders, all of Han Chinese ethnicity, were recruited. Blood samples were donated, and genomic DNA was isolated from peripheral blood leukocytes...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28482825/effect-of-limbal-relaxing-incisions-during-implantable-collamer-lens-surgery
#11
Zhen Li, Yu Han, Budan Hu, Huibin Du, Gengsheng Hao, Xiaoxi Chen
BACKGROUND: The limbal relaxing incisions (LRIs) technique is a safe and an inexpensive procedure, which is simple for experts to perform. It can effectively reduce astigmatism and result in a rapid visual rehabilitation. But there are few reports about reducing pre-existing corneal astigmatism by LRI in ICL surgery. Our research was aimed to study the effect of limbal relaxing inci sions during implantable collamer lens (ICL) surgery. METHODS: A prospective analysis reviewing consecutive cases of corneal astigmatism that had either independent ICL surgery (control group) or combined with LRIs (LRIs group)...
May 8, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28477073/-riboflavin-uva-crosslinking-in-progressive-keratoconus
#12
P Maier, T Reinhard
In patients with keratoconus, a progressive, ectatic disease of the cornea, the shape of the cornea is continuously changing leading to a reduction in visual acuity by progressive myopia and more and more (irregular) astigmatism. The symptomatic treatment consists of the prescription of glasses or special gas-permeable rigid contact lenses. Corneal tomography is generally used for diagnosis. After initial diagnosis of keratoconus, regular tomographic follow-ups should be performed. If clinically significant progression is found and confirmed by repeated measurements, riboflavin UVA collagen crosslinking should be offered to the patients...
May 5, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28442722/mutational-screening-of-slc39a5-leprel1-and-lrpap1-in-a-cohort-of-187-high-myopia-patients
#13
Chun-Yun Feng, Xiao-Qiong Huang, Xue-Wen Cheng, Rong-Han Wu, Fan Lu, Zi-Bing Jin
High myopia (HM) is a leading cause of mid-way blindness with a high heritability in East Asia. Although only a few disease genes have been reported, a small proportion of patients could be identified with genetic predispositions. In order to expand the mutation spectrum of the causative genes in Chinese adult population, we investigated three genes, SLC39A5, LEPREL1 and LRPAP1, in a cohort of 187 independent Chinese patients with high myopia. Sanger sequencing was used to find possible pathogenic mutations, which were further screened in normal controls...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442706/nitric-oxide-no-mediates-the-inhibition-of-form-deprivation-myopia-by-atropine-in-chicks
#14
Brittany J Carr, William K Stell
Myopia is the most common childhood refractive disorder. Atropine inhibits myopia progression, but its mechanism is unknown. Here, we show that myopia-prevention by atropine requires production of nitric oxide (NO). Form-deprivation myopia (FDM) was induced in week-old chicks by diffusers over the right eye (OD); the left eye (OS) remained ungoggled. On post-goggling days 1, 3, and 5, OD received intravitreally 20 µL of phosphate-buffered saline (vehicle), or vehicle plus: NO source: L-arginine (L-Arg, 60-6,000 nmol) or sodium nitroprusside (SNP, 10-1,000 nmol); atropine (240 nmol); NO inhibitors: L-NIO or L-NMMA (6 nmol); negative controls: D-Arg (10 µmol) or D-NMMA (6 nmol); or atropine plus L-NIO, L-NMMA, or D-NMMA; OS received vehicle...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28430330/long-term-visual-outcomes-in-children-with-primary-congenital-glaucoma
#15
Sanaa A Yassin
PURPOSE: To determine the long-term visual outcomes and risk factors for visual loss in children with primary congenital glaucoma (PCG) who underwent angle surgery over a 21-year period. METHODS: This was a retrospective study of patients who underwent trabeculotomy, trabeculectomy, or combined trabeculotomy-trabeculectomy for PCG. Visual acuity (VA), surgeries, and underlying cause of visual impairment were recorded and compared. Main outcome measures were final best-corrected good VA (20/20 to 20/50), moderate VA (<20/50 to 20/200), or poor VA (<20/200); age at surgery, sex, laterality, type of initial glaucoma surgery, and number of surgeries were recorded...
April 20, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28419360/p4ha1-mutations-cause-a-unique-congenital-disorder-of-connective-tissue-involving-tendon-bone-muscle-and-the-eye
#16
Yaqun Zou, Sandra Donkervoort, Antti M Salo, A Reghan Foley, Aileen M Barnes, Ying Hu, Elena Makareeva, Meganne E Leach, Payam Mohassel, Jahannaz Dastgir, Matthew A Deardorff, Ronald D Cohn, Wendy O DiNonno, Fransiska Malfait, Monkol Lek, Sergey Leikin, Joan C Marini, Johanna Myllyharju, Carsten G Bönnemann
Collagen prolyl 4-hydroxylases (C-P4Hs) play a central role in the formation and stabilization of the triple helical domain of collagens. P4HA1 encodes the catalytic α(I) subunit of the main C-P4H isoenzyme (C-P4H-I). We now report human bi-allelic P4HA1 mutations in a family with a congenital-onset disorder of connective tissue, manifesting as early-onset joint hypermobility, joint contractures, muscle weakness and bone dysplasia as well as high myopia, with evidence of clinical improvement of motor function over time in the surviving patient...
April 13, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28414805/measurements-of-the-parapapillary-atrophy-zones-in-en-face-optical-coherence-tomography-images
#17
Atsuya Miki, Yasushi Ikuno, Robert N Weinreb, Junko Yokoyama, Tomoko Asai, Shinichi Usui, Kohji Nishida
OBJECTIVE: To measure the parapapillary atrophy (PPA) area in en face images obtained with swept-source optical coherence tomography (SS-OCT), and to evaluate its relationship to glaucoma, myopia, and age in non-highly myopic subjects. DESIGN: Retrospective, cross-sectional study. PARTICIPANTS: Fifty eyes of 30 subjects with open-angle glaucoma (G group) and forty-three eyes of 26 healthy control subjects (C group). Eyes with high myopia (spherical equivalent refractive error ≤ -8 diopters or axial length ≥ 26...
2017: PloS One
https://www.readbyqxmd.com/read/28410280/long-term-impacts-of-orthokeratology-treatment-on-sub-basal-nerve-plexus-and-corneal-sensitivity-responses-and-their-reversibility
#18
María Nombela-Palomo, Gema Felipe-Marquez, Miguel Angel Teus, Jose Luis Hernandez-Verdejo, Amelia Nieto-Bona
PURPOSE: To examine the effects of one year of overnight orthokeratology (OK) treatment on the sub-basal nerve plexus (SBNP) and corneal sensitivity and to assess the reversibility of these effects one month after treatment interruption. METHODS: Thirty-two subjects with low-moderate myopia underwent OK treatment for one year. Fifteen non-contact lens wearers served as controls. At the time points baseline, one year of treatment, and one month after removing the OK lenses, two tests were conducted: corneal sensitivity (Cochet-Bonnet esthesiometer) and SBNP imaging by in vivo confocal microscopy...
April 13, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28388896/comparison-of-ocular-higher-order-aberrations-after-smile-and-wavefront-guided-femtosecond-lasik-for-myopia
#19
Xiaoqin Chen, Yan Wang, Jiamei Zhang, Shun-Nan Yang, Xiaojing Li, Lin Zhang
BACKGROUND: To compare changes in higher-order aberrations (HOAs) following small incision lenticule extraction (SMILE) and wavefront-guided femtosecond laser-assisted in situ keratomileusis (WFG FS-LASIK), and to investigate correlations between preoperative spherical equivalence (SE) and components of HOAs affecting visual quality. METHODS: Sixty-five myopic eyes from 38 patients were enrolled in the study retrospectively, either having undergone SMILE or WFG FS-LASIK...
April 7, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28388703/quantitative-oct-angiography-of-the-retinal-microvasculature-and-the-choriocapillaris-in-myopic-eyes
#20
Mayss Al-Sheikh, Nopasak Phasukkijwatana, Rosa Dolz-Marco, Mansour Rahimi, Nicholas A Iafe, K Bailey Freund, SriniVas R Sadda, David Sarraf
Purpose: To study the retinal capillary microvasculature and the choriocapillaris (CC) in myopic eyes using quantitative optical coherence tomography angiography (OCTA) analysis. Methods: Macular OCTA images of 3 × 3 mm were obtained using the RTVue-XR Avanti with AngioVue. Quantitative measurements of the retinal capillary microvascular layers and the CC were analyzed using en face projection images. Vessel density and fractal dimension of the superficial and deep retinal capillary plexus, and area and density of flow reduction in the CC were analyzed, quantified, and compared with an age-matched control group...
April 1, 2017: Investigative Ophthalmology & Visual Science
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