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Robert M Starke, David McCarthy, Ricardo J Komotar, E Sander Connolly
No abstract text is available yet for this article.
July 1, 2018: Neurosurgery
Pamela T Johnson, Elliot K Fishman
No abstract text is available yet for this article.
June 19, 2018: Radiology
Katie L Mowers, Lynne Sekarski, Andrew J White, R Mark Grady
No abstract text is available yet for this article.
January 1, 2018: Pulmonary Circulation
B Sunil Abhishek, Anupam Bhambhani
Ischaemic stroke is among the leading causes of disability and death. Despite extensive vascular, cardiac and serological evaluations, the cause remains unknown in 20%-40% of patients. These are classified as cryptogenic stroke. Paradoxical embolism is one of the many causes of cryptogenic stroke. The term paradoxical embolism is used to describe an embolus of venous origin entering the systemic circulation through a patent foramen ovale (PFO), atrial septal defect (ASD), ventricular septal defect or extracardiac communication such as pulmonary arteriovenous malformation...
September 2017: National Medical Journal of India
Abdulrahman M Al-Nemri, Fahd Alsohime, Asfaq H Shaik, Ghasan A El-Hissi, Mohammed I Al-Agha, Nada F Al-Abdulkarim, Sarar Mohamed
OBJECTIVES: To determine the perinatal and neonatal morbidity related to diabetes associated with pregnancy. METHODS: This is a prospective cohort study conducted at a tertiary university hospital in Central Saudi Arabia. All neonates born to mothers with pregnancy associated diabetes between July 2014 and June 2015 were recruited for the purpose of this study. Infants born at 23 weeks or less, infants who died within 3 hours of delivery, twins, and unbooked pregnant ladies were excluded from the study...
June 2018: Saudi Medical Journal
P Naina, Mary John, Mohamed Abdul Kathar, Manish Kumar
Tracheal agenesis is a rare but fatal congenital tracheal malformation. Lack of prenatal symptom and a typical clinical presentation lead to failure to arrive at a correct diagnosis and confusion during resuscitation. We report a case of a newborn male child with type 2 tracheal agenesis. Despite a typical presentation, diagnosis was delayed after unsuccessful intubation, examination under anaesthesia and emergency tracheostomy. The embryology, diagnostic criteria and potential treatment options are discussed...
June 17, 2018: BMJ Case Reports
Hyun Joon Choi, Hyun-Tai Chung, Jason W Sohn, Chul Hee Min
Leksell GammaPlan was specifically designed for Gamma Knife (GK) radiosurgery planning, but it has limited accuracy for estimating the dose distribution in inhomogeneous areas, such as the embolization of arteriovenous malformations. We aimed to develop an independent patient dose validation system based on a patient-specific model, constructed using a DICOM-RT interface and the Geant4 toolkit. Leksell Gamma Knife Perfexion was designed in Geant4.10.00 and includes a DICOM-RT interface. Output factors for each collimator in a sector and dose distributions in a spherical water phantom calculated using a Monte Carlo (MC) algorithm were compared with the output factors calculated by the tissue maximum ratio (TMR) 10 algorithm and dose distributions measured using film, respectively...
June 15, 2018: Physica Medica: PM
Estela Pérez Ruiz, Pilar Caro Aguilera, Ana Isabel Valdivielso, Sonia Sanchís Cárdenas, Yazmina Martínez García, Javier Pérez Frías
This paper describes the clinical features of paediatric patients with tracheal bronchus (TB) identified with flexible bronchoscopy (FB) in a tertiary care hospital. A retrospective review of every FB with diagnosis of TB carried out in our centre since 1990 was performed which considered specifically: age at diagnosis, gender, semiology, somatic anomalies, tracheal bronchus type, other bronchoscopic findings and clinical progress. Out of 1665 FB in 1337 patients, TB was found in 26 (1.9%). The median age was 15 months (age range 1 month-13 years), with no gender differences...
May 19, 2018: Paediatric Respiratory Reviews
Jung-Eun Moon, Su-Jeong Lee, Cheol Woo Ko
BACKGROUND: Kabuki syndrome is characterized by distinctive facial features and varying degrees of growth retardation. It leads to malformations in skeletal, urogenital and cardiac structures; moreover, endocrine conditions such as premature thelarche, precocious puberty, growth hormone deficiency, diabetes insipidus, thyroid dysfunction and obesity have been reported. Kabuki syndrome is caused by a heterozygous mutation in the KMT2D or KDM6A genes. CASE PRESENTATION: An 11-year-old girl with the typical facial features of Kabuki syndrome visited our hospital due to her short stature...
June 18, 2018: BMC Medical Genetics
Rita Alexandra Pinto, José Almeida-Santos, Raquel Lourenço, Leonor Saúde
BACKGROUND: Dmrt2a is a zinc finger like transcription factor with several roles during zebrafish early development: left-right asymmetry, synchronisation of the somite clock genes and fast muscle differentiation. Despite the described functions, Dmrt2a mechanism of action is unknown. Therefore, with this work, we propose to identify Dmrt2a downstream genes during zebrafish early development. RESULTS: We generated and validated a heat-shock inducible transgenic line, to timely control dmrt2a overexpression, and dmrt2a mutant lines...
June 19, 2018: BMC Developmental Biology
Emine Aydin, Ebru Aypar, Ahmet Oktem, Ozgur Ozyuncu, Murat Yurdakok, Murat Guvener, Metin Demircin, M Sinan Beksac
OBJECTIVE: We aimed to evaluate congenital heart disease (CHD) cases according to EUROCAT subgroup classification that were diagnosed during the prenatal period in our center. METHODS: CHDs that were prenatally diagnosed using ultrasonography and confirmed by fetal echocardiography were reviewed over a 10-year period. Subgroup classification was finalized at the post-partum period in terms of the EUROCAT guide 1.3. Congenital heart defect subtypes and obstetric outcomes (gestational week at delivery, birth weight, gender, extracardiac structural abnormalities, karyotype results if performed) were analyzed...
June 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
Dandan Xu, Ge Yu, Pinggen Xi, Xiangyu Kong, Qi Wang, Lingwang Gao, Zide Jiang
Botrytis cinerea is the pathogen of gray mold disease affecting a wide range of plant hosts, with consequential economic losses worldwide. The increased frequency of fungicide resistance of the pathogen challenges its disease management, and thus the development of alternative control strategies are urgently required. In this study, we showed excellent synergistic interactions between resveratrol and pyrimethanil. Significant synergistic values were recorded by the two-drug combination on the suppression of mycelial growth and conidia germination of B...
June 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Christoph Haller, Christopher A Caldarone
Hybrid palliation, the concept to stabilize univentricular circulation with bilateral pulmonary artery banding and maintenance of ductal patency, has significantly widened the therapeutic spectrum for patients with single ventricle malformations or borderline hypoplasia. Although the concept has already been a part of early attempts to improve outcome in hypoplastic left heart syndrome, it has not attracted much attention initially. Technical refinement and expertise have led to results that ultimately allowed the palliative strategy to gain traction and to be selectively adopted...
June 15, 2018: Annals of Thoracic Surgery
Areti Angeliki Veroniki, Jesmin Antony, Sharon E Straus, Huda M Ashoor, Yaron Finkelstein, Paul A Khan, Marco Ghassemi, Erik Blondal, John D Ivory, Brian Hutton, Kevin Gough, Brenda R Hemmelgarn, Erin Lillie, Afshin Vafaei, Andrea C Tricco
BACKGROUND: Nearly all newly infected children acquire Human Immunodeficiency virus (HIV) via mother-to-child transmission (MTCT) during pregnancy, labour or breastfeeding from untreated HIV-positive mothers. Antiretroviral therapy (ART) is the standard care for pregnant women with HIV. However, evidence of ART effectiveness and harms in infants and children of HIV-positive pregnant women exposed to ART has been largely inconclusive. The aim of our systematic review and network meta-analysis (NMA) was to evaluate the comparative safety and effectiveness of ART drugs in children exposed to maternal HIV and ART (or no ART/placebo) across different study designs...
2018: PloS One
Chin-Tung Lau, Kenneth K Y Wong
Thoracoscopic resection is being used more commonly for the treatment of congenital cystic adenomatoid malformation in neonates and infants. However, in the rare case of congenital cystic adenomatoid malformation with congenital absence of lung fissure, thoracoscopic lobectomy cannot be performed safely. Moreover, if the lung lesion is deep-seated and cannot be visualized on the pleural surface, wedge resection may result in residual lesion. Here, we reported our approach of thoracoscopic resection under hookwire guidance to tackle this problem...
June 14, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Julia K Shinnick, Shabnam Jain, Adina L Alazraki, Megan M Durham
Gastrointestinal duplication cysts are rare congenital malformations, with esophageal and gastric duplication cysts being among the rarest. We report an 8-week-old female who presented to the emergency department with failure to thrive and was subsequently found to have multiple gastric and esophageal duplication cysts that had ruptured intrathoracically and intra-abdominally. We describe the diagnosis and management of this patient who underwent successful resection of 4 gastrointestinal duplication cysts...
June 14, 2018: Pediatric Emergency Care
Rodolfo Citro, Moreno Cecconi, Salvatore La Carrubba, Eduardo Bossone, Francesco Antonini-Canterin, Stefano Nistri, Fabio Chirillo, Ilaria Dentamaro, Michele Bellino, Alfredo Posteraro, Mauro Giorgi, Licia Petrella, Ines Monte, Vincenzo Manuppelli, Antonio Mantero, Scipione Carerj, Frank Benedetto, Paolo Colonna
Background: Bicuspid aortic valve (BAV) is the most common congenital heart disease, affecting 0.5%-2% of the general population. It is associated not only with notable valvular risk (aortic stenosis and/or regurgitation, endocarditis) but also with aortopathy with a wide spectrum of unpredictable clinical presentations, including aneurysmal dilation of the aortic root and/or ascending thoracic aorta, isthmic coarctation, aortic dissection, or wall rupture. Methods: The REgistro della Valvola Aortica Bicuspide della Società Italiana di ECocardiografia e CArdiovascular Imaging is a retrospective (from January 1, 2010)/prospective, multicenter, observational registry, expected to enroll 3000 patients with definitive diagnosis of BAV made by transthoracic and/or transesophageal echocardiography, computed tomography, cardiovascular magnetic resonance, or at surgery...
April 2018: Journal of Cardiovascular Echography
Alec Sherman, Stanley Kim, William Craft, Daniel Lewis
A 5-year-old neutered male Labrador retriever dog with a 3-year history of intermittent hemorrhage from the right metacarpal pad was evaluated. A small region of hyperattenuation of the metacarpal pad was evident on computed tomographic angiography. Excisional biopsy of the location of the purported hemorrhage revealed a micro-arteriovenous malformation on histologic examination.
June 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
S B Hiremath, A A Gautam, V Sasindran, J Therakathu, G Benjamin
Cerebrospinal fluid (CSF) leaks are extracranial egress of CSF into the adjacent paranasal sinus or tympanomastoid cavity due to an osteodural defect involving skull base. It can be due to a multitude of causes including accidental or iatrogenic trauma, congenital malformations and spontaneous leaks. Accurate localization of the site of the leak, underlying causes and appropriate therapy is necessary to avoid associated complications. In this paper relevant anatomy, clinical diagnosis, imaging modalities and associated findings are discussed along with a brief mention about management...
June 14, 2018: Diagnostic and Interventional Imaging
N F Benatta, D D Batouche, M A Djazouli
INTRODUCTION: The heart prosthesis pregnant women are becoming more frequent due to the persistence of rheumatic fever in the country sends developments. OBJECTIVE: To propose management strategies from preconception to pregnancy and postpartum. MATERIALS AND METHODS: Prospective study from 2009-2014 about parturientes followed in cardiology and maternity on center Hospitalo University Oran. RESULTS: Thirty patients were followed, ejection fraction was equal to 60% in 29 cases...
June 14, 2018: Annales de Cardiologie et D'angéiologie
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