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https://www.readbyqxmd.com/read/29029311/use-of-colchicine-in-pregnancy-a-systematic-review-and-meta-analysis
#1
Praveen L Indraratna, Sohaib Virk, Divya Gurram, Richard O Day
Objectives: Colchicine is an anti-inflammatory agent used in the treatment of several rheumatological conditions. The use of colchicine in pregnancy is controversial. The current study aimed to systematically review and meta-analyse the existing data in the literature regarding the safety of colchicine in pregnancy. Methods: A systematic review was carried out using six electronic databases, identifying all relevant studies where colchicine was administered to pregnant women, and where pregnancy-related outcomes were measured...
September 23, 2017: Rheumatology
https://www.readbyqxmd.com/read/29028550/paternal-exposure-to-environmental-17-alpha-ethinylestradiol-concentrations-modifies-testicular-transcription-affecting-the-sperm-transcript-content-and-the-offspring-performance-in-zebrafish
#2
David G Valcarce, Elena Vuelta, Vanesa Robles, Maria Paz Herráez
The synthetic estrogen 17-α-ethinylestradiol (EE2), a major constituent in contraceptive pills, is an endocrine disrupting chemical (EDC) present in the aquatic environment at concentrations of ng/L. Developmental exposure to these low concentrations in fish can induce several disorders. Zebrafish (Danio rerio) is a perfect organism for monitoring the effects of environmental contaminants. Our hypothesis is that changes promoted by EE2 in the germ line of male adults could be transmitted to the unexposed progeny...
September 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29028157/transthoracic-catheter-drainage-for-large-symptomatic-congenital-pulmonary-airway-malformation
#3
Seong Hee Oh, Chae Young Kim, Byong Sop Lee, Dong Kwan Kim, Ellen Ai-Rhan Kim, Ki-Soo Kim
BACKGROUND: Surgical resection of large symptomatic congenital pulmonary airway malformation (CPAM) in newborns has high risks of mortality and postoperative morbidity. This study aimed to report the clinical outcomes of newborns who underwent percutaneous transthoracic catheter drainage (PTCD) of large symptomatic CPAM before surgical resection. METHODS: This was a retrospective, descriptive study based on review of the medical records of newborn infants who required surgical resection of large symptomatic CPAM at a single tertiary hospital from 2001 to 2017...
October 13, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29027876/intradural-pathology-and-pathophysiology-associated-with-chiari-i-malformation-in-children-and-adults-with-and-without-syringomyelia
#4
Brian J Dlouhy, Jeffrey D Dawson, Arnold H Menezes
OBJECTIVE The pathophysiology underlying tonsillar herniation and CSF obstruction in Chiari malformation Type I (CM-I) is unclear, and the cause of CM-I-associated syringomyelia is not well understood. A better understanding of this pathophysiology is important for an improved treatment strategy. Therefore, the authors sought to identify, characterize, and examine the intradural pathology and CSF flow pathophysiology in the posterior fossa and at the level of the foramen magnum that occurs in the setting of CM-I...
October 13, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29027857/is-there-added-value-in-obtaining-cervical-spine-mri-in-the-assessment-of-nontraumatic-angiographically-negative-subarachnoid-hemorrhage-a-retrospective-study-and-meta-analysis-of-the-literature
#5
Gelareh Sadigh, Chad A Holder, Jeffrey M Switchenko, Seena Dehkharghani, Jason W Allen
OBJECTIVE Diagnostic algorithms for nontraumatic angiographically negative subarachnoid hemorrhage (AN-SAH) vary, and the optimal method remains subject to debate. This study assessed the added value of cervical spine MRI in identifying a cause for nontraumatic AN-SAH. METHODS Consecutive patients 18 years of age or older who presented with nontraumatic SAH between February 1, 2009, and October 31, 2014, with negative cerebrovascular catheter angiography and subsequent cervical MRI were studied. Patients with intraparenchymal, subdural, or epidural hemorrhage; recent trauma; or known vascular malformations were excluded...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29027670/chiari-like-malformation-in-two-cats
#6
S Minato, M Baroni
Two male, neutered, domestic, shorthaired cats were evaluated for progressive paresis and ataxia. Neurological examinations suggested a spinal cord lesion in each case. Complete blood examination and cerebrospinal fluid analysis were unremarkable in both cats. MRI revealed malformation of the occipital bone with herniation of the cerebellar vermis through the foramen magnum but without syringomyelia. Chiari-like malformation was suspected in both patients. MRI repeated one year later in both cats because of progression of clinical signs yielded the same findings as the initial scans...
October 13, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29027581/unusual-case-of-coronal-complete-bladder-duplication-associated-with-rectoprostatic-fistula-to-duplicated-prostatic-urethra
#7
Jennifer Y Lam, Steven R Lopushinsky, Kyle C Kurek, Paul Beaudry
Anorectal malformations are a common congenital anomaly, while bladder duplication is rare. Bladder duplications are classified as complete or incomplete and sagittal or coronal. We present a rare case of coronal complete bladder duplication with rectoprostatic fistula to the blind ending prostatic urethra of the duplicated bladder.
October 13, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29027529/-twin-pregnancy-with-complete-hydatidiform-mole
#8
I N Voloshchuk, I V Barinova, N I Kondrikov, R A Barto
The paper describes a case of twin pregnancy with complete hydatidiform mole (CHM). According to the data available in the literature, the concurrence of CHM with a normal placenta and a viable fetus occurs in 1 per 20,000-100,000 pregnancies, requires a differential diagnosis with partial hydatidiform mole and placental mesenchymal dysplasia, and is characterized by a high rate of complications. In this concurrence, the frequency of persistent trophoblastic disease is as high as 50%. In this case, the pregnancy ended in a spontaneous abortion at 16-17 weeks of pregnancy...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/29026809/spontaneously-resolved-macrocystic-lymphatic-malformations-predictive-variables-and-outcomes
#9
Michael J Phang, Douglas J Courtemanche, Marija Bucevska, Claudia Malic, Jugpal S Arneja
INTRODUCTION: Lymphatic malformations are benign, low-flow vascular malformations that typically present at or near birth. Due to morbidity associated with operative treatment, nonoperative treatment with injection of sclerosant has become the mainstay of therapy. Over the past 15 years, several patients at our centre with macrocystic (>2 cm cyst size) lymphatic malformations have seen their lesions resolve spontaneously while awaiting treatment. In this study, we review features of these patients that may contribute to spontaneous resolution...
February 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29026689/accurate-diagnosis-of-prenatal-cleft-lip-palate-by-understanding-the-embryology
#10
REVIEW
Bram Smarius, Charlotte Loozen, Wendy Manten, Mireille Bekker, Lou Pistorius, Corstiaan Breugem
Cleft lip with or without cleft palate (CP) is one of the most common congenital malformations. Ultrasonographers involved in the routine 20-wk ultrasound screening could encounter these malformations. The face and palate develop in a very characteristic way. For ultrasonographers involved in screening these patients it is crucial to have a thorough understanding of the embryology of the face. This could help them to make a more accurate diagnosis and save time during the ultrasound. Subsequently, the current postnatal classification will be discussed to facilitate the communication with the CP teams...
September 26, 2017: World Journal of Methodology
https://www.readbyqxmd.com/read/29026674/chronic-headache-caused-by-a-titanium-fixation-plate-report-of-two-cases
#11
Shigeomi Yokoya, Akihiko Hino, Hideki Oka
BACKGROUND: We report two patients with chronic postcraniotomy headache who showed rapid alleviation of pain after removal of titanium miniplates. CASE DESCRIPTION: (Case 1) A 26-year-old woman underwent a right frontal craniotomy and excision of the entire cerebral cavernous malformation. Eleven years later, she developed headache. The titanium plate was removed and the patient presented complete amelioration of headache. (Case 2) A 50-year-old man underwent an aneurysm clipping via the lateral supraorbital approach of the left side...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29026673/endoscopic-management-of-a-cavernous-malformation-on-the-floor-of-third-ventricle-and-aqueduct-of-sylvius-technical-case-report-and-review-of-the-literature
#12
Luis Alberto Ortega-Porcayo, Alexander Perdomo-Pantoja, Isaac Jair Palacios-Ortíz, Salomon Cohen Cohen, Juan Pablo González-Mosqueda, Juan Luis Gómez-Amador
BACKGROUND: Intraventricular cavernous malformations are unusual intracranial vascular malformations; their deep anatomical location complicates their surgical management. Microsurgical approaches are the gold standard approaches for the resection of ventricular lesions, however, they imply considerable neurovascular risks. CASE DESCRIPTION: A 51-year-old patient presented with acute headache, diplopia, vertigo, blurred vision, and a depressed level of consciousness...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29026517/dermatofibrosarcoma-protuberans-coexisting-in-a-patient-with-a-vascular-malformation-a-rare-coincidence
#13
Parthena Deskoulidi, Michael Sofopoulos, Pantelis Diamantopoulos, Thaleia Nikolaidou, Nikolaos Maltzaris, Maria Theodorakopoulou, Christos Klonaris, Niki Arnogiannaki, Maria Kotrotsiou, Spiros Stavrianos
Dermatofibrosarcoma protuberans with fibrosarcomatous differentiation (DFSP-FS) is a rare soft tissue tumor with more aggressive behavior and it is not clear what causes this type of skin cancer. We describe the case of a 48-year-old woman who was born with a vascular malformation in the sternal region and presented suddenly with a soft tissue sarcoma (DFSP-FS) in the same territory. She was initially treated by embolization as the sarcoma was misdiagnosed but the tumor within 6 months seemed to be growing rapidly and reached a giant dimension with ulceration and required surgical intervention...
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29026415/two-cases-of-parachute-tricuspid-valve-confirmed-by-three-dimensional-echocardiography
#14
Hedieh Alimi, Afsoon Fazlinezhad
BACKGROUND: Parachute tricuspid valve is a rare congenital malformations explained in the literature. In most cases, this malformation coexists with other congenital defects. The importance of this condition depends on its functional consequences. CASE REPORT: First case was a 52-year-old female patient presented with palpitation. She had a history of paroxysmal supraventricular tachycardia. Transthoracic echocardiography revealed large secundum type atrial septal defect and all the tricuspid valve leaflets appeared to be connected to a single calcified papillary muscle in right ventricle suggestive of parachute tricuspid valve...
March 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29026365/incidental-finding-of-bronchopulmonary-sequestration-in-a-64-year-old-female
#15
Pichapong Tunsupon, Ayesha Arshad, Sumit Patel, M Jeffery Mador
BACKGROUND: Bronchopulmonary sequestration is a congenital abnormality of the primitive foregut. In adults, the typical age at presentation is 20-25 years. CASE REPORT: A 64-year-old female was referred for evaluation of an 8 × 6-cm right lower lobe cystic lesion. Her medical history was significant for recurrent right lower lobe pneumonia requiring multiple hospitalizations. Her physical examination was significant for crackles at the right lung base. Computed tomography (CT) of the chest with contrast showed cystic changes with thickened septation of the medial segment of the right lower lobe lacking distinct visceral pleura and with arterial supply from the anomalous branch of the thoracic aorta arising near the celiac trunk...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29025196/prenatal-molecular-diagnosis-in-rasa1-related-disease
#16
Aurélien Palmyre, Mélanie Eyries, Marie-Victoire Senat, Augustin Ozanne, Stéphanie Staraci, Philippe Dufour, Thierry Chinet, Pascal Lacombe, Florent Soubrier, Philippe Charron
RASA1-related disease is a rare autosomal dominant disease characterized by capillary malformations, arteriovenous malformations (AVMs) and/or arteriovenous fistulas (AFVs). Penetrance is nearly complete and vascular malformations may cause serious complications such as organ injury due to oxygenation disorder, brain abscess, hemorrhage and stroke. Early diagnosis is useful in order to discuss optimal management, including AVMs/AVFs embolization or surgical procedures, and try to prevent some of the complications...
October 12, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29025148/type-2-split-cord-malformation-the-martian-sign
#17
M S F Md Noh, N Rajadurai
No abstract text is available yet for this article.
July 21, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29024832/somatic-second-hit-mutation-of-rasa1-in-vascular-endothelial-cells-in-capillary-malformation-arteriovenous-malformation
#18
Philip E Lapinski, Abbas Doosti, Valerie Salato, Paula North, Patricia E Burrows, Philip D King
Capillary malformation-arteriovenous malformation (CM-AVM) is an autosomal dominant vascular disorder that is associated with inherited inactivating mutations of the RASA1 gene in the majority of cases. Characteristically, patients exhibit one or more focal cutaneous CM that may occur alone or together with AVM, arteriovenous fistulas or lymphatic vessel abnormalities. The focal nature and varying presentation of lesions has led to the hypothesis that somatic "second hit" inactivating mutations of RASA1 are necessary for disease development...
October 9, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29024719/calcification-or-not-this-is-the-question-a-one-year-study-of-bovine-pericardial-vascular-patches-cardiocel%C3%A2-in-minipigs
#19
Aida Salameh, Wiebke Greimann, David Vondrys, Martin Kostelka
Objectives A main problem with bioprosthesis used for surgical correction of congenital cardiac malformation is their tendency to shrink and to calcify. Recently, a new material i.e. de-cellularised bovine pericardium (CardioCel(®)) was introduced in clinics. It was proposed that this new patch material should not calcify and should be particularly suitable for the correction of vascular defects in inborn cardiac diseases. The aim of our chronic minipig study was to evaluate the performance of CardioCel(®) patches implanted in aortic and pulmonary artery position, respectively...
October 9, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29024135/congenital-uterine-malformation-by-experts-cume-better-criteria-for-distinguishing-between-normal-arcuate-and-septate-uterus
#20
Artur Ludwin, Wellington P Martins, Carolina O Nastri, Inga Ludwin, Marcela A Coelho Neto, Valeria M Leitão, Maribel Acién, Juan L Alcazar, Beryl Benacerraf, George Condous, Rudy-Leon De Wilde, Mark Hans Emanuel, William Gibbons, Stefano Guerriero, William W Hurd, Deborah Levine, Steven Lindheim, Antonio Pellicer, Felice Petraglia, Ertan Saridogan
OBJECTIVES: To assess whether level of agreement among experts in distinguishing between septate and normal/arcuate uterus using subjective judgments from review of coronal view from three-dimensional ultrasound. We also aim to determine the inter-observer reliability and diagnostic test accuracy of three measurements suggested by recent guidelines, using the most voted option by experts (CUME - Congenital Uterine Malformation by Experts) as a reference standard. METHODS: Images of the coronal plane of the uterus from 100 women with suspected fundal internal indentation were anonymized and submitted to 15 experts (5 clinicians, 5 surgeons and 5 sonologists)...
October 11, 2017: Ultrasound in Obstetrics & Gynecology
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