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https://www.readbyqxmd.com/read/29475047/are-3d-ultrasound-and-office-hysteroscopy-useful-for-the-assessment-of-uterine-cavity-after-late-foetal-loss
#1
Thellier Elise, Levaillant Jean-Marc, Pourcelot Anne-Gaëlle, Houllier Marie, Fernandez Hervé, Capmas Perrine
OBJECTIVE: To assess the efficacy of office hysteroscopy and 3D ultrasound for the diagnostic of uterine anomalies after late foetal loss. METHOD: This retrospective observational study took place in the gynaecologic unit of a teaching hospital from 2009 to 2014. Women with late foetal loss (< 22 weeks of gestation) had an office hysteroscopy and 3D ultrasound within 3 months after delivery. The results of the ultrasound and hysteroscopy were recorded and compared...
February 20, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29474743/csspl-functions-as-an-adaptor-between-hd-zip-iii-and-cswus-transcription-factors-regulating-anther-and-ovule-development-in-cucumber
#2
Xiaofeng Liu, Kang Ning, Gen Che, Shuangshuang Yan, Lijie Han, Ran Gu, Zheng Li, Yiqun Weng, Xiaolan Zhang
Anther and ovule genesis preconditions crop fertilization and fruit production. However, coordinative regulation of anther and ovule development and underlying molecular pathways remain largely elusive. Here, we found that SPOROCYTELESS (SPL)/NOZZLE (NZZ) expression was nearly abolished in a cucumber mutant with severely defective anther and ovule development. CsSPL was expressed specifically in the developing anthers and ovules. Knockdown of CsSPL reduced male and female fertility with malformed pollen and suppressed ovule development...
February 23, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29473997/extracellular-bone-morphogenetic-protein-modulator-bmper-and-twisted-gastrulation-homolog-1-preserve-arterial-venous-specification-in-zebrafish-blood-vessel-development-and-regulate-notch-signaling-in-endothelial-cells
#3
Jennifer Susanne Esser, Rahel Elisabeth Steiner, Meike Deckler, Hannah Schmitt, Bianca Engert, Sandra Link, Anne Charlet, Cam Patterson, Christoph Bode, Qian Zhou, Martin Moser
The bone morphogenetic protein (BMP) signaling pathway plays a central role during vasculature development. Mutations or dysregulation of the BMP pathway members have been linked to arteriovenous malformations. In the present study, we investigated the effect of the BMP modulators BMPER and twisted gastrulation protein homolog 1 (TWSG1) on arteriovenous specification during zebrafish development and analyzed downstream Notch signaling pathway in human endothelial cells. Silencing of bmper and twsg1b in zebrafish embryos by morpholinos resulted in a pronounced enhancement of venous ephrinB4a marker expression and concomitant dysregulated arterial ephrinb2a marker expression detected by in situ hybridization...
February 23, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29473522/an-evidence-based-review-of-off-label-uses-of-polidocanol
#4
Hossein Babaei, Elgar Enamzadeh
BACKGROUND: Polidocanol is approved for its competence in treatment of varicose veins and spider veins; however, unfortunately, many of its off-label uses are still underappreciated. OBJECTIVE: Lack of an appropriate comprehensive review for off-label uses of this medication troubles physicians about making evidence-based decisions on prescribing it for its various outstanding off-label uses. This article attempts to provide physicians with the latest information concerning successful and unsuccessful use of polidocanol as an alternative treatment for esophageal and gastric varices, tendinopathy and epicondylitis, vascular malformations, varicocele, hydrocele and spermatocele, aneurysmal bone cysts, itching, management of gastrointestinal bleeding, simple renal cysts, reducing the incidence and severity of radio-induced dermatitis, and hemorrhoids...
February 23, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29473152/white-matter-spongiosis-with-vigabatrin-therapy-for-infantile-spasms
#5
Phillip L Pearl, Annapurna Poduri, Sanjay P Prabhu, Chellamani Harini, Richard Goldstein, Richard M Atkinson, Dawna Armstrong, Hannah Kinney
The histopathology, "white matter spongiosis," defined by electron microscopy (EM) as "intramyelinic edema," has been associated with vigabatrin therapy in various animal models, but its role or significance in clinical studies is unknown. We conducted a neuropathological examination on a 27-month-old boy with bilateral polymicrogyria and epilepsy after sudden unexpected death in epilepsy (SUDEP). The patient was initiated on vigabatrin at 4 months of age, which controlled infantile spasms, and was continued as maintenance therapy...
February 23, 2018: Epilepsia
https://www.readbyqxmd.com/read/29472253/is-smoking-a-risk-factor-for-tinnitus-a-systematic-review-meta-analysis-and-estimation-of-the-population-attributable-risk-in-germany
#6
Annette Veile, Heiko Zimmermann, Eva Lorenz, Heiko Becher
OBJECTIVE: To assess the epidemiological association of smoking status and tinnitus with a systematic review and meta-analysis and to estimate the population attributable risk in Germany. DATA SOURCES: A systematic literature search in PubMed and ISI-Web of Science Core Collection resulted in 1026 articles that were indexed until 15 September 2015. Additionally, proceedings of the international tinnitus seminars and reference lists of relevant articles were screened...
February 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29471703/maternal-second-trimester-blood-levels-of-selected-heavy-metals-in-pregnancies-complicated-with-neural-tube-defects
#7
Şule Özel, Sebnem Ozyer, Osman Aykut, Mehmet Çinar, Omer Hınc Yılmaz, Ali Caglar, Yaprak Engin-Ustun
PURPOSE: Neural tube defects (NTDs) are the most common malformations of the central nervous system (CNS). There is continuing research for the identification of risk factors and interventions for prevention of NTDs. The aim of this study was to investigate the maternal second trimester blood levels of selected heavy metals namely, arsenic (As), cadmium (Cd), mercury (Hg), manganese (Mn), nickel (Ni), and lead (Pb) and their possible relation with the occurrence of NTDs. METHODS: Twenty-one healthy second trimester pregnant women with fetuses affected with NTD (cases) were matched with 21 healthy pregnant women with unaffected fetuses (controls) with respect to age, body mass index (BMI), and gestational age...
February 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29471258/outcomes-of-pregnancies-in-women-taking-antiepileptic-drugs-for-non-epilepsy-indications
#8
Dana Jazayeri, Janet Graham, Alison Hitchcock, Terence J O'Brien, Frank J E Vajda
PURPOSE: Antiepileptic drugs (AEDs), particularly valproate (VPA), are known to be teratogens when taken by women with epilepsy (WWE), but the risk in women who take these drugs for indications other than epilepsy have been little studied. This study aims to investigate the incidence of birth defects in children born to mothers taking AEDs for non-epilepsy indications. METHODS: The Australian Pregnancy Register (APR), established in 1998, is a prospective observational study operating with ethical approval and informed written consent for participation...
February 17, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29471168/developmental-toxicity-of-penconazole-in-zebrfish-danio-rerio-embryos
#9
Feyza Icoglu Aksakal, Abdulkadir Ciltas
Penconazole is a widely used fungicide that is toxic to a variety of organisms including fish. In the present study, we investigated the developmental toxicity of penconazole on zebrafish embryos by exposing to different concentrations of penconazole (0.8, 1.6 and 2.4 mg/L) from 4-h post-fertilization (hpf). Hatching, survival, and heart rates, body length, malformation and expression of several genes were detected. The results showed that penconazole exposure induced developmental toxicity, including delayed hatching, reduced survival, and heart rate...
February 17, 2018: Chemosphere
https://www.readbyqxmd.com/read/29470574/changes-in-scope-of-procedures-performed-by-pediatric-otolaryngologists-in-the-past-decade
#10
Alexandria L Irace, Catherine Shank, Eelam A Adil, Michael J Cunningham, Kosuke Kawai, Georgios Sideridis, Reza Rahbar
Importance: Monitoring current trends in pediatric otolaryngology will help adjust our training and practice paradigms in a way that ensures the long-term viability of the specialty. Objectives: To gauge the current scope of pediatric otolaryngology (ORL) practice within and outside of the United States and to identify changes in caseload over the past decade. Design, Setting, and Participants: An online survey was sent to pediatric ORL chairs and/or fellowship directors at 42 institutions in the United States and abroad...
February 22, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29470295/an-omental-lymphatic-malformation-mimicking-ascites-in-a-2-year-old-male
#11
Christopher Blackmore, Deborah Thompson, Johan Van Limbergen, Anthony Vandersteen, Rodrigo Romao
No abstract text is available yet for this article.
February 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29470256/systematic-screening-in-hereditary-hemorrhagic-telangiectasia-a-review
#12
Steven Kroon, Repke J Snijder, Marie E Faughnan, Hans-Jurgen Mager
PURPOSE OF REVIEW: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant inherited disease characterized by telangiectasia and arteriovenous malformations (AVMs). To date, five genetic types of HHT and one combined juvenile polyposis syndrome and HHT are known. Clinical and genetic screening of patients suspected with HHT is recommended to confirm the diagnosis and to prevent complications associated with HHT. The aim of this article is to give an overview of the evidence and to formulate a recommendation for clinicians concerning screening for HHT...
February 20, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29470234/incidence-of-neuraxial-abnormalities-is-approximately-8-among-patients-with-adolescent-idiopathic-scoliosis-a-meta-analysis
#13
Michael Faloon, Nikhil Sahai, Todd P Pierce, Conor J Dunn, Kumar Sinha, Ki Soo Hwang, Arash Emami
BACKGROUND: Several studies have sought to address the role of routine preoperative MRI in patients with adolescent idiopathic scoliosis (AIS) undergoing deformity correction. Despite similar results regarding the prevalence of neuraxial anomalies detected on MRI, published conclusions conflict and give opposing recommendations. Lack of consensus has led to important variations in use of MRI before spinal surgery for patients with AIS. QUESTIONS/PURPOSES: This systematic review and meta-analysis of studies about patients with AIS evaluated (1) the overall proportion of neuraxial abnormalities; (2) the patient factors and curve characteristics that may be associated with abnormalities; and (3) the proportion of patients who underwent neurosurgical intervention before scoliosis surgery and the kinds of neuraxial lesions that were identified...
February 21, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29469739/cowden-syndrome-clinical-case-and-a-brief-review
#14
Sofia Lopes, Julia Vide, Elisabete Moreira, Filomena Azevedo
Cowden syndrome is a rare genodermatosis of autosomal dominant inheritance characterized by multiple hamartomas in several organs and an increased risk of malignancies. We present the case of a 53-year-old man with a history of benign and malignant thyroid disease, intestinal polyposis, and Chiari malformation. He had several trichilemmomas, papillomatosis of the oral cavity, macular pigmentation of the glans penis, among other clinical features suggestive of Cowden syndrome. Given the suspicion, genetic study was conducted and PTEN mutation was identified...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469716/associated-conditions-in-patients-with-multiple-dermatofibromas-case-reports-and-literature-review
#15
Surget V Beatrous, Ryan R Riahi, Stratton B Grisoli, Philip R Cohen
Dermatofibromas are benign, fibrohistiocytic, dermal tumors. Solitary dermatofibromas may be incidental findings, whereas multiple dermatofibromas may be associated with systemic conditions or previous therapies. Two women and one man with multiple dermatofibromas and an associated systemic condition, immunosuppression, or both, are described. Nine dermatofibromas developed in a woman with hypothyroidism, optic neuritis, and Arnold Chiari I malformation. Five dermatofibromas developed in a woman with breast cancer who had received several systemic antineoplastic therapies...
September 22, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469668/review-of-de-novo-cerebral-arteriovenous-malformation-haemorrhage-risk-treatment-approaches-and-outcomes
#16
Xianli Lv, Guihuai Wang
Objective A small number of patients has been reported to develop a completely new or de novo arteriovenous malformation (AVM) after brain surgery, haemorrhage, head trauma or ischaemic stroke. The natural history of these lesions is unknown. In this review, both ruptured and unruptured de novo AVMs and their treatments were reviewed. Methods Published literature in the PubMed database citing 'de novo cerebral arteriovenous malformation' was reviewed. Additional studies were identified through reference searches in each reviewed article...
January 1, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/29468516/a-systematic-review-of-cognition-in-chiari-i-malformation
#17
REVIEW
Jeffrey M Rogers, Greg Savage, Marcus A Stoodley
Displacement of the cerebellar tonsils in Chiari type I malformation (CMI) can affect functions controlled by the cerebellum and brainstem. While playing an integral role in the control of movement, the cerebellum also has widespread cortical connections, influencing a range of cognitive process. A systematic literature review was conducted to examine the relationship between cognition and CMI, assessing evidence for general or domain-specific cognitive change. The search protocol examined the AMED, CINAHL, Cochrane Library, EMBASE, MEDLINE, PsycINFO, and Scopus databases...
February 21, 2018: Neuropsychology Review
https://www.readbyqxmd.com/read/29468291/lymphangiomatosis-a-rare-entity-presenting-with-involvement-of-the-sacral-plexus
#18
Megan K Mills, Bryn Putbrese, Hailey Allen, Sarah E Stilwill
Lymphangiomatosis is an uncommon disease process characterized by multisystem lymphatic malformations that can involve numerous body systems, including organs, muscles, soft tissues, and bones. Involvement of the nervous system is rare and has even been previously described as a site of sparing. We present a case of a 24-year-old female with known lymphangiomatosis, presenting with acute onset of lower extremity paresthesias, weakness, and new urinary retention. MRI of the pelvis revealed lymphangiomatosis of the sacral plexus, which has not been previously reported...
February 21, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29468267/a-congenital-accessory-skin-appendage-of-the-nasal-columella-and-nostril-sill-a-rare-anatomical-variation
#19
Yung Ki Lee, Young Hun Chung, Jin Sik Burm
PURPOSE: An accessory skin appendage of the nasal columella and nostril sill is an extremely rare congenital anatomical malformation; only a single case has been reported in the literature. However, no pathophysiology has been proposed. The purpose of this study is to present a review of the anatomical distribution of accessory skin appendages and provide a comprehensive review of their pathophysiology based on embryological development. METHODS: We present four cases of a protruding skin appendage of the nasal columella or nostril sill...
February 22, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29467628/anatomical-evidence-for-a-direct-projection-from-purkinje-cells-in-the-mouse-cerebellar-vermis-to-medial-parabrachial-nucleus
#20
Mitsuhiro Hashimoto, Akihiro Yamanaka, Shigeki Kato, Manabu Tanifuji, Kazuto Kobayashi, Hiroyuki Yaginuma
Cerebellar malformations cause changes to the sleep-wake cycle, resulting in sleep disturbance. However, it is unclear how the cerebellum contributes to the sleep-wake cycle. To examine the neural connections between the cerebellum and the nuclei involved in the sleep-wake cycle, we investigated the axonal projections of Purkinje cells in the mouse posterior vermis by using an adeno-associated virus (AAV) vector (serotype rh10) as an anterograde tracer. When an AAV vector expressing humanized renilla green fluorescent protein was injected into the cerebellar lobule IX, hrGFP and synaptophysin double-positive axonal terminals were observed in the region of medial parabrachial nucleus (MPB)...
2018: Frontiers in Neural Circuits
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