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https://www.readbyqxmd.com/read/27858115/-the-new-esc-guidelines-for-acute-and-chronic-heart-failure-2016
#1
C U Oeing, C Tschöpe, B Pieske
The new guidelines for the diagnosis and treatment of acute and chronic heart failure (HF) were presented in May 2016 during the congress of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in Florence. An important amendment affects the classification of HF which now differentiates between HF with preserved ejection fraction (HFpEF) and left ventricular EF (LVEF) > 50%, HF with reduced ejection fraction (HFrEF, LVEF < 40%) and the new entity HF with mid-range ejection fraction (HFmrEF, LVEF 40-49%)...
December 2016: Herz
https://www.readbyqxmd.com/read/27832556/can-femoral-venous-pressure-be-used-as-an-estimate-for-standard-vesical-intra-abdominal-pressure-measurement
#2
A E Howard, A Regli, E Litton, M M Malbrain, A-M Palermo, B L De Keulenaer
Intra-abdominal hypertension (IAH) is highly prevalent in critically ill patients admitted to the intensive care unit and is associated with an increased morbidity and mortality. The present study investigated whether femoral venous pressure (FVP) can be used as a surrogate parameter for intra-abdominal pressure (IAP) measured via the bladder in IAH grade II (IAP <20 mmHg) or grade III (IAP ≥20 mmHg). This was a single-centre prospective study carried out in a tertiary adult intensive care unit. IAP was measured via the bladder with a urinary catheter with simultaneous recording of the FVP via a femoral central line...
November 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27818720/registration-of-common-wheat-germplasm-with-mutations-in-sbeii-genes-conferring-increased-grain-amylose-and-resistant-starch-content
#3
André Schönhofen, Brittany Hazard, Xiaoqin Zhang, Jorge Dubcovsky
Starch present in the endosperm of common wheat (Triticum aestivum L.) grains is an important source of carbohydrates worldwide. Starches with a greater proportion of amylose have increased levels of resistant starch, a dietary fiber that can provide human health benefits. Induced mutations in STARCH BRANCHING ENZYME II (SBEII) genes in wheat are associated with increased amylose and resistant starch. Ethyl methane sulfonate mutations in SBEIIa and SBEIIb paralogs were combined in the hexaploid wheat cultivar Lassik...
May 2016: Journal of Plant Registrations
https://www.readbyqxmd.com/read/27678500/applications-and-mechanisms-of-immunotherapy-in-allergic-rhinitis-and-asthma
#4
Jasper H Kappen, Stephen R Durham, Hans In 't Veen, Mohamed H Shamji
Clinical and immunologic tolerance are hallmarks of successful allergen immunotherapy (AIT). Clinical benefits such as reduced symptoms, pharmacotherapy intake and improvement of quality of life persist following cessation of treatment. Successful AIT is associated with suppression of allergic inflammatory cells such as mast cells, eosinophils and basophils in target organs. Furthermore, AIT down-regulates type 2 innate lymphoid cells and allergen-specific type 2 T-helper (Th2) cells. The immunologic tolerant state following AIT is associated with the induction of distinct phenotypes of regulatory T-cells (T-regs) including interleukin (IL)-10-, IL-35- and transforming growth factor (TGF)-β- producing T-regs and FoxP3(+) T-regs...
September 27, 2016: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/27602966/cosmetic-use-of-abobotulinumtoxina-in-men-considerations-regarding-anatomical-differences-and-product-characteristics
#5
Jason D Bloom, Jeremy B Green, Whitney Bowe, Erika von Grote, Alessandra Nogueira
The proportion of men seeking facial rejuvenation with botulinum neurotoxin type A (BoNTA) products is increasing. The number of male patients treated in the 5-year period between 2009 and 2014 grew by 25%. There is little clinical data supporting gender-specific efficacy with regard to dosing and injection placement in men. To nurture the confidence associated with treatment of male patients, clinicians are in need of more informational materials to develop their evaluation and treatment strategies. Three BoNTA products are currently available in the United States (US) for treatment of the upper face...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27554813/probiotic-supplementation-has-little-effect-on-peripheral-blood-regulatory-t%C3%A2-cells
#6
Nicholas P West, Peggy L Horn, David B Pyne, Hilary S Warren, Suzanne Asad, Amanda J Cox, Sampo J Lahtinen, Markus J Lehtinen, Peter A Fricker, Allan W Cripps, Barbara Fazekas de St Groth
No abstract text is available yet for this article.
August 20, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27526711/exogenous-tnfr2-activation-protects-from-acute-gvhd-via-host-t-reg-cell-expansion
#7
Martin Chopra, Marlene Biehl, Tim Steinfatt, Andreas Brandl, Juliane Kums, Jorge Amich, Martin Vaeth, Janina Kuen, Rafaela Holtappels, Jürgen Podlech, Anja Mottok, Sabrina Kraus, Ana-Laura Jordán-Garrote, Carina A Bäuerlein, Christian Brede, Eliana Ribechini, Andrea Fick, Axel Seher, Johannes Polz, Katja J Ottmüller, Jeanette Baker, Hidekazu Nishikii, Miriam Ritz, Katharina Mattenheimer, Stefanie Schwinn, Thorsten Winter, Viktoria Schäfer, Sven Krappmann, Hermann Einsele, Thomas D Müller, Matthias J Reddehase, Manfred B Lutz, Daniela N Männel, Friederike Berberich-Siebelt, Harald Wajant, Andreas Beilhack
Donor CD4(+)Foxp3(+) regulatory T cells (T reg cells) suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (HCT [allo-HCT]). Current clinical study protocols rely on the ex vivo expansion of donor T reg cells and their infusion in high numbers. In this study, we present a novel strategy for inhibiting GvHD that is based on the in vivo expansion of recipient T reg cells before allo-HCT, exploiting the crucial role of tumor necrosis factor receptor 2 (TNFR2) in T reg cell biology...
August 22, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27523950/cytokine-gene-expression-in-aborting-and-non-aborting-dams-and-in-their-foetuses-after-experimental-infection-with-neospora-caninum-at-110-days-of-gestation
#8
S Almeria, B Serrano-Pérez, L Darwich, R Mur-Novales, I Garcia-Ispierto, O Cabezón, F López-Gatius
Neospora caninum is a major cause of abortion in cattle. However, it is not known why not all infected animals abort. In this study, Th1 (IFN-γ), Th2 (IL4) and T reg (IL-10) cytokine gene expression was examined by real time PCR using the TaqMan approach in all of these dams and their foetuses after experimental infection with the isolate Nc-Spain7 at 110 days of pregnancy and euthanasia 6 weeks after infection. In prior published work, foetal death was observed in three of six infected dams and transplacental infection in all the 6 infected foetuses...
August 30, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27508639/-op-2d-04-perivascular-t-regulatory-cells-and-endothelial-dysfunction-in-human-atherosclerosis
#9
K Urbanski, G Filip, M Filip, D Ludew, P Szczepaniak, R Nosalski, A Sagan, T Mikolajczyk, B Kapelak, T J Guzik
OBJECTIVE: Atherosclerosis is an inflammatory disease associated with an imbalance between pro- and anti-inflammatory mechanisms. While ample evidence is available in animal models, less is known about links between local vascular inflammation in human disease. T regulatory cells (Treg) have been implicated in atherosclerosis in mice but links with human vascular inflammation are poorly understood. Accordingly, we aimed to investigate the relationship between T regs in peripheral blood and locally in perivascular adipose tissue (pVAT) with endothelial function as a key mechanism in pathogenesis of vascular disease...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27477798/fluorescence-versus-x-ray-cholangiography-during-laparoscopic-cholecystectomy-protocol-for-a-randomised-trial
#10
Lars Lang Lehrskov, Søren S Larsen, Billy B Kristensen, Thue Bisgaard
INTRODUCTION: Intraoperative fluorescent cholangiography is a novel non-invasive imaging technique to visualise the extrahepatic biliary tract during laparoscopic cholecystectomy. It has been proven feasible, fast and cost effective. Never-theless, there is only sparse data on the capacity of fluorescent cholangiography to visualise the biliary anatomy. METHODS: Based on a non-inferiority design, patients with complicated gallstone disease are randomised to either -intraoperative conventional X-ray cholangiography (reference group, n = 60) or intraoperative fluorescent cholangiography (n = 60)...
August 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27467951/regulatory-b-lymphocyte-functions-should-be-considered-in-chronic-lymphocytic-leukemia
#11
REVIEW
Audrey Mohr, Yves Renaudineau, Cristina Bagacean, Jacques-Olivier Pers, Christophe Jamin, Anne Bordron
Chronic lymphocytic leukemia (CLL) is characterized by an abnormal expansion of mature B cells in the bone marrow and their accumulation in blood and secondary lymphoid organs. Tumor CLL cells share expression of various surface molecules with many subsets of B cells and have several common characteristics with regulatory B cells (B regs). However, the identification of B regs and their role in CLL remain elusive. The aim of this review is to summarize recent works regarding the regulatory and phenotypic characteristic of B regs and their associated effects on the immune system...
May 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27437104/b-cell-regulation-of-the-anti-tumor-response-and-role-in-carcinogenesis
#12
REVIEW
Marc Schwartz, Yu Zhang, Joseph D Rosenblatt
The balance between immune effector cells such as T cells and natural killer cells, and immunosuppressive Treg cells, dendritic, myeloid and monocytic sub-populations in the tumor microenvironment acts to calibrate the immune response to malignant cells. Accumulating evidence is pointing to a role for B cells in modulating the immune response to both solid tumors and hematologic cancer. Evidence from murine autoimmune models has defined B regulatory cell (Breg) subsets that express cytokines such as IL-10, TGF-β, and/or express immune regulatory ligands such as PD-L1, which can suppress T cell and/or natural killer cell responses...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27285924/technical-note-prediction-of-chemical-rib-section-composition-by-dual-energy-x-ray-absorptiometry-in-zebu-beef-cattle
#13
L F Prados, D Zanetti, P M Amaral, L D S Mariz, D F T Sathler, S C Valadares Filho, F F Silva, B C Silva, M C Pacheco, H M Alhadas, M L Chizzotti
It is expensive and laborious to evaluate carcass composition in beef cattle. The objective of this study was to evaluate a method to predict the 9th to 11th rib section (rib) composition through empirical equations using dual energy X-ray absorptiometry (DXA). Dual energy X-ray absorptiometry is a validated method used to describe tissue composition in humans and other animals, but few studies have evaluated this technique in beef cattle, and especially in the Zebu genotype. A total of 116 rib were used to evaluate published prediction equations for rib composition and to develop new regression models using a cross-validation procedure...
June 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27230380/gene-microbiota-interactions-contribute-to-the-pathogenesis-of-inflammatory-bowel-disease
#14
Hiutung Chu, Arya Khosravi, Indah P Kusumawardhani, Alice H K Kwon, Anilton C Vasconcelos, Larissa D Cunha, Anne E Mayer, Yue Shen, Wei-Li Wu, Amal Kambal, Stephan R Targan, Ramnik J Xavier, Peter B Ernst, Douglas R Green, Dermot P B McGovern, Herbert W Virgin, Sarkis K Mazmanian
Inflammatory bowel disease (IBD) is associated with risk variants in the human genome and dysbiosis of the gut microbiome, though unifying principles for these findings remain largely undescribed. The human commensal Bacteroides fragilis delivers immunomodulatory molecules to immune cells via secretion of outer membrane vesicles (OMVs). We reveal that OMVs require IBD-associated genes, ATG16L1 and NOD2, to activate a noncanonical autophagy pathway during protection from colitis. ATG16L1-deficient dendritic cells do not induce regulatory T cells (T(regs)) to suppress mucosal inflammation...
May 27, 2016: Science
https://www.readbyqxmd.com/read/27184362/global-changes-in-the-proteome-of-cupriavidus-necator-h16-during-poly-3-hydroxybutyrate-synthesis-from-various-biodiesel-by-product-substrates
#15
Parveen K Sharma, Jilagamazhi Fu, Victor Spicer, Oleg V Krokhin, Nazim Cicek, Richard Sparling, David B Levin
Synthesis of poly-[3-hydroxybutyrate] (PHB) by Cupriavidus necator H16 in batch cultures was evaluated using three biodiesel-derived by-products as the sole carbon sources: waste glycerol (REG-80, refined to 80 % purity with negligible free fatty acids); glycerol bottom (REG-GB, with up to 65 % glycerol and 35 % free fatty acids), and free fatty acids (REG-FFA, with up to 75 % FFA and no glycerol). All the three substrates supported growth and PHB production by C. necator, with polymer accumulation ranging from 9 to 84 % cell dry weight (cdw), depending on the carbon source...
December 2016: AMB Express
https://www.readbyqxmd.com/read/27167273/evaluation-of-the-tool-reg-refine-for-user-guided-deformable-image-registration
#16
Perry B Johnson, Kyle R Padgett, Kuan L Chen, Nesrin Dogan
"Reg Refine" is a tool available in the MIM Maestro v6.4.5 platform (www.mim-software.com) that allows the user to actively participate in the deformable image registration process. The purpose of this work was to evaluate the efficacy of this tool and investigate strategies for how to apply it effectively. This was done by performing DIR on two publicly available ground-truth models, the Pixel-based Breathing Thorax Model (POPI) for lung, and the Deformable Image Registration Evaluation Project (DIREP) for head and neck...
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27166142/extra-hepatic-infection-of-hepatitis-c-virus-in-the-colon-tissue-and-its-relationship-with-hepatitis-c-virus-pathogenesis
#17
Helal F Hetta, Mohamed A Mekky, Nasr K Khalil, Wegdan A Mohamed, Mohamed A El-Feky, Shabaan H Ahmed, Enas A Daef, Ahmed Medhat, Mahmoud I Nassar, Kenneth E Sherman, Mohamed Tarek M Shata
Extra-hepatic compartments might contribute to hepatitis C virus (HCV) persistence and extra-hepatic manifestations. Therefore, we investigated HCV infection in colonic tissue in patients with chronic hepatitis C (CHC) and its relationship with HCV pathogenesis. Colonic biopsies were collected from three groups with CHC infection: treatment naïve (TN; n=12), non-responders (NR; n=10) to anti-HCV therapy (pegylated interferon-α and ribavirin) and sustained virologic response (SVR; n=10) and from a fourth healthy control group (n=10)...
August 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27148256/suppression-of-hiv-replication-by-cd8-regulatory-t-cells-in-elite-controllers
#18
Wei Lu, Song Chen, Chunhui Lai, Mingyue Lai, Hua Fang, Hong Dao, Jun Kang, Jianhua Fan, Weizhong Guo, Linchun Fu, Jean-Marie Andrieu
We previously demonstrated in the Chinese macaque model that an oral vaccine made of inactivated SIV and Lactobacillus plantarum induced CD8(+) regulatory T-cells, which suppressed the activation of SIV(+)CD4(+) T-cells, prevented SIV replication, and protected macaques from SIV challenges. Here, we sought whether a similar population of CD8(+) T-regs would induce the suppression of HIV replication in elite controllers (ECs), a small population (3‰) of HIV-infected patients with undetectable HIV replication...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27085566/prevention-of-urinary-tract-infection-with-oximacro-a-cranberry-extract-with-a-high-content-of-a-type-proanthocyanidins-a-pre-clinical-double-blind-controlled-study
#19
Andrea Occhipinti, Antonio Germano, Massimo E Maffei
PURPOSE: Urinary tract infections (UTIs) are widespread and affect a large portion of the human population. Cranberry juices and extracts have been used for UTI prevention due to their content of bioactive proanthocyanidins (PACs), particularly of the A type (PAC-A). Controversial clinical results obtained with cranberry are often due to a lack of precise determination and authentication of the PAC-A content. This study used Oximacro (Biosfered S.r.l., Turin, Italy), a cranberry extract with a high content of PAC-A, to prevent UTIs in female and male volunteers...
March 2016: Urology Journal
https://www.readbyqxmd.com/read/27061233/trans-11-vaccenic-acid-improves-insulin-secretion-in-models-of-type-2-diabetes-in-vivo-and-in-vitro
#20
Xiaofeng Wang, Joel Gupta, Matthew Kerslake, Gina Rayat, Spencer D Proctor, Catherine B Chan
SCOPE: Trans-11 vaccenic acid (VA) is a fatty acid produced by ruminants entering the human food supply through meat and dairy products, which appears not to have the health risks associated with industrially produced trans-fatty acids. In this study, we investigated the effect of VA on insulin secretion in vivo in rats and in vitro in human and rat islets after diabetogenic insult. METHODS AND RESULTS: Hyperglycemic clamp showed that VA dietary supplementation for 8 weeks significantly increased glucose turnover in rats with type 2 diabetes (T2D), accompanied by an elevated plasma C-peptide concentration, indicating improved insulin secretion...
April 2016: Molecular Nutrition & Food Research
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