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Cigarette AND morbidity

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https://www.readbyqxmd.com/read/29025711/toll-like-receptor-2-and-4-have-opposing-roles-in-the-pathogenesis-of-cigarette-smoke-induced-chronic-obstructive-pulmonary-disease
#1
Tatt Jhong Haw, Malcolm R Starkey, Stelios Pavlidis, Michael Fricker, Anya L Arthurs, Prema Mono Nair, Gang Liu, Irwan Hanish, Richard Y Kim, Paul S Foster, Jay C Horvat, Ian M Adcock, Philip M Hansbro
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of morbidity and death and imposes major socioeconomic burdens globally. It is a progressive and disabling condition that severely impairs breathing and lung function. There is a lack of effective treatments for COPD, which is a direct consequence of the poor understanding of the underlying mechanisms involved in driving the pathogenesis of the disease. Toll-like receptor (TLR)2 and TLR4 are implicated in chronic respiratory diseases, including COPD, asthma and pulmonary fibrosis...
October 12, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28992538/health-lifestyles-across-the-transition-to-adulthood-implications-for-health
#2
Elizabeth M Lawrence, Stefanie Mollborn, Robert A Hummer
Research has long established the importance of individual health behaviors such as cigarette smoking for adult morbidity and mortality. However, we know little about how health behaviors cluster into health lifestyles among adolescents and young adults in the United States, or in turn, how such health lifestyles are associated with young adult health outcomes. This study establishes health lifestyles as distinct group phenomena at three developmental time points in a single cohort: late adolescence (ages 15-17), early adulthood (ages 20-24), and young adulthood (ages 26-31)...
September 23, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28983580/laparoscopic-sleeve-gastrectomy-for-morbidly-obese-adolescents-in-singapore
#3
Dallan Dargan, Dmitrii Dolgunov, Khin Thida Soe, Pamela Er, Fathimath Naseer, Davide Lomanto, Jimmy By So, Asim Shabbir
INTRODUCTION: Laparoscopic sleeve gastrectomy (LSG) outcomes among adolescents and adolescent obesity associated factors in Singapore were evaluated. METHODS: Prospectively collected data of patients aged 16-19 years at first presentation who underwent LSG was retrospectively reviewed. A questionnaire was completed incorporating cigarette, alcohol, dietary and exercise habits; family history of obesity; Berlin and Epworth scores; and Patient Health Questionnaire-9 (PHQ-9) scores...
October 6, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28955435/exposure-to-biomass-smoke-as-a-risk-factor-for-oesophageal-and-gastric-cancer-in-low-income-populations-a-systematic-review
#4
REVIEW
Violet Kayamba, Douglas C Heimburger, Douglas R Morgan, Masharip Atadzhanov, Paul Kelly
BACKGROUND: Upper gastrointestinal cancers contribute significantly to cancer-related morbidity and mortality in sub-Saharan Africa, but they continue to receive limited attention. The high incidence in young adults remains unexplained, and the risk factors have not been fully described. METHODS: A literature search was conducted using the electronic database PubMed. Beginning from January 1980 to February 2016, all articles evaluating biomass smoke exposure with oesophageal and gastric cancer were reviewed...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28950428/cigarette-smoking-significantly-alters-sperm-dna-methylation-patterns
#5
T G Jenkins, E R James, D F Alonso, J R Hoidal, P J Murphy, J M Hotaling, B R Cairns, D T Carrell, K I Aston
Numerous health consequences of tobacco smoke exposure have been characterized, and the effects of smoking on traditional measures of male fertility are well described. However, a growing body of data indicates that pre-conception paternal smoking also confers increased risk for a number of morbidities on offspring. The mechanism for this increased risk has not been elucidated, but it is likely mediated, at least in part, through epigenetic modifications transmitted through spermatozoa. In this study, we investigated the impact of cigarette smoke exposure on sperm DNA methylation patterns in 78 men who smoke and 78 never-smokers using the Infinium Human Methylation 450 beadchip...
September 26, 2017: Andrology
https://www.readbyqxmd.com/read/28942562/abnormal-levels-of-vascular-endothelial-biomarkers-in-schizophrenia
#6
Tanya T Nguyen, Sheena I Dev, Guanqing Chen, Sharon C Liou, Averria Sirkin Martin, Michael R Irwin, Judith E Carroll, Xin Tu, Dilip V Jeste, Lisa T Eyler
Schizophrenia is associated with chronic low-grade inflammation, which has been linked to increased vascular risk and rates of cardiovascular disease. Levels of vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) have been related to aging and neurodegeneration, but their role in schizophrenia remains uncertain. Using a cross-sectional, case-control design, this study included 99 outpatients with schizophrenia and 99 healthy comparison subjects (HCs)...
September 23, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28937573/committee-opinion-no-721-smoking-cessation-during-pregnancy
#7
(no author information available yet)
Smoking is the one of the most important modifiable causes of poor pregnancy outcomes in the United States, and is associated with maternal, fetal, and infant morbidity and mortality. The physical and psychologic addiction to cigarettes is powerful; however, the compassionate intervention of the obstetrician-gynecologist can be the critical element in prenatal smoking cessation. An office-based protocol that systematically identifies pregnant women who smoke and offers treatment or referral has been proved to increase quit rates...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937568/committee-opinion-no-721-summary-smoking-cessation-during-pregnancy
#8
(no author information available yet)
Smoking is the one of the most important modifiable causes of poor pregnancy outcomes in the United States, and is associated with maternal, fetal, and infant morbidity and mortality. The physical and psychologic addiction to cigarettes is powerful; however, the compassionate intervention of the obstetrician-gynecologist can be the critical element in prenatal smoking cessation. An office-based protocol that systematically identifies pregnant women who smoke and offers treatment or referral has been proved to increase quit rates...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28935057/no-349-substance-use-in-pregnancy
#9
Alice Ordean, Suzanne Wong, Lisa Graves
OBJECTIVES: To improve awareness and knowledge of problematic substance use in pregnancy and to provide evidence-based recommendations for the management of this challenging clinical issue for all health care providers. OPTIONS: This guideline reviews the use of screening tools, general approach to care, and recommendations for the clinical management of problematic substance use in pregnancy. OUTCOMES: Evidence-based recommendations for screening and management of problematic substance use during pregnancy and lactation...
October 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28910267/surveillance-for-certain-health-behaviors-and-conditions-among-states-and-selected-local-areas-behavioral-risk-factor-surveillance-system-united-states-2013-and-2014
#10
Sonya Gamble, Tebitha Mawokomatanda, Fang Xu, Pranesh P Chowdhury, Carol Pierannunzi, David Flegel, William Garvin, Machell Town
PROBLEM: Chronic diseases and conditions (e.g., heart diseases, stroke, arthritis, and diabetes) are the leading causes of morbidity and mortality in the United States. These conditions are costly to the U.S. economy, yet they are often preventable or controllable. Behavioral risk factors (e.g., excessive alcohol consumption, tobacco use, poor diet, frequent mental distress, and insufficient sleep) are linked to the leading causes of morbidity and mortality. Adopting positive health behaviors (e...
September 15, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28904914/novel-cardiovascular-risk-markers-in-nigerian-cigarette-smokers
#11
Godwin O Adunmo, AbdulFatah Ayoade Adesokan, Olufemi Olumuyiwa Desalu, Sikiru Abayomi Biliaminu, Eyitayo O Adunmo
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. While the effect of cigarette smoking on conventional markers that account for <50% of CVD s has been well studied, there are only a few studies on the effect of cigarette smoking on novel cardiovascular (CV) risk markers. OBJECTIVE: To evaluate the effect of cigarette smoking on the novel CV markers such as homocysteine (HCY), lipoprotein (a) (Lp(a)), and C-reactive protein (CRP)...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28865477/rig-i-overexpression-decreases-mortality-of-cigarette-smoke-exposed-mice-during-influenza-a-virus-infection
#12
Xiaoqiu Wang, Wenxin Wu, Wei Zhang, J Leland Booth, Elizabeth S Duggan, Lili Tian, Sunil More, Yan D Zhao, Ravindranauth N Sawh, Lin Liu, Ming-Hui Zou, Jordan P Metcalf
BACKGROUND: Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines which participate in clearing viral infections. Cigarette smoke (CS) exposure increases the frequency and severity of respiratory tract infections. METHODS: We generated a RIG-I transgenic (TG) mouse strain that expresses the RIG-I gene product under the control of the human lung specific surfactant protein C promoter...
September 2, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28841089/intimate-partner-violence-small-for-gestational-age-birth-and-cigarette-smoking-in-the-pregnancy-risk-assessment-monitoring-system
#13
Jeanne L Alhusen, Ruth Geller, Jerry Jellig, Chakra Budhathoki, Michele Decker
BACKGROUND: Exposure to intimate partner violence (IPV) in the perinatal period is associated with obstetric complications, poor maternal mental health, neonatal complications, and increased risk of infant mortality and morbidity. Less is known about how IPV may influence small for gestational age (SGA) birth. MATERIALS AND METHODS: Data were obtained for 231,081 United States mothers who delivered neonates from 2004 to 2011 and completed the Pregnancy Risk Assessment Monitoring System survey 2-9 months after delivery...
August 25, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28820539/a-survey-of-non-communicable-diseases-and-their-risk-factors-among-university-employees-a-single-institutional-study
#14
Emmanuel I Agaba, Maxwell O Akanbi, Patricia A Agaba, Amaka N Ocheke, Zumnan M Gimba, Steve Daniyam, Edith N Okeke
BACKGROUND: The incidence of non-communicable diseases (NCDs) is rising globally, with its attendant morbidity and mortality, especially in developing countries. This study evaluated the prevalence of NCDs and their risk factors among members of a university community. METHODS: All employees of the university were invited to the University health clinic for screening, using the World Health Organisation's STEPwise approach to NCDs. RESULTS: A total of 883 (521; 59...
August 15, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28802571/omega-3-polyunsaturated-fatty-acids-improve-endothelial-function-in-humans-at-risk-for-atherosclerosis-a-review
#15
REVIEW
Kayla R Zehr, Mary K Walker
Epidemiology studies and clinical trials show that omega-3 polyunsaturated fatty acids (n-3 PUFAs) can prevent atherosclerotic morbidity and evidence suggests this may be mediated by improving endothelial dysfunction. Endothelial dysfunction is characterized by reduced vasodilation and a pro-inflammatory, pro-thrombotic state, and is an early pathological event in the development of atherosclerosis. Flow-mediated dilation (FMD), a gold standard for assessing endothelial dysfunction, is a predictor of future cardiovascular events and coronary heart disease risk...
August 9, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28762312/cadmium-organ-toxicity-and-therapeutic-approaches-a-review-on-brain-kidney-and-testis-damage
#16
Mariagrazia Rinaldi, Antonio Micali, Herbert Marini, Elena Bianca Adamo, Domenico Puzzolo, Antonina Pisani, Vincenzo Trichilo, Domenica Altavilla, Francesco Squadrito, Letteria Minutoli
BACKGROUND: Cadmium (Cd) is a heavy metal particularly hazardous for human health, as it is highly diffused and, therefore, a ubiquitous environmental toxicant. In fact, in the general population, the main sources of exposure are food, cigarette smoking, inhalation of ambient air, drinking water, contaminated soil or dust. Furthermore, an occupational exposure usually involves human during mining, fume inhalation or manufacturing nickel-cadmium battery, electroplating and paint pigments that utilize Cd...
August 1, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28759510/cerebellar-stroke-a-missed-diagnosis
#17
Diane C Berry, Amber Rafferty, Kathleen Tiu, Timothy F Platt-Mills
Cerebellar strokes account for less than 10% of all strokes but lead to significantly poor outcomes. Cerebellar strokes that are initially missed have a mortality rate of 40%, and half of the patients who survive have long-term deficits. The patient's history may provide clues that point to a cerebellar stroke. Signs and symptoms include vertigo, headache, vomiting and ataxia. It is important to note the presence of stroke risk factors, such as a history of strokes or transient ischemic attacks, diabetes mellitus, hypertension, hypercholesterolemia, advanced age, atrial fibrillation, and cigarette smoking...
July 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/28743683/cross-sectional-study-of-chronic-obstructive-pulmonary-disease-prevalence-among-smokers-ex-smokers-and-never-smokers-in-almaty-kazakhstan-study-protocol
#18
Almaz Sharman, Baurzhan Zhussupov, Dana Sharman, Assel Stambekova, Sattar Yeraliyev
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is significantly underdiagnosed in Kazakhstan, and there is no previously conducted study on COPD prevalence in the country. OBJECTIVE: The purpose of this study is to assess the prevalence of COPD among individuals aged 40 to 59 years based on results of spirometry before and after bronchodilator, presence of structural changes in the lungs (emphysema, inflammatory changes, and thickening of the walls of the large and small airways) detected by computer tomography, and the symptoms of COPD...
July 25, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28735272/perceived-nicotine-content-of-reduced-nicotine-content-cigarettes-is-a-correlate-of-perceived-health-risks
#19
Lauren R Pacek, F Joseph McClernon, Rachel L Denlinger-Apte, Melissa Mercincavage, Andrew A Strasser, Sarah S Dermody, Ryan Vandrey, Tracy T Smith, Natalie Nardone, Dorothy K Hatsukami, Joseph S Koopmeiners, Rachel V Kozink, Eric C Donny
BACKGROUND: Reducing cigarette nicotine content may reduce smoking. Studies suggest that smokers believe that nicotine plays a role in smoking-related morbidity. This may lead smokers to assume that reduced nicotine means reduced risk, and attenuate potential positive effects on smoking behaviour. METHODS: Data came from a multisite randomised trial in which smokers were assigned to use cigarettes varying in nicotine content for 6 weeks. We evaluated associations between perceived and actual nicotine content with perceived health risks using linear regression, and associations between perceived nicotine content and perceived health risks with smoking outcomes using linear and logistic regression...
July 22, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28725319/autologous-stromal-vascular-fraction-in-the-intravenous-treatment-of-end-stage-chronic-obstructive-pulmonary-disease-a-phase-i-trial-of-safety-and-tolerability
#20
Kristin Comella, Jesus A Perez Blas, Tom Ichim, Javier Lopez, Jose Limon, Ruben Corral Moreno
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a consistently progressive, ultimately fatal disease for which no treatment exists capable of either reversing or even interrupting its course. It afflicts more than 5% of the population in many countries, and it accordingly represents the third most frequent cause of death in the US, where it accounts for more than 600 billion in health care costs, morbidity, and mortality. Adipose tissue contains within its stromal compartment a high abundance of adipose stem/stromal cells (ASCs), which can be readily separated from the adipocyte population by methods which require less than 2 h of processing time and yield a concentrated cellular preparation termed the stromal vascular fraction (SVF)...
August 2017: Journal of Clinical Medicine Research
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