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Jaromir Jarda Ruzicka
Automation of reagent based assays, by means of Flow Injection (FI), is based on sample processing, in which a sample flows continuously towards and through a detector for quantification of the target analyte. The Achilles heel of this methodology, the legacy of Auto Analyzer®, is continuous reagent consumption, and continuous generation of chemical waste. However, flow programming, assisted by recent advances in precise pumping, combined with the lab-on-valve technique, allows the FI manifold to be designed around a single confluence point through which sample and reagents are sequentially directed by means of a series of flow reversals...
January 1, 2018: Talanta
Stathis Antoniou, Sofia Lambropoulou
Topological surgery is a mathematical technique used for creating new manifolds out of known ones. We observe that it occurs in natural phenomena where a sphere of dimension 0 or 1 is selected, forces are applied and the manifold in which they occur changes type. For example, 1-dimensional surgery happens during chromosomal crossover, DNA recombination and when cosmic magnetic lines reconnect, while 2-dimensional surgery happens in the formation of tornadoes, in the phenomenon of Falaco solitons, in drop coalescence and in the cell mitosis...
2017: PloS One
Mariusz P Furmanek, Stanisław Solnik, Daniele Piscitelli, Omid Rasouli, Ali Falaki, Mark L Latash
The authors used two analyses developed within the framework of the uncontrolled manifold hypothesis to quantify multimuscle synergies during voluntary body sway: analysis of intertrial variance and analysis of motor equivalence with respect to the center of pressure (COP) trajectory. Participants performed voluntary sway tasks in the anteroposterior direction at 0.33 and 0.66 Hz. Muscle groups were identified in the space of muscle activations and used as elemental variables in the synergy analyses. Changing mechanical and vision feedback-based constraints led to significant changes in indices of sway performance such as COP deviations in the uninstructed, mediolateral direction and indices of spontaneous postural sway...
September 15, 2017: Journal of Motor Behavior
Cheng-Qiang Wang, Yu Zhang, Chao Feng
An unprecedented Rh(III)-catalyzed hydroarylation of α,α-difluoromethylene alkynes with N-pivaloxyl aroylamides through sequential C-H activation and aryl migration was detailed herein. A large array of α,α-difluoromethylene alkynes and N-pivaloxyl aroylamides were well amenable to this transformation, thus providing a novel synthetic protocol for the construction of difluorinated 2-alkenylaniline derivatives in both high yields and excellent regioselectivity. Also of note, the unique fluorine effects were uncovered to underlie the thus unconventional reaction manifold...
September 15, 2017: Angewandte Chemie
Heeseon Lim, Hyuksang Kwon, Sang Kyu Kim, Jeong Won Kim
Light absorption in organic molecules on an inorganic substrate and subsequent electron transfer to the substrate create so-called hybrid charge transfer exciton (HCTE). The relaxation process of the HCTE states largely determines charge separation efficiency or optoelectronic device performance. Here, the study on energy and time-dispersive behavior of photoelectrons at the hybrid interface of copper phthalocyanine (CuPc)/p-GaAs(001) upon light excitation of GaAs reveals a clear pathway for HCTE relaxation and delayed triplet formation...
September 15, 2017: Journal of Physical Chemistry Letters
Satoshi Okamoto, Masayuki Ochi, Ryotaro Arita, Jiaqiang Yan, Nandini Trivedi
Electron correlations tend to generate local magnetic moments that usually order if the lattices are not too frustrated. The hexagonal compound SrRu2O6 has a relatively high Neel temperature but small local moments, which seem to be at odds with the nominal valence of Ru(5+) in the [Formula: see text] configuration. Here, we investigate the electronic property of SrRu2O6 using density functional theory (DFT) combined with dynamical-mean-field theory (DMFT). We find that the strong hybridization between Ru d and O p states results in a Ru valence that is closer to +4, leading to the small ordered moment ~1...
September 13, 2017: Scientific Reports
Sasha Reschechtko, Mark L Latash
We combined the theory of neural control of movement with referent coordinates and the uncontrolled manifold hypothesis to explore synergies stabilizing the hand action in accurate four-finger pressing tasks. In particular, we tested a hypothesis on two classes of synergies - those among the four fingers and those within a pair of control variables - stabilizing hand action under visual feedback and disappearing without visual feedback. Subjects performed four-finger total force and moment production tasks under visual feedback; the feedback was later partially or completely removed...
September 13, 2017: Journal of Neurophysiology
Daniele Fazzi, Mario Barbatti, Walter Thiel
The evolution of the excited-state manifold in organic D/A aggregates (e.g. the prototypical P3HT/PCBM) is investigated through a bottom-up approach via first-principles calculations. We show how the excited-state energies, the charge transfer (CT) states, and the electron-hole density distributions are strongly influenced by the size, the orientation and the position (i.e. on-top vs. on-edge phases) of P3HT/PCBM domains. We discuss how the structural order influences the excited-state electronic structure, providing an atomistic interpretation of the photophysics of organic blends...
September 13, 2017: Journal of Physical Chemistry Letters
Phani Kumar, Torben Rogge, Santhivardhana Reddy Yetra, Alexander Bechtholdt, Eric Clot, Lutz Ackermann
Computational studies on decarboxylative C-H alkenylations provided key insights into the solvent-independent nature of C-H activation/decarboxylation domino reactions, which was exploited for ruthenium(II)-catalyzed C-H alkylations by decarboxylative ruthenium(II) catalysis with ample scope under copper- and silver-free reaction conditions.
September 12, 2017: Chemistry: a European Journal
Ron Kimmel
No abstract text is available yet for this article.
September 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
Joachim Cauwe, Stijn Vanheule, Mattias Desmet
Transference implies the actualization of the analyst in the analytic encounter. Lacan developed this idea through the syntagm presence of the analyst. In the course of his seminars, however, two completely different presences emerge, with major implications for how the treatment is directed. In the light of Lacan's idea that the transference is constituted in Real, Symbolic, and Imaginary dimensions, it can be seen how in his early work the analyst's presence is a phenomenon at the crossroads between signifiers and images...
August 2017: Journal of the American Psychoanalytic Association
Nina Tonn, Thomas Greb
One of the extraordinary features of plants is their growth capacity. Depending on the species and the environment, body forms are manifold and, at the same time, constantly reshaped. An important basis of this plastic variation and life-long accumulation of biomass is radial growth. Here, we use this term to describe the ability to grow in girth by the formation of wood, bast and cork. The more technical term for radial growth is secondary growth, which distinguishes the process from primary growth taking place at the tips of stems and roots during plant elongation...
September 11, 2017: Current Biology: CB
Chao Zhang, Meng-Qi Ma, Tingting Chen, He Zhang, Deng-Feng Hu, Bai-Heng Wu, Jian Ji, Zhi-Kang Xu
Surface modification has been well recognized as a promising strategy to design and exploit diversified functional materials. However, conventional modification strategies usually suffer from complicated manufacture procedures and lack of universality. Herein, a facile, robust and versatile approach is proposed to achieve the surface functionalization using dopamine and acrylate monomers via a one-step polymerization and co-deposition process. The GPC, 1H NMR, LC-MS and UV-vis spectra results indicate that dopamine possesses the capability of triggering the polymerization of acrylate monomers into high molecluar weight products, and the inherent adhesive ability of PDA can assist the polymerized products to deposit on various substrates...
September 12, 2017: ACS Applied Materials & Interfaces
Vadapalli Chandrasekhar, Enrique Colacio, J M Herrera, W Wernsdorfer, Y Lan, E Suturina, I Kuprov, J Goura
Two new heterometallic Zn3Dy3 (Ln3+=Dy, Tb) complexes with a double triangular topology of the metal ions have been assembled from the polytopicMannich base ligand 6,6'-{(2-(dimethylamino) ethyl azanediyl)bis(methylene)}bis(2-methoxy-4-methylphenol) (H2L)with the aidof in situ generated carbonate ligand from atmospheric CO2 fixation. Theoretical calculations indicate axial ground states for the Ln3+ ions in these complexes with their local magnetic moments being almost coplanarand tangential to the Ln3+ atoms defining the equilateral triangle...
September 11, 2017: Chemistry: a European Journal
Joseph Jankovic
The therapeutic applications of botulinum toxin (BoNT) have grown manifold since its initial approval in 1989 by the US Food and Drug Administration (FDA) for the treatment of strabismus, blepharospasm, and other facial spasms. Although it is the most potent biologic toxin known to man, long-term studies have established its safety in the treatment of a variety of neurologic and non-neurologic disorders. This review focuses on some novel and uncommon uses of BoNT in the treatment of movement disorders, such as oromandibular dystonia, including bruxism, anterocollis, camptocormia, tremor, tics, tardive and levodopa-induced dyskinesia, and restless legs syndrome...
September 6, 2017: Toxicon: Official Journal of the International Society on Toxinology
Arezoo Islami, Giuseppe Longo
The human attempts to access, measure and organize physical phenomena have led to a manifold construction of mathematical and physical spaces. We will survey the evolution of geometries from Euclid to the Algebraic Geometry of the 20th century. The role of Persian/Arabic Algebra in this transition and its Western symbolic development is emphasized. In this relation, we will also discuss changes in the ontological attitudes toward mathematics and its applications. Historically, the encounter of geometric and algebraic perspectives enriched the mathematical practices and their foundations...
September 5, 2017: Progress in Biophysics and Molecular Biology
Tiantian Liu, Minxin Chen, Yu Song, Hongliang Li, Benzhuo Lu
We present a systematic procedure to improve the qualities of triangular molecular surface meshes and at the same time preserve the manifoldness. The procedure utilizes an algorithm to remove redundant points having three or four valences and another algorithm to smooth the mesh using a modified version of Laplacian method without causing intersecting triangles. This approach can be effectively applied to any manifold surface meshes with arbitrary complex geometry. In this paper, the tested meshes are biomolecular surface meshes exhibiting typically highly irregular geometry...
2017: PloS One
Yao Zhang, Shengjing Tang, Jie Guo
In this paper, a novel adaptive-gain fast super-twisting (AGFST) sliding mode attitude control synthesis is carried out for a reusable launch vehicle subject to actuator faults and unknown disturbances. According to the fast nonsingular terminal sliding mode surface (FNTSMS) and adaptive-gain fast super-twisting algorithm, an adaptive fault tolerant control law for the attitude stabilization is derived to protect against the actuator faults and unknown uncertainties. Firstly, a second-order nonlinear control-oriented model for the RLV is established by feedback linearization method...
September 4, 2017: ISA Transactions
Eric William Driscoll, Jonathan Ryan Hunt, Jahan M Dawlaty
Converting light into chemical energy often occurs through redox reactions that require transfer of several electrons and protons. Using light to control proton transfer has potential for driving otherwise unfavorable protonation reactions or producing transient pH changes. Photoacids and photobases are fundamental functional elements that could serve this purpose. Previously, we have reported the thermodynamic drive for proton removal in a series of quinoline photobases using Forster cycle analysis of the singlet states...
September 7, 2017: Journal of Physical Chemistry. A
Jinyu Tian, Taiping Zhang, Anyong Qin, Zhaowei Shang, Yuan Yan Tang
This work proposes a new clustering method for images called Distribution Preserving Indexing (DPI). It aims to find a lower-dimensional semantic space approximating the original image space in the sense of preserving the distribution of the data. In the theory, the intrinsic structure of the data clusters can be described by the distribution of the data effectively. Therefore, the cluster structure of the data in a lower-dimensional semantic space derived by DPI becomes clear. Unlike these distance based clustering methods which reveal the intrinsic Euclidean structure of data, our method attempts to discover the intrinsic cluster structure of the data space that actually is the union of some sub-manifolds...
September 4, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
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