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https://www.readbyqxmd.com/read/29164404/size-selectivity-in-antibiofilm-activity-of-3-diphenylphosphino-propanoic-acid-coated-gold-nanomaterials-against-gram-positive-staphylococcus-aureus-and-streptococcus-mutans
#1
Dania Ahmed, Ayaz Anwar, Anum Khalid Khan, Ayaz Ahmed, Muhammad Raza Shah, Naveed Ahmed Khan
Biofilm formation by pathogenic bacteria is one of the major threats in hospital related infections, hence inhibiting and eradicating biofilms has become a primary target for developing new anti-infection approaches. The present study was aimed to develop novel antibiofilm agents against two Gram-positive bacteria; Staphylococcus aureus (ATCC 43300) and Streptococcus mutans (ATCC 25175) using gold nanomaterials conjugated with 3-(diphenylphosphino)propionic acid (Au-LPa). Gold nanomaterials with different sizes as 2-3 nm small and 9-90 nm (50 nm average size) large were stabilized by LPa via different chemical synthetic strategies...
November 21, 2017: AMB Express
https://www.readbyqxmd.com/read/29164091/review-of-the-campaign-to-prevent-falls-in-construction
#2
REVIEW
Kevin O'Donnell
Roofing is one of the most dangerous activities in the construction industry according to the US Bureau of Labor Statistics. Although injuries are manifold in this industry element, the vast majority of them occur as a result of falls from elevation (1, 2). These events lead to physical injury, fatalities, and financial burdens to the individual injured, their families, the employer, and the construction market as a whole (3, 4). In order to reduce construction worker falls, Occupational Health and Safety Administration launched the nationwide Campaign to Prevent Falls in Construction on April 26, 2012 (5)...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29164003/the-endocannabinoid-system-in-pain-and-inflammation-its-relevance-to-rheumatic-disease
#3
REVIEW
Nicola Barrie, Nicholas Manolios
Pain is the most common manifestation of both acute and chronic inflammation that often challenges patients with rheumatic disease. Simply, we attribute this to local joint changes of pH in joints, the formation of radicals, enhanced joint pressure, or cytokine release acting on local nerves to produce pain. However, there is a more complex interplay of interactions between cytokines, mediators of inflammation, and ion channels that influence the final immune response and our perception of pain. Endocannabinoids, a group of less well-known endogenous bioactive lipids, have such manifold immunomodulatory effects able to influence both inflammation and pain...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29162977/perioperative-management-of-patients-with-diabetes
#4
REVIEW
Vivien Leung, Kristal Ragbir-Toolsie
Hyperglycemia has long been recognized to have detrimental effects on postoperative outcomes in patients undergoing surgery. The manifestations of uncontrolled diabetes are manifold and can include risk of hyperglycemic crises, postoperative infection, poor wound healing, and increased mortality. There is substantial literature supporting the role of diligent glucose control in the prevention of adverse surgical outcomes, but considerable debate remains as to the optimal glucose targets. Hence, most organizations advocate the avoidance of hypoglycemia while striving for adequate glucose control in the perioperative period...
2017: Health Services Insights
https://www.readbyqxmd.com/read/29160773/rationalizing-substituent-effects-in-1-azathioxanthone-photophysics
#5
Anne Kathrine R Junker, Thomas Just Sørensen
The influence of an electron donating substituent on the photophysical properties of 1-azathioxanthone dyes has been investigated using optical spectroscopy and theoretical models. The motivation behind the study is based on the fact that thioxanthones are efficient triplet sensitizers, and thus promising sensitizers for lanthanide centered emission. By adding an aza group to one of the phenyl ring systems, direct coordination to a lanthanide center becomes possible, which makes azathoixanthones great candidates as antenna chromophores in lanthanide(III) based dyes...
November 21, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/29160072/solvent-controlled-branching-of-localized-versus-delocalized-singlet-exciton-states-and-equilibration-with-charge-transfer-in-a-structurally-well-defined-tetracene-dimer
#6
Jasper D Cook, Thomas J Carey, Dylan H Arias, Justin C Johnson, Niels H Damrauer
A detailed photophysical picture is elaborated for a structurally well-defined and symmetrical bis-tetracene dimer in solution. The molecule was designed for interrogation of the initial photophysical steps (S1 → (1)TT) in intramolecular singlet fission (SF). (Triisopropylsilyl)acetylene substituents on the dimer TIPS-BT1 as well as a monomer model TIPS-Tc enable a comparison of photophysical properties, including transient absorption dynamics, as solvent polarity is varied. In nonpolar toluene solutions, TIPS-BT1 decays via radiative and nonradiative pathways to the ground state with no evidence for dynamics related to the initial stages of SF...
November 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29159814/ceres-an-ab-initio-code-dedicated-to-the-calculation-of-the-electronic-structure-and-magnetic-properties-of-lanthanide-complexes
#7
Simone Calvello, Matteo Piccardo, Shashank Vittal Rao, Alessandro Soncini
We have developed and implemented a new ab initio code, Ceres (Computational Emulator of Rare Earth Systems), completely written in C++11, which is dedicated to the efficient calculation of the electronic structure and magnetic properties of the crystal field states arising from the splitting of the ground state spin-orbit multiplet in lanthanide complexes. The new code gains efficiency via an optimized implementation of a direct configurational averaged Hartree-Fock (CAHF) algorithm for the determination of 4f quasi-atomic active orbitals common to all multi-electron spin manifolds contributing to the ground spin-orbit multiplet of the lanthanide ion...
November 20, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29155789/efficient-generation-and-editing-of-feeder-free-ipscs-from-human-pancreatic-cells-using-the-crispr-cas9-system
#8
Anjali Nandal, Barbara Mallon, Bhanu P Telugu
Embryonic and induced pluripotent stem cells can self-renew and differentiate into multiple cell types of the body. The pluripotent cells are thus coveted for research in regenerative medicine and are currently in clinical trials for eye diseases, diabetes, heart diseases, and other disorders. The potential to differentiate into specialized cell types coupled with the recent advances in genome editing technologies including the CRISPR/Cas system have provided additional opportunities for tailoring the genome of iPSC for varied applications including disease modeling, gene therapy, and biasing pathways of differentiation, to name a few...
November 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29154440/mapping-of-the-available-chemical-space-versus-the-chemical-universe-of-lead-like-compounds
#9
Arkadii Lin, Dragos Horvath, Valentina Afonina, Gilles Marcou, Reymond Jean-Louis, Alexandre Varnek
This is, to our knowledge, the to-date most comprehensive analysis based on Generative Topographic Mapping (GTM) of the fragment-like chemical space (40M molecules with no more than 17 heavy atoms, both from the theoretically enumerated GDB-17, and real-world PubChem/ChEMBL). The challenge was to prove that a robust map of fragment-like chemical space can actually be built, in spite of a limited (<105) maximal number of compounds ("frame set") usable for fitting the GTM manifold. An evolutionary map building strategy has been updated with a "coverage check" step, discarding manifolds failing to accommodate compounds outside the frame set...
November 20, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29154390/circadian-profiling-reveals-higher-histamine-plasma-levels-and-lower-diamine-oxidase-serum-activities-in-24-of-patients-with-suspected-histamine-intolerance-compared-to-food-allergy-and-controls
#10
Theresa C Pinzer, Esther Tietz, Elisabeth Waldmann, Monic Schink, Markus F Neurath, Yurdagül Zopf
BACKGROUND: Histamine intolerance is thought to trigger manifold clinical symptoms after ingesting histamine-rich food due to reduced activity of diamine oxidase (DAO). No study has hitherto systematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patients. The aim of the study was to investigate the presence of histamine intolerance, to therefore establish day profiles of histamine levels and DAO activities, and to compare the results between patients with suspected histamine intolerance, food allergy and healthy controls...
November 20, 2017: Allergy
https://www.readbyqxmd.com/read/29150344/biomechanical-mechanism-of-lateral-trunk-lean-gait-for-knee-osteoarthritis-patients
#11
Kazuki Tokuda, Masaya Anan, Makoto Takahashi, Tomonori Sawada, Kenji Tanimoto, Nobuhiro Kito, Koichi Shinkoda
The biomechanical mechanism of lateral trunk lean gait employed to reduce external knee adduction moment (KAM) for knee osteoarthritis (OA) patients is not well known. This mechanism may relate to the center of mass (COM) motion. Moreover, lateral trunk lean gait may affect motor control of the COM displacement. Uncontrolled manifold (UCM) analysis is an evaluation index used to understand motor control and variability of the motor task. Here we aimed to clarify the biomechanical mechanism to reduce KAM during lateral trunk lean gait and how motor variability controls the COM displacement...
November 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29148243/are-new-devices-required-to-reduce-contrast-load-in-the-cath-lab-or-is-behavioral-change-sufficient
#12
EDITORIAL
Toby Rogers, Lowell F Satler
A novel device that diverts a proportion of contrast injected by hand through the manifold can potentially reduce volume of contrast delivered to the patient by almost 50% to reduce risk of contrast-induced nephropathy. Another simple solution to reducing contrast volume is to limit the number of angiographic views and cine runs acquired. A conscious effort by the angiographer to limit the contrast volume to less than the eGFR should be considered.
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29147146/relationships-between-short-and-fast-brain-timescales
#13
Eva Déli, Arturo Tozzi, James F Peters
Brain electric activity exhibits two important features: oscillations with different timescales, characterized by diverse functional and psychological outcomes, and a temporal power law distribution. In order to further investigate the relationships between low- and high- frequency spikes in the brain, we used a variant of the Borsuk-Ulam theorem which states that, when we assess the nervous activity as embedded in a sphere equipped with a fractal dimension, we achieve two antipodal points with similar features (the slow and fast, scale-free oscillations)...
December 2017: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/29143986/effect-of-second-order-spin-orbit-coupling-on-the-interaction-between-spin-states-in-spin-crossover-systems
#14
Carmen Sousa, Alex Domingo, Coen de Graaf
The second-order spin-orbit coupling is evaluated in two transition metal complexes to establish the effect on the deactivation mechanism of the excited low-spin state in systems that undergo spin transitions under the influence of light. We compare the standard perturbational approach to calculate the second-order interaction with a variational strategy based on effective Hamiltonian theory and show that the former one can only be applied in some special cases and even then gives results that largely overestimate the interaction...
November 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29138887/-developments-in-dysphagia-diagnostics-presentation-of-an-interdisciplinary-concept
#15
REVIEW
C Pflug, T Flügel, J C Nienstedt
Demographic developments and medical progress will cause the already high prevalence of swallowing disorders to increase further in the future. With the same number of specialists and economic resources, it is necessary to improve the efficiency of dysphagia diagnostics and continue to offer patients a treatment concept tailored to their needs. Manifold and often co-existing causes of dysphagia require interdisciplinary cooperation in this area. Endoscopic swallowing diagnostics play a prominent role in dysphagia diagnostics and should always contain thorough endoscopy of the upper aerodigestive tract-the domain of the ENT specialist and phoniatrician...
November 14, 2017: HNO
https://www.readbyqxmd.com/read/29136107/contextual-fear-extinction-induces-hippocampal-metaplasticity-mediated-by-metabotropic-glutamate-receptor-5
#16
Branden J Stansley, Nicole M Fisher, Rocco G Gogliotti, Craig W Lindsley, P Jeffrey Conn, Colleen M Niswender
Dysregulated fear memory can lead to a broad spectrum of anxiety disorders. The brain systems underlying fear memory are manifold, with the hippocampus being prominently involved by housing fear-related spatial memories as engrams, which are created and stored through neural changes such as synaptic plasticity. Although metabotropic glutamate (mGlu) receptors contribute significantly to both fear behavior and hippocampal synaptic plasticity, the relationship between these two phenomena has not been fully elucidated...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29130377/negotiating-horizontality-in-medical-south-south-cooperation-the-cuban-mission-in-rio-de-janeiro-s-urban-peripheries
#17
Maria Lidola, Fabiano Tonaco Borges
For more than 50 years, Cuba has been one of the most important players in the field of international medical cooperation in the Global South. Between 2013 and 2016, Cuba maintained one of its largest cooperations with Brazil: nearly 11,400 Cuban physicians were sent to work within the framework of the Brazilian health programme 'More-Doctors-for-Brazil', which was implemented to improve Brazil's precarious public health sector. This paper inquires into the manifold challenges of horizontal connectivity in this medical South-South cooperation...
November 13, 2017: Global Public Health
https://www.readbyqxmd.com/read/29129548/bifurcation-of-a-delayed-gause-predator-prey-model-with-michaelis-menten-type-harvesting
#18
Wei Liu, Yaolin Jiang
In this paper, a Gause predator-prey model with gestation delay and Michaelis-Menten type harvesting of prey is proposed and analyzed by considering Holling type III functional response. We first consider the local stability of the interior equilibrium by investigating the corresponding characteristic equation. In succession, we derive some sufficient conditions on the occurrence of the stability switches of the positive steady state by taking the gestation delay as a bifurcation parameter. It is shown that the delay can induce instability and small amplitude oscillations of population densities via Hopf bifurcations...
November 9, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29128535/branched-peptides-integrate-into-self-assembled-nanostructures-and-enhance-biomechanics-of-peptidic-hydrogels
#19
Raffaele Pugliese, Federico Fontana, Amanda Marchini, Fabrizio Gelain
Self-assembling peptides (SAP) have drawn an increasing interest in the tissue engineering community. They display unquestionable biomimetic properties, tailorability and promising biocompatibility. However their use has been hampered by poor mechanical properties making them fragile soft scaffolds. To increase SAP hydrogel stiffness we introduced a novel strategy based on multiple ramifications of (LDLK)3, a well-known linear SAP, connected with one or multiple "lysine knots". Differently branched SAPs were tested by increasing the number of (LDLK)3-like branches and by adding the neuro-regenerative functional motif BMHP1 as a single branch...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29126480/photometric-flow-analysis-system-for-biomedical-investigations-of-iron-transferrin-speciation-in-human-serum
#20
Kamil Strzelak, Natalia Rybkowska, Agnieszka Wiśniewska, Robert Koncki
The Multicommutated Flow Analysis (MCFA) system for the estimation of clinical iron parameters: Serum Iron (SI), Unsaturated Iron Binding Capacity (UIBC) and Total Iron Binding Capacity (TIBC) has been proposed. The developed MCFA system based on simple photometric detection of iron with chromogenic agent (ferrozine) enables a speciation of transferrin (determination of free and Fe-bound protein) in human serum. The construction of manifold was adapted to the requirements of measurements under changing conditions...
December 1, 2017: Analytica Chimica Acta
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