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https://www.readbyqxmd.com/read/27913239/strategy-for-assessment-of-the-colloidal-and-biological-stability-of-h1n1-influenza-a-viruses
#1
Frank Hämmerling, Oliver Lorenz-Cristea, Pascal Baumann, Jürgen Hubbuch
Current influenza vaccines are mostly formulated as liquids which requires a continuous cold chain to maintain the stability of the antigen. For development of vaccines with an increased stability at ambient temperatures, manifold parameters and their influences on the colloidal stability and activity of the antigen have to be understood. This work presents a strategy to examine both, the colloidal stability and the remaining biological activity of H1N1 influenza viruses under various conditions after an incubation of 40 days...
November 29, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27911557/bifurcations-and-singularities-for-coupled-oscillators-with-inertia-and-frustration
#2
J Barré, D Métivier
We prove that any nonzero inertia, however small, is able to change the nature of the synchronization transition in Kuramoto-like models, either from continuous to discontinuous or from discontinuous to continuous. This result is obtained through an unstable manifold expansion in the spirit of Crawford, which features singularities in the vicinity of the bifurcation. Far from being unwanted artifacts, these singularities actually control the qualitative behavior of the system. Our numerical tests fully support this picture...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27908704/on-the-relationship-between-cell-cycle-analysis-with-ergodic-principles-and-age-structured-cell-population-models
#3
K Kuritz, D Stöhr, N Pollak, F Allgöwer
Cyclic processes, in particular the cell cycle, are of great importance in cell biology. Continued improvement in cell population analysis methods like fluorescence microscopy, flow cytometry, CyTOF or single-cell omics made mathematical methods based on ergodic principles a powerful tool in studying these processes. In this paper, we establish the relationship between cell cycle analysis with ergodic principles and age structured population models. To this end, we describe the progression of a single cell through the cell cycle by a stochastic differential equation on a one dimensional manifold in the high dimensional dataspace of cell cycle markers...
November 28, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27908125/a-h%C3%A3-ckel-source-sink-potential-theory-of-pauli-spin-blockade-in-molecular-electronic-devices
#4
Barry T Pickup, Patrick W Fowler, Irene Sciriha
This paper shows how to include Pauli (exclusion principle) effects within a treatment of ballistic molecular conduction that uses the tight-binding Hückel Hamiltonian and the source-sink-potential (SSP) method. We take into account the many-electron ground-state of the molecule and show that we can discuss ballistic conduction for a specific molecular device in terms of four structural polynomials. In the standard one-electron picture, these are characteristic polynomials of vertex-deleted graphs, with spectral representations in terms of molecular-orbital eigenvectors and eigenvalues...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27908108/dual-hydrogen-bonding-motifs-in-complexes-formed-between-tropolone-and-formic-acid
#5
Deacon J Nemchick, Michael K Cohen, Patrick H Vaccaro
The near-ultraviolet π(*)←π absorption system of weakly bound complexes formed between tropolone (TrOH) and formic acid (FA) under cryogenic free-jet expansion conditions has been interrogated by exploiting a variety of fluorescence-based laser-spectroscopic probes, with synergistic quantum-chemical calculations built upon diverse model chemistries being enlisted to unravel the structural and dynamical properties of the pertinent ground [X̃(1)A(')] and excited [Ã(1)A(')π(*)π] electronic states. For binary TrOH ⋅ FA adducts, the presence of dual hydrogen-bond linkages gives rise to three low-lying isomers designated (in relative energy order) as INT, EXT1, and EXT2 depending on whether docking of the FA ligand to the TrOH substrate takes place internal or external to the five-membered reaction cleft of tropolone...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27906324/energy-level-systems-and-transitions-of-ho-luag-laser-resonantly-pumped-by-a-narrow-line-width-tm-fiber-laser
#6
Hao Chen, Ting Zhao, Hao Yang, Le Zhang, Tianyuan Zhou, Dingyuan Tang, Chingping Wong, Yung-Fu Chen, Deyuan Shen
We presented a Ho:LuAG ceramic laser in-band pumped by a narrow emission line-width Tm fiber laser at 1907 nm. All of potential transitions between 5I7 and 5I8 manifold were discussed to form the Ho's in-band-pump energy level systems, which were not described in details earlier. For the emission band centered at ~2095 nm, both laser absorption and emission transition separately consisted of two groups were first analyzed and observed. Using output couplers (OCs) with different transmittances (T = 6, 10 and 20%), the similar ~0...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27898431/improving-outcome-of-trauma-patients-by-implementing-patient-blood-management
#7
Christoph Füllenbach, Kai Zacharowski, Patrick Meybohm
PURPOSE OF REVIEW: Patient blood management aims to improve patient outcome and safety by reducing the number of unnecessary red blood cell transfusions and vitalizing patient-specific anemia reserves. While this is increasingly recognized as best clinical practice in elective surgery, the implementation in the setting of trauma is restrained because of typically nonelective (emergency) surgery and, in specific circumstances, allogeneic blood transfusions as life-saving therapy. RECENT FINDINGS: Viscoelastic diagnostics allow a precise identification of trauma-induced coagulopathy...
November 24, 2016: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27895652/rapid-evolution-of-manifold-crispr-systems-for-plant-genome-editing
#8
REVIEW
Levi Lowder, Aimee Malzahn, Yiping Qi
Advanced CRISPR-Cas9 based technologies first validated in mammalian cell systems are quickly being adapted for use in plants. These new technologies increase CRISPR-Cas9's utility and effectiveness by diversifying cellular capabilities through expression construct system evolution and enzyme orthogonality, as well as enhanced efficiency through delivery and expression mechanisms. Here, we review the current state of advanced CRISPR-Cas9 and Cpf1 capabilities in plants and cover the rapid evolution of these tools from first generation inducers of double strand breaks for basic genetic manipulations to second and third generation multiplexed systems with myriad functionalities, capabilities, and specialized applications...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27894124/extensive-degeneracy-coulomb-phase-and-magnetic-monopoles-in-artificial-square-ice
#9
Yann Perrin, Benjamin Canals, Nicolas Rougemaille
Artificial spin-ice systems are lithographically patterned arrangements of interacting magnetic nanostructures that were introduced as way of investigating the effects of geometric frustration in a controlled manner. This approach has enabled unconventional states of matter to be visualized directly in real space, and has triggered research at the frontier between nanomagnetism, statistical thermodynamics and condensed matter physics. Despite efforts to create an artificial realization of the square-ice model-a two-dimensional geometrically frustrated spin-ice system defined on a square lattice-no simple geometry based on arrays of nanomagnets has successfully captured the macroscopically degenerate ground-state manifold of the model...
November 28, 2016: Nature
https://www.readbyqxmd.com/read/27893390/unsupervised-multi-class-co-segmentation-via-joint-cut-over-l1-manifold-hyper-graph-of-discriminative-image-regions
#10
Jizhou Ma, Shuai Li, Hong Qin, Aimin Hao
This paper systematically advocates a robust and efficient unsupervised multi-class co-segmentation approach by leveraging underlying subspace manifold propagation to exploit the cross-image coherency. It can combat certain image cosegmentation difficulties due to viewpoint change, partial occlusion, complex background, transient illumination, and cluttering texture patterns. Our key idea is to construct a powerful hyper-graph joint-cut framework, which incorporates mid-level image regions based intra-image feature representation and L1- manifold graph based inter-image coherency exploration...
November 22, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27885517/octupolar-order-in-three-dimensions
#11
Giuseppe Gaeta, Epifanio G Virga
Octupolar order in three space dimensions is described by a real-valued, fully symmetric and traceless, third-rank tensor A. The real generalized eigenvalues of A are also the critical values of a real-valued potential [Formula: see text] defined on the unit sphere [Formula: see text] by A. Generalized eigenvalues of A and critical points of [Formula: see text] are equivalent means to describe octupolar order in a molecular assembly according to Buckingham's formula for the probability density distribution...
November 2016: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/27884392/robust-stabilization-of-underactuated-nonlinear-systems-a-fast-terminal-sliding-mode-approach
#12
Qudrat Khan, Rini Akmeliawati, Aamer Iqbal Bhatti, Mahmood Ashraf Khan
This paper presents a fast terminal sliding mode based control design strategy for a class of uncertain underactuated nonlinear systems. Strategically, this development encompasses those electro-mechanical underactuated systems which can be transformed into the so-called regular form. The novelty of the proposed technique lies in the hierarchical development of a fast terminal sliding attractor design for the considered class. Having established sliding mode along the designed manifold, the close loop dynamics become finite time stable which, consequently, result in high precision...
November 22, 2016: ISA Transactions
https://www.readbyqxmd.com/read/27879108/detecting-phase-transitions-in-collective-behavior-using-manifold-s-curvature
#13
Kelum Gajamannage, Erik M Bollt
If a given behavior of a multi-agent system restricts the phase variable to an invariant manifold, then we define a phase transition as a change of physical characteristics such as speed, coordination, and structure. We define such a phase transition as splitting an underlying manifold into two sub-manifolds with distinct dimensionalities around the singularity where the phase transition physically exists. Here, we propose a method of detecting phase transitions and splitting the manifold into phase transitions free sub-manifolds...
April 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/27879014/highly-efficient-reusable-sponge-type-catalyst-carriers-based-on-short-electrospun-fibers
#14
Gaigai Duan, Melissa Koehn-Serrano, Andreas Greiner
This study reports on gold nanoparticles (AuNPs) immobilized in a sponge made of short electrospun fibers (Au-sponge), which show surprisingly high reaction rates at extremely low gold amount. Au-sponges are made by freeze-drying of dispersions of short electrospun fibers with preimmobilization of AuNPs. The resulting Au-sponges show very low densities around 7 mg cm(-3) corresponding to a pore volume of about 150 mL g(-1) , but low surface area and very low amount of AuNPs in the range of 0.29-3.56 wt%. In general, catalysts with immobilized AuNPs show much low reaction rates compared to systems with dispersed AuNPs...
November 23, 2016: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/27876872/experimental-investigation-into-the-oxidation-reactivity-and-nanostructure-of-particulate-matter-from-diesel-engine-fuelled-with-diesel-polyoxymethylene-dimethyl-ethers-blends
#15
Hao Yang, Xinghu Li, Yan Wang, Mingfei Mu, Xuehao Li, Guiyue Kou
This paper focuses on oxidation reactivity and nanostructural characteristics of particulate matter (PM) emitted from diesel engine fuelled with different volume proportions of diesel/polyoxymethylene dimethyl ethers (PODEn) blends (P0, P10 and P20). PM was collected using a metal filter from the exhaust manifold. The collected PM samples were characterized using thermogravimetric analysis (TGA), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Raman spectroscopy. The TGA results indicated that the PM produced by P20 had the highest moisture and volatility contents and the fastest oxidation rate of solid carbon followed by P10 and P0 derived PM...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27875186/visualizing-shape-deformations-with-variation-of-geometric-spectrum
#16
Jiaxi Hu, Hajar Hamidian, Zichun Zhong, Jing Hua
This paper presents a novel approach based on spectral geometry to quantify and visualize non-isometric deformations of 3D surfaces by mapping two manifolds. The proposed method can determine multi-scale, non-isometric deformations through the variation of Laplace-Beltrami spectrum of two shapes. Given two triangle meshes, the spectra can be varied from one to another with a scale function defined on each vertex. The variation is expressed as a linear interpolation of eigenvalues of the two shapes. In each iteration step, a quadratic programming problem is constructed, based on our derived spectrum variation theorem and smoothness energy constraint, to compute the spectrum variation...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27874865/direct-observation-of-subpicosecond-vibrational-dynamics-in-photoexcited-myoglobin
#17
C Ferrante, E Pontecorvo, G Cerullo, M H Vos, T Scopigno
Determining the initial pathway for ultrafast energy redistribution within biomolecules is a challenge, and haem proteins, for which energy can be deposited locally in the haem moiety using short light pulses, are suitable model systems to address this issue. However, data acquired using existing experimental techniques that fail to combine sufficient structural sensitivity with adequate time resolution have resulted in alternative hypotheses concerning the interplay between energy flow among highly excited vibrational levels and potential concomitant electronic processes...
December 2016: Nature Chemistry
https://www.readbyqxmd.com/read/27871310/transcriptome-analysis-reveals-manifold-mechanisms-of-cyst-development-in-adpkd
#18
Rita M C de Almeida, Sherry G Clendenon, William G Richards, Michael Boedigheimer, Michael Damore, Sandro Rossetti, Peter C Harris, Britney-Shea Herbert, Wei Min Xu, Angela Wandinger-Ness, Heather H Ward, James A Glazier, Robert L Bacallao
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) causes progressive loss of renal function in adults as a consequence of the accumulation of cysts. ADPKD is the most common genetic cause of end-stage renal disease. Mutations in polycystin-1 occur in 87% of cases of ADPKD and mutations in polycystin-2 are found in 12% of ADPKD patients. The complexity of ADPKD has hampered efforts to identify the mechanisms underlying its pathogenesis. No current FDA (Federal Drug Administration)-approved therapies ameliorate ADPKD progression...
November 21, 2016: Human Genomics
https://www.readbyqxmd.com/read/27867350/berlyne-revisited-evidence-for-the-multifaceted-nature-of-hedonic-tone-in-the-appreciation-of-paintings-and-music
#19
Manuela M Marin, Allegra Lampatz, Michaela Wandl, Helmut Leder
In his seminal book on esthetics, Berlyne (1971) posited an inverted-U relationship between complexity and hedonic tone in arts appreciation, however, converging evidence for his theory is still missing. The disregard of the multidimensionality of complexity may explain some of the divergent results. Here, we argue that definitions of hedonic tone are manifold and systematically examined whether the nature of the relationship between complexity and hedonic tone is determined by the specific measure of hedonic tone...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27866261/anticipatory-postural-adjustments-and-anticipatory-synergy-adjustments-preparing-to-a-postural-perturbation-with-predictable-and-unpredictable-direction
#20
Daniele Piscitelli, Ali Falaki, Stanislaw Solnik, Mark L Latash
We explored two aspects of feed-forward postural control, anticipatory postural adjustments (APAs) and anticipatory synergy adjustments (ASAs) seen prior to self-triggered unloading with known and unknown direction of the perturbation. In particular, we tested two main hypotheses predicting contrasting changes in APAs and ASAs. The first hypothesis predicted no major changes in ASAs. The second hypothesis predicted delayed APAs with predominance of co-contraction patterns when perturbation direction was unknown...
November 19, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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