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https://www.readbyqxmd.com/read/28104650/genome-sequences-of-diverse-human-cytomegalovirus-strains-with-utility-in-drug-screening-and-vaccine-evaluation
#1
Kathleen Corcoran, Carly J Sherrod, Ellen F Perkowski, Jordan Texier, Fengsheng Li, I-Ming Wang, Michael McVoy, Tong-Ming Fu, Dirk P Dittmer
Cytomegalovirus displays genetic heterogeneity, which has implications for antiviral and vaccine development. Many studies have focused on laboratory isolates that have been extensively adapted for growth on fibroblasts. Here, we report whole-genome sequences for 10 human cytomegalovirus (HCMV) strains that readily grow on ARPE-19 human retinal pigment epithelial cells.
January 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28103684/activation-pathway-of-a-nucleoside-analog-inhibiting-respiratory-syncytial-virus-polymerase
#2
Paul C Jordan, Sarah K Stevens, Yuen Tam, Ryan P Pemberton, Shuvam Chaudhuri, Antitsa D Stoycheva, Natalia Dyatkina, Guangyi Wang, Julian A Symons, Jerome Deval, Leo Beigelman
Human respiratory syncytial virus (RSV) is a negative-sense RNA virus and a significant cause of respiratory infection in infants and the elderly. No effective vaccines or antiviral therapies are available for the treatment of RSV. ALS-8176 is a first-in-class nucleoside prodrug inhibitor of RSV replication currently under clinical evaluation. ALS-8112, the parent molecule of ALS-8176, undergoes intracellular phosphorylation, yielding the active 5'-triphosphate metabolite. The host kinases responsible for this conversion are not known...
January 20, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28100498/the-predominant-cd4-th1-cytokine-elicited-to-chlamydia-trachomatis-infection-in-women-is-tumor-necrosis-factor-alpha-not-interferon-gamma
#3
Stephen J Jordan, Kanupriya Gupta, Brian M O Ogendi, Rakesh K Bakshi, Richa Kapil, Christen G Press, Steffanie Sabbaj, Jeannette Y Lee, William M Geisler
Chlamydia trachomatis infection is the most prevalent bacterial sexually transmitted infection and can cause significant reproductive morbidity in women. There is insufficient knowledge of C. trachomatis-specific immune responses in humans, which could be important in guiding vaccine development efforts. In contrast, murine models have clearly demonstrated the essential role of Type 1 T helper cells (Th1), especially interferon-gamma (IFN-γ) producing CD4(+) T-cells, in protective immunity to chlamydia. To determine the frequency and magnitude of Th1 cytokine responses elicited to C...
January 18, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28054443/risk-mitigation-of-emerging-zoonoses-hendra-virus-and-non-vaccinating-horse-owners
#4
J Manyweathers, H Field, D Jordan, N Longnecker, K Agho, C Smith, M Taylor
Hendra virus was identified in horses and humans in 1994, in Queensland, Australia. Flying foxes are the natural host. Horses are thought to acquire infection by direct or indirect contact with infected flying fox urine. Humans are infected from close contact with infected horses. To reduce risk of infection in horses and humans, Australian horse owners are encouraged to vaccinate horses against the virus and adopt property risk mitigation practices that focus on reducing flying fox horse contact and contamination of horses' environment with flying fox bodily fluids...
January 4, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/27931293/pulmonologist-perspectives-regarding-diagnosis-and-management-of-primary-immunodeficiency-diseases
#5
Jordan S Orange, Javeed Akhter, Filiz O Seeborg, Marcia Boyle, Christopher Scalchunes, Vivian Hernandez-Trujillo
BACKGROUND: The time from symptom onset to diagnosis for patients with primary immunodeficiency diseases (PIDD) is an average of 12 years, but prompt diagnosis and treatment can promote best outcomes. OBJECTIVE: Because the manifestations of PIDD are often sinopulmonary in nature, patients with undiagnosed PIDD are frequently referred to pulmonologists. This study sought to identify opportunities among these specialists to improve diagnosis and clinical management of patients with PIDD...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27836775/insights-from-molecular-structure-predictions-of-the-infectious-bronchitis-virus-s1-spike-glycoprotein
#6
Christina Lora M Leyson, Brian J Jordan, Mark W Jackwood
Infectious bronchitis virus is an important respiratory pathogen in chickens. The IBV S1 spike is a viral structural protein that is responsible for attachment to host receptors and is a major target for neutralizing antibodies. To date, there is no experimentally determined structure for the IBV S1 spike. In this study, we sought to find a predicted tertiary structure for IBV S1 using I-TASSER, which is an automated homology modeling platform. We found that the predicted structures obtained were robust and consistent with experimental data...
December 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27748651/acute-respiratory-disease-in-us-army-trainees-3-years-after-reintroduction-of-adenovirus-vaccine-1
#7
Nakia S Clemmons, Zachary D McCormic, Joel C Gaydos, Anthony W Hawksworth, Nikki N Jordan
The 1999 cessation of vaccination against adenovirus types 4 and 7 among US Army trainees resulted in reemergence of acute respiratory disease (ARD) outbreaks. The 2011 implementation of a replacement vaccine led to dramatic and sustained decreases in ARD cases, supporting continuation of vaccination in this population at high risk for ARD.
January 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27738031/complete-genome-sequence-of-the-goatpox-virus-strain-gorgan-obtained-directly-from-a-commercial-live-attenuated-vaccine
#8
Elisabeth Mathijs, Frank Vandenbussche, Andy Haegeman, Ahmad Al-Majali, Kris De Clercq, Steven Van Borm
This is a report of the complete genome sequence of the goatpox virus strain Gorgan, which was obtained directly from a commercial live attenuated vaccine (Caprivac, Jordan Bio-Industries Centre).
October 13, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27714744/molecular-epidemiology-and-evolution-of-a-h1n1-pdm09-and-h3n2-viruses-in-jordan-2011-2013
#9
R El Shesheny, N B Halasa, J V Williams, A A Shehabi, S Faouri, G Kayali, N Khuri-Bulos
Understanding the genetic evolution of A(H1N1)pdm09 and H3N2 viruses can help better select strains to be included in the annual influenza vaccine. There is little information on their evolution in Jordan so this study investigated the genetic and antigenic variability of A(H1N1)pdm09 and H3N2 viruses in Jordan by performing phylogenetic and genetic analyses of the HA and NA genes of A(H1N1)pdm09 and H3N2 viruses between 2011 and 2013. The full HA and NA genes of 16 H1N1-positive samples obtained in our study and 21 published HA sequences and 20 published NA sequences from Jordanian viruses that were available on online gene databases were analysed...
October 2, 2016: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/27702895/sustained-antigen-availability-during-germinal-center-initiation-enhances-antibody-responses-to-vaccination
#10
Hok Hei Tam, Mariane B Melo, Myungsun Kang, Jeisa M Pelet, Vera M Ruda, Maria H Foley, Joyce K Hu, Sudha Kumari, Jordan Crampton, Alexis D Baldeon, Rogier W Sanders, John P Moore, Shane Crotty, Robert Langer, Daniel G Anderson, Arup K Chakraborty, Darrell J Irvine
Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the immune system responds optimally to antigen kinetics most similar to replicating infections, rather than a bolus dose. Using HIV antigens, we found that administering a given total dose of antigen and adjuvant over 1-2 wk through repeated injections or osmotic pumps enhanced humoral responses, with exponentially increasing (exp-inc) dosing profiles eliciting >10-fold increases in antibody production relative to bolus vaccination post prime...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27647928/maternally-derived-anti-fibroblast-growth-factor-23-antibody-as-new-tool-to-reduce-phosphorus-requirement-of-chicks
#11
Zhouzheng Ren, Daniel E Bütz, Jordan M Sand, Mark E Cook
Novel means to reduce phosphate input into poultry feeds and increase its retention would preserve world phosphate reserves and reduce environmental impact of poultry production. Here we show that a maternally derived antibody to a fibroblast growth factor-23 (FGF-23) peptide (GMNPPPYS) alleviated phosphorus deficiency in chicks fed low non-phytate phosphorus (nPP) diets. White Leghorn laying hens were vaccinated with either an adjuvant control or the synthetic FGF-23 peptide, and chicks with control or anti-FGF-23 maternal antibodies were fed a diet containing either 0...
September 19, 2016: Poultry Science
https://www.readbyqxmd.com/read/27643974/physicians-nurses-and-medical-assistants-perceptions-of-the-human-papillomavirus-vaccine-in-a-large-integrated-health-care-system
#12
Jordan Mills, Patrick Van Winkle, Macy Shen, Christina Hong, Sharon Hudson
CONTEXT: Vaccination against the human papillomavirus (HPV) decreases risks of cancer and genital warts and the need for gynecologic procedures, yet nationwide vaccination rates are low. Previous surveys exploring this phenomenon have not included input from nurses and medical assistants, who play integral roles in HPV vaccine delivery. OBJECTIVE: To understand perceptions of HPV vaccine delivery among physicians, nurses, and medical assistants in a large integrated health care system in Southern California...
2016: Permanente Journal
https://www.readbyqxmd.com/read/27636738/high-resolution-analysis-of-antibodies-to-post-translational-modifications-using-peptide-nanosensor-microarrays
#13
Jung-Rok Lee, D James Haddon, Nidhi Gupta, Jordan V Price, Grace M Credo, Vivian K Diep, Kyunglok Kim, Drew A Hall, Emily C Baechler, Michelle Petri, Madoo Varma, Paul J Utz, Shan X Wang
Autoantibodies are a hallmark of autoimmune diseases such as lupus and have the potential to be used as biomarkers for diverse diseases, including immunodeficiency, infectious disease, and cancer. More precise detection of antibodies to specific targets is needed to improve diagnosis of such diseases. Here, we report the development of reusable peptide microarrays, based on giant magnetoresistive (GMR) nanosensors optimized for sensitively detecting magnetic nanoparticle labels, for the detection of antibodies with a resolution of a single post-translationally modified amino acid...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27619927/polymorphisms-in-the-s1-spike-glycoprotein-of-arkansas-type-infectious-bronchitis-virus-ibv-show-differential-binding-to-host-tissues-and-altered-antigenicity
#14
Christina Leyson, Monique França, Mark Jackwood, Brian Jordan
Sequencing avian infectious bronchitis virus spike genes re-isolated from vaccinated chicks revealed that many sequence changes are found on the S1 spike gene. In the ArkDPI strain, Y43H and ∆344 are the two most common changes observed. This study aims to examine the roles of Y43H and ∆344 in selection in vivo. Using recombinant ArkDPI S1 proteins, we conducted binding assays on chicken tracheas and embryonic chorioallantoic membrane (CAM). Protein histochemistry showed that the Y43H change allows for enhanced binding to trachea, whereas the ArkDPI S1 spike with H43 alone was able to bind CAM...
November 2016: Virology
https://www.readbyqxmd.com/read/27575957/interventions-for-men-and-women-with-their-first-episode-of-genital-herpes
#15
REVIEW
Rachel Heslop, Helen Roberts, Deralie Flower, Vanessa Jordan
BACKGROUND: Genital herpes is incurable, and is caused by the herpes simplex virus (HSV). First-episode genital herpes is the first clinical presentation of herpes that a person experiences. Current treatment is based around viral suppression in order to decrease the length and severity of the episode. OBJECTIVES: To determine the effectiveness and safety of the different existing treatments for first-episode genital herpes on the duration of symptoms and time to recurrence...
August 30, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27567011/knowledge-awareness-and-practices-towards-seasonal-influenza-and-its-vaccine-implications-for-future-vaccination-campaigns-in-jordan
#16
Eman Y Abu-Rish, Eman R Elayeh, Lubabah A Mousa, Yasser K Butanji, Abla M Albsoul-Younes
BACKGROUND: Influenza is an underestimated contributor to morbidity and mortality. Population knowledge regarding influenza and its vaccination has a key role in enhancing vaccination coverage. OBJECTIVES: This study aimed to identify the gaps of knowledge among Jordanian population towards influenza and its vaccine, and to identify the major determinants of accepting seasonal influenza vaccine in adults and children in Jordan. METHODS: This was a cross-sectional study that enrolled 941 randomly selected adults in Amman, Jordan...
December 2016: Family Practice
https://www.readbyqxmd.com/read/27515826/assessment-of-pfs25-expressed-from-multiple-soluble-expression-platforms-for-use-as-transmission-blocking-vaccine-candidates
#17
Shwu-Maan Lee, Chia-Kuei Wu, Jordan Plieskatt, David H McAdams, Kazutoyo Miura, Chris Ockenhouse, C Richter King
BACKGROUND: Transmission-blocking vaccines (TBVs) have become a focus of strategies to control and eventually eliminate malaria as they target the entry of sexual stage into the Anopheles stephensi mosquito thereby preventing transmission, an essential component of the parasite life cycle. Such vaccines are envisioned as complements to vaccines that target human infection, such as RTS,S as well as drug treatment, and vector control strategies. A number of conserved proteins, including Pfs25, have been identified as promising TBV targets in research or early stage development...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27509083/influenza-vaccination-coverage-rates-knowledge-attitudes-and-beliefs-in-jordan-a-comprehensive-study
#18
Areej M Assaf, Eman A Hammad, Randa N Haddadin
Influenza vaccination is the most effective method in preventing influenza and its complications. This study's objectives were to investigate the vaccination coverage and frequency and to assess knowledge, attitudes, and practices toward influenza vaccination in Jordan during the year 2012 and the 5 years preceding it. Additionally, it aimed at identifying the barriers and motivations to receive the vaccine and the factors contributing to its uptake. In May 2012, a self-administered cross-sectional survey was distributed to 3,200 adults conveniently selected across Jordan to explore influenza vaccination status, knowledge, attitudes, and practices toward the influenza vaccine...
August 10, 2016: Viral Immunology
https://www.readbyqxmd.com/read/27497954/state-of-inequality-in-diphtheria-tetanus-pertussis-immunisation-coverage-in-low-income-and-middle-income-countries-a-multicountry-study-of-household-health-surveys
#19
Ahmad Reza Hosseinpoor, Nicole Bergen, Anne Schlotheuber, Marta Gacic-Dobo, Peter M Hansen, Kamel Senouci, Ties Boerma, Aluisio J D Barros
BACKGROUND: Immunisation programmes have made substantial contributions to lowering the burden of disease in children, but there is a growing need to ensure that programmes are equity-oriented. We aimed to provide a detailed update about the state of between-country inequality and within-country economic-related inequality in the delivery of three doses of the combined diphtheria, tetanus toxoid, and pertussis-containing vaccine (DTP3), with a special focus on inequalities in high-priority countries...
September 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27350507/using-healthmap-to-analyse-middle-east-respiratory-syndrome-mers-data
#20
Nassif Hossain, Mowafa Househ
In this paper, a web-based disease surveillance platform known as HealthMap is used to retrieve and analyze data pertaining to the Middle East Respiratory Syndrome (MERS) within the geographical confinements of the Arab World and North African countries. An account was opened with HealthMap to gain access to data related to MERS for the time-period 9 September 2015 to 7 March 2015. HealthMap accumulates and assesses outbreak data from a range of sources, this includes news media (Google News (Arabic)), validated official alerts (WHO) and expert-curated accounts (ProMED)...
2016: Studies in Health Technology and Informatics
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