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jordan, vaccines

Nakia S Clemmons, Zachary D McCormic, Joel C Gaydos, Anthony W Hawksworth, Nikki N Jordan
The 1999 cessation of vaccination against adenovirus types 4 and 7 among US Army trainees resulted in reemergence of acute respiratory disease (ARD) outbreaks. The 2011 implementation of a replacement vaccine led to dramatic and sustained decreases in ARD cases, supporting continuation of vaccination in this population at high risk for ARD.
January 15, 2017: Emerging Infectious Diseases
Elisabeth Mathijs, Frank Vandenbussche, Andy Haegeman, Ahmad Al-Majali, Kris De Clercq, Steven Van Borm
This is a report of the complete genome sequence of the goatpox virus strain Gorgan, which was obtained directly from a commercial live attenuated vaccine (Caprivac, Jordan Bio-Industries Centre).
October 13, 2016: Genome Announcements
R El Shesheny, N B Halasa, J V Williams, A A Shehabi, S Faouri, G Kayali, N Khuri-Bulos
Understanding the genetic evolution of A(H1N1)pdm09 and H3N2 viruses can help better select strains to be included in the annual influenza vaccine. There is little information on their evolution in Jordan so this study investigated the genetic and antigenic variability of A(H1N1)pdm09 and H3N2 viruses in Jordan by performing phylogenetic and genetic analyses of the HA and NA genes of A(H1N1)pdm09 and H3N2 viruses between 2011 and 2013. The full HA and NA genes of 16 H1N1-positive samples obtained in our study and 21 published HA sequences and 20 published NA sequences from Jordanian viruses that were available on online gene databases were analysed...
October 2, 2016: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Hok Hei Tam, Mariane B Melo, Myungsun Kang, Jeisa M Pelet, Vera M Ruda, Maria H Foley, Joyce K Hu, Sudha Kumari, Jordan Crampton, Alexis D Baldeon, Rogier W Sanders, John P Moore, Shane Crotty, Robert Langer, Daniel G Anderson, Arup K Chakraborty, Darrell J Irvine
Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the immune system responds optimally to antigen kinetics most similar to replicating infections, rather than a bolus dose. Using HIV antigens, we found that administering a given total dose of antigen and adjuvant over 1-2 wk through repeated injections or osmotic pumps enhanced humoral responses, with exponentially increasing (exp-inc) dosing profiles eliciting >10-fold increases in antibody production relative to bolus vaccination post prime...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
Zhouzheng Ren, Daniel E Bütz, Jordan M Sand, Mark E Cook
Novel means to reduce phosphate input into poultry feeds and increase its retention would preserve world phosphate reserves and reduce environmental impact of poultry production. Here we show that a maternally derived antibody to a fibroblast growth factor-23 (FGF-23) peptide (GMNPPPYS) alleviated phosphorus deficiency in chicks fed low non-phytate phosphorus (nPP) diets. White Leghorn laying hens were vaccinated with either an adjuvant control or the synthetic FGF-23 peptide, and chicks with control or anti-FGF-23 maternal antibodies were fed a diet containing either 0...
September 19, 2016: Poultry Science
Jordan Mills, Patrick Van Winkle, Macy Shen, Christina Hong, Sharon Hudson
CONTEXT: Vaccination against the human papillomavirus (HPV) decreases risks of cancer and genital warts and the need for gynecologic procedures, yet nationwide vaccination rates are low. Previous surveys exploring this phenomenon have not included inputfrom nurses and medical assistants, who play integral roles in HPV vaccine delivery. OBJECTIVE: To understand perceptions of HPV vaccine delivery among physicians, nurses, and medical assistants in a large integrated health care system in Southern California...
September 14, 2016: Permanente Journal
Jung-Rok Lee, D James Haddon, Nidhi Gupta, Jordan V Price, Grace M Credo, Vivian K Diep, Kyunglok Kim, Drew A Hall, Emily C Baechler, Michelle Petri, Madoo Varma, Paul J Utz, Shan X Wang
Autoantibodies are a hallmark of autoimmune diseases such as lupus and have the potential to be used as biomarkers for diverse diseases, including immunodeficiency, infectious disease, and cancer. More precise detection of antibodies to specific targets is needed to improve diagnosis of such diseases. Here, we report the development of reusable peptide microarrays, based on giant magnetoresistive (GMR) nanosensors optimized for sensitively detecting magnetic nanoparticle labels, for the detection of antibodies with a resolution of a single post-translationally modified amino acid...
September 16, 2016: ACS Nano
Christina Leyson, Monique França, Mark Jackwood, Brian Jordan
Sequencing avian infectious bronchitis virus spike genes re-isolated from vaccinated chicks revealed that many sequence changes are found on the S1 spike gene. In the ArkDPI strain, Y43H and ∆344 are the two most common changes observed. This study aims to examine the roles of Y43H and ∆344 in selection in vivo. Using recombinant ArkDPI S1 proteins, we conducted binding assays on chicken tracheas and embryonic chorioallantoic membrane (CAM). Protein histochemistry showed that the Y43H change allows for enhanced binding to trachea, whereas the ArkDPI S1 spike with H43 alone was able to bind CAM...
November 2016: Virology
Rachel Heslop, Helen Roberts, Deralie Flower, Vanessa Jordan
BACKGROUND: Genital herpes is incurable, and is caused by the herpes simplex virus (HSV). First-episode genital herpes is the first clinical presentation of herpes that a person experiences. Current treatment is based around viral suppression in order to decrease the length and severity of the episode. OBJECTIVES: To determine the effectiveness and safety of the different existing treatments for first-episode genital herpes on the duration of symptoms and time to recurrence...
2016: Cochrane Database of Systematic Reviews
Eman Y Abu-Rish, Eman R Elayeh, Lubabah A Mousa, Yasser K Butanji, Abla M Albsoul-Younes
BACKGROUND: Influenza is an underestimated contributor to morbidity and mortality. Population knowledge regarding influenza and its vaccination has a key role in enhancing vaccination coverage. OBJECTIVES: This study aimed to identify the gaps of knowledge among Jordanian population towards influenza and its vaccine, and to identify the major determinants of accepting seasonal influenza vaccine in adults and children in Jordan. METHODS: This was a cross-sectional study that enrolled 941 randomly selected adults in Amman, Jordan...
August 27, 2016: Family Practice
Shwu-Maan Lee, Chia-Kuei Wu, Jordan Plieskatt, David H McAdams, Kazutoyo Miura, Chris Ockenhouse, C Richter King
BACKGROUND: Transmission-blocking vaccines (TBVs) have become a focus of strategies to control and eventually eliminate malaria as they target the entry of sexual stage into the Anopheles stephensi mosquito thereby preventing transmission, an essential component of the parasite life cycle. Such vaccines are envisioned as complements to vaccines that target human infection, such as RTS,S as well as drug treatment, and vector control strategies. A number of conserved proteins, including Pfs25, have been identified as promising TBV targets in research or early stage development...
2016: Malaria Journal
Areej M Assaf, Eman A Hammad, Randa N Haddadin
Influenza vaccination is the most effective method in preventing influenza and its complications. This study's objectives were to investigate the vaccination coverage and frequency and to assess knowledge, attitudes, and practices toward influenza vaccination in Jordan during the year 2012 and the 5 years preceding it. Additionally, it aimed at identifying the barriers and motivations to receive the vaccine and the factors contributing to its uptake. In May 2012, a self-administered cross-sectional survey was distributed to 3,200 adults conveniently selected across Jordan to explore influenza vaccination status, knowledge, attitudes, and practices toward the influenza vaccine...
August 10, 2016: Viral Immunology
Ahmad Reza Hosseinpoor, Nicole Bergen, Anne Schlotheuber, Marta Gacic-Dobo, Peter M Hansen, Kamel Senouci, Ties Boerma, Aluisio J D Barros
BACKGROUND: Immunisation programmes have made substantial contributions to lowering the burden of disease in children, but there is a growing need to ensure that programmes are equity-oriented. We aimed to provide a detailed update about the state of between-country inequality and within-country economic-related inequality in the delivery of three doses of the combined diphtheria, tetanus toxoid, and pertussis-containing vaccine (DTP3), with a special focus on inequalities in high-priority countries...
September 2016: Lancet Global Health
Nassif Hossain, Mowafa Househ
In this paper, a web-based disease surveillance platform known as HealthMap is used to retrieve and analyze data pertaining to the Middle East Respiratory Syndrome (MERS) within the geographical confinements of the Arab World and North African countries. An account was opened with HealthMap to gain access to data related to MERS for the time-period 9 September 2015 to 7 March 2015. HealthMap accumulates and assesses outbreak data from a range of sources, this includes news media (Google News (Arabic)), validated official alerts (WHO) and expert-curated accounts (ProMED)...
2016: Studies in Health Technology and Informatics
Saad Gharaibeh, Shadi Amareen
Avian influenza subtype H9N2 is endemic in many countries in the Middle East. The reported prevalence of infection was variable between countries and ranged from 28.7% in Tunisia to 71% in Jordan. Several commercial killed whole-virus vaccine products are used as monovalent or bivalent mixed with Newcastle disease virus. Recently, we have noticed that many of the vaccinated broiler flocks did not show a production advantage over nonvaccinated flocks in the field. A new avian influenza field virus (H9N2) was isolated from these vaccinated and infected broiler flocks in 2013...
May 2016: Avian Diseases
Karl W Boehme, Mine' Ikizler, Jason A Iskarpatyoti, J Denise Wetzel, Jordan Willis, James E Crowe, Celia C LaBranche, David C Montefiori, Gregory J Wilson, Terence S Dermody
The gp41 membrane-proximal external region (MPER) is a target for broadly neutralizing antibody responses against human immunodeficiency virus type 1 (HIV-1). However, replication-defective virus vaccines currently under evaluation in clinical trials do not efficiently elicit MPER-specific antibodies. Structural modeling suggests that the MPER forms an α-helical coiled coil that is required for function and immunogenicity. To maintain the native MPER conformation, we used reverse genetics to engineer replication-competent reovirus vectors that displayed MPER sequences in the α-helical coiled-coil tail domain of viral attachment protein σ1...
May 2016: MSphere
Ruta Arays, Sahil Goyal, Kim M Jordan
Common variable immunodeficiency (CVID) is readily considered in patients presenting with recurrent sino-pulmonary infections, however this disease has a broad range of clinical manifestations and diagnosis can be delayed by several years. We present the case of a 44-year-old postpartum female who presented with nausea, vomiting and abdominal distension. Four years prior, she was hospitalized for treatment of immune thrombocytopenia (ITP) with splenectomy and rituximab followed by two episodes of bacterial meningitis despite immunizations...
August 2016: Postgraduate Medicine
Delphine Knittel, Adeline Gadzinski, Stéphane Hua, Jordan Denizeau, Alexandra Savatier, Philippe de la Rochère, Jean-Claude Boulain, Sebastian Amigorena, Eliane Piaggio, Christine Sedlik, Michel Léonetti
Heparan sulfates (HS) are carbohydrate moieties of HS proteoglycans (HSPGs). They often represent alternative attachment points for proteins or microorganisms targeting receptors. HSPGs, which are ubiquitously expressed, thereby participate in numerous biological processes. We previously showed that MHC class II-restricted antigen presentation is increased when antigens are coupled to HS ligands, suggesting that HSPGs might contribute to adaptive immune responses. Here, we examined if HSPG targeting influences other aspects of immune responses...
June 8, 2016: Vaccine
Jordan S Orange, Filiz O Seeborg, Marcia Boyle, Christopher Scalchunes, Vivian Hernandez-Trujillo
Primary immunodeficiency diseases (PIDs) include over 250 diverse disorders. The current study assessed management of PID by family practice physicians. The American Academy of Allergy, Asthma, and Immunology Primary Immunodeficiency Committee and the Immune Deficiency Foundation conducted an incentivized mail survey of family practice physician members of the American Medical Association and the American Osteopathic Association in direct patient care. Responses were compared with subspecialist immunologist responses from a similar survey...
2016: Frontiers in Medicine
Kimberly D Pringle, Maritza Patzi, Jacqueline E Tate, Volga Iniguez Rojas, Manish Patel, Lucia Inchauste Jordan, Raul Montesano, Adolfo Zarate, Lucia De Oliveira, Umesh Parashar
BACKGROUND: In Bolivia, monovalent rotavirus vaccine was introduced in 2008 and a previous evaluation reported a vaccine effectiveness (VE) of 77% with 2 doses of vaccine in children aged <3 years. This evaluation sought to determine if rotavirus vaccine provided protection through the second year of life against circulating genotypes. METHODS: A case-control study was performed in 5 hospitals from April 2013 to March 2014. Among enrolled participants who met study criteria and had rotavirus stool testing performed and vaccine status confirmed, we calculated VE using a logistic regression model...
May 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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