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https://www.readbyqxmd.com/read/28729620/self-management-behaviour-and-support-among-primary-care-copd-patients-cross-sectional-analysis-of-data-from-the-birmingham-chronic-obstructive-pulmonary-disease-cohort
#1
Ainee Khan, Andrew P Dickens, Peymane Adab, Rachel E Jordan
Self-management support for chronic obstructive pulmonary disease (COPD) patients is recommended by UK national guidelines, but extent of implementation is unknown. We aimed to describe self-management behaviour and support among COPD patients and explore behaviour associated with having a self-management plan. We undertook cross-sectional analysis of self-reported data from diagnosed COPD patients in the Birmingham COPD Cohort study. Questionnaire items relevant to self-management behaviour, knowledge of COPD, receipt of self-management plans and advice from healthcare professionals were examined...
July 20, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28713676/immunotherapy-for-malignant-pleural-mesothelioma-current-status-and-future-directions
#2
REVIEW
Jordan Dozier, Hua Zheng, Prasad S Adusumilli
Malignant pleural mesothelioma (MPM) has been marked historically by poor prognosis. Current standard of care for this deadly disease results in sub-optimal improvements in overall survival (OS), which has prompted researchers to explore innovative treatment alternatives. Immunotherapy is an emerging therapeutic modality that harnesses the power of the human immune system. In this review, we summarize the different methods of immunotherapy for malignant pleural mesothelioma. Using ClinicalTrials.gov we searched the terms "immunotherapy" and "immune therapy" combined with "pleural mesothelioma"...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28686416/decorating-self-assembled-peptide-cages-with-proteins
#3
James F Ross, Angela Bridges, Jordan M Fletcher, Deborah Shoemark, Dominic Alibhai, Harriet E V Bray, Joseph L Beesley, William M Dawson, Lorna R Hodgson, Judith Mantell, Paul Verkade, Colin M Edge, Richard B Sessions, David Tew, Derek N Woolfson
An ability to organize and encapsulate multiple active proteins into defined objects and spaces at the nanoscale has potential applications in biotechnology, nanotechnology, and synthetic biology. Previously, we have described the design, assembly, and characterization of peptide-based self-assembled cages (SAGEs). These ≈100 nm particles comprise thousands of copies of de novo designed peptide-based hubs that array into a hexagonal network and close to give caged structures. Here, we show that, when fused to the designed peptides, various natural proteins can be co-assembled into SAGE particles...
July 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/28659436/broad-spectrum-antiviral-gs-5734-inhibits-both-epidemic-and-zoonotic-coronaviruses
#4
Timothy P Sheahan, Amy C Sims, Rachel L Graham, Vineet D Menachery, Lisa E Gralinski, James B Case, Sarah R Leist, Krzysztof Pyrc, Joy Y Feng, Iva Trantcheva, Roy Bannister, Yeojin Park, Darius Babusis, Michael O Clarke, Richard L Mackman, Jamie E Spahn, Christopher A Palmiotti, Dustin Siegel, Adrian S Ray, Tomas Cihlar, Robert Jordan, Mark R Denison, Ralph S Baric
Emerging viral infections are difficult to control because heterogeneous members periodically cycle in and out of humans and zoonotic hosts, complicating the development of specific antiviral therapies and vaccines. Coronaviruses (CoVs) have a proclivity to spread rapidly into new host species causing severe disease. Severe acute respiratory syndrome CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV) successively emerged, causing severe epidemic respiratory disease in immunologically naïve human populations throughout the globe...
June 28, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28588580/specific-antibody-deficiency-controversies-in-diagnosis-and-management
#5
REVIEW
Elena Perez, Francisco A Bonilla, Jordan S Orange, Mark Ballow
Specific antibody deficiency (SAD) is a primary immunodeficiency disease characterized by normal immunoglobulins (Igs), IgA, IgM, total IgG, and IgG subclass levels, but with recurrent infection and diminished antibody responses to polysaccharide antigens following vaccination. There is a lack of consensus regarding the diagnosis and treatment of SAD, and its clinical significance is not well understood. Here, we discuss current evidence and challenges regarding the diagnosis and treatment of SAD. SAD is normally diagnosed by determining protective titers in response to the 23-valent pneumococcal polysaccharide vaccine...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28545100/intranasal-delivery-of-a-bivalent-norovirus-vaccine-formulated-in-an-in-situ-gelling-dry-powder
#6
Jordan P Ball, Michael J Springer, Yawei Ni, Isaac Finger-Baker, Juan Martinez, Jessica Hahn, John F Suber, Ashley V DiMarco, James D Talton, Ronald R Cobb
The global health community is beginning to understand the burden of norovirus-associated disease, which has a significant impact in both developed and developing countries. Norovirus virus like particle (VLP)-based vaccines are currently under development and have been shown to elicit systemic and mucosal immune responses when delivered intranasally. In the present study, we describe the use of a dry powder formulation (GelVac™) with an in situ gelling polysaccharide (GelSite™) extracted from Aloe vera for nasal delivery of a bivalent vaccine formulation containing both GI and GII...
2017: PloS One
https://www.readbyqxmd.com/read/28462527/dying-to-protect-cell-death-and-the-control-of-t-cell-homeostasis
#7
REVIEW
Kun-Po Li, Sharmila Shanmuganad, Kaitlin Carroll, Jonathan D Katz, Michael B Jordan, David A Hildeman
T cells play a critical role in immune responses as they specifically recognize peptide/MHC complexes with their T-cell receptors and initiate adaptive immune responses. While T cells are critical for performing appropriate effector functions and maintaining immune memory, they also can cause autoimmunity or neoplasia if misdirected or dysregulated. Thus, T cells must be tightly regulated from their development onward. Maintenance of appropriate T-cell homeostasis is essential to promote protective immunity and limit autoimmunity and neoplasia...
May 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28339574/arm-paralysis-after-routine-childhood-vaccinations-application-of-advanced-molecular-methods-to-the-causality-assessment-of-an-adverse-event-after-immunization
#8
Jana Shaw, Neal A Halsey, Adriana Weinberg, D Scott Schmid, Kirsten St George, William C Weldon, Michael Jordan, Patrick W Bryant, Philip S LaRussa, Deborah Y Bradshaw, Theresa Harrington, Anne Gershon
Post-licensure surveillance for adverse events following immunizations (AEFI) can identify rare complications of vaccinations and rigorous vaccine adverse event causality assessments can help to identify possible causal relationships. We report the development of arm paralysis after varicella vaccination in a 1-year-old child. Paralysis was initially presumed to be due to vOka because of the temporal relationship between vaccination and onset of arm weakness; however, molecular studies identified wild-type varicella zoster virus VZV (WT-VZV) in the CSF, leading the authors to conclude that WT-VZV was the probable cause...
January 25, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28330443/influenza-and-respiratory-syncytial-virus-in-infants-study-iris-of-hospitalized-and-non-ill-infants-aged-1-year-in-four-countries-study-design-and-methods
#9
Mark G Thompson, Danielle R Hunt, Ali K Arbaji, Artan Simaku, Veronica L Tallo, Holly M Biggs, Carolyn Kulb, Aubree Gordon, Ilham Abu Khader, Silvia Bino, Marilla G Lucero, Eduardo Azziz-Baumgartner, Pat Shifflett, Felix Sanchez, Basima I Marar, Ilirjana Bakalli, Eric A F Simões, Min Z Levine, Jennifer K Meece, Angel Balmaseda, Tareq M Al-Sanouri, Majlinda Dhimolea, Joanne N de Jesus, Natalie J Thornburg, Susan I Gerber, Lionel Gresh
BACKGROUND: This multi-country prospective study of infants aged <1 year aims to assess the frequency of influenza virus and respiratory syncytial virus (RSV) infections associated with hospitalizations, to describe clinical features and antibody response to infection, and to examine predictors of very severe disease requiring intensive care. METHODS/DESIGN: We are enrolling a hospital-based cohort and a sample of non-ill infants in four countries (Albania, Jordan, Nicaragua, and the Philippines) using a common protocol...
March 22, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28301234/minimum-infectious-dose-determination-of-the-arkansas-delmarva-poultry-industry-infectious-bronchitis-virus-vaccine-delivered-by-hatchery-spray-cabinet
#10
Christina M Leyson, Deborah A Hilt, Brian J Jordan, Mark W Jackwood
The Arkansas Delmarva Poultry Industry (ArkDPI) infectious bronchitis virus (IBV) vaccine is effective when administered by eye drop, where the vaccine virus is able to infect and replicate well in birds and is able to induce protection against homologous challenge. However, accumulating evidence indicates that the ArkDPI vaccine is ineffective when applied by hatchery spray cabinet using the same manufacturer-recommended dose per bird. For this study, we aimed to determine the minimum infectious dose for the spray-administered ArkDPI vaccine, which we designate as the dose that achieves the same level of infection and replication as the eye drop-administered ArkDPI vaccine...
March 2017: Avian Diseases
https://www.readbyqxmd.com/read/28286144/characterization-of-theileria-equi-genotypes-in-horses-in-israel-the-palestinian-authority-and-jordan
#11
Dafna Ketter-Ratzon, Sharon Tirosh-Levy, Yaarit Nachum-Biala, Tal Saar, Lara Qura'n, Doni Zivotofsky, Ziad Abdeen, Gad Baneth, Amir Steinman
Equine theileriosis caused by Theileria equi is endemic in the Middle East, where it causes a severe disease as well as widespread subclinical infection. The aim of this study was to evaluate the diversity of T. equi genotypes in Israel and the neighboring Palestinian Authority and Jordan. Blood samples from 355 horses from Israel, the Palestinian Authority and Jordan were tested for the prevalence of T. equi DNA. Two hundred and fourteen (60%) were found positive for T. equi infection by PCR. Of those, the 18S rRNA (1458bp) and the EMA-1 (745bp) genes of T...
March 4, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28192438/advances-in-neglected-tropical-disease-vaccines-developing-relative-potency-and-functional-assays-for-the-na-gst-1-alhydrogel-hookworm-vaccine
#12
Jill B Brelsford, Jordan L Plieskatt, Anna Yakovleva, Amar Jariwala, Brian P Keegan, Jin Peng, Pengjun Xia, Guangzhao Li, Doreen Campbell, Maria Victoria Periago, Rodrigo Correa-Oliveira, Maria Elena Bottazzi, Peter J Hotez, David Diemert, Jeffrey M Bethony
A new generation of vaccines for the neglected tropical diseases (NTDs) have now advanced into clinical development, with the Na-GST-1/Alhydrogel Hookworm Vaccine already being tested in Phase 1 studies in healthy adults. The current manuscript focuses on the often overlooked critical aspects of NTD vaccine product development, more specifically, vaccine stability testing programs. A key measure of vaccine stability testing is "relative potency" or the immunogenicity of the vaccine during storage. As with most NTD vaccines, the Na-GST-1/Alhydrogel Hookworm Vaccine was not developed by attenuation or inactivation of the pathogen (Necator americanus), so conventional methods for measuring relative potency are not relevant for this investigational product...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28181678/safety-and-immunological-efficacy-of-a-dna-vaccine-encoding-the-androgen-receptor-ligand-binding-domain-ar-lbd
#13
Brian M Olson, Eric S Bradley, Thomas Sawicki, Weixiong Zhong, Erik A Ranheim, Jordan E Bloom, Viswa T Colluru, Laura E Johnson, Brian T Rekoske, Jens C Eickhoff, Douglas G McNeel
BACKGROUND: The androgen receptor (AR) is a key oncogenic driver of prostate cancer, and has been the primary focus of prostate cancer treatment for several decades. We have previously demonstrated that the AR is also an immunological target antigen, recognized in patients with prostate cancer, and targetable by means of vaccines in rodent models with delays in prostate tumor growth. The current study was performed to determine the safety and immunological efficacy of a GMP-grade plasmid DNA vaccine encoding the ligand-binding domain (LBD) of the AR, pTVG-AR...
May 2017: Prostate
https://www.readbyqxmd.com/read/28104650/genome-sequences-of-diverse-human-cytomegalovirus-strains-with-utility-in-drug-screening-and-vaccine-evaluation
#14
Kathleen Corcoran, Carly J Sherrod, Ellen F Perkowski, Jordan Texier, Fengsheng Li, I-Ming Wang, Michael McVoy, Tong-Ming Fu, Dirk P Dittmer
Cytomegalovirus displays genetic heterogeneity, which has implications for antiviral and vaccine development. Many studies have focused on laboratory isolates that have been extensively adapted for growth on fibroblasts. Here, we report whole-genome sequences for 10 human cytomegalovirus (HCMV) strains that readily grow on ARPE-19 human retinal pigment epithelial cells.
January 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28103684/activation-pathway-of-a-nucleoside-analog-inhibiting-respiratory-syncytial-virus-polymerase
#15
Paul C Jordan, Sarah K Stevens, Yuen Tam, Ryan P Pemberton, Shuvam Chaudhuri, Antitsa D Stoycheva, Natalia Dyatkina, Guangyi Wang, Julian A Symons, Jerome Deval, Leo Beigelman
Human respiratory syncytial virus (RSV) is a negative-sense RNA virus and a significant cause of respiratory infection in infants and the elderly. No effective vaccines or antiviral therapies are available for the treatment of RSV. ALS-8176 is a first-in-class nucleoside prodrug inhibitor of RSV replication currently under clinical evaluation. ALS-8112, the parent molecule of ALS-8176, undergoes intracellular phosphorylation, yielding the active 5'-triphosphate metabolite. The host kinases responsible for this conversion are not known...
January 20, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28100498/the-predominant-cd4-th1-cytokine-elicited-to-chlamydia-trachomatis-infection-in-women-is-tumor-necrosis-factor-alpha-and-not-interferon-gamma
#16
Stephen J Jordan, Kanupriya Gupta, Brian M O Ogendi, Rakesh K Bakshi, Richa Kapil, Christen G Press, Steffanie Sabbaj, Jeannette Y Lee, William M Geisler
Chlamydia trachomatis infection is the most prevalent bacterial sexually transmitted infection and can cause significant reproductive morbidity in women. There is insufficient knowledge of C. trachomatis-specific immune responses in humans, which could be important in guiding vaccine development efforts. In contrast, murine models have clearly demonstrated the essential role of T helper type 1 (Th1) cells, especially interferon gamma (IFN-γ)-producing CD4(+) T cells, in protective immunity to chlamydia. To determine the frequency and magnitude of Th1 cytokine responses elicited to C...
April 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28054443/risk-mitigation-of-emerging-zoonoses-hendra-virus-and-non-vaccinating-horse-owners
#17
J Manyweathers, H Field, D Jordan, N Longnecker, K Agho, C Smith, M Taylor
Hendra virus was identified in horses and humans in 1994, in Queensland, Australia. Flying foxes are the natural host. Horses are thought to acquire infection by direct or indirect contact with infected flying fox urine. Humans are infected from close contact with infected horses. To reduce risk of infection in horses and humans, Australian horse owners are encouraged to vaccinate horses against the virus and adopt property risk mitigation practices that focus on reducing flying fox horse contact and contamination of horses' environment with flying fox bodily fluids...
January 4, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/27931293/pulmonologist-perspectives-regarding-diagnosis-and-management-of-primary-immunodeficiency-diseases
#18
Jordan S Orange, Javeed Akhter, Filiz O Seeborg, Marcia Boyle, Christopher Scalchunes, Vivian Hernandez-Trujillo
BACKGROUND: The time from symptom onset to diagnosis for patients with primary immunodeficiency diseases (PIDD) is an average of 12 years, but prompt diagnosis and treatment can promote best outcomes. OBJECTIVE: Because the manifestations of PIDD are often sinopulmonary in nature, patients with undiagnosed PIDD are frequently referred to pulmonologists. This study sought to identify opportunities among these specialists to improve diagnosis and clinical management of patients with PIDD...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27836775/insights-from-molecular-structure-predictions-of-the-infectious-bronchitis-virus-s1-spike-glycoprotein
#19
Christina Lora M Leyson, Brian J Jordan, Mark W Jackwood
Infectious bronchitis virus is an important respiratory pathogen in chickens. The IBV S1 spike is a viral structural protein that is responsible for attachment to host receptors and is a major target for neutralizing antibodies. To date, there is no experimentally determined structure for the IBV S1 spike. In this study, we sought to find a predicted tertiary structure for IBV S1 using I-TASSER, which is an automated homology modeling platform. We found that the predicted structures obtained were robust and consistent with experimental data...
December 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27748651/acute-respiratory-disease-in-us-army-trainees-3-years-after-reintroduction-of-adenovirus-vaccine-1
#20
Nakia S Clemmons, Zachary D McCormic, Joel C Gaydos, Anthony W Hawksworth, Nikki N Jordan
The 1999 cessation of vaccination against adenovirus types 4 and 7 among US Army trainees resulted in reemergence of acute respiratory disease (ARD) outbreaks. The 2011 implementation of a replacement vaccine led to dramatic and sustained decreases in ARD cases, supporting continuation of vaccination in this population at high risk for ARD.
January 2017: Emerging Infectious Diseases
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