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REVIEW
Mahesh Chandra, Ansar Ahmad Paray
Pregnancy causes physiological changes that support the growing fetus and get the mother ready for labor and delivery. Some of these modifications affect biochemical levels; they are normally stable, while others could imitate symptoms of illness. It is critical to distinguish between pathology associated with disease and typical physiological changes. This review article focuses on the significant changes that occur throughout a typical pregnancy.
March 2024: Yale Journal of Biology and Medicine
#22
JOURNAL ARTICLE
Joris A J Osinga, Yindi Liu, Tuija Männistö, Marina Vafeiadi, Fang-Biao Tao, Bijay Vaidya, Tanja G M Vrijkotte, Lorena Mosso, Judit Bassols, Abel López-Bermejo, Laura Boucai, Ashraf Aminorroaya, Ulla Feldt-Rasmussen, Aya Hisada, Jun Yoshinaga, Maarten A C Broeren, Sachiko Itoh, Reiko Kishi, Ghalia Ashoor, Liangmiao Chen, Flora Veltri, Xuemian Lu, Peter N Taylor, Suzanne J Brown, Leda Chatzi, Polina V Popova, Elena N Grineva, Farkhanda Ghafoor, Amna Pirzada, Maryam Kianpour, Emily Oken, Eila Suvanto, Andrew Hattersley, Marisa Rebagliato, Isolina Riaño-Galán, Amaia Irizar, Martine Vrijheid, Juana Maria Delgado-Saborit, Ana Fernández-Somoano, Loreto Santa-Marina, Kristien Boelaert, Gabriela Brenta, Rima Dhillon-Smith, Chrysoula Dosiou, Jennifer L Eaton, Haixia Guan, Sun Y Lee, Spyridoula Maraka, Lilah F Morris-Wiseman, Caroline T Nguyen, Zhongyan Shan, Mònica Guxens, Victor J M Pop, John P Walsh, Kypros H Nicolaides, Mary E D'Alton, W Edward Visser, David M Carty, Christian Delles, Scott M Nelson, Erik K Alexander, Layal Chaker, Glenn E Palomaki, Robin P Peeters, Sofie Bliddal, Kun Huang, Kris G Poppe, Elizabeth N Pearce, Arash Derakhshan, Tim I M Korevaar
Background: International guidelines recommend targeted screening to identify gestational thyroid dysfunction. However, currently used risk factors have questionable discriminative ability. We quantified the risk for thyroid function test abnormalities for a subset of risk factors currently used in international guidelines. Methods: We included prospective cohort studies with data on gestational maternal thyroid function and potential risk factors (maternal age, body mass index [BMI], parity, smoking status, pregnancy through in vitro fertilization, twin pregnancy, gestational age, maternal education, and thyroid peroxidase antibody [TPOAb] or thyroglobulin antibody [TgAb] positivity)...
March 28, 2024: Thyroid: Official Journal of the American Thyroid Association
#23
JOURNAL ARTICLE
Samantha Lai-Ka Lee, Quynh-Nhu Nguyen, Cindy Ho, Simon James, Amreeta Kaur, Angelina Lim, Karin Tiedemann, Margaret Zacharin
CONTEXT: A rare, large single centre study covering all long-term health outcomes of paediatric allogeneic HSCT survivors, to provide comprehensive local data, and identify gaps and future directions for improved care. OBJECTIVE: To document endocrine sequelae and other late effects of all HSCT recipients. DESIGN: Retrospective review. SETTING: Royal Children's Hospital Melbourne. PATIENTS: 384 children and adolescents received HSCT...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
#24
JOURNAL ARTICLE
Vijay Sheker Reddy Danda, Piyush Lodha, Srinivas Rao Paidipally, Sandeep Reddy Devireddy
INTRODUCTION: Accurate diagnosis of the etiology of thyrotoxicosis in pregnancy is important to guide appropriate treatment. The role of thyroid blood flow velocities by color Doppler to differentiate between Graves' disease (GD) in pregnancy and gestational transient thyrotoxicosis (GTT) is not well explored. This study evaluated inferior thyroid artery (ITA)-peak systolic velocity (PSV) as a marker for differential diagnosis of thyrotoxicosis in pregnancy. METHODS: Fifty-six pregnant patients with thyrotoxicosis (30 with GTT and 26 with GD) along with 30 age-matched healthy euthyroid pregnant subjects were enrolled...
2024: Indian Journal of Endocrinology and Metabolism
#25
JOURNAL ARTICLE
Xuan Huang, Chen Zhang, Jialei Zhu, Yueyan Li, Jing Tang
OBJECTIVE: The study aimed to review the oncological characteristics and treatment of pregnancy-associated cancers and analyze the obstetric and neonatal outcomes to provide evidence-based recommendations for reproductive function preservation, oncological treatment, and obstetric management. METHODS: We conducted an observational retrospective cohort study among pregnant patients with cancer in 7 Chinese tertiary A hospitals from 2003 to 2021. We conducted multiple logistic regression to determine the influence of various factors on preterm birth and small-for-gestational-age infants, log-binomial regression to analyze temporal changes, and χ² tests to explore the effects of cancer type/treatment...
March 11, 2024: Journal of Gynecologic Oncology
#26
JOURNAL ARTICLE
Fatih Ates, Ömer Faruk Topaloglu, Ozlem Secilmis, Görkem Aktas, Sibel Ozler, Mehmet Sedat Durmaz, Mustafa Koplay
PURPOSE: We aimed to investigate maternal thyroid parenchymal vascularity with 2-dimensional color superb microvascular imaging vascularization index (2D-cSMIVI) levels and thyroid gland volume in the first, second and third trimesters. METHODS: This longitudinal prospective study was carried out with participants selected from 30 healthy asymptomatic pregnant women. Ultrasonography (US) for the thyroid gland was performed in each trimester. The vascularization index (VI) values obtained by manually drawing the contours of the thyroid parenchyma in the longutidinal plane, using the free region of interest (ROI) with 2DcSMIVI mode...
March 20, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#27
JOURNAL ARTICLE
Hui Zhu, Jie Cai, Hongyi Liu, Zhijia Zhao, Yanming Chen, Penghao Wang, Tao Chen, Da He, Xiang Chen, Jin Xu, Lindan Ji
BACKGROUND: China's fertility policy has dramatically changed in the past decade with the successive promulgation of the partial two-child policy, universal two-child policy and three-child policy. The trajectories of maternal and neonatal health accompanied the changes in fertility policy are unknown. METHODS: We obtained data of 280 203 deliveries with six common pregnancy complications and thirteen perinatal outcomes between 2010 and 2021 in eastern China...
March 22, 2024: Journal of Global Health
#28
REVIEW
Yu Song, Yu Bai, Cong Liu, Xiaodan Zhai, Le Zhang
Autoimmune thyroiditis (AITD) is a T-cell-mediated, organ- specific autoimmune disease caused by interactions between genetic and environmental factors. Patients with AITD show thyroid lymphocyte infiltration and an increase in the titer of thyroid autoimmune antibodies, thereby altering the integrity of thyroid follicle epithelial cells and dysregulating their metabolism and immune function, leading to a decrease in multi-tissue metabolic activity. Research has shown that patients with AITD have a significantly higher risk of adverse pregnancy outcomes, such as infertility and miscarriage...
2024: Frontiers in Cellular and Infection Microbiology
#29
JOURNAL ARTICLE
S Menotti, C Mura, S Raia, L Bergianti, S De Carolis, D M Romeo, C A Rota, A Pontecorvi
PURPOSE: Overt hypothyroidism during pregnancy is linked to various obstetric complications, such as premature birth and fetal death. While some studies have shown that maternal hypothyroidism can impact a child's Intelligence Quotient (IQ) and language development, findings are controversial. The aim of this study was to explore the connection between treated maternal hypothyroidism during pregnancy and offspring neurodevelopment, focusing on learning and language and examining related maternal obstetric complications...
March 18, 2024: Journal of Endocrinological Investigation
#30
JOURNAL ARTICLE
Zahid Agaoglu, Munire Funda Cevher Akdulum, Merve Ozturk Agaoglu, Konul Mursel, Recep Onur Karabacak
AIM: To investigate the effects of levothyroxine and prednisolone treatment, or in combination, on positive thyroid autoantibodies in infertile patients undergoing in vitro fertilization (IVF) therapy. METHODS: This retrospective study included a total of 190 patients with positive thyroid autoantibodies (anti-T and anti-TPO) who underwent IVF treatment between January 2008 and March 2016. Patients were divided into four groups: group 1-levothyroxine group (n = 50), group 2-prednisolone group (n = 50), group 3-levothyroxine and prednisolone combination (n = 25), group 4-control group (n = 65)...
March 16, 2024: Journal of Obstetrics and Gynaecology Research
#31
Nidhi Gupta, Lauren Graham, Matthew Carpenter, Gunjan Y Gandhi
Thyroid storm due to gestational trophoblastic disease (GTD) with metastatic choriocarcinoma is a rare but potentially life-threatening endocrine emergency. We report on a woman with molar pregnancy and metastatic choriocarcinoma who presented with thyroid storm (Burch-Wartofsky point scale of 45) a few weeks after the evacuation of GTD. She was initially managed with intravenous hydrocortisone, oral propylthiouracil (PTU), and esmolol infusion. After stabilization in the intensive care unit, 10 cycles of chemotherapy with etoposide, methotrexate, leucovorin, dactinomycin, and cyclophosphamide (EMA-CO) were initiated for stage 4 choriocarcinoma with brain and lung metastases...
March 2024: JCEM Case Rep
#32
JOURNAL ARTICLE
Nicole Lafontaine, Suzanne J Brown, Petros Perros, Enrico Papini, Endre V Nagy, Roberto Attanasio, Laszlo Hegedüs, John P Walsh
OBJECTIVE: Hypothyroidism is a common endocrine condition usually managed with levothyroxine (LT4). However, controversy remains around the use of liothyronine (LT3). We aimed to investigate the practices of Australian endocrinologists when managing patients with hypothyroidism, their use of LT3 + LT4 combination therapy and use of thyroid hormones in euthyroid patients. DESIGN AND PARTICIPANTS: Members of the Endocrine Society of Australia (ESA) were invited to participate in an online questionnaire...
March 11, 2024: Clinical Endocrinology
#33
JOURNAL ARTICLE
Mairéad T Crowley, Eirena Goulden, Begona Sanchez-Lechuga, Aileen Fleming, Maria Kennelly, Ciara McDonnell, Maria M Byrne
BACKGROUND: Heterozygous insulin receptor mutations (INSR) are associated with insulin resistance, hyperglycaemia and hyperinsulinaemic hypoglycaemia in addition to hyperandrogenism and oligomenorrhoea in women. Numerous autosomal dominant heterozygous mutations involving the INSR β-subunit tyrosine kinase domain resulting in type A insulin resistance have been previously described. We describe the phenotype, obstetric management and neonatal outcomes in a woman with type A insulin resistance caused by a mutation in the β-subunit of the INSR...
March 10, 2024: Clinical Diabetes and Endocrinology
#34
REVIEW
Delini Devi Ramadras, Noor Azlin Azraini Che Soh Yusof, Najib Majdi Yaacob, Wan Azman Wan Norlina, Abdul Hamid Hanisah
Infertility affects millions of people of reproductive age worldwide. Thyroid hormones and prolactin (PRL) affect reproduction and pregnancy; therefore, these two hormones influence fertility. This systematic review and meta-analysis aimed to summarise the strength of the correlation between serum PRL and thyroid stimulating hormone (TSH) in infertile women and to explore selected factors influencing the correlation. We conducted a systematic search of online databases (PubMed, Scopus, ScienceDirect, SAGE and Google Scholar) from inception until March 2021 and a manual search of the bibliographies of the included studies to identify relevant publications...
February 2024: Malaysian Journal of Medical Sciences: MJMS
#35
JOURNAL ARTICLE
Yuchao Zhang, Jiaheng Li, Yanli Liu, Zhen Li, Yichun Guan
PURPOSE: Controlled ovarian hyperstimulation (COH) has been reported to affect thyroid function; however, the impact of thyroid-stimulating hormone (TSH) levels during COH on embryo development and early reproductive outcomes has largely not been determined. Therefore, the aim of the present study was to investigate whether TSH levels are associated with COH and impact early reproductive outcomes in preconceptionally euthyroid women. METHODS: This was a prospective cohort study...
March 6, 2024: Hormones: International Journal of Endocrinology and Metabolism
#36
JOURNAL ARTICLE
Divya Nayani, Sampath Kumar Singh, K V N Durga Prasad, Rahul Kumar Rahul Pitale Ashok
Lingual thyroid is a rare, abnormal ectopic thyroid tissue seen at the base of the tongue. It is a rare embryological anomaly caused by the failure of the descendence of the thyroid gland from the foramen caecum to its normal prelaryngeal area. The main aim of our study is to discuss recent advancements in the management of lingual thyroid using coblation technology. We are discussing the prospective study of 12 lingual thyroid cases that came to the government ENT hospital, Koti, in Hyderabad, from July 2016 to July 2023...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
#37
JOURNAL ARTICLE
Caichen Zhong, Juliette Rando, Marisa A Patti, Joseph M Braun, Aimin Chen, Yingying Xu, Bruce P Lanphear, Kimberly Yolton, Lisa A Croen, M Daniele Fallin, Irva Hertz-Picciotto, Craig J Newschaffer, Kristen Lyall
Thyroid hormones are essential for neurodevelopment. Few studies have considered associations with quantitatively measured autism spectrum disorder (ASD)-related traits, which may help elucidate associations for a broader population. Participants were drawn from two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI), enrolling pregnant women who already had a child with ASD, and the Health Outcomes and Measures of the Environment (HOME) Study, following pregnant women from the greater Cincinnati, OH area...
March 4, 2024: Autism Research: Official Journal of the International Society for Autism Research
#38
REVIEW
Qiwei Li, Zhiyun Zhang, Jiajia Fang
Epilepsy is a prevalent neurological disorder among women globally, often requiring long-term treatment. Hormonal fluctuations in women with epilepsy (WWE) can have reciprocal effects on epilepsy and antiseizure medications (ASMs), posing significant challenges for WWE. Notably, WWE commonly experience endocrine alterations such as thyroid dysfunctions, low bone metabolism, and reproductive hormone irregularities. On the one hand, the presence of hormones in women with epilepsy affects their susceptibility to epilepsy as well as the metabolism of antiseizure medications in various ways...
2024: Neuropsychiatric Disease and Treatment
#39
REVIEW
Ethan Slouha, Kaitlyn M Gates, Hanin Al-Geizi, Esther Baah, Lucy A Clunes, Theofanis F Kollias
Gestational diabetes mellitus (GDM) is one of the most common endocrine disorders to occur during pregnancy due to the increase in circulating human placental lactogen (hPL) and possible beta-cell sensitivity. While GDM can be managed either with diet and exercise or pharmacological interventions, it is associated with significant maternal and neonatal complications. Maternal complications include short- and long-term conditions such as pre-eclampsia, preterm birth, arrest of labor, future development of type 2 diabetes mellitus (T2DM), and cardiovascular disorders...
January 2024: Curēus
#40
REVIEW
Jalormy S Joshi, Amardeep Shanoo, Nainita Patel, Aishwarya Gupta
This comprehensive review delves into the multifaceted landscape of thyroid disorders during pregnancy, exploring their impact from conception to postpartum considerations. Key findings highlight the intricate interplay between maternal thyroid health and fetal development, emphasizing the critical importance of timely screening and targeted interventions. The evolving landscape of research and technology suggests a paradigm shift toward personalized approaches in clinical practice, emphasizing integrated care models and the integration of telehealth platforms...
February 2024: Curēus
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