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JOURNAL ARTICLE
Li Zhang, Sheng Zhao, Sisi Wu, Yan Luo, Yinfang Wang, Xiaotian Fu, Dan Wang, Yuhan Wu
OBJECTIVE: To explore the application of four-dimensional pelvic floor ultrasound in the diagnosis of postpartum pelvic floor dysfunction (PFD) and evaluation of curative effect. METHODS: A total of 100 patients with postpartum PFD undergoing vaginal delivery in the hospital were enrolled as the research objects between January 2020 and January 2023. A total of 100 postpartum women with good pelvic floor muscle function during the same period were enrolled as a control group...
January 1, 2024: Alternative Therapies in Health and Medicine
#22
JOURNAL ARTICLE
Cong Fan, Nike He, Jifeng Yuan
The rapid and accurate detection of fungal pathogens is of utmost importance in the fields of healthcare, food safety, and environmental monitoring. In this study, we implemented a cascaded amplifying circuit in Saccharomyces cerevisiae to improve the G protein-coupled receptor (GPCR) mediated fungal detection. The GPCR signaling pathway was coupled with the galactose-regulated (GAL) system and a positive feedback loop was implemented to enhance the performance of yeast biosensor. We systematically compared four generations of biosensors for detecting the mating pheromone of Candida albicans, and the best biosensor exhibited the limit of detection (LOD) as low as 0...
January 20, 2024: Biosensors & Bioelectronics
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JOURNAL ARTICLE
Minyao Wang, Zhongze Lou, Yanbin Hou, Liping Song, Lingli Zhang, Yu Zhao, Liemin Ruan, Youju Huang
Nowadays, the diagnose of depression mainly relies on clinical examination while impossible to accurately evaluate the occurrence of depression. Chemical approaches are captivating to analyze stress biomarkers for feedbacking body's endocrine response to stress stimuli. However, it remains challenging in exploring accurate, reliable and sensitive approaches. Herein, we rationally design a newly SERS platform with integrated hotspots engineering and analyte strategy to achieve highly sensitive analysis for estrogen, a typical depression biomarker in adolescent female...
January 22, 2024: Biosensors & Bioelectronics
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JOURNAL ARTICLE
Ying Deng, Tianci Zhou, Kai Hu, Ying Peng, Xuemei Jia, Jie Yang, Genxi Li
Intelligent artificial DNA circuits have emerged as a promising approach for modulating signaling pathways and signal transduction through rational design, which may contribute to comprehensively realizing biomolecular sensing of organisms. In this work, we have fabricated an electrochemical biosensor for the sensitive and accurate detection of ovarian cancer-derived exosomes by constructing an entropy-driven autocatalytic DNA circuit (EADC). Specifically, the robust EADC is prepared by the self-assembly of well-designed DNA probes, and upon stimulation of the presence of ovarian cancer cells-derived exosomes, numerous inputs can be produced to feedback and accelerate the reaction...
January 23, 2024: Biosensors & Bioelectronics
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JOURNAL ARTICLE
Mohammad Mir, Jiawen Chen, Aneri Patel, Meghan R Pinezich, Brandon A Guenthart, Gordana Vunjak-Novakovic, Jinho Kim
OBJECTIVE: Robot-assisted minimally invasive surgery remains limited by the absence of haptic feedback, which surgeons routinely rely on to assess tissue stiffness. This limitation hinders surgeons' ability to identify and treat abnormal tissues, such as tumors, during robotic surgery. METHODS: To address this challenge, we developed a robotic tissue palpation device capable of rapidly and noninvasively quantifying the stiffness of soft tissues, allowing surgeons to make objective and data-driven decisions during minimally invasive procedures...
January 23, 2024: IEEE Transactions on Bio-medical Engineering
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JOURNAL ARTICLE
Yubo Zhang, Lintao Wang, Lin Li, Xiaoming Wang, Shuai He
The positioning accuracy of spacecraft in orbit is easily affected by low-frequency micro-vibrations of the environment and internal disturbances caused by the payload. Inspired by the neck structure of birds, this study devised a piezo-driven active vibration isolation unit with high stiffness. First, a dynamic model and two-sensor feedback control method for the isolation unit were developed, and the isolation mechanism and anti-disturbance characteristics were analyzed. Further, the stability of the closed-loop was verified...
January 4, 2024: Biomimetics
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JOURNAL ARTICLE
Keith R Skene
In this paper we explore the relevance and integration of system theory and thermodynamics in terms of the Earth system. It is proposed that together, these fields explain the evolution, organization, functionality and directionality of life on Earth. We begin by summarizing historical and current thinking on the definition of life itself. We then investigate the evidence for a single unit of life. Given that any definition of life and its levels of organization are intertwined, we explore how the Earth system is structured and functions from an energetic perspective, by outlining relevant thermodynamic theory relating to molecular, metabolic, cellular, individual, population, species, ecosystem and biome organization...
January 18, 2024: Bio Systems
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JOURNAL ARTICLE
Jared Lawson, Madison Veliky, Colette P Abah, Mary S Dietrich, Rohan Chitale, Nabil Simaan
OBJECTIVE: The objective of this work is to introduce and demonstrate the effectiveness of a novel sensing modality for contact detection between an off-the-shelf aspiration catheter and a thrombus. METHODS: A custom robotic actuator with a pressure sensor was used to generate an oscillatory vacuum excitation and sense the pressure inside the extracorporeal portion of the catheter. Vacuum pressure profiles and robotic motion data were used to train a support vector machine (SVM) classification model to detect contact between the aspiration catheter tip and a mock thrombus...
January 19, 2024: IEEE Transactions on Bio-medical Engineering
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JOURNAL ARTICLE
Jamal T Hamdi, Shadi Munshi, Sufyan Azam, Aiman Omer
Robotic surgery started nearly 30 years ago. It has achieved telepresence and the performance of repetitive, precise, and accurate tasks. The "master-slave" robotic system allows control of manipulators by surgeon at distant site. Robotic surgical fingers were developed to allow surgeons to move them with accuracy through sensors fixed on surgeon's hand. Also, haptic sensors were developed to allow transmission of sensation from robotic finger to surgeon's finger. A complete system of a, 3D printed by a stereolithography (SLA) 3D printer, robotic surgical finger with haptic feedback system is proposed...
January 18, 2024: Journal of Robotic Surgery
#30
JOURNAL ARTICLE
Rhesus monkeys learn to control a directional-key inspired brain machine interface via bio-feedback.
Chenguang Zhang, Hao Wang, Shaohua Tang, Zheng Li
Brain machine interfaces (BMI) connect brains directly to the outside world, bypassing natural neural systems and actuators. Neuronal-activity-to-motion transformation algorithms allow applications such as control of prosthetics or computer cursors. These algorithms lie within a spectrum between bio-mimetic control and bio-feedback control. The bio-mimetic approach relies on increasingly complex algorithms to decode neural activity by mimicking the natural neural system and actuator relationship while focusing on machine learning: the supervised fitting of decoder parameters...
2024: PloS One
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JOURNAL ARTICLE
Dicheng Chen, Meijin Lin, Huiting Liu, Jiayu Li, Yirong Zhou, Taishan Kang, Liangjie Lin, Zhigang Wu, Jiazheng Wang, Jing Li, Jianzhong Lin, Xi Chen, Di Guo, Xiaobo Qu
OBJECTIVE: Magnetic Resonance Spectroscopy (MRS) is an important technique for biomedical detection. However, it is challenging to accurately quantify metabolites with proton MRS due to serious overlaps of metabolite signals, imperfections because of non-ideal acquisition conditions, and interference with strong background signals mainly from macromolecules. The most popular method, LCModel, adopts complicated non-linear least square to quantify metabolites and addresses these problems by designing empirical priors such as basis-sets, imperfection factors...
January 15, 2024: IEEE Transactions on Bio-medical Engineering
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JOURNAL ARTICLE
Orna Zagoory-Sharon, Karen Yirmiya, Itai Peleg, Ortal Shimon-Raz, Rachel Sanderlin, Ruth Feldman
Breastfeeding has long been known to improve infants' health and mental development and to enhance the mother-infant bond, but much less research focused on the biological composition of breast milk and its associations with the infant's biomarkers and social development. In this exploratory study, we measured oxytocin (OT) and secretory immunoglobulin-A (s-IgA), the most abundant antibody in breast milk, and evaluated their associations with the same biomarkers in infant saliva and, consequently, with infant social engagement behavior...
February 2024: Comprehensive psychoneuroendocrinology
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JOURNAL ARTICLE
Mengzhen Nie, Jingyu Wang, Zeyao Chen, Chenkai Cao, Kechun Zhang
BACKGROUND: L-phenylalanine is an essential amino acid with various promising applications. The microbial pathway for L-phenylalanine synthesis from glucose in wild strains involves lengthy steps and stringent feedback regulation that limits the production yield. It is attractive to find other candidates, which could be used to establish a succinct and cost-effective pathway for L-phenylalanine production. Here, we developed an artificial bioconversion process to synthesize L-phenylalanine from inexpensive aromatic precursors (benzaldehyde or benzyl alcohol)...
January 5, 2024: Microbial Cell Factories
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JOURNAL ARTICLE
Shintarou Kudo, Mizuki Hatanaka, Seiya Kanazawa, Keisuke Hirakawa, Shigeyuki Hara, Masahiro Tsutsumi
BACKGROUND: Short foot exercises (SFE) take a long time to master and require a feedback tool to improve motor learning. OBJECTIVE: This study aimed to investigate the effect of bio-feedback of talonavicular joint movements in learning SFE with ultrasound (US) imaging. METHODS: This study included thirty-one healthy volunteers and was designed as a double-blind randomized control trial. Subjects were randomly assigned to one of two groups: the control group, which performed SFE under verbal instruction, and the US bio-feedback (USBF) group, which performed SFE with real-time bio-feedback of the talonavicular joint alignment...
December 13, 2023: Journal of Back and Musculoskeletal Rehabilitation
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JOURNAL ARTICLE
Elizabeth A Rochon, Maimouna Sy, Mirelle Phillips, Erik Anderson, Evan Plys, Christine Ritchie, Ana-Maria Vranceanu
BACKGROUND: Alzheimer disease and related dementias are debilitating and incurable diseases. Persons with dementia and their informal caregivers (ie, dyads) experience high rates of emotional distress and negative health outcomes. Several barriers prevent dyads from engaging in psychosocial care including cost, transportation, and a lack of treatments that target later stages of dementia and target the dyad together. Technologically informed treatment and serious gaming have been shown to be feasible and effective among persons living with dementia and their care partners...
December 29, 2023: JMIR Research Protocols
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JOURNAL ARTICLE
Hongxin Wang, Zhiyan Zhong, Fang Lei, Jigen Peng, Shigang Yue
Small moving objects at far distance always occupy only one or a few pixels in image and exhibit extremely limited visual features, which bring great challenges to motion detection. Highly evolved visual systems endow flying insects with remarkable ability to pursue tiny mates and prey, providing a good template to develop image processing method for small target motion detection. The insects' excellent sensitivity to small moving objects is believed to come from a class of specific neurons called small target motion detectors (STMDs)...
December 27, 2023: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
#37
REVIEW
Emma Snapes, Jonas J Astrin, Nina Bertheussen Krüger, Gregory H Grossman, Ellen Hendrickson, Nicola Miller, Cathy Seiler
The recently published fifth edition of the International Society for Biological and Environmental Repositories (ISBER) Best Practices signifies a pivotal milestone in navigating the complexities of repository management. Repositories operate within a constantly evolving landscape influenced by the changing fields of biospecimen science, technology, legal requirements, and ethical considerations. This dynamic is further amplified by unprecedented local and global challenges, such as pandemics, conflicts, and supply chain disruptions...
December 2023: Biopreservation and Biobanking
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JOURNAL ARTICLE
Annemieke De Wilde
No abstract text is available yet for this article.
December 2023: Biopreservation and Biobanking
#39
JOURNAL ARTICLE
Moritz Bender, Andreas Escher, Barbara Messner, Michael Rohrich, Michael Bernhard Fischer, Christoph Hametner, Gunther Laufer, Ulrich Kertzscher, Daniel Zimpfer, Stefan Jakubek, Marcus Granegger
OBJECTIVE: Conventional mock circulatory loops (MCLs) cannot replicate realistic hemodynamic conditions without inducing blood trauma. This constrains in-vitro hemocompatibility examinations of blood pumps to static test loops that do not mimic clinical scenarios. This study aimed at developing an atraumatic MCL based on a hardware-in-the-loop concept (H-MCL) for realistic hemocompatibility assessment. METHODS: The H-MCL was designed for 450±50 ml of blood with the polycarbonate reservoirs, the silicone/polyvinyl-chloride tubing, and the blood pump under investigation as the sole blood-contacting components...
December 22, 2023: IEEE Transactions on Bio-medical Engineering
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JOURNAL ARTICLE
Emma M Harding-Esch, Clara R Burgert-Brucker, Cristina Jimenez, Ana Bakhtiari, Rebecca Willis, Michael Dejene Bejiga, Caleb Mpyet, Jeremiah Ngondi, Sarah Boyd, Mariamo Abdala, Amza Abdou, Yilikal Adamu, Addisu Alemayehu, Wondu Alemayehu, Tawfik Al-Khatib, Sue-Chen Apadinuwe, Naomie Awaca, Marcel S Awoussi, Gilbert Baayendag, Mouctar Dieng Badiane, Robin L Bailey, Wilfrid Batcho, Zulficar Bay, Assumpta Bella, Nassirou Beido, Yak Yak Bol, Clarisse Bougouma, Christopher J Brady, Victor Bucumi, Robert Butcher, Risiate Cakacaka, Anaseini Cama, Mamoudou Camara, Eunice Cassama, Shorai Grace Chaora, Amel Chenaoui Chebbi, Alvin Blessings Chisambi, Brian Chu, Abdulai Conteh, Sidi Mohamed Coulibaly, Paul Courtright, Abdi Dalmar, Tran Minh Dat, Thully Davids, Mohamed El Amine Djaker, Maria de Fátima Costa Lopes, Djore Dézoumbé, Sarity Dodson, Philip Downs, Stephanie Eckman, Bilghis Elkhair Elshafie, Mourad Elmezoghi, Ange Aba Elvis, Paul Emerson, Emilienne Ee Epée, Daniel Faktaufon, Mawo Fall, Aréty Fassinou, Fiona Fleming, Rebecca Flueckiger, Koizan Kadjo Gamael, Mackline Garae, Jambi Garap, Katie Gass, Genet Gebru, Michael M Gichangi, Emanuele Giorgi, André Goépogui, Daniela Vaz Ferreira Gómez, Diana Paola Gómez Forero, Emily W Gower, Anna Harte, Rob Henry, Harvy Alberto Honorio-Morales, Dunera R Ilako, Amadou Alfa Bio Issifou, Ellen Jones, George Kabona, Martin Kabore, Boubacar Kadri, Khumbo Kalua, Sarjo Kebba Kanyi, Shambel Kebede, Fikreab Kebede, Jeremy D Keenan, Amir B Kello, Asad Aslam Khan, Houria Khelifi, Janvier Kilangalanga, Sung Hye Kim, Robert Ko, Susan Lewallen, Thomas Lietman, Makoy Samuel Yibi Logora, Yuri A Lopez, Chad MacArthur, Colin Macleod, Felix Makangila, Brehima Mariko, Diana L Martin, Michael Masika, Patrick Massae, Marilia Massangaie, Hadley S Matendechero, Tsedeke Mathewos, Siobhain McCullagh, Aboulaye Meite, Elsa Palma Mendes, Hirpa M Abdi, Hollman Miller, Abdellahi Minnih, Sailesh Kumar Mishra, Tuduetso Molefi, Aryc Mosher, Nerkoua M'Po, Francis Mugume, Robson Mukwiza, Consity Mwale, Stephen Mwatha, Upendo Mwingira, Scott D Nash, Christophe Nassa, Nebiyu Negussu, Cece Nieba, Jean Claude Noah Noah, Christian O Nwosu, Nicholas Olobio, Rapheal Opon, Alexandre Pavluck, Isaac Phiri, Merelesita Rainima-Qaniuci, Kristen K Renneker, Martha Idalí Saboyá-Díaz, Fatoumata Sakho, Salimato Sanha, Virginia Sarah, Boubacar Sarr, Celia L Szwarcwald, Ahmad Shah Salam, Shekhar Sharma, Fikre Seife, Gloria Marina Serrano Chavez, Mactar Sissoko, Henis Mior Sitoe, Oliver Sokana, Fentahun Tadesse, Fasiah Taleo, Sandra Liliana Talero, Youcef Tarfani, Amsayaw Tefera, Rabebe Tekeraoi, Andeberhan Tesfazion, Abubaker Traina, Lamine Traoré, Julián Trujillo-Trujillo, Edridah M Tukahebwa, Praveen Vashist, Ernest B Wanyama, Supriya D P Warusavithana, Titus K Watitu, Sheila West, Ye Win, Geordie Woods, Aya Yajima, Georges Yaya, Alem Zecarias, Solomon Zewengiel, Akoi Zoumanigui, Pamela J Hooper, Tom Millar, Lisa Rotondo, Anthony W Solomon
PURPOSE: Population-based prevalence surveys are essential for decision-making on interventions to achieve trachoma elimination as a public health problem. This paper outlines the methodologies of Tropical Data, which supports work to undertake those surveys. METHODS: Tropical Data is a consortium of partners that supports health ministries worldwide to conduct globally standardised prevalence surveys that conform to World Health Organization recommendations. Founding principles are health ministry ownership, partnership and collaboration, and quality assurance and quality control at every step of the survey process...
December 2023: Ophthalmic Epidemiology
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