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https://www.readbyqxmd.com/read/28504931/robust-real-time-musculoskeletal-modeling-driven-by-electromyograms
#1
Guillaume Durandau, Dario Farina, Massimo Sartori
OBJECTIVE: Current clinical biomechanics involves lengthy data acquisition and time-consuming offline analyses and current biomechanical models cannot be used for real-time control in man-machine interfaces. We developed a method that enables online analysis of neuromusculoskeletal function in vivo in the intact human. METHODS: We used electromyography (EMG)-driven musculoskeletal modeling to simulate all transformations from muscle excitation onset (EMGs) to mechanical moment production around multiple lower-limb degrees of freedom (DOFs)...
May 12, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28483446/molecular-recognition-of-the-environment-and-mechanisms-of-the-origin-of-species-in-quantum-like-modeling-of-evolution
#2
REVIEW
Alexey V Melkikh, Andrei Khrennikov
A review of the mechanisms of speciation is performed. The mechanisms of the evolution of species, taking into account the feedback of the state of the environment and mechanisms of the emergence of complexity, are considered. It is shown that these mechanisms, at the molecular level, cannot work steadily in terms of classical mechanics. Quantum mechanisms of changes in the genome, based on the long-range interaction potential between biologically important molecules, are proposed as one of possible explanation...
May 5, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28456879/anti-inflammatory-effect-as-a-mechanism-of-effectiveness-underlying-the-clinical-benefits-of-pelotherapy-in-osteoarthritis-patients-regulation-of-the-altered-inflammatory-and-stress-feedback-response
#3
E Ortega, I Gálvez, M D Hinchado, J Guerrero, L Martín-Cordero, S Torres-Piles
The purpose of the present investigation was to evaluate whether an anti-inflammatory effect together with an improvement of the regulation of the interaction between the inflammatory and stress responses underlies the clinical benefits of pelotherapy in osteoarthritis (OA) patients. This study evaluated the effects of a 10-day cycle of pelotherapy at the spa centre 'El Raposo' (Spain) in a group of 21 OA patients diagnosed with primary knee OA. Clinical assessments included pain intensity using a visual analog scale; pain, stiffness and physical function using the Western Ontario and McMaster Universities Arthritis Index; and health-related quality of life using the EuroQol-5D questionnaire...
April 29, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28322172/immune-neuroendocrine-dysregulation-in-patients-with-osteoarthritis-a-revision-and-a-pilot-study
#4
Isabel Gálvez, Silvia Torres-Piles, María Dolores Hinchado, Alberto Álvarez-Barrientos, Pilar Torralbo-Jiménez, Jorge Guerrero, Leticia Martín-Cordero, Eduardo Ortega
BACKGROUND: Although osteoarthritis has predominantly been considered a non-inflammatory degenerative arthropathy, there is growing evidence that various inflammatory and immunological processes might contribute to the onset, progression, and burden of the disease. OBJECTIVE: The purpose of the present investigation was to study the systemic inflammatory and stress responses and the innate response mediated by neutrophils in OA patients. METHOD: A group of patients diagnosed with primary OA according to the American College of Rheumatology criteria and a control group of age-matched healthy volunteers were enrolled in the study...
March 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28228081/the-neurobiology-and-psychiatric-perspective-of-vaginismus-linking-the-pharmacological-and-psycho-social-interventions
#5
Zuri Shahidii Kadir, Hatta Sidi, Jaya Kumar, Srijit Das, Marhani Midin, Najwa Baharuddin
Vaginismus is an involuntary muscle contraction of the outer third of vaginal barrel causing sexual penetration almost impossible. It is generally classified under sexual pain disorder (SPD). In Diagnostic and Statistical Manual, 5th edition, it is classified under the new rubric of Genito-Pelvic Pain/Sexual Penetration Disorder. This fear-avoidance condition poses an ongoing significant challenge to the medical and health professionals due to the very demanding needs in health care despite its unpredictable prognosis...
February 22, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28208731/in-vivo-imaging-of-local-gene-expression-induced-by-magnetic-hyperthermia
#6
Olivier Sandre, Coralie Genevois, Eneko Garaio, Laurent Adumeau, Stéphane Mornet, Franck Couillaud
The present work aims to demonstrate that colloidal dispersions of magnetic iron oxide nanoparticles stabilized with dextran macromolecules placed in an alternating magnetic field can not only produce heat, but also that these particles could be used in vivo for local and noninvasive deposition of a thermal dose sufficient to trigger thermo-induced gene expression. Iron oxide nanoparticles were first characterized in vitro on a bio-inspired setup, and then they were assayed in vivo using a transgenic mouse strain expressing the luciferase reporter gene under transcriptional control of a thermosensitive promoter...
February 8, 2017: Genes
https://www.readbyqxmd.com/read/28195187/sensory-augmentation-integration-of-an-auditory-compass-signal-into-human-perception-of-space
#7
Frank Schumann, J Kevin O'Regan
Bio-mimetic approaches to restoring sensory function show great promise in that they rapidly produce perceptual experience, but have the disadvantage of being invasive. In contrast, sensory substitution approaches are non-invasive, but may lead to cognitive rather than perceptual experience. Here we introduce a new non-invasive approach that leads to fast and truly perceptual experience like bio-mimetic techniques. Instead of building on existing circuits at the neural level as done in bio-mimetics, we piggy-back on sensorimotor contingencies at the stimulus level...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28178519/structural-inheritance-of-the-actin-cytoskeletal-organization-determines-the-body-axis-in-regenerating-hydra
#8
Anton Livshits, Lital Shani-Zerbib, Yonit Maroudas-Sacks, Erez Braun, Kinneret Keren
Understanding how mechanics complement bio-signaling in defining patterns during morphogenesis is an outstanding challenge. Here, we utilize the multicellular polyp Hydra to investigate the role of the actomyosin cytoskeleton in morphogenesis. We find that the supra-cellular actin fiber organization is inherited from the parent Hydra and determines the body axis in regenerating tissue segments. This form of structural inheritance is non-trivial because of the tissue folding and dynamic actin reorganization involved...
February 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/28176677/predicting-burst-pressure-of-radiofrequency-induced-colorectal-anastomosis-by-bio-impedance-measurement
#9
Lingxi Zhao, Yu Zhou, Chengli Song, Zhigang Wang, Alfred Cuschieri
The present study investigates the relationship between bio-impedance and burst pressure of colorectal anastomosis created by radiofrequency (RF)-induced tissue fusion. Colorectal anastomosis were created with ex vivo porcine colorectal segments, during which 5 levels of compression pressure were applied by a custom-made bipolar prototype, with 5 replicate experiments at each compression pressure. Instant anastomotic tensile strength was assessed by burst pressure. Bio-impedance of fused tissue was measured by Impedance Analyzer across frequency that 100 Hz to 3 MHz...
March 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28127401/synthetic-redesign-of-escherichia-coli-for-cadaverine-production-from-galactose
#10
Dong Hun Kwak, Hyun Gyu Lim, Jina Yang, Sang Woo Seo, Gyoo Yeol Jung
BACKGROUND: With increasing concerns over the environment, biological production of cadaverine has been suggested as an alternative route to replace polyamides generated from the petroleum-based process. For an ideal bioprocess, cadaverine should be produced with high yield and productivity from various sugars abundant in biomass. However, most microorganisms are not able to efficiently metabolize other biomass-derived sugars as fast as glucose. This results in reduced growth rate and low carbon flux toward the production of desired bio-chemicals...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28003193/fermentative-production-of-cysteine-by-pantoea-ananatis
#11
Kazuhiro Takumi, Mikhail Kharisovich Ziyatdinov, Viktor Samsonov, Gen Nonaka
Cysteine is a commercially important amino acid; however, it lacks an efficient fermentative production method. Due to its cytotoxicity, intracellular cysteine levels are stringently controlled via several regulatory modes. Managing its toxic effects as well as understanding and deregulating the complexities of regulation are crucial for establishing the fermentative production of cysteine. The regulatory modes include feedback inhibition of key metabolic enzymes, degradation, efflux pumps, and the transcriptional regulation of biosynthetic genes by a master cysteine regulator, CysB...
March 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27906686/investigation-of-collective-behaviour-and-electrocommunication-in-the-weakly-electric-fish-mormyrus-rume-through-a-biomimetic-robotic-dummy-fish
#12
Elisa Donati, Martin Worm, Stefano Mintchev, Marleen van der Wiel, Giovanni Benelli, Gerhard von der Emde, Cesare Stefanini
A robotic fish has been developed to create a mixed bio-hybrid system made up of weakly electric fish and a mobile dummy fish. Weakly electric fish are capable of interacting with each other via sequences of self-generated electric signals during electrocommunication. Here we present the design of an artificial dummy fish, which is subsequently tested in behavioural experiments. The robot consists of two parts: a flexible tail that can move at different frequencies and amplitudes, performing a carangiform oscillation, and a rigid head containing the motor for the tail oscillation...
December 1, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27882895/planar-maneuvering-control-of-underwater-snake-robots-using-virtual-holonomic-constraints
#13
Anna M Kohl, Eleni Kelasidi, Alireza Mohammadi, Manfredi Maggiore, Kristin Y Pettersen
This paper investigates the problem of planar maneuvering control for bio-inspired underwater snake robots that are exposed to unknown ocean currents. The control objective is to make a neutrally buoyant snake robot which is subject to hydrodynamic forces and ocean currents converge to a desired planar path and traverse the path with a desired velocity. The proposed feedback control strategy enforces virtual constraints which encode biologically inspired gaits on the snake robot configuration. The virtual constraints, parametrized by states of dynamic compensators, are used to regulate the orientation and forward speed of the snake robot...
November 24, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27871379/decolourisation-of-acid-orange-7-in-a-microbial-fuel-cell-with-a-laccase-based-biocathode-influence-of-mitigating-ph-changes-in-the-cathode-chamber
#14
Priyadharshini Mani, Taj Keshavarz, T S Chandra, Godfrey Kyazze
Biocathodes may be a suitable replacement of platinum in microbial fuel cells (MFCs) if the cost of MFCs is to be reduced. However, the use of enzymes as bio-cathodes is fraught with loss of activity as time progresses. A possible cause of this loss in activity might be pH increase in the cathode as pH gradients in MFCs are well known. This pH increase is however, accompanied by simultaneous increase in salinity; therefore salinity may be a confounding variable. This study investigated various ways of mitigating pH changes in the cathode of MFCs and their effect on laccase activity and decolourisation of a model azo dye Acid orange 7 in the anode chamber...
January 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27710870/individuals-with-high-obsessive-compulsive-tendencies-or-undermined-confidence-rely-more-on-external-proxies-to-access-their-internal-states
#15
Zhongming Zhang, Mengyun Wang, Xiaocui Miao, Yijuan Li, Glenn Hitchman, Zhen Yuan
BACKGROUND AND OBJECTIVES: The Seeking Proxies for Internal States (SPIS) hypothesis predicts that obsessive-compulsive disorder (OCD) is associated with a deficit in subjective convictions, which may lead to a reliance on external substitutes for the perceptions of an individual's internal states. Two well-designed studies were performed for the present work that adopted a false bio-feedback procedure in a muscle tension task to examine the SPIS hypothesis. METHODS: The false bio-feedback paradigm was used to investigate our hypothesis...
September 28, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27616320/interactive-bio-feedback-therapy-using-hybrid-assistive-limbs-for-motor-recovery-after-stroke-current-practice-and-future-perspectives
#16
Takashi Morishita, Tooru Inoue
Interactive bio-feedback (iBF) was initially developed for the rehabilitation of motor function in patients with neurological disorders, and subsequently yielded the development of the hybrid assistive limb (HAL). Here, we provide a review of the theory underlying HAL treatment as well as our clinical experience and recommendations for future clinical studies using HAL in acute stroke patients. We performed a PubMed-based literature search, a retrospective data review of our acute stroke case series, and included a sample case report of our findings...
October 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27591579/sensitivity-of-soil-carbon-fractions-and-their-specific-stabilization-mechanisms-to-extreme-soil-warming-in-a-subarctic-grassland
#17
Christopher Poeplau, Thomas Kätterer, Niki I W Leblans, Bjarni D Sigurdsson
Terrestrial carbon cycle feedbacks to global warming are major uncertainties in climate models. For in-depth understanding of changes in soil organic carbon (SOC) after soil warming, long-term responses of SOC stabilization mechanisms such as aggregation, organo-mineral interactions and chemical recalcitrance need to be addressed. This study investigated the effect of 6 years of geothermal soil warming on different SOC fractions in an unmanaged grassland in Iceland. Along an extreme warming gradient of +0 to ~+40 °C, we isolated five fractions of SOC that varied conceptually in turnover rate from active to passive in the following order: particulate organic matter (POM), dissolved organic carbon (DOC), SOC in sand and stable aggregates (SA), SOC in silt and clay (SC-rSOC) and resistant SOC (rSOC)...
September 3, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27549154/tailored-parameter-optimization-methods-for-ordinary-differential-equation-models-with-steady-state-constraints
#18
Anna Fiedler, Sebastian Raeth, Fabian J Theis, Angelika Hausser, Jan Hasenauer
BACKGROUND: Ordinary differential equation (ODE) models are widely used to describe (bio-)chemical and biological processes. To enhance the predictive power of these models, their unknown parameters are estimated from experimental data. These experimental data are mostly collected in perturbation experiments, in which the processes are pushed out of steady state by applying a stimulus. The information that the initial condition is a steady state of the unperturbed process provides valuable information, as it restricts the dynamics of the process and thereby the parameters...
2016: BMC Systems Biology
https://www.readbyqxmd.com/read/27511743/vhldb-a-database-of-von-hippel-lindau-protein-interactors-and-mutations
#19
Francesco Tabaro, Giovanni Minervini, Faiza Sundus, Federica Quaglia, Emanuela Leonardi, Damiano Piovesan, Silvio C E Tosatto
Mutations in von Hippel-Lindau tumor suppressor protein (pVHL) predispose to develop tumors affecting specific target organs, such as the retina, epididymis, adrenal glands, pancreas and kidneys. Currently, more than 400 pVHL interacting proteins are either described in the literature or predicted in public databases. This data is scattered among several different sources, slowing down the comprehension of pVHL's biological role. Here we present VHLdb, a novel database collecting available interaction and mutation data on pVHL to provide novel integrated annotations...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27454551/an-implementation-focused-bio-algorithmic-workflow-for-synthetic-biology
#20
Angel Goñi-Moreno, Marta Carcajona, Juhyun Kim, Esteban Martínez-García, Martyn Amos, Víctor de Lorenzo
As synthetic biology moves away from trial and error and embraces more formal processes, workflows have emerged that cover the roadmap from conceptualization of a genetic device to its construction and measurement. This latter aspect (i.e., characterization and measurement of synthetic genetic constructs) has received relatively little attention to date, but it is crucial for their outcome. An end-to-end use case for engineering a simple synthetic device is presented, which is supported by information standards and computational methods and focuses on such characterization/measurement...
October 21, 2016: ACS Synthetic Biology
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