keyword
https://read.qxmd.com/read/38476578/medical-costs-associated-with-high-moderate-low-likelihood-of-adult-growth-hormone-deficiency-a-healthcare-claims-database-analysis
#21
JOURNAL ARTICLE
Kevin C J Yuen, Lewis S Blevins, David R Clemmons, Mads Faurby, Andrew R Hoffman, Nicky Kelepouris, Janice M Kerr, Jens Magelund Tarp, Maria Fleseriu
PURPOSE: Adult growth hormone deficiency (AGHD) is often underdiagnosed and undertreated, leading to costly comorbidities. Previously, we developed an algorithm to identify individuals in a commercially insured US population with high, moderate, or low likelihood of having AGHD. Here, we estimate and compare direct medical costs by likelihood level. PATIENTS AND METHODS: Retrospective, observational analysis using the Truven Health MarketScan database to analyze direct medical costs relating to inpatient and outpatient claims, outpatient prescription claims, medication usage, clinical utilization records, and healthcare expenditures...
2024: ClinicoEconomics and Outcomes Research: CEOR
https://read.qxmd.com/read/38474709/dietary-sodium-restriction-and-frailty-among-middle-aged-and-older-adults-an-8-year-longitudinal-study
#22
JOURNAL ARTICLE
Yu-Chun Lin, Huang-Ting Yan
Frailty is a common geriatric syndrome. However, there is little information about the relationship between dietary sodium restriction (DSR) and frailty in later life. This study aimed to elucidate the relationship between DSR and frailty in middle-aged and older adults. The 8-year follow-up data from the Taiwan Longitudinal Study on Aging, including 5131 individuals aged ≥50 years, were analyzed using random-effects panel logit models. DSR was evaluated by assessing whether the participants were told by a physician to reduce or avoid sodium intake from food...
February 20, 2024: Nutrients
https://read.qxmd.com/read/38468667/traumatic-penetrating-head-injury-by-crossbow-projectiles-a-case-report-and-literature-review
#23
Moath Abdullah Khayat, Hassan Khayat, Mohamed Rashed Alhantoobi, Majid Aljoghaiman, Doron D Sommer, Almunder Algird, Daipayan Guha
BACKGROUND: Low-energy penetrating head injuries caused by arrows are relatively uncommon. The objective of this report is to describe a case presentation and management of self-inflicted intracranial injury using a crossbow and to provide a relevant literature review. CASE REPORT: A 31-year-old man with a previous psychiatric history sustained a self-inflicted injury using a crossbow that he bought from a department store. The patient arrived neurologically intact at the hospital, fully awake and oriented...
2024: Surgical Neurology International
https://read.qxmd.com/read/38465952/biomarker-assessment-of-a-high-risk-data-driven-pediatric-sepsis-phenotype-characterized-by-persistent-hypoxemia-encephalopathy-and-shock
#24
JOURNAL ARTICLE
Mihir R Atreya, Tellen D Bennett, Alon Geva, E Vincent S Faustino, Colin M Rogerson, Riad Lutfi, Natalie Z Cvijanovich, Michael T Bigham, Jeffrey Nowak, Adam J Schwarz, Torrey Baines, Bereketeab Haileselassie, Neal J Thomas, Yuan Luo, L Nelson Sanchez-Pinto
OBJECTIVES: Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. We sought to the determine reproducibility of the data-driven "persistent hypoxemia, encephalopathy, and shock" (PHES) phenotype and determine its association with inflammatory and endothelial biomarkers, as well as biomarker-based pediatric risk strata. DESIGN: We retrained and validated a random forest classifier using organ dysfunction subscores in the 2012-2018 electronic health record (EHR) dataset used to derive the PHES phenotype...
March 11, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38464555/heart-failure-nurses-within-the-primary-care-setting
#25
REVIEW
Loreena Hill, Anne McNulty, James McMahon, Gary Mitchell, Cathy Farrell, Izabella Uchmanowicz, Teresa Castiello
Cardiology services within primary care often focus on disease prevention, early identification of illness and prompt referral for diagnosis and specialist treatment. Due to advances in pharmaceuticals, implantable cardiac devices and surgical interventions, individuals with heart failure are living longer, which can place a significant strain on global healthcare resources. Heart failure nurses in a primary care setting offer a wealth of clinical knowledge and expertise across all phases of the heart failure trajectory and are able to support patients, family members and other community services, including general practitioners...
2024: Cardiac Failure Review
https://read.qxmd.com/read/38464257/kidney-outcomes-and-trajectories-of-tubular-injury-and-function-in-critically-ill-persons-with-and-without-coronavirus-2019
#26
Michael L Granda, Frances Tian, Leila R Zelnick, Pavan K Bhatraju, Mark M Wurfel, Andrew Hoofnagle, Eric Morrell, Bryan Kestenbaum
Background Coronavirus disease-2019 (COVID-19) may injure the kidney tubules via activation of inflammatory host responses and/or direct viral infiltration. Most studies of kidney injury in COVID-19 lacked contemporaneous controls or measured kidney biomarkers at a single time point. To better understand mechanisms of AKI in COVID-19, we compared kidney outcomes and trajectories of tubular injury, viability, and function in prospectively enrolled critically ill adults with and without COVID-19. Methods The COVID-19 Host Response and Outcomes (CHROME) study prospectively enrolled patients admitted to intensive care units in Washington state with symptoms of lower respiratory tract infection, determining COVID-19 status by nucleic acid amplification on arrival...
February 28, 2024: Research Square
https://read.qxmd.com/read/38463457/severe-refractory-obsessive-compulsive-disorder-and-depression-should-we-consider-stereotactic-neurosurgery
#27
JOURNAL ARTICLE
Ludvic Zrinzo
Functional neurosurgery involves modulation of activity within neural circuits that drive pathological activity. Neurologists and neurosurgeons have worked closely together, advancing the field for over a century, such that neurosurgical procedures for movement disorders are now accepted as "standard of care", benefiting hundreds of thousands of patients. As with movement disorders, some neuropsychiatric illnesses, including obsessive compulsive disorder and depression, can be framed as disorders of neural networks...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38458308/children-s-early-signs-and-developmental-trajectories-of-psychotic-like-experiences
#28
JOURNAL ARTICLE
Luxia Jia, Ziqian Wei, Juan Wang, Xuan Zhang, Huagen Wang, Runsen Chen, Xiaoqian Zhang
INTRODUCTION: Children who experience persistent psychotic-like experiences (PLEs) are at a higher risk of developing psychotic disorder later in life. The developmental trajectories of PLEs are influenced by various factors. Therefore, it is important to identify early characteristics that can distinguish and predict between different developmental trajectories of PLEs. METHODS: Using PLEs scores from the Adolescent Brain Cognitive Development (ABCD) data across three waves, we categorized participants into five distinct PLEs trajectories groups: persistent group (n = 47), remitting group (n = 185), increasing group (n = 117), remittent group (n = 21), and no PLEs group (n = 4,476)...
March 6, 2024: Brain Research
https://read.qxmd.com/read/38456852/palliative-care-across-the-spectrum%C3%A2-of%C3%A2-heart%C3%A2-failure
#29
REVIEW
Laura P Gelfman, Moritz Blum, Modele O Ogunniyi, Colleen K McIlvennan, Dio Kavalieratos, Larry A Allen
Persons with heart failure (HF) often suffer from poor symptom control, decreased quality of life, and poor communication with their health care providers. These needs are particularly acute in advanced HF, a leading cause of death in the United States. Palliative care, when offered alongside HF disease management, offers improved symptom control, quality of life, communication, and caregiver satisfaction as well as reduced caregiver anxiety. The dynamic nature of the clinical trajectory of HF presents distinct symptom patterns, changing functional status, and uncertainty, which requires an adaptive, dynamic model of palliative care delivery...
February 27, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38454435/prenatal-polycyclic-aromatic-hydrocarbon-exposure-and-asthma-at-age-8-9%C3%A2-years-in-a-multi-site-longitudinal-study
#30
JOURNAL ARTICLE
Allison R Sherris, Christine T Loftus, Adam A Szpiro, Logan C Dearborn, Marnie F Hazlehurst, Kecia N Carroll, Paul E Moore, Margaret A Adgent, Emily S Barrett, Nicole R Bush, Drew B Day, Kurunthachalam Kannan, Kaja Z LeWinn, Ruby H N Nguyen, Yu Ni, Anne M Riederer, Morgan Robinson, Sheela Sathyanarayana, Qi Zhao, Catherine J Karr
BACKGROUND AND AIM: Studies suggest prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) may influence wheezing or asthma in preschool-aged children. However, the impact of prenatal PAH exposure on asthma and wheeze in middle childhood remain unclear. We investigated these associations in socio-demographically diverse participants from the ECHO PATHWAYS multi-cohort consortium. METHODS: We included 1,081 birth parent-child dyads across five U.S. cities...
March 8, 2024: Environmental Health
https://read.qxmd.com/read/38454420/development-of-the-parental-experience-with-care-for-children-with-serious-illnesses-precious-quality-of-care-measure
#31
JOURNAL ARTICLE
Felicia Jia Ler Ang, Mihir Gandhi, Truls Ostbye, Chetna Malhotra, Rahul Malhotra, Poh Heng Chong, Zubair Amin, Cristelle Chu-Tian Chow, Teresa Shu Zhen Tan, Komal Tewani, Eric Andrew Finkelstein
BACKGROUND: Parent-reported experience measures are part of pediatric Quality of Care (QoC) assessments. However, existing measures were not developed for use across multiple healthcare settings or throughout the illness trajectory of seriously ill children. Formative work involving in-depth interviews with parents of children with serious illnesses generated 66 draft items describing key QoC processes. Our present aim is to develop a comprehensive parent-reported experience measure of QoC for children with serious illnesses and evaluate its content validity and feasibility...
March 8, 2024: BMC Palliative Care
https://read.qxmd.com/read/38450628/-chat-based-cancer-counseling-in-switzerland-a-reflexive-thematic-analysis-of-chat-protocols-focused-on-cancer-survivors-needs
#32
JOURNAL ARTICLE
Jörg Haslbeck, Flurina Casanova, Diana Cascais, Sandra Staudacher
Chat-based cancer counseling in Switzerland: A reflexive thematic analysis of chat protocols focused on cancer survivors' needs Abstract: Background: The number of people diagnosed with cancer and continue to live as cancer survivors is growing. Together with their relatives, they have information and counseling needs during the illness trajectory. With Cancerline, the Swiss Cancer League offers a chat-based counseling service for cancer survivors. Research question/objective: For the first time, the qualitative study investigated which needs cancer survivors express in Cancerline to gain insights for the further development and quality assurance of chat-based cancer counseling...
March 7, 2024: Pflege
https://read.qxmd.com/read/38449917/burnout-compassion-fatigue-and-the-long-haul-of-caring-for-long-covid
#33
JOURNAL ARTICLE
Christian B Ramers, John D Scott, Bruce B Struminger
The current landscape of clinician burnout is prompting the need for our health care system to revise its approach toward complex conditions such as long coronavirus disease (COVID), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and other postinfectious fatiguing illnesses (PIFIs). We discuss our efforts here at Family Health Center of San Diego (FHCSD) to help share insight and glean perspective from clinicians who have participated in our Centers for Disease Control and Prevention (CDC)-funded 3-year continuing professional development initiative...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38449327/glucocorticoid-effects-on-the-brain-from-adaptive-developmental-plasticity-to-allostatic-overload
#34
REVIEW
Helen Eachus, Soojin Ryu
Exposure to stress during early life may alter the developmental trajectory of an animal by a mechanism known as adaptive plasticity. For example, to enhance reproductive success in an adverse environment, it is known that animals accelerate their growth during development. However, these short-term fitness benefits are often associated with reduced longevity, a phenomenon known as the growth rate-lifespan trade-off. In humans, early life stress exposure compromises health later in life and increases disease susceptibility...
March 7, 2024: Journal of Experimental Biology
https://read.qxmd.com/read/38448073/scoping-review-protocol-of-post-traumatic-growth-ptg-in-korean-cancer-survivors
#35
JOURNAL ARTICLE
Yu-Jin Park, Kyoung Suk Lee
INTRODUCTION: Cancer, a life-threatening chronic disease, is the leading cause of death in Korea, accounting for 27% of all deaths in 2020. Due to advancements in medical technology and early detection of cancer in Korea, the 5-year relative survival rate reached 70.7% (2015-2019), highlighting remarkable progress over the past decades. Although cancer has been seen as a traumatic event, cancer survivors also go through a subjective process of self-maturation, which is called post-traumatic growth (PTG)...
March 5, 2024: BMJ Open
https://read.qxmd.com/read/38447041/high-symptom-burden-predicts-poorer-quality-of-life-among-children-and-adolescents-receiving-hematopoietic-stem-cell-transplantation-or-chimeric-antigen-receptor-t-cell-therapy
#36
JOURNAL ARTICLE
Kathleen E Montgomery, Jennifer L Raybin, Kimberly Powers, Melody Hellsten, Paula Murray, Jessica Ward
BACKGROUND: Children with cancer and other serious illnesses experience symptom burden during hematopoietic stem cell transplantation and chimeric antigen receptor T-cell therapy, yet limited research has characterized how these symptoms interact with overall quality of life over time. OBJECTIVE: The aim of this study was to examine the longitudinal relationship between symptoms and quality of life in children receiving hematopoietic stem cell transplantation or chimeric antigen receptor T-cell therapy...
March 6, 2024: Cancer Nursing
https://read.qxmd.com/read/38445771/an-insight-into-healthcare-professionals-perspectives-on-discussing-implantable-cardioverter-defibrillator-deactivation
#37
JOURNAL ARTICLE
Loreena Hill, Lorna Cassidy, Lana Dixon, Donna Fitzsimons, Ingela Thylen, Tiny Jaarsma
BACKGROUND: International studies have examined patients' views concerning the discussion of deactivating an implantable cardioverter defibrillator (ICD). Findings reported that many patients were either not informed about the subject or were informed late in their illness trajectory. AIM: To explore healthcare professionals' perspectives on discussing ICD deactivation and identify priorities for clinical practice and future research. METHODS: Eleven interviews were conducted, involving heart failure nurses, physicians, and an allied professional...
March 6, 2024: European Journal of Cardiovascular Nursing
https://read.qxmd.com/read/38431874/-being-a-patient-in-the-intensive-care-unit-a-narrative-approach-to-understanding-patients-experiences-of-being-awake-and-on-mechanical-ventilation
#38
JOURNAL ARTICLE
Marte-Marie Wallander Karlsen, Lena Günterberg Heyn, Kristin Heggdal
PURPOSE: Intensive care patients often struggle to communicate due to the technical equipment used for mechanical ventilation and their critical illness. The aim of the study was to achieve a deeper understanding of how mechanically ventilated intensive care patients construct meaning in the unpredictable trajectory of critical illness. METHODS: The study was a part of a larger study in which ten patients were video recorded while being in the intensive care. Five patients engaged in interviews about their experiences from the intensive care stay after being discharged and were offered the possibility to see themselves in the video recordings...
December 2024: International Journal of Qualitative Studies on Health and Well-being
https://read.qxmd.com/read/38430164/examining-the-impact-of-phased-nursing-within-the-chronic-disease-trajectory-model-on-glioma-patient-outcomes
#39
JOURNAL ARTICLE
Changwei Shao
BACKGROUND: Glioma ‎(GL)‎, a primary brain tumor, presents significant challenges in patient care due to its complex disease trajectory and psychological impact. Phased nursing interventions, grounded in the Chronic Illness Trajectory Model (CITM), offer a holistic approach to addressing these multifaceted needs. OBJECTIVE: The objective of this study was to assess the impact of phased nursing within the CITM on the psychological well-being, quality of life, and cancer-related fatigue (CRF) of glioma patients...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38428972/illness-trajectories-of-incurable-solid-cancers
#40
JOURNAL ARTICLE
Eric C T Geijteman, Evelien J M Kuip, Jannie Oskam, Diana Lees, Eduardo Bruera
No abstract text is available yet for this article.
March 1, 2024: BMJ: British Medical Journal
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