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Trajectory of illness

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https://www.readbyqxmd.com/read/29222318/assessing-thrombocytopenia-in-the-intensive-care-unit-the-past-present-and-future
#1
REVIEW
Ryan Zarychanski, Donald S Houston
Thrombocytopenia is common among patients admitted to the intensive care unit (ICU). Multiple pathophysiological mechanisms may contribute, including thrombin-mediated platelet activation, dilution, hemophagocytosis, extracellular histones, ADAMTS13 deficiency, and complement activation. From the clinical perspective, the development of thrombocytopenia in the ICU usually indicates serious organ system derangement and physiologic decompensation rather than a primary hematologic disorder. Thrombocytopenia is associated with bleeding, transfusion, and adverse clinical outcomes including death, though few deaths are directly attributable to bleeding...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29207548/the-role-of-omega-3-fatty-acids-in-developmental-psychopathology-a-systematic-review-on-early-psychosis-autism-and-adhd
#2
REVIEW
Carlo Agostoni, Maria Nobile, Valentina Ciappolino, Giuseppe Delvecchio, Alessandra Tesei, Stefano Turolo, Alessandro Crippa, Alessandra Mazzocchi, Carlo A Altamura, Paolo Brambilla
In this systematic review, we will consider and debate studies that have explored the effects of ω-3 polyunsaturated fatty acids (PUFAs) in three major, and somehow related, developmental psychiatric disorders: Autism, Attention Deficit and Hyperactivity disorder and Psychosis. The impact of ω-3 PUFAs on clinical symptoms and, if possible, brain trajectory in children and adolescents suffering from these illnesses will be reviewed and discussed, considering the biological plausibility of the effects of omega-3 fatty acids, together with their potential perspectives in the field...
December 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29204592/subtyping-patients-with-myalgic-encephalomyelitis-me-and-chronic-fatigue-syndrome-cfs-by-course-of-illness
#3
Jamie Stoothoff, Kristen Gleason, Stephanie McManimen, Taylor Thorpe, Leonard A Jason
Past research has subtyped patients with Myalgic Encephalolyelitis (ME) and Chronic Fatigue Syndrome (CFS) according to factors related to illness onset, illness duration, and age. However, no classification system fully accounts for the wide range of symptom severity, functional disability, progression, and prognosis seen among patients. This study examined whether illness trajectories among individuals with CFS were predictive of different levels of symptomology, functional disability, and energy expenditure...
2017: Journal of biosensors, biomarkers and diagnostics
https://www.readbyqxmd.com/read/29189353/pediatric-palliative-oncology-the-state-of-the-science-and-art-of-caring-for-children-with-cancer
#4
Jennifer M Snaman, Erica C Kaye, Justin N Baker, Joanne Wolfe
PURPOSE OF REVIEW: Pediatric palliative oncology (PPO) is an emerging field that integrates the principles of palliative care early into the illness trajectory of children with cancer. PPO providers work with interdisciplinary clinicians to provide optimal medical and psychosocial care to children with cancer and their families. Ongoing advances in the field of pediatric oncology, including new treatment options for progressive cancers, necessitate the early integration of palliative care tenets including holistic care, high-quality communication, and assessment and management of refractory symptoms...
November 17, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29178408/spousal-recollections-of-early-signs-of-primary-progressive-aphasia
#5
Margaret Pozzebon, Jacinta Douglas, David Ames
BACKGROUND: Although primary progressive aphasia (PPA) is characterized by progressive loss of language and communication skills, knowledge about the earliest emerging signs announcing the onset of this condition is limited. AIMS: To explore spousal recollections regarding the earliest signs of PPA and to compare the nature of the earliest perceived symptoms across the three PPA variants. METHODS & PROCEDURES: In-depth interviews focusing on the earliest signs of illness onset were conducted with 13 spouses whose partners were diagnosed with PPA...
November 26, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29177389/-between-the-acclimatization-to-high-altitude-the-medical-anthropology-and-the-civilizing-utopia-mapping-of-the-evolution-of-thought-of-carlos-monge-medrano-on-the-health-illness-process-of-andean-populations
#6
Juan P Murillo
The main objective of this study is to describe how the ideas of Carlos Monge respect to high altitude sickness developed and how these were being deployed in the framework of the discussions on the living conditions of indigenous populations in the period 1928-1963. I postulate that the form how the Monge's paradigm was proposed, the tensions produced by various alternative movements and the way these contradictions were resolved were central, both for the subsequent development of different scientific disciplines and for their different institutional expressions in Peru...
April 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29168305/the-trajectory-of-anhedonic-and-depressive-symptoms-in-anorexia-nervosa-a-longitudinal-and-cross-sectional-approach
#7
Ilka Boehm, Luisa Flohr, Julius Steding, Larissa Holzapfel, Jochen Seitz, Veit Roessner, Stefan Ehrlich
Anhedonia, the inability to experience pleasure, is associated with depression, schizophrenia and also anorexia nervosa (AN). However, it remains unanswered whether anhedonic symptoms in AN are undernutrition-dependent depressive symptoms or a core feature of AN. Therefore, we aim at investigating the trajectory of anhedonic and depressive symptoms over the course of the disorder. Self-reported symptoms were collected in 35 nonmedicated acutely ill, 33 long-term recovered patients and 62 healthy females. The majority of the acutely ill (n = 24) were followed up after >15% weight restoration (short-term recovery)...
November 23, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29164495/the-clinical-trajectory-of-emerging-bipolar-disorder-among-the-high-risk-offspring-of-bipolar-parents-current-understanding-and-future-considerations
#8
REVIEW
A Duffy, C Vandeleur, N Heffer, M Preisig
BACKGROUND: Relatively little is known about the onset of bipolar disorder, yet the early illness course is already associated with significant morbidity and mortality. Therefore, characterizing the bipolar illness trajectory is key to risk prediction and early intervention advancement. MAIN BODY: In this narrative review, we discuss key findings from prospective longitudinal studies of the high-risk offspring of bipolar parents and related meta-analyses that inform us about the clinical trajectory of emerging bipolar disorder...
November 22, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29164332/individual-trajectories-of-cognitive-performance-in-first-episode-psychosis-a-2-year-follow-up-study
#9
A M Sánchez-Torres, L Moreno-Izco, R Lorente-Omeñaca, B Cabrera, A Lobo, A M González-Pinto, J Merchán-Naranjo, I Corripio, E Vieta, E de la Serna, A Butjosa, F Contreras, S Sarró, G Mezquida, M Ribeiro, M Bernardo, M J Cuesta
Individual changes over time in cognition in patients with psychotic disorders have been studied very little, especially in the case of first episode psychosis (FEP). We aimed to establish whether change in individual trajectories in cognition over 2 years of a sample of 159 FEP patients was reliable and clinically significant, using the reliable change index (RCI) and clinically significant change (CSC) methods. We also studied a sample of 151 matched healthy controls. Patients and controls were assessed with a set of neuropsychological tests, as well as premorbid, clinical and functionality measures...
November 21, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29156921/sexual-healthcare-for-cancer-patients-receiving-palliative-care-a-narrative-review
#10
Katie Wang, Krista Ariello, Matthew Choi, Angela Turner, Bo Angela Wan, Caitlin Yee, Leigha Rowbottom, Rachel Macdonald, Henry Lam, Leah Drost, Edward Chow
Palliative care aims to improve quality of life (QoL) for patients and families and does so by addressing issues not limited to pathology, but other symptoms that may be debilitating to patient experience and QoL. Despite sexual health being an important aspect of life for many patients, it is often omitted in clinical practice. This review summarizes published primary studies to explore the prevalence and importance of incorporating sexual health in the symptom screening and assessments of palliative patients, to identify current interventions that are implemented to address sexual health issues, and identify the barriers that health care professionals (HCPs) and patients may encounter which may prevent sexual health discussions...
November 15, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29149460/the-impact-of-a-prolonged-stay-in-the-icu-on-patients-fundamental-care-needs
#11
Claire Minton, Lesley Batten, Annette Huntington
AIM: To explore patients', families', and health professionals' experiences of a long-stay patient in an intensive care unit. BACKGROUND: The fast-paced technologically driven intensive care unit environment, designed for a short patient stay, supports the provision of complex physiologically-focused care for those with life-threatening illnesses. Long stay patients with pronounced fundamental care needs fall outside predicted patient pathways, and nurses can find caring for these patients challenging...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29145902/-the-20-year-longitudinal-trajectories-of-social-functioning-in-individuals-with-psychotic-disorders
#12
M Oorschot, A K J Fett, E Velthorst
OBJECTIVE: Social impairment is a long-recognized core feature of schizophrenia and is common in other psychotic disorders. Still, to date the long-term trajectories of social impairment in psychotic disorders have rarely been studied systematically. METHODS: Data came from the Suffolk County Mental Health Project, a 20-year prospective study of first-admission patients with psychotic disorders. A never-psychotic comparison group was also assessed. Latent class growth analysis was applied to longitudinal data on social functioning from 485 respondents with schizophrenia spectrum disorders and psychotic mood disorders, and associations of the empirically derived trajectories with premorbid social adjustment, diagnosis, and 20-year outcomes were examined...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29145869/a-mixed-methods-analysis-of-quality-of-life-among-late-life-patients-diagnosed-with-chronic-illnesses
#13
Monica S Frazer, Patrick Mobley
BACKGROUND: Quality of life (QOL) is an important consideration for people living with advancing chronic conditions. Palliative care providers speak about how, despite physical decline in late life, many patients report growth and meaning in other domains. This mixed methods study uses QOL survey responses to explore domain trajectories and interview data to explore how patients with advancing chronic conditions experience distinct QOL domains. METHODS: The study sample includes 156 now-deceased participants who completed the FACIT-Pal quarterly, and 40 (10 now-deceased) participants who discussed QOL in an interview...
November 16, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29129189/a-review-of-the-economic-impact-of-mental-illness
#14
Christopher M Doran, Irina Kinchin
Objective To examine the impact and cost associated with mental illness.Methods A rapid review of the literature from Australia, New Zealand, UK and Canada was undertaken. The review included literature pertaining to the cost-of-illness and impact of mental illness as well as any modelling studies. Included studies were categorised according to impact on education, labour force engagement, earlier retirement or welfare dependency. The well-accepted Drummond 10-point economic appraisal checklist was used to assess the quality of the studies...
November 13, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29126825/artificial-intelligence-in-medical-practice-the-question-to-the-answer
#15
REVIEW
D Douglas Miller, Eric W Brown
Computer science advances and ultra-fast computing speeds find artificial intelligence (AI) broadly benefitting modern society - forecasting weather, recognizing faces, detecting fraud, and deciphering genomics. AI's future role in medical practice remains an unanswered question. Machines (computers) learn to detect patterns not decipherable using biostatistics by processing massive datasets (big data) through layered mathematical models (algorithms). Correcting algorithm mistakes (training) adds to AI predictive model confidence...
November 7, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29117913/two-interventions-for-patients-with-major-depression-and-severe-chronic-obstructive-pulmonary-disease-impact-on-dyspnea-related-disability
#16
George S Alexopoulos, Jo Anne Sirey, Samprit Banerjee, Danielle S Jackson, Dimitris N Kiosses, Cristina Pollari, Richard S Novitch, Amanda Artis, Patrick J Raue
OBJECTIVE: The Personalized Intervention for Depressed Patients with Chronic Obstructive Pulmonary Disease (PID-C) is an intervention aiming to help patients adhere to their rehabilitation and care. This study tested the hypothesis that the Problem-Solving Adherence (PSA) intervention, which integrates problem-solving into adherence enhancement procedures, reduces dyspnea-related disability more than PID-C. Exploratory analyses sought to identify patients with distinct dyspnea-related disability trajectories and to compare their clinical profiles...
October 10, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29114852/a-longitudinal-functional-magnetic-resonance-imaging-study-of-task-control-circuits-and-bulimic-symptoms-over-adolescence
#17
Marilyn Cyr, Martine Fontaine, Mihaela Stefan, Kate Terranova, Daniel C Kopala-Sibley, Evelyn Attia, Rachel Marsh
BACKGROUND: Previous cross-sectional findings from adolescents and adults with Bulimia Nervosa (BN) suggest disturbances in fronto-striatal and cingulo-opercular task control circuits that support self-regulatory processes, including the resolution of cognitive conflict. Herein, we used longitudinal data to examine the developmental trajectories of such disturbances and how the functioning of these circuits relates to changes in BN symptoms over adolescence. METHODS: Thirty-two adolescent females with BN symptoms and 28 healthy control (HC) adolescents participated in the study...
November 8, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29105991/hypertension-and-frailty-in-older-adults
#18
Ivan Aprahamian, Eduardo Sassaki, Marília F Dos Santos, Rafael Izbicki, Rafael C Pulgrossi, Marina M Biella, Ana Camila N Borges, Marcela M Sassaki, Leonardo M Torres, Ícaro S Fernandez, Olívia A Pião, Paula L M Castro, Pedro A Fontenele, Mônica S Yassuda
The association between hypertension and frailty syndrome in older adults remains unclear. There is scarce information about the prevalence of hypertension among frail elderly patients or on its relationship with frailty. Up to one quarter of frail elderly patients present without comorbidity or disability, yet frailty is a leading cause of death. The knowledge and better control of frailty risk factors could influence prognosis. The present study evaluated: (1) the prevalence of hypertension in robust, prefrail, and frail elderly; and (2) factors that might be associated with frailty including hypertension...
November 5, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29105497/the-views-of-adults-with-neurodegenerative-diseases-on-end-of-life-care-a-metasynthesis
#19
Laurence Regan, Nancy J Preston, Fiona J R Eccles, Jane Simpson
OBJECTIVE: Improving end-of-life care for people with neurodegenerative diseases is seen as a clinical priority. In order to do this, it is important to take into account the views expressed by people with these conditions on their experiences of this care. The purpose of this review was to provide a thematic synthesis of the views of adults with neurodegenerative diseases on end-of-life care. METHODS: After a systematic search, 13 articles were included and thematic synthesis was used to collate and interpret findings...
November 6, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29092656/effect-of-anemia-on-mortality-in-mechanically-ventilated-patients-with-chronic-obstructive-pulmonary-disease
#20
Shruti K Gadre, Aravdeep Singh Jhand, Sami Abuqayyas, Xiaofeng Wang, Jorge Guzman, Abhijit Duggal
RATIONALE: The effect of anemia on patients with chronic obstructive pulmonary disease (COPD) requiring invasive mechanical ventilation for acute respiratory failure is unknown. OBJECTIVES: To examine the association between anemia (hemoglobin <12 g/dL) and 90-day and overall mortality in patients with COPD having acute respiratory failure requiring invasive mechanical ventilation. METHODS: Retrospective study of patients admitted to a quaternary referral medical intensive care unit (ICU) between October 2007 and December 2012 with a diagnosis of COPD and requiring invasive mechanical ventilation for acute respiratory failure of any cause...
January 1, 2017: Journal of Intensive Care Medicine
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