Yuliya A Ryabushkina, Kseniya A Ayriyants, Anna A Sapronova, Anastasia S Mutovina, Maria M Kolesnikova, Eva V Mezhlumyan, Natalya P Bondar, Vasiliy V Reshetnikov
Neuroinflammation in the early postnatal period can disturb trajectories of the completion of normal brain development and can lead to mental illnesses, such as depression, anxiety disorders, and personality disorders later in life. In our study, we focused on evaluating short- and long-term effects of neonatal inflammation induced by lipopolysaccharide, poly(I:C), or their combination in female and male C57BL/6 and BTBR mice. We chose the BTBR strain as potentially more susceptible to neonatal inflammation because these mice have behavioral, neuroanatomical, and physiological features of autism spectrum disorders, an abnormal immune response, and several structural aberrations in the brain...
April 11, 2024: Physiology & Behavior