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Cornelia bargmann

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https://www.readbyqxmd.com/read/27893361/regulatory-changes-in-two-chemoreceptor-genes-contribute-to-a-caenorhabditis-elegans-qtl-for-foraging-behavior
#1
Joshua S Greene, May Dobosiewicz, Rebecca A Butcher, Patrick T McGrath, Cornelia I Bargmann
Natural isolates of C. elegans differ in their sensitivity to pheromones that inhibit exploratory behavior. Previous studies identified a QTL for pheromone sensitivity that includes alternative alleles of srx-43, a chemoreceptor that inhibits exploration through its activity in ASI sensory neurons. Here we show that the QTL is multigenic and includes alternative alleles of srx-44, a second chemoreceptor gene that modifies pheromone sensitivity. srx-44 either promotes or inhibits exploration depending on its expression in the ASJ or ADL sensory neurons, respectively...
November 28, 2016: ELife
https://www.readbyqxmd.com/read/27804275/oxytocin-mediated-behavior-in-invertebrates-an-evolutionary-perspective
#2
REVIEW
Meghan A Lockard, Margaret S Ebert, Cornelia I Bargmann
The molecular and functional conservation of oxytocin-related neuropeptides in behavior is striking. In animals separated by at least 600 million years of evolution, from roundworms to humans, oxytocin homologs play critical roles in the modulation of reproductive behavior and other biological functions. Here, we review the roles of oxytocin in invertebrate behavior from an evolutionary perspective. We begin by tracing the evolution of oxytocin through the invertebrate animal lineages, and then describe common themes in invertebrate behaviors that are mediated by oxytocin-related peptides, including reproductive behavior, learning and memory, food arousal, and predator/prey relationships...
November 2, 2016: Developmental Neurobiology
https://www.readbyqxmd.com/read/27799655/balancing-selection-shapes-density-dependent-foraging-behaviour
#3
Joshua S Greene, Maximillian Brown, May Dobosiewicz, Itzel G Ishida, Evan Z Macosko, Xinxing Zhang, Rebecca A Butcher, Devin J Cline, Patrick T McGrath, Cornelia I Bargmann
The optimal foraging strategy in a given environment depends on the number of competing individuals and their behavioural strategies. Little is known about the genes and neural circuits that integrate social information into foraging decisions. Here we show that ascaroside pheromones, small glycolipids that signal population density, suppress exploratory foraging in Caenorhabditis elegans, and that heritable variation in this behaviour generates alternative foraging strategies. We find that natural C. elegans isolates differ in their sensitivity to the potent ascaroside icas#9 (IC-asc-C5)...
October 31, 2016: Nature
https://www.readbyqxmd.com/read/27383131/parallel-encoding-of-sensory-history-and-behavioral-preference-during-caenorhabditis-elegans-olfactory-learning
#4
Christine E Cho, Chantal Brueggemann, Noelle D L'Etoile, Cornelia I Bargmann
Sensory experience modifies behavior through both associative and non-associative learning. In Caenorhabditis elegans, pairing odor with food deprivation results in aversive olfactory learning, and pairing odor with food results in appetitive learning. Aversive learning requires nuclear translocation of the cGMP-dependent protein kinase EGL-4 in AWC olfactory neurons and an insulin signal from AIA interneurons. Here we show that the activity of neurons including AIA is acutely required during aversive, but not appetitive, learning...
2016: ELife
https://www.readbyqxmd.com/read/27231594/multifocus-microscopy-with-precise-color-multi-phase-diffractive-optics-applied-in-functional-neuronal-imaging
#5
Sara Abrahamsson, Rob Ilic, Jan Wisniewski, Brian Mehl, Liya Yu, Lei Chen, Marcelo Davanco, Laura Oudjedi, Jean-Bernard Fiche, Bassam Hajj, Xin Jin, Joan Pulupa, Christine Cho, Mustafa Mir, Mohamed El Beheiry, Xavier Darzacq, Marcelo Nollmann, Maxime Dahan, Carl Wu, Timothée Lionnet, J Alexander Liddle, Cornelia I Bargmann
Multifocus microscopy (MFM) allows high-resolution instantaneous three-dimensional (3D) imaging and has been applied to study biological specimens ranging from single molecules inside cells nuclei to entire embryos. We here describe pattern designs and nanofabrication methods for diffractive optics that optimize the light-efficiency of the central optical component of MFM: the diffractive multifocus grating (MFG). We also implement a "precise color" MFM layout with MFGs tailored to individual fluorophores in separate optical arms...
March 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27011354/sensitive-red-protein-calcium-indicators-for-imaging-neural-activity
#6
Hod Dana, Boaz Mohar, Yi Sun, Sujatha Narayan, Andrew Gordus, Jeremy P Hasseman, Getahun Tsegaye, Graham T Holt, Amy Hu, Deepika Walpita, Ronak Patel, John J Macklin, Cornelia I Bargmann, Misha B Ahrens, Eric R Schreiter, Vivek Jayaraman, Loren L Looger, Karel Svoboda, Douglas S Kim
Genetically encoded calcium indicators (GECIs) allow measurement of activity in large populations of neurons and in small neuronal compartments, over times of milliseconds to months. Although GFP-based GECIs are widely used for in vivo neurophysiology, GECIs with red-shifted excitation and emission spectra have advantages for in vivo imaging because of reduced scattering and absorption in tissue, and a consequent reduction in phototoxicity. However, current red GECIs are inferior to the state-of-the-art GFP-based GCaMP6 indicators for detecting and quantifying neural activity...
2016: ELife
https://www.readbyqxmd.com/read/26871629/distinct-circuits-for-the-formation-and-retrieval-of-an-imprinted-olfactory-memory
#7
Xin Jin, Navin Pokala, Cornelia I Bargmann
Memories formed early in life are particularly stable and influential, representing privileged experiences that shape enduring behaviors. We show that exposing newly hatched C. elegans to pathogenic bacteria results in persistent aversion to those bacterial odors, whereas adult exposure generates only transient aversive memory. Long-lasting imprinted aversion has a critical period in the first larval stage and is specific to the experienced pathogen. Distinct groups of neurons are required during formation (AIB, RIM) and retrieval (AIY, RIA) of the imprinted memory...
February 11, 2016: Cell
https://www.readbyqxmd.com/read/26824391/a-stochastic-neuronal-model-predicts-random-search-behaviors-at-multiple-spatial-scales-in-c-elegans
#8
William M Roberts, Steven B Augustine, Kristy J Lawton, Theodore H Lindsay, Tod R Thiele, Eduardo J Izquierdo, Serge Faumont, Rebecca A Lindsay, Matthew Cale Britton, Navin Pokala, Cornelia I Bargmann, Shawn R Lockery
Random search is a behavioral strategy used by organisms from bacteria to humans to locate food that is randomly distributed and undetectable at a distance. We investigated this behavior in the nematode Caenorhabditis elegans, an organism with a small, well-described nervous system. Here we formulate a mathematical model of random search abstracted from the C. elegans connectome and fit to a large-scale kinematic analysis of C. elegans behavior at submicron resolution. The model predicts behavioral effects of neuronal ablations and genetic perturbations, as well as unexpected aspects of wild type behavior...
January 29, 2016: ELife
https://www.readbyqxmd.com/read/26789243/corrigendum-dissecting-a-circuit-for-olfactory-behaviour-in-caenorhabditis-elegans
#9
Sreekanth H Chalasani, Nikos Chronis, Makoto Tsunozaki, Jesse M Gray, Daniel Ramot, Miriam B Goodman, Cornelia I Bargmann
No abstract text is available yet for this article.
May 5, 2016: Nature
https://www.readbyqxmd.com/read/26365196/a-circuit-for-gradient-climbing-in-c-elegans-chemotaxis
#10
Johannes Larsch, Steven W Flavell, Qiang Liu, Andrew Gordus, Dirk R Albrecht, Cornelia I Bargmann
Animals have a remarkable ability to track dynamic sensory information. For example, the nematode Caenorhabditis elegans can locate a diacetyl odor source across a 100,000-fold concentration range. Here, we relate neuronal properties, circuit implementation, and behavioral strategies underlying this robust navigation. Diacetyl responses in AWA olfactory neurons are concentration and history dependent; AWA integrates over time at low odor concentrations, but as concentrations rise, it desensitizes rapidly through a process requiring cilia transport...
September 22, 2015: Cell Reports
https://www.readbyqxmd.com/read/26197178/how-the-new-neuroscience-will-advance-medicine
#11
Cornelia I Bargmann
No abstract text is available yet for this article.
July 21, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/25837112/multifocus-polarization-microscope-mf-polscope-for-3d-polarization-imaging-of-up-to-25-focal-planes-simultaneously
#12
Sara Abrahamsson, Molly McQuilken, Shalin B Mehta, Amitabh Verma, Johannes Larsch, Rob Ilic, Rainer Heintzmann, Cornelia I Bargmann, Amy S Gladfelter, Rudolf Oldenbourg
We have developed an imaging system for 3D time-lapse polarization microscopy of living biological samples. Polarization imaging reveals the position, alignment and orientation of submicroscopic features in label-free as well as fluorescently labeled specimens. Optical anisotropies are calculated from a series of images where the sample is illuminated by light of different polarization states. Due to the number of images necessary to collect both multiple polarization states and multiple focal planes, 3D polarization imaging is most often prohibitively slow...
March 23, 2015: Optics Express
https://www.readbyqxmd.com/read/25823863/the-brain-initiative-developing-technology-to-catalyse-neuroscience-discovery
#13
REVIEW
Lyric A Jorgenson, William T Newsome, David J Anderson, Cornelia I Bargmann, Emery N Brown, Karl Deisseroth, John P Donoghue, Kathy L Hudson, Geoffrey S F Ling, Peter R MacLeish, Eve Marder, Richard A Normann, Joshua R Sanes, Mark J Schnitzer, Terrence J Sejnowski, David W Tank, Roger Y Tsien, Kamil Ugurbil, John C Wingfield
The evolution of the field of neuroscience has been propelled by the advent of novel technological capabilities, and the pace at which these capabilities are being developed has accelerated dramatically in the past decade. Capitalizing on this momentum, the United States launched the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative to develop and apply new tools and technologies for revolutionizing our understanding of the brain. In this article, we review the scientific vision for this initiative set forth by the National Institutes of Health and discuss its implications for the future of neuroscience research...
May 19, 2015: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/25772698/feedback-from-network-states-generates-variability-in-a-probabilistic-olfactory-circuit
#14
Andrew Gordus, Navin Pokala, Sagi Levy, Steven W Flavell, Cornelia I Bargmann
Variability is a prominent feature of behavior and is an active element of certain behavioral strategies. To understand how neuronal circuits control variability, we examined the propagation of sensory information in a chemotaxis circuit of C. elegans where discrete sensory inputs can drive a probabilistic behavioral response. Olfactory neurons respond to odor stimuli with rapid and reliable changes in activity, but downstream AIB interneurons respond with a probabilistic delay. The interneuron response to odor depends on the collective activity of multiple neurons-AIB, RIM, and AVA-when the odor stimulus arrives...
April 9, 2015: Cell
https://www.readbyqxmd.com/read/25272342/what-the-brain-initiative-means-for-psychiatry
#15
Cornelia I Bargmann, Jeffrey A Lieberman
No abstract text is available yet for this article.
October 2014: American Journal of Psychiatry
https://www.readbyqxmd.com/read/24711071/the-brain-research-through-advancing-innovative-neurotechnologies-brain-initiative-and-neurology
#16
REVIEW
Cornelia I Bargmann, William T Newsome
No abstract text is available yet for this article.
June 2014: JAMA Neurology
https://www.readbyqxmd.com/read/24550306/inducible-and-titratable-silencing-of-caenorhabditis-elegans-neurons-in-vivo-with-histamine-gated-chloride-channels
#17
Navin Pokala, Qiang Liu, Andrew Gordus, Cornelia I Bargmann
Recent progress in neuroscience has been facilitated by tools for neuronal activation and inactivation that are orthogonal to endogenous signaling systems. We describe here a chemical-genetic approach for inducible silencing of Caenorhabditis elegans neurons in intact animals, using the histamine-gated chloride channel HisCl1 from Drosophila and exogenous histamine. Administering histamine to freely moving C. elegans that express HisCl1 transgenes in neurons leads to rapid and potent inhibition of neural activity within minutes, as assessed by behavior, functional calcium imaging, and electrophysiology of neurons expressing HisCl1...
February 18, 2014: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/24440227/temporal-responses-of-c-elegans-chemosensory-neurons-are-preserved-in-behavioral-dynamics
#18
Saul Kato, Yifan Xu, Christine E Cho, L F Abbott, Cornelia I Bargmann
Animals track fluctuating stimuli over multiple timescales during natural olfactory behaviors. Here, we define mechanisms underlying these computations in Caenorhabditis elegans. By characterizing neuronal calcium responses to rapidly fluctuating odor sequences, we show that sensory neurons reliably track stimulus fluctuations relevant to behavior. AWC olfactory neurons respond to multiple odors with subsecond precision required for chemotaxis, whereas ASH nociceptive neurons integrate noxious cues over several seconds to reach a threshold for avoidance behavior...
February 5, 2014: Neuron
https://www.readbyqxmd.com/read/24347628/multigenic-natural-variation-underlies-caenorhabditis-elegans-olfactory-preference-for-the-bacterial-pathogen-serratia-marcescens
#19
Elizabeth E Glater, Matthew V Rockman, Cornelia I Bargmann
The nematode Caenorhabditis elegans can use olfaction to discriminate among different kinds of bacteria, its major food source. We asked how natural genetic variation contributes to choice behavior, focusing on differences in olfactory preference behavior between two wild-type C. elegans strains. The laboratory strain N2 strongly prefers the odor of Serratia marcescens, a soil bacterium that is pathogenic to C. elegans, to the odor of Escherichia coli, a commonly used laboratory food source. The divergent Hawaiian strain CB4856 has a weaker attraction to Serratia than the N2 strain, and this behavioral difference has a complex genetic basis...
February 2014: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/24145415/high-throughput-imaging-of-neuronal-activity-in-caenorhabditis-elegans
#20
Johannes Larsch, Donovan Ventimiglia, Cornelia I Bargmann, Dirk R Albrecht
Neuronal responses to sensory inputs can vary based on genotype, development, experience, or stochastic factors. Existing neuronal recording techniques examine a single animal at a time, limiting understanding of the variability and range of potential responses. To scale up neuronal recordings, we here describe a system for simultaneous wide-field imaging of neuronal calcium activity from at least 20 Caenorhabditis elegans animals under precise microfluidic chemical stimulation. This increased experimental throughput was used to perform a systematic characterization of chemosensory neuron responses to multiple odors, odor concentrations, and temporal patterns, as well as responses to pharmacological manipulation...
November 5, 2013: Proceedings of the National Academy of Sciences of the United States of America
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