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https://www.readbyqxmd.com/read/28918266/nanomedicine-for-safe-healing-of-bone-trauma-opportunities-and-challenges
#1
REVIEW
Shahed Behzadi, Gaurav A Luther, Mitchel B Harris, Omid C Farokhzad, Morteza Mahmoudi
Historically, high-energy extremity injuries resulting in significant soft-tissue trauma and bone loss were often deemed unsalvageable and treated with primary amputation. With improved soft-tissue coverage and nerve repair techniques, these injuries now present new challenges in limb-salvage surgery. High-energy extremity trauma is pre-disposed to delayed or unpredictable bony healing and high rates of infection, depending on the integrity of the soft-tissue envelope. Furthermore, orthopedic trauma surgeons are often faced with the challenge of stabilizing and repairing large bony defects while promoting an optimal environment to prevent infection and aid bony healing...
September 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28917712/toward-classification-criteria-for-early-osteoarthritis-of-the-knee
#2
F P Luyten, S Bierma-Zeinstra, F Dell'Accio, V B Kraus, K Nakata, I Sekiya, N K Arden, L S Lohmander
OBJECTIVE: To propose draft classification criteria for early stage osteoarthritis (OA) of the knee for use in a primary care setting. METHODS: A group of basic scientists, physician-scientists, rheumatologists, orthopedic surgeons, and physiotherapists in a workshop setting discussed potential classification criteria for early osteoarthritis of the knee. The workshop was divided into sessions around relevant topics with short state of the art presentations followed by breakout sessions, consensus discussions, and consolidation into a consensus document...
August 9, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28917092/progressive-halo-vest-traction-preceding-posterior-occipitocervical-instrumented-fusion-for-irreducible-atlantoaxial-dislocation-and-basilar-invagination
#3
Peng Li, Deming Bao, Huijuan Cheng, Fanshuai Meng, Junwei Li
OBJECTIVES: Surgical treatment of irreducible atlantoaxial dislocation (IAAD) with basilar invagination (BI) is associated with high rates of severe complications, including mortality. This retrospective study investigated the safety and efficacy of progressive halo-vest traction for IAAD with BI prior to posterior occipitocervical instrumented fusion. PATIENTS AND METHODS: Between 2009 and 2013, 39 patients with IAAD with BI underwent preoperative reduction by progressive halo-vest traction for 20...
September 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28916228/cellular-therapy-injections-in-today-s-orthopedic-market-a-social-media-analysis
#4
Prem N Ramkumar, Sergio M Navarro, Heather S Haeberle, Morad Chughtai, Christopher Demetriades, Nicolas S Piuzzi, Michael A Mont, Thomas W Bauer, George F Muschler
BACKGROUND: The current state of cellular therapy for musculoskeletal conditions is at a crossroads. Marketing efforts are often outpacing clinical evidence and regulatory control. QUESTIONS/PURPOSES: This study was an effort to describe the marketing of cellular therapy in musculoskeletal medicine by evaluating the content in popular social media channels. Specifically, media posts were evaluated for the following: (1) perspective, (2) tone, (3) content and (4) visibility...
September 12, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28914105/bone-and-subcutaneous-adipose-tissue-pharmacokinetics-of-vancomycin-in-total-knee-replacement-patients
#5
Mats Bue, Mikkel Tøttrup, Pelle Hanberg, Otto Langhoff, Hanne Birke-Sørensen, Theis M Thillemann, Torben L Andersson, Kjeld Søballe
Background and purpose - The incidence of orthopedic methicillin-resistant Staphylococcus aureus (MRSA) infections is increasing. Vancomycin may therefore play an increasingly important role in orthopedic perioperative antimicrobial prophylaxis. Studies investigating perioperative bone and soft tissue concentrations of vancomycin are sparse and challenged by a lack of appropriate methods. We assessed single-dose plasma, subcutaneous adipose tissue (SCT) and bone concentrations of vancomycin using microdialysis in male patients undergoing total knee replacement...
September 15, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28913380/questionable-word-choice-in-scientific-writing-in-orthopedic-surgery
#6
Casey M O'Connor, Mariano E Menendez, Kevin Hughes, David Ring
BACKGROUND: Given the strong influence of thoughts, emotions, and behaviors on musculoskeletal symptoms and limitations it's important that both scientific and lay writing use the most positive, hopeful, and adaptive words and concepts consistent with medical evidence. The use of words that might reinforce misconceptions about preference-sensitive conditions (particularly those associated with age) could increase symptoms and limitations and might also distract patients from the treatment preferences they would select when informed and at ease...
July 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28913375/important-lessons-learned-from-nearly-a-half-century-of-orthopedic-practice
#7
EDITORIAL
Andrew N Fleischman, Richard H Rothman
No abstract text is available yet for this article.
July 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28913138/chondrosarcoma-mimicking-an-adnexal-mass-a-very-rare-case-report
#8
Hüseyin Çağlayan Özcan, Aynur Mustafa, Zehra Bozdağ, Seyhun Sucu, Özcan Balat
Chondrosarcoma is considered as a common primary bone sarcoma. These sarcomas can form large masses without any specific symptoms because there are no barriers in pelvic anatomy to prevent the enlargement of tumors, and can mimic ovarian masses. We present a pelvic chondrosarcoma in a woman aged 37 years who was misdiagnosed as having an ovarian mass due to the limited information obtained from imaging studies. Pelvic chondrosarcoma should be considered in patients who have pelvic masses with solid components...
March 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28912628/the-future-of-orthopedic-manual-therapy-what-are-we-missing
#9
EDITORIAL
Cristiana K Collins, Michael Masaracchio, Jean-Michel Brismée
No abstract text is available yet for this article.
September 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28910466/surgical-instrument-sets-for-special-operations-expeditionary-surgical-teams
#10
Diane F Hale, Justin C Sexton, Linda C Benavides, Jerry M Benavides, Jonathan B Lundy
BACKGROUND: The deployment of surgical assets has been driven by mission demands throughout years of military operations in Iraq and Afghanistan. The transition to the highly expeditious Golden Hour Offset Surgical Transport Team (GHOST- T) now offers highly mobile surgical assets in nontraditional operating rooms; the content of the surgical instrument sets has also transformed to accommodate this change. METHODS: The 102nd Forward Surgical Team (FST) was attached to Special Operations assigned to southern Afghanistan from June 2015 to March 2016...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28906396/chondrosarcoma-of-the-patella-a-case-report
#11
Conglin Ye, Zhiping Luo, Jin Zeng, Min Dai
RATIONALE: Chondrosarcoma, characterized by the production of cartilage matrix, is a common bone tumor, accounting for 20% to 27% of all malignant bone tumors. It often occurs in the cartilage of the pelvis, femur, tibia, and humerus. However, chondrosarcoma of the patella is extremely rare. PATIENT CONCERNS: The present study describes a case of chondrosarcoma affecting the right patella in a 68-year-old woman. The chief complaints were painful swelling and limitation of motion of the right knee for about half a year...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28906299/integrated-plastic-surgery-residency-applicant-trends-and-comparison-with-other-surgical-specialties
#12
Jasson T Abraham, Anson V Nguyen, Robert A Weber
BACKGROUND: There has been a relatively rapid increase in the number and size of "integrated" residency programs in plastic surgery (PS) over the past decade. The objective of this study is to evaluate trends of US senior applicants of PS compared with other surgical specialties from 2007 to 2016. METHODS: Data were obtained from "NRMP: Main Residency Match" and from "NRMP: Charting Outcomes in the Match." Frequencies, percentages, and proportions were calculated for categorical variables...
September 12, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28906192/preoperative-risks-for-subsyndromal-delirium-in-older-adults-following-orthopedic-surgery
#13
Dawn L Denny, Glenda Lindseth
No abstract text is available yet for this article.
October 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28904732/-type-iii-monteggia-lesion-a-rare-association-about-a-case
#14
Mohamed Amine Oukhouya, Hind Abou El Jaoud, Saad Andaloussi, Hicham Abdellaoui, Karima Atarraf, Lamia Chater, My Abderrahman Afifi
Type III Monteggia lesion is very rare, usually occurring within a context of violent trauma and often going unnoticed. We report the case of a 11-year old boy presenting to the Emergency Department with blunt trauma of the upper limb. The radiological evaluation showed olecranon fracture and radial epiphyseal separation associated with dislocation of the radial head. The patient underwent orthopedic treatment with good outcome after a mean follow-up of 3 months.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904658/prenatal-diagnosis-of-caudal-regression-syndrome-and-omphalocele-in-a-fetus-of-a-diabetic-mother
#15
Haifa Bouchahda, Houda El Mhabrech, Hechmi Ben Hamouda, Sobhi Ghanmi, Rim Bouchahda, Habib Soua
The caudal regression syndrome is defined as total or partial agenesis of the sacrum and lumbar spine, frequently associated with other developmental malformations (orthopedic, neurological, genito-urinary, gastrointestinal…). Prenatal diagnosis is possible through fetal ultrasound (US) and magnetic resonance imaging (MRI). A case of fetal caudal regression syndrome with omphalocele from a diabetic mother is presented, demonstrating the sonographic, MRI, CT and X-Ray features diagnostic. We will also discuss neonatal findings, risk factors and prognosis of this condition...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904653/-pure-internal-subtalar-dislocation-about-a-case
#16
Mustafa Nkaoui, Moncef Boufettal, Youness Sasbou, Mohammed Kharmaz, Mohamed El Ouadaghiri, Moulay Omar Lamrani, Ahmed El Bardouni, Mustapha Mahfoud, Mohamed Saleh Berrada
Pure subtalar dislocation is a rare condition. We here report the case of a young patient presenting with pure internal subtalar dislocation as a result of a sport accident. He underwent orthopedic therapy achieving a good functional outcome.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904182/finegoldia-magna-isolated-from-orthopedic-joint-implant-associated-infections
#17
Bo Söderquist, Sanna Björklund, Bengt Hellmark, Anders Jensen, Holger Brüggemann
Background: The anaerobic Gram-positive coccus Finegoldia magna is a rare cause of infections of bone and joints. The aim of this study was to describe the microbiological and clinical characteristics of orthopedic implant-associated infections caused by F. magnaMethods: We retrospectively analyzed samples consisting of anaerobic Gram-positive cocci and samples already identified as F. magna from patients with orthopedic infections. The isolates found were determined to species level by MALDI-TOF MS. The antibiotic susceptibility pattern was determined by Etest...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28903883/the-natural-history-of-the-patients-with-duchenne-muscular-dystrophy-in-taiwan-a-medical-center-experience
#18
Wen-Chen Liang, Chen-Hua Wang, Po-Ching Chou, Wan-Zi Chen, Yuh-Jyh Jong
BACKGROUND: Duchenne muscular dystrophy (DMD) is the most common hereditary muscular dystrophy and caused by DMD gene mutation. In addition to progressive proximal muscle weakness, respiratory, orthopedic, and gastrointestinal complications are often observed in DMD. The natural history of patients with DMD in Taiwan has not been reported thus far. METHODS: Medical records of 39 patients who received a diagnosis of DMD between 1999 and 2016 at Kaohsiung Medical University Hospital were reviewed...
August 25, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28902923/molecular-microbiological-and-clinical-characterization-of-clostridium-difficile-isolates-from-tertiary-care-hospitals-in-colombia
#19
Clara Lina Salazar, Catalina Reyes, Santiago Atehortua, Patricia Sierra, Margarita María Correa, Daniel Paredes-Sabja, Emma Best, Warren N Fawley, Mark Wilcox, Ángel González
In Colombia, the epidemiology and circulating genotypes of Clostridium difficile have not yet been described. Therefore, we molecularly characterized clinical isolates of C.difficile from patients with suspicion of C.difficile infection (CDI) in three tertiary care hospitals. C.difficile was isolated from stool samples by culture, the presence of A/B toxins were detected by enzyme immunoassay, cytotoxicity was tested by cell culture and the antimicrobial susceptibility determined. After DNA extraction, tcdA, tcdB and binary toxin (CDTa/CDTb) genes were detected by PCR, and PCR-ribotyping performed...
2017: PloS One
https://www.readbyqxmd.com/read/28902861/epigenetic-regulation-of-metalloproteinases-and-their-inhibitors-in-rotator-cuff-tears
#20
Mariana Ferreira Leal, Leonardo Caires Dos Santos, Adrielle Martins de Oliveira, Paulo Santoro Belangero, Eduardo Antônio Figueiredo, Carina Cohen, Felipe de Seixas Alves, Wânia Hiromi Yanaguizawa, Carlos Vicente Andreoli, Alberto de Castro Pochini, Benno Ejnisman, Marília Cardoso Smith, Maria Teresa de Seixas Alves, Moises Cohen
Rotator cuff tear is a common orthopedic condition. Metalloproteinases (MMP) and their inhibitors (TIMP) seem to play a role in the development of joint injuries and in the failure of tissue healing. However, the mechanisms of regulation of gene expression in tendons are still unknown. Epigenetic mechanisms, such as DNA methylation and microRNAs regulation, are involved in the dynamic control of gene expression. Here, the mRNA expression and DNA methylation status of MMPs (MMP1, MMP2, MMP3, MMP9, MMP13, and MMP14) and TIMPs (TIMP1-3) and the expression of miR-29 family members in ruptured supraspinatus tendons were compared with non-injured tendons of individuals without this lesion...
2017: PloS One
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