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Richard Axel

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https://www.readbyqxmd.com/read/29731238/human-heart-transplantation-from-donation-after-circulatory-determined-death-donors-using-normothermic-regional-perfusion-and-cold-storage
#1
Simon Messer, Aravinda Page, Simon Colah, Richard Axell, Barbora Parizkova, Steven Tsui, Stephen Large
Heart transplantation from donation after circulatory-determined-death (DCD) donors is emerging as an additional avenue to increase heart transplant activity. Previous methods of DCD heart retrieval include direct procurement and cold storage, direct procurement, and machine perfusion and normothermic regional perfusion, followed by machine perfusion during transportation. Herein we report a further technique resulting in successful DCD heart transplantation utilizing normothermic regional perfusion and permitting functional assessment followed by cold storage...
March 30, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29720733/adding-dasatinib-to-intensive-treatment-in-core-binding-factor-acute-myeloid-leukemia-results-of-the-amlsg-11-08-trial
#2
Peter Paschka, Richard F Schlenk, Daniela Weber, Axel Benner, Lars Bullinger, Michael Heuser, Verena I Gaidzik, Felicitas Thol, Mridul Agrawal, Veronica Teleanu, Michael Lübbert, Walter Fiedler, Markus Radsak, Jürgen Krauter, Heinz-A Horst, Richard Greil, Karin Mayer, Andrea Kündgen, Uwe Martens, Gerhard Heil, Helmut R Salih, Bernd Hertenstein, Carsten Schwänen, Gerald Wulf, Elisabeth Lange, Michael Pfreundschuh, Mark Ringhoffer, Michael Girschikofsky, Thomas Heinicke, Doris Kraemer, Gudrun Göhring, Arnold Ganser, Konstanze Döhner, Hartmut Döhner
In this phase Ib/IIa study (ClinicalTrials.gov Identifier: NCT00850382) of the German-Austrian AML Study Group (AMLSG) the multikinase inhibitor dasatinib was added to intensive induction and consolidation chemotherapy and administered as single agent for 1-year maintenance in first-line treatment of adult patients with core-binding factor (CBF) acute myeloid leukemia (AML). The primary combined end point in this study was safety and feasibility, and included the rates of early (ED) and hypoplastic (HD) deaths, pleural/pericardial effusion 3°/4° and liver toxicity 3°/4°, and the rate of refractory disease...
April 17, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29713818/right-ventriculo-arterial-uncoupling-and-impaired-contractile-reserve-in-obese-patients-with-unexplained-exercise-intolerance
#3
Colm McCabe, Rudolf K F Oliveira, Farbod Rahaghi, Mariana Faria-Urbina, Luke Howard, Richard G Axell, Andrew N Priest, Aaron B Waxman, David M Systrom
BACKGROUND: Right ventricular (RV) dysfunction and heart failure with preserved ejection fraction may contribute to exercise intolerance in obesity. To further define RV exercise responses, we investigated RV-arterial coupling in obesity with and without development of exercise pulmonary venous hypertension (ePVH). METHODS: RV-arterial coupling defined as RV end-systolic elastance/pulmonary artery elastance (Ees/Ea) was calculated from invasive cardiopulmonary exercise test data in 6 controls, 8 obese patients without ePVH (Obese-ePVH) and 8 obese patients with ePVH (Obese+ePVH) within a larger series...
April 30, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29706585/odor-perception-on-the-two-sides-of-the-brain-consistency-despite-randomness
#4
Evan S Schaffer, Dan D Stettler, Daniel Kato, Gloria B Choi, Richard Axel, L F Abbott
Neurons in piriform cortex receive input from a random collection of glomeruli, resulting in odor representations that lack the stereotypic organization of the olfactory bulb. We have performed in vivo optical imaging and mathematical modeling to demonstrate that correlations are retained in the transformation from bulb to piriform cortex, a feature essential for generalization across odors. Random connectivity also implies that the piriform representation of a given odor will differ among different individuals and across brain hemispheres in a single individual...
April 21, 2018: Neuron
https://www.readbyqxmd.com/read/29662977/handheld-skin-printer-in-situ-formation-of-planar-biomaterials-and-tissues
#5
Navid Hakimi, Richard Cheng, Lian Leng, Mohammad Sotoudehfar, Phoenix Qing Ba, Nazihah Bakhtyar, Saeid Amini-Nik, Marc G Jeschke, Axel Günther
We present a handheld skin printer that enables the in situ formation of biomaterial and skin tissue sheets of different homogeneous and architected compositions. When manually positioned above a target surface, the compact instrument (weight <0.8 kg) conformally deposits a biomaterial or tissue sheet from a microfluidic cartridge. Consistent sheet formation is achieved by coordinating the flow rates at which bioink and cross-linker solution are delivered, with the speed at which a pair of rollers actively translate the cartridge along the surface...
April 17, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29580697/intravesical-recurrence-after-bladder-sparing-treatment-of-small-cell-carcinoma-of-the-bladder-characteristics-treatment-and-outcome
#6
Maaike van de Kamp, Richard Meijer, Floris Pos, Martijn Kerst, Eric van Werkhoven, Bas van Rhijn, Simon Horenblas, Axel Bex
INTRODUCTION: Small cell carcinoma of the bladder (SCCB) is a rare and lethal disease. Previously, we and others have reported a bladder sparing strategy with platinum-etoposide-based chemotherapy followed by radiotherapy of the bladder. Little is known on frequency and treatment of intravesical recurrence following this approach. The objective of this study is to describe the incidence of intravesical recurrences and their management. MATERIALS AND METHODS: Retrospective study including all patients with SCCB treated at a single institution from 1993 until 2016...
March 23, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29571946/nilotinib-in-locally-advanced-pigmented-villonodular-synovitis-a-multicentre-open-label-single-arm-phase-2-trial
#7
Hans Gelderblom, Claire Cropet, Christine Chevreau, Richard Boyle, Martin Tattersall, Silvia Stacchiotti, Antoine Italiano, Sophie Piperno-Neumann, Axel Le Cesne, Virginia Ferraresi, Nicolas Penel, Florence Duffaud, Philippe Cassier, Maud Toulmonde, Paolo Casali, Sophie Taieb, Séverine Guillemaut, Séverine Metzger, David Pérol, Jean-Yves Blay
BACKGROUND: Pigmented villonodular synovitis (alternatively known as diffuse-type giant cell tumour) is a rare, locally aggressive tumour driven by a specific translocation resulting in the overexpression of colony-stimulating factor 1 (CSF1). CSF1 receptor (CSF1R) inhibitors (ie, tyrosine kinase inhibitors and antibodies) induce a response in patients with pigmented villonodular synovitis. We investigated the safety and efficacy of a CSF1R tyrosine kinase inhibitor, nilotinib, in patients with locally advanced non-resectable pigmented villonodular synovitis...
March 20, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29563435/meth-mouth-a-growing-epidemic-in-dentistry
#8
Andreas Pabst, Juan Carlos Castillo-Duque, Axel Mayer, Marcus Klinghuber, Richard Werkmeister
In the past two decades, the synthetic style and fashion drug "crystal meth" ("crystal", "meth"), chemically representing the crystalline form of the methamphetamine hydrochloride, has become more and more popular in the United States, in Eastern Europe, and just recently in Central and Western Europe. "Meth" is cheap, easy to synthesize and to market, and has an extremely high potential for abuse and dependence. As a strong sympathomimetic, "meth" has the potency to switch off hunger, fatigue and, pain while simultaneously increasing physical and mental performance...
October 30, 2017: Dentistry journal
https://www.readbyqxmd.com/read/29525381/long-term-outcomes-of-follow-up-for-initially-localised-clear-cell-renal-cell-carcinoma-recur-database-analysis
#9
Saeed Dabestani, Christian Beisland, Grant D Stewart, Karim Bensalah, Eirikur Gudmundsson, Thomas B Lam, William Gietzmann, Paimaun Zakikhani, Lorenzo Marconi, Sergio Fernandéz-Pello, Serenella Monagas, Samuel P Williams, Christian Torbrand, Thomas Powles, Erik Van Werkhoven, Richard Meijer, Alessandro Volpe, Michael Staehler, Börje Ljungberg, Axel Bex
BACKGROUND: Optimal follow-up (FU) strategy to detect potentially curable (PC) recurrences after treatment of localised clear cell renal cell carcinoma (ccRCC) is unclear. This study retrospectively analysed a large international database to determine recurrence patterns and overall survival (OS), as part of a wider project to issue recommendations on FU protocols. OBJECTIVE: To analyse associations between RCC recurrences in patients with ccRCC, their risk group stratifications, treatments, and subsequent outcomes...
March 7, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29523759/landscape-of-tumor-mutation-load-mismatch-repair-deficiency-and-pd-l1-expression-in-a-large-patient-cohort-of-gastrointestinal-cancers
#10
Mohamed E Salem, Alberto Puccini, Axel Grothey, Derek Raghavan, Richard M Goldberg, Joanne Xiu, W Michael Korn, Benjamin A Weinberg, Jimmy J Hwang, Anthony F Shields, John L Marshall, Philip A Philip, Heinz-Josef Lenz
The efficacy of immunotherapy varies widely among different gastrointestinal cancers. Response to immune checkpoint inhibitors is shown to correlate with tumor mutation load (TML), mismatch repair deficiency (dMMR) status, and programmed cell death-ligand 1 (PD-L1) expression. Herein, we quantify TML, dMMR, and PD-L1 expression and determine their interrelationship in gastrointestinal cancers. Here, a total of 4,125 tumors from 14 different gastrointestinal cancer sites were studied using validated assays. Next-generation sequencing was performed on genomic DNA isolated from formalin-fixed paraffin-embedded tumor specimens using the NextSeq platform...
May 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29513111/granulocyte-monocyte-adsorptive-apheresis-for-the-treatment-of-therapy-refractory-chronic-active-ulcerative-colitis
#11
Axel Dignass, Ayesha Akbar, Daniel C Baumgart, Gilles Bommelaer, Guillaume Bouguen, Guillaume Cadiot, Anton Gillessen, Jean-Charles Grimaud, Ailsa Hart, Syed Hoque, Richard Makins, Christophe Michiels, Jacques Moreau, Purushothaman Premchand, Wolfgang Ramlow, Stefan Schanz, Sreedhar Subramanian, Christian von Tirpitz, Bruno Bonaz
OBJECTIVES: Current options for patients with steroid-dependent, chronic-active ulcerative colitis (UC) with insufficient response/intolerance to immunosuppressants (ISs) and/or biologics are limited. The aim of this study was to assess the long-term outcome of granulocyte/monocyte adsorptive (GMA) apheresis (Adacolumn® ) in this population. MATERIALS AND METHODS: Ninety five adults with steroid-dependent active UC and insufficient response/intolerance to IS and/or TNF inhibitors received 5-8 aphereses in a single induction series of ≤10 weeks...
April 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29510617/light-induced-spin-crossover-in-an-fe-ii-low-spin-complex-enabled-by-surface-adsorption
#12
Sebastian Rohlf, Manuel Gruber, Benedikt M Flöser, Jan Grunwald, Simon Jarausch, Florian Diekmann, Matthias Kalläne, Torben Jasper-Toennies, Axel Buchholz, Winfried Plass, Richard Berndt, Felix Tuczek, Kai Rossnagel
Understanding and controlling the spin-crossover properties of molecular complexes can be of particular interest for potential applications in molecular spintronics. Using near-edge X-ray absorption fine structure spectroscopy, we investigated these properties for a new vacuum-evaporable Fe(II) complex, namely [Fe(pypyr(CF3 )2 )2 (phen)] (pypyr = 2-(2'-pyridyl)pyrrolide, phen = 1,10-phenanthroline). We find that the spin-transition temperature, well above room temperature for the bulk compound, is drastically lowered for molecules arranged in thin films...
April 5, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29463182/registered-replication-report-dijksterhuis-and-van-knippenberg-1998
#13
Michael O'Donnell, Leif D Nelson, Evi Ackermann, Balazs Aczel, Athfah Akhtar, Silvio Aldrovandi, Nasseem Alshaif, Ronald Andringa, Mark Aveyard, Peter Babincak, Nursena Balatekin, Scott A Baldwin, Gabriel Banik, Ernest Baskin, Raoul Bell, Olga Białobrzeska, Angie R Birt, Walter R Boot, Scott R Braithwaite, Jessie C Briggs, Axel Buchner, Desiree Budd, Kathryn Budzik, Lottie Bullens, Richard L Bulley, Peter R Cannon, Katarzyna Cantarero, Joseph Cesario, Stephanie Chambers, Christopher R Chartier, Peggy Chekroun, Clara Chong, Axel Cleeremans, Sean P Coary, Jacob Coulthard, Florien M Cramwinckel, Thomas F Denson, Marcos Díaz-Lago, Theresa E DiDonato, Aaron Drummond, Julia Eberlen, Titus Ebersbach, John E Edlund, Katherine M Finnigan, Justin Fisher, Natalia Frankowska, Efraín García-Sánchez, Frank D Golom, Andrew J Graves, Kevin Greenberg, Mando Hanioti, Heather A Hansen, Jenna A Harder, Erin R Harrell, Andree Hartanto, Michael Inzlicht, David J Johnson, Andrew Karpinski, Victor N Keller, Olivier Klein, Lina Koppel, Emiel Krahmer, Anthony Lantian, Michael J Larson, Jean-Baptiste Légal, Richard E Lucas, Dermot Lynott, Corey M Magaldino, Karlijn Massar, Matthew T McBee, Neil McLatchie, Nadhilla Melia, Michael C Mensink, Laura Mieth, Samantha Moore-Berg, Geraldine Neeser, Ben R Newell, Marret K Noordewier, Asil Ali Özdoğru, Myrto Pantazi, Michał Parzuchowski, Kim Peters, Michael C Philipp, Monique M H Pollmann, Panagiotis Rentzelas, Rosa Rodríguez-Bailón, Jan Philipp Röer, Ivan Ropovik, Nelson A Roque, Carolina Rueda, Bastiaan T Rutjens, Katey Sackett, Janos Salamon, Ángel Sánchez-Rodríguez, Blair Saunders, Juliette Schaafsma, Michael Schulte-Mecklenbeck, David R Shanks, Martin F Sherman, Kenneth M Steele, Niklas K Steffens, Jessie Sun, Kyle J Susa, Barnabas Szaszi, Aba Szollosi, Ricardo M Tamayo, Gustav Tinghög, Yuk-Yue Tong, Carol Tweten, Miguel A Vadillo, Deisy Valcarcel, Nicolas Van der Linden, Michiel van Elk, Frenk van Harreveld, Daniel Västfjäll, Simine Vazire, Philippe Verduyn, Matt N Williams, Guillermo B Willis, Sarah E Wood, Chunliang Yang, Oulmann Zerhouni, Robert Zheng, Mark Zrubka
Dijksterhuis and van Knippenberg (1998) reported that participants primed with a category associated with intelligence ("professor") subsequently performed 13% better on a trivia test than participants primed with a category associated with a lack of intelligence ("soccer hooligans"). In two unpublished replications of this study designed to verify the appropriate testing procedures, Dijksterhuis, van Knippenberg, and Holland observed a smaller difference between conditions (2%-3%) as well as a gender difference: Men showed the effect (9...
March 2018: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29441119/diagnosis-monitoring-and-prevention-of-exposure-related-non-communicable-diseases-in-the-living-and-working-environment-dimopex-project-is-designed-to-determine-the-impacts-of-environmental-exposure-on-human-health
#14
REVIEW
Lygia Therese Budnik, Balazs Adam, Maria Albin, Barbara Banelli, Xaver Baur, Fiorella Belpoggi, Claudia Bolognesi, Karin Broberg, Per Gustavsson, Thomas Göen, Axel Fischer, Dorota Jarosinska, Fabiana Manservisi, Richard O'Kennedy, Johan Øvrevik, Elizabet Paunovic, Beate Ritz, Paul T J Scheepers, Vivi Schlünssen, Heidi Schwarzenbach, Per E Schwarze, Orla Sheils, Torben Sigsgaard, Karel Van Damme, Ludwine Casteleyn
The WHO has ranked environmental hazardous exposures in the living and working environment among the top risk factors for chronic disease mortality. Worldwide, about 40 million people die each year from noncommunicable diseases (NCDs) including cancer, diabetes, and chronic cardiovascular, neurological and lung diseases. The exposure to ambient pollution in the living and working environment is exacerbated by individual susceptibilities and lifestyle-driven factors to produce complex and complicated NCD etiologies...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29432167/phylogenetic-classification-of-the-world-s-tropical-forests
#15
J W Ferry Slik, Janet Franklin, Víctor Arroyo-Rodríguez, Richard Field, Salomon Aguilar, Nikolay Aguirre, Jorge Ahumada, Shin-Ichiro Aiba, Luciana F Alves, Anitha K, Andres Avella, Francisco Mora, Gerardo A Aymard C, Selene Báez, Patricia Balvanera, Meredith L Bastian, Jean-François Bastin, Peter J Bellingham, Eduardo van den Berg, Polyanna da Conceição Bispo, Pascal Boeckx, Katrin Boehning-Gaese, Frans Bongers, Brad Boyle, Fabian Brambach, Francis Q Brearley, Sandra Brown, Shauna-Lee Chai, Robin L Chazdon, Shengbin Chen, Phourin Chhang, George Chuyong, Corneille Ewango, Indiana M Coronado, Jurgi Cristóbal-Azkarate, Heike Culmsee, Kipiro Damas, H S Dattaraja, Priya Davidar, Saara J DeWalt, Hazimah Din, Donald R Drake, Alvaro Duque, Giselda Durigan, Karl Eichhorn, Eduardo Schmidt Eler, Tsutomu Enoki, Andreas Ensslin, Adandé Belarmain Fandohan, Nina Farwig, Kenneth J Feeley, Markus Fischer, Olle Forshed, Queila Souza Garcia, Satish Chandra Garkoti, Thomas W Gillespie, Jean-Francois Gillet, Christelle Gonmadje, Iñigo Granzow-de la Cerda, Daniel M Griffith, James Grogan, Khalid Rehman Hakeem, David J Harris, Rhett D Harrison, Andy Hector, Andreas Hemp, Jürgen Homeier, M Shah Hussain, Guillermo Ibarra-Manríquez, I Faridah Hanum, Nobuo Imai, Patrick A Jansen, Carlos Alfredo Joly, Shijo Joseph, Kuswata Kartawinata, Elizabeth Kearsley, Daniel L Kelly, Michael Kessler, Timothy J Killeen, Robert M Kooyman, Yves Laumonier, Susan G Laurance, William F Laurance, Michael J Lawes, Susan G Letcher, Jeremy Lindsell, Jon Lovett, Jose Lozada, Xinghui Lu, Anne Mette Lykke, Khairil Bin Mahmud, Ni Putu Diana Mahayani, Asyraf Mansor, Andrew R Marshall, Emanuel H Martin, Darley Calderado Leal Matos, Jorge A Meave, Felipe P L Melo, Zhofre Huberto Aguirre Mendoza, Faizah Metali, Vincent P Medjibe, Jean Paul Metzger, Thiago Metzker, D Mohandass, Miguel A Munguía-Rosas, Rodrigo Muñoz, Eddy Nurtjahy, Eddie Lenza de Oliveira, Onrizal, Pia Parolin, Marc Parren, N Parthasarathy, Ekananda Paudel, Rolando Perez, Eduardo A Pérez-García, Ulf Pommer, Lourens Poorter, Lan Qie, Maria Teresa F Piedade, José Roberto Rodrigues Pinto, Axel Dalberg Poulsen, John R Poulsen, Jennifer S Powers, Rama Chandra Prasad, Jean-Philippe Puyravaud, Orlando Rangel, Jan Reitsma, Diogo S B Rocha, Samir Rolim, Francesco Rovero, Andes Rozak, Kalle Ruokolainen, Ervan Rutishauser, Gemma Rutten, Mohd Nizam Mohd Said, Felipe Z Saiter, Philippe Saner, Braulio Santos, João Roberto Dos Santos, Swapan Kumar Sarker, Christine B Schmitt, Jochen Schoengart, Mark Schulze, Douglas Sheil, Plinio Sist, Alexandre F Souza, Wilson Roberto Spironello, Tereza Sposito, Robert Steinmetz, Tariq Stevart, Marcio Seiji Suganuma, Rahayu Sukri, Aisha Sultana, Raman Sukumar, Terry Sunderland, Supriyadi, H S Suresh, Eizi Suzuki, Marcelo Tabarelli, Jianwei Tang, Ed V J Tanner, Natalia Targhetta, Ida Theilade, Duncan Thomas, Jonathan Timberlake, Márcio de Morisson Valeriano, Johan van Valkenburg, Tran Van Do, Hoang Van Sam, John H Vandermeer, Hans Verbeeck, Ole Reidar Vetaas, Victor Adekunle, Simone A Vieira, Campbell O Webb, Edward L Webb, Timothy Whitfeld, Serge Wich, John Williams, Susan Wiser, Florian Wittmann, Xiaobo Yang, C Yves Adou Yao, Sandra L Yap, Rakan A Zahawi, Rahmad Zakaria, Runguo Zang
Knowledge about the biogeographic affinities of the world's tropical forests helps to better understand regional differences in forest structure, diversity, composition, and dynamics. Such understanding will enable anticipation of region-specific responses to global environmental change. Modern phylogenies, in combination with broad coverage of species inventory data, now allow for global biogeographic analyses that take species evolutionary distance into account. Here we present a classification of the world's tropical forests based on their phylogenetic similarity...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29397361/neurocognition-and-cerebral-lesion-burden-in-high-risk-patients-before-undergoing-transcatheter-aortic-valve-replacement-insights-from-the-sentinel-trial
#16
RANDOMIZED CONTROLLED TRIAL
Ronald M Lazar, Marykathryn A Pavol, Tobias Bormann, Michael G Dwyer, Carlye Kraemer, Roseann White, Robert Zivadinov, Jeffrey C Wertheimer, Angelika Thöne-Otto, Lisa D Ravdin, Richard Naugle, Dawn Mechanic-Hamilton, William S Garmoe, Anthony Y Stringer, Heidi A Bender, Samir R Kapadia, Susheel Kodali, Alexander Ghanem, Axel Linke, Roxana Mehran, Renu Virmani, Tamim Nazif, Azin Parhizgar, Martin B Leon
OBJECTIVES: The authors sought to determine baseline neurocognition before transcatheter aortic valve replacement (TAVR) and its correlations with pre-TAVR brain imaging. BACKGROUND: TAVR studies have not shown a correlation between diffusion-weighted image changes and neurocognition. The authors wanted to determine the extent to which there was already impairment at baseline that correlated with cerebrovascular disease. METHODS: SENTINEL (Cerebral Protection in Transcatheter Aortic Valve Replacement) trial patients had cognitive assessments of attention, processing speed, executive function, and verbal and visual memory...
February 26, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29352254/author-correction-long-term-carbon-sink-in-borneo-s-forests-halted-by-drought-and-vulnerable-to-edges
#17
Lan Qie, Simon L Lewis, Martin J P Sullivan, Gabriela Lopez-Gonzalez, Georgia C Pickavance, Terry Sunderland, Peter Ashton, Wannes Hubau, Kamariah Abu Salim, Shin-Ichiro Aiba, Lindsay F Banin, Nicholas Berry, Francis Q Brearley, David F R P Burslem, Martin Dančák, Stuart J Davies, Gabriella Fredriksson, Keith C Hamer, Radim Hédl, Lip Khoon Kho, Kanehiro Kitayama, Haruni Krisnawati, Stanislav Lhota, Yadvinder Malhi, Colin Maycock, Faizah Metali, Edi Mirmanto, Laszlo Nagy, Reuben Nilus, Robert Ong, Colin A Pendry, Axel Dalberg Poulsen, Richard B Primack, Ervan Rutishauser, Ismayadi Samsoedin, Bernaulus Saragih, Plinio Sist, J W Ferry Slik, Rahayu Sukmaria Sukri, Martin Svátek, Sylvester Tan, Aiyen Tjoa, Mark van Nieuwstadt, Ronald R E Vernimmen, Ishak Yassir, Petra Susan Kidd, Muhammad Fitriadi, Nur Khalish Hafizhah Ideris, Rafizah Mat Serudin, Layla Syaznie Abdullah Lim, Muhammad Shahruney Saparudin, Oliver L Phillips
The original version of this Article contained an error in the third sentence of the abstract and incorrectly read "Here, using long-term plot monitoring records of up to half a century, we find that intact forests in Borneo gained 0.43 Mg C ha-1 year-1 (95% CI 0.14-0.72, mean period 1988-2010) above-ground live biomass", rather than the correct "Here, using long-term plot monitoring records of up to half a century, we find that intact forests in Borneo gained 0.43 Mg C ha-1 year-1 (95% CI 0...
January 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29346117/the-deubiquitinase-usp9x-regulates-fbw7-stability-and-suppresses-colorectal-cancer
#18
Omar M Khan, Joana Carvalho, Bradley Spencer-Dene, Richard Mitter, David Frith, Ambrosius P Snijders, Stephen A Wood, Axel Behrens
The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in several human cancers. We noted that in a substantial percentage of colon cancers, FBW7 protein is undetectable despite the presence of FBW7 mRNA. To understand the molecular mechanism of FBW7 regulation in these cancers, we employed proteomics and identified the deubiquitinase (DUB) USP9X as an FBW7 interactor. USP9X antagonized FBW7 ubiquitylation, and Usp9x deletion caused Fbw7 destabilization. Mice lacking Usp9x in the gut showed reduced secretory cell differentiation and increased progenitor proliferation, phenocopying Fbw7 loss...
April 2, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29330256/osteoprotegerin-is-associated-with-major-bleeding-but-not-with-cardiovascular-outcomes-in-patients-with-acute-coronary-syndromes-insights-from-the-plato-platelet-inhibition-and-patient-outcomes-trial
#19
Thor Ueland, Axel Åkerblom, Tatevik Ghukasyan, Annika E Michelsen, Pål Aukrust, Richard C Becker, Maria Bertilsson, Anders Himmelmann, Stefan K James, Agneta Siegbahn, Robert F Storey, Frederic Kontny, Lars Wallentin
BACKGROUND: Elevated levels of osteoprotegerin, a secreted tumor necrosis factor-related molecule, might be associated with adverse outcomes in patients with coronary artery disease. We measured plasma osteoprotegerin concentrations on hospital admission, at discharge, and at 1 and 6 months after discharge in a predefined subset (n=5135) of patients with acute coronary syndromes in the PLATO (Platelet Inhibition and Patient Outcomes) trial. METHODS AND RESULTS: The associations between osteoprotegerin and the composite end point of cardiovascular death, nonprocedural spontaneous myocardial infarction or stroke, and non-coronary artery bypass grafting major bleeding during 1 year of follow-up were assessed by Cox proportional hazards models...
January 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29301099/from-maps-to-multi-dimensional-network-mechanisms-of-mental-disorders
#20
REVIEW
Urs Braun, Axel Schaefer, Richard F Betzel, Heike Tost, Andreas Meyer-Lindenberg, Danielle S Bassett
The development of advanced neuroimaging techniques and their deployment in large cohorts has enabled an assessment of functional and structural brain network architecture at an unprecedented level of detail. Across many temporal and spatial scales, network neuroscience has emerged as a central focus of intellectual efforts, seeking meaningful descriptions of brain networks and explanatory sets of network features that underlie circuit function in health and dysfunction in disease. However, the tools of network science commonly deployed provide insight into brain function at a fundamentally descriptive level, often failing to identify (patho-)physiological mechanisms that link system-level phenomena to the multiple hierarchies of brain function...
January 3, 2018: Neuron
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