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Richard Axel

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https://www.readbyqxmd.com/read/28077774/tropical-ancient-dna-reveals-relationships-of-the-extinct-bahamian-giant-tortoise-chelonoidis-alburyorum
#1
Christian Kehlmaier, Axel Barlow, Alexander K Hastings, Melita Vamberger, Johanna L A Paijmans, David W Steadman, Nancy A Albury, Richard Franz, Michael Hofreiter, Uwe Fritz
Ancient DNA of extinct species from the Pleistocene and Holocene has provided valuable evolutionary insights. However, these are largely restricted to mammals and high latitudes because DNA preservation in warm climates is typically poor. In the tropics and subtropics, non-avian reptiles constitute a significant part of the fauna and little is known about the genetics of the many extinct reptiles from tropical islands. We have reconstructed the near-complete mitochondrial genome of an extinct giant tortoise from the Bahamas (Chelonoidis alburyorum) using an approximately 1 000-year-old humerus from a water-filled sinkhole (blue hole) on Great Abaco Island...
January 11, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28068728/-a-rare-case-of-coecal-volvulus-after-colonoskopy-due-to-a%C3%A2-mobile-coekum-diagnosis-surgical-therapy-and-postoperative-complications
#2
Christian Beltzer, Axel Geiger, Roland Schmidt, Burkhardt Danz, Amrei Maier, Richard Karpa, Nektarios Dikopoulos
Colonoscopy, either performed as screening or as a therapeutic proceedure, is, in general, very safe with only a few cases of serious complications. Most cases of bleeding after endoscopic polypectomy can be safely managed endoscopically. The rare cases of colonic perforations still have to be managed by surgical intervention. The postpolypectomy-coagulation syndrome and a cecal volvulus are very rare complicatoions after colonoscopy. In the current manuscript, we describe a rare case of a cecal volvulus after routine colonoscopy due to an unknown mobile coecum as a predisposition...
January 9, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28038971/measuring-biomarkers-in-wastewater-as-a-new-source-of-epidemiological-information-current-state-and-future-perspectives
#3
REVIEW
Emma Gracia-Lor, Sara Castiglioni, Richard Bade, Frederic Been, Erika Castrignanò, Adrian Covaci, Iria González-Mariño, Evroula Hapeshi, Barbara Kasprzyk-Hordern, Juliet Kinyua, Foon Yin Lai, Thomas Letzel, Luigi Lopardo, Markus R Meyer, Jake O'Brien, Pedram Ramin, Nikolaos I Rousis, Axel Rydevik, Yeonsuk Ryu, Miguel M Santos, Ivan Senta, Nikolaos S Thomaidis, Sofia Veloutsou, Zhugen Yang, Ettore Zuccato, Lubertus Bijlsma
The information obtained from the chemical analysis of specific human excretion products (biomarkers) in urban wastewater can be used to estimate the exposure or consumption of the population under investigation to a defined substance. A proper biomarker can provide relevant information about lifestyle habits, health and wellbeing, but its selection is not an easy task as it should fulfil several specific requirements in order to be successfully employed. This paper aims to summarize the current knowledge related to the most relevant biomarkers used so far...
December 27, 2016: Environment International
https://www.readbyqxmd.com/read/27991515/a-large-ornithurine-bird-tingmiatornis-arctica-from-the-turonian-high-arctic-climatic-and-evolutionary-implications
#4
Richard K Bono, Julia Clarke, John A Tarduno, Donald Brinkman
Bird fossils from Turonian (ca. 90 Ma) sediments of Axel Heiberg Island (High Canadian Arctic) are among the earliest North American records. The morphology of a large well-preserved humerus supports identification of a new volant, possibly diving, ornithurine species (Tingmiatornis arctica). The new bird fossils are part of a freshwater vertebrate fossil assemblage that documents a period of extreme climatic warmth without seasonal ice, with minimum mean annual temperatures of 14 °C. The extreme warmth allowed species expansion and establishment of an ecosystem more easily able to support large birds, especially in fresh water bodies such as those present in the Turonian High Arctic...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27983764/bendamustine-lenalidomide-and-dexamethasone-brd-has-high-activity-as-2-nd-line-therapy-for-relapsed-and-refractory-multiple-myeloma-a-phase-ii-trial
#5
Ulrich J M Mey, Wolfram Brugger, Heike Schwarb, Stefanie Pederiva, Andreas Schwarzer, Tobias Dechow, Paul Jehner, Jacqueline Rauh, Christian J Taverna, Mathias Schmid, Martin Schmidt-Hieber, Steffen Doerfel, Natalie Fischer, Axel Ruefer, Carsten Ziske, Wolfgang Knauf, Richard Cathomas, Roger von Moos, Felicitas Hitz, Rafael Sauter, Elke Hiendlmeyer, Nathan Cantoni, Mario Bargetzi, Christoph Driessen
The combination of lenalidomide (Revlimid(®) , R) and dexamethasone (d) is a standard regimen for patients with relapsed/refractory multiple myeloma (rrMM). With this regimen, only a small fraction of patients will achieve high quality responses [≥ very good partial response (VGPR)]. The combination of bendamustine (B), lenalidomide and dexamethasone (BRd) has shown high efficacy in patients with advanced rrMM. However, dose-limiting haematotoxicity restricted its use in extensively pre-treated patient populations...
December 16, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27970387/tct-214-glp-1-cardioprotection-against-ischemic-dysfunction-in-humans-is-not-mediated-by-a-mitochondrial-k-atp-dependent-pathway-in-left-ventricular-conductance-catheter-studies
#6
Joel Giblett, Richard Axell, Paul White, Sophie Clarke, Philip Read, Liam McCormick, Adam Brown, Michael O'Sullivan, Nick West, David Dutka, Stephen Hoole
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27956487/sure-i-m-sure-prefrontal-oscillations-support-metacognitive-monitoring-of-decision-making
#7
Martijn E Wokke, Axel Cleeremans, K Richard Ridderinkhof
: Successful decision-making critically involves metacognitive processes such as monitoring and control of our decision process. Metacognition enables agents to adaptively modify on-going behavior and to determine what to do next in situations where external feedback is not (immediately) available. Despite the importance of metacognition for many aspects of life, little is known about how our metacognitive system operates or about what kind of information is used for metacognitive (second-order) judgments...
December 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27916176/functional-assessment-and-transplantation-of-the-donor-heart-after-circulatory-death
#8
Simon J Messer, Richard G Axell, Simon Colah, Paul A White, Marian Ryan, Aravinda A Page, Barbora Parizkova, Kamen Valchanov, Christopher W White, Darren H Freed, Euan Ashley, John Dunning, Martin Goddard, Jayan Parameshwar, Christopher J Watson, Thomas Krieg, Ayyaz Ali, Steven Tsui, Stephen R Large
BACKGROUND: After a severe shortage of brain-dead donors, the demand for heart transplantation has never been greater. In an attempt to increase organ supply, abdominal and lung transplant programs have turned to the donation after circulatory-determined death (DCD) donor. However, because heart function cannot be assessed after circulatory death, DCD heart transplantation was deemed high risk and never adopted routinely. We report a novel method of functional assessment of the DCD heart resulting in a successful clinical program...
December 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27894361/non-human-primate-malaria-parasites-out-of-the-forest-and-into-the-laboratory-corrigendum
#9
Axel Martinelli, Richard Culleton
No abstract text is available yet for this article.
November 29, 2016: Parasitology
https://www.readbyqxmd.com/read/27881709/relationship-between-metformin-use-and-recurrence-and-survival-in-patients-with-resected-stage-iii-colon-cancer-receiving-adjuvant-chemotherapy-results-from-north-central-cancer-treatment-group-n0147-alliance
#10
Preet Paul Singh, Qian Shi, Nathan R Foster, Axel Grothey, Suresh G Nair, Emily Chan, Anthony F Shields, Richard M Goldberg, Sharlene Gill, Morton S Kahlenberg, Frank A Sinicrope, Daniel J Sargent, Steven R Alberts
BACKGROUND: Preclinical and epidemiological data suggest that metformin might have antineoplastic properties against colon cancer (CC). However, the effect of metformin use on patient survival in stage III CC after curative resection is unknown. The survival outcomes were comparable regardless of the duration of metformin use. PATIENTS AND METHODS: Before randomization to FOLFOX (folinic acid, 5-fluorouracil, oxaliplatin) with or without cetuximab, 1,958 patients with stage III CC enrolled in the N0147 study completed a questionnaire with information on diabetes mellitus (DM) and metformin use...
December 2016: Oncologist
https://www.readbyqxmd.com/read/27856902/perovskite-perovskite-tandem-photovoltaics-with-optimized-band-gaps
#11
Giles E Eperon, Tomas Leijtens, Kevin A Bush, Rohit Prasanna, Thomas Green, Jacob Tse-Wei Wang, David P McMeekin, George Volonakis, Rebecca L Milot, Richard May, Axel Palmstrom, Daniel J Slotcavage, Rebecca A Belisle, Jay B Patel, Elizabeth S Parrott, Rebecca J Sutton, Wen Ma, Farhad Moghadam, Bert Conings, Aslihan Babayigit, Hans-Gerd Boyen, Stacey Bent, Feliciano Giustino, Laura M Herz, Michael B Johnston, Michael D McGehee, Henry J Snaith
We demonstrate four- and two-terminal perovskite-perovskite tandem solar cells with ideally matched band gaps. We develop an infrared-absorbing 1.2-electron volt band-gap perovskite, FA0.75Cs0.25Sn0.5Pb0.5I3, that can deliver 14.8% efficiency. By combining this material with a wider-band gap FA0.83Cs0.17Pb(I0.5Br0.5)3 material, we achieve monolithic two-terminal tandem efficiencies of 17.0% with >1.65-volt open-circuit voltage. We also make mechanically stacked four-terminal tandem cells and obtain 20.3% efficiency...
November 18, 2016: Science
https://www.readbyqxmd.com/read/27843641/esmo-asco-recommendations-for-a-global-curriculum-in-medical-oncology-edition-2016
#12
REVIEW
Christian Dittrich, Michael Kosty, Svetlana Jezdic, Doug Pyle, Rossana Berardi, Jonas Bergh, Nagi El-Saghir, Jean-Pierre Lotz, Pia Österlund, Nicholas Pavlidis, Gunta Purkalne, Ahmad Awada, Susana Banerjee, Smita Bhatia, Jan Bogaerts, Jan Buckner, Fatima Cardoso, Paolo Casali, Edward Chu, Julia Lee Close, Bertrand Coiffier, Roisin Connolly, Sarah Coupland, Luigi De Petris, Maria De Santis, Elisabeth G E de Vries, Don S Dizon, Jennifer Duff, Linda R Duska, Alexandru Eniu, Marc Ernstoff, Enriqueta Felip, Martin F Fey, Jill Gilbert, Nicolas Girard, Andor W J M Glaudemans, Priya K Gopalan, Axel Grothey, Stephen M Hahn, Diana Hanna, Christian Herold, Jørn Herrstedt, Krisztian Homicsko, Dennie V Jones, Lorenz Jost, Ulrich Keilholz, Saad Khan, Alexander Kiss, Claus-Henning Köhne, Rainer Kunstfeld, Heinz-Josef Lenz, Stuart Lichtman, Lisa Licitra, Thomas Lion, Saskia Litière, Lifang Liu, Patrick J Loehrer, Merry Jennifer Markham, Ben Markman, Marius Mayerhoefer, Johannes G Meran, Olivier Michielin, Elizabeth Charlotte Moser, Giannis Mountzios, Timothy Moynihan, Torsten Nielsen, Yuichiro Ohe, Kjell Öberg, Antonio Palumbo, Fedro Alessandro Peccatori, Michael Pfeilstöcker, Chandrajit Raut, Scot C Remick, Mark Robson, Piotr Rutkowski, Roberto Salgado, Lidia Schapira, Eva Schernhammer, Martin Schlumberger, Hans-Joachim Schmoll, Lowell Schnipper, Cristiana Sessa, Charles L Shapiro, Julie Steele, Cora N Sternberg, Friedrich Stiefel, Florian Strasser, Roger Stupp, Richard Sullivan, Josep Tabernero, Luzia Travado, Marcel Verheij, Emile Voest, Everett Vokes, Jamie Von Roenn, Jeffrey S Weber, Hans Wildiers, Yosef Yarden
The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) thanks to contribution of 64 ESMO-appointed and 32 ASCO-appointed authors. First published in 2004 and updated in 2010, the GC edition 2016 answers to the need for updated recommendations for the training of physicians in medical oncology by defining the standard to be fulfilled to qualify as medical oncologists. At times of internationalisation of healthcare and increased mobility of patients and physicians, the GC aims to provide state-of-the-art cancer care to all patients wherever they live...
2016: ESMO Open
https://www.readbyqxmd.com/read/27824581/dynamic-scene-recognition-with-complementary-spatiotemporal-features
#13
Christoph Feichtenhofer, Axel Pinz, Richard P Wildes
This paper presents Dynamically Pooled Complementary Features (DPCF), a unified approach to dynamic scene recognition that analyzes a short video clip in terms of its spatial, temporal and color properties. The complementarity of these properties is preserved through all main steps of processing, including primitive feature extraction, coding and pooling. In the feature extraction step, spatial orientations capture static appearance, spatiotemporal oriented energies capture image dynamics and color statistics capture chromatic information...
December 2016: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/27821736/c-terminal-domain-of-mammalian-complexin-1-localizes-to-highly-curved-membranes
#14
Jihong Gong, Ying Lai, Xiaohong Li, Mengxian Wang, Jeremy Leitz, Yachong Hu, Yunxiang Zhang, Ucheor B Choi, Daniel Cipriano, Richard A Pfuetzner, Thomas C Südhof, Xiaofei Yang, Axel T Brunger, Jiajie Diao
In presynaptic nerve terminals, complexin regulates spontaneous "mini" neurotransmitter release and activates Ca(2+)-triggered synchronized neurotransmitter release. We studied the role of the C-terminal domain of mammalian complexin in these processes using single-particle optical imaging and electrophysiology. The C-terminal domain is important for regulating spontaneous release in neuronal cultures and suppressing Ca(2+)-independent fusion in vitro, but it is not essential for evoked release in neuronal cultures and in vitro...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27810152/syndesmosis-reduction-by-computer-assisted-orthopaedic-surgery-with-navigation-feasibility-and-accuracy-in-a-cadaveric-study
#15
Victor Dubois-Ferrière, Axel Gamulin, Ashwin Chowdhary, Jean Fasel, Richard Stern, Mathieu Assal
INTRODUCTION: Syndesmotic disruption may be difficult to reduce and fix, and malreduction is associated with inferior outcomes. Intraoperative computed tomography (CT) can provide accurate assessment of syndesmotic reduction. We hypothesized that three-dimensional (3-D) computer-assisted orthopaedic surgery (CAOS) with navigation of syndesmotic reduction could avoid malreduction. Our goal was to assess feasibility and accuracy of such a technic in a cadaveric study. METHOD: Eleven through-the-knee cadaveric specimens were used...
December 2016: Injury
https://www.readbyqxmd.com/read/27798604/lgr6-labels-a-rare-population-of-mammary-gland-progenitor-cells-that-are-able-to-originate-luminal-mammary-tumours
#16
Leander Blaas, Fabio Pucci, Hendrik A Messal, Agneta B Andersson, E Josue Ruiz, Marco Gerling, Iyadh Douagi, Bradley Spencer-Dene, Alexandra Musch, Richard Mitter, Leena Bhaw, Richard Stone, Dorothee Bornhorst, Abdul K Sesay, Jos Jonkers, Gordon Stamp, Ilaria Malanchi, Rune Toftgård, Axel Behrens
The mammary gland is composed of a complex cellular hierarchy with unusual postnatal plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells that give rise to breast cancer, are incompletely understood. Here we show that Lgr6 marks rare populations of cells in both basal and luminal mammary gland compartments in mice. Lineage tracing analysis showed that Lgr6(+) cells are unipotent progenitors, which expand clonally during puberty but diminish in adulthood. In pregnancy or following stimulation with ovarian hormones, adult Lgr6(+) cells regained proliferative potency and their progeny formed alveoli over repeated pregnancies...
October 31, 2016: Nature Cell Biology
https://www.readbyqxmd.com/read/27748213/non-human-primate-malaria-parasites-out-of-the-forest-and-into-the-laboratory
#17
Axel Martinelli, Richard Culleton
The study of malaria in the laboratory relies on either the in vitro culture of human parasites, or the use of non-human malaria parasites in laboratory animals. In this review, we address the use of non-human primate malaria parasite species (NHPMPs) in laboratory research. We describe the features of the most commonly used NHPMPs, review their contribution to our understanding of malaria to date, and discuss their potential contribution to future studies.
October 17, 2016: Parasitology
https://www.readbyqxmd.com/read/27743922/prognosis-of-patients-with-peritoneal-metastatic-colorectal-cancer-given-systemic-therapy-an-analysis-of-individual-patient-data-from-prospective-randomised-trials-from-the-analysis-and-research-in-cancers-of-the-digestive-system-arcad-database
#18
Jan Franko, Qian Shi, Jeffrey P Meyers, Timothy S Maughan, Richard A Adams, Matthew T Seymour, Leonard Saltz, Cornelis J A Punt, Miriam Koopman, Christophe Tournigand, Niall C Tebbutt, Eduardo Diaz-Rubio, John Souglakos, Alfredo Falcone, Benoist Chibaudel, Volker Heinemann, Joseph Moen, Aimery De Gramont, Daniel J Sargent, Axel Grothey
BACKGROUND: Patients with peritoneal metastatic colorectal cancer have reduced overall survival compared with patients with metastatic colorectal cancer without peritoneal involvement. Here we further investigated the effect of the number and location of metastases in patients receiving first-line systemic chemotherapy. METHODS: We analysed individual patient data for previously untreated patients enrolled in 14 phase 3 randomised trials done between 1997 and 2008...
December 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27717298/prolonged-survival-in-stage-iii-melanoma-with-ipilimumab-adjuvant-therapy
#19
RANDOMIZED CONTROLLED TRIAL
Alexander M M Eggermont, Vanna Chiarion-Sileni, Jean-Jacques Grob, Reinhard Dummer, Jedd D Wolchok, Henrik Schmidt, Omid Hamid, Caroline Robert, Paolo A Ascierto, Jon M Richards, Céleste Lebbé, Virginia Ferraresi, Michael Smylie, Jeffrey S Weber, Michele Maio, Lars Bastholt, Laurent Mortier, Luc Thomas, Saad Tahir, Axel Hauschild, Jessica C Hassel, F Stephen Hodi, Corina Taitt, Veerle de Pril, Gaetan de Schaetzen, Stefan Suciu, Alessandro Testori
Background On the basis of data from a phase 2 trial that compared the checkpoint inhibitor ipilimumab at doses of 0.3 mg, 3 mg, and 10 mg per kilogram of body weight in patients with advanced melanoma, this phase 3 trial evaluated ipilimumab at a dose of 10 mg per kilogram in patients who had undergone complete resection of stage III melanoma. Methods After patients had undergone complete resection of stage III cutaneous melanoma, we randomly assigned them to receive ipilimumab at a dose of 10 mg per kilogram (475 patients) or placebo (476) every 3 weeks for four doses, then every 3 months for up to 3 years or until disease recurrence or an unacceptable level of toxic effects occurred...
November 10, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27711890/applications-general-discussion
#20
Alberto Striolo, Francois Sicard, Luis Liz-Marzán, Catherine Murphy, Anna Roig, Axel Mueller, Javier Reguera, Yu Zhou, Mathias Brust, Leonardo Scarabelli, Luciano Tadiello, Antoine Thill, Irene Yarovsky, Martin Mayer, M Arturo López-Quintela, Christian Kuttner, Estefania Gonzalez Solveyra, Heiko Wolf, Euan Kay, Lucia Pasquato, David Buceta, David Portehault, Hedi Mattoussi, Guillermo González, Roland Faller, David French, Benjamin Abécassis, Molly Stevens, Younan Xia, Richard Jones, Marcin Grzelczak, Matthew Penna, Calum Drummond
No abstract text is available yet for this article.
October 6, 2016: Faraday Discussions
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