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https://www.readbyqxmd.com/read/27931880/predictive-diagnosis-of-major-depression-using-nmr-based-metabolomics-and-least-squares-support-vector-machine
#1
Hong Zheng, Peng Zheng, Liangcai Zhao, Jianmin Jia, Shengli Tang, Pengtao Xu, Peng Xie, Hongchang Gao
BACKGROUND: Major depressive (MD) disorder is a serious psychiatric disorder that can result in suicidal behavior if not treated. The MD diagnosis using a standardized instrument instead of a structured interview will be advantageous for treatment and management of the MD, but so far no such technique exists. We developed an integrated analytical method of NMR-based metabolomics and least squares-support vector machine (LS-SVM) for predictive diagnosis of the MD. METHODS: The metabolite profiles in clinical plasma samples obtained from 72 depressive patients and 54 healthy subjects were analyzed by NMR spectroscopy...
December 5, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27876651/ventral-striatum-functional-connectivity-during-rewards-and-losses-and-symptomatology-in-depressed-patients
#2
Karina Quevedo, Rowena Ng, Hannah Scott, Srivastava Kodavaganti, Garry Smyda, Vaibhav Diwadkar, Mary Phillips
BACKGROUND: The ventral striatum (VS) and striatal network supports goal motivated behavior. Identifying how depressed patients differ in their striatal network during the processing of emotionally salient events is a step towards uncovering biomarkers for diagnosis and treatment. METHODS: 38 depressed and 30 healthy adults completed a task that examined brain activation to the anticipation and receipt of monetary rewards and losses. Data were collected using a 3T Siemens Trio scanner...
November 19, 2016: Biological Psychology
https://www.readbyqxmd.com/read/27873290/aims-and-structure-of-the-german-research-consortium-bipolife-for-the-study-of-bipolar-disorder
#3
REVIEW
Philipp S Ritter, Felix Bermpohl, Oliver Gruber, Martin Hautzinger, Andreas Jansen, Georg Juckel, Tilo Kircher, Martin Lambert, Christoph Mulert, Andrea Pfennig, Andreas Reif, Otto Rienhoff, Thomas G Schulze, Emanuel Severus, Thomas Stamm, Michael Bauer
BACKGROUND: Bipolar disorder is a severe and heterogeneous mental disorder. Despite great advances in neuroscience over the past decades, the precise causative mechanisms at the transmitter, cellular or network level have so far not been unraveled. As a result, individual treatment decisions cannot be tailor-made and the uncertain prognosis is based on clinical characteristics alone. Although a subpopulation of patients have an excellent response to pharmacological monotherapy, other subpopulations have been less well served by the medical system and therefore require more focused attention...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27836463/understanding-epigenetic-architecture-of-suicide-neurobiology-a-critical-perspective
#4
REVIEW
Bhaskar Roy, Yogesh Dwivedi
Current understanding of environmental cross-talk with genetic makeup is found to be mediated through an epigenetic interface which is associated with prominent reversible and heritable changes at gene expression level. Recent emergence of epigenetic modulation in shaping the genetic information has become a key regulatory factor in answering the underlying complexities associated with several mental disorders. A comprehensive understanding of the pertinent changes in the epigenetic makeup of suicide phenotype exhibits a characteristic signature with the possibility of using it as a biomarker to help predict the risk factors associated with suicide...
November 9, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27822318/discovery-and-replication-of-a-peripheral-tissue-dna-methylation-biosignature-to-augment-a-suicide-prediction-model
#5
Makena L Clive, Marco P Boks, Christiaan H Vinkers, Lauren M Osborne, Jennifer L Payne, Kerry J Ressler, Alicia K Smith, Holly C Wilcox, Zachary Kaminsky
BACKGROUND: Suicide is the second leading cause of death among adolescents in the USA, and rates are rising. Methods to identify individuals at risk are essential for implementing prevention strategies, and the development of a biomarker can potentially improve prediction of suicidal behaviors. Prediction of our previously reported SKA2 biomarker for suicide and PTSD is substantially improved by questionnaires assessing perceived stress or anxiety and is therefore reliant on psychological assessment...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27810712/sleep-architecture-parameters-as-a-putative-biomarker-of-suicidal-ideation-in-treatment-resistant-depression
#6
Rebecca A Bernert, David A Luckenbaugh, Wallace C Duncan, Naomi G Iwata, Elizabeth D Ballard, Carlos A Zarate
BACKGROUND: Disturbed sleep may confer risk for suicidal behaviors. Polysomnographic (PSG) sleep parameters have not been systematically evaluated in association with suicidal ideation (SI) among individuals with treatment-resistant depression (TRD). METHODS: This secondary data analysis included 54 TRD individuals (N=30 with major depressive disorder (MDD) and N=24 with bipolar depression (BD)). PSG sleep parameters included Sleep Efficiency (SE), Total Sleep Time (TST), Wakefulness After Sleep Onset (WASO), REM percent/latency, and non-REM (NREM) Sleep Stages 1-4...
October 14, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27748930/mirnas-and-their-role-in-the-correlation-between-schizophrenia-and-cancer-review
#7
E Rizos, N Siafakas, E Skourti, C Papageorgiou, J Tsoporis, T H Parker, D I Christodoulou, D A Spandidos, E Katsantoni, V Zoumpourlis
Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is conversely characterized by an increase in appropriate molecular signaling that stimulates uncontrolled cell proliferation. The rather low risk of developing Ca in patients suffering from SZ is a hypothesis that is still under debate...
October 14, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27660275/associations-of-serum-cytokine-receptor-levels-with-melancholia-staging-of-illness-depressive-and-manic-phases-and-severity-of-depression-in-bipolar-disorder
#8
Marcin Siwek, Magdalena Sowa-Kućma, Krzysztof Styczeń, Paulina Misztak, Rafał J Nowak, Bernadeta Szewczyk, Dominika Dudek, Janusz K Rybakowski, Gabriel Nowak, Michael Maes
To examine cytokine receptor biomarkers in bipolar disorder (BD), we recruited 133 well-phenotyped BD patients and 50 normal controls and measured serum levels of soluble interleukin 1 receptor antagonist (sIL-1RA), soluble interleukin-2 receptor (sIL-2R), sIL-6R, and tumor necrosis factor receptor 60 and 80 kDa (sTNFR60/80). sIL-1RA and sTNFR80 are significantly higher in BD than in controls and sTNFR80 and higher in melancholic than in non-melancholic patients and controls. Kapczinski's stages 3 + 4 are characterized by lowered sIL-2R and increased sTNFR80 levels...
September 23, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27605454/the-extrinsic-coagulation-pathway-a-biomarker-for-suicidal-behavior-in-major-depressive-disorder
#9
Yongtao Yang, Jin Chen, Chengyu Liu, Liang Fang, Zhao Liu, Jing Guo, Ke Cheng, Chanjuan Zhou, Yuan Zhan, Narayan D Melgiri, Liang Zhang, Jiaju Zhong, Jianjun Chen, Chenglong Rao, Peng Xie
Although an association between major depressive disorder (MDD) and suicide exists, most depressed patients never attempt suicide. An improved understanding of the factors contributing to suicidal risk in MDD can provide direction for suicide predictor development. In MDD suicide attempters (MDD-SA), MDD non-attempters (MDD-NA), and healthy controls (HC) (n = 12 each group), complementary plasma proteomics identified 45 differential proteins mapped to coagulation and inflammation, 25 of which underwent Western blotting...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27521810/design-rationale-and-baseline-characteristics-of-the-randomized-double-blind-phase-ii-clinical-trial-of-ibudilast-in-progressive-multiple-sclerosis
#10
Robert J Fox, Christopher S Coffey, Merit E Cudkowicz, Trevis Gleason, Andrew Goodman, Eric C Klawiter, Kazuko Matsuda, Michelle McGovern, Robin Conwit, Robert Naismith, Akshata Ashokkumar, Robert Bermel, Dixie Ecklund, Maxine Koepp, Jeffrey Long, Sneha Natarajan, Srividya Ramachandran, Thomai Skaramagas, Brenda Thornell, Jon Yankey, Mark Agius, Khurram Bashir, Bruce Cohen, Patricia Coyle, Silvia Delgado, Dana Dewitt, Angela Flores, Barbara Giesser, Myla Goldman, Burk Jubelt, Neil Lava, Sharon Lynch, Augusto Miravalle, Harold Moses, Daniel Ontaneda, Jai Perumal, Michael Racke, Pavle Repovic, Claire Riley, Christopher Severson, Shlomo Shinnar, Valerie Suski, Bianca Weinstock-Gutman, Vijayshree Yadav, Aram Zabeti
BACKGROUND: Primary and secondary progressive multiple sclerosis (MS), collectively called progressive multiple sclerosis (PMS), is characterized by gradual progression of disability. The current anti-inflammatory treatments for MS have little or no efficacy in PMS in the absence of obvious active inflammation. Optimal biomarkers for phase II PMS trials is unknown. Ibudilast is an inhibitor of macrophage migration inhibitor factor and phosphodiesterases-4 and -10 and exhibits possible neuroprotective properties...
September 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27503048/use-of-gene-expression-biomarkers-to-predict-suicidality
#11
Ries Simons
Since the tragic accident of Germanwings flight 4U9525, there has been discussion about methods to identify and prevent suicidality in pilots. Neurogenetic scientists claim that biomarker tests for suicidality as part of healthcare assessments may lead to early identification of suicidal behavior. In this commentary the value of these gene expression biomarkers for aeromedical purposes is evaluated based on relevant literature. It is concluded that the currently identified biomarkers for suicidality need thorough validation before they can be used...
July 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/27463606/positron-emission-tomographic-imaging-of-the-serotonergic-system-and-prediction-of-risk-and-lethality-of-future-suicidal-behavior
#12
Maria A Oquendo, Hanga Galfalvy, Gregory M Sullivan, Jeffrey M Miller, Matthew M Milak, M Elizabeth Sublette, Sebastian Cisneros-Trujillo, Ainsley K Burke, Ramin V Parsey, J John Mann
Importance: Biomarkers that predict suicidal behavior, especially highly lethal behavior, are urgently needed. In cross-sectional studies, individuals with depression who attempt suicide have lower midbrain serotonin transporter binding potential compared with those who do not attempt suicide, and higher serotonin1A binding potential in the raphe nuclei (RN) is associated with greater lethality of past suicide attempts and suicidal intent and ideation. Objectives: To determine whether serotonin transporter binding potential in the lower midbrain predicts future suicide attempts and whether higher RN serotonin1A binding potential predicts future suicidal ideation and intent and lethality of future suicide attempts...
October 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27411502/a-study-on-paracetamol-cardiotoxicity
#13
Udaya Ralapanawa, Kushalee Poornima Jayawickreme, Ekanayake Mudiyanselage Madhushanka Ekanayake, A M S Dhammika Menike Dissanayake
BACKGROUND: Sri Lanka has a high suicide rate, with more than 40 % of poisoning admissions due to overdose of drugs with Paracetamol being the commonest. Data regarding cardiotoxicity to paracetamol is very minimal though hepatotoxicity following poisoning is well studied. Paracetamol cardiotoxicity has rarely been clinically significant and may have well been overlooked. The possibility that paracetamol overdose might be directly cardiotoxic has been the subject of a few reports. Unexplained deaths and electrocardiographic changes associated with paracetamol poisoning have also been reported in which cardiac origin cannot be clearly ruled out...
2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27378071/startle-amplitude-during-unpleasant-pictures-is-greater-in-veterans-with-a-history-of-multiple-suicide-attempts-and-predicts-a-future-suicide-attempt
#14
Erin A Hazlett, Nicholas J Blair, Nicolas Fernandez, Kathryn Mascitelli, M Mercedes Perez-Rodriguez, Antonia S New, Raymond R Goetz, Marianne Goodman
UNLABELLED: Recent studies demonstrate that veterans exhibit higher suicide risk compared with the general U.S. POPULATION: A prior suicide attempt is a well-documented predictor of suicide death. Despite increased attention to clinical risk factors of suicide and efforts to develop psychosocial interventions to reduce suicide risk, the underlying biological factors that confer this risk are not well understood. This study examined affect-modulated startle (AMS) during a series of intermixed unpleasant, neutral, and pleasant pictures in a sample of 108 demographically-matched veterans at low (passive ideators: n = 26) and high risk (active ideators: n = 29; single attempters: n = 28; and multiple attempters: n = 25) for suicide based on the Columbia Suicide Severity Rating Scale...
October 2016: Psychophysiology
https://www.readbyqxmd.com/read/27352637/the-role-of-rumination-in-illness-trajectories-in-youth-linking-trans-diagnostic-processes-with-clinical-staging-models
#15
A B Grierson, I B Hickie, S L Naismith, J Scott
Research in developmental psychopathology and clinical staging models has increasingly sought to identify trans-diagnostic biomarkers or neurocognitive deficits that may play a role in the onset and trajectory of mental disorders and could represent modifiable treatment targets. Less attention has been directed at the potential role of cognitive-emotional regulation processes such as ruminative response style. Maladaptive rumination (toxic brooding) is a known mediator of the association between gender and internalizing disorders in adolescents and is increased in individuals with a history of early adversity...
September 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27324989/brain-derived-neurotrophic-factor-impaired-glucose-metabolism-and-bipolar-disorder-course
#16
Rodrigo B Mansur, Camila M Santos, Lucas B Rizzo, Elson Asevedo, Graccielle R Cunha, Mariane N Noto, Mariana Pedrini, Maiara Zeni-Graiff, Quirino Cordeiro, Maj Vinberg, Flavio Kapczinski, Roger S McIntyre, Elisa Brietzke
OBJECTIVES: The neurotrophin brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker in bipolar disorder (BD). However, current evidence is limited and results have been highly heterogeneous. This study aimed to assess the moderating effect of impaired glucose metabolism (IGM) on plasma levels of BDNF in individuals with BD, and on the relationship between BDNF and variables of illness course. METHODS: We measured and compared the plasma levels of BDNF in individuals with BD (n=57) and healthy controls (n=26)...
June 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27280862/pediatric-mania-the-controversy-between-euphoria-and-irritability
#17
Giulia Serra, Mai Uchida, Claudia Battaglia, Maria Pia Casini, Lavinia De Chiara, Joseph Biederman, Stefano Vicari, Janet Wozniak
Pediatric Bipolar Disorder (BD) is a highly morbid pediatric psychiatric disease, consistently associated with family psychiatric history of mood disorders and associated with high levels of morbidity and disability and with a great risk of suicide. While there is a general consensus on the symptomatology of depression in childhood, the phenomenology of pediatric mania is still highly debated and the course and long-term outcome of pediatric BD still need to be clarified. We reviewed the available studies on the phenomenology of pediatric mania with the aim of summarizing the prevalence, demographics, clinical correlates and course of these two types of pediatric mania...
June 6, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27271499/postmortem-evidence-of-cerebral-inflammation-in-schizophrenia-a-systematic-review
#18
REVIEW
M O Trépanier, K E Hopperton, R Mizrahi, N Mechawar, R P Bazinet
Schizophrenia is a psychiatric disorder which has a lifetime prevalence of ~1%. Multiple candidate mechanisms have been proposed in the pathogenesis of schizophrenia. One such mechanism is the involvement of neuroinflammation. Clinical studies, including neuroimaging, peripheral biomarkers and randomized control trials, have suggested the presence of neuroinflammation in schizophrenia. Many studies have also measured markers of neuroinflammation in postmortem brain samples from schizophrenia patients. The objective of this study was to conduct a systematic search of the literature on neuroinflammation in postmortem brains of schizophrenia patients indexed in MEDLINE, Embase and PsycINFO...
August 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27268281/itraq-technology-based-identification-of-human-peripheral-serum-proteins-associated-with-depression
#19
Q Wang, X Su, X Jiang, X Dong, Y Fan, J Zhang, C Yu, W Gao, S Shi, J Jiang, W Jiang, T Wei
Clinical depression is one of the most common and debilitating psychiatric disorders and contributes to increased risks of disability and suicide. Differentially expressed serum proteins may serve as biomarkers for diagnosing depression. In this study, samples from depressed patients are aggregated into a pool (22×100μL serum was used) and samples from healthy volunteers are aggregated into the other pool (20×100μL serum was used). Isobaric tag for relative and absolute quantitation (iTRAQ) technology and tandem mass spectrometry were employed to screen for differentially expressed serum protein in two separate pools...
August 25, 2016: Neuroscience
https://www.readbyqxmd.com/read/27217151/mood-stress-and-longevity-convergence-on-ank3
#20
S Rangaraju, D F Levey, K Nho, N Jain, K D Andrews, H Le-Niculescu, D R Salomon, A J Saykin, M Petrascheck, A B Niculescu
Antidepressants have been shown to improve longevity in C. elegans. It is plausible that orthologs of genes involved in mood regulation and stress response are involved in such an effect. We sought to understand the underlying biology. First, we analyzed the transcriptome from worms treated with the antidepressant mianserin, previously identified in a large-scale unbiased drug screen as promoting increased lifespan in worms. We identified the most robust treatment-related changes in gene expression, and identified the corresponding human orthologs...
August 2016: Molecular Psychiatry
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