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https://www.readbyqxmd.com/read/29064136/pyridoxamine-a-novel-treatment-for-schizophrenia-with-enhanced-carbonyl-stress
#1
Masanari Itokawa, Mitsuhiro Miyashita, Makoto Arai, Takashi Dan, Katsuyoshi Takahashi, Taro Tokunaga, Kayo Ishimoto, Kazuya Toriumi, Tomoe Ichikawa, Yasue Horiuchi, Akiko Kobori, Satoshi Usami, Takeo Yoshikawa, Naoji Amano, Shinsuke Washizuka, Yuji Okazaki, Toshio Miyata
AIM: The aim of this clinical trial was to obtain proof of concept for high-dose pyridoxamine as a novel treatment for schizophrenia with enhanced carbonyl stress. METHODS: Ten Japanese schizophrenia patients with high plasma pentosidine, which is a representative biomarker of enhanced carbonyl stress, were recruited in a 24 week, open trial in which high-dose pyridoxamine (ranging from 1200 to 2400 mg/day) was administered using a conventional anti-psychotic regimen...
October 24, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28979823/single-nucleotide-polymorphisms-and-the-central-nervous-system-potential-biomarkers-in-identifying-suicide-risk
#2
REVIEW
Atmaram Yarlagadda, Kevin P Rosenblatt, Anita H Clayton
The rate of completed suicides continues to rise across nations, cultures, socioeconomic classes, age groups, sexes, military personnel, veterans, and civilians from different backgrounds. Most concerning is the absence of diagnosed mental health disorders in the majority of these cases, per current literature reports. Efforts in the identification and possible prevention of this ultimate, tragic act of self-destruction have been minimally successful. In this article, the authors discuss the possible biological mechanisms including the role for potential markers, single nucleotide polymorphisms (SNPs), and their association with suicidal behaviors...
May 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/28960421/circulating-levels-of-brain-derived-neurotrophic-factor-and-history-of-suicide-attempts-in-women
#3
Anastacia Y Kudinova, Terrence Deak, Molly M Deak, Brandon E Gibb
A growing body of research examining biological factors associated with suicidal behaviors highlights the role of brain-derived neurotropic factor (BDNF), involved in neurogenesis and synaptic plasticity. There is evidence suggesting that suicide attempters have lower BDNF levels than those with no history of suicide attempts. The key question addressed in the current investigation is whether differences in circulating BDNF levels persist beyond the current suicidal episode and would be observed in those with a past history of suicide attempts (SA)...
September 28, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28912439/association-between-cognitive-deficits-and-suicidal-ideation-in-patients-with-major-depressive-disorder
#4
Shenghong Pu, Shiori Setoyama, Takamasa Noda
The role of cognitive function in suicidal ideation in patients with major depressive disorder (MDD) has not been adequately explored. This research sought to measure the relationship between suicidal ideation and cognitive function. Therefore, in this study, the association between cognitive function and suicidal ideation in patients with MDD was assessed. Cognitive function was evaluated in 233 patients with MDD using the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS). Suicidal ideation was assessed using item 3 of the Hamilton Depression Rating Scale...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903312/gnp-gapdh1-22-nanovaccines-prevent-neonatal-listeriosis-by-blocking-microglial-apoptosis-and-bacterial-dissemination
#5
Ricardo Calderon-Gonzalez, Elisabet Frande-Cabanes, Hector Teran-Navarro, José María Marimon, Javier Freire, David Salcines-Cuevas, M Carmen Fariñas, Claudia Onzalez-Rico, Marco Marradi, Isabel Garcia, Mirian Alkorta-Gurrutxaga, Aida San Nicolas-Gomez, Ana Castañeda-Sampedro, Sonsoles Yañez-Diaz, Soledad Penades, Carmen Punzon, Javier Gomez-Roman, Fernando Rivera, Manuel Fresno, Carmen Alvarez-Dominguez
Clinical cases of neonatal listeriosis are associated with brain disease and fetal loss due to complications in early or late pregnancy, which suggests that microglial function is altered. This is believed to be the first study to link microglial apoptosis with neonatal listeriosis and listeriosis-associated brain disease, and to propose a new nanovaccine formulation that reverses all effects of listeriosis and confers Listeria monocytogenes (LM)-specific immunity. We examined clinical cases of neonatal listeriosis in 2013-2015 and defined two useful prognostic immune biomarkers to design listeriosis vaccines: high anti-GAPDH1-22 titres and tumor necrosis factor (TNF)/interleukin (IL)-6 ratios...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28886149/plasma-sterols-and-depressive-symptom-severity-in-a-population-based-cohort
#6
Basar Cenik, Can Cenik, Michael P Snyder, E Sherwood Brown
Convergent evidence strongly suggests major depressive disorder is heterogeneous in its etiology and clinical characteristics. Depression biomarkers hold potential for identifying etiological subtypes, improving diagnostic accuracy, predicting treatment response, and personalization of treatment. Human plasma contains numerous sterols that have not been systematically studied. Changes in cholesterol concentrations have been implicated in suicide and depression, suggesting plasma sterols may be depression biomarkers...
2017: PloS One
https://www.readbyqxmd.com/read/28867391/are-there-differences-in-lipid-peroxidation-and-immune-biomarkers-between-major-depression-and-bipolar-disorder-effects-of-melancholia-atypical-depression-severity-of-illness-episode-number-suicidal-ideation-and-prior-suicide-attempts
#7
Magdalena Sowa-Kućma, Krzysztof Styczeń, Marcin Siwek, Paulina Misztak, Rafał J Nowak, Dominika Dudek, Janusz K Rybakowski, Gabriel Nowak, Michael Maes
BACKGROUND: There is evidence that major depression (MDD) and bipolar disorder (BD) are accompanied by activated immune & oxidative (I&O) pathways. METHODS: To compare I&O biomarkers between MDD and BD we assessed serum levels of thiobarbituric acid reactive substances (TBARS; a lipid peroxidation marker), soluble interleukin-2 receptor (sIL-2R), sIL-6R, IL-α, sIL-1R antagonist (sIL-1RA), tumor necrosis factor receptor 60kDa/80kDa (sTNFR60/R80) in 114 MDD and 133 BD patients, and 50 healthy controls...
September 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28809398/precision-medicine-for-suicidality-from-universality-to-subtypes-and-personalization
#8
A B Niculescu, H Le-Niculescu, D F Levey, P L Phalen, H L Dainton, K Roseberry, E M Niculescu, J O Niezer, A Williams, D L Graham, T J Jones, V Venugopal, A Ballew, M Yard, T Gelbart, S M Kurian, A Shekhar, N J Schork, G E Sandusky, D R Salomon
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identification of individuals at risk, ways of monitoring response to treatments and novel preventive therapeutics need to be discovered, employed and widely deployed. We sought to investigate whether blood gene expression biomarkers for suicide (that is, a 'liquid biopsy' approach) can be identified that are more universal in nature, working across psychiatric diagnoses and genders, using larger cohorts than in previous studies...
September 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28795995/toxic-myocarditis-caused-by-acetaminophen-in-a-multidrug-overdose
#9
Maxime Gosselin, Yann Dazé, Pascal Mireault, Marie Crahes
We report the case of an 18-year-old woman with personality disorders who was hospitalized a few hours after suicidal ingestion of acetaminophen, quetiapine, acetylsalicylic acid, and ethanol. Twelve hours after admission, severe liver damage was evident, but the patient was stable and awaiting hepatic transplantation. Electrolytes were successfully controlled. The condition of the liver stabilized. Cardiac biomarkers then deteriorated unexpectedly. Localized ST-segment elevations were noted on electrocardiogram, but angiography ruled out myocardial infarction...
December 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28783935/the-relationship-between-ghrelin-and-copeptin-levels-and-anxiety-and-depression-levels-in-suicide-attempts
#10
Metin Atescelik, Mustafa Yilmaz, Sevda Korkmaz, Mehmet Cagri Goktekin, Mehtap Gurger, Nevin Ilhan
Objective: It was aimed to detect acylated ghrelin (AG), unacylated ghrelin (UG) and copeptin levels in patients with suicide attempts and to determine if these biomarkers are risk factors for suicide attempts. Methods: Serum copeptin, AG and GU levels were screened in 128 patients who were admitted to emergency department with suicide attempts and 59 healthy controls. Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) were applied simultaneously, and the data were compared statistically...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28771381/psychometric-properties-and-factor-structures-of-the-korean-version-of-children-s-depression-rating-scale-revised
#11
Kyoung-Min Kim, Sojeong Nam, Jae-Won Choi, A-Hyun Jung, Soon-Beom Hong, Jun Won Kim, Soo Yeon Kim, Eunji Kim, Jae-Won Kim
OBJECTIVE: The Children's Depression Rating Scale-Revised (CDRS-R) is a valid instrument for the assessment of depressive symptoms in youth, but this measure is yet to be validated in Korea. Thus, the present study aimed to evaluate the validity of the Korean version of the CDRS-R and to determine its factor structures. METHODS: This study included 66 youths between 12 and 17 years of age who participated as part of an ongoing study investigating biomarkers of the antidepressant response and suicidal events in depressed youth...
August 3, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28757322/considerations-on-nonclinical-approaches-to-modeling-risk-factors-of-suicidal-ideation-and-behavior
#12
S M G Goody, K E Cannon, M Liu, M J Kallman, J P Martinolle, L Mazelin-Winum, A Giarola, P Ardayfio, J A Moyer, G Teuns, T J Hudzik
Given the serious nature of suicidal ideation and behavior (SIB) and the possibility of treatment-emergent SIB, pharmaceutical companies are now applying more proactive approaches in clinical trials and are considering the value of nonclinical models to predict SIB. The current review summarizes nonclinical approaches to modeling three common risk factors associated with SIB: aggression, impulsivity, and anhedonia. For each risk factor, a general description, advantages and disadvantages, species considerations, nonclinical to clinical translation, and pharmacological validation with respect to treatments associated with SIB are summarized...
July 27, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28753580/gnp-gapdh1-22-nanovaccines-prevent-neonatal-listeriosis-by-blocking-microglial-apoptosis-and-bacterial-dissemination
#13
Ricardo Calderon-Gonzalez, Elisabet Frande-Cabanes, Hector Teran-Navarro, José María Marimon, Javier Freire, David Salcines-Cuevas, M Carmen Fariñas, Claudia Gonzalez-Rico, Marco Marradi, Isabel Garcia, Mirian Alkorta-Gurrutxaga, Aida San Nicolas-Gomez, Ana Castañeda-San Pedro, Sonsoles Yañez-Diaz, Soledad Penades, Carmen Punzon, Javier Gomez-Roman, Fernando Rivera, Manuel Fresno, Carmen Alvarez-Dominguez
Clinical cases of neonatal listeriosis are associated with brain disease and fetal loss due to complications in early or late pregnancy, which suggests that microglial function is altered. This is believed to be the first study to link microglial apoptosis with neonatal listeriosis and listeriosis-associated brain disease, and to propose a new nanovaccine formulation that reverses all effects of listeriosis and confers Listeria monocytogenes (LM)-specific immunity. We examined clinical cases of neonatal listeriosis in 2013-2015 and defined two useful prognostic immune biomarkers to design listeriosis vaccines: high anti-GAPDH1-22 titres and tumor necrosis factor (TNF)/interleukin (IL)-6 ratios...
July 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28692478/diagnosis-of-vitality-in-skin-wounds-in-the-ligature-marks-resulting-from-suicide-hanging
#14
Isabel Legaz Pérez, Maria Falcón, M Gimenez, F Martínez Diaz, M D Pérez-Cárceles, E Osuna, D Nuno-Vieira, A Luna
Ascertaining the vital origin of skin wounds is one of the most challenging problems in forensic pathology. The forensic literature describes biomarkers and methods for differentiating vital and postmortem wounds, although no clear conclusions have been reached. The aim of this study was to characterize human vital wounds by analyzing the concentrations of metallic ions and the expression of P-selectin and cathepsin D in skin wounds in the ligature marks in a cohort of suicidal hangings for which vitality was previously demonstrated...
September 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28682534/objectively-assessed-sleep-variability-as-an-acute-warning-sign-of-suicidal-ideation-in-a-longitudinal-evaluation-of-young-adults-at-high-suicide-risk
#15
Rebecca A Bernert, Melanie A Hom, Naomi G Iwata, Thomas E Joiner
OBJECTIVE: Young adults attempt suicide at disproportionately high rates relative to other groups and demonstrate high rates of sleep disturbance. No study has yet prospectively evaluated disturbed sleep as an acute indicator of risk using an objective index of sleep. We investigated objective and subjective parameters of disturbed sleep as a warning sign of suicidal ideation among young adults over an acute period. METHODS: A longitudinal study across a 21-day observation period and 3 time points...
June 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28682230/-genetics-and-epigenetics-of-suicidal-behaviors
#16
Emilie Olié, Philippe Courtet
With more than 10 000 deaths each year in France, suicide is a major public health problem. Despite many known risk factors, suicide prediction remains extremely difficult in daily clinical practice. The identification of biomarkers, including genetic and epigenetic factors, is needed in suicidology in order to better understand pathophysiology of such behaviors and to improve the screening of individuals at high suicidal risk. Numerous studies have reported candidate genes involved in serotonergic system, HPA axis and neurotrophic system...
2017: Biologie Aujourd'hui
https://www.readbyqxmd.com/read/28668716/replication-of-rs300774-a-genetic-biomarker-near-acp1-associated-with-suicide-attempts-in-patients-with-schizophrenia-relation-to-brain-cholesterol-biosynthesis
#17
Jiang Li, Akane Yoshikawa, Herbert Y Meltzer
The aim of this study was to determine if three biomarkers for suicide attempts previously identified and replicated in a genome-wide association (GWAS) study of bipolar disorder (BD) suicide attempters also predicted suicide attempts in patients prospectively diagnosed with schizophrenia (SCZ) or schizoaffective disorder (SAD). 162 genetically-verified Caucasian patients with SCZ or SAD were phenotyped for presence (45.7%) or absence of a lifetime suicide attempt. Three single nucleotide polymorphisms (SNPs) were genotyped or partially imputed from a GWAS dataset...
June 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28645967/the-bipolar-illness-onset-study-research-protocol-for-the-bio-cohort-study
#18
Lars Vedel Kessing, Klaus Munkholm, Maria Faurholt-Jepsen, Kamilla Woznica Miskowiak, Lars Bo Nielsen, Ruth Frikke-Schmidt, Claus Ekstrøm, Ole Winther, Bente Klarlund Pedersen, Henrik Enghusen Poulsen, Roger S McIntyre, Flavio Kapczinski, Wagner F Gattaz, Jakob Bardram, Mads Frost, Oscar Mayora, Gitte Moos Knudsen, Mary Phillips, Maj Vinberg
INTRODUCTION: Bipolar disorder is an often disabling mental illness with a lifetime prevalence of 1%-2%, a high risk of recurrence of manic and depressive episodes, a lifelong elevated risk of suicide and a substantial heritability. The course of illness is frequently characterised by progressive shortening of interepisode intervals with each recurrence and increasing cognitive dysfunction in a subset of individuals with this condition. Clinically, diagnostic boundaries between bipolar disorder and other psychiatric disorders such as unipolar depression are unclear although pharmacological and psychological treatment strategies differ substantially...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28638711/decrease-in-brain-derived-neurotrophic-factor-at-plasma-level-but-not-in-serum-concentrations-in-suicide-behavior-a%C3%A2-systematic-review-and-meta-analysis
#19
Marisol Salas-Magaña, Carlos A Tovilla-Zárate, Thelma B González-Castro, Isela E Juárez-Rojop, María L López-Narváez, José M Rodríguez-Pérez, Julián Ramírez Bello
INTRODUCTION: Suicide is known as a major health concern worldwide. There is evidence for the role of brain-derived neurotrophic factor (BDNF) in suicide behavior. Therefore, this factor has been proposed as a biomarker for suicide behavior. Clinical studies have measured BDNF concentrations at central and peripheral levels. As a consequence, the aim of this study was to assess BDNF levels in blood plasma and serum to see whether there is a difference in concentrations in patients with suicide behavior when compared to those in controls, using a meta-analysis approach...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28636217/research-on-potential-biomarker-correlates-for-suicidal-behavior-a-review
#20
REVIEW
Sangha Kim, Kyoung-Uk Lee
Suicide is a world health priority. Studies over the last few decades have revealed the complexity underlying the neurobiological mechanisms of suicide. Researchers have found dysregulations in the serotonergic system, the stress system, neural plasticity, lipid metabolism, and cell signaling pathways in relation to suicidal behaviors. These findings have provided more insight into the final path leading to suicide, at which medical intervention should be applied to prevent the action. However, because these molecular mechanisms have been implicated in both depression and suicide, the specificity of the mechanisms has been obscured...
June 21, 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
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