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https://www.readbyqxmd.com/read/28201930/electroencephalographic-correlates-of-suicidal-ideation-in-the-theta-band
#1
Sang Min Lee, Kuk-In Jang, Jeong-Ho Chae
Previous studies have indicated that the abnormalities of brain activity are associated with suicidal behavior. However, few studies have explored neurophysiologic biomarkers of suicidal ideation (SI) in healthy subjects. Here, we studied alterations of theta quantitative EEG (QEEG) in frontal regions associated with SI in young healthy subjects. Resting QEEG data were recorded from 90 young healthy subjects. The subjects were divided into two group based on Scale for Suicidal Ideation (SSI) scores: a high SSI group (n = 33) and a low SSI group (n = 57)...
February 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28188894/emerging-rna-editing-biomarkers-will-foster-drug-development
#2
REVIEW
Siem van der Laan, Nicolas Salvetat, Dinah Weissmann, Franck Molina
Unanticipated adverse drug reactions (ADRs) on the central nervous system are a major cause of clinical attrition and market withdrawal. Current practices for their prospective assessment still lean on extensive analysis of rodent behaviour despite their highly controversial predictive value. Human-derived in vitro models that objectively quantify mechanism-related biomarkers can greatly contribute to better ADR prediction at early developmental stages. Adenosine-to-inosine RNA editing constitutes a physiological cellular process that translates environmental cues by regulating protein function at the synaptic level in health and disease...
February 7, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28183031/threat-related-amygdala-activity-is-associated-with-peripheral-crp-concentrations-in-men-but-not-women
#3
Johnna R Swartz, Aric A Prather, Ahmad R Hariri
Increased levels of peripheral inflammatory markers, including C-Reactive Protein (CRP), are associated with increased risk for depression, anxiety, and suicidality. The brain mechanisms that may underlie the association between peripheral inflammation and internalizing problems remain to be determined. The present study examines associations between peripheral CRP concentrations and threat-related amygdala activity, a neural biomarker of depression and anxiety risk, in a sample of 172 young adult undergraduate students...
January 25, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28135675/blunted-hpa-axis-activity-prior-to-suicide-attempt-and-increased-inflammation-in-attempters
#4
Nadine M Melhem, Sara Munroe, Anna Marsland, Katarina Gray, David Brent, Giovanna Porta, Antoine Douaihy, Mark L Laudenslager, Frank DePietro, Rasim Diler, Henry Driscoll, Priya Gopalan
BACKGROUND: Hypothalamic-Pituitary-Adrenal (HPA) axis dysregulation is associated with increased risk for suicidal behavior. However, it is not clear whether such dysregulation exists prior to or is a consequence of attempt. Studies also show an activation of inflammatory responses in suicidal behavior but often combine attempters with those with ideation. METHODS: The sample consisted of psychiatric inpatients, aged 15-30 years, admitted for suicide attempt (SA, n=38), inpatients admitted for suicidal ideation with no prior history of attempts (SI, n=40), and healthy controls (n=37)...
January 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28001286/charting-the-course-of-electroconvulsive-therapy-where-have-we-been-and-where-are-we-headed
#5
Peter B Rosenquist, W Vaughn McCall, Nagy Youssef
Electroconvulsive therapy (ECT) is one of the oldest and best treatments for severe mental illness. A safe and highly effective option for treatment-resistant mood disorders, ECT can be a lifesaving treatment for people suffering from catatonia and acute suicidality. Less recognized are the benefits of ECT in the treatment of primary psychotic disorders, Parkinson's disease, and status epilepticus. Evidence from multisite clinical trials in the past decade shows an evolving standard for the delivery of ECT to achieve and maintain remission and quality of life...
December 1, 2016: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/27931880/predictive-diagnosis-of-major-depression-using-nmr-based-metabolomics-and-least-squares-support-vector-machine
#6
Hong Zheng, Peng Zheng, Liangcai Zhao, Jianmin Jia, Shengli Tang, Pengtao Xu, Peng Xie, Hongchang Gao
BACKGROUND: Major depressive (MD) disorder is a serious psychiatric disorder that can result in suicidal behavior if not treated. The MD diagnosis using a standardized instrument instead of a structured interview will be advantageous for treatment and management of the MD, but so far no such technique exists. We developed an integrated analytical method of NMR-based metabolomics and least squares-support vector machine (LS-SVM) for predictive diagnosis of the MD. METHODS: The metabolite profiles in clinical plasma samples obtained from 72 depressive patients and 54 healthy subjects were analyzed by NMR spectroscopy...
January 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27876651/ventral-striatum-functional-connectivity-during-rewards-and-losses-and-symptomatology-in-depressed-patients
#7
Karina Quevedo, Rowena Ng, Hannah Scott, Srivastava Kodavaganti, Garry Smyda, Vaibhav Diwadkar, Mary Phillips
BACKGROUND: The ventral striatum (VS) and striatal network supports goal motivated behavior. Identifying how depressed patients differ in their striatal network during the processing of emotionally salient events is a step towards uncovering biomarkers for diagnosis and treatment. METHODS: 38 depressed and 30 healthy adults completed a task that examined brain activation to the anticipation and receipt of monetary rewards and losses. Data were collected using a 3T Siemens Trio scanner...
November 19, 2016: Biological Psychology
https://www.readbyqxmd.com/read/27873290/aims-and-structure-of-the-german-research-consortium-bipolife-for-the-study-of-bipolar-disorder
#8
REVIEW
Philipp S Ritter, Felix Bermpohl, Oliver Gruber, Martin Hautzinger, Andreas Jansen, Georg Juckel, Tilo Kircher, Martin Lambert, Christoph Mulert, Andrea Pfennig, Andreas Reif, Otto Rienhoff, Thomas G Schulze, Emanuel Severus, Thomas Stamm, Michael Bauer
BACKGROUND: Bipolar disorder is a severe and heterogeneous mental disorder. Despite great advances in neuroscience over the past decades, the precise causative mechanisms at the transmitter, cellular or network level have so far not been unraveled. As a result, individual treatment decisions cannot be tailor-made and the uncertain prognosis is based on clinical characteristics alone. Although a subpopulation of patients have an excellent response to pharmacological monotherapy, other subpopulations have been less well served by the medical system and therefore require more focused attention...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27836463/understanding-epigenetic-architecture-of-suicide-neurobiology-a-critical-perspective
#9
REVIEW
Bhaskar Roy, Yogesh Dwivedi
Current understanding of environmental cross-talk with genetic makeup is found to be mediated through an epigenetic interface which is associated with prominent reversible and heritable changes at gene expression level. Recent emergence of epigenetic modulation in shaping the genetic information has become a key regulatory factor in answering the underlying complexities associated with several mental disorders. A comprehensive understanding of the pertinent changes in the epigenetic makeup of suicide phenotype exhibits a characteristic signature with the possibility of using it as a biomarker to help predict the risk factors associated with suicide...
January 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27822318/discovery-and-replication-of-a-peripheral-tissue-dna-methylation-biosignature-to-augment-a-suicide-prediction-model
#10
Makena L Clive, Marco P Boks, Christiaan H Vinkers, Lauren M Osborne, Jennifer L Payne, Kerry J Ressler, Alicia K Smith, Holly C Wilcox, Zachary Kaminsky
BACKGROUND: Suicide is the second leading cause of death among adolescents in the USA, and rates are rising. Methods to identify individuals at risk are essential for implementing prevention strategies, and the development of a biomarker can potentially improve prediction of suicidal behaviors. Prediction of our previously reported SKA2 biomarker for suicide and PTSD is substantially improved by questionnaires assessing perceived stress or anxiety and is therefore reliant on psychological assessment...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27810712/sleep-architecture-parameters-as-a-putative-biomarker-of-suicidal-ideation-in-treatment-resistant-depression
#11
Rebecca A Bernert, David A Luckenbaugh, Wallace C Duncan, Naomi G Iwata, Elizabeth D Ballard, Carlos A Zarate
BACKGROUND: Disturbed sleep may confer risk for suicidal behaviors. Polysomnographic (PSG) sleep parameters have not been systematically evaluated in association with suicidal ideation (SI) among individuals with treatment-resistant depression (TRD). METHODS: This secondary data analysis included 54 TRD individuals (N=30 with major depressive disorder (MDD) and N=24 with bipolar depression (BD)). PSG sleep parameters included Sleep Efficiency (SE), Total Sleep Time (TST), Wakefulness After Sleep Onset (WASO), REM percent/latency, and non-REM (NREM) Sleep Stages 1-4...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27748930/mirnas-and-their-role-in-the-correlation-between-schizophrenia-and-cancer-review
#12
E Rizos, N Siafakas, E Skourti, C Papageorgiou, J Tsoporis, T H Parker, D I Christodoulou, D A Spandidos, E Katsantoni, V Zoumpourlis
Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is conversely characterized by an increase in appropriate molecular signaling that stimulates uncontrolled cell proliferation. The rather low risk of developing Ca in patients suffering from SZ is a hypothesis that is still under debate...
December 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27660275/associations-of-serum-cytokine-receptor-levels-with-melancholia-staging-of-illness-depressive-and-manic-phases-and-severity-of-depression-in-bipolar-disorder
#13
Marcin Siwek, Magdalena Sowa-Kućma, Krzysztof Styczeń, Paulina Misztak, Rafał J Nowak, Bernadeta Szewczyk, Dominika Dudek, Janusz K Rybakowski, Gabriel Nowak, Michael Maes
To examine cytokine receptor biomarkers in bipolar disorder (BD), we recruited 133 well-phenotyped BD patients and 50 normal controls and measured serum levels of soluble interleukin 1 receptor antagonist (sIL-1RA), soluble interleukin-2 receptor (sIL-2R), sIL-6R, and tumor necrosis factor receptor 60 and 80 kDa (sTNFR60/80). sIL-1RA and sTNFR80 are significantly higher in BD than in controls and sTNFR80 and higher in melancholic than in non-melancholic patients and controls. Kapczinski's stages 3 + 4 are characterized by lowered sIL-2R and increased sTNFR80 levels...
September 23, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27605454/the-extrinsic-coagulation-pathway-a-biomarker-for-suicidal-behavior-in-major-depressive-disorder
#14
Yongtao Yang, Jin Chen, Chengyu Liu, Liang Fang, Zhao Liu, Jing Guo, Ke Cheng, Chanjuan Zhou, Yuan Zhan, Narayan D Melgiri, Liang Zhang, Jiaju Zhong, Jianjun Chen, Chenglong Rao, Peng Xie
Although an association between major depressive disorder (MDD) and suicide exists, most depressed patients never attempt suicide. An improved understanding of the factors contributing to suicidal risk in MDD can provide direction for suicide predictor development. In MDD suicide attempters (MDD-SA), MDD non-attempters (MDD-NA), and healthy controls (HC) (n = 12 each group), complementary plasma proteomics identified 45 differential proteins mapped to coagulation and inflammation, 25 of which underwent Western blotting...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27521810/design-rationale-and-baseline-characteristics-of-the-randomized-double-blind-phase-ii-clinical-trial-of-ibudilast-in-progressive-multiple-sclerosis
#15
Robert J Fox, Christopher S Coffey, Merit E Cudkowicz, Trevis Gleason, Andrew Goodman, Eric C Klawiter, Kazuko Matsuda, Michelle McGovern, Robin Conwit, Robert Naismith, Akshata Ashokkumar, Robert Bermel, Dixie Ecklund, Maxine Koepp, Jeffrey Long, Sneha Natarajan, Srividya Ramachandran, Thomai Skaramagas, Brenda Thornell, Jon Yankey, Mark Agius, Khurram Bashir, Bruce Cohen, Patricia Coyle, Silvia Delgado, Dana Dewitt, Angela Flores, Barbara Giesser, Myla Goldman, Burk Jubelt, Neil Lava, Sharon Lynch, Augusto Miravalle, Harold Moses, Daniel Ontaneda, Jai Perumal, Michael Racke, Pavle Repovic, Claire Riley, Christopher Severson, Shlomo Shinnar, Valerie Suski, Bianca Weinstock-Gutman, Vijayshree Yadav, Aram Zabeti
BACKGROUND: Primary and secondary progressive multiple sclerosis (MS), collectively called progressive multiple sclerosis (PMS), is characterized by gradual progression of disability. The current anti-inflammatory treatments for MS have little or no efficacy in PMS in the absence of obvious active inflammation. Optimal biomarkers for phase II PMS trials is unknown. Ibudilast is an inhibitor of macrophage migration inhibitor factor and phosphodiesterases-4 and -10 and exhibits possible neuroprotective properties...
September 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27503048/use-of-gene-expression-biomarkers-to-predict-suicidality
#16
Ries Simons
Since the tragic accident of Germanwings flight 4U9525, there has been discussion about methods to identify and prevent suicidality in pilots. Neurogenetic scientists claim that biomarker tests for suicidality as part of healthcare assessments may lead to early identification of suicidal behavior. In this commentary the value of these gene expression biomarkers for aeromedical purposes is evaluated based on relevant literature. It is concluded that the currently identified biomarkers for suicidality need thorough validation before they can be used...
July 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/27463606/positron-emission-tomographic-imaging-of-the-serotonergic-system-and-prediction-of-risk-and-lethality-of-future-suicidal-behavior
#17
Maria A Oquendo, Hanga Galfalvy, Gregory M Sullivan, Jeffrey M Miller, Matthew M Milak, M Elizabeth Sublette, Sebastian Cisneros-Trujillo, Ainsley K Burke, Ramin V Parsey, J John Mann
Importance: Biomarkers that predict suicidal behavior, especially highly lethal behavior, are urgently needed. In cross-sectional studies, individuals with depression who attempt suicide have lower midbrain serotonin transporter binding potential compared with those who do not attempt suicide, and higher serotonin1A binding potential in the raphe nuclei (RN) is associated with greater lethality of past suicide attempts and suicidal intent and ideation. Objectives: To determine whether serotonin transporter binding potential in the lower midbrain predicts future suicide attempts and whether higher RN serotonin1A binding potential predicts future suicidal ideation and intent and lethality of future suicide attempts...
October 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27411502/a-study-on-paracetamol-cardiotoxicity
#18
Udaya Ralapanawa, Kushalee Poornima Jayawickreme, Ekanayake Mudiyanselage Madhushanka Ekanayake, A M S Dhammika Menike Dissanayake
BACKGROUND: Sri Lanka has a high suicide rate, with more than 40 % of poisoning admissions due to overdose of drugs with Paracetamol being the commonest. Data regarding cardiotoxicity to paracetamol is very minimal though hepatotoxicity following poisoning is well studied. Paracetamol cardiotoxicity has rarely been clinically significant and may have well been overlooked. The possibility that paracetamol overdose might be directly cardiotoxic has been the subject of a few reports. Unexplained deaths and electrocardiographic changes associated with paracetamol poisoning have also been reported in which cardiac origin cannot be clearly ruled out...
2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27378071/startle-amplitude-during-unpleasant-pictures-is-greater-in-veterans-with-a-history-of-multiple-suicide-attempts-and-predicts-a-future-suicide-attempt
#19
Erin A Hazlett, Nicholas J Blair, Nicolas Fernandez, Kathryn Mascitelli, M Mercedes Perez-Rodriguez, Antonia S New, Raymond R Goetz, Marianne Goodman
UNLABELLED: Recent studies demonstrate that veterans exhibit higher suicide risk compared with the general U.S. POPULATION: A prior suicide attempt is a well-documented predictor of suicide death. Despite increased attention to clinical risk factors of suicide and efforts to develop psychosocial interventions to reduce suicide risk, the underlying biological factors that confer this risk are not well understood. This study examined affect-modulated startle (AMS) during a series of intermixed unpleasant, neutral, and pleasant pictures in a sample of 108 demographically-matched veterans at low (passive ideators: n = 26) and high risk (active ideators: n = 29; single attempters: n = 28; and multiple attempters: n = 25) for suicide based on the Columbia Suicide Severity Rating Scale...
October 2016: Psychophysiology
https://www.readbyqxmd.com/read/27352637/the-role-of-rumination-in-illness-trajectories-in-youth-linking-trans-diagnostic-processes-with-clinical-staging-models
#20
A B Grierson, I B Hickie, S L Naismith, J Scott
Research in developmental psychopathology and clinical staging models has increasingly sought to identify trans-diagnostic biomarkers or neurocognitive deficits that may play a role in the onset and trajectory of mental disorders and could represent modifiable treatment targets. Less attention has been directed at the potential role of cognitive-emotional regulation processes such as ruminative response style. Maladaptive rumination (toxic brooding) is a known mediator of the association between gender and internalizing disorders in adolescents and is increased in individuals with a history of early adversity...
September 2016: Psychological Medicine
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