keyword
MENU ▼
Read by QxMD icon Read
search

biomarker & depression

keyword
https://www.readbyqxmd.com/read/27903103/electrocortical-responses-to-rewards-and-emotional-stimuli-as-biomarkers-of-risk-for-depressive-disorders
#1
Gerard E Bruder
No abstract text is available yet for this article.
December 1, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27900617/new-and-evolving-concepts-regarding-the-prognosis-and-treatment-of-cardiac-amyloidosis
#2
REVIEW
Stefano Perlini, Roberta Mussinelli, Francesco Salinaro
Systemic amyloidoses are rare and proteiform diseases, caused by extracellular accumulation of insoluble misfolded fibrillar proteins. Prognosis is dictated by cardiac involvement, which is especially frequent in light chain (AL) and in transthyretin variants (ATTR, both mutated, (ATTRm), and wild-type, (ATTRwt)). Recently, ATTRwt has emerged as a potentially relevant cause of a heart failure with preserved ejection fraction (HFpEF). Cardiac amyloidosis is an archetypal example of restrictive cardiomyopathy, with signs and symptoms of global heart failure and diastolic dysfunction...
November 29, 2016: Current Heart Failure Reports
https://www.readbyqxmd.com/read/27889469/changes-in-neural-circuitry-associated-with-depression-at-pre-clinical-pre-motor-and-early-motor-phases-of-parkinson-s-disease
#3
REVIEW
Janina Borgonovo, Camilo Allende-Castro, Almudena Laliena, Néstor Guerrero, Hernán Silva, Miguel L Concha
Although Parkinson's Disease (PD) is mostly considered a motor disorder, it can present at early stages as a non-motor pathology. Among the non-motor clinical manifestations, depression shows a high prevalence and can be one of the first clinical signs to appear, even a decade before the onset of motor symptoms. Here, we review the evidence of early dysfunction in neural circuitry associated with depression in the context of PD, focusing on pre-clinical, pre-motor and early motor phases of the disease. In the pre-clinical phase, structural and functional changes in the substantia nigra, basal ganglia and limbic structures are already observed...
November 21, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27885309/transcranial-direct-current-stimulation-use-in-the-treatment-of-neuropsychiatric-disorders-a-brief-review
#4
Sarah M Szymkowicz, Molly E McLaren, Uma Suryadevara, Adam J Woods
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has grown in popularity over the past two decades as an alternative treatment option for various neuropsychiatric disorders. tDCS modulates cortical excitability through the application of a weak direct current to the scalp via electrodes placed over cortical regions of interest. It has been shown to be a promising and relatively safe treatment tool with few adverse events. In this article, we will briefly review the efficacy of tDCS in depression, bipolar disorder, schizophrenia, and obsessive-compulsive disorder...
November 2016: Psychiatric Annals
https://www.readbyqxmd.com/read/27878359/long-noncoding-rna-gas5-inhibits-malignant-proliferation-and-chemotherapy-resistance-to-doxorubicin-in-bladder-transitional-cell-carcinoma
#5
Hui Zhang, Yan Guo, Yongsheng Song, Chao Shang
PURPOSE: Bladder cancer is the most general malignant cancer in genitourinary system, more than 90% of BCs are bladder transitional cell carcinomas (BTCC). This study aimed to investigate the clinical significance of growth arrest-specific 5 (GAS5) gene and its regulatory effects of malignant proliferation and chemotherapy resistance to doxorubicin in BTCC cells. METHODS: The expression of GAS5 was detected by quantitative real-time PCR. Statistical analysis was used to determine the relationship between GAS5 expression and clinical features and the prognostic value of GAS5 for disease free survival...
November 22, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27876651/ventral-striatum-functional-connectivity-during-rewards-and-losses-and-symptomatology-in-depressed-patients
#6
Karina Quevedo, Rowena Ng, Hannah Scott, Srivastava Kodavaganti, Garry Smyda, Vaibhav Diwadkar, Mary Phillips
BACKGROUND: The ventral striatum (VS) and striatal network supports goal motivated behavior. Identifying how depressed patients differ in their striatal network during the processing of emotionally salient events is a step towards uncovering biomarkers for diagnosis and treatment. METHODS: 38 depressed and 30 healthy adults completed a task that examined brain activation to the anticipation and receipt of monetary rewards and losses. Data were collected using a 3T Siemens Trio scanner...
November 19, 2016: Biological Psychology
https://www.readbyqxmd.com/read/27870451/preclinical-sex-differences-in-depression-and-antidepressant-response-implications-for-clinical-research
#7
REVIEW
Nikolaos Kokras, Christina Dalla
Women suffer from depression and anxiety disorders more often than men, and as a result they receive antidepressants to a greater extent. Sex differences in antidepressant response in humans have been modestly studied, and results have been controversial. At the same time, preclinical studies on animal models of depression and antidepressant response have provided insights with regard to sex differences that could be useful for the design and interpretation of future clinical trials. This Mini-Review discusses such sex-differentiated findings with regard to the presentation of depression, endophenotypes, and antidepressant response...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27870414/sex-differences-in-neural-responses-to-subliminal-sad-and-happy-faces-in-healthy-individuals-implications-for-depression
#8
Teresa A Victor, Wayne C Drevets, Masaya Misaki, Jerzy Bodurka, Jonathan Savitz
Twice as many women as men suffer from mood and anxiety disorders, yet the biological underpinnings of this phenomenon have been understudied and remain unclear. We and others have shown that the hemodynamic response to subliminally presented sad or happy faces during functional MRI (fMRI) is a robust biomarker for the attentional bias toward negative information classically observed in major depression. Here we used fMRI to compare the performance of healthy females (n = 28) and healthy males (n = 28) on a backward masking task using a fast event-related design with gradient-recalled, echoplanar imaging with sensitivity encoding...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27867936/effects-of-lithium-monotherapy-for-bipolar-disorder-on-gene-expression-in-peripheral-lymphocytes
#9
Amit Anand, Jeanette N McClintick, Jill Murrell, Harish Karne, John I Nurnberger, Howard J Edenberg
BACKGROUND: This study investigated the effect of lithium monotherapy on peripheral lymphocyte gene expression in bipolar disorder (BD). METHOD: Twenty-two medication-free bipolar subjects (11 hypomanic, 11 depressed) were started on lithium monotherapy. Closely matched healthy subjects (n = 15) were included as controls but did not receive treatment. Blood RNA samples were collected at baseline and after 2 and 8 weeks of treatment. RNA expression was measured using the Affymetrix GeneChip® Human Gene 1...
October 2016: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/27866858/clinical-variables-and-biomarkers-in-prediction-of-cognitive-impairment-in-patients-with-newly-diagnosed-parkinson-s-disease-a-cohort-study
#10
Anette Schrag, Uzma Faisal Siddiqui, Zacharias Anastasiou, Daniel Weintraub, Jonathan M Schott
BACKGROUND: Parkinson's disease is associated with an increased incidence of cognitive impairment and dementia. Predicting who is at risk of cognitive decline early in the disease course has implications for clinical prognosis and for stratification of participants in clinical trials. We assessed the use of clinical information and biomarkers as predictive factors for cognitive decline in patients with newly diagnosed Parkinson's disease. METHODS: The Parkinson's Progression Markers Initiative (PPMI) study is a cohort study in patients with newly diagnosed Parkinson's disease...
November 17, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27866044/alternative-splicing-of-smpd1-coding-for-acid-sphingomyelinase-in-major-depression
#11
Cosima Rhein, Martin Reichel, Marcel Kramer, Andrea Rotter, Bernd Lenz, Christiane Mühle, Erich Gulbins, Johannes Kornhuber
BACKGROUND: Major depressive disorder (MDD) is a psychiatric disorder characterized by key symptoms that include depressed mood and a loss of interest and pleasure. A recently developed pathogenic model of MDD involves disturbed neurogenesis in the hippocampus, where the acid sphingomyelinase (ASM)/ceramide system plays an important role and is proposed as a molecular target for antidepressant action. Because alternative splicing of SMPD1 mRNA, coding for ASM, is relevant for the regulation of ASM enzymatic activity, we investigated the frequency of alternatively spliced ASM isoforms in peripheral blood cells of MDD patients versus healthy controls...
September 28, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27864783/mir-26a-5p-suppresses-tumor-metastasis-by-regulating-emt-and-is-associated-with-prognosis-in-hcc
#12
L Chang, K Li, T Guo
OBJECTIVE: To determine the role of miR-26a-5p in tumor invasion and metastasis in hepatocellular carcinoma (HCC). METHODS: We evaluated miR-26a-5p expression in HCC tissues by quantitative PCR and then analyzed its clinical significance using a Cox regression model. Transwell and nude mouse models were used to examine tumor metastasis in vitro and in vivo, respectively. The relationship between miR-26a-5p and epithelial-mesenchymal transition was also investigated by q-PCR and western blot...
November 18, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27863707/outcomes-in-childhood-following-therapeutic-hypothermia-for-neonatal-hypoxic-ischemic-encephalopathy-hie
#13
REVIEW
Girija Natarajan, Athina Pappas, Seetha Shankaran
In this article, we review the childhood outcomes of neonates with birth depression and/or hypoxic-ischemic encephalopathy. The outcomes of these children prior to the era of hypothermia for neuroprotection will first be summarized, followed by discussion of results from randomized controlled trials of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy. The predictors of outcome in childhood following neonatal HIE using clinical and imaging biomarkers following hypothermia therapy will be described...
November 15, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27862222/exposure-to-chlorantraniliprole-affects-the-energy-metabolism-of-the-caddisfly-sericostoma-vittatum
#14
Andreia C M Rodrigues, Carlos Gravato, Carla Quintaneiro, Maria D Bordalo, Oksana Golovko, Vladimír Žlábek, Carlos Barata, Amadeu M V M Soares, João L T Pestana
Caddisflies have been included in ecotoxicological studies due to their sensitivity and ecological relevance. The present study aimed to assess the sub-lethal effects of an anthranilic diamide insecticide, chlorantraniliprole (CAP), to Sericostoma vittatum. CAP, used worldwide, is a persistent compound that has been found in surface waters at concentrations from 0.1 to 9.7 µg/L. CAP targets the ryanodine receptors and this ecotoxicological assessment was focused on biomarkers related to neurotransmission, biotransformation, oxidative stress damage and on energy processing related endpoints (feeding, energy reserves and cellular metabolism)...
November 10, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27856124/enhanced-molecular-aging-in-late-life-depression-the-senescent-associated-secretory-phenotype
#15
Breno Satler Diniz, Charles F Reynolds, Etienne Sibille, Chien-Wei Lin, George Tseng, Francis Lotrich, Howard J Aizenstein, Meryl A Butters
OBJECTIVE: This study aims to investigate whether a systemic molecular pattern associated with aging (senescent-associated secretory phenotype [SASP]) is elevated in adults with late-life depression (LLD), compared with never-depressed elderly comparison participants. DESIGN: Cross-sectional study. PARTICIPANTS: We included 111 older adults (80 with LLD and 31 comparison participants) in this study. MEASUREMENT: A panel of 22 SASP-related proteins was extracted from a previous multiplex protein panel performed in these participants...
August 31, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27855438/how-to-prevent-depression-current-directions-and-future-challenges-in-children-with-chronic-medical-conditions
#16
Anna Felnhofer, Oswald D Kothgassner, Claudia Klier
With its high rates of chronicity and concomitant economic costs to society, depression ranges among the most prevalent mental disorders. Several trials have succeeded in demonstrating the beneficial effects of early depression prevention programs for otherwise healthy children and adolescents. However, comparable programs for children and adolescents with a medical condition are still scarce. This paper discusses the situation of chronically ill children and adolescents who are at risk of developing comorbid depressive symptoms using the example of three conditions frequently encountered in pediatric psychosomatic medicine: diabetes, epilepsy and inflammatory bowel disease (IBD)...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27845778/identification-of-sex-specific-urinary-biomarkers-for-major-depressive-disorder-by-combined-application-of-nmr-and-gc-ms-based-metabonomics
#17
P Zheng, J-J Chen, C-J Zhou, L Zeng, K-W Li, L Sun, M-L Liu, D Zhu, Z-H Liang, P Xie
Women are more vulnerable to major depressive disorder (MDD) than men. However, molecular biomarkers of sex differences are limited. Here we combined gas chromatography-mass spectrometry (GC-MS)- and nuclear magnetic resonance (NMR)-based metabonomics to investigate sex differences of urinary metabolite markers in MDD, and further explore their potential of diagnosing MDD. Consequently, the metabolite signatures of women and men MDD subjects were significantly different from of that in their respective healthy controls (HCs)...
November 15, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27845776/proliferation-rates-and-gene-expression-profiles-in-human-lymphoblastoid-cell-lines-from-patients-with-depression-characterized-in-response-to-antidepressant-drug-therapy
#18
J Breitfeld, C Scholl, M Steffens, K Brandenburg, K Probst-Schendzielorz, O Efimkina, D Gurwitz, M Ising, F Holsboer, S Lucae, J C Stingl
The current therapy success of depressive disorders remains in need of improvement due to low response rates and a delay in symptomatic improvement. Reliable functional biomarkers would be necessary to predict the individual treatment outcome. On the basis of the neurotrophic hypothesis of antidepressant's action, effects of antidepressant drugs on proliferation may serve as tentative individual markers for treatment efficacy. We studied individual differences in antidepressant drug effects on cell proliferation and gene expression in lymphoblastoid cell lines (LCLs) derived from patients treated for depression with documented clinical treatment outcome...
November 15, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27844089/-biomarkers-for-dementia-and-other-neurodegenerative-diseases-current-developments
#19
J Wiltfang, P Lewczuk, M Otto
Cerebrospinal fluid-based neurochemical dementia diagnostics (CSF-NDD) support the early and differential diagnosis of dementia, most importantly the diagnosis of early or preclinical Alzheimer's dementia (AD). Meanwhile CSF-NDD are now recommended for improved exclusion and positive diagnostics of AD by the German national neuropsychiatry S3 dementia guidelines ( www.DGPPN.de ). Meta-analyses of independent international multicenter studies have shown that a combined CSF analysis of amyloid-beta 1-42 (Aβ 1-42, decreased), total tau proteins (increased) and phospho-tau proteins (increased) offers a sensitivity and specificity of 80-90 % for the early and differential diagnosis of AD (AD versus all other)...
November 14, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27833064/negativity-bias-for-sad-faces-in-depression-an-event-related-potential-study
#20
Qin Dai, Juanjuan Wei, Xiaorui Shu, Zhengzhi Feng
OBJECTIVE: Negativity bias in depression has been previously confirmed. However, mainly during a valence category task, it remains unclear how happy or unhappy individuals perceive emotional materials. Moreover, cerebral alteration measurements during a valence judgment task is lacking. The present study aimed to explore a valence judgment of a valence rating task, combined with event-related potential (ERP) recording. METHODS: Healthy controls, individuals with sub-clinical depression, and patients diagnosed with major depressive disorder (MDD) were recruited...
December 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
keyword
keyword
37855
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"