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biomarker & depression

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https://www.readbyqxmd.com/read/29665163/lowered-quality-of-life-in-mood-disorders-is-associated-with-increased-neuro-oxidative-stress-and-basal-thyroid-stimulating-hormone-levels-and-use-of-anticonvulsant-mood-stabilizers
#1
Caroline Sampaio Nunes, Michael Maes, Chutima Roomruangwong, Juliana Brum Moraes, Kamila Landucci Bonifacio, Heber Odebrecht Vargas, Decio Sabbatini Barbosa, George Anderson, Luiz Gustavo Piccoli de Melo, Stoyanov Drozdstoj, Estefania Moreira, André F Carvalho, Sandra Odebrecht Vargas Nunes
RATIONALE, AIMS: Major affective disorders including bipolar disorder (BD) and major depressive disorder (MDD) are associated with impaired health-related quality of life (HRQoL). Oxidative stress and subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro-oxidative biomarkers and thyroid-stimulating hormone (TSH) levels could predict HRQoL in BD and MDD. METHODS: This cross-sectional study enrolled 68 BD and 37 MDD patients and 66 healthy controls...
April 17, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29665048/a-neural-biomarker-the-error-related-negativity-predicts-the-first-onset-of-generalized-anxiety-disorder-in-a-large-sample-of-adolescent-females
#2
Alexandria Meyer, Brady Nelson, Greg Perlman, Daniel N Klein, Roman Kotov
OBJECTIVE: An increased neural response to making mistakes has emerged as a potential biomarker of anxiety across development. The error-related negativity (ERN) is an event-related potential elicited when people make mistakes on simple laboratory-based reaction time tasks that has been associated with risk for anxiety. This study examined whether the ERN prospectively predicted the first onset of generalized anxiety disorder (GAD) over 1.5 years in adolescent girls. METHODS: The sample included 457 girls between the ages of 13...
April 17, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29664942/dietary-cyanogen-exposure-and-early-child-neurodevelopment-an-observational-study-from-the-democratic-republic-of-congo
#3
Espérance Kashala-Abotnes, Marie-Thérèse Sombo, Daniel L Okitundu, Marcel Kunyu, Guy Bumoko Makila-Mabe, Thorkild Tylleskär, Alla Sikorskii, Jean-Pierre Banea, Dieudonné Mumba Ngoyi, Désiré Tshala-Katumbay, Michael J Boivin
BACKGROUND: Dietary cyanogen exposure from ingesting bitter (toxic) cassava as a main source of food in sub-Saharan Africa is related to neurological impairments in sub-Saharan Africa. We explored possible association with early child neurodevelopmental outcomes. METHODS: We undertook a cross-sectional neurodevelopmental assessment of 12-48 month-old children using the Mullen Scale of Early Learning (MSEL) and the Gensini Gavito Scale (GGS). We used the Hopkins Symptoms Checklist-10 (HSCL-10) and Goldberg Depression Anxiety Scale (GDAS) to screen for symptoms of maternal depression-anxiety...
2018: PloS One
https://www.readbyqxmd.com/read/29660911/the-effects-of-different-remote-ischemic-conditioning-on-ischemia-induced-failure-of-microvascular-circulation-in-humans
#4
Muzaffer Akkoca, Suzan Emel Usanmaz, Serhat Tokgöz, Cüneyt Köksoy, Emine Demirel-Yilmaz
BACKGROUND: Intermittent ischemia in remote tissues can be applied before ischemic injury, during ischemic injury or at the beginning of reperfusion of an index organ ischemia. The aim of this study was to investigate the effect of Remote Ischemic Conditioning (RIC) of the leg on changes in ischemia-induced the microvascular functions of the arm. MATERIAL AND METHODS: Ischemic microvascular injury was induced by arm ischemia (20 min) and reperfusion in healthy, nonsmoker, male volunteers (ischemia group-ISC, n: 9)...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660639/elevated-tumor-necrosis-factor-alpha-receptor-subtype-1-and-the-association-with-abnormal-brain-function-in-treatment-resistant-depression
#5
Mao-Hsuan Huang, Mu-Hong Chen, Pei-Chi Tu, Ya Mei Bai, Tung-Ping Su, Bang-Hung Yang, Ren-Shyan Liu, Cheng-Ta Li
BACKGROUND: Major depressive disorder (MDD) patients have shown elevated plasma levels of pro-inflammatory biomarkers compared to healthy controls. We hypothesized increased serum tumor necrosis factor-alpha receptor subtype 1 (TNF-α R1) is more associated with impaired brain function in patients with treatment-resistant depression (TRD) than those without TRD. METHODS: 34 MDD patients and 34 healthy subjects were recruited and we separated MDD patients to TRD group (n = 20) and non-TRD (n = 14) group...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29656497/altered-brain-function-in-persistent-postural-perceptual-dizziness-a-study-on-resting-state-functional-connectivity
#6
Jin-Ok Lee, Eek-Sung Lee, Ji-Soo Kim, Young-Beom Lee, Yong Jeong, Byung Se Choi, Jae-Hyoung Kim, Jeffrey P Staab
This study used resting state functional magnetic resonance imaging (rsfMRI) to investigate whole brain networks in patients with persistent postural perceptual dizziness (PPPD). We compared rsfMRI data from 38 patients with PPPD and 38 healthy controls using whole brain and region of interest analyses. We examined correlations among connectivity and clinical variables and tested the ability of a machine learning algorithm to classify subjects using rsfMRI results. Patients with PPPD showed: (a) increased connectivity of subcallosal cortex with left superior lateral occipital cortex and left middle frontal gyrus, (b) decreased connectivity of left hippocampus with bilateral central opercular cortices, left posterior opercular cortex, right insular cortex and cerebellum, and (c) decreased connectivity between right nucleus accumbens and anterior left temporal fusiform cortex...
April 15, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29626829/the-effects-of-adiposity-and-alcohol-use-disorder-on-adipokines-and-biomarkers-of-inflammation-in-depressed-patients
#7
Mari Archer, Onni Niemelä, Mari Hämäläinen, Eeva Moilanen, Esa Leinonen, Olli Kampman
Patients with depression and alcohol use disorder frequently present with elevated markers of inflammation. Adipose tissue may function as a source for inflammation, yet the interplay between adiposity, alcohol use and depression has remained unknown. We examined 242 patients, referred to treatment for depressive symptoms, and followed for a period of 6 months. The assessments included screening for alcohol use and measurements of body mass index, serum adiponectin, leptin, resistin, progranulin, hs-CRP, IL-6 and MCP-1 at baseline and after 6 months of treatment...
March 28, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29626340/neuroimmune-biomarkers-in-mental-illness
#8
James W Herron, Louis Nerurkar, Jonathan Cavanagh
Exploration of neuroimmune mechanisms is vital to the understanding of the pathogenesis and pathophysiology of mental disorders. Inflammatory and immune mechanisms are increasingly understood to underpin a number of neuropsychiatric disorders, with an ever-expanding evidence base drawn from basic science to large-scale epidemiological data. Unravelling of these mechanisms should lead to biomarker discovery and potential new avenues for therapeutics that modulate immunological mechanisms. Identification of neuroimmune biomarkers is vital to improving diagnosis, stratification and treatment of mental disorders...
April 7, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29626337/network-neuroscience-a-framework-for-developing-biomarkers-in-psychiatry
#9
David M Lydon-Staley, Danielle S Bassett
Psychiatric disorders are disturbances of cognitive and behavioral processes mediated by the brain. Emerging evidence suggests that accurate biomarkers for psychiatric disorders might benefit from incorporating information regarding multiple brain regions and their interactions with one another, rather than considering local perturbations in brain structure and function alone. Recent advances in the field of applied mathematics generally - and network science specifically - provide a language to capture the complexity of interacting brain regions, and the application of this language to fundamental questions in neuroscience forms the emerging field of network neuroscience...
April 7, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29623831/proteomics-approach-for-biomarker-research-in-major-depression-antidepressant-effects
#10
Tiao-Lai Huang, Li-Hua Lo
The proteomics approach is the new mantra in disease biomarker research in areas such as major depression (MD). Current protocols for investigating biomarkers in biological fluid often employ both immuno-based and non-immuno-based technologies. The immuno-based method is used normally in measuring well-known disease biomarkers, and commercial kits are often available. Immuno-based methods such as radio-immunoassay and enzyme-linked immunosorbent assay are sensitive and specific. However, tedious sample preparations such as filtration and centrifugation are required...
April 3, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29621722/ptsd-and-depressive-symptoms-are-linked-to-dheas-via-personality
#11
Danka Savic, Goran Knezevic, Gordana Matic, Svetozar Damjanovic
BACKGROUND: Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. METHOD: This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age...
March 27, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29615645/antidepressant-drug-specific-prediction-of-depression-treatment-outcomes-from-genetic-and-clinical-variables
#12
Raquel Iniesta, Karen Hodgson, Daniel Stahl, Karim Malki, Wolfgang Maier, Marcella Rietschel, Ole Mors, Joanna Hauser, Neven Henigsberg, Mojca Zvezdana Dernovsek, Daniel Souery, Richard Dobson, Katherine J Aitchison, Anne Farmer, Peter McGuffin, Cathryn M Lewis, Rudolf Uher
Individuals with depression differ substantially in their response to treatment with antidepressants. Specific predictors explain only a small proportion of these differences. To meaningfully predict who will respond to which antidepressant, it may be necessary to combine multiple biomarkers and clinical variables. Using statistical learning on common genetic variants and clinical information in a training sample of 280 individuals randomly allocated to 12-week treatment with antidepressants escitalopram or nortriptyline, we derived models to predict remission with each antidepressant drug...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614851/the-make-biomarker-discovery-for-enhancing-antidepressant-treatment-effect-and-response-study-design-and-methodology
#13
Hee-Ju Kang, Ju-Wan Kim, Seon-Young Kim, Sung-Wan Kim, Hee-Young Shin, Myung-Geun Shin, Jae-Min Kim
Objective: Depression is associated with a major disease burden, and many individuals suffer from depressive symptoms due to an insufficient response to ostensibly adequate antidepressant treatment. Therefore, it is important to identify reliable treatment response predictors for use in developing personalized treatment strategies. Methods: The MAKE Biomarker discovery for Enhancing anTidepressant Treatment Effect and Response (MAKE BETTER) study was performed to identify predictors of antidepressant response using a 2-year naturalistic prospective design...
April 5, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29614706/yoga-and-meditation-based-lifestyle-intervention-increases-neuroplasticity-and-reduces-severity-of-major-depressive-disorder-a-randomized-controlled-trial
#14
Madhuri R Tolahunase, Rajesh Sagar, Muneeb Faiq, Rima Dada
BACKGROUND: Current interventions for major depressive disorder (MDD) are suboptimal, and only one third respond to them on initial treatment. Neuroplasticity theories are the basis for several emerging treatments. Evidence on the impact of yoga, a well-known mind-body intervention, on neuroplasticity in MDD is limited. OBJECTIVES: To determine the effects of 12-week yoga- and meditation- based lifestyle intervention (YMLI) on depression severity and systemic biomarkers of neuroplasticity in adult MDD patients on routine drug treatment...
March 25, 2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29611101/the-compensatory-immune-regulatory-reflex-system-cirs-in-depression-and-bipolar-disorder
#15
REVIEW
Michael Maes, Andre F Carvalho
Here, we review a novel concept namely the compensatory immune-regulatory reflex system (CIRS) as applied to the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD). There is evidence that a substantial subset of individuals with MDD and BD exhibit an activation of the immune-inflammatory response system (IRS), as indicated by an increased production of macrophagic M1 and T helper (Th)-1 pro-inflammatory cytokines, interleukin (IL)-6 trans-signaling, positive acute phase proteins (APPs), and complement factors...
April 2, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29609189/changes-in-autonomic-tone-in-premature-infants-developing-necrotizing-enterocolitis
#16
Tareq Al-Shargabi, Daniel Reich, R B Govindan, Somya Shankar, Marina Metzler, Caitlin Cristante, Robert McCarter, Anthony D Sandler, Mariam Said, Adre du Plessis
BACKGROUND:  Necrotizing enterocolitis (NEC) is a complication of prematurity with a high mortality rate. Currently, there are no reliable biomarkers capable of identifying infants at risk for developing NEC. We sought to determine the autonomic nervous system antecedents of NEC in premature infants, using heart rate variability (HRV). MATERIALS AND METHODS:  HRV was quantified by retrieving archived electrocardiogram (EKG) data from 30 premature infants from 4 days prior, through 4 days after, the clinical NEC diagnosis...
April 2, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29609112/hair-cortisol-concentration-hcc-as-a-measure-for-prenatal-psychological-distress-a-systematic-review
#17
REVIEW
Paula Mustonen, Linnea Karlsson, Noora M Scheinin, Susanna Kortesluoma, Bárbara Coimbra, Ana João Rodrigues, Hasse Karlsson
Prenatal environment reportedly affects the programming of developmental trajectories in offspring and the modification of risks for later morbidity. Among the increasingly studied prenatal exposures are maternal psychological distress (PD) and altered maternal hypothalamus-pituitary-adrenal (HPA) axis functioning. Both prenatal PD and maternal short-term cortisol concentrations as markers for HPA axis activity have been linked to adverse child outcomes and it has been assumed that maternal PD affects the offspring partially via altered cortisol secretion patterns...
March 27, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29608925/transdiagnostic-and-diagnosis-specific-dynamic-functional-connectivity-anchored-in-the-right-anterior-insula-in-major-depressive-disorder-and-bipolar-depression
#18
Yajing Pang, Heng Chen, Yifeng Wang, Zhiliang Long, Zongling He, Huangbin Zhang, Wei Liao, Qian Cui, Huafu Chen
Dysfunctional and abnormal functional connectivity in the right anterior insula (rAI) may underlie the pathophysiology of depression episode in bipolar disorder (BD) and of major depressive disorder (MDD). In this study, we examined the dynamic functional connectivity (dFC) of the rAI of 30 patients with BD, 30 patients with MDD, and 30 healthy controls. In the functional separation of rAI, the right dorsal AI (rdAI) and ventral AI (rvAI) were defined as seed regions. Sliding-window correlation of rAI subregions was implemented to measure the variance of dFC...
March 30, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29608617/prevalence-and-risk-factors-of-sexually-transmitted-infections-among-french-service-members
#19
Sandrine Duron, Henri Panjo, Aline Bohet, Christine Bigaillon, Sébastien Sicard, Nathalie Bajos, Jean-Baptiste Meynard, Audrey Mérens, Caroline Moreau
INTRODUCTION: Sexually Transmitted Infections (STIs) have always represented a public health concern in the military, yet most studies rely on self-reports among non-random samples of military populations. In addition, most of the studies exploring STI rates among the military focus on US service members. This paper assesses the prevalence and correlates of STIs in the French military using biomarkers and compares self-reported versus diagnosed STIs. METHODS: Data are drawn from the COSEMIL study, a national sexual health survey conducted in the French military in 2014 and 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29607310/urinary-metabolomic-study-of-chlorogenic-acid-in-a-rat-model-of-chronic-sleep-deprivation-using-gas-chromatography-mass-spectrometry
#20
Wei-Ni Ma, Ming-Mei Zhou, Xiao-Jun Gou, Le Zhao, Fang Cen, Ying Xu, Hong-Yi Shen
The urinary metabolomic study based on gas chromatography-mass spectrometry (GC-MS) had been developed to investigate the possible antidepressant mechanism of chlorogenic acid (CGA) in a rat model of sleep deprivation (SD). According to pattern recognition analysis, there was a clear separation among big platform group (BP), sleep deprivation group (SD), and the CGA (model + CGA), and CGA group was much closer to the BP group by showing a tendency of recovering towards BP group. Thirty-six significantly changed metabolites related to antidepressant by CGA were identified and used to explore the potential mechanism...
2018: International Journal of Genomics
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