keyword
MENU ▼
Read by QxMD icon Read
search

biomarker & depression

keyword
https://www.readbyqxmd.com/read/29454898/dietary-values-of-forsythia-suspensa-extract-in-penaeus-monodon-under-normal-rearing-and-vibrio-parahaemolyticus-3hp-vp-3hp-challenge-conditions-effect-on-growth-intestinal-barrier-function-immune-response-and-immune-related-gene-expression
#1
Jia-Jun Xie, Xu Chen, Tian-Yu Guo, Shi-Wei Xie, Hao-Hang Fang, Zhen-Lu Liu, Yan-Mei Zhang, Li-Xia Tian, Yong-Jian Liu, Jin Niu
Two trials were conducted to determine the effects of dietary Forsythia suspensa extract (FSE) on shrimp, Penaeus monodon, first on growth performance, second on the immune response and immune related gene expression of shrimp. In trial 1, shrimp (mean initial wet weight about 3.02 g) were fed with five diets containing 0% (basal diet), 0.01%, 0.02%, 0.04% and 0.06% FSE in triplicate for 60 days. Growth performance (final body wet weight, FBW; weight gain, WG; biomass gain, BG) of shrimp fed FSE diets were higher (P < 0...
February 15, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29454551/rostral-anterior-cingulate-cortex-is-a-structural-correlate-of-repetitive-tms-treatment-response-in-depression
#2
Aaron D Boes, Brandt D Uitermarkt, Fatimah M Albazron, Martin J Lan, Conor Liston, Alvaro Pascual-Leone, Marc J Dubin, Michael D Fox
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for medication-refractory major depression, yet the mechanisms of action for this intervention are poorly understood. Here we investigate cerebral cortex thickness as a possible biomarker of rTMS treatment response. METHODS: Longitudinal change in cortical thickness is evaluated relative to clinical outcomes across 48 participants in 2 cohorts undergoing left dorsolateral prefrontal cortex rTMS as a treatment for depression...
January 31, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29454180/tryptophan-kynurenine-and-lipid-related-metabolites-as-blood-biomarkers-for-first-episode-drug-na%C3%A3-ve-patients-with-major-depressive-disorder-an-exploratory-pilot-case-control-study
#3
Nobuki Kuwano, Takahiro A Kato, Daiki Setoyama, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Junji Kishimoto, Dongchon Kang, Shigenob Kanba
BACKGROUND: Early intervention in depression has been critical to prevent its negative impact including suicide. Recent blood biomarker studies for major depressive disorder (MDD) have suggested that tryptophan-kynurenine and lipid related metabolites are involved in the pathophysiology of MDD. However, there have been limited studies investigating these blood biomarkers in first-episode drug-naïve MDD, which are particularly important for early intervention in depression. METHODS: As an exploratory pilot case-control study, we examined the above blood biomarkers, and analyzed how these biomarkers are associated with clinical variables in first-episode drug-naïve MDD patients, based on metabolome/lipidome analysis...
January 31, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29453169/randomized-eeg-functional-brain-networks-in-major-depressive-disorders-with-greater-resilience-and-lower-rich-club-coefficient
#4
Minghui Zhang, Haiyan Zhou, Liqing Liu, Lei Feng, Jie Yang, Gang Wang, Ning Zhong
OBJECTIVE: Some studies have shown that the functional electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) networks in those with major depressive disorders (MDDs) have an abnormal random topology. In this study we aimed to further investigate the characteristics of the randomized functional brain networks in MDDs by examining resting-state scalp-EEG data. METHODS: Based on the methods of independent component analysis (ICA) and graph theoretic analysis, the abnormalities in the power spectral density (PSD) functional brain networks were compared between 13 MDDs and 13 matched healthy controls (HCs)...
January 31, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29451210/intravenous-morphine-self-administration-alters-accumbal-microrna-profiles-in-the-mouse-brain
#5
Juhwan Kim, Heh-In Im, Changjong Moon
A significant amount of evidence indicates that microRNAs (miRNAs) play an important role in drug addiction. The nucleus accumbens (NAc) is a critical part of the brain's reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have examined the expression of miRNAs and their functional roles in the NAc under conditions of morphine addiction. In this study, mice were intravenously infused with morphine (0.01, 0.03, 0.3, 1 and 3 mg/kg/infusion) and showed inverted U-shaped response...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29442234/microstructural-changes-in-patients-with-parkinson-disease-and-rem-sleep-behavior-disorder-depressive-symptoms-versus-non-depressed
#6
Farzaneh Ghazi Sherbaf, Farzaneh Rahmani, Sommayeh Mohammadi Jooyandeh, Mohammad Hadi Aarabi
Search for Parkinson's disease (PD) progression biomarkers has led to the identification of both motor and non-motor symptoms relevant of prodromal PD that could be eye-opening to the spreading underlying Lewy body pathogenesis. One most robust predictor of PD is the REM sleep behavior disorder (RBD), and one most common early non-motor symptom of PD is depression. With RBD, frequently coexisting with clinical depression and both predicting dopamine transmission dysfunction, we aimed to survey structural associates of depressive symptoms in early PD patients with comorbid RBD...
February 13, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29435648/interleukin-6-and-complement-serum-level-study-in-parkinson-s-disease
#7
Branislav Veselý, Michal Dufek, Vojtech Thon, Miroslav Brozman, Silvia Királová, Tatiana Halászová, Eva Koriťáková, Ivan Rektor
The objective of this study is to assess whether elevation of serum inflammatory markers levels may indicate the progression of clinical impairment in Parkinson's disease (PD) patients. In 47 PD patients, the serum levels of the C3 and C4 part of the complement and Interleukin-6 (IL-6) were measured. The results at baseline and after 2 years were correlated with scales measuring memory, depression, motor symptoms, and quality of life. Patients with higher levels of C3 and C4 at baseline had decreased quality of life, verbal ability, and memory...
February 12, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29429423/aberrant-topographical-organization-in-default-mode-network-in-first-episode-remitted-geriatric-depression-a-graph-theoretical-analysis
#8
Yan Zhu, Dongqing Wang, Zhe Liu, Yuefeng Li
BACKGROUND: Neuroimaging studies have shown that major depressive disorder is associated with altered activity patterns of the default-mode network (DMN). In this study, we sought to investigate the topological organization of the DMN in patients with remitted geriatric depression (RGD) and whether RGD patients would be more likely to show disrupted topological configuration of the DMN during the resting-state. METHODS: Thirty-three RGD patients and thirty-one healthy control participants underwent clinical and cognitive evaluations as well as resting-state functional magnetic resonance imaging scans...
February 12, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29427063/functional-brain-abnormalities-in-major-depressive-disorder-using-the-hilbert-huang-transform
#9
Haibin Yu, Feng Li, Tong Wu, Rui Li, Li Yao, Chuanyue Wang, Xia Wu
Major depressive disorder is a common disease worldwide, which is characterized by significant and persistent depression. Non-invasive accessory diagnosis of depression can be performed by resting-state functional magnetic resonance imaging (rs-fMRI). However, the fMRI signal may not satisfy linearity and stationarity. The Hilbert-Huang transform (HHT) is an adaptive time-frequency localization analysis method suitable for nonlinear and non-stationary signals. The objective of this study was to apply the HHT to rs-fMRI to find the abnormal brain areas of patients with depression...
February 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29426824/plasma-a%C3%AE-analysis-using-magnetically-labeled-immunoassays-and-pet-18f-florbetapir-binding-in-non-demented-patients-with-major-depressive-disorder
#10
Kuan-Yi Wu, Ing-Tsung Hsiao, Chia-Hsiang Chen, Chia-Yih Liu, Jung-Lung Hsu, Sheng-Yao Huang, Tzu-Chen Yen, Kun-Ju Lin
An increased level of brain amyloid deposition and a decreased level of cerebral spinal fluid (CSF) Aβ42 are currently considered reliable biomarkers of Alzheimer's disease (AD); however, the usefulness of plasma Aβ levels are not well-established. This study investigated the relationships between plasma Aβ levels and cerebral amyloidosis in 36 non-demented patients with major depressive disorder (MDD). All participants underwent 18F-florbetapir PET imaging and provided a blood sample at the same time for immunomagnetic reduction assay to measure the plasma levels of Aβ40 and Aβ42...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29421445/relationships-between-allostatic-load-unhealthy-behaviors-and-depressive-disorder-in-u-s-adults-2005-2012-nhanes
#11
Erik J Rodriquez, Jennifer Livaudais-Toman, Steven E Gregorich, James S Jackson, Anna M Nápoles, Eliseo J Pérez-Stable
Unhealthy behaviors may modify relationships between chronic stress and depression among diverse older adults. We analyzed nationally representative cross-sectional data from participants aged 40-79 years of the 2005-2012 National Health and Nutrition Examination Survey. Unhealthy behaviors included current smoking, excessive/binge drinking, insufficient physical activity, and fair/poor diet. Allostatic load was defined by 10 biomarkers indicating the cumulative physiologic burden of stress. Depressive disorder was assessed using the Patient Health Questionnaire...
February 5, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29417836/heart-rate-variability-as-a-marker-of-distress-and-recovery-the-effect-of-brief-supportive-expressive-group-therapy-with-mindfulness-in-cancer-patients
#12
HyeYoun Park, Sohee Oh, Yumi Noh, Ju Young Kim, Jeong-Hyun Kim
OBJECTIVES: We aimed to investigate the effects of brief supportive expressive group therapy with mindfulness for cancer patients and to assess the utility of heart rate variability (HRV) as a biomarker of distress and treatment effect. METHODS: A total of 28 female patients with nonmetastatic cancer at a university hospital in South Korea received a 4-week modified group therapy for distress reduction. The BESTMIND (Brief Expression and Support Therapy with Mindfulness) program consisted of supportive-expressive group therapy and mindfulness-based stress reduction...
February 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29414028/relation-of-long-term-patterns-in-caregiving-activity-and-depressive-symptoms-to-telomere-length-in-older-women
#13
Shun-Chiao Chang, Marta Crous-Bou, Jennifer Prescott, Bernard Rosner, Naomi M Simon, Wei Wang, Immaculata De Vivo, Olivia I Okereke
BACKGROUND: Research links psychological stress to accelerated cellular aging. Here we examined whether long-term patterns of depression and caregiving burden, forms of chronic psychological stress, were associated with shorter telomere length, a biomarker of cellular aging. METHODS: The study included 1250 healthy older women (mean: 68.0; range: 60-81 years) in the Nurses' Health Study. Long-term patterns in depressive symptoms and caregiving activity (separated into care of children/grandchildren vs...
January 9, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29413077/depression-and-pharmacogenetics
#14
David Nana Ampong
Depression is the most common and leading devastating psychiatric illness that affects a majority of the world population. The treatment of depression has been a challenge for a majority of patients and healthcare practitioners. The advent of pharmacogenomics (PGx) empowered the Food and Drug Administration to approve some antidepressant biomarkers for PGx model of treatment. The PGx testing identifies whether an individual is a poor metabolizer, ultra/rapid metabolizer, intermediate metabolizer, or essential metabolizer of an antidepressants before prescription...
February 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29412840/neurologic-changes-and-depression
#15
REVIEW
Ryan D Greene, Sophia Wang
This article covers current research on the relationship between depression and cognitive impairment in older adults. First, it approaches the clinical assessment of late-life depression and comorbid cognitive impairment. Cognitive risk factors for suicide are discussed. Research is then provided on neuropsychological changes associated with depression, discussing subjective cognitive impairment, mild cognitive impairment, and dementia profiles. Additionally, literature regarding neuroimaging and biomarker findings in depressed older adults is presented...
March 2018: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/29412004/neural-response-to-pleasant-pictures-moderates-prospective-relationship-between-stress-and-depressive-symptoms-in-adolescent-girls
#16
Amanda R Levinson, Brittany C Speed, Greg Hajcak
Adolescent girls are at increased risk for depression, which is thought to result from the interaction of biological vulnerabilities and life stressors common to adolescent girls. A blunted late positive potential (LPP) to emotional stimuli (i.e., pleasant and unpleasant) has been associated with depressive symptoms and risk. The current study of adolescent girls examines the moderating effects of the LPP, a candidate biomarker of depression, of the link between life stress and increases in depressive symptoms over 1 year...
February 7, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29411705/-vascular-endothelial-growth-factor-vegf-as-a-potential-biomarker-in-major-depressive-disorder
#17
Monika Elemery, Szilvia Kiss, Xenia Gonda, Peter Dome, Judit Lazary
BACKGROUND: There is growing evidence that vascular endothelial growth factor (VEGF) plays a crucial role in neurodevelopment and regeneration. Several data support that intact VEGF pathway is indispensable for therapeutic effect of antidepressants, any disruption of VEGF signaling can result treatment resistance. In our study we investigated the peripherial blood VEGF level before and 4-week after antidepressant treatment in patients with major depressive episode and we compared VEGF levels between responders and non-responders...
December 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/29410157/regulatory-accepted-drug-development-tools-are-needed-to-accelerate-innovative-cns-disease-treatments
#18
REVIEW
Stephen P Arnerić, Volker D Kern, Diane T Stephenson
Central Nervous System (CNS) diseases represent one of the most challenging therapeutic areas for successful drug approvals. Developing quantitative biomarkers as Drug Development Tools (DDTs) can catalyze the path to innovative treatments, and improve the chances of drug approvals. Drug development and healthcare management requires sensitive, reliable, validated, and regulatory accepted biomarkers and endpoints. This review highlights the regulatory paths and considerations for developing DDTs required to advance biomarker and endpoint use in clinical development (e...
January 30, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29407731/evaluating-health-related-quality-of-life-impact-of-chronic-conditions-among-older-adults-from-a-rural-town-in-suzhou-china
#19
Chen-Wei Pan, Xiao-Ling Cong, Hui-Jun Zhou, Xing-Zhi Wang, Hong-Peng Sun, Yong Xu, Pei Wang
This study aimed to estimate the loss of health-related quality of life (HRQOL) associated with common chronic conditions in older Chinese population.Weitang Geriatric Diseases Study is a community-based health survey on 5557 Chinese aged 60 years or older. The study population was measured with EQ-5D-3L for HRQOL assessment. We also assessed the coexisting chronic conditions of depression, cognitive dysfunction, stroke, heart disease, diabetes, hypertension, obesity, hyperlipidemia and visual impairment based on self-completed questionnaires, biomarkers and medical records...
February 2, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29405799/female-psychopharmacology-matters-towards-a-sex-specific-psychopharmacology
#20
Blanca Bolea-Alamanac, Sarah J Bailey, Thelma A Lovick, Dirk Scheele, Rita Valentino
There is increasing recognition that women have a higher prevalence of certain psychiatric illnesses, and a differential treatment response and course of illness compared to men. Additionally, clinicians deal with a number of disorders like premenstrual syndrome, premenstrual dysphoric disorder, and postpartum depression, which affect women specifically and for which treatment and biological pathways are still unclear. In this article we highlight recent research which suggests that different biological mechanisms may underlie sex differences in responsiveness to stress...
January 1, 2018: Journal of Psychopharmacology
keyword
keyword
37855
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"