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biomarker & depression

Bhaskar Roy, Yogesh Dwivedi
Stressful life incidents often cause a predisposition for developing mental disorders such as major depressive disorder (MDD). Impaired neurocognitive and neuro-vegetative functions of the central nervous system are the hallmarks of this mental illness. Blunted responses from emotionally salient regions of the brain including cortex, hippocampus, and amygdala have been associated with MDD-related behavioral changes. Moreover, improper signal processing and neuronal atrophy were held responsible for the overall dysfunctionality of these vulnerable regions in the MDD brain...
2018: Progress in Molecular Biology and Translational Science
Gozde Gundogdu Meydaneri, Sertac Meydaneri
Background Neutrophil lymphocyte rate (NLR), platelet lymphocyte rate (PLR), and systemic immune inflammatory index (SIII) are rates obtained from hemogram parameters, and they are biomarkers used for the diagnoses of many diseases and their severity, and prediction of disease. In addition to the NLR, PLR, and SIII, platelets, plateletcrit (PCT), and platelet distribution width (PDW), which are platelet indices, are also investigated as biomarkers in many diseases. There are limited studies on the use of hemogram derivates (NLR, PLR, and SIII) in the diagnosis and severity determination of psychiatric disorders...
April 19, 2018: Curēus
Josh Allen, Raquel Romay-Tallon, Kyle J Brymer, Hector J Caruncho, Lisa E Kalynchuk
Human and animal studies suggest an intriguing link between mitochondrial diseases and depression. Although depression has historically been linked to alterations in monoaminergic pharmacology and adult hippocampal neurogenesis, new data increasingly implicate broader forms of dampened plasticity, including plasticity within the cell. Mitochondria are the cellular powerhouse of eukaryotic cells, and they also regulate brain function through oxidative stress and apoptosis. In this paper, we make the case that mitochondrial dysfunction could play an important role in the pathophysiology of depression...
2018: Frontiers in Neuroscience
Håvard Hamarsland, Gøran Paulsen, Paul A Solberg, Ole Gunnar Slaathaug, Truls Raastad
INTRODUCTION: The aim of this study was to investigate the effect of an arduous one-week military course on measures of physical performance, body composition and blood biomarkers. METHODS: Participants were apprentices in an annual selection course for the Norwegian Special Forces. Fifteen soldiers (23±4 yrs., 1.81±0.06 m, 78±7 kg) completed a hell-week consisting of rigorous activity only interspersed by 2-3 hours of sleep per day. Testing was conducted before and 0, 1, 3, 7 and 14 days after the hell-week...
June 21, 2018: Medicine and Science in Sports and Exercise
Kuan-Yi Wu, Kun-Ju Lin, Chia-Hsiang Chen, Cheng-Sheng Chen, Chia-Yih Liu, Sheng-Yao Huang, Tzu-Chen Yen, Ing-Tsung Hsiao
BACKGROUND: Patients with late-life depression may be at the preclinical stage of dementia. However, the neurodegenerative processes in late-life depression are poorly understood. This study aimed to investigate the distribution patterns of amyloid pathology and neurodegeneration in a depressive population without dementia. METHODS: The study recruited 63 middle-aged and elderly patients with major depressive disorder (MDD) and 22 control subjects. The MDD patients were further subdivided into those with mild cognitive impairment (MCI) (n = 24) and non-MCI (n = 39) patients...
June 21, 2018: Brain and Behavior
A Adhikari, R Dikshit, S Karia, S Sonavane, N Shah, A De Sousa
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) and C-reactive protein (CRP) level are useful biomarkers of inflammation. This study aimed to assess NLR and CRP level in patients with major depressive disorder before and after pharmacotherapy to determine whether NLR or CRP could be used as biomarkers of severity of major depression and whether there was any sex difference. METHODOLOGY: Patients with major depression who received no pharmacotherapy 1 month prior to the study were included...
June 2018: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
Aleyda Benitez-Amaro, Valerie Samouillan, Esther Jorge, Jany Dandurand, Laura Nasarre, David de Gonzalo-Calvo, Olga Bornachea, Gerard Amoros-Figueras, Colette Lacabanne, David Vilades, Ruben Leta, Francesc Carreras, Alberto Gallardo, Enrique Lerma, Juan Cinca, Jose M Guerra, Vicenta Llorente-Cortés
Our aim was to identify biophysical biomarkers of ventricular remodelling in tachycardia-induced dilated cardiomyopathy (DCM). Our study includes healthy controls (N = 7) and DCM pigs (N = 10). Molecular analysis showed global myocardial metabolic abnormalities, some of them related to myocardial hibernation in failing hearts, supporting the translationality of our model to study cardiac remodelling in dilated cardiomyopathy. Histological analysis showed unorganized and agglomerated collagen accumulation in the dilated ventricles and a higher percentage of fibrosis in the right (RV) than in the left (LV) ventricle (P = ...
June 19, 2018: Journal of Cellular and Molecular Medicine
Christine Wyss, Desmond H Y Tse, Frank Boers, Jon Shah N, Irene Neuner, Wolfram Kawohl
Loudness dependence of auditory evoked potentials (LDAEP) is a widely used electroencephalography (EEG) based biomarker for central serotonergic activity. Serotonin has been shown to be associated with different psychiatric disorders such as depression and schizophrenia. Despite its clinical significance, the underlying neurochemical mechanism of this promising marker is not fully understood and further research is needed to improve its validity. Other neurotransmitters might have a significant impact on this measure...
June 15, 2018: International Journal of Neuropsychopharmacology
Liya Lu, Jennifer Deane, Linda Sharp
PURPOSE OF REVIEW: The number of cancer survivors is growing due to population ageing, earlier detection and more effective therapies. Routinely collected data (RCD), generally cancer registry data, has been used to investigate survivors' needs and outcomes. We reviewed uses of RCD since 2017, identifying novel findings and research directions. RECENT FINDINGS: Survival is improving internationally but continues to vary between subgroups. Longitudinal survivor surveys suggest malignancy-specific temporal patterns in unmet needs and health-related quality-of-life (HRQoL)...
June 18, 2018: Current Opinion in Supportive and Palliative Care
Pedro Zuzarte, Gustavo Scola, Angela Duong, Kari Kostiw, Maria L Figueira, Atilio Costa-Vitali
Depression and anxiety are prevalent in patients with heart failure (HF). Reduced ejection fraction (EF) and increased N-terminal-prohormone B-type natriuretic peptide (NT-proBNP) have been shown to be independently associated with depressive symptoms and may therefore increase HF disease progression and mortality. This study evaluated whether NT-proBNP mediated the impact of reduced EF on depressive and anxiety symptoms in patients with HF. Participants (n = 124) were patients with a diagnosis of chronic HF enrolled in the Heart Failure Disease Management Program at Health Sciences North...
June 9, 2018: Journal of Psychiatric Research
Jessica Gill, Maja Mustapic, Ramon Diaz-Arrastia, Rael Lange, Seema Gulyani, Tom Diehl, Vida Motamedi, Nicole Osier, Robert A Stern, Dimitrios Kapogiannis
OBJECTIVE: Identify biomarkers in peripheral blood that relate to chronic post-concussive and behavioural symptoms following traumatic brain injuries (TBIs) to ultimately improve clinical management. RESEARCH DESIGN: We compared military personnel with mild TBIs (mTBIs) (n = 42) to those without TBIs (n = 22) in concentrations of tau, amyloid-beta (Aβ42) and cytokines (tumour necrosis factor alpha (TNFα, interleukin (IL)-6 and -10) in neuronal-derived exosomes from the peripheral blood...
June 18, 2018: Brain Injury: [BI]
Rosa Freitas, Francesca Coppola, Lucia De Marchi, Valeria Codella, Carlo Pretti, Federica Chiellini, Andrea Morelli, Gianluca Polese, Amadeu M V M Soares, Etelvina Figueira
Although an increasing number of studies have been published on the effects of emergent pollutants such as carbon nanoparticles, there is still scarce information on the impact of these contaminants on marine organisms when acting in combination with classical pollutants such as meta(loid)s. The present study evaluated the impacts of Arsenic and Multi-Walled Carbon Nanotubes (MWCNTs) in the clam Ruditapes philippinarum, assessing the effects induced when both contaminants were acting individually (As, NP) and as a mixture (As + NP)...
June 2, 2018: Journal of Hazardous Materials
Chiara Fabbri, Alessandro Serretti
A frustrating inertia has affected the development of clinical applications of antidepressant pharmacogenetics and personalized treatments of depression are still lacking 20 years after the first findings. Candidate gene studies provided replicated findings for some polymorphisms, but each of them shows at best a small effect on antidepressant efficacy and the cumulative effect of different polymorphisms is unclear. Further, no candidate was immune by at least some negative studies. These considerations give rise to some concerns about the clinical benefits of currently available pharmacogenetic tests since they are based on the results of candidate gene studies...
June 12, 2018: Neuroscience Letters
Alexander Pilger, Helmuth Haslacher, Bernhard M Meyer, Alexandra Lackner, Selma Nassan-Agha, Sonja Nistler, Claudia Stangelmaier, Georg Endler, Andrea Mikulits, Ingrid Priemer, Franz Ratzinger, Elisabeth Ponocny-Seliger, Evelyne Wohlschläger-Krenn, Manuela Teufelhart, Heidemarie Täuber, Thomas M Scherzer, Thomas Perkmann, Galateja Jordakieva, Lukas Pezawas, Robert Winker
Burnout and work-related stress symptoms of anxiety disorder and depression cause prolonged work absenteeism and early retirement. Hence, reliable identification of patients under risk and monitoring of treatment success is highly warranted. We aimed to evaluate stress-specific biomarkers in a population-based, "real-world" cohort (burnouts: n = 40, healthy controls: n = 26), recruited at a preventive care ward, at baseline and after a four-month follow up, during which patients received medical and psychological treatment...
June 14, 2018: Scientific Reports
Nitzan Zohar, Eldar Hochman, Nachum Katz, Amir Krivoy, Abraham Weizman, Ran Barzilay
The interplay between the immune system and behaviour is of increasing interest in psychiatry research. Specifically, accumulating data points to a link between inflammation and psychopathology, including affective symptomatology. We investigated the association between inflammation and affective polarity in psychiatric inpatients who were hospitalized due to an affective exacerbation. Data was collected retrospectively and comparisons were made between manic and depressed patients. C-reactive protein (CRP), a general laboratory marker of immune activation and inflammation, was used as a non-specific inflammatory biomarker...
June 14, 2018: Neuropsychobiology
Hada Fong-Ha Ieong, Zhen Yuan
Many patients with substance use disorders (SUDs) live in a stressful environment, and comorbidity is not uncommon. Understanding the neural mechanisms underlying heroin and nicotine dependences and their relationships to social cognition could facilitate behavioral therapy efficacy. We aimed to provide a translational approach that leads to identifying potential biomarkers for opioid use disorder (OUD) susceptibility during recovery. We examined the clinical characters and the relationships between theory of mind (ToM) and executive functions in three groups: heroin plus nicotine-dependent (HND) patients who had remained heroin abstinent ( <mml:math xmlns:mml="http://www...
April 2018: Neurophotonics
F T Fellendorf, M Platzer, R Pilz, A Rieger, H P Kapfhammer, H Mangge, N Dalkner, S Zelzer, A Meinitzer, A Birner, S A Bengesser, R Queissner, C Hamm, R Hartleb, E Z Reininghaus
OBJECTIVES: An important aspect of bipolar disorder (BD) research is the identification of biomarkers pertaining to the somatic health state. The branched-chain essential amino acids (BCAAs), viz valine, leucine and isoleucine, have been proposed as biomarkers of an individual's health state, given their influence on protein synthesis and gluconeogenesis inhibition. METHODS: BCAA levels of 141 euthymic/subsyndromal individuals with BD and 141 matched healthy controls (HC) were analyzed by high-pressure lipid chromatography and correlated with clinical psychiatric, anthropometric and metabolic parameters...
June 14, 2018: World Journal of Biological Psychiatry
Zsuzsanna Jeremias, Nora Rat, Imre Benedek, Emese Rapolti, Mihaela Ratiu, Adrian Muresan, Theodora Benedek
BACKGROUND: The role of vascular calcifications in iliac arteries for predicting global atherosclerotic burden in still unknown. The aim of this study was to investigate whether iliac calcium score (ICS), a new computed tomographic angiography (CTA) derived biomarker of vascular calcification, can predict the severity and complexity of peripheral arterial disease (PAD) as well as the global atherosclerotic burden. PATIENTS AND METHODS: This was a single centre, non-randomized, observational prospective study on 84 consecutive patients with symptomatic peripheral arterial disease, undergoing peripheral CTA examination of the lower limbs, divided into high (n = 42) and low ICS (n = 42) groups with a median value for ICS of 3934 HU...
June 13, 2018: VASA. Zeitschrift Für Gefässkrankheiten
Jennifer C Felger, Ebrahim Haroon, Trusharth A Patel, David R Goldsmith, Evanthia C Wommack, Bobbi J Woolwine, Ngoc-Anh Le, Rachel Feinberg, Malu G Tansey, Andrew H Miller
Peripheral blood C-reactive protein (CRP) is a biomarker used clinically to measure systemic inflammation and is reproducibly increased in a subset of patients with major depressive disorder (MDD). Furthermore, increased peripheral blood CRP in MDD has been associated with altered reward circuitry and increased brain glutamate in relation with symptoms of anhedonia. Nevertheless, the relationship between peripheral CRP and other peripheral and central markers of inflammation in depressed patients has not been established...
June 12, 2018: Molecular Psychiatry
Thomas C Baghai, Gabriella Varallo-Bedarida, Christoph Born, Sibylle Häfner, Cornelius Schüle, Daniela Eser, Peter Zill, André Manook, Johannes Weigl, Somayeh Jooyandeh, Caroline Nothdurfter, Clemens von Schacky, Brigitta Bondy, Rainer Rupprecht
BACKGROUND: Cardiovascular disorders (CVD) and major depressive disorder (MDD) are the most frequent diseases worldwide responsible for premature death and disability. Behavioral and immunological variables influence the pathophysiology of both disorders. We therefore determined frequency and severity of MDD in CVD and studied whether MDD without CVD or other somatic diseases influences classical and inflammatory biomarkers of cardiovascular risk. In addition, we investigated the influence of proinflammatory cytokines on antidepressant treatment outcome...
June 12, 2018: International Journal of Molecular Sciences
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