Lucas Santos, Luiza Behrens, Camila Barbosa, Camila Tiefensee-Ribeiro, Helen Rosa-Silva, Nauana Somensi, Pedro Ozorio Brum, Alexandre Kleber Silveira, Matheus Scarpatto Rodrigues, Jade de Oliveira, Daniel Pens Gelain, Roberto F Almeida, José Cláudio Fonseca Moreira
Major Depressive Disorder (MDD) is a severe and multifactorial psychiatric condition. Evidence has shown that environmental factors, such as stress, significantly explain MDD pathophysiology. Studies have hypothesized that changes in histone methylation patterns are involved in impaired glutamatergic signaling. Based on this scenario, this study aims to investigate histone 3 involvement in depression susceptibility or resilience in MDD pathophysiology by investigating cellular and molecular parameters related to i) glutamatergic neurotransmission, ii) astrocytic functioning, and iii) neurogenesis...
January 16, 2024: Molecular Neurobiology