Kun Qing, Talissa A Altes, John P Mugler, Jaime F Mata, Nicholas J Tustison, Kai Ruppert, Juliana Bueno, Lucia Flors, Yun M Shim, Li Zhao, Joanne Cassani, William G Teague, John S Kim, Zhixing Wang, Iulian C Ruset, F William Hersman, Borna Mehrad
PURPOSE: The existing tools to quantify lung function in interstitial lung diseases have significant limitations. Lung MRI imaging using inhaled hyperpolarized xenon-129 gas (129 Xe) as a contrast agent is a new technology for measuring regional lung physiology. We sought to assess the utility of the 129 Xe MRI in detecting impaired lung physiology in usual interstitial pneumonia (UIP). MATERIALS AND METHODS: After institutional review board approval and informed consent and in compliance with HIPAA regulations, we performed chest CT, pulmonary function tests (PFTs), and 129 Xe MRI in 10 UIP subjects and 10 healthy controls...
May 25, 2023: Biomedicines