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https://www.readbyqxmd.com/read/28432481/the-pretreatment-neutrophil-to-lymphocyte-ratio-is-a-prognostic-determinant-of-t3-4-hypopharyngeal-squamous-cell-carcinoma
#1
Wu-Chia Lo, Chen-Tu Wu, Cheng-Ping Wang, Tsung-Lin Yang, Pei-Jen Lou, Jeng-Yuh Ko, Yih-Leong Chang
OBJECTIVE: This study aimed to investigate the clinicopathological factors that influence recurrence and survival in patients who undergo operations for T3-4 hypopharyngeal squamous cell carcinomas (SCCs). MATERIALS AND METHODS: One hundred and five patients who underwent surgery between 2001 and 2008 for advanced hypopharyngeal SCCs were consecutively enrolled and reviewed. RESULTS: The pretreatment neutrophil-to-lymphocyte ratio (NLR; median 3...
April 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28432444/endoscopic-ultrasonography-and-computed-tomography-scanning-for-preoperative-staging-of-colonic-cancer
#2
M L Malmstrøm, I Gögenur, L B Riis, H Hassan, T W Klausen, T Perner, A Săftoiu, P Vilmann
PURPOSE: With an increasing demand for more accurate preoperative staging methods for colon cancer, we aimed to compare preoperative tumour (T)- and nodal (N)-stage in patients with left-sided colon cancer by endoscopic ultrasonography (EUS) and computed tomography (CT) with post-operative histology as gold standard. METHODS: A total of 44 patients were prospectively recruited at Herlev and Roskilde University Hospitals during November 2014-January 2016. Thirty-five patients were included in the final analysis and underwent EUS, CT and surgery within 2 weeks...
April 21, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28423882/various-levels-of-rapeseed-meal-in-weaning-pig-diet-from-weaning-to-finishing-periods
#3
Sung Ho Do, Byeong Ock Kim, Lin Hu Fang, Dong Hyeon You, Jin Su Hong, Y Y Kim
Objective: This experiment was conducted to investigate the influence of rapeseed meal (RSM) supplementation in weaning pig diet on growth performance, blood profile, carcass characteristics and economic analysis on weaning to finishing pigs. Methods: A total of 120 cross bred ([Yorkshire × Landrace] × Duroc) weaning pigs were allotted to 5 treatments in a randomized complete block (RCB) design. Each treatment had 4 replications with 6 pigs per pen. Five different levels of RSM (0, 2, 4, 6 and 8%) were used as dietary treatments...
March 25, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28422886/comparison-of-t2-and-t3-sympathectomy-for-compensatory-sweating-on-palmar-hyperhidrosis
#4
Atila Turkyilmaz, Sami Karapolat, Kubra Nur Seyis, Celal Tekinbas
BACKGROUND: An otherwise successfully performed endoscopic thoracic sympathectomy (ETS) to treat palmar hyperhidrosis (PH) often has a serious side effect: compensatory sweating (CS). This side effect occurs in other parts of the body to a disturbing extent. The objective of this study is to determine whether there is a relationship between the level of ETS performed on patients with PH, and the occurrence and severity of postoperational CS. METHODS: Between January 2014 and January 2015, ETS procedures were performed on 25 randomly selected consecutive subjects (group A) at T2 level, and on another 25 subjects (group B) at T3 level, who all felt severely handicapped due to PH...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422874/consort-the-effect-of-intraoperative-dexmedetomidine-on-hemodynamic-responses-during-emergence-from-nasotracheal-intubation-after-oral-surgery
#5
Youn Yi Jo, Hong Soon Kim, Kyung Cheon Lee, Young Jin Chang, Youseok Shin, Hyun Jeong Kwak
BACKGROUND: Dexmedetomidine provides smooth emergence with reduced agitation. The authors hypothesized low-dose dexmedetomidine infusion might contribute to hemodynamic stability during and after nasotracheal tube extubation. METHODS: Ninety-three adult patients scheduled for oral and maxillofacial surgery were enrolled in this prospective study. Patients were randomly assigned to receive normal saline (control group, n = 31), dexmedetomidine at 0.2 μg/kg/h (DEX0...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422732/molecular-and-serologic-markers-of-hpv-16-infection-are-associated-with-local-recurrence-in-patients-with-oral-cavity-squamous-cell-carcinoma
#6
Chung-Guei Huang, Li-Ang Lee, Chun-Ta Liao, Tzu-Chen Yen, Shu-Li Yang, Yi-Chun Liu, Jung-Chin Li, Yu-Nong Gong, Chung-Jan Kang, Shiang-Fu Huang, Ku-Hao Fang, Kai-Ping Chang, Li-Yu Lee, Chuen Hsueh, Shin-Ru Shih, Kuo-Chien Tsao
Human papillomavirus (HPV) infections predict mortality in Taiwanese patients with oral cavity squamous cell carcinoma (OCSCC). To address their prognostic significance for local recurrence (LR), in this retrospective cohort study we investigated different serologic and molecular markers of HPV 16 infection in 85 consecutive patients with primary OCSCC who received standard treatment and had their sera stored before treatment. Resected tumor specimens were examined with PCR-based assays for HPV 16 E6/E7 mRNA expression...
March 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422550/evaluation-of-the-diagnostic-accuracy-of-ubc-%C3%A2-rapid-in-bladder-cancer-a-swedish-multicentre-study
#7
Johan Styrke, Helene Henriksson, Börje Ljungberg, Mudhar Hasan, Ingrid Silfverberg, Roland Einarsson, Per-Uno Malmström, Amir Sherif
OBJECTIVE: The aim of this study was to determine the diagnostic accuracy of UBC(®) Rapid - a urine-based marker for bladder cancer - in patients with bladder cancer and controls, and to compare the test results across risk groups. MATERIALS AND METHODS: This prospective phase II study was conducted at four Swedish hospitals. UBC Rapid was evaluated in four groups: A, newly diagnosed bladder cancer (n = 94); B, follow-up of non-muscle-invasive bladder cancer (n = 75); C, benign urinary tract diseases (n = 51); and D, healthy controls (n = 50)...
April 19, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28420821/use-of-liothyronine-without-levothyroxine-in-the-treatment-of-mild-consumptive-hypothyroidism-caused-by-hepatic-hemangiomas
#8
Shinji Higuchi, Masaki Takagi, Yukihiro Hasegawa
There have been reports of the use of levothyroxine or levothyroxine plus liothyronine for consumptive hypothyroidism caused by hepatic hemangiomas. Administration of levothyroxine without liothyronine can be inadequate to maintain normal levels of both free T3 and free T4 in some patients. However, there is no report of treatment with liothyronine plus propranolol. We herein present a case in which we used liothyronine therapy for multifocal hepatic hemangiomas in a Japanese patient with low free T3 and normal free T4 levels...
April 18, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28417239/incidental-gallbladder-cancer-residual-cancer-discovered-at-oncologic-extended-resection-determines-outcome-a-report-from-high-and-low-incidence-countries
#9
Eduardo Vinuela, Eduardo A Vega, Suguru Yamashita, Marcel Sanhueza, Rosemarie Mege, Gabriel Cavada, Thomas A Aloia, Yun Shin Chun, Jeffrey E Lee, Jean-Nicolas Vauthey, Claudius Conrad
BACKGROUND: Gallbladder cancer detected incidentally after cholecystectomy (IGBC) currently is the most common diagnosis of gallbladder cancer, and oncologic extended resection (OER) is recommended for tumors classified higher than T1b. However, the precise prognostic significance of residual cancer (RC) found at the time of OER has not been well established. This analysis aimed to determine the prognostic impact of RC found in patients with IGBC undergoing OER. METHODS: Outcomes for IGBC at a center for a low-incidence country (USA) and a high-incidence country (Chile) between January 1999 and June 2015 were analyzed...
April 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28413435/low-prevalence-of-human-mammary-tumor-virus-hmtv-in-breast-cancer-patients-from-myanmar
#10
Thar Htet San, Masayoshi Fujisawa, Soichiro Fushimi, Teizo Yoshimura, Toshiaki Ohara, Lamin Soe, Ngu Wah Min, Ohnmar Kyaw, Xu Yang, Akihiro Matsukawa
BACKGROUND: Human mammary tumor virus (HMTV) is 90-95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors. HMTV (MMTV-like) sequences were reported to be present in human breast cancers from several populations with a prevalence range of 0-78%; however, the prevalence of HMTV in breast cancers from Myanmar remains unknown. METHODS: Fifty-eight breast cancer samples from Myanmar women were examined in this study. DNA was isolated from formalin-fixed paraffin-embedded specimens, and HMTV envelope sequences were detected by semi-nested PCR...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28404531/an-integrated-method-of-therapeutic-lifestyle-change-for-older-adults-with-dyslipidaemia
#11
J-Y Zhao, H Li, S Jin, X-H Chen, L-L Chen
OBJECTIVES: To evaluate the effect of therapeutic lifestyle change with a non-pharmacological intervention method in older adults with dyslipidaemia. STUDY DESIGN: Stratified randomized trial. METHODS: Participants with dyslipidaemia (n = 214) aged ≥60 years were randomized to the conventional guide group, the educational course (EC) group, the telephone call (PC) group or the PC + EC group for 24 weeks. Total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and the knowledge, attitude and practice score for serum lipids were measured at baseline (T1), mid-intervention (week 12, T2) and post-intervention (week 24, T3)...
April 5, 2017: Public Health
https://www.readbyqxmd.com/read/28399840/a-multicentre-randomised-controlled-trial-to-evaluate-the-efficacy-morbidity-and-functional-outcome-of-endoscopic-transanal-proctectomy-versus-laparoscopic-proctectomy-for-low-lying-rectal-cancer-etap-greccar-11-trial-rationale-and-design
#12
Bernard Lelong, Cécile de Chaisemartin, Helene Meillat, Sandra Cournier, Jean Marie Boher, Dominique Genre, Mehdi Karoui, Jean Jacques Tuech, Jean Robert Delpero
BACKGROUND: Total mesorectal excision is the standard surgical treatment for mid- and low-rectal cancer. Laparoscopy represents a clear leap forward in the management of rectal cancer patients, offering significant improvements in post-operative measures such as pain, first bowel movement, and hospital length of stay. However, there are still some limits to its applications, especially in difficult cases. Such cases may entail either conversion to an open procedure or positive resection margins...
April 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28399511/study-protocol-for-a-natural-experiment-in-a-lower-socioeconomic-area-to-examine-the-health-related-effects-of-refurbishment-to-parks-including-built-shade-shadeplus
#13
S J Dobbinson, J Veitch, J Salmon, M Wakefield, P K Staiger, R J MacInnis, J Simmons
INTRODUCTION: Parks in disadvantaged suburbs often have low quality and few amenities, which is likely to result in them being underutilised for recreation and physical activity. Refurbishment of parks, including shade, walking paths and other amenities, may have broad health-related benefits. METHODS AND ANALYSIS: The study design, methods and planned analyses for a natural experiment examining the effects of refurbishments including built-shade added to parks in disadvantaged outer suburbs of Melbourne are described...
February 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28379681/morphology-control-in-films-of-isoindigo-polymers-by-side-chain-and-molecular-weight-effects
#14
Caroline Grand, Wojciech Zajaczkowski, Nabankur Deb, Chi Kin Lo, Jeff L Hernandez, David G Bucknall, Klaus Müllen, Wojciech Pisula, John R Reynolds
The performance of devices relying on organic electronic materials, such as organic field-effect transistors (OFET) and organic photovoltaics (OPV), is strongly correlated to the morphology of the conjugated material in thin films. For instance, several factors such as polymer solubility, weak intermolecular forces between polymers and fullerene derivatives, and film drying time impact phase separation in the active layer of a bulk heterojunction OPV device. In an effort to probe the influence of polymer assembly on morphology of polymer thin films and phase separation with fullerene derivatives, five terthiophene-alt-isoindigo copolymers were synthesized with alkyl side-chains of varying lengths and branching on the terthiophene unit...
April 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28376913/the-t4-t3-quotient-as-a-risk-factor-for-differentiated-thyroid-cancer-a-case-control-study
#15
Mark Sasson, Emily Kay-Rivest, Rami Shoukrun, Anca Florea, Michael Hier, Veronique-Isabelle Forest, Michael Tamilia, Richard J Payne
BACKGROUND: The incidence of thyroid nodules is increasing among patients in North America. Few of these nodules harbour malignancy, thus further research is required to identify predictive markers of malignant thyroid disease. This study set out to understand the relationship between the levels of fT4 and fT3 and differentiated thyroid cancer. METHODS: A case-control study was conducted with 142 cases and 86 controls from the McGill University Teaching Hospitals...
April 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28372300/thyroid-hormone-disorders-and-sepsis
#16
Bin Luo, Zhui Yu, Yinping Li
Sepsis is a systemic inflammatory response syndrome with high mortality, which results from severe infection and can lead to secondary organ dysfunction. It is one of the most common cause of death in intensive care unit. Clinical reports have shown that sepsis was often accompanied by thyroid dysfunction, which is called "low triiodothyronine (T3)" syndrome and characterized by decreased blood total T3 and free T3, and by normal or decreased thyroxine (T4) and thyroid stimulating hormone (TSH). This syndrome may greatly affect the prognosis of patients with sepsis...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28365894/gene-expression-analysis-and-microdialysis-suggest-hypothalamic-triiodothyronine-t3-gates-daily-torpor-in-djungarian-hamsters-phodopus-sungorus
#17
Jonathan H H Bank, Ceyda Cubuk, Dana Wilson, Eddy Rijntjes, Julia Kemmling, Hanna Markovsky, Perry Barrett, Annika Herwig
Thyroid hormones play an important role in regulating seasonal adaptations of mammals. Several studies suggested that reduced availability of 3,3',5-triiodothyronine (T3) in the hypothalamus is required for the physiological adaptation to winter in Djungarian hamsters. We have previously shown that T3 is involved in the regulation of daily torpor, but it remains unclear, whether T3 affects torpor by central or peripheral mechanisms. To determine the effect of T3 concentrations within the hypothalamus in regulating daily torpor, we tested the hypothesis that low hypothalamic T3 metabolism would favour torpor and high T3 concentrations would not...
April 1, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28365357/chronic-kidney-disease-is-more-common-in-locally-advanced-renal-cell-carcinoma
#18
Sumi Dey, Zachary Hamilton, Sabrina L Noyes, Conrad M Tobert, Jacob Keeley, Ithaar H Derweesh, Brian R Lane
OBJECTIVE: To retrospectively evaluate clinical predictors of CKD in RCC patients to identify associations between patient- and tumor-specific factors with poorer renal function. Chronic kidney disease (CKD) and renal cell carcinoma (RCC) are inter-related, with 26-44% of RCC patients having concomitant CKD at diagnosis. METHODS: Institutional registries from SH and UCSD were queried for preoperative GFR and proteinuria status prior to radical or partial nephrectomy...
March 29, 2017: Urology
https://www.readbyqxmd.com/read/28361355/redox-status-alterations-during-the-competitive-season-in-%C3%A3-lite-soccer-players-focus-on-peripheral-leukocyte-derived-ros
#19
Matteo Becatti, Amanda Mannucci, Victoria Barygina, Gabriele Mascherini, Giacomo Emmi, Elena Silvestri, Daniel Wright, Niccolò Taddei, Giorgio Galanti, Claudia Fiorillo
It is well known that exercise training can deeply affect redox homeostasis by enhancing antioxidant defenses. However, exhaustive exercise can induce excessive reactive oxygen species (ROS) production, leading to oxidative stress-related tissue injury and impaired muscle contractility. Hence, ROS represent important signaling molecules whose level has to be maintained to preserve normal cellular function, but which can also accumulate in response to repetitive muscle contraction. In fact, low levels of oxidants have been suggested to be essential for muscle contraction...
March 30, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28359881/ku32-prevents-5-fluorouracil-induced-cognitive-impairment
#20
Michael J Sofis, David P Jarmolowicz, Sam V Kaplan, Rachel C Gehringer, Shea M Lemley, Brian S Blagg, Michael A Johnson
Chemotherapy induced cognitive impairment (i.e. Chemobrain) involves acute and long-term deficits in memory, executive function, and processing speed. Animal studies investigating these cognitive deficits have had mixed results, potentially due to variability in the complexity of behavioral tasks across experiments. Further, common chemotherapy treatments such as 5-Fluorouracil (5-FU) break down myelin integrity corresponding to hippocampal neurodegenerative deficits and mitochondrial dysfunction. There is little evidence, however, of pharmacological treatments that may target mitochondrial dysfunction...
March 27, 2017: Behavioural Brain Research
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