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https://www.readbyqxmd.com/read/28815443/endoscopic-ultrasound-as-a-pretreatment-clinical-staging-tool-for-gastric-cancer-association-with-pathology-and-outcome
#1
Ryan P Merkow, Gabriel Herrera, Debra A Goldman, Hans Gerdes, Mark A Schattner, Arnold J Markowitz, Vivian E Strong, Murray F Brennan, Daniel G Coit
BACKGROUND: Endoscopic ultrasound (EUS) is a guideline-recommended diagnostic test to estimate pretreatment clinical stage in gastric cancer. The impact of EUS to discriminate long-term outcomes has not been established. OBJECTIVES: The objectives of our study were to (1) evaluate the association between EUS and pathologic stage; (2) evaluate the ability of EUS to predict disease-specific survival (DSS); and (3) determine how neoadjuvant chemotherapy (NCT) affects these relationships...
August 16, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28814338/anti-nausea-effects-and-pharmacokinetics-of-ondansetron-maropitant-and-metoclopramide-in-a-low-dose-cisplatin-model-of-nausea-and-vomiting-in-the-dog-a-blinded-crossover-study
#2
Hannah Kenward, Jonathan Elliott, Terry Lee, Ludovic Pelligand
BACKGROUND: Nausea is a subjective sensation which is difficult to measure in non-verbal species. The aims of this study were to determine the efficacy of three classes of antiemetic drugs in a novel low dose cisplatin model of nausea and vomiting and measure change in potential nausea biomarkers arginine vasopressin (AVP) and cortisol. A four period cross-over blinded study was conducted in eight healthy beagle dogs of both genders. Dogs were administered 18 mg/m(2) cisplatin intravenously, followed 45 min later by a 15 min infusion of either placebo (saline) or antiemetic treatment with ondansetron (0...
August 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28812446/higher-dietary-intake-of-vitamin-d-may-influence-total-cholesterol-and-carbohydrate-profile-independent-of-body-composition-in-men-with-chronic-spinal-cord-injury
#3
Christopher Beal, Ashraf Gorgey, Pamela Moore, Nathan Wong, Robert A Adler, David Gater
STUDY DESIGN: A case-control design. OBJECTIVES: To determine the effects of dietary vitamin D intake on insulin sensitivity (Si), glucose effectiveness (Sg), and lipid profile in individuals with spinal cord injury (SCI). METHODS: 20 male, paraplegic (T3-L1) with chronic (> one year) motor complete SCI (AIS A or B) were recruited. Three-day dietary records were analyzed for dietary vitamin D (calciferol), and participants were assigned to one of two groups, a high vitamin D intake group and a low vitamin D intake group based on the mid-point of vitamin D frequency distribution...
August 16, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28807447/role-of-reactive-oxygen-species-during-low-intensity-pulsed-ultrasound-application-in-mc-3-t3-e1-pre-osteoblast-cell-culture
#4
Harmanpreet Kaur, Arno G Siraki, Hasan Uludağ, Douglas N Dederich, Patrick Flood, Tarek El-Bialy
We evaluated the activation of mitogen-activated protein kinase (MAPK) activation through reactive oxygen species (ROS) by application of low-intensity ultrasound (LIPUS) to MC-3 T3 E1 pre-osteoblasts. The cells were subjected to one LIPUS application for either 10 or 20 min, and the control group was exposed to a sham transducer. For ROS inhibition, 10 μM diphenylene iodonium (DPI) was added to the cells an hour before LIPUS application. Samples were collected 1, 3, 6, 12 and 24 h after LIPUS application, and cells were evaluated for ROS generation, cell viability, gene expression and MAPK activation by immunoblot analyses...
August 11, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28797455/prognostic-factors-and-occult-nodal-disease-in-mucoepidermoid-carcinoma-of-the-oral-cavity-and-oropharynx-an-analysis-of-the-national-cancer-database
#5
Mark A Ellis, Evan M Graboyes, Terry A Day, David M Neskey
OBJECTIVES: Mucoepidermoid carcinoma (MEC) is an uncommon malignancy that most commonly occurs in the parotid gland followed by the minor salivary glands of the upper aerodigestive tract, most notably in the oral cavity (OC) and oropharynx (OP). Because of its rarity, few studies have been performed that are specific to MEC within the OC and OP. The objective of this study is to describe the tumor characteristics and prognostic features for MEC of the OC and OP. MATERIALS AND METHODS: The National Cancer Database (NCDB) was used for this study...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28789931/clinical-analysis-of-primary-colorectal-signet-ring-cell-carcinoma
#6
REVIEW
ZhengZi Liang, DengGuo Yan, GuoSheng Li, HaiYu Cheng
The objective of the study was to investigate the clinicopathological features of primary colorectal signet-ring cell carcinoma. We retrospectively analyzed the clinical and survival data of 37 patients with primary colorectal signet-ring cell carcinoma. The mean survival time of patients in stage II, III, and IV were estimated using Student t test and the cumulative survival rates were estimated according to the method of Kaplan-Meier. The significance of the differences in survival rates were calculated using the log rank test...
July 8, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28777884/state-dependent-behavior-alters-endocrine-energy-relationship-implications-for-conservation-and-management
#7
Brett R Jesmer, Jacob R Goheen, Kevin L Monteith, Matthew J Kauffman
Glucocorticoids (GC) and triiodothyronine (T3) are two endocrine markers commonly used to quantify resource limitation, yet the relationships between these markers and the energetic state of animals has been studied primarily in small-bodied species in captivity. Free-ranging animals, however, adjust energy intake in accordance with their energy reserves, a behavior known as state-dependent foraging. Further, links between life-history strategies and metabolic allometries cause energy intake and energy reserves to be more strongly coupled in small animals relative to large animals...
August 4, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28773005/implant-stability-of-biological-hydroxyapatites-used-in-dentistry
#8
Maria Piedad Ramírez Fernández, Sergio A Gehrke, Patricia Mazón, Jose L Calvo-Guirado, Piedad N De Aza
The aim of the present study was to monitor implant stability after sinus floor elevation with two biomaterials during the first six months of healing by resonance frequency analysis (RFA), and how physico-chemical properties affect the implant stability quotient (ISQ) at the placement and healing sites. Bilateral maxillary sinus augmentation was performed in 10 patients in a split-mouth design using a bobine HA (BBM) as a control and porcine HA (PBM). Six months after sinus lifting, 60 implants were placed in the posterior maxilla...
June 12, 2017: Materials
https://www.readbyqxmd.com/read/28771444/radiotherapy-for-t3n0-glottic-carcinoma-without-cord-fixation-elective-nodal-irradiation-or-not
#9
Ryo Toya, Ryuji Murakami, Daizo Murakami, Tetsuo Saito, Tomohiko Matsuyama, Yutaka Toya, Yasuyuki Yamashita, Natsuo Oya
BACKGROUND: Although the T3 category has been changed in the sixth edition of the TNM staging system proposed by the Union for International Cancer Control (UICC), the appropriate clinical target volume (CTV) of elective nodal irradiation (ENI) for T3N0 glottic carcinoma without cord fixation, which was formerly treated as a T1-2N0 disease, is not fully discussed. MATERIALS AND METHODS: We retrospectively analyzed 64 patients staged or restaged as T3N0 disease without cord fixation...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28767337/prevalence-and-course-of-symptom-defined-ptsd-in-individuals-directly-or-indirectly-exposed-to-terror-a-longitudinal-study
#10
Marianne Bang Hansen, Marianne Skogbrott Birkeland, Alexander Nissen, Ines Blix, Øivind Solberg, Trond Heir
OBJECTIVE: It is well established that direct exposure to terrorism can result in posttraumatic stress disorder (PTSD). However, individuals indirectly exposed to terrorism may also develop symptoms of PTSD. This study examined the prevalence and course of symptom-defined PTSD in employees who were present and not present at the site of a workplace terror attack. METHODS: Survey data from ministerial employees were collected 10, 22, and 34 months after the 2011 bombing in the government district of Oslo...
2017: Psychiatry
https://www.readbyqxmd.com/read/28766133/prognostic-significance-of-neutrophil-lymphocyte-ratios-in-large-cell-neuroendocrine-carcinoma
#11
Masayuki Okui, Takashi Yamamichi, Ayaka Asakawa, Masahiko Harada, Makoto Saito, Hirotoshi Horio
OBJECTIVES: Large cell neuroendocrine carcinomas (LCNECs) are rare neuroendocrine pulmonary malignancies with poor survival. Towards the goal of identifying a useful prognostic marker for LCNEC, we examined the prognostic significance of the neutrophil-lymphocyte ratio (NLR) in LCNEC patients after complete resection. The NLR is a potential predictive indicator in other cancers and can be easily determined at low cost. METHODS: We retrospectively reviewed the perioperative clinical and laboratory data of patients who underwent complete resection for LCNEC between 1995 and 2014...
August 1, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28760596/serum-resistin-levels-inversely-associated-with-cardiovascular-risk-indices-in-type-2-diabetics-from-central-mexico
#12
Dania G Solis-Cano, Leonardo M Porchia, M Elba Gonzalez-Mejia, Ricardo Pérez-Fuentes, Guadalupe Ruiz-Vivanco, Adriana Nieva-Vazquez, Enrique Torres-Rasgado
AIMS: Since, resistin has been associated with coronary heart disease and with the progression of Type 2 Diabetes (T2D), our objective was to determine the correlation between resistin and cardiovascular risk (CVR) in subjects with increasing degrees of hyperglycemia. METHODS: Using a cross-sectional study design, the anthropometric and biochemical profiles were collected from 180 subjects from Puebla, Mexico. Subjects were separated into Normoglycemic (NGT), pre-diabetic (PT2D), or T2D...
July 25, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28755931/blood-plasma-traits-associated-with-genetic-merit-for-feed-utilization-in-holstein-cows
#13
C D Dechow, C R Baumrucker, R M Bruckmaier, J W Blum
The objective of this study was to evaluate the potential of selection for feed utilization on associated blood plasma metabolite and hormone traits. Dry matter intake (DMI) was recorded in 970 Holsteins from 11 commercial farms in Pennsylvania and used to derive dry matter efficiency (DME; fat-corrected milk yield/DMI), crude protein efficiency (CPE; protein yield/crude protein intake), and residual feed intake (RFI, defined as actual feed intake minus expected feed intake for maintenance and milk production, based on calculation of DMI adjusted for yield, body weight, and body condition score)...
July 26, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28755902/low-triiodothyronine-is-associated-with-elevation-of-n-terminal-pro-brain-natriuretic-peptide-nt-probnp-and-mortality-in-dialysis-patients
#14
María Del Carmen Prado-Uribe, María-de-Jesús Ventura, Marcela Ávila-Díaz, Carmen J Mora, Antonio Méndez-Durán, Diana Villanueva-Noches, Alejandra Cisneros, Begoña Ilabaca, Alfonso Cueto-Manzano, Fernando García-Contreras, Bengt Lindholm, Elvia García-López, Ramón Paniagua
BACKGROUND: Low thyroid hormone (TH) levels and myocardial damage are common in dialysis patients and are associated with mortality. However, little is known about the role of THs on myocardial damage as has been described in primary thyroid diseases. The aim of this study was to explore the potential relationship between low total triiodothyronine (total T3) and biomarkers of myocardial damage and the effect of their interaction on mortality, to ascertain if cardiovascular damage is the link between low THs and the risk of death in dialysis patients with CKD...
July 26, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28753577/diagnostic-potential-of-serum-exosomal-colorectal-neoplasia-differentially-expressed-long-non-coding-rna-crnde-p-and-microrna-217-expression-in-colorectal-carcinoma
#15
Bo Yu, Qiong Du, Huan Li, Hong-Yue Liu, Xuan Ye, Bin Zhu, Qing Zhai, Xin-Xiang Li
In this study, we investigated the diagnostic potential of serum exosomal colorectal neoplasia differentially expressed (CRNDE-p) long coding RNA and microRNA-217 in colorectal carcinoma (CRC). We detected high CRNDE-p and low miR-217 levels in exosomes released by multiple CRC cell lines into culture media as well as in sera from CRC xenograft mice and CRC patients. Conversely, we observed lower CRNDE-p and higher miR-217 levels in serum exosomes from post-chemotherapy than from pre-chemotherapy patient samples...
July 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28749194/results-of-preoperative-chemoradiotherapy-for-patients-with-advanced-cancer-of-the-nasal-cavity-and-paranasal-sinuses
#16
Erik Fernström, Jan Nyman, Eva Hammerlid, Erik Holmberg, Hedda Haugen-Cange, Karin Petruson, Edvard Abel, Thomas Björk-Eriksson
OBJECTIVES: Curative treatment of nasal cavity and paranasal sinus cancer is challenging due to the proximity to critical anatomical structures. The purpose of this study was to analyze the impact of trimodality therapy with preoperative chemotherapy and reduced-dose radiotherapy followed by organ-preserving surgery for treating patients with nasal cavity and paranasal sinus cancer. METHODS: This retrospective study included all 156 patients diagnosed with sinonasal cancer in western Sweden between 1986 and 2009...
July 27, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28748336/continuous-release-of-oregano-oil-effectively-and-safely-controls-varroa-destructor-infestations-in-honey-bee-colonies-in-a-northern-climate
#17
Qodratollah Sabahi, Hanan Gashout, Paul G Kelly, Ernesto Guzman-Novoa
The ectoparasitic mite Varroa destructor is responsible for the death of millions of honey bee (Apis mellifera) colonies worldwide. Testing potential miticide compounds with different delivery methods that effectively control V. destructor and have low toxicity for honey bees is crucial to manage this parasite in hives. We determined the varroacide efficacy of three natural compounds delivered to hives with three application methods over a 4-week period. Oxalic acid in a sucrose solution was applied impregnated in cardboard (T1)...
July 26, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28742507/severe-neurological-abnormalities-in-a-young-boy-with-impaired-thyroid-hormone-sensitivity-due-to-a-novel-mutation-in-the-mct8-gene
#18
Teresa Rego, Carmen Gomez Lado, Paloma Cabanas Rodríguez, Francisco Sousa Santos, Francisco Barros Angueira, Lidia Castro-Feijóo, Jesús Barreiro Conde, Manuel Castro-Gago
Monocarboxylate transporter 8 (MCT8) is an active and specific thyroid hormone transporter into neurons. MCT8 mutations cause an X-linked condition known as Allan-Herndon-Dudley syndrome and are characterized by impaired psychomotor development and typical abnormal thyroid function. We describe a 10-year-old boy with severe cognitive disability, axial hypotonia, spastic quadriplegia and sporadic dyskinetic episodes. He initially presented with thyroid dysfunction (high FT3, low rT3, low FT4 and normal TSH) and generalized retardation of the cerebral and cerebellar myelination in brain magnetic resonance imaging...
April 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28742421/comparison-of-30-mci-and-50-mci-i-131-doses-for-ablation-of-thyroid-remnant-in-papillary-thyroid-cancer-patients
#19
Xiao Yue Cai, Niranjan Vijayaratnam, Alexander J B McEwan, Rebecca Reif, Donald W Morrish
PURPOSE OF THE STUDY: To compare efficacy of thyroid remnant ablation using 30 mCi or 50 mCi 131-I in papillary thyroid cancer patients. MATERIALS AND METHODS: Five hundred and fifteen consecutive patients with Tumor-Node-Metastasis (TNM) stages T1-T3 N1/N0/NX receiving either 30 mCi or 50 mCi I-131 were analyzed for the effectiveness of remnant ablation using rhTSH-stimulated serum thyroglobulin. One hundred and five consecutive patients receiving 100 mCi I-131 were analyzed for the incidence of radiation thyroiditis and sialadenitis...
July 25, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28740904/disparities-in-staging-prostate-magnetic-resonance-imaging-utilization-for-nonmetastatic-prostate-cancer-patients-undergoing-definitive-radiation-therapy
#20
Ayobami Ajayi, Wei-Ting Hwang, Neha Vapiwala, Mark Rosen, Christina H Chapman, Stefan Both, Meera Shah, Xingmei Wang, Atu Agawu, Peter Gabriel, John Christodouleas, Zelig Tochner, Curtiland Deville
PURPOSE: There is growing evidence supporting incorporating multiparametric (mp) magnetic resonance imaging (MRI) scans into risk stratification, active surveillance, and treatment paradigms for prostate cancer. The purpose of our study was to determine whether demographic disparities exist in staging MRI utilization for prostate cancer patients. METHODS AND MATERIALS: An institutional database of 705 nonmetastatic prostate cancer patients treated with radiation therapy from 2005 through 2013 was used to identify patients undergoing versus not undergoing pretreatment diagnostic prostate mpMRI...
October 2016: Advances in Radiation Oncology
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