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Baha M. Sibai

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https://www.readbyqxmd.com/read/28059847/angiogenic-and-antiangiogenic-markers-for-prediction-and-risk-classification-of-preeclampsia
#1
Amol K Malshe, Baha M Sibai
Preeclampsia is a pregnancy-specific hypertensive disorder with multisystem involvement and is a significant cause of obstetric morbidity and mortality worldwide. A major issue in the treatment of preeclampsia stems from its still significant rates of misclassification and misdiagnosis. Angiogenic factors have been speculated as a possible diagnostic modality due to a perceived imbalance in angiogenesis in preeclampsia. Factors currently studied include soluble fms-like protein kinase 1 and placental growth factor...
January 4, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28059842/counseling-management-and-outcome-in-women-with-severe-preeclampsia-at-23-to-28-weeks-gestation
#2
Olaide A Ashimi Balogun, Baha M Sibai
Preeclampsia with severe features (SPE) remote from term remains a major cause of maternal morbidity and mortality worldwide. With increasing diagnosis of SPE remote from term and improved methods for monitoring maternal and fetal well-being, several challenges have been made regarding management of preeclampsia. We reviewed the scientific literature of the diagnosis and outcome of SPE before 28 weeks. On the basis of this review, we will present our recommendations on management of SPE before 28 weeks' gestation...
January 4, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28031980/obesity-epidemic-impact-from-preconception-to-postpartum
#3
REVIEW
Hind N Moussa, Mesk A Alrais, Mateo G Leon, Elizabeth L Abbas, Baha M Sibai
The obesity epidemic is on the rise throughout the USA and the world. Not only does it affect the general population but it also specifically poses unique threats to a woman's life in the antepartum, peripartum and postpartum periods. An increased BMI is associated with worse perinatal outcomes, including higher rates of preeclampsia (and other hypertensive disorders), macrosomia, other neonatal morbidities and gestational diabetes. Isolated maternal obesity and additional maternal diabetes predispose the infant to potential adult disease through fetal programming...
September 2016: Future Science OA
https://www.readbyqxmd.com/read/28031963/folic-acid-supplementation-what-is-new-fetal-obstetric-long-term-benefits-and-risks
#4
REVIEW
Hind N Moussa, Susan Hosseini Nasab, Ziad A Haidar, Sean C Blackwell, Baha M Sibai
The association between folic acid supplementation, prior to conception and/or during pregnancy and pregnancy outcomes, has been the subject of numerous studies. The worldwide recommendation of folic acid is at least 0.4 mg daily for all women of reproductive age, and 4-5 mg in high-risk women. In addition, evidence shows that folic acid supplementation could modulate other adverse pregnancy outcomes, specifically, in pregnancies complicated by seizure disorders, preeclampsia, anemia, fetal growth restriction and autism...
June 2016: Future Science OA
https://www.readbyqxmd.com/read/28031961/fetal-origins-of-autism-spectrum-disorders-the-non-associated-maternal-factors
#5
REVIEW
Hind N Moussa, Anand Srikrishnan, Sean C Blackwell, Pramod Dash, Baha M Sibai
AIM: Several population-based studies have been conducted to determine whether maternal exposures are involved in the pathophysiology of autism spectrum disorder (ASD). We review these studies and describe the factors not associated with increased risk for ASD development. METHODS: We identified studies describing associations between maternal exposures and ASD development. These studies include the Childhood Autism Risks from Genetics and the Environment, Nurses' Health Study II, and the Swedish population registry...
June 2016: Future Science OA
https://www.readbyqxmd.com/read/28005594/controversies-regarding-diagnosis-and-treatment-of-severe-hypertension-in-pregnancy
#6
John R Barton, Baha M Sibai
The objective of management of severe hypertension in pregnancy is not for the return of normal blood pressure but rather reduction of blood pressure to a level associated with a decreased risk of end-organ damage including cerebral, cardiac, or renal dysfunction. The parenteral agents labetalol and hydralazine are currently the most widely recommended antihypertensive agents for acute reductions of elevated blood pressure related to preeclampsia. Overcorrection of blood pressure with any antihypertensive agent is possible resulting in reduced uteroplacental blood flow, but is more likely to be encountered in patients <32 weeks' gestation and in those whose fetuses have intrauterine growth retardation...
December 21, 2016: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28005591/hypertension-in-pregnancy
#7
Baha M Sibai
No abstract text is available yet for this article.
December 21, 2016: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28005590/low-molecular-weight-heparin-for-the-prevention-of-placenta-mediated-pregnancy-complications
#8
Bassam Haddad, Edouard Lecarpentier, Cyril Touboul, Baha M Sibai
During the past decade, prophylactic doses of low-molecular-weight heparin (LMWH) have been suggested to decrease the risk of placental-mediated complications. Herein, we review the prospective randomized trials that addressed the usefulness of LMWH in preventing placental-mediated complications in high-risk women. Inclusion criteria and results of these trials are heterogeneous. Unlike older trials (3 of 4 are single center), recent trials (all are multicenter) do not show beneficial effect of LMWH. There is certainly a need of complementary research before stating on the usefulness of LMWH in the prevention of placenta-mediated pregnancy complications in women at high risk...
December 21, 2016: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28005588/chronic-hypertension-in-pregnancy-diagnosis-management-and-outcomes
#9
Nana-Ama E Ankumah, Baha M Sibai
Chronic hypertension affects up to 5% of pregnancies. Women can be stratified into low-risk or high-risk chronic hypertension based on baseline laboratory and diagnostic work-up, comorbid conditions, and outcomes in prior pregnancies. Pregnancies complicated by chronic hypertension are at risk for increased adverse maternal and neonatal outcomes including superimposed preeclampsia, fetal growth restriction, placental abruption, and perinatal death. Mainstays of management include blood pressure control, close monitoring for development of superimposed preeclampsia, serial ultrasound assessment of fetal growth, and antenatal testing after 32 weeks...
December 21, 2016: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28005587/diagnosis-and-management-of-hellp-syndrome-complicated-by-liver-hematoma
#10
Agnès Ditisheim, Baha M Sibai
Subcapsular liver hematoma is a rare but potentially life-threatening complication of preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. It may present with nonspecific signs and symptoms, none of which are diagnostic, and can mimic pulmonary embolism of cholecystitis. There is no consensus on the management of subcapsular liver hematoma. Unruptured liver hematoma can be conservatively managed. When rupture occurs, surgical, endovascular approaches and, rarely, liver transplantation, may be required...
December 21, 2016: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27921517/effect-of-partial-compliance-on-the-prevention-of-recurrent-preterm-birth-in-women-receiving-weekly-17-alpha-hydroxyprogesterone-caproate-injections
#11
Ziad A Haidar, Hind N Moussa, Susan Hosseini Nasab, Baha M Sibai
PURPOSE: To analyze the effect of partial compliance on preterm birth (PTB) prevention among women with previous PTB and receiving 17 alpha-hydroxyprogesterone caproate (17-OHPC). STUDY DESIGN: This is a secondary analysis of a multicenter trial for the prevention of recurrent PTB. Women with prior PTB were randomly assigned between 15 0/7 and 20 3/7 weeks to weekly injections of either 17-OHPC or placebo. Full 100% compliance (group 1) was compared to 40-80% (group 2)...
December 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27689239/treatment-options-for-hypertension-in-pregnancy-and-puerperium
#12
Farah H Amro, Hind N Moussa, Olaide A Ashimi, Baha M Sibai
Hypertensive disorders have become increasingly prevalent and complicate an increasing number of pregnancies. Therefore it is essential that the medications used to treat these disorders be well understood. Furthermore the management is complicated by special consideration needed for the physiologic changes of pregnancy as well as the consideration for possible adverse fetal effects. Areas covered: We performed a review of the scientific literature of medications used to treat hypertensive disorders in pregnancy...
December 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27638982/successful-management-of-a-periviable-pregnancy-with-morbidly-adherent-placenta-after-uterine-rupture
#13
Ziad A Haidar, Patricia C Vowels, Hind N Moussa, Baha M Sibai
BACKGROUND: Although rare, trauma in pregnancy can cause uterine rupture. In a periviable pregnancy, uterine rupture can lead to premature delivery and significant morbidity. CASE: A 29-year-old woman with four prior CSs presented with uterine rupture and a protruding morbidly adherent placenta at 23+4 weeks of gestation. Since the pregnancy was highly desired, the defect was repaired and the decision made to continue with the pregnancy. The patient presented at 29+3 weeks of gestation with preterm labour and subsequently delivered a healthy male infant of 1130 grams...
August 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27607853/pharmacologic-thromboprophylaxis-in-obstetrics-broader-use-demands-better-data
#14
Baha M Sibai, Dwight J Rouse
No abstract text is available yet for this article.
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27606778/pregnancy-outcomes-in-women-with-preeclampsia-superimposed-on-chronic-hypertension-with-and-without-severe-features
#15
Hind N Moussa, Mateo G Leon, Ana Marti, Alissar Chediak, Claudia Pedroza, Sean C Blackwell, Baha M Sibai
Objective The American Congress of Obstetricians and Gynecologists (ACOG) task force on hypertension in pregnancy introduced a new definition of superimposed preeclampsia (SIP) adding severe features (SF) as new criteria to define severe disease. They also recommended that those with SIP be delivered ≥ 37 weeks, whereas those with SF be delivered ≤ 34 weeks. Our aim was to investigate the validity of this new definition by comparing adverse pregnancy outcomes in SIP with (SIP-SF) and without SF (SIP)...
September 8, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27571482/biomarkers-for-prediction-risk-stratification-and-ruling-out-preeclampsia-what-are-the-appropriate-goals-and-objectives
#16
John R Barton, Baha M Sibai
No abstract text is available yet for this article.
August 29, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27565786/adverse-effect-of-high-fat-diet-on-metabolic-programming-in-offspring-born-to-a-murine-model-of-maternal-hypertension
#17
Monica Longo, Jerrie S Refuerzo, Lovepreet Mann, Mateo Leon, Hind N Moussa, Baha M Sibai, Sean C Blackwell
BACKGROUND: We previously reported that offspring heterozygous mice partially lacking endothelial nitric oxide synthase (eNOS) gene, and born to hypertensive eNOS(-/-) Knockout mother, are hypertensive. We hypothesized that those offspring when placed on high-fat diet (HFD) will undergo altered metabolic programming increasing their risk for developing metabolic syndrome. METHODS: eNOS(-/-)KO and wild-type mice (eNOS(+/+)WT) were cross-bred to produce heterozygous offspring: maternal heterozygous (Mat, eNOS(-/+)), born from hypertensive eNOS(-/-)KO mothers; and paternal heterozygous (Pat, eNOS(-/+)), born from normotensive WT mothers...
August 26, 2016: American Journal of Hypertension
https://www.readbyqxmd.com/read/27500336/antenatal-corticosteroids-for-the-prevention-of-respiratory-distress-syndrome-in-premature-twins
#18
Oscar A Viteri, Sean C Blackwell, Suneet P Chauhan, Jerrie S Refuerzo, Claudia Pedroza, Ximena C Salazar, Baha M Sibai
OBJECTIVE: To estimate whether antenatal corticosteroids before 34 weeks of gestation are associated with reduced incidence of respiratory distress syndrome (RDS) and composite neonatal morbidity in preterm twins. METHODS: This was a secondary analysis of a multicenter randomized trial for the prevention of preterm birth in multiple gestations. All liveborn, nonanomalous twins delivered between 24 0/7 and 36 6/7 weeks of gestation were included. Neonatal outcomes were compared between women who received antenatal corticosteroids and those who did not...
September 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27400002/early-compared-with-delayed-physician-rounds-on-patient-satisfaction-of-postpartum-women-a-randomized-controlled-trial
#19
Robyn P Roberts, Sean C Blackwell, Kelly M Brown, Claudia Pedroza, Baha M Sibai, Jon E Tyson
OBJECTIVE: To investigate whether delayed timing of physician rounds improves patient satisfaction for postpartum women. METHODS: Women were randomized to early (5-7 AM) or delayed (8-10 AM) physician rounding. Women with stillbirth, high-risk pregnancy, or complications precluding delayed rounding were excluded. At discharge, women completed a modified Hospital Consumer Assessment of Healthcare Providers and Systems survey. The primary outcome was rating of the hospital...
August 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27364991/transglutaminase-is-a-critical-link-between-inflammation-and-hypertension
#20
Renna Luo, Chen Liu, Serra E Elliott, Wei Wang, Nicholas Parchim, Takayuki Iriyama, Patrick S Daugherty, Lijian Tao, Holger K Eltzschig, Sean C Blackwell, Baha M Sibai, Rodney E Kellems, Yang Xia
BACKGROUND: The pathogenesis of essential hypertension is multifactorial with different underlying mechanisms contributing to disease. We have recently shown that TNF superfamily member 14 LIGHT (an acronym for homologous to lymphotoxins, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes, also known as TNFSF14) induces hypertension when injected into mice. Research reported here was undertaken to examine the role of transglutaminase (TGase) in LIGHT-induced hypertension...
June 30, 2016: Journal of the American Heart Association
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