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Roberto Romero

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https://www.readbyqxmd.com/read/29766169/a-new-anthraquinoid-ligand-for-the-iron-catalyzed-hydrosilylation-of-carbonyl-compounds-at-room-temperature-new-insights-and-kinetics
#1
Álvaro Raya-Barón, Carmen P Galdeano-Ruano, Pascual Oña-Burgos, Antonio Rodríguez-Diéguez, Robert Langer, Rosalía López-Ruiz, Roberto Romero-González, Istemi Kuzu, Ignacio Fernández
The reaction of 1-((2-(pyridin-2-yl)ethyl)amino)anthraquinone with either Fe(HMDS)2 or Li(HMDS)/FeCl2 allowed the preparation of a new anthraquinoid-based iron(ii) complex active in the hydrosilylations of carbonyls. The new complex Fe(2)2 was characterized by single-crystal X-ray diffraction, infrared spectroscopy, NMR, and high resolution mass spectrometry (electrospray ionization). Superconducting quantum interference device (SQUID) magnetometry established no spin crossover behavior with an S = 2 state at room temperature...
May 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29726582/extracellular-vesicles-generated-by-placental-tissues-ex-vivo-a-transport-system-for-immune-mediators-and-growth-factors
#2
Wendy Fitzgerald, Nardhy Gomez-Lopez, Offer Erez, Roberto Romero, Leonid Margolis
PROBLEM: To study the mechanisms of placenta function and the role of extracellular vesicles (EVs) in pregnancy, it is necessary to develop an ex vivo system that retains placental cytoarchitecture and the primary metabolic aspects, in particular the release of EVs and soluble factors. Here, we developed such a system and investigated the pattern of secretion of cytokines, growth factors, and extracellular vesicles by placental villous and amnion tissues ex vivo. METHODS OF STUDY: Placental villous and amnion explants were cultured for 2 weeks at the air/liquid interface and their morphology and the released cytokines and EVs were analyzed...
May 4, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29695455/alloreactive-fetal-t-cells-promote-uterine-contractility-in-preterm-labor-via-ifn-%C3%AE-and-tnf-%C3%AE
#3
Michela Frascoli, Lacy Coniglio, Russell Witt, Cerine Jeanty, Shannon Fleck-Derderian, Dana E Myers, Tzong-Hae Lee, Sheila Keating, Michael P Busch, Philip J Norris, Qizhi Tang, Giovanna Cruz, Lisa F Barcellos, Nardhy Gomez-Lopez, Roberto Romero, Tippi C MacKenzie
Healthy pregnancy is the most successful form of graft tolerance, whereas preterm labor (PTL) may represent a breakdown in maternal-fetal tolerance. Although maternal immune responses have been implicated in pregnancy complications, fetal immune responses against maternal antigens are often not considered. To examine the fetal immune system in the relevant clinical setting, we analyzed maternal and cord blood in patients with PTL and healthy term controls. We report here that the cord blood of preterm infants has higher amounts of inflammatory cytokines and a greater activation of dendritic cells...
April 25, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29669263/localized-conformational-changes-trigger-the-ph-induced-fibrillogenesis-of-an-amyloidogenic-%C3%AE-light-chain-protein
#4
Isabel Velázquez López, Gilberto Valdés-García, Sergio Romero Romero, Roberto Maya Martínez, Ana I Leal-Cervantes, Miguel Costas, Rosana Sánchez-López, Carlos Amero, Nina Pastor, D Alejandro Fernández Velasco
Solvent conditions modulate the expression of the amyloidogenic potential of proteins. In this work the effect of pH on the fibrillogenic behavior and the conformational properties of 6aJL2, a model protein of the highly amyloidogenic variable light chain λ6a gene segment, was examined. Ordered aggregates showing the ultrastructural and spectroscopic properties observed in amyloid fibrils were formed in the 2.0-8.0 pH range. At pH <3.0 a drastic decrease in lag time and an increase in fibril formation rate were found...
April 15, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29659586/supply-side-interventions-to-improve-health-findings-from-the-salud-mesoam%C3%A3-rica-initiative
#5
Ali H Mokdad, Erin B Palmisano, Paola Zúñiga-Brenes, Diego Ríos-Zertuche, Casey K Johanns, Alexandra Schaefer, Sima S Desai, Annie Haakenstad, Marielle C Gagnier, Claire R McNellan, Danny V Colombara, Sonia López Romero, Leolin Castillo, Benito Salvatierra, Bernardo Hernandez, Miguel Betancourt-Cravioto, Ricardo Mujica-Rosales, Ferdinando Regalia, Roberto Tapia-Conyer, Emma Iriarte
BACKGROUND: Results-based aid (RBA) is increasingly used to incentivize action in health. In Mesoamerica, the region consisting of southern Mexico and Central America, the RBA project known as the Salud Mesoamérica Initiative (SMI) was designed to target disparities in maternal and child health, focusing on the poorest 20% of the population across the region. METHODS AND FINDINGS: Data were first collected in 365 intervention health facilities to establish a baseline of indicators...
2018: PloS One
https://www.readbyqxmd.com/read/29627412/behavior-of-quizalofop-p-and-its-commercial-products-in-water-by-liquid-chromatography-coupled-to-high-resolution-mass-spectrometry
#6
Rosalía López-Ruiz, Roberto Romero-González, José Luis Martínez Vidal, Antonia Garrido Frenich
A degradation study of quizalofop-p and its commercial products (quizalofop-p-ethyl, quizalofop-p-tefuryl and propaquizafop) in water samples has been performed using ultra high-performance liquid chromatography coupled to Orbitrap mass spectrometry (UHPLC-Orbitrap-MS). CHHQ (dihydroxychloroquinoxalin), CHQ (6-chloroquinoxalin-2-ol) and PPA ((R)-2-(4-hydroxyphenoxy)propionicacid) were the main metabolites of this active substance (quizalofop-p) in water. The degradation of the parent compound has been monitored in distilled water...
April 5, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29618000/effect-of-clarification-ph-of-sorghum-juice-on-the-composition-of-essential-nutrients-for-fermentation
#7
Marcos Antonio Durán, Karina Dantur, Roberto Marcelo Ruiz, Eduardo Raul Romero, Silvia Zossi, Carlos Gusils
The growing demand to replace fossil fuels with renewable alternatives has generated an urgent and imminent global need to find new non-fossil sources. Sweet sorghum is widely recognized as a highly promising biomass energy crop with particular potential to complement sugarcane for ethanol production. Our aim in this study was to evaluate the influence of pH during the clarification method on the composition of essential nutrients in the sorghum juice and how this affects the efficiency of the ethanol fermentation process...
March 29, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29604400/arabidopsis-swc4-binds-dna-and-recruits-the-swr1-complex-to-modulate-histone-h2a-z-deposition-at-key-regulatory-genes
#8
Ángeles Gómez-Zambrano, Pedro Crevillén, José M Franco-Zorrilla, Juan A López, Jordi Moreno-Romero, Pawel Roszak, Juan Santos-González, Silvia Jurado, Jesús Vázquez, Claudia Köhler, Roberto Solano, Manuel Piñeiro, José A Jarillo
Deposition of the H2A.Z histone variant by the SWR1 complex (SWR1-C) in regulatory regions of specific loci modulates transcription. Characterization of Arabidopsis thaliana mutations in homologs of the yeast SWR1-C has revealed a role for H2A.Z exchange in a variety of developmental processes; nevertheless, the exact composition of the plant SWR1-C and how it is recruited to target genes remains to be established. Here we show that SWC4, the Arabidopsis homolog of the yeast SANT domain protein Swc4/Eaf2, is a DNA-binding protein that interacts with SWR1-C subunits...
March 28, 2018: Molecular Plant
https://www.readbyqxmd.com/read/29603310/fetal-intelligent-navigation-echocardiography-fine-detects-98-of-congenital-heart-disease
#9
Lami Yeo, Suchaya Luewan, Roberto Romero
OBJECTIVE: Fetal intelligent navigation echocardiography (FINE) is a novel method that automatically generates and displays 9 standard fetal echocardiographic views in normal hearts by applying intelligent navigation technology to spatiotemporal image correlation (STIC) volume data sets. The main objective was to determine the sensitivity and specificity of FINE in the prenatal detection of congenital heart disease (CHD). METHODS: A case-control study was conducted in 50 fetuses with a broad spectrum of CHD (cases) and 100 fetuses with normal hearts (controls) in the second and third trimesters...
March 30, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29602570/successful-optimization-of-adalimumab-therapy-in-refractory-uveitis-due-to-beh%C3%A3-et-s-disease
#10
José Luis Martín-Varillas, Vanesa Calvo-Río, Emma Beltrán, Juan Sánchez-Bursón, Marina Mesquida, Alfredo Adán, María Victoria Hernandez, Marisa Hernández Garfella, Elia Valls Pascual, Lucía Martínez-Costa, Agustí Sellas-Fernández, Miguel Cordero-Coma, Manuel Díaz-Llopis, Roberto Gallego, David Salom, Norberto Ortego, José L García-Serrano, José-Luis Callejas-Rubio, José M Herreras, Ángel García-Aparicio, Olga Maíz, Ana Blanco, Ignacio Torre, David Díaz-Valle, Esperanza Pato, Elena Aurrecoechea, Miguel A Caracuel, Fernando Gamero, Enrique Minguez, Carmen Carrasco-Cubero, Alejandro Olive, Julio Vázquez, Oscar Ruiz-Moreno, Javier Manero, Santiago Muñoz-Fernández, Myriam Gandía Martinez, Esteban Rubio-Romero, F Javier Toyos-Sáenz de Miera, Francisco Javier López Longo, Joan M Nolla, Marcelino Revenga, Carmen González-Vela, Javier Loricera, Belén Atienza-Mateo, Rosalía Demetrio-Pablo, José Luis Hernández, Miguel A González-Gay, Ricardo Blanco
PURPOSE: To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behçet disease (BD) who achieved remission after the use of this biologic agent. DESIGN: Open-label multicenter study of ADA-treated patients with BD uveitis refractory to conventional immunosuppressants. SUBJECTS: Sixty-five of 74 patients with uveitis due to BD, who achieved remission after a median ADA duration of 6 (range, 3-12) months...
March 27, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29598980/a-profile-of-dennis-lo-dm-dphil-frcp-frcpath-frs
#11
EDITORIAL
Roberto Romero
No abstract text is available yet for this article.
April 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29558795/colonization-of-electrospun-polycaprolactone-fibers-by-relevant-pathogenic-bacterial-strains
#12
Carlos Rumbo, Juan Antonio Tamayo-Ramos, M Federica Caso, Antonio Rinaldi, Lorena Romero-Santacreu, Roberto Quesada, Santiago Cuesta
Electrospun biodegradable polymers have emerged as promising materials for their applications in several fields, including biomedicine and food industry. For this reason, the susceptibility of these materials to be colonized by different pathogens is a critical issue for public health, and their study can provide future knowledge to develop new strategies against bacterial infections. In this work, the ability of three pathogenic bacterial species ( Pseudomonas aeruginosa, Acinetobacter baumannii and Listeria monocytogenes) to adhere and form biofilm in electrospun polycaprolactone (PCL) microfibrous meshes was investigated...
March 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29556588/human-blood-gene-signature-as-a-marker-for-smoking-exposure-computational-approaches-of-the-top-ranked-teams-in-the-sbv-improver-systems-toxicology-challenge
#13
Adi L Tarca, Xiaofeng Gong, Roberto Romero, Wenxin Yang, Zhongqu Duan, Hao Yang, Chengfang Zhang, Peixuan Wang
Crowdsourcing has emerged as a framework to address methodological challenges in omics data analysis and assess the extent to which omics data are predictive of phenotypes of interest. The sbv IMPROVER Systems Toxicology Challenge was designed to leverage crowdsourcing to determine whether human blood gene expression levels are informative of current and past smoking. Participating teams were invited to use a training gene expression dataset to derive parsimonious models (up to 40 genes) that can accurately classify subjects into exposure groups: smokers, former smokers that quit for at least one year, and never-smokers...
February 2018: Computational Toxicology
https://www.readbyqxmd.com/read/29556587/species-translatable-blood-gene-signature-as-a-marker-of-exposure-to-smoking-computational-approaches-of-the-top-ranked-teams-in-the-sbv-improver-systems-toxicology-challenge
#14
Ömer Sinan Saraç, Rahul Kumar, Sandeep Kumar Dhanda, Ali Tuğrul Balcı, İsmail Bilgen, Roberto Romero, Adi L Tarca
Crowdsourcing has been used to address computational challenges in systems biology and assess translation of findings across species. Sub-challenge 2 of the sbv IMPROVER Systems Toxicology Challenge was designed to determine whether a common set of genes can be used to identify exposure to cigarette smoke in both human and mouse. Participating teams used a training set of human and mouse blood gene expression data to derive parsimonious models (up to 40 genes) that classify subjects into exposure groups: smokers, former smokers, and never-smokers...
February 2018: Computational Toxicology
https://www.readbyqxmd.com/read/29545452/asymptomatic-coronary-artery-calcifications-in-men-with-systemic-lupus-erythematosus
#15
Juanita Romero-Díaz, Roberto Iván Acosta-Hernández, Sergio Criales-Vera, Erick Kimura-Hayama, Maricruz Domínguez-Quintana, Rocío Morán-Contla, Carlos Núñez-Alvarez, Pilar Lara-Reyes, Carlos Aguilar-Salinas, Jorge Sánchez-Guerrero
OBJECTIVE: To determine whether the prevalence and extent of asymptomatic coronary artery atherosclerosis are increased in men with systemic lupus erythematosus (SLE) compared with age- and sex-matched controls, and to define the associated risk factors. METHODS: Ninety-five patients with SLE (mean ± SD age, 34.7 ± 10.1 yrs) and 100 control subjects (age 34.8 ± 9.7 yrs) with no history of coronary artery disease were screened for coronary artery calcification using multidetector computed tomography...
May 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29518927/smart-sound-processing-for-defect-sizing-in-pipelines-using-emat-actuator-based-multi-frequency-lamb-waves
#16
Joaquín García-Gómez, Roberto Gil-Pita, Manuel Rosa-Zurera, Antonio Romero-Camacho, Jesús Antonio Jiménez-Garrido, Víctor García-Benavides
Pipeline inspection is a topic of particular interest to the companies. Especially important is the defect sizing, which allows them to avoid subsequent costly repairs in their equipment. A solution for this issue is using ultrasonic waves sensed through Electro-Magnetic Acoustic Transducer (EMAT) actuators. The main advantage of this technology is the absence of the need to have direct contact with the surface of the material under investigation, which must be a conductive one. Specifically interesting is the meander-line-coil based Lamb wave generation, since the directivity of the waves allows a study based in the circumferential wrap-around received signal...
March 7, 2018: Sensors
https://www.readbyqxmd.com/read/29511268/publisher-correction-tlr4-mediated-placental-pathology-and-pregnancy-outcome-in-experimental-malaria
#17
Renato Barboza, Flávia Afonso Lima, Aramys Silva Reis, Oscar Javier Murillo, Erika Paula Machado Peixoto, Carla Letícia Bandeira, Wesley Luzetti Fotoran, Luis Roberto Sardinha, Gerhard Wunderlich, Estela Bevilacqua, Maria Regina D'Império Lima, José Maria Alvarez, Fabio Trindade Maranhão Costa, Lígia Antunes Gonçalves, Sabrina Epiphanio, Claudio Romero Farias Marinho
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
March 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29500850/the-immunophenotype-of-amniotic-fluid-leukocytes-in-normal-and-complicated-pregnancies
#18
Nardhy Gomez-Lopez, Roberto Romero, Yi Xu, Derek Miller, Yaozhu Leng, Bogdan Panaitescu, Pablo Silva, Jonathan Faro, Ali Alhousseini, Navleen Gill, Sonia S Hassan, Chaur-Dong Hsu
PROBLEM: The immune cellular composition of amniotic fluid is poorly understood. Herein, we determined: 1) the immunophenotype of amniotic fluid immune cells during the second and third trimester in the absence of intra-amniotic infection/inflammation; 2) whether amniotic fluid T cells and ILCs display different phenotypical characteristics to that of peripheral cells; and 3) whether the amniotic fluid immune cells are altered in women with intra-amniotic infection/inflammation. METHOD OF STUDY: Amniotic fluid samples (n = 57) were collected from 15 to 40 weeks of gestation in women without intra-amniotic infection/inflammation...
April 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29481820/essential-tremor-quantification-based-on-the-combined-use-of-a-smartphone-and-a-smartwatch-the-netmd-study
#19
Roberto López-Blanco, Miguel A Velasco, Antonio Méndez-Guerrero, Juan Pablo Romero, María Dolores Del Castillo, J Ignacio Serrano, Julián Benito-León, Félix Bermejo-Pareja, Eduardo Rocon
BACKGROUND: The use of wearable technology is an emerging field of research in movement disorders. This paper introduces a clinical study to evaluate the feasibility, clinical correlation and reliability of using a system based in smartwatches to quantify tremor in essential tremor (ET) patients and check its acceptance as clinical monitoring tool. NEW METHOD: The system is based on a commercial smartwatch and an Android smartphone. An investigational Android application controls the process of recording raw data from the smartwatch three-dimensional gyroscopes...
June 1, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29457302/innate-lymphoid-cells-at-the-human-maternal-fetal-interface-in-spontaneous-preterm-labor
#20
Yi Xu, Roberto Romero, Derek Miller, Pablo Silva, Bogdan Panaitescu, Kevin R Theis, Afrah Arif, Sonia S Hassan, Nardhy Gomez-Lopez
PROBLEM: Pathological inflammation is causally linked to preterm labor and birth, the leading cause of neonatal morbidity and mortality worldwide. Our aims were to investigate whether (i) the newly described family of innate lymphoid cells (ILCs) was present at the human maternal-fetal interface and (ii) ILC inflammatory subsets were associated with the pathological process of preterm labor. METHODS OF STUDY: Decidual leukocytes were isolated from women with preterm or term labor as well as from gestational age-matched non-labor controls...
February 19, 2018: American Journal of Reproductive Immunology: AJRI
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