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Roberto Romero

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https://www.readbyqxmd.com/read/28802917/aerobic-exercise-in-adolescence-results-in-an-increase-of-neuronal-and-non-neuronal-cells-and-in-mtor-overexpression-in-the-cerebral-cortex-of-rats
#1
Angélica Begatti Victorino, Fernando Tadeu Serra, Pâmella Pimentel Piñero, Alexandre Aparecido de Almeida, Glauber Menezes Lopim, Ivair Matias Junior, Helio Rubens Machado, Roberto Lent, Francisco Romero Cabral, Fernando Gomez-Pinilla, Ricardo Mario Arida, Sérgio Gomes da Silva
Better cognitive performance and greater cortical and hippocampal volume have been observed in individuals who undertook aerobic exercise during childhood and adolescence. One possible explanation for these beneficial effects is that juvenile physical exercise enables better neural development and hence more cells and neuronal circuitries. It is probable that such effects occur through intracellular signaling proteins associated with cell growth, proliferation and survival. Based on this information, we evaluated the number of neuronal and non-neuronal cells using isotropic fractionation and the expression and activation of intracellular proteins (ERK, CREB Akt, mTOR and p70S6K) in the cerebral cortex and hippocampal formation of the rats submitted to a physical exercise program on a treadmill during adolescence...
August 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28797045/epidemiology-of-bovine-brucellosis-in-costa-rica-lessons-learned-from-failures-in-the-control-of-the-disease
#2
Gabriela Hernández-Mora, Nazareth Ruiz-Villalobos, Roberto Bonilla-Montoya, Juan-José Romero-Zúniga, Julio Jiménez-Arias, Rocío González-Barrientos, Elías Barquero-Calvo, Carlos Chacón-Díaz, Norman Rojas, Esteban Chaves-Olarte, Caterina Guzmán-Verri, Edgardo Moreno
Brucellosis, caused by Brucella abortus is a major disease of cattle and a zoonosis. In order to estimate the bovine brucellosis prevalence in Costa Rica (CR), a total 765 herds (13078 bovines) from six regions of CR were randomly sampled during 2012-2013. A non-random sample of 7907 herds (532199 bovines) of the six regions, arriving for diagnoses during 2014-2016 to the Costa Rican Animal Health Service was also studied. The prevalence estimated by Rose Bengal test (RBT) ranged from 10.5%-11.4%; alternatively, the prevalence estimated by testing the RBT positives in iELISA, ranged from 4...
2017: PloS One
https://www.readbyqxmd.com/read/28793352/brucellosis-in-mammals-of-costa-rica-an-epidemiological-survey
#3
Gabriela Hernández-Mora, Roberto Bonilla-Montoya, Osvaldo Barrantes-Granados, Andrea Esquivel-Suárez, Danilo Montero-Caballero, Rocío González-Barrientos, Zeanne Fallas-Monge, José David Palacios-Alfaro, Mario Baldi, Elena Campos, Grettel Chanto, Elías Barquero-Calvo, Carlos Chacón-Díaz, Esteban Chaves-Olarte, Caterina Guzmán Verri, Juan-José Romero-Zúñiga, Edgardo Moreno
Brucellosis has been an endemic disease of cattle and humans in Costa Rica since the beginning of XX century. However, brucellosis in sheep, goats, pigs, water buffaloes, horses and cetaceans, has not been reported in the country. We have performed a brucellosis survey in these host mammal species, from 1999-2016. In addition, we have documented the number of human brucellosis reported cases, from 2003-2016. The brucellosis seroprevalence in goat and sheep herds was 0.98% and 0.7% respectively, with no Brucella isolation...
2017: PloS One
https://www.readbyqxmd.com/read/28758123/peripheral-antinociception-induced-by-aripiprazole-is-mediated-by-the-opioid-system
#4
Renata Cristina Mendes Ferreira, Ana Flávia Almeida-Santos, Igor Dimitri Gama Duarte, Daniele C Aguiar, Fabricio A Moreira, Thiago Roberto Lima Romero
BACKGROUND: Aripiprazole is an antipsychotic drug used to treat schizophrenia and related disorders. Our previous study showed that this compound also induces antinociceptive effects. The present study aimed to assess the participation of the opioid system in this effect. METHODS: Male Swiss mice were submitted to paw pressure test and hyperalgesia was induced by intraplantar injection of prostaglandin E2 (PGE2, 2 μg). Aripiprazole was injected 10 min before the measurement...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28751717/distribution-and-genotype-phenotype-correlation-of-gdap1-mutations-in-spain
#5
Rafael Sivera, Marina Frasquet, Vincenzo Lupo, Tania García-Sobrino, Patricia Blanco-Arias, Julio Pardo, Roberto Fernández-Torrón, Adolfo López de Munain, Celedonio Márquez-Infante, Liliana Villarreal, Pilar Carbonell, Ricard Rojas-García, Sonia Segovia, Isabel Illa, Anna Lia Frongia, Andrés Nascimento, Carlos Ortez, María Del Mar García-Romero, Samuel Ignacio Pascual, Ana Lara Pelayo-Negro, José Berciano, Antonio Guerrero, Carlos Casasnovas, Ana Camacho, Jesús Esteban, María José Chumillas, Marisa Barreiro, Carmen Díaz, Francesc Palau, Juan Jesús Vílchez, Carmen Espinós, Teresa Sevilla
Mutations in the GDAP1 gene can cause Charcot-Marie-Tooth disease. These mutations are quite rare in most Western countries but not so in certain regions of Spain or other Mediterranean countries. This cross-sectional retrospective multicenter study analyzed the clinical and genetic characteristics of patients with GDAP1 mutations across Spain. 99 patients were identified, which were distributed across most of Spain, but especially in the Northwest and Mediterranean regions. The most common genotypes were p...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747528/embryo-implantation-evolved-from-an-ancestral-inflammatory-attachment-reaction
#6
Oliver W Griffith, Arun R Chavan, Stella Protopapas, Jamie Maziarz, Roberto Romero, Gunter P Wagner
The molecular changes that support implantation in eutherian mammals are necessary to establish pregnancy. In marsupials, pregnancy is relatively short, and although a placenta does form, it is present for only a few days before parturition. However, morphological changes in the uterus of marsupials at term mimic those that occur during implantation in humans and mice. We investigated the molecular similarity between term pregnancy in the marsupials and implantation in eutherian mammals using the gray short-tailed opossum (Monodelphis domestica) as a model...
July 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28738067/the-prediction-of-late-onset-preeclampsia-results-from-a-longitudinal-proteomics-study
#7
Offer Erez, Roberto Romero, Eli Maymon, Piya Chaemsaithong, Bogdan Done, Percy Pacora, Bogdan Panaitescu, Tinnakorn Chaiworapongsa, Sonia S Hassan, Adi L Tarca
BACKGROUND: Late-onset preeclampsia is the most prevalent phenotype of this syndrome; nevertheless, only a few biomarkers for its early diagnosis have been reported. We sought to correct this deficiency using a high through-put proteomic platform. METHODS: A case-control longitudinal study was conducted, including 90 patients with normal pregnancies and 76 patients with late-onset preeclampsia (diagnosed at ≥34 weeks of gestation). Maternal plasma samples were collected throughout gestation (normal pregnancy: 2-6 samples per patient, median of 2; late-onset preeclampsia: 2-6, median of 5)...
2017: PloS One
https://www.readbyqxmd.com/read/28728156/predicting-the-risk-to-develop-preeclampsia-in-the-first-trimester-combining-promoter-variant-98a-c-of-lgals13-placental-protein-13-black-ethnicity-previous-preeclampsia-obesity-and-maternal-age
#8
Liora Madar-Shapiro, Ido Karady, Alla Trahtenherts, Argryo Syngelaki, Ranjit Akolekar, Liona Poon, Ruth Cohen, Adi Sharabi-Nov, Berthold Huppertz, Marei Sammar, Kata Juhasz, Nandor Gabor Than, Zoltan Papp, Roberto Romero, Kypros H Nicolaides, Hamutal Meiri
BACKGROUND: LGALS13 (placental protein 13 [PP13]) promoter DNA polymorphisms was evaluated in predicting preeclampsia (PE), given PP13's effects on hypotension, angiogenesis, and immune tolerance. METHODS: First-trimester plasma samples (49 term and 18 intermediate) of PE cases matched with 196 controls were collected from King's College Hospital, London, repository. Cell-free DNA was extracted and the LGALS13 exons were sequenced after PCR amplification. Expression of LGALS13 promoter reporter constructs was determined in BeWo trophoblast-like cells with luciferase assays...
July 21, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28726590/a-method-of-managing-severe-traumatic-brain-injury-in-the-absence-of-intracranial-pressure-monitoring-the-ice-protocol
#9
Randall Chesnut, Nancy Temkin, Sureyya Dikmen, Carlos Rondina, Walter Videtta, Gustavo Petroni, Silvia Lujan, Victor Alanis, Antonio Luis Eiras Falcao, Gustavo La Fuente, Luis Gonzalez, Manuel Jibaja, Arturo Lavendez, Freddy Sandi Lora, Roberto Merida, Ricardo Romero, James Pridgeon, Jason Barber, Joan Machamer, Kelley Chaddock
Purpose - The imaging- and clinical-examination (ICE) algorithm used in the BEST TRIP ICP randomized controlled trial is the only prospectively investigated clinical protocol for TBI management without ICP monitoring. As the default literature standard, it warrants careful evaluation. Methods - We present the ICE protocol in detail and analyse the demographics, outcome, treatment intensity, frequency of intervention usage, and related adverse events in the ICE-protocol cohort. Results - The 167 ICE protocol patients were young (median 29 years) with a median Glasgow Coma Scale motor score of 4 but with anisocoria or abnormal pupillary reactivity in 40%...
July 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28718494/the-hiv-care-cascade-in-buenos-aires-argentina-results-in-a-tertiary-referral-hospital
#10
Carina Cesar, Gabriela Blugerman, José Antonio Valiente, Peter Rebeiro, Omar Sued, Valeria Fink, Mariana Romero Soto, Roberto Cillis, Cleyton Yamamoto, Carlos Falistocco, Pedro Cahn, Héctor Pérez
Objective: To determine rates of retention, antiretroviral therapy (ART) use, and viral suppression in an adult cohort from a public tertiary referral hospital in the city of Buenos Aires, Argentina. Methods: HIV-positive ART-naïve patients ≥ 18 years old starting care 2011-2013 contributed data until the end of 2014. Three outcomes were assessed in 2014: retention in care, ART use, and viral suppression. Patient characteristics associated with each outcome were assessed through logistic regression...
December 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28710912/giants-in-obstetrics-and-gynecology-series-a-profile-of-leon%C3%A2-speroff-%C3%A2-md
#11
EDITORIAL
Roberto Romero
No abstract text is available yet for this article.
July 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28707708/identification-and-quantification-of-phenolic-compounds-in-edible-wild-leafy-vegetables-by-uhplc-orbitrap-ms
#12
Elisa Giambanelli, L Filippo D'Antuono, Roberto Romero-González, Antonia Garrido Frenich
BACKGROUND: A recent interest in edible wild leafy vegetables has been documented. Consumers often associate these species to health promotion. In this study several wild species of the Asteraceae family and Knautia integrifolia (Dipsacaceae) were locally documented for their use in traditional cuisine and sampled from the wild. RESULTS: Phenolic compounds were identified and quantified by ultra-high-performance liquid chromatography coupled to Orbitrap high resolution mass spectrometry...
July 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28704641/giants-in-obstetrics-and-gynecology-series-a-profile-of-donald-r-coustan-md
#13
EDITORIAL
Roberto Romero
No abstract text is available yet for this article.
July 10, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28693123/clinical-chorioamnionitis-at-term-viii-a-rapid-mmp-8-test-for-the-identification-of-intra-amniotic-inflammation
#14
Noppadol Chaiyasit, Roberto Romero, Piya Chaemsaithong, Nikolina Docheva, Gaurav Bhatti, Juan Pedro Kusanovic, Zhong Dong, Lami Yeo, Percy Pacora, Sonia S Hassan, Offer Erez
OBJECTIVE: Clinical chorioamnionitis is the most common infection/inflammatory process diagnosed in labor and delivery units worldwide. The condition is a syndrome that can be caused by (1) intra-amniotic infection, (2) intra-amniotic inflammation without demonstrable microorganisms (i.e. sterile intra-amniotic inflammation), and (3) maternal systemic inflammation that is not associated with intra-amniotic inflammation. The presence of intra-amniotic inflammation is a risk factor for adverse maternal and neonatal outcomes in a broad range of obstetrical syndromes that includes clinical chorioamnionitis at term...
June 24, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28692891/degradation-studies-of-quizalofop-p-and-related-compounds-in-soils-using-liquid-chromatography-coupled-to-low-and-high-resolution-mass-analyzers
#15
Rosalía López-Ruiz, Roberto Romero-González, José Luis Martínez Vidal, Manuel Fernández-Pérez, Antonia Garrido Frenich
A comprehensive degradation study of quizalofop-p, quizalofop-p-ethyl, quizalofop-p-tefuryl and propaquizafop in soil samples have been firstly performed using ultra high performance liquid chromatography coupled to Orbitrap mass spectrometry (UHPLC-Orbitrap-MS). Thus, metabolites or degradation products, such as CHHQ (dihydroxychloroquinoxalin), CHQ (6-chloroquinoxalin-2-ol), PPA ((R)-2-(4-hydroxyphenoxy)propionic acid) and 2,3-dihydroxyquinoxaline were also monitored. An extraction procedure based on QuEChERS procedure was used...
July 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28692822/giants-in-obstetrics-and-gynecology-series-a-profile-of-alan-h-decherney-md
#16
EDITORIAL
Roberto Romero
No abstract text is available yet for this article.
July 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28676199/the-art-score-is-not-an-effective-tool-for-optimizing-patient-selection-for-deb-tace-retreatment-a-multicentre-spanish-study
#17
Maria Pipa-Muñiz, Lluis Castells, Sonia Pascual, Javier Fernández-Castroagudín, Iratxe Díez-Miranda, Javier Irurzun, Roberto Díaz-Beveridge, María Senosiaín, Juan Arenas, Manuel de la Mata, Juan Turnes, María Isabel Monge-Romero, Daniel Pérez-Enguix, Javier Bustamante-Schneider, Nora Otegui, Esther Molina-Pérez, José Eduardo Rodríguez-Menéndez, Maria Varela
INTRODUCTION: The appropriate selection of hepatocellular carcinoma (HCC) patients who are eligible for transarterial chemoembolization (TACE) remains a challenge. The ART score has recently been proposed as a method of identifying patients who are eligible or not for a second TACE procedure. OBJECTIVE: To assess the validity of the Assessment for Retreatment with TACE (ART) score in a cohort of patients treated with drug-eluting bead TACE (DEB-TACE). SECONDARY OBJECTIVE: to identify clinical determinants associated with overall survival (OS)...
July 1, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28672753/the-combined-exposure-to-intra-amniotic-inflammation-and-neonatal-respiratory-distress-syndrome-increases-the-risk-of-intraventricular-hemorrhage-in-preterm-neonates
#18
Kyung Joon Oh, Jee Yoon Park, JoonHo Lee, Joon-Seok Hong, Roberto Romero, Bo Hyun Yoon
OBJECTIVE: To evaluate the impact of combined exposure to intra-amniotic inflammation and neonatal respiratory distress syndrome (RDS) on the development of intraventricular hemorrhage (IVH) in preterm neonates. METHODS: This retrospective cohort study includes 207 consecutive preterm births (24.0-33.0 weeks of gestation). Intra-amniotic inflammation was defined as an amniotic fluid matrix metalloproteinase-8 concentration >23 ng/mL. According to McMenamin's classification, IVH was defined as grade II or higher when detected by neurosonography within the first weeks of life...
June 26, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28672752/clinical-chorioamnionitis-at-term-viii-a-rapid-mmp-8-test-for-the-identification-of-intra-amniotic-inflammation
#19
Noppadol Chaiyasit, Roberto Romero, Piya Chaemsaithong, Nikolina Docheva, Gaurav Bhatti, Juan Pedro Kusanovic, Zhong Dong, Lami Yeo, Percy Pacora, Sonia S Hassan, Offer Erez
OBJECTIVE: Clinical chorioamnionitis is the most common infection/inflammatory process diagnosed in labor and delivery units worldwide. The condition is a syndrome that can be caused by (1) intra-amniotic infection, (2) intra-amniotic inflammation without demonstrable microorganisms (i.e. sterile intra-amniotic inflammation), and (3) maternal systemic inflammation that is not associated with intra-amniotic inflammation. The presence of intra-amniotic inflammation is a risk factor for adverse maternal and neonatal outcomes in a broad range of obstetrical syndromes that includes clinical chorioamnionitis at term...
July 26, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28671275/curtailed-t-cell-activation-curbs-effector-differentiation-and-generates-cd8-t-cells-with-a-naturally-occuring-memory-stem-cell-phenotype
#20
Veronica Zanon, Karolina Pilipow, Eloise Scamardella, Federica De Paoli, Gabriele De Simone, David A Price, Amaia Martinez Usatorre, Pedro Romero, Domenico Mavilio, Alessandra Roberto, Enrico Lugli
Human T memory stem (TSCM ) cells with superior persistence capacity and effector functions are emerging as important players in the maintenance of long-lived T-cell memory and are thus considered an attractive population to be used in adoptive transfer-based immunotherapy of cancer. However, the molecular signals regulating their generation remain poorly defined. Here we show that curtailed T-cell receptor stimulation curbs human effector CD8(+) T-cell differentiation and allows the generation of CD45RO(-) CD45RA(+) CCR7(+) CD27(+) CD95(+) -phenotype cells from highly purified naïve T-cell precursors, resembling naturally-occurring human TSCM ...
July 3, 2017: European Journal of Immunology
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