Jian-Hua Zhang, Yi-Fei Zhao, Xiao-Xiao He, Yang Zhao, Zi-Xuan He, Lei Zhang, Ying Huang, Yu-Bing Wang, Ling Hu, Lin Liu, Hua-Li Yu, Jia-Hui Xu, Ming-Ming Lai, Dong-Dong Zhao, Lei Cui, Wei-Xiang Guo, Wen-Cheng Xiong, Yu-Qiang Ding, Xiao-Juan Zhu
Newborn neurons undergo inside-out migration to their final destinations during neocortical development. Reelin-induced tyrosine phosphorylation of disabled 1 (Dab1) is a critical mechanism controlling cortical neuron migration. However, the roles of Reelin-independent phosphorylation of Dab1 remain unclear. Here, we report that deleted in colorectal carcinoma (DCC) interacts with Dab1 via its P3 domain. Netrin 1, a DCC ligand, induces Dab1 phosphorylation at Y220 and Y232. Interestingly, knockdown of DCC or truncation of its P3 domain dramatically delays neuronal migration and impairs the multipolar-to-bipolar transition of migrating neurons...
March 27, 2018: Cell Reports