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Y-J Li, H-X Zhu, D Zhang, H-C Li, P Ma, L-Y Huang
Platelets are megakaryocyte-derived nuclear-free fragments that participate in cardiovascular diseases including acute myocardial infarction, ischemic stroke, hypertension, and atherosclerosis. At the endothelium damage site, platelets interact with sub-endothelial matrix proteins such as glycoprotein VI/Fc receptor γ-chain (GPVI/FcRγ), G protein-coupled receptor/phospholipase Cγ(β) (GPCR/PLCγ(β)), Rho/RhoK and integrin. The activation of these signaling pathways triggers intracellular calcium increase and causes platelet adhesion, aggregation, granule release and finally thrombus formation...
July 2017: European Review for Medical and Pharmacological Sciences
Dinesh M Tripathi, Eva Erice, Erica Lafoz, Héctor García-Calderó, Shiv K Sarin, Jaime Bosch, Jordi Gracia-Sancho, Juan Carlos García-Pagán
Increased hepatic vascular resistance is the primary factor in the development of portal hypertension. Metformin ameliorates vascular cells function in several vascular beds. Our study was aimed at evaluating the effects, and the underlying mechanisms, of metformin on hepatic and systemic hemodynamics in cirrhotic rats and its possible interaction with the effects of propranolol (Prop), the current standard treatment for portal hypertension. CCl4-cirrhotic rats received by gavage metformin 300 mg/kg or its vehicle once a day for 1 wk, before mean arterial pressure (MAP), portal pressure (PP), portal blood flow (PBF), hepatic vascular resistance, and putative molecular/cellular mechanisms were measured...
September 1, 2015: American Journal of Physiology. Gastrointestinal and Liver Physiology
Pranee Liamputtong, Dusanee Suwankhong
In this article we draw on Bury's theory of biographical disruption to discuss the meanings of, and emotional experiences related to, being diagnosed with breast cancer among southern Thai women. Qualitative methods, including in-depth interviewing and drawing methods, were used to collect data from 20 women with breast cancer. The women perceived breast cancer to be a rhok raai; an evil or dread disease. They believed that breast cancer would lead to death. The disruption in their biography occurred when they detected abnormalities indicating breast cancer...
September 2015: Sociology of Health & Illness
Dimitrios Konstantonis, Adamantia Papadopoulou, Margarita Makou, Theodore Eliades, Efthimia Basdra, Dimitris Kletsas
Mechanical loading is considered to be a major parameter of the periodontal ligament (PDL) remodeling and differentiation. However, the molecular mechanisms that translate these forces to cellular responses are not fully elucidated. Especially, although aging affects PDL homeostasis, the role of cellular senescence on the activation of signaling pathways in periodontal ligament fibroblasts (PDLF) in response to mechanical stimulation has not been studied yet. Here, we present evidence showing that cyclic mechanical stimulation activates ERK, JNK and p38 MAPK in young (early-passage) human PDLF, in a RhoK-dependent manner...
September 2014: Experimental Gerontology
Matthew Thomas, Loredana Ciuclan, Martin J Hussey, Neil J Press
As we uncover the complex pathophysiology underlying idiopathic and familial pulmonary arterial hypertension, multiple disease associated pathways, cell types and processes reveal links to elements of the serotonin system. Beyond the original 'serotonin hypothesis' observed with anorexigens, and the latterly demonstrated association with vascular tone and pulmonary artery smooth muscle cell proliferation, recent studies suggest links to BMPR2, PDGF and RhoK pathways, as well as an impact upon more complex lesion formation and pathologic bone marrow progenitor mobilization...
June 2013: Pharmacology & Therapeutics
Jean-Pierre Savineau, Roger Marthan, Eric Dumas de la Roque
Dehydroepiandrosterone (DHEA) is a steroid hormone derived from cholesterol synthesized by the adrenal glands. DHEA and its 3β-sulphate ester (DHEA-S) are the most abundant circulating steroid hormones. In human, there is a clear age-related decline in serum DHEA and DHEA-S and this has suggested that a relative deficiency in these steroids may be causally related to the development of a series of diseases associated with aging including cardiovascular diseases (CVD). This commentary aims to highlight the action of DHEA in CVD and its beneficial effect in therapy...
March 15, 2013: Biochemical Pharmacology
Mar Coll, Sarai Rodriguez, Imma Raurell, Nahia Ezkurdia, Astrid Brull, Salvador Augustin, Jaime Guardia, Rafael Esteban, María Martell, Joan Genescà
UNLABELLED: We aimed to evaluate the effects of droxidopa (an oral synthetic precursor of norepinephrine) on the hemodynamic and renal alterations of portal hypertensive rats. Sham, portal vein-ligated (PVL), and 4-week biliary duct-ligated (BDL) rats received a single oral dose of droxidopa (25-50 mg/kg) or vehicle and hemodynamic parameters were monitored for 2 hours. Two groups of BDL and cirrhotic rats induced by carbon tetrachloride (CCl(4) ) were treated for 5 days with droxidopa (15 mg/kg, twice daily, orally); hemodynamic parameters and blood and urinary parameters were assessed...
November 2012: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
A A Kramerov, K Ahmed, A V Ljubimov
Protein kinase CK2 participates in a wide range of cellular events, including the regulation of cellular morphology and migration, and may be an important mediator of angiogenesis. We previously showed that in the retina, CK2 immunolocalizes mostly to vascular endothelium and astrocytes in association with the cytoskeleton. Additionally, CK2 inhibitors significantly reduced retinal neovascularization and stem cell recruitment in the mouse model of oxygen-induced proliferative retinopathy. We have also shown that CK2 and F-actin co-localized in actin stress fibers in microvascular endothelial cells, and that highly specific CK2 inhibitors caused cell rounding in astrocytes and microvascular endothelial cells, which was alleviated by serum that promotes spreading by Rho/Rho-kinase (RhoK) activation of myosin II...
September 2012: Journal of Cellular Biochemistry
Nuria Villalba, Cristina Contreras, Medardo Hernández, Albino García-Sacristán, Dolores Prieto
Diabetes is associated with an increased vascular tone usually involved in the pathogenesis of diabetic cardiovascular complications such as hypertension, stroke, coronary artery disease, or erectile dysfunction (ED). Enhanced contractility of penile erectile tissue has been associated with augmented activity of the RhoA/Rho kinase (RhoK) pathway in models of diabetes-associated ED. The present study assessed whether abnormal vasoconstriction in penile arteries from prediabetic obese Zucker rats (OZRs) is due to changes in the intracellular Ca(2+) concentration ([Ca(2+)](i)) and/or in myofilament Ca(2+) sensitivity...
June 2011: American Journal of Physiology. Heart and Circulatory Physiology
Prisca Mbikou, Ales Fajmut, Milan Brumen, Etienne Roux
We investigated theoretically and experimentally the role of Rho kinase (RhoK) in Ca(2+)-contraction coupling in rat airways. Isometric contraction was measured on tracheal, extrapulmonary and intrapulmonary bronchial rings. Intracellular [Ca(2+)] was recorded in freshly isolated tracheal myocytes. Stimulation by carbachol (0.3 and 10 μm) and 50 mm external KCl induced a short-time, Hill-shaped contraction obtained within 90 s, followed by a sustained or an additional delayed contraction. Responses of [Ca(2+)](i) to acetylcholine consisted in a fast peak followed by a plateau and, in 42% of the cells, superimposed Ca(2+) oscillations...
February 2011: Experimental Physiology
Bertrand Bénazéraf, Paul Francois, Ruth E Baker, Nicolas Denans, Charles D Little, Olivier Pourquié
Vertebrate embryos are characterized by an elongated antero-posterior (AP) body axis, which forms by progressive cell deposition from a posterior growth zone in the embryo. Here, we used tissue ablation in the chicken embryo to demonstrate that the caudal presomitic mesoderm (PSM) has a key role in axis elongation. Using time-lapse microscopy, we analysed the movements of fluorescently labelled cells in the PSM during embryo elongation, which revealed a clear posterior-to-anterior gradient of cell motility and directionality in the PSM...
July 8, 2010: Nature
Ynuk Bossé, Dennis Solomon, Leslie Y M Chin, Kevin Lian, Peter D Paré, Chun Y Seow
The amplitude of strain in airway smooth muscle (ASM) produced by oscillatory perturbations such as tidal breathing or deep inspiration (DI) influences the force loss in the muscle and is therefore a key determinant of the bronchoprotective and bronchodilatory effects of these breathing maneuvers. The stiffness of unstimulated ASM (passive stiffness) directly influences the amplitude of strain. The nature of the passive stiffness is, however, not clear. In this study, we measured the passive stiffness of ovine ASM at different muscle lengths (relative to in situ length, which was used as a reference length, L(ref)) and states of adaptation to gain insights into the origin of this muscle property...
March 2010: American Journal of Physiology. Lung Cellular and Molecular Physiology
Jayalakshmi Krishnan, Jiayan Chen, Kum Joo Shin, Jong Ik Hwang, Sang Uk Han, Gwang Lee, Sangdun Choi
Exposure to light can induce photoreceptor cell death and exacerbate retinal degeneration. In this study, mice with genetic knockout of several genes, including rhodopsin kinase (Rhok-/-), arrestin (Sag-/-), transducin (Gnat1-/-), c-Fos (c-Fos-/-) and arrestin/transducin (Sag-/-/Gnat1-/-), were examined. We measured the expression levels of thousands of genes in order to investigate their roles in phototransduction signaling in light-induced retinal degeneration using DNA microarray technology and then further explored the gene network using pathway analysis tools...
October 31, 2008: Experimental & Molecular Medicine
F Kent Fulcher, Bethany T Smith, Misty Russ, Yashomati M Patel
Insulin-stimulated glucose uptake requires the activation of several signaling pathways to mediate the translocation and fusion of GLUT4 vesicles to the plasma membrane. Our previous studies demonstrated that GLUT4-mediated glucose uptake is a myosin II-dependent process in adipocytes. The experiments described in this report are the first to show a dual role for the myosin IIA isoform specifically in regulating insulin-stimulated glucose uptake in adipocytes. We demonstrate that inhibition of MLCK but not RhoK results in impaired insulin-stimulated glucose uptake...
October 15, 2008: Experimental Cell Research
Jayalakshmi Krishnan, Gwang Lee, Sang-Uk Han, Sangdun Choi
Understanding the molecular pathways mediating neuronal function in retinas can be greatly facilitated by the identification of genes regulated in the retinas of different mutants under various light conditions. We attempted to conduct a gene chip analysis study on the genes regulated during rhodopsin kinase (Rhok-/-) and arrestin (Sag-/-) knockout and double knockouts in mice retina. Hence, mice were exposed to constant illumination of 450 lux or 6,000 lux on dilated pupils for indicated periods. The retinas were removed after the exposure and processed for microarray analysis...
2008: Journal of Biomedicine & Biotechnology
Masaru Yamamoto, Servio H Ramirez, Shinji Sato, Tomomi Kiyota, Ronald L Cerny, Kozo Kaibuchi, Yuri Persidsky, Tsuneya Ikezu
Critical to the proper maintenance of blood-brain-barrier (BBB) integrity are the endothelial tight junctions (TJs). Posttranslational modifications of essential endothelial TJ proteins, occludin and claudin-5, contribute and possibly disrupt BBB integrity. Our previous work has shown that Rho kinase (RhoK) activation mediates occludin and claudin-5 phosphorylation resulting in diminished barrier tightness and enhanced monocyte migration across BBB in the setting of human immunodeficiency virus-1 encephalitis (HIVE)...
February 2008: American Journal of Pathology
Ellen L Batchelder, Christina L Thomas-Virnig, Jeffery D Hardin, John G White
Furrow ingression in animal cell cytokinesis is controlled by phosphorylation of myosin II regulatory light chain (mRLC). In Caenorhabditis elegans embryos, Rho-dependent Kinase (RhoK) is involved in, but not absolutely required for, this phosphorylation. The calmodulin effector myosin light chain kinase (MLCK) can also phosphorylate mRLC and is widely regarded as a candidate for redundant function with RhoK. However, our results show that RNA mediated interference against C. elegans calmodulin and candidate MLCKs had no effect on cytokinesis in wild-type or RhoK mutant embryos, ruling out the calmodulin/MLCK pathway as the missing regulator of cytokinesis in the C...
September 4, 2007: FEBS Letters
D Prieto
Recent experimental evidence suggests that arterial insufficiency precedes the structural and functional changes in corpora cavernosa (CC) leading to organic erectile dysfunction (ED). The present review gives an overview of the physiological factors involved in the regulation of penile vasculature. Sympathetic nerves maintain flaccidity and tonically released noradrenaline induces vasoconstriction of both arteries and veins through alpha(1)- and alpha(2)-postsynaptic receptors and downregulates its own release and that of nitric oxide (NO) through alpha(2)-presynaptic receptors...
January 2008: International Journal of Impotence Research
Wei-Shu Hou, Hsiang-nan Li, Satoshi Mishima, Makiko Nagashima
We study the effect from a sequential fourth generation quark on penguin-dominated two-body nonleptonic B meson decays in the next-to-leading order perturbative QCD formalism. With an enhancement of the color-suppressed tree amplitude and possibility of a new CP phase in the electroweak penguin amplitude, we can account better for A(CP)(B(0)-->K+ pi-)-A(CP)(B+-->K+ pi0). Taking |V(t's)V(t'b)| approximately 0.02 with a phase just below 90 degrees, which is consistent with the b-->sl+ l- rate and the B(s) mixing parameter Deltam(B)(s), we find a downward shift in the mixing-induced CP asymmetries of B(0)-->K(S)(pi 0) and phi(K)(S)...
March 30, 2007: Physical Review Letters
B Aubert, R Barate, M Bona, D Boutigny, F Couderc, Y Karyotakis, J P Lees, V Poireau, V Tisserand, A Zghiche, E Grauges, A Palano, J C Chen, N D Qi, G Rong, P Wang, Y S Zhu, G Eigen, I Ofte, B Stugu, G S Abrams, M Battaglia, D N Brown, J Button-Shafer, R N Cahn, E Charles, M S Gill, Y Groysman, R G Jacobsen, J A Kadyk, L T Kerth, Yu G Kolomensky, G Kukartsev, G Lynch, L M Mir, T J Orimoto, M Pripstein, N A Roe, M T Ronan, W A Wenzel, P del Amo Sanchez, M Barrett, K E Ford, T J Harrison, A J Hart, C M Hawkes, S E Morgan, A T Watson, T Held, H Koch, B Lewandowski, M Pelizaeus, K Peters, T Schroeder, M Steinke, J T Boyd, J P Burke, W N Cottingham, D Walker, T Cuhadar-Donszelmann, B G Fulsom, C Hearty, N S Knecht, T S Mattison, J A McKenna, A Khan, P Kyberd, M Saleem, D J Sherwood, L Teodorescu, V E Blinov, A D Bukin, V P Druzhinin, V B Golubev, A P Onuchin, S I Serednyakov, Yu I Skovpen, E P Solodov, K Yu Todyshev, D S Best, M Bondioli, M Bruinsma, M Chao, S Curry, I Eschrich, D Kirkby, A J Lankford, P Lund, M Mandelkern, R K Mommsen, W Roethel, D P Stoker, S Abachi, C Buchanan, S D Foulkes, J W Gary, O Long, B C Shen, K Wang, L Zhang, H K Hadavand, E J Hill, H P Paar, S Rahatlou, V Sharma, J W Berryhill, C Campagnari, A Cunha, B Dahmes, T M Hong, D Kovalskyi, J D Richman, T W Beck, A M Eisner, C J Flacco, C A Heusch, J Kroseberg, W S Lockman, G Nesom, T Schalk, B A Schumm, A Seiden, P Spradlin, D C Williams, M G Wilson, J Albert, E Chen, A Dvoretskii, F Fang, D G Hitlin, I Narsky, T Piatenko, F C Porter, A Ryd, A Samuel, G Mancinelli, B T Meadows, K Mishra, M D Sokoloff, F Blanc, P C Bloom, S Chen, W T Ford, J F Hirschauer, A Kreisel, M Nagel, U Nauenberg, A Olivas, W O Ruddick, J G Smith, K A Ulmer, S R Wagner, J Zhang, A Chen, E A Eckhart, A Soffer, W H Toki, R J Wilson, F Winklmeier, Q Zeng, D D Altenburg, E Feltresi, A Hauke, H Jasper, A Petzold, B Spaan, T Brandt, V Klose, H M Lacker, W F Mader, R Nogowski, J Schubert, K R Schubert, R Schwierz, J E Sundermann, A Volk, D Bernard, G R Bonneaud, P Grenier, E Latour, Ch Thiebaux, M Verderi, P J Clark, W Gradl, F Muheim, S Playfer, A I Robertson, Y Xie, M Andreotti, D Bettoni, C Bozzi, R Calabrese, G Cibinetto, E Luppi, M Negrini, A Petrella, L Piemontese, E Prencipe, F Anulli, R Baldini-Ferroli, A Calcaterra, R de Sangro, G Finocchiaro, S Pacetti, P Patteri, I M Peruzzi, M Piccolo, M Rama, A Zallo, A Buzzo, R Capra, R Contri, M Lo Vetere, M M Macri, M R Monge, S Passaggio, C Patrignani, E Robutti, A Santroni, S Tosi, G Brandenburg, K S Chaisanguanthum, M Morii, J Wu, R S Dubitzky, J Marks, S Schenk, U Uwer, D J Bard, W Bhimji, D A Bowerman, P D Dauncey, U Egede, R L Flack, J A Nash, M B Nikolich, W Panduro Vazquez, P K Behera, X Chai, M J Charles, U Mallik, N T Meyer, V Ziegler, J Cochran, H B Crawley, L Dong, V Eyges, W T Meyer, S Prell, E I Rosenberg, A E Rubin, A V Gritsan, A G Denig, M Fritsch, G Schott, N Arnaud, M Davier, G Grosdidier, A Höcker, F Le Diberder, V Lepeltier, A M Lutz, A Oyanguren, S Pruvot, S Rodier, P Roudeau, M H Schune, A Stocchi, W F Wang, G Wormser, C H Cheng, D J Lange, D M Wright, C A Chavez, I J Forster, J R Fry, E Gabathuler, R Gamet, K A George, D E Hutchcroft, D J Payne, K C Schofield, C Touramanis, A J Bevan, F Di Lodovico, W Menges, R Sacco, G Cowan, H U Flaecher, D A Hopkins, P S Jackson, T R McMahon, S Ricciardi, F Salvatore, A C Wren, D N Brown, C L Davis, J Allison, N R Barlow, R J Barlow, Y M Chia, C L Edgar, G D Lafferty, M T Naisbit, J C Williams, J I Yi, C Chen, W D Hulsbergen, A Jawahery, C K Lae, D A Roberts, G Simi, G Blaylock, C Dallapiccola, S S Hertzbach, X Li, T B Moore, S Saremi, H Staengle, R Cowan, G Sciolla, S J Sekula, M Spitznagel, F Taylor, R K Yamamoto, H Kim, S E McLachlin, P M Patel, S H Robertson, A Lazzaro, V Lombardo, F Palombo, J M Bauer, L Cremaldi, V Eschenburg, R Godang, R Kroeger, D A Sanders, D J Summers, H W Zhao, S Brunet, D Côté, M Simard, P Taras, F B Viaud, H Nicholson, N Cavallo, G De Nardo, F Fabozzi, C Gatto, L Lista, D Monorchio, P Paolucci, D Piccolo, C Sciacca, M Baak, G Raven, H L Snoek, C P Jessop, J M LoSecco, T Allmendinger, G Benelli, K K Gan, K Honscheid, D Hufnagel, P D Jackson, H Kagan, R Kass, A M Rahimi, R Ter-Antonyan, Q K Wong, N L Blount, J Brau, R Frey, O Igonkina, M Lu, R Rahmat, N B Sinev, D Strom, J Strube, E Torrence, A Gaz, M Margoni, M Morandin, A Pompili, M Posocco, M Rotondo, F Simonetto, R Stroili, C Voci, M Benayoun, J Chauveau, H Briand, P David, L Del Buono, Ch de la Vaissière, O Hamon, B L Hartfiel, M J J John, Ph Leruste, J Malclès, J Ocariz, L Roos, G Therin, L Gladney, J Panetta, M Biasini, R Covarelli, C Angelini, G Batignani, S Bettarini, F Bucci, G Calderini, M Carpinelli, R Cenci, F Forti, M A Giorgi, A Lusiani, G Marchiori, M A Mazur, M Morganti, N Neri, E Paoloni, G Rizzo, J J Walsh, M Haire, D Judd, D E Wagoner, J Biesiada, N Danielson, P Elmer, Y P Lau, C Lu, J Olsen, A J S Smith, A V Telnov, F Bellini, G Cavoto, A D'Orazio, D del Re, E Di Marco, R Faccini, F Ferrarotto, F Ferroni, M Gaspero, L Li Gioi, M A Mazzoni, S Morganti, G Piredda, F Polci, F Safai Tehrani, C Voena, M Ebert, H Schröder, R Waldi, T Adye, N De Groot, B Franek, E O Olaiya, F F Wilson, R Aleksan, S Emery, M Escalier, A Gaidot, S F Ganzhur, G Hamel de Monchenault, W Kozanecki, M Legendre, G Vasseur, Ch Yèche, M Zito, X R Chen, H Liu, W Park, M V Purohit, J R Wilson, M T Allen, D Aston, R Bartoldus, P Bechtle, N Berger, R Claus, J P Coleman, M R Convery, M Cristinziani, J C Dingfelder, J Dorfan, G P Dubois-Felsmann, D Dujmic, W Dunwoodie, R C Field, T Glanzman, S J Gowdy, M T Graham, V Halyo, C Hast, T Hryn'ova, W R Innes, M H Kelsey, P Kim, D W G S Leith, S Li, S Luitz, V Luth, H L Lynch, D B MacFarlane, H Marsiske, R Messner, D R Muller, C P O'Grady, V E Ozcan, A Perazzo, M Perl, T Pulliam, B N Ratcliff, A Roodman, A A Salnikov, R H Schindler, J Schwiening, A Snyder, J Stelzer, D Su, M K Sullivan, K Suzuki, S K Swain, J M Thompson, J Va'vra, N van Bakel, M Weaver, A J R Weinstein, W J Wisniewski, M Wittgen, D H Wright, A K Yarritu, K Yi, C C Young, P R Burchat, A J Edwards, S A Majewski, B A Petersen, C Roat, L Wilden, S Ahmed, M S Alam, R Bula, J A Ernst, V Jain, B Pan, M A Saeed, F R Wappler, S B Zain, W Bugg, M Krishnamurthy, S M Spanier, R Eckmann, J L Ritchie, A Satpathy, C J Schilling, R F Schwitters, J M Izen, X C Lou, S Ye, F Bianchi, F Gallo, D Gamba, M Bomben, L Bosisio, C Cartaro, F Cossutti, G Della Ricca, S Dittongo, L Lanceri, L Vitale, V Azzolini, F Martinez-Vidal, Sw Banerjee, B Bhuyan, C M Brown, D Fortin, K Hamano, R Kowalewski, I M Nugent, J M Roney, R J Sobie, J J Back, P F Harrison, T E Latham, G B Mohanty, M Pappagallo, H R Band, X Chen, B Cheng, S Dasu, M Datta, K T Flood, J J Hollar, P E Kutter, H Li, B Mellado, A Mihalyi, Y Pan, M Pierini, R Prepost, S L Wu, Z Yu, H Neal et al.
We report searches for B-meson decays to the charmless final states rhoK* and f0(980)K* with a sample of 232x10(6) BB pairs collected with the BABAR detector at the PEP-II e+e- collider. We measure in units of 10(-6) the following branching fractions, where the first error quoted is statistical and the second systematic, or upper limits are given at the 90% confidence level: B(B+-->rho0K*+)<6.1, B(B+-->rho+K*0)=9.6+/-1.7+/-1.5, B(B0-->rho-K*+)<12.0, B(B0-->rho0K*0)=5.6+/-0.9+/-1.3, B(B+-->f0(980)K*+)=5...
November 17, 2006: Physical Review Letters
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