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David dodick

Richard S Koplin, David C Ritterband, Jack M Dodick, Eric D Donnenfeld, Mark Schafer
PURPOSE: To determine the relationship between untoward events noted during phacoemulsification surgery associated with aberrant infusion misdirection and their causal relationship to current infusion sleeve design. SETTING: The New York Eye & Ear Infirmary of Mt. Sinai, New York, New York, USA. DESIGN: Retrospective case reports and experimental study. METHODS: Observations of live cataract surgery were documented with high-definition videography using 3 commercial phacoemulsification platforms...
August 2016: Journal of Cataract and Refractive Surgery
Michael Von Korff, Ann I Scher, Charles Helmick, Olivia Carter-Pokras, David W Dodick, Joseph Goulet, Robin Hamill-Ruth, Linda LeResche, Linda Porter, Raymond Tait, Gregory Terman, Christin Veasley, Sean Mackey
UNLABELLED: National Pain Strategy population research objectives include: estimating chronic pain prevalence, studying pain treatment with electronic health care data, and developing metrics to assess progress in reducing chronic pain impact. In this article, the National Pain Strategy Population Research Workgroup reviews concepts relevant to achieving these aims. High-impact chronic pain was defined as persistent pain with substantial restriction of life activities lasting 6 months or more...
October 2016: Journal of Pain: Official Journal of the American Pain Society
Marcelo E Bigal, David W Dodick, Abouch V Krymchantowski, Juliana H VanderPluym, Stewart J Tepper, Ernesto Aycardi, Pippa S Loupe, Yuju Ma, Peter J Goadsby
OBJECTIVE: To evaluate the onset of efficacy of TEV-48125, a monoclonal antibody against calcitonin gene-related peptide, recently shown to be effective for the preventive treatment of chronic migraine (CM) and high-frequency episodic migraine. METHODS: A randomized placebo-controlled study tested once-monthly injections of TEV-48125 675/225 mg or 900 mg vs placebo. Headache information was captured daily using an electronic headache diary. The primary endpoint was change from baseline in the number of headache hours in month 3...
July 5, 2016: Neurology
Tiffini Voss, Richard B Lipton, David W Dodick, Nicole Dupre, Joy Yang Ge, Robert Bachman, Christopher Assaid, Sheena K Aurora, David Michelson
AIM: The aim of this trial was to evaluate the efficacy and tolerability of ubrogepant (MK-1602), a calcitonin gene-related peptide receptor antagonist (CGRP-RA), for the acute treatment of migraine. METHODS: This double-blind, placebo-controlled study randomized 834 participants to treat one migraine attack with ubrogepant 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, or placebo in a 1:1 ratio. The co-primary endpoints were pain freedom and headache response at two hours...
August 2016: Cephalalgia: An International Journal of Headache
Caroline Machado Kopruszinski, Jennifer Yanhua Xie, Nathan Mackenzie Eyde, Bethany Remeniuk, Sarah Walter, Jennifer Stratton, Marcelo Bigal, Juliana Geremias Chichorro, David Dodick, Frank Porreca
OBJECTIVE: The objective of this study was the determination of the role of calcitonin gene-related peptide (CGRP) in the induction of medication overuse headache (MOH)-related migraine in an injury-free preclinical model. METHODS: Rats were primed by a 7-day period of exposure to acute migraine therapies including sumatriptan and morphine. After an additional 14-day drug-free period, rats were exposed to putative migraine triggers including bright light stress (BLS) or nitric oxide (NO) donor in the presence or absence of TEV48125, a fully humanized CGRP antibody...
May 19, 2016: Cephalalgia: An International Journal of Headache
Catherine D Chong, Todd J Schwedt, David W Dodick
Although migraine symptomatology is well-defined, our understanding of migraine pathophysiology is incomplete. Structural and functional brain imaging can contribute to a greater understanding of migraine pathophysiology. Recent neuroimaging studies demonstrate that migraine is associated with structural and functional alterations of brain regions commonly implicated in pain processing. This review summarizes recent brain structural and functional imaging findings in migraine and highlights those that are associated with characteristics such as the presence or absence of aura, associated cognitive dysfunction, sex-differences (male vs...
July 2016: Current Neurology and Neuroscience Reports
Daniel Fossum Bratbak, Ståle Nordgård, Lars Jacob Stovner, Mattias Linde, David W Dodick, Irina Aschehoug, Mari Folvik, Erling Tronvik
OBJECTIVE: The main objective of this pilot study was to investigate the safety of administering onabotulinumtoxinA towards the sphenopalatine ganglion in 10 patients with intractable chronic migraine with an open, uncontrolled design. We also collected efficacy data to provide an indication as to whether future placebo-controlled studies should be performed. METHOD: In a prospective, open-label, uncontrolled study after one-month baseline, we performed bilateral injections of 25 IU onabotulinumtoxinA (total dose 50 IU) toward the sphenopalatine ganglion in a single outpatient session in 10 patients with intractable migraine with a follow-up of 12 weeks...
May 6, 2016: Cephalalgia: An International Journal of Headache
David W Dodick, Elizabeth W Loder, Aubrey Manack Adams, Dawn C Buse, Kristina M Fanning, Michael L Reed, Richard B Lipton
OBJECTIVE: To assess the rates and predictors of traversing steps essential to good medical care for chronic migraine, including: (1) medical consultation, (2) accurate diagnosis, and (3) minimal pharmacologic treatment. Candidate predictors included socioeconomic, demographic, and headache-specific variables. BACKGROUND: Previous research has established that barriers to effective management for episodic migraine include the absence of health insurance, lack of appropriate medical consultation, failure to receive an accurate diagnosis, and not being offered a regimen with acute and preventive treatments...
May 3, 2016: Headache
Dawn C Buse, Ann I Scher, David W Dodick, Michael L Reed, Kristina M Fanning, Aubrey Manack Adams, Richard B Lipton
OBJECTIVE: To assess the impact of migraine on family members, activities, and relationships from the perspectives of the person with migraine and his or her spouse/domestic partner. PATIENTS AND METHODS: The Chronic Migraine Epidemiology and Outcomes (CaMEO) study is a longitudinal, Web-based study conducted from September 2012 to November 2013. Quota sampling from an online panel identified respondents who met modified International Classification of Headache Disorders, version 3 beta migraine criteria...
April 25, 2016: Mayo Clinic Proceedings
Hong Sun, David W Dodick, Stephen Silberstein, Peter J Goadsby, Uwe Reuter, Messoud Ashina, Joel Saper, Roger Cady, Yun Chon, Julie Dietrich, Robert Lenz
BACKGROUND: The calcitonin gene-related peptide (CGRP) pathway is a promising target for preventive therapies in patients with migraine. We assessed the safety and efficacy of AMG 334, a fully human monoclonal antibody against the CGRP receptor, for migraine prevention. METHODS: In this multicentre, randomised, double-blind, placebo-controlled, phase 2 trial, patients aged 18-60 years with 4 to 14 migraine days per month were enrolled at 59 headache and clinical research centres in North America and Europe, and randomly assigned in a 3:2:2:2 ratio to monthly subcutaneous placebo, AMG 334 7 mg, AMG 334 21 mg, or AMG 334 70 mg using a sponsor-generated randomisation sequence centrally executed by an interactive voice response or interactive web response system...
April 2016: Lancet Neurology
Hans-Christoph Diener, David W Dodick
No abstract text is available yet for this article.
January 2016: Lancet Neurology
Zsolt Hepp, Noah L Rosen, Patrick G Gillard, Sepideh F Varon, Nitya Mathew, David W Dodick
BACKGROUND: Migraine, especially chronic migraine (CM), causes substantial disability; however, health care utilization has not been well characterized among patients receiving different migraine prophylactic treatments. METHODS: Using a large, US-based, health care claims database, headache-related health care utilization was evaluated among adults with CM treated with onabotulinumtoxinA or oral migraine prophylactic medications (OMPMs). Headache-related health care utilization was assessed at six, nine, and 12 months pre- and post-treatment...
August 2016: Cephalalgia: An International Journal of Headache
David W Dodick
No abstract text is available yet for this article.
December 2015: Cephalalgia: An International Journal of Headache
Esma Dilli, David Dodick
No abstract text is available yet for this article.
August 2016: Cephalalgia: An International Journal of Headache
Matthew S Robbins, Carrie E Robertson, Jessica Ailani, Morris Levin, Deborah I Friedman, David W Dodick
OBJECTIVE: To survey neurology residency program directors (PDs) on trainee exposure, supervision, and credentialing in procedures widely utilized in headache medicine. BACKGROUND: Clinic-based procedures have assumed a prominent role in headache therapy. Headache fellows obtain procedural competence, but reliance on fellowship-trained neurologists cannot match the population eligible for treatments. The inclusion of educational modules and mechanisms for credentialing trainees pursuing procedural competence in residency curricula at individual programs is not known...
January 2016: Headache
David Borsook, David W Dodick
Migraine is a disease that contributes to major disability. Perhaps because migraine attacks are not immediately life-threatening per se and individuals return to a "normal" state between attacks, it is not taken seriously. However, migraine is associated with a number of comorbidities, including psychiatric disease, stroke, and other chronic pain disorders. Current acute treatments for episodic migraine are relatively effective, but preventive treatments for episodic and chronic migraine are far less so. Recent functional imaging studies have shown that the disease affects brain function and structure (either as a result of its genetic predisposition or as a result of repeated attacks)...
August 2015: Neurology. Clinical Practice
Chia-Chun Chiang, Todd J Schwedt, Shuu-Jiun Wang, David W Dodick
INTRODUCTION: The objective of this review is to provide an evidence-based discussion of different treatment strategies for medication-overuse headache (MOH). METHOD: We searched PubMed for articles discussing the treatment and prognosis of MOH published between 2004 and August 2014. Titles, abstract and articles were reviewed systematically. The level of evidence provided by each study of the included articles was determined according to the American Academy of Neurology Clinical practice guideline manual...
April 2016: Cephalalgia: An International Journal of Headache
Richard B Lipton, Daniel Serrano, Dawn C Buse, Jelena M Pavlovic, Andrew M Blumenfeld, David W Dodick, Sheena K Aurora, Werner J Becker, Hans-Christoph Diener, Shuu-Jiun Wang, Maurice B Vincent, Nada A Hindiyeh, Amaal J Starling, Patrick J Gillard, Sepideh F Varon, Michael L Reed
BACKGROUND: Migraine, particularly chronic migraine (CM), is underdiagnosed and undertreated worldwide. Our objective was to develop and validate a self-administered tool (ID-CM) to identify migraine and CM. METHODS: ID-CM was developed in four stages. (1) Expert clinicians suggested candidate items from existing instruments and experience (Delphi Panel method). (2) Candidate items were reviewed by people with CM during cognitive debriefing interviews. (3) Items were administered to a Web panel of people with severe headache to assess psychometric properties and refine ID-CM...
March 2016: Cephalalgia: An International Journal of Headache
Esma Dilli, David W Dodick
No abstract text is available yet for this article.
October 2015: Cephalalgia: An International Journal of Headache
Lyell K Jones, Elliot L Dimberg, Christopher J Boes, Scott D Z Eggers, David W Dodick, Jeremy K Cutsforth-Gregory, Andrea N Leep Hunderfund, David J Capobianco
OBJECTIVE: Beginning in 2014, US neurology residency programs were required to report each trainee's educational progression within 29 neurology Milestone competency domains. Trainee assessment systems will need to be adapted to inform these requirements. The primary aims of this study were to validate neurology resident assessment content using observable practice activities (OPAs) and to develop assessment formats easily translated to the Neurology Milestones. METHODS: A modified Delphi technique was used to establish consensus perceptions of importance of 73 neurology OPAs among neurology educators and trainees at 3 neurology residency programs...
June 2, 2015: Neurology
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