keyword
https://read.qxmd.com/read/38523435/impact-of-headache-frequency-and-preventive-treatment-failure-on-quality-of-life-disability-and-direct-and-indirect-costs-among-individuals-with-episodic-migraine-in-the-united-states
#1
JOURNAL ARTICLE
David W Dodick, Michael L Reed, Lulu Lee, Bridget L Balkaran, Kandavadivu Umashankar, Mousam Parikh, Pranav Gandhi, Dawn C Buse
OBJECTIVE: To evaluate unmet needs among individuals with episodic migraine (EM) in the United States (US). BACKGROUND: Data are limited on the impact of headache frequency (HF) and preventive treatment failure (TF) on the burden of migraine in the US. METHODS: A retrospective, cross-sectional analysis of 2019 National Health and Wellness Survey (NHWS) data was conducted from an opt-in online survey that identified respondents (aged ≥18 years) in the US with self-reported physician-diagnosed migraine...
March 24, 2024: Headache
https://read.qxmd.com/read/38518177/guidelines-of-the-international-headache-society-for-controlled-trials-of-pharmacological-preventive-treatment-for-persistent-post-traumatic-headache-attributed-to-mild-traumatic-brain-injury
#2
JOURNAL ARTICLE
Håkan Ashina, Hans-Christoph Diener, Cristina Tassorelli, Ann I Scher, Richard B Lipton, Patricia Pozo-Rosich, Alexandra J Sinclair, Catherine D Chong, Alan G Finkel, Messoud Ashina, Todd J Schwedt, David W Dodick, Gisela M Terwindt
BACKGROUND: Persistent headache attributed to traumatic injury to the head is divided into two subtypes, one attributed to moderate or severe traumatic injury and another attributed to mild traumatic injury (i.e., concussion). The latter is much more prevalent, in part because more than 90% of cases with traumatic brain injury are classified as mild. The pathophysiology of persistent post-traumatic headache is poorly understood and the underlying mechanisms are likely multifactorial. There is currently no approved treatment specifically for persistent post-traumatic headache, and management strategies rely on medications used for migraine or tension-type headache...
March 2024: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/38485433/national-plans-and-awareness-campaigns-as-priorities-for-achieving-global-brain-health
#3
REVIEW
Sebastian F Winter, Donna Walsh, Coriene Catsman-Berrevoets, Valery Feigin, Frédéric Destrebecq, Suzanne L Dickson, Matilde Leonardi, Volker Hoemberg, Cristina Tassorelli, Maria Teresa Ferretti, Anna Dé, Antonella Santuccione Chadha, Chris Lynch, Sophia Bakhtadze, Deanna Saylor, Soonmyung Hwang, Kevin Rostasy, Benzi M Kluger, Claire Wright, Phyllis C Zee, David W Dodick, Joke Jaarsma, Mayowa O Owolabi, Jelka Zaletel, Tit Albreht, Rajinder K Dhamija, Anne Helme, Joanna Laurson-Doube, Action Amos, Florence K Baingana, Gus A Baker, Francesca Sofia, Orla Galvin, Tadeusz Hawrot
Neurological conditions are the leading cause of death and disability combined. This public health crisis has become a global priority with the introduction of WHO's Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders 2022-2031 (IGAP). 18 months after this plan was adopted, global neurology stakeholders, including representatives of the OneNeurology Partnership (a consortium uniting global neurology organisations), take stock and advocate for urgent acceleration of IGAP implementation...
April 2024: Lancet Global Health
https://read.qxmd.com/read/38477313/evaluation-of-outcomes-of-calcitonin-gene-related-peptide-cgrp-targeting-therapies-for-acute-and-preventive-migraine-treatment-based-on-patient-sex
#4
REVIEW
Frank Porreca, Edita Navratilova, Joe Hirman, Antoinette Maassen van den Brink, Richard B Lipton, David W Dodick
BACKGROUND: Women show increased prevalence and severity of migraine compared to men. Whether small molecule calcitonin gene-related peptide receptor (CGRP-R) antagonists (i.e., gepants) and monoclonal antibodies targeting either the CGRP-R or the CGRP peptide might show sexually dimorphic outcomes for acute and preventive therapy has not been established. METHODS: We conducted a subpopulation analysis of available published data from FDA reviews to evaluate potential sex differences in the response rates of ubrogepant, rimegepant and zavegepant for acute migraine therapy...
March 2024: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/38444905/unraveling-the-directional-relationship-of-sleep-and-migraine-like-pain
#5
JOURNAL ARTICLE
Robson C Lillo Vizin, Caroline M Kopruszinski, Paula M Redman, Hisakatsu Ito, Jill Rau, David W Dodick, Edita Navratilova, Frank Porreca
Migraine and sleep disorders are common co-morbidities. Patients frequently link their sleep to migraine attacks suggesting a potential causal relationship between these conditions. However, whether migraine pain promotes or disrupts sleep or whether sleep disruption can increase the risk of migraine remains unknown. We assessed the potential impact of periorbital allodynia, a measure consistent with migraine-like pain, from multiple preclinical models on sleep quantity and quality. Additionally, we evaluated the possible consequences of sleep deprivation in promoting susceptibility to migraine-like pain...
2024: Brain communications
https://read.qxmd.com/read/38425491/clinical-outcomes-and-tau-pathology-in-retired-football-players-associations-with-diagnosed-and-witnessed-sleep-apnea
#6
JOURNAL ARTICLE
Sarah J Banks, Eukyung Yhang, Yorghos Tripodis, Yi Su, Hillary Protas, Charles H Adler, Laura J Balcer, Charles Bernick, Jesse B Mez, Joseph Palmisano, William B Barr, Jennifer V Wethe, David W Dodick, Michael D Mcclean, Brett Martin, Kaitlin Hartlage, Arlener Turner, Robert W Turner, Atul Malhotra, Michael Colman, Ofer Pasternak, Alexander P Lin, Inga K Koerte, Sylvain Bouix, Jeffrey L Cummings, Martha E Shenton, Eric M Reiman, Robert A Stern, Michael L Alosco
BACKGROUND AND OBJECTIVES: Obstructive sleep apnea (SA) is common in older men and a contributor to negative cognitive, psychiatric, and brain health outcomes. Little is known about SA in those who played contact sports and are at increased risk of neurodegenerative disease(s) and other neuropathologies associated with repetitive head impacts (RHI). In this study, we investigated the frequency of diagnosed and witnessed SA and its contribution to clinical symptoms and tau pathology using PET imaging among male former college and former professional American football players...
April 2024: Neurology. Clinical Practice
https://read.qxmd.com/read/38411625/blood-pressure-elevation-in-erenumab-treated-patients-with-migraine-a-retrospective-real-world-experience
#7
JOURNAL ARTICLE
Nikita Chhabra, Carolyn Mead-Harvey, Christopher A Dodoo, Courtney Iser, Hallie Taylor, Hira Chaudhary, Aimen Vanood, David W Dodick
BACKGROUND: Erenumab is a monoclonal antibody that targets the calcitonin gene-related peptide (CGRP) receptor and is approved for the preventative treatment of migraine in adults. CGRP is involved in the regulation of vasomotor tone under physiologic and pathologic conditions, including hypertension. While there has not been evidence of hypertension in preclinical models or clinical trials, post-marketing data suggest erenumab may be associated with hypertension. This led to a warning in the United States Food and Drug Administration prescribing information for erenumab...
February 27, 2024: Headache
https://read.qxmd.com/read/38407903/patient-sex-in-prescribing-cgrp-receptor-antagonists-for-migraine-reply
#8
JOURNAL ARTICLE
Frank Porreca, David W Dodick
No abstract text is available yet for this article.
February 26, 2024: JAMA Neurology
https://read.qxmd.com/read/38365382/potential-treatment-targets-for-migraine-emerging-options-and-future-prospects
#9
REVIEW
Chia-Chun Chiang, Frank Porreca, Carrie E Robertson, David W Dodick
Migraine is a leading cause of disability worldwide. Despite the recent approval of several calcitonin gene-related peptide-targeted therapies, many people with migraine do not achieve satisfactory headache improvement with currently available therapies and there continues to be an unmet need for effective and tolerable migraine-specific treatments. Exploring additional targets that have compelling evidence for their involvement in modulating migraine pathways is therefore imperative. Potential new therapies for migraine include pathways involved in nociception, regulation of homoeostasis, modulation of vasodilation, and reward circuits...
March 2024: Lancet Neurology
https://read.qxmd.com/read/38307672/emerging-and-future-directions-of-migraine-research-and-treatment
#10
REVIEW
Chia-Chun Chiang, David W Dodick
Despite many migraine-specific treatments that became available over the past 5 years, many patients still suffer from debilitating migraine. Emerging and future directions of migraine research and treatment should consider different aspects including revising the headache diagnostic criteria to reflect disease burden and prognosis, developing biomarkers, including genetic, serum, imaging, and deep phenotyping biomarkers to facilitate personalized medicine for headache treatment. Additionally, research should also emphasize identifying novel treatment targets for drug development...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38180396/pharmacotherapies-for-migraine-and-translating-evidence-from-bench-to-bedside
#11
REVIEW
Messoud Ashina, Jan Hoffmann, Håkan Ashina, Debbie L Hay, Yadira Flores-Montanez, Thien Phu Do, Roberto De Icco, David W Dodick
Migraine is a ubiquitous neurologic disorder that afflicts more than 1 billion people worldwide. Recommended therapeutic strategies include the use of acute and, if needed, preventive medications. During the past 2 decades, tremendous progress has been made in better understanding the molecular mechanisms underlying migraine pathogenesis, which in turn has resulted in the advent of novel medications targeting signaling molecule calcitonin gene-related peptide or its receptor. Here, we provide an update on the rational use of pharmacotherapies for migraine to facilitate more informed clinical decision-making...
January 4, 2024: Mayo Clinic Proceedings
https://read.qxmd.com/read/38165330/association-of-vascular-risk-factors-and-csf-and-imaging-biomarkers-with-white-matter-hyperintensities-in-former-american-football-players
#12
JOURNAL ARTICLE
Monica T Ly, Fatima Tuz-Zahra, Yorghos Tripodis, Charles H Adler, Laura J Balcer, Charles Bernick, Henrik Zetterberg, Kaj Blennow, Elaine R Peskind, Rhoda Au, Sarah J Banks, William B Barr, Jennifer V Wethe, Mark W Bondi, Lisa M Delano-Wood, Robert C Cantu, Michael J Coleman, David W Dodick, Michael D McClean, Jesse B Mez, Joseph Palmisano, Brett Martin, Kaitlin Hartlage, Alexander P Lin, Inga K Koerte, Jeffrey L Cummings, Eric M Reiman, Martha E Shenton, Robert A Stern, Sylvain Bouix, Michael L Alosco
BACKGROUND AND OBJECTIVES: Recent data link exposure to repetitive head impacts (RHIs) from American football with increased white matter hyperintensity (WMH) burden. WMH might have unique characteristics in the context of RHI beyond vascular risk and normal aging processes. We evaluated biological correlates of WMH in former American football players, including markers of amyloid, tau, inflammation, axonal injury, neurodegeneration, and vascular health. METHODS: Participants underwent clinical interviews, MRI, and lumbar puncture as part of the Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy Research Project...
January 23, 2024: Neurology
https://read.qxmd.com/read/38134231/flortaucipir-tau-pet-findings-from-former-professional-and-college-american-football-players-in-the-diagnose-cte-research-project
#13
JOURNAL ARTICLE
Yi Su, Hillary Protas, Ji Luo, Kewei Chen, Michael L Alosco, Charles H Adler, Laura J Balcer, Charles Bernick, Rhoda Au, Sarah J Banks, William B Barr, Michael J Coleman, David W Dodick, Douglas I Katz, Kenneth L Marek, Michael D McClean, Ann C McKee, Jesse Mez, Daniel H Daneshvar, Joseph N Palmisano, Elaine R Peskind, Robert W Turner, Jennifer V Wethe, Gil Rabinovici, Keith Johnson, Yorghos Tripodis, Jeffrey L Cummings, Martha E Shenton, Robert A Stern, Eric M Reiman
INTRODUCTION: Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project. METHOD: We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same-age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES)...
December 22, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38030397/simultaneous-comparisons-of-25-acute-migraine-medications-based-on-10-million-users-self-reported-records-from-a-smartphone-application
#14
JOURNAL ARTICLE
Chia-Chun Chiang, Xuemin Fang, Zsolt Horvath, Francois Cadiou, Alexandre Urani, Weijie Poh, Hiroto Narimatsu, Yu Cheng, David W Dodick
BACKGROUND AND OBJECTIVES: Many acute treatment options exist for migraine. However, large-scale, head-to-head comparisons of treatment effectiveness from real-world patient experience reports are lacking. METHODS: This is a retrospective analysis of 10,842,795 migraine attack records extracted from an e-diary smartphone application between June 30, 2014, and July 2, 2020. We analyzed 25 acute medications among 7 classes-acetaminophen, nonsteroid anti-inflammatory drugs (NSAIDs), triptans, combination analgesics, ergots, antiemetics, and opioids...
December 12, 2023: Neurology
https://read.qxmd.com/read/38016977/identification-of-brain-areas-in-mice-with-peak-neural-activity-across-the-acute-and-persistent-phases-of-post-traumatic-headache
#15
JOURNAL ARTICLE
Megan Rudolph, Caroline Kopruszinski, Chen Wu, Edita Navratilova, Todd J Schwedt, David W Dodick, Frank Porreca, Trent Anderson
BACKGROUND: Post-traumatic headache is very common after a mild traumatic brain injury. Post-traumatic headache may persist for months to years after an injury in a substantial proportion of people. The pathophysiology underlying post-traumatic headache remains unknown but is likely distinct from other headache disorders. Identification of brain areas activated in acute and persistent phases of post-traumatic headache can provide insights into the underlying circuits mediating headache pain...
November 2023: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/37981539/examination-of-parkinsonism-in-former-elite-american-football-players
#16
JOURNAL ARTICLE
Michael L Alosco, Charles H Adler, David W Dodick, Yorghos Tripodis, Laura J Balcer, Charles Bernick, Sarah J Banks, William B Barr, Jennifer V Wethe, Joseph N Palmisano, Brett Martin, Kaitlin Hartlage, Robert C Cantu, Yonas E Geda, Douglas I Katz, Jesse Mez, Jeffery L Cummings, Martha E Shenton, Eric M Reiman, Robert A Stern
BACKGROUND: Former American football players are at risk for chronic traumatic encephalopathy (CTE) which may have parkinsonism as a clinical feature. OBJECTIVE: Former football players were prospectively assessed for parkinsonism. METHODS: 120 former professional football players, 58 former college football players, and 60 same-age asymptomatic men without repetitive head impacts, 45-74 years, were studied using the MDS-UPDRS to assess for parkinsonism, and the Timed Up and Go (TUG)...
March 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/37979595/ubrogepant-for-the-treatment-of-migraine-attacks-during-the-prodrome-a-phase-3-multicentre-randomised-double-blind-placebo-controlled-crossover-trial-in-the-usa
#17
RANDOMIZED CONTROLLED TRIAL
David W Dodick, Peter J Goadsby, Todd J Schwedt, Richard B Lipton, Chengcheng Liu, Kaifeng Lu, Sung Yun Yu, Lawrence Severt, Michelle Finnegan, Joel M Trugman
BACKGROUND: Ubrogepant is a calcitonin gene-related peptide (CGRP) receptor antagonist that is approved for acute treatment of migraine. The prodrome is the earliest phase of a migraine attack and is characterised by non-aura symptoms that precede headache onset. The aim of this trial was to evaluate the efficacy, safety, and tolerability of ubrogepant 100 mg compared with placebo for the acute treatment of migraine when administered during the prodrome. METHODS: This PRODROME trial was a phase 3, multicentre, randomised, double-blind, placebo-controlled, crossover trial of ubrogepant 100 mg conducted at 75 research centres and headache clinics in the USA...
December 16, 2023: Lancet
https://read.qxmd.com/read/37917826/hypersensitivity-to-opening-of-atp-sensitive-potassium-channels-in-post-traumatic-headache
#18
RANDOMIZED CONTROLLED TRIAL
Haidar M Al-Khazali, Rune H Christensen, David W Dodick, Basit Ali Chaudhry, Rami Burstein, Håkan Ashina
OBJECTIVE: To investigate whether levcromakalim (a KATP channel opener) induces migraine-like headache in people with persistent post-traumatic headache who had no known history of migraine. METHODS: In a randomized, double-blind, placebo-controlled, 2-way crossover trial, participants were randomly assigned to receive a 20-minute continuous intravenous infusion of levcromakalim (50 µg/mL) or placebo (isotonic saline) on two separate experimental days with a 1-week wash-out period in between...
November 2023: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/37884869/rethinking-headache-as-a-global-public-health-case-model-for-reaching-the-sdg-3-health-by-2030
#19
REVIEW
Paolo Martelletti, Matilde Leonardi, Messoud Ashina, Rami Burstein, Soo-Jin Cho, Augustina Charway-Felli, David W Dodick, Raquel Gil-Gouveia, Licia Grazzi, Christian Lampl, Antoinette MaassenVanDenBrink, Mia T Minen, Dimos Dimitrios Mitsikostas, Jes Olesen, Mayowa Ojo Owolabi, Uwe Reuter, Elena Ruiz de la Torre, Simona Sacco, Todd J Schwedt, Gianluca Serafini, Nirmal Surya, Cristina Tassorelli, Shuu-Jiun Wang, Yonggang Wang, Tissa Wijeratne, Alberto Raggi
The 2030 Agenda for Sustainable Development sets out, through 17 Sustainable Development Goals (SDGs), a path for the prosperity of people and the planet. SDG 3 in particular aims to ensure healthy lives and promote well-being for all at all ages and includes several targets to enhance health. This review presents a "headache-tailored" perspective on how to achieve SDG 3 by focusing on six specific actions: targeting chronic headaches; reducing the overuse of acute pain-relieving medications; promoting the education of healthcare professionals; granting access to medication in low- and middle-income countries (LMIC); implementing training and educational opportunities for healthcare professionals in low and middle income countries; building a global alliance against headache disorders...
October 27, 2023: Journal of Headache and Pain
https://read.qxmd.com/read/37864847/hypersensitivity-to-pacap-38-in-post-traumatic-headache-a-randomized-clinical-trial
#20
JOURNAL ARTICLE
Haidar M Al-Khazali, Rune H Christensen, David W Dodick, Basit Ali Chaudhry, Faisal Mohammad Amin, Rami Burstein, Håkan Ashina
Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38), known for its role in migraine pathogenesis, has been identified as a novel drug target. Given the clinical parallels between post-traumatic headache (PTH) and migraine, we explored the possible role of PACAP-38 in the pathogenesis of PTH. To this end, we conducted a randomized, double-blind, placebo-controlled, 2-way crossover trial involving adult participants diagnosed with persistent PTH resulting from mild traumatic brain injury. Participants were randomly assigned to receive a 20-minute continuous intravenous infusion of either PACAP-38 (10 pmol/kg/min) or placebo (isotonic saline) on two separate experimental days, with a 1-week wash-out period in between...
October 21, 2023: Brain
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