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https://www.readbyqxmd.com/read/29768956/-express-attenuation-of-trpv1-by-amg-517-after-nerve-injury-promotes-peripheral-axonal-regeneration-in-rats
#1
Juan Bai, F U Liu, Li-Fei Wu, Ya-Fang Wang, Xia-Qing Li
AIMS: The main objective was to investigate the effects of the transient receptor potential cation channel subfamily V member 1 (TRPV1) on nerve regeneration following sciatic transection injury by functional blockage of TRPV1 using AMG-517, a specific blocker of TRPV1. METHODS: AMG-517 was injected into the area surrounding ipsilateral lumbar dorsal root ganglia (DRGs) 30 min after unilateral sciatic nerve transection. The number of sciatic axons and the expression of growth associated protein-43 (GAP-43) and glial fibrillary acidic protein (GFAP) were examined using semi-thin sections, western blot, and immunofluorescence analyses...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29764111/public-spending-on-health-services-and-policy-research-in-canada-a-reflection-on-thakkar-and-sullivan-comment-on-public-spending-on-health-service-and-policy-research-in-canada-the-united-kingdom-and-the-united-states-a-modest-proposal
#2
Owen Adams
Vidhi Thakkar and Terrence Sullivan have done a careful and thought-provoking job in trying to establish comparable estimates of public spending on health services and policy research (HSPR) in Canada, the United Kingdom and the United States. Their main recommendation is a call for an international collaboration to develop common terms and categories of HSPR. This paper raises two additional questions that have an international comparative dimension: There is little doubt that public spending on HSPR represents more than the "tip of the iceberg," but how much more? And how do the countries fare on the uptake of HSPR by decision-makers? I have long speculated that probably as much or more is spent by provincial/territorial governments, regional health authorities, hospitals and other agencies on HSPR activities carried out by consultants in Canada than by the federal, provincial/territorial granting agencies...
September 16, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/29758584/inhibition-of-sympathetic-sprouting-in-ccd-rats-by-lacosamide
#3
Yuying Wang, Fuquan Huo
BACKGROUND: Early hyperexcitability activity of injured nerve/neuron is critical for developing sympathetic nerve sprouting within dorsal root ganglia (DRG). Since lacosamide (LCM), an anticonvulsant, inhibits Na+ channel. The present study tried to test the potential effect of LCM on inhibiting sympathetic sprouting in vivo. METHODS: LCM (50 mg/kg) was daily injected intraperitoneally into rats subjected to chronic compression DRG (CCD), an animal model of neuropathic pain that exhibits sympathetic nerve sprouting, for the 1st 7 days after injury...
May 14, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29758573/-assessment-of-coding-in-german-diagnosis-related-groups-system-in-otorhinolaryngology
#4
Maik Ellies, Berit Anders, Wolfgang Seger
BACKGROUND: Prospective analysis of assessment reports in otorhinolaryngology for the period 01-03-2011 to 31-03-2017 by the Health Advisory Boards in Lower Saxony and Bremen, Germany in relation to coding in the G-DRG-System. MATERIAL AND METHODS: The assessment reports were documented using a standardized database system developed on the basis of the electronic data exchange (DTA) by the Health Advisory Board in Lower Saxony. In addition, the documentation of the assessment reports according to the G-DRG system was used for assessment...
May 14, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29756027/translatome-regulation-in-neuronal-injury-and-axon-regrowth
#5
Meir Rozenbaum, Marek Rajman, Ida Rishal, Indrek Koppel, Sandip Koley, Katalin F Medzihradszky, Juan A Oses-Prieto, Riki Kawaguchi, Paul S Amieux, Alma L Burlingame, Giovanni Coppola, Mike Fainzilber
Transcriptional events leading to outgrowth of neuronal axons have been intensively studied, but the role of translational regulation in this process is not well understood. Here, we use translatome analyses by ribosome pull-down and protein synthesis characterization by metabolic isotopic labeling to study nerve injury and axon outgrowth proteomes in rodent dorsal root ganglia (DRGs) and sensory neurons. We identify over 1600 gene products that are primarily translationally regulated in DRG neurons after nerve injury, many of which contain a 5'UTR cytosine-enriched regulator of translation (CERT) motif, implicating the translation initiation factor Eif4e in the injury response...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29755449/immunization-elicits-antigen-specific-antibody-sequestration-in-dorsal-root-ganglia-sensory-neurons
#6
Manojkumar Gunasekaran, Prodyot K Chatterjee, Andrew Shih, Gavin H Imperato, Meghan Addorisio, Gopal Kumar, Annette Lee, John F Graf, Dan Meyer, Michael Marino, Christopher Puleo, Jeffrey Ashe, Maureen A Cox, Tak W Mak, Chad Bouton, Barbara Sherry, Betty Diamond, Ulf Andersson, Thomas R Coleman, Christine N Metz, Kevin J Tracey, Sangeeta S Chavan
The immune and nervous systems are two major organ systems responsible for host defense and memory. Both systems achieve memory and learning that can be retained, retrieved, and utilized for decades. Here, we report the surprising discovery that peripheral sensory neurons of the dorsal root ganglia (DRGs) of immunized mice contain antigen-specific antibodies. Using a combination of rigorous molecular genetic analyses, transgenic mice, and adoptive transfer experiments, we demonstrate that DRGs do not synthesize these antigen-specific antibodies, but rather sequester primarily IgG1 subtype antibodies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29754969/pathways-to-drg-based-hospital-payment-systems-in-japan-korea-and-thailand
#7
Peter Leslie Annear, Soonman Kwon, Luca Lorenzoni, Stephen Duckett, Dale Huntington, John C Langenbrunner, Yuki Murakami, Changwoo Shon, Ke Xu
Countries in Asia are working towards achieving universal health coverage while ensuring improved quality of care. One element is controlling hospital costs through payment reforms. In this paper we review experiences in using Diagnosis Related Groups (DRG) based hospital payments in three Asian countries and ask if there is an "Asian way to DRGs". We focus first on technical issues and follow with a discussion of implementation challenges and policy questions. We reviewed the literature and worked as an expert team to investigate existing documentation from Japan, Republic of Korea, and Thailand...
May 7, 2018: Health Policy
https://www.readbyqxmd.com/read/29749137/the-effect-of-diagnosis-related-group-payment-system-on-quality-of-care-in-the-field-of-obstetrics-and-gynecology-among-korean-tertiary-hospitals
#8
Yong Wook Jung, Haeyong Pak, Inha Lee, Eui Hyeok Kim
PURPOSE: To examine changes in clinical practice patterns following the introduction of diagnosis-related groups (DRGs) under the fee-for-service payment system in July 2013 among Korean tertiary hospitals and to evaluate its effect on the quality of hospital care. MATERIALS AND METHODS: Using the 2012-2014 administrative database from National Health Insurance Service claim data, we reviewed medical information for 160400 patients who underwent cesarean sections (C-secs), hysterectomies, or adnexectomies at 43 tertiary hospitals...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29747898/trends-of-the-neurosurgical-economy-in-the-united-states
#9
William C Johnson, Ali Seifi
BACKGROUND: The objective of this study was to identify the neurosurgical MS-DRGs highest national bills and to analyze economic, demographic, and patient outcome trends. METHODS: This retrospective cohort study used the Nationwide Inpatient Sample (NIS) database to achieve the results. All MS-DRG codes for the years 2014 were ranked based on total aggregate charges. The highest ranked relevant to neurosurgery were identified and retrospectively reviewed to 2008...
May 7, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29747650/hospital-financing-of-ischaemic-stroke-determinants-of-funding-and-usefulness-of-drg-subcategories-based-on-severity-of-illness
#10
Sarah Dewilde, Lieven Annemans, Hilde Pincé, Vincent Thijs
BACKGROUND: Several Western and Arab countries, as well as over 30 States in the US are using the "All-Patient Refined Diagnosis-Related Groups" (APR-DRGs) with four severity-of-illness (SOI) subcategories as a model for hospital funding. The aim of this study is to verify whether this is an adequate model for funding stroke hospital admissions, and to explore which risk factors and complications may influence the amount of funding. METHODS: A bottom-up analysis of 2496 ischaemic stroke admissions in Belgium compares detailed in-hospital resource use (including length of stay, imaging, lab tests, visits and drugs) per SOI category and calculates total hospitalisation costs...
May 11, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29745833/differential-networking-meta-analysis-of-gastric-cancer-across-asian-and-american-racial-groups
#11
Wentao Dai, Quanxue Li, Bing-Ya Liu, Yi-Xue Li, Yuan-Yuan Li
BACKGROUND: Gastric Carcinoma is one of the most lethal cancer around the world, and is also the most common cancers in Eastern Asia. A lot of differentially expressed genes have been detected as being associated with Gastric Carcinoma (GC) progression, however, little is known about the underlying dysfunctional regulation mechanisms. To address this problem, we previously developed a differential networking approach that is characterized by involving differential coexpression analysis (DCEA), stage-specific gene regulatory network (GRN) modelling and differential regulation networking (DRN) analysis...
April 24, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29742504/mir-142-3p-enhances-cell-viability-and-inhibits-apoptosis-by-targeting-cdkn1b-and-timp3-following-sciatic-nerve-injury
#12
Dong-Mei Wu, Xin Wen, Xin-Rui Han, Shan Wang, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Jun Lu, Yuan-Lin Zheng
BACKGROUND/AIMS: MiRNAs are involved in phenotype modulation of neural cells after peripheral nerve injury. However, the roles of miRNAs on the survival of dorsal root ganglion (DRG) neurons have not yet been fully understood. METHODS: In this study, the expression of miR-142-3p was measured in rat DRGs (L4-L6) during the initial 24 hours post sciatic nerve transection by microarray profiling and quantitative PCR. The functional assays including the cell viability, colony formation, cell cycle and apoptosis assays were performed in miR-142-3p mimic or inhibitor transfected cell lines...
May 4, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29736901/bayesian-logistic-regression-approaches-to-predict-incorrect-drg-assignment
#13
Mani Suleiman, Haydar Demirhan, Leanne Boyd, Federico Girosi, Vural Aksakalli
Episodes of care involving similar diagnoses and treatments and requiring similar levels of resource utilisation are grouped to the same Diagnosis-Related Group (DRG). In jurisdictions which implement DRG based payment systems, DRGs are a major determinant of funding for inpatient care. Hence, service providers often dedicate auditing staff to the task of checking that episodes have been coded to the correct DRG. The use of statistical models to estimate an episode's probability of DRG error can significantly improve the efficiency of clinical coding audits...
May 7, 2018: Health Care Management Science
https://www.readbyqxmd.com/read/29728789/ptdrg1-a-desiccation-response-gene-from-pyropia-tenera-rhodophyta-exhibits-chaperone-function-and-enhances-abiotic-stress-tolerance
#14
Yeonju Na, Ha-Nul Lee, Jiwoong Wi, Won-Joong Jeong, Dong-Woog Choi
Pyropia are commercially valuable marine red algae that grow in the intertidal zone. They are extremely tolerant to desiccation stress. We have previously identified and reported desiccation response genes (DRGs) based on transcriptome analysis of P. tenera. Among them, PtDRG1 encodes a polypeptide of 22.6 kDa that is located in the chloroplast. PtDRG1 does not share sequence homology with any known gene deposited in public database. Transcription of PtDRG1 gene was upregulated by osmotic stress induced by mannitol or H2 O2 as well as desiccation stress, but not by heat...
May 4, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29712513/-express-prenatal-maternal-stress-induces-visceral-hypersensitivity-of-adult-rat-offspring-through-activation-of-cystathionine-%C3%AE-synthase-signaling-in-primary-sensory-neurons
#15
Hong-Jun Wang, Xue Xu, Rui-Hua Xie, Yun-Yun Rui, Ping-An Zhang, Xiao-Jue Zhu, Guang-Yin Xu
Irritable bowel syndrome (IBS) is a disorder of unknown etiology characterized by widespread, chronic abdominal pain associated with altered bowel movements. Increasing amounts of evidence indicate that stressors presented during gestational periods could have long-term effects on the offspring's tissue structure and function, which may predispose to gastrointestinal diseases. The aim of the present study is designed to determine whether prenatal maternal stress (PMS) is a adverse factor affecting gastrointestinal sensitivity and to investigate possible mechanisms underlying PMS-induced visceral hypersensitivity in adult offspring...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29709527/upregulation-of-n-type-calcium-channels-in-the-soma-of-uninjured-dorsal-root-ganglion-neurons-contributes-to-neuropathic-pain-by-increasing-neuronal-excitability-following-peripheral-nerve-injury
#16
Jie Yang, Man-Xiu Xie, Li Hu, Xiao-Fang Wang, Jie-Zhen Mai, Yong-Yong Li, Ning Wu, Cheng Zhang, Jin Li, Rui-Ping Pang, Xian-Guo Liu
N-type voltage-gated calcium (Cav2.2) channels are expressed in the central terminals of dorsal root ganglion (DRG) neurons, and are critical for neurotransmitter release. Cav2.2 channels are also expressed in the soma of DRG neurons, where their function remains largely unknown. Here, we showed that Cav2.2 was upregulated in the soma of uninjured L4 DRG neurons, but downregulated in those of injured L5 DRG neurons following L5 spinal nerve ligation (L5-SNL). Local application of specific Cav2.2 blockers (ω-conotoxin GVIA, 1-100 μM or ZC88, 10-1000 μM) onto L4 and 6 DRGs on the operated side, but not the contralateral side, dose-dependently reversed mechanical allodynia induced by L5-SNL...
April 27, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29704683/rates-of-hospital-readmission-among-medicare-beneficiaries-with-gastrointestinal-bleeding-vary-based-on-etiology-and-comorbidities
#17
Shazia Mehmood Siddique, Shivan J Mehta, James Lewis, Mark D Neuman, Rachel M Werner
BACKGROUND & AIMS: Gastrointestinal bleeding results in significant morbidity, mortality, and healthcare costs in the United States. The Center for Medicare and Medicaid Services' payment reform programs assess quality and value based on rates of hospital readmission for patients with gastrointestinal bleeding, but they identify these patients using Medicare Severity Diagnosis Related Groups (MS-DRGs), which include many types of gastrointestinal bleeding and do not account for the clinical heterogeneity among these patients...
April 25, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29659443/evaluation-of-apoptotic-pathways-in-dorsal-root-ganglion-neurons-following-peripheral-nerve-injury
#18
Rebecca Wiberg, Liudmila N Novikova, Paul J Kingham
Peripheral nerve injuries induce significant sensory neuronal cell death in the dorsal root ganglia (DRG); however, the role of specific apoptotic pathways is still unclear. In this study, we performed peripheral nerve transection on adult rats, after which the corresponding DRGs were harvested at 7, 14, and 28 days after injury for subsequent molecular analyses with quantitative reverse transcription-PCR, western blotting, and immunohistochemistry. Nerve injury led to increased levels of caspase-3 mRNA and active caspase-3 protein in the DRG...
April 13, 2018: Neuroreport
https://www.readbyqxmd.com/read/29657242/diagnosis-related-group-drg-based-case-mix-funding-system-a-promising-alternative-for-fee-for-service-payment-in-china
#19
Cuirong Zhao, Chao Wang, Chengwu Shen, Qian Wang
Fee for services (FFS) is the prevailing method of payment in most Chinese public hospitals. Under this retrospective payment system, medical care providers are paid based on medical services and tend to over-treat to maximize their income, thereby contributing to rising medical costs and uncontrollable health expenditures to a large extent. Payment reform needs to be promptly implemented to move to a prospective payment plan. The diagnosis-related group (DRG)-based case-mix payment system, with its superior efficiency and containment of costs, has garnered increased attention and it represents a promising alternative...
April 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29628832/efficacy-and-safety-of-pulsed-radiofrequency-and-steroid-injection-for-intercostobrachial-neuralgia-in-postmastectomy-pain-syndrome-a-clinical-trial
#20
Beshoy Nabil Fam, Ghada Gamal El-Din El-Sayed, Raafat Mahfouz Reyad, Ikramy Mansour
Background: Breast cancer is a common neoplastic tumor in women, and the postmastectomy pain syndrome has been reported frequently after surgical treatment. The injury of the intercostobrachial nerve is considered the major cause of this type of pain. Purpose: Evaluation of efficacy and safety of pulsed radiofrequency (PRF) and steroid injection on the 2nd and 3rd thoracic (T2 and T3) dorsal root ganglions (DRGs) for intercostobrachial neuralgia (ICBN) postmastectomy...
April 2018: Saudi Journal of Anaesthesia
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