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https://www.readbyqxmd.com/read/29158916/the-involvement-of-%C3%AE-catenin-cox-2-vegf-axis-in-nmda-caused-retinopathy
#1
Dan Ning, Wei Kevin Zhang, Han Tian, Xiao-Jun Li, Min Liu, Yu-Sang Li, He-Bin Tang
NMDA, a molecule that is capable of producing the loss of retinal ganglia cells (RGCs), has been widely studied; however, the detailed mechanism is not yet clarified. Previously, Wnt/β-catenin signaling has been suggested to be involved in the NMDA-induced retinopathy. In addition, previous investigations in our group demonstrated the presence of a Wnt/β-catenin/COX-2 axis in dorsal root ganglions (DRGs). Therefore, here in this paper, we tested whether there is an association of such axis with NMDA-induced RGC loss...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29152818/electrical-stimulation-of-dorsal-root-ganglion-in-the-context-of-pain-a-systematic-review-of-in-vitro-and-in-vivo-animal-model-studies
#2
REVIEW
Ivana Vuka, Katarina Vučić, Tihana Repić, Lejla Ferhatović Hamzić, Damir Sapunar, Livia Puljak
OBJECTIVE: Dorsal root ganglion (DRG) has recently emerged as an attractive target for neuromodulation therapy since primary sensory neurons and their soma in DRGs are important sites for pathophysiologic changes that lead to neuropathic pain. Our aim was to create evidence synthesis about the effects of electrical stimulation of DRG in the context of pain from in vitro and in vivo animal models, analyze methodology and quality of studies in the field. METHODS: For conducting systematic review we searched three data bases: MEDLINE, Embase and Web of Science...
November 20, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29131488/dorsal-root-ganglion-stimulation-used-for-the-treatment-of-chronic-neuropathic-pain-in-the-groin-a-single-center-study-with-long-term-prospective-results-in-34-cases
#3
Matthias Hubert Morgalla, Anil Bolat, Marcos Fortunato, Guilherme Lepski, Bankim Subhash Chander
OBJECTIVE: Chronic neuropathic pain in the groin is a severe condition and difficult to treat. Dorsal root ganglion stimulation (DRGS) covers discrete painful areas precisely with its stimulation power in comparison to spinal cord stimulation (SCS). It was our hypothesis that DRGS provides a long-term relief of chronic groin pain over a period of more than three years. MATERIALS AND METHODS: Patients (age >18 years) with chronic neuropathic groin pain were prospectively examined...
November 13, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29121912/the-exploration-of-medical-resources-utilization-among-inguinal-hernia-repair-in-taiwan-diagnosis-related-groups
#4
Yu-Hua Yan, Chih-Ming Kung, Yi Chen
BACKGROUND: This study centered on differences in medical costs, using the Taiwan diagnosis-related groups (Tw-DRGs) on medical resource utilization in inguinal hernia repair (IHR) in hospitals with different ownership to provide suitable reference information for hospital administrators. METHODS: The 2010-2011 data for three hospitals under different ownership were extracted from the Taiwan National Health Insurance claims database. A retrospective method was applied to analyze the age, sex, length of stay, diagnosis and surgical procedure code, and the change in financial risk of medical costs in IHR cases after introduction of Tw-DRGs...
November 9, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29115943/membrane-protein-nav1-7-contributes-to-the-persistent-post-surgical-pain-regulated-by-p-p65-in-dorsal-root-ganglion-drg-of-smir-rats-model
#5
Zhisong Li, Yaru Li, Jing Cao, Xuemin Han, Weihua Cai, Weidong Zang, Jitian Xu, Wei Zhang
BACKGROUND: Persistent post-surgical pain is a difficult clinical problem. In this study, we intend to explore the mechanism underlying the persistent post-surgical pain in SMIR (skin/muscle incision and retraction) rats. METHODS: First of all, the expression of membrane protein Nav1.7 and p-p65 (Phosphorylation of p65) were detected in ipsilateral L4-6 DRGs of SMIR rats by western-blot and immunostaining. Then with ProTx-II (Nav1.7 blocker) or PDTC (p65 inhibitor) were intrathecally injected while the change of Nav1...
November 7, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29114114/health-professionals-information-for-diagnostics-related-groups-drgs-with-the-use-of-a-website
#6
REVIEW
Aikaterini Bizopoulou, Andrianna Mangita, Costis Chardalias, Panagiotis Coutonias, Marianna Diomidous
Introduction: The aim of this research is to inform the health professionals about the ways of introducing and operating the the Diagnosis Related Groups (DRG's) system in the Hellenic National Health System, through the use of the development technologies. An effort is also made to explore the main dimensions of the implementation of the DRG's system, in specific European-Countries that have both adopted the public coverage schemes and the Bismarck health insurance institutions for countries with extensive experience in their implementation...
September 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29112534/il1%C3%AE-inhibition-contributes-to-the-anti-nociceptive-effects-of-voluntary-exercise-on-ischemia-reperfusion-induced-hypersensitivity
#7
Jessica L Ross, Luis F Queme, Jordan E Lamb, Kathryn J Green, Zachary K Ford, Michael P Jankowski
Issues of peripheral circulation have been increasingly suggested as an underlying cause of musculoskeletal pain in many conditions, including sickle cell anemia and peripheral vascular disease. We have previously shown in our model of transient ischemia and reperfusion injury (I/R) of the forelimb that individual group III and IV muscle afferents display altered chemosensitivity and mechanical thresholds 1 d following injury. Functional alterations corresponded to increased evoked and spontaneous pain-related behaviors and decreased muscle strength and voluntary activity-all actions that echo clinical symptoms of ischemic myalgia...
October 30, 2017: Pain
https://www.readbyqxmd.com/read/29104538/chronic-treatment-with-fluoxetine-induces-sex-dependent-analgesic-effects-and-modulates-hdac2-and-mglu2-expression-in-female-mice
#8
Magda Zammataro, Sara Merlo, Massimo Barresi, Carmela Parenti, Huijuan Hu, Maria A Sortino, Santina Chiechio
Gender and sex differences in pain recognition and drug responses have been reported in clinical trials and experimental models of pain. Among antidepressants, contradictory results have been observed in patients treated with selective serotonin reuptake inhibitors (SSRIs). This study evaluated sex differences in response to the SSRI fluoxetine after chronic administration in the mouse formalin test. Adult male and female CD1 mice were intraperitoneally injected with fluoxetine (10 mg/kg) for 21 days and subjected to pain assessment...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29100502/efficacy-of-nerve-growth-factor-antibody-in-a-knee-osteoarthritis-pain-model-in-mice
#9
Masayuki Miyagi, Tetsuhiro Ishikawa, Hiroto Kamoda, Miyako Suzuki, Gen Inoue, Yoshihiro Sakuma, Yasuhiro Oikawa, Sumihisa Orita, Kentaro Uchida, Kazuhisa Takahashi, Masashi Takaso, Seiji Ohtori
BACKGROUND: Nerve growth factor (NGF) is not only an important factor in nerve growth but also a major contributor to the production of inflammation. It has been reported that inhibiting NGF could reduce several types of pain in several animal models. Here, we aimed to clarify the efficacy of NGF antibody in a knee osteoarthritis (OA) pain model in mice. METHOD: Six-week-old male C57BR/J mice were used (n = 30). Ten mice comprised the control group, which received saline injection into the right knee joints; the other 20 mice comprised the experimental group, which received monoiodoacetate (MIA) injection into the right knee joints...
November 3, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29076123/-diagnosis-related-groups-in-reconstructive-plastic-surgery-of-malignant-head-and-neck-skin-tumours
#10
Oliver Lotter, Manuela Micheel, Patrick Jaminet
Background Diagnosis Related Groups (DRGs) were introduced in Germany as a medico-economic classification system 13 years ago. In this analysis, we looked into the compensation for reconstructive plastic surgery after the excision of malignant head and neck skin tumours by DRGs. Material and methods Four main diagnoses (malignant melanoma, basal cell carcinoma, squamous cell carcinoma, carcinoma in situ) at a maximum of 6 different locations in the head and neck were combined with the following procedures: excision and primary wound closure, excision with temporary soft tissue coverage, split-thickness or full-thickness skin grafting, local, free or regional pedicle flaps, distant flaps as well as combined procedures for coverage...
October 26, 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29072007/-effects-of-electroacupuncture-on-activities-of-satellite-glial-cells-of-dorsal-root-ganglia-in-rats-with-neck-incision-pain
#11
Li-Na Qiao, Lian-Hong Tan, Jiao-Jiao Yang, Qiao-Ling Gao, Jiang Zhu, Pei-Jing Rong, Bing Zhu, Yong-Sheng Yang, Jun-Ling Liu
OBJECTIVE: To observe the effect of electroacupuncture (EA) stimulation of "Futu"(LI 18), etc. on activities of satellite glial cells (SGCs) in the dorsal root ganglia (DRG) in rats with neck-incision pain so as to explore its mechanism underlying reduction of post-surgical pain of thyroidectomy. METHODS: Male SD rats were randomly divided into control, model, EA-Futu (LI 18), EA-Hegu (LI 4)-Neiguan (PC 6), and EA-Zusanli (ST 36)-Yanglingquan (GB 34) groups, with 20 rats in each group...
August 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29070698/transplantation-of-wild-type-mouse-hematopoietic-stem-and-progenitor-cells-ameliorates-deficits-in-a-mouse-model-of-friedreich-s-ataxia
#12
Celine J Rocca, Spencer M Goodman, Jennifer N Dulin, Joseph H Haquang, Ilya Gertsman, Jordan Blondelle, Janell L M Smith, Charles J Heyser, Stephanie Cherqui
Friedreich's ataxia (FRDA) is an incurable autosomal recessive neurodegenerative disease caused by reduced expression of the mitochondrial protein frataxin due to an intronic GAA-repeat expansion in the FXN gene. We report the therapeutic efficacy of transplanting wild-type mouse hematopoietic stem and progenitor cells (HSPCs) into the YG8R mouse model of FRDA. In the HSPC-transplanted YG8R mice, development of muscle weakness and locomotor deficits was abrogated as was degeneration of large sensory neurons in the dorsal root ganglia (DRGs) and mitochondrial capacity was improved in brain, skeletal muscle, and heart...
October 25, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29051514/evidence-for-long-term-sensitization-of-the-bowel-in-patients-with-post-infectious-ibs
#13
D Balemans, S U Mondelaers, V Cibert-Goton, N Stakenborg, J Aguilera-Lizarraga, J Dooley, A Liston, D C Bulmer, P Vanden Berghe, G E Boeckxstaens, M M Wouters
Post-infectious irritable bowel syndrome (PI-IBS) is a common gastrointestinal disorder characterized by persistent abdominal pain despite recovery from acute gastroenteritis. The underlying mechanisms are unclear, although long-term changes in neuronal function, and low grade inflammation of the bowel have been hypothesized. We investigated the presence and mechanism of neuronal sensitization in a unique cohort of individuals who developed PI-IBS following exposure to contaminated drinking water 7 years ago...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29035902/comparison-of-direct-patient-care-costs-and-quality-outcomes-of-the-teaching-and-non-teaching-hospitalist-services-at-a-large-academic-medical-center
#14
Jose A Perez, Melina Awar, Aryan Nezamabadi, Richard Ogunti, Mamta Puppala, Lara Colton, Johanna M Clewing, Sayali Ketkar, Stephen T C Wong, Richard J Robbins
PURPOSE: To compare costs of care and quality outcomes between teaching and non-teaching hospitalist services, while testing the assumption resident-driven care is more expensive. METHOD: Records of inpatients with the top 20 Medicare Severity Diagnosis-Related Groups (MS-DRGs) admitted to the University Teaching Service (UTS) and non-teaching hospitalist service (NTHS) at Houston Methodist Hospital from 2014-2015 were analyzed retrospectively. Direct costs of care, length of stay (LOS), in-hospital mortality (IHM), 30-day readmission rate (30DRR), and consultant utilization were compared between the UTS and NTHS...
October 13, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28983220/similar-cost-savings-of-bundled-payment-initiatives-applied-to-lower-extremity-total-joint-arthroplasty-can-be-achieved-applying-both-models-2-and-3
#15
Allyson Alfonso, Lorraine Hutzler, Bill Robb, Chad Beste, André Blom, Joseph Bosco
BACKGROUND: In an effort to control cost and increase value, Medicare is transitioning from fee-for-service to value-based alternative payment models (APMs). The Bundled Payments for Care Improvement (BPCI) initiative represents one such voluntary APM. BPCI offers four different bundling options: model 1 covers all Diagnosis Related Groups (DRGs) and Models 2-4 cover 48 clinical episodes, including 186 separate DRGs. QUESTIONS/PURPOSES: The purpose of this investigation is to analyze and compare the cost savings achieved by two different BPCI program participants, provider A and provider B, enrolled in different models of BPCI (Models 2 and 3) for lower extremity joint replacements (LEJRs)...
October 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28976422/antisense-oligonucleotides-selectively-suppress-target-rna-in-nociceptive-neurons-of-the-pain-system-and-can-ameliorate-mechanical-pain
#16
Apoorva Mohan, Bethany Fitzsimmons, Hien T Zhao, Yuhong Jiang, Curt Mazur, Eric E Swayze, Holly B Kordasiewicz
There is an urgent need for better treatments for chronic pain, which affects more than 1 billion people worldwide. Antisense oligonucleotides (ASOs) have proven successful in treating children with spinal muscular atrophy, a severe infantile neurological disorder, and several compounds based on ASOs are currently being tested in clinical trials for various neurological disorders. Here we characterize the pharmacodynamic activity of ASOs in spinal cord and dorsal root ganglia (DRG), key tissues for pain signaling...
September 30, 2017: Pain
https://www.readbyqxmd.com/read/28967491/the-impact-of-introducing-a-new-hospital-financing-system-drgs-in-poland-on-hospitalisations-for-atherosclerosis-an-interrupted-time-series-analysis-2004-2012
#17
Elżbieta Buczak-Stec, Paweł Goryński, Aneta Nitsch-Osuch, Krzysztof Kanecki, Piotr Tyszko
OBJECTIVES: Hospital payment based on diagnosis-related groups (DRGs) was introduced in Poland in July 2008. We evaluate the impact of this policy on the frequency of hospitalisation for atherosclerosis in internal medicine units of district hospitals and non-public hospitals in Poland. METHODS: Data were collected between 2004 and 2012 from each district and non-public hospital participating in the General Hospital Morbidity Study (165 hospitals in total). Atherosclerosis was defined using the ICD-10 code I70...
November 2017: Health Policy
https://www.readbyqxmd.com/read/28964253/ricemetasys-for-salt-and-drought-stress-responsive-genes-in-rice-a-web-interface-for-crop-improvement
#18
Maninder Sandhu, V Sureshkumar, Chandra Prakash, Rekha Dixit, Amolkumar U Solanke, Tilak Raj Sharma, Trilochan Mohapatra, Amitha Mithra S V
BACKGROUND: Genome-wide microarray has enabled development of robust databases for functional genomics studies in rice. However, such databases do not directly cater to the needs of breeders. Here, we have attempted to develop a web interface which combines the information from functional genomic studies across different genetic backgrounds with DNA markers so that they can be readily deployed in crop improvement. In the current version of the database, we have included drought and salinity stress studies since these two are the major abiotic stresses in rice...
September 30, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28960653/the-efficacy-and-safety-of-dorsal-root-ganglion-stimulation-as-a-treatment-for-neuropathic-pain-a-literature-review
#19
REVIEW
Conrad Harrison, Sarah Epton, Stana Bojanic, Alexander L Green, James J FitzGerald
OBJECTIVE: Dorsal root ganglion stimulation (DRGS) received its first regulatory approval (CE marking in Europe) in late 2011, and so its use is now almost six years old. Several thousand patients have already been treated, and a landmark trial in lower limb complex regional pain syndrome (CRPS) and causalgia has recently been published. METHODS: In this review we have summarized the literature to date on the use of DRGS in the treatment of neuropathic pain. RESULTS: The results so far are encouraging, with reports of successful use in treating a wide range of indications including postsurgical pain, CRPS, and phantom pain...
September 28, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28951043/the-readmission-rates-in-patients-with-versus-those-without-diabetes-mellitus-at-an-urban-teaching-hospital
#20
Halis Sonmez, Varinder Kambo, Dimiter Avtanski, Larry Lutsky, Leonid Poretsky
OBJECTIVE: We examined the 30-day hospital readmission rates and their association with the admission diagnosis and the length of stay (LOS) in patients with diabetes versus those without diabetes mellitus (DM) in an urban teaching hospital. METHODS: In this retrospective study, we compared the 30-day readmission rates in patients with DM (n=16,266) versus those without DM (n=86,428) at an urban teaching hospital between January 1, 2013, and September 30, 2015. In individuals with a secondary diagnosis of DM, we analyzed the relationship between readmission rates and the ten most common Medicare Severity Diagnosis Related Groups (MS-DRGs)...
July 19, 2017: Journal of Diabetes and its Complications
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