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https://www.readbyqxmd.com/read/29288825/inhibitory-effects-of-aconiti-lateralis-radix-preparata-on-chronic-intermittent-cold-induced-inflammation-in-the-mouse-hypothalamus
#1
Wonnam Kim, Wonil Lee, Jin Gyu Choi, In Gyoung Ju, Yun-Kyung Kim, Tae Hee Lee, Myung Sook Oh
ETHNOPHARMACOLOGICAL RELEVANCE: Aconiti Lateralis Radix Preparata (AR) is the most frequently used herb to generate heat and treat symptoms associated with coldness in Asia. AIMS OF THE STUDY: The hypothalamus is one of the master regulators to maintain constant core body temperature. Chronic exposure to cold stress disturbs homeostatic regulation, gradually resulting in hypothalamic inflammation. This study investigate the effects of AR, on the chronic intermittent cold (CIC)-induced release of pro-inflammatory signaling molecules in the mouse hypothalamus...
December 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29248448/zhen-wu-tang-ameliorates-adenine-induced-chronic-renal-failure-in-rats-regulation-of-the-canonical-wnt4-beta-catenin-signaling-in-the-kidneys
#2
Lei La, Lili Wang, Fei Qin, Jian Jiang, Songqi He, Chunxia Wang, Yuhao Li
ETHNOPHARMACOLOGICAL RELEVANCE: Zhen-wu-tang (ZWT), composed of Radix Aconiti lateralis, Rhizoma Atractylodis macrocephalae, Poria, Radix Paeoniae alba and ginger, is a classic Chinese herbal formula for the treatment of chronic kidney diseases that may cause chronic renal failure (CRF). AIM OF THE STUDY: To better understand its clinical use, this study investigated the effects and underlying mechanisms of action of ZWT on CRF. MATERIALS AND METHODS: CRF was induced by adenine...
December 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29200734/toxicity-and-detoxification-effects-of-herbal-caowu-via-ultra-performance-liquid-chromatography-mass-spectrometry-metabolomics-analyzed-using-pattern-recognition-method
#3
Yan Yan, Aihua Zhang, Hui Dong, Guangli Yan, Hui Sun, Xiuhong Wu, Ying Han, Xijun Wang
Background: Caowu (Radix Aconiti kusnezoffii, CW), the root of Aconitum kusnezoffii Reichb., has widely used clinically in rheumatic arthritis, painful joints, and tumors for thousands of years. However, the toxicity of heart and central nervous system induced by CW still limited the application. Materials and Methods: Metabolomics was performed to identify the sensitive and reliable biomarkers and to characterize the phenotypically biochemical perturbations and potential mechanisms of CW-induced toxicity, and the detoxification by combinatorial intervention of CW with Gancao (Radix Glycyrrhizae) (CG), Baishao (Radix Paeoniae Alba) (CB), and Renshen (Radix Ginseng) (CR) was also analyzed by pattern recognition methods...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29197935/how-to-improve-effectiveness-and-adherence-to-antihypertensive-drug-therapy-central-role-of-dihydropyridinic-calcium-channel-blockers-in-hypertension
#4
REVIEW
Giuliano Tocci, Giovambattista Desideri, Elisa Roca, Calogero Calcullo, Massimo Crippa, Nicola De Luca, Giovanni Vincenzo Gaudio, Laura Maria Lonati, Leo Orselli, Angelo Scuteri, Vito Vulpis, Benedetto Acone, Augusto Zaninelli
Essential hypertension is a complex clinical condition, characterized by multiple and concomitant abnormal activation of different regulatory and contra-regulatory pathophysiological mechanisms, leading to sustained increase of blood pressure (BP) levels. Asymptomatic rise of BP may, indeed, promote development and progression of hypertension-related organ damage, which in turn, increases the risk of major cardiovascular and cerebrovascular events. A progressive and independent relationship has been demonstrated between high BP levels and increased cardiovascular risk, even in the high-to-normal range...
December 2, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29191397/the-inhibitory-effect-of-aconiti-sinomontani-radix-extracts-on-the-proliferation-and-migration-of-human-synovial-fibroblast-cell-line-sw982
#5
Xue Deng, Lu-Ping Zheng, Zhen-Qiang Mu, Rui Lai, Guo-Ping Niu, Liang-Ping Tu, Di Zhu, Yan-Qiu Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Aconiti Sinomontani Radix is frequently used in the treatment of Bi syndrome in traditional Chinese medicine. Several reports indicate that Aconiti Sinomontani Radix has therapeutic effects for rheumatoid arthritis (RA). However, the cellular mode of action is still unclear. To investigate the effect of alkaloid extracts of Aconiti Sinomontani Radix on proliferation and migration of human synovial sarcoma SW982 cells as well as the molecular mechanism underlying...
November 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29082700/-anti-inflammatory-mechanism-analysis-of-antirheumatic-chinese-medicinal-herb-aconiti-radix-based-on-protein-interaction-network
#6
Shi-Chao Zheng, Xiao-Ying Yan, Ju Chen, Shu-Ting Zhao, Chuan-Biao Wen
Inflammation is one of the important risk factors of rheumatic diseases. Aconiti Radix is widely used for the treatment of rheumatism, which has significant anti-inflammatory effects. However, its anti-inflammatory mechanism on molecular level is still not clear. The purpose of this study is to illuminate the anti-inflammatory mechanism of Aconiti Radix based on the protein interaction network (PIN) analysis on molecular network level. The main anti-inflammatory components (aconitine, hypaconitine and mesaconitine) were chosen in this study to obtain the targets of the components and protein-protein information though databases retrieval and construct the PIN of Aconiti Radix...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29048206/analysis-of-the-efficacy-and-safety-of-increasing-the-energy-dose-applied-per-session-by-increasing-the-number-of-shock-waves-in-extracorporeal-lithotripsy-a-prospective-and-comparative-study
#7
José Daniel López-Acón, Alberto Budía Alba, Pilar Bahílo-Mateu, Marta Trassierra-Villa, María de Los Ángeles Conca-Baenas, Domingo de Guzmán Ordaz-Jurado, Francisco Tormo Boronat
PURPOSE: To evaluate the efficacy and safety of increasing the energy dose in treating urinary lithiasis with extracorporeal lithotripsy through an expanded number of Shock Waves Per Session (SWPS). MATERIALS AND METHODS: a randomized, prospective, and comparative study was performed with patients with renal or ureteral lithiasis from 2011 to 2014. Two groups were studied: Group A (n = 136), treated with 3500 SWPS, and Group B (n = 171), subjected to an expanded treatment with 7000 SWPS...
November 15, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29026200/simultaneous-quantification-of-nine-aconitum-alkaloids-in-aconiti-lateralis-radix-praeparata-and-related-products-using-uhplc-qqq-ms-ms
#8
Fan He, Can-Jian Wang, Ying Xie, Chun-Song Cheng, Zhong-Qiu Liu, Liang Liu, Hua Zhou
Aconiti Lateralis Radix Praeparata (Fuzi) is obtained from processed daughter roots of Aconitum carmichaeli, a toxic plant with a high medical value well known in Chinese medicine. In addition to the known toxic alkaloids (aconitine, mesaconitine, and hypaconitine) and bioactive alkaloids (benzoylaconine, benzoylmesaconine, and benzoylhypaconine), three rarely found alkaloids have been previously reported in Fuzi, i.e., yunaconitine, 8-deacetyl-yunaconitine, and crassicauline A, and they were reported in recent years to cause potential risk to patients who took Fuzi or related products...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021704/the-effect-of-red-ginseng-and-ginseng-leaves-on-the-substance-and-energy-metabolism-in-hypothyroidism-rats
#9
Hang Xiao, Cheng Tan, Guanlin Yang, Deqiang Dou
BACKGROUND: Recent studies have revealed that the properties Traditional Chinese Medicine is mostly associated with are substance and energy metabolism. Our study aimed to compare the effect of red ginseng (RG) (warm property) and ginseng leaves (GL; cold property) on the substance and energy metabolism of rats with hypothyroidism. MATERIALS AND METHODS: Rats were administered propylthiouracil intraperitoneally for 20 d to cause hypothyroidism. The reference group was orally administered Aconiti Lateralis Radix Praeparaia [FZ (Fuzi in Chinese)], while both the RG and GL groups were orally administrated crude drugs...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28987949/zingiberis-rhizoma-mediated-enhancement-of-the-pharmacological-effect-of-aconiti-lateralis-radix-praeparata-against-acute-heart-failure-and-the-underlying-biological-mechanisms
#10
Lu Zhang, Xiaohua Lu, Jiabo Wang, Pengyan Li, Haotian Li, Shizhang Wei, Xuelin Zhou, Kun Li, Lifu Wang, Ruilin Wang, Yanling Zhao, Xiaohe Xiao
Aconiti Lateralis Radix Praeparata (Fuzi), a type of Chinese materia medica, has been used to treat acute and chronic heart failure (HF) in traditional Chinese medicine and has been proven in numerous animal studies. It is also well-known that Zingiberis Rhizoma (Ganjiang) is ineffective in the treatment of HF, but it can enhance the anti-HF effect of Fuzi. However, the mechanism underlying this compatibility is still not well investigated. To investigate this mechanism, a model of acute heart failure (AHF) in SD rats induced by propafenone hydrochloride was established in this study...
October 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28933279/zinc-transporter-protein-tzn-1-may-also-play-a-role-in-conidiation-pathway-of-neurospora-crassa-an-insight-using-proteogenomic-approach
#11
Divya Rupa Venkata Pandala, Jogeswar Gadi, Kiranmayi Patnala
Zinc transporter (tzn-1) of Neurospora crassa plays a crucial role in conidiation pathway, as its removal results in aconidiation which was reported in our earlier studies. Present study depicts the role of tzn-1 in conidiation process, by comparing knockout (KO) mutants zinc transporter KO (Δtzn-1) and aconidiating gene KO (Δacon-3) with wild oak ridge (OR) 74 'A' strain by 'Proteo-genomic' approach. Firstly, nine commonly overexpressed protein spots from the two sets (Δtzn-1 to wild and Δacon-3 to wild) were analyzed by combining 2-Dimensional gel electrophoresis (2DE) with Matrix Associated Laser Desorption/Ionization mass spectrometry -Peptide Mass Fingerprint (MALDI-PMF)...
September 19, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28929660/-establishment-of-biological-assess-for-quality-control-of-fuzi-based-on-determination-of-premature-ventricular-contractions-in-rats
#12
Zhi-Hao Zhao, Ding-Kun Zhang, Ming-Quan Wu, Chun-Yu Li, Li-Juan Cao, Ping Zhang, Cui-Zhe Liu, Jia-Bo Wang, Xiao-He Xiao
Aconiti Lateralis Radix (Fuzi) is a toxic traditional Chinese medicine with definite efficacy. In order to improve the quality control of its different prepared products and ensure the security in clinic, it is significant to establish a method of quality evaluation related to clinic adverse effects. Aiming at the important biological marker of early cardiac toxicity reaction, there was no method to detect it. In this manuscript, a novel approach for measuring the minimal toxic dose (MTD) of premature ventricular contractions (PVC) poisoning of rats was established...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28872279/hiv-point-of-care-diagnosis-preventing-misdiagnosis-experience-from-a-pilot-of-rapid-test-algorithm-implementation-in-selected-communes-in-vietnam
#13
REVIEW
Van Thi Thuy Nguyen, Susan Best, Hong Thang Pham, Thi Xuan Lien Troung, Thi Thanh Ha Hoang, Kim Wilson, Thi Hong Hanh Ngo, Xuan Chien, Kim Anh Lai, Duc Duong Bui, Masaya Kato
INTRODUCTION: In Vietnam, HIV testing services had been available only at provincial and district health facilities, but not at the primary health facilities. Consequently, access to HIV testing services had been limited especially in rural areas. In 2012, Vietnam piloted decentralization and integration of HIV services at commune health stations (CHSs). As a part of this pilot, a three-rapid test algorithm was introduced at CHSs. The objective of this study was to assess the performance of a three-rapid test algorithm and the implementation of quality assurance measures to prevent misdiagnosis, at primary health facilities...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28839367/simultaneous-quantitation-of-six-aconitum-alkaloids-and-three-flavonoids-in-the-herb-couple-of-radix-aconiti-lateralis-radix-glycyrrhizae-fuzi-gancao-by-uhplc-esi-ms-ms
#14
Xiao Fu, Rongrong Lu, Songsong Zhao
BACKGROUND: Fuzi-Gancao herb couple is one of the commonly used herb couples involved in the traditional Chinese medicine formulations, with radix aconiti lateralis (Fuzi in Chinese) and radix glycyrrhizae (Gancao in Chinese) as a ratio of 1:1. Alkaloids and flavonoids were considered as the main active ingredients of Fuzi-Gancao herb couple. However, no analytical methods have been reported to quantitatively analyze these activity ingredients in Fuzi-Gancao herb couple simultaneously...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28768766/a-synergistic-role-of-irp1-and-fbxl5-proteins-in-coordinating-iron-metabolism-during-cell-proliferation
#15
Nathan B Johnson, Kathryn M Deck, Christopher P Nizzi, Richard S Eisenstein
Iron-regulatory protein 1 (IRP1) belongs to a family of RNA-binding proteins that modulate metazoan iron metabolism. Multiple mechanisms are employed to control the action of IRP1 in dictating changes in the uptake and metabolic fate of iron. Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2...
September 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28668652/an-integrative-investigation-of-the-toxicity-of-aconiti-kusnezoffii-radix-and-the-attenuation-effect-of-its-processed-drug-using-a-uhplc-q-tof-based-rat-serum-and-urine-metabolomics-strategy
#16
Zhenyu Sui, Qing Li, Lin Zhu, Zhenru Wang, Chunxiao Lv, Ran Liu, Huarong Xu, Bosai He, Zuojing Li, Kaishun Bi
Aconiti kusnezoffii radix (AKR), the root of Aconitum kusnezoffii Reichb., is commonly used in the treatment of the rheumatoid arthritis. However, the clinical application is limited due to its potential toxicity. Therefore, to investigate the mechanism of its potential neurotoxicity and nephrotoxicity, a comprehensive metabolomics study combined with serum biochemistry and histopathology measurements was carried out. A UHPLC-Q-TOF mass spectrometry based metabolomics approach was applied to characterize the AKR toxicity, while the toxicity attenuation effects of Aconiti kusnezoffii radix cocta (AKRC) on Wistar rats were also investigated...
October 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28638869/reducing-toxicity-and-increasing-efficiency-aconitine-with-liquiritin-and-glycyrrhetinic-acid-regulate-calcium-regulatory-proteins-in-rat-myocardial-cell
#17
Yuyan Zhang, Li Yu, Weifeng Jin, Hongjing Fan, Min Li, Tianmei Zhou, Haitong Wan, Jiehong Yang
BACKGROUND: Compatibility of Radix Aconiti Carmichaeli and Liquorice is known to treat heart diseases such as heart failure and cardiac arrhythmias. This work answers the question that whether the active components (Aconitine, Liquiritin and Glycyrrhetinic Acid) of Radix Aconiti Carmichaeli and Liquorice could result in regulating intracellular calcium homeostasis and calcium cycling, and thereby verifies the therapeutic material basis. MATERIALS AND METHODS: The myocardial cells were divided into twelve groups randomly as control group, Aconitine group, nine different dose groups that orthogonal combined with Aconitine, Liquiritin and Glycyrrhetinic Acid, and Verapamil group...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28578259/the-protective-effects-of-compatibility-of-aconiti-lateralis-radix-praeparata-and-zingiberis-rhizoma-on-rats-with-heart-failure-by-enhancing-mitochondrial-biogenesis-via-sirt1-pgc-1%C3%AE-pathway
#18
Xiaohua Lu, Lu Zhang, Pengyan Li, Jiabo Wang, Ruisheng Li, Yinqiu Huang, Mingquan Wu, Houqin Zhou, Yang Li, Shizhang Wei, Kun Li, Haotian Li, Xuelin Zhou, Yanling Zhao, Xiaohe Xiao
Aconiti Lateralis Radix Praeparata ("Fuzi" in Chinese) in combination with Zingiberis Rhizoma ("Ganjiang" in Chinese) is commonly applied for the treatment of heart failure for thousands of years in China. However, its therapeutic mechanism is still poorly defined. This study aimed to investigate whether the compatibility of Fuzi and Ganjiang can protect rats with acute heart failure by enhancing mitochondrial biogenesis via Sirt1/PGC-1α signaling pathway. Hemodynamic parameters, including heart rate and left ventricular maximal rate of pressure rise and decline, were recorded in rats with acute heart failure induced by Propafenone hydrochloride...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28528229/sensitive-uhplc-ms-ms-quantitation-and-pharmacokinetic-comparisons-of-multiple-alkaloids-from-fuzi-beimu-and-single-herb-aqueous-extracts-following-oral-delivery-in-rats
#19
Yanyan Xu, Yamei Li, Pengjie Zhang, Bin Yang, Huanyu Wu, Xuejun Guo, Yubo Li, Yanjun Zhang
Aconiti Lateralis Radix Praeparata- Fritillariae Thunbergii bulbus, namely Fuzi- Beimu in Chinese, is a classic herb pair whose combined administration was prohibited according to the rule of "Eighteen antagonisms". However, incompatibility of Fuzi and Beimu has become controversial because of the application supported by many recorded ancient prescriptions and increasing modern researches and clinical practice. The present study aimed to investigate the pharmacokinetic differences of multiple alkaloids from Fuzi- Beimu and the single herb aqueous extracts following oral delivery in rats...
July 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28527516/a-feasible-economical-and-accurate-analytical-method-for-simultaneous-determination-of-six-alkaloid-markers-in-aconiti-lateralis-radix-praeparata-from-different-manufacturing-sources-and-processing-ways
#20
Yi-Bei Zhang, Juan DA, Jing-Xian Zhang, Shang-Rong Li, Xin Chen, Hua-Li Long, Qiu-Rong Wang, Lu-Ying Cai, Shuai Yao, Jin-Jun Hou, Wan-Ying Wu, De-An Guo
Aconiti Lateralis Radix Praeparata (Fuzi) is a commonly used traditional Chinese medicine in clinic for its potency in restoring yang and rescuing from collapse. Aconiti alkaloids, mainly including monoester-diterpenoidaconitines (MDAs) and diester-diterpenoidaconitines (DDAs), are considered to act as both bioactive and toxic constituents. In the present study, a feasible, economical, and accurate HPLC method for simultaneous determination of six alkaloid markers using the Single Standard for Determination of Multi-Components (SSDMC) method was developed and fully validated...
April 2017: Chinese Journal of Natural Medicines
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