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https://www.readbyqxmd.com/read/28933279/zinc-transporter-protein-tzn-1-may-also-play-a-role-in-conidiation-pathway-of-neurospora-crassa-an-insight-using-proteogenomic-approachusing-proteogenomic-approach
#1
Divya Rupa Venkata Pandala, Jogeswar Gadi, Kiranmayi Patnala
Zinc transporter (tzn-1) of Neurospora crassa plays a crucial role in conidiation pathway, as its removal results in aconidiation which was reported in our earlier studies. Present study depicts the role of tzn-1 in conidiation process, by comparing knockout (KO) mutants zinc transporter KO (Δtzn-1) and aconidiating gene KO (Δacon-3) with wild oak ridge (OR) 74 'A' strain by 'Proteo-genomic' approach. Firstly, nine commonly overexpressed protein spots from the two sets (Δtzn-1 to wild and Δacon-3 to wild) were analyzed by combining 2-Dimensional gel electrophoresis (2DE) with Matrix Associated Laser Desorption/Ionization mass spectrometry -Peptide Mass Fingerprint (MALDI-PMF)...
September 19, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28929660/-establishment-of-biological-assess-for-quality-control-of-fuzi-based-on-determination-of-premature-ventricular-contractions-in-rats
#2
Zhi-Hao Zhao, Ding-Kun Zhang, Ming-Quan Wu, Chun-Yu Li, Li-Juan Cao, Ping Zhang, Cui-Zhe Liu, Jia-Bo Wang, Xiao-He Xiao
Aconiti Lateralis Radix (Fuzi) is a toxic traditional Chinese medicine with definite efficacy. In order to improve the quality control of its different prepared products and ensure the security in clinic, it is significant to establish a method of quality evaluation related to clinic adverse effects. Aiming at the important biological marker of early cardiac toxicity reaction, there was no method to detect it. In this manuscript, a novel approach for measuring the minimal toxic dose (MTD) of premature ventricular contractions (PVC) poisoning of rats was established...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28872279/hiv-point-of-care-diagnosis-preventing-misdiagnosis-experience-from-a-pilot-of-rapid-test-algorithm-implementation-in-selected-communes-in-vietnam
#3
REVIEW
Van Thi Thuy Nguyen, Susan Best, Hong Thang Pham, Thi Xuan Lien Troung, Thi Thanh Ha Hoang, Kim Wilson, Thi Hong Hanh Ngo, Xuan Chien, Kim Anh Lai, Duc Duong Bui, Masaya Kato
INTRODUCTION: In Vietnam, HIV testing services had been available only at provincial and district health facilities, but not at the primary health facilities. Consequently, access to HIV testing services had been limited especially in rural areas. In 2012, Vietnam piloted decentralization and integration of HIV services at commune health stations (CHSs). As a part of this pilot, a three-rapid test algorithm was introduced at CHSs. The objective of this study was to assess the performance of a three-rapid test algorithm and the implementation of quality assurance measures to prevent misdiagnosis, at primary health facilities...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28839367/simultaneous-quantitation-of-six-aconitum-alkaloids-and-three-flavonoids-in-the-herb-couple-of-radix-aconiti-lateralis-radix-glycyrrhizae-fuzi-gancao-by-uhplc-esi-ms-ms
#4
Xiao Fu, Rongrong Lu, Songsong Zhao
BACKGROUND: Fuzi-Gancao herb couple is one of the commonly used herb couples involved in the traditional Chinese medicine formulations, with radix aconiti lateralis (Fuzi in Chinese) and radix glycyrrhizae (Gancao in Chinese) as a ratio of 1:1. Alkaloids and flavonoids were considered as the main active ingredients of Fuzi-Gancao herb couple. However, no analytical methods have been reported to quantitatively analyze these activity ingredients in Fuzi-Gancao herb couple simultaneously...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28768766/a-synergistic-role-of-irp1-and-fbxl5-proteins-in-coordinating-iron-metabolism-during-cell-proliferation
#5
Nathan B Johnson, Kathryn M Deck, Christopher P Nizzi, Richard S Eisenstein
Iron-regulatory protein 1 (IRP1) belongs to a family of RNA-binding proteins that modulate metazoan iron metabolism. Multiple mechanisms are employed to control the action of IRP1 in dictating changes in the uptake and metabolic fate of iron. Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4Fe-4S] cluster by the cytosolic iron-sulfur cluster assembly (CIA) system, converting it into cytosolic aconitase (c-acon), but can also involve iron-mediated degradation of IRP1 by the E3 ligase FBXL5 that also targets IRP2...
September 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28668652/an-integrative-investigation-of-the-toxicity-of-aconiti-kusnezoffii-radix-and-the-attenuation-effect-of-its-processed-drug-using-a-uhplc-q-tof-based-rat-serum-and-urine-metabolomics-strategy
#6
Zhenyu Sui, Qing Li, Lin Zhu, Zhenru Wang, Chunxiao Lv, Ran Liu, Huarong Xu, Bosai He, Zuojing Li, Kaishun Bi
Aconiti kusnezoffii radix (AKR), the root of Aconitum kusnezoffii Reichb., is commonly used in the treatment of the rheumatoid arthritis. However, the clinical application is limited due to its potential toxicity. Therefore, to investigate the mechanism of its potential neurotoxicity and nephrotoxicity, a comprehensive metabolomics study combined with serum biochemistry and histopathology measurements was carried out. A UHPLC-Q-TOF mass spectrometry based metabolomics approach was applied to characterize the AKR toxicity, while the toxicity attenuation effects of Aconiti kusnezoffii radix cocta (AKRC) on Wistar rats were also investigated...
October 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28638869/reducing-toxicity-and-increasing-efficiency-aconitine-with-liquiritin-and-glycyrrhetinic-acid-regulate-calcium-regulatory-proteins-in-rat-myocardial-cell
#7
Yuyan Zhang, Li Yu, Weifeng Jin, Hongjing Fan, Min Li, Tianmei Zhou, Haitong Wan, Jiehong Yang
BACKGROUND: Compatibility of Radix Aconiti Carmichaeli and Liquorice is known to treat heart diseases such as heart failure and cardiac arrhythmias. This work answers the question that whether the active components (Aconitine, Liquiritin and Glycyrrhetinic Acid) of Radix Aconiti Carmichaeli and Liquorice could result in regulating intracellular calcium homeostasis and calcium cycling, and thereby verifies the therapeutic material basis. MATERIALS AND METHODS: The myocardial cells were divided into twelve groups randomly as control group, Aconitine group, nine different dose groups that orthogonal combined with Aconitine, Liquiritin and Glycyrrhetinic Acid, and Verapamil group...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28578259/the-protective-effects-of-compatibility-of-aconiti-lateralis-radix-praeparata-and-zingiberis-rhizoma-on-rats-with-heart-failure-by-enhancing-mitochondrial-biogenesis-via-sirt1-pgc-1%C3%AE-pathway
#8
Xiaohua Lu, Lu Zhang, Pengyan Li, Jiabo Wang, Ruisheng Li, Yinqiu Huang, Mingquan Wu, Houqin Zhou, Yang Li, Shizhang Wei, Kun Li, Haotian Li, Xuelin Zhou, Yanling Zhao, Xiaohe Xiao
Aconiti Lateralis Radix Praeparata ("Fuzi" in Chinese) in combination with Zingiberis Rhizoma ("Ganjiang" in Chinese) is commonly applied for the treatment of heart failure for thousands of years in China. However, its therapeutic mechanism is still poorly defined. This study aimed to investigate whether the compatibility of Fuzi and Ganjiang can protect rats with acute heart failure by enhancing mitochondrial biogenesis via Sirt1/PGC-1α signaling pathway. Hemodynamic parameters, including heart rate and left ventricular maximal rate of pressure rise and decline, were recorded in rats with acute heart failure induced by Propafenone hydrochloride...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28528229/sensitive-uhplc-ms-ms-quantitation-and-pharmacokinetic-comparisons-of-multiple-alkaloids-from-fuzi-beimu-and-single-herb-aqueous-extracts-following-oral-delivery-in-rats
#9
Yanyan Xu, Yamei Li, Pengjie Zhang, Bin Yang, Huanyu Wu, Xuejun Guo, Yubo Li, Yanjun Zhang
Aconiti Lateralis Radix Praeparata- Fritillariae Thunbergii bulbus, namely Fuzi- Beimu in Chinese, is a classic herb pair whose combined administration was prohibited according to the rule of "Eighteen antagonisms". However, incompatibility of Fuzi and Beimu has become controversial because of the application supported by many recorded ancient prescriptions and increasing modern researches and clinical practice. The present study aimed to investigate the pharmacokinetic differences of multiple alkaloids from Fuzi- Beimu and the single herb aqueous extracts following oral delivery in rats...
July 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28527516/a-feasible-economical-and-accurate-analytical-method-for-simultaneous-determination-of-six-alkaloid-markers-in-aconiti-lateralis-radix-praeparata-from-different-manufacturing-sources-and-processing-ways
#10
Yi-Bei Zhang, Juan DA, Jing-Xian Zhang, Shang-Rong Li, Xin Chen, Hua-Li Long, Qiu-Rong Wang, Lu-Ying Cai, Shuai Yao, Jin-Jun Hou, Wan-Ying Wu, De-An Guo
Aconiti Lateralis Radix Praeparata (Fuzi) is a commonly used traditional Chinese medicine in clinic for its potency in restoring yang and rescuing from collapse. Aconiti alkaloids, mainly including monoester-diterpenoidaconitines (MDAs) and diester-diterpenoidaconitines (DDAs), are considered to act as both bioactive and toxic constituents. In the present study, a feasible, economical, and accurate HPLC method for simultaneous determination of six alkaloid markers using the Single Standard for Determination of Multi-Components (SSDMC) method was developed and fully validated...
April 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28466742/effects-of-the-diagnostic-label-schizophrenia-actively-used-or-passively-accepted-on-general-practitioners-views-of-this-disorder
#11
Lorenza Magliano, Antonella Strino, Rosanna Punzo, Roberta Acone, Gaetana Affuso, John Read
BACKGROUND: General practitioners (GPs) play a key role in the care of somatic and psychiatric problems in people diagnosed with schizophrenia (PWS). It is probable that, like other health professionals, GPs are not all free of prejudices toward PWS. In clinical practice, GPs sometimes interact with clients diagnosed with schizophrenia by specialists, passively accepting this diagnosis. Other times, GPs interact with clients having symptoms of schizophrenia but who have not been diagnosed...
May 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28433183/corrigendum-to-comparative-tissue-distribution-and-excretion-study-of-alkaloids-from-herba-ephedrae-radix-aconiti-lateralis-extracts-in-rats-j-pharm-biomed-anal-134-2017-137-142
#12
Mengyue Ren, Shuai Song, Dedong Liang, Weiting Hou, Xiaomei Tan, Jiabo Luo
No abstract text is available yet for this article.
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28412009/shockwave-lithotripsy-with-music-less-painful-and-more-satisfactory-treatment
#13
D G Ordaz Jurado, A Budia Alba, P Bahilo Mateu, M Trassierra Villa, D López-Acón, F Boronat Tormo
INTRODUCTION: The objective of this study was to determine whether listening to music during a session of extracorporeal shockwave lithotripsy (ESWL) improves patients' pain. MATERIAL AND METHOD: A simple, blind randomisation was undertaken of patients with kidney and ureter stones attending an ESWL session of 7,000 waves for the first time, between September and December 2014. One group was given music and the other was not. The age, gender, location of stones (kidney/ureter) were recorded and 2questionnaires: pre ESWL (questionnaire A) and postESWL (questionnaire B)...
April 12, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28387961/chemical-profiling-combined-with-omics-technologies-cp-omics-a-strategy-to-understand-the-compatibility-mechanisms-and-simplify-herb-formulas-in-traditional-chinese-medicines
#14
Tengfei Xu, Zifeng Pi, Shu Liu, Fengrui Song, Zhiqiang Liu
INTRODUCTION: The compatibility mechanisms of formulas in traditional Chinese medicine (TCM) are indistinct. In order to better understand the compatibility mechanisms and the quality control of the formulas, it is necessary to simplify formulas in TCM research. OBJECTIVE: Developing a novel method by multi-analysing the contents of different compounds in formula and inferred simplified formula simultaneously. METHODOLOGY: Chemical profiling combined with "omics" technologies (CP-omics) was employed in the present study...
April 7, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28380388/analysis-of-chemical-constituents-in-an-herbal-formula-jitong-ning-tablet
#15
Di Gao, Baojun Wang, Zhipeng Huo, Yi He, Navaneethakrishnan Polachi, Zhidong Lei, Xiaoxiao Liu, Zhaohui Song, Lian-Wen Qi
Jitong Ning Tablet (JTNT), a traditional Chinese herbal formula, consists of Eucommia ulmodies oliv, Angelicae pubescentis radix, Aconiti radix cocta, Corydalis yanhusuo w.t. wang, Glycyrrhizae radix et rhizoma, Paeoniae radix rubra and Radix puerariae. It has been demonstrated to show protective effects on ankylosing spondylitis and anti-inflammatory effects. The chemical compositions of JTNT, playing a key role in quality control, remain unknown. In this study, an ultra-performance liquid chromatography combined with quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS) method in both positive and negative ion mode was established to investigate the chemical constituents of JTNT formula...
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28336203/is-extracorporeal-shock-wave-lithotripsy-a-current-treatment-for-urolithiasis-a-systematic-review
#16
P Bahílo Mateu, A Budía Alba, E Liatsikos, M Trassierra Villa, J D López-Acón, D de Guzmán Ordaz, F Boronat Tormo
INTRODUCTION: Technological advances have prompted a change in the management of urolithiasis. Endourological techniques are gaining importance because they are highly effective treatments. The aim of this study was to answer the question of whether extracorporeal shock wave lithotripsy (ESWL) is still a competitive alternative compared with other therapeutic modalities. ACQUISITION OF EVIDENCE: We conducted a literature search of articles published in the past 5 years...
September 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28221146/-new-strategies-and-protocols-in-swl
#17
REVIEW
Alberto Budía Alba, Pilar Bahilo Mateu, Guzmán Ordaz Jurado, José Daniel López-Acón, Marta Trassierra Villa, Francisco Boronat Tormo
OBJECTIVE: An update of the new treatment strategies in extracorporeal lithotripsy as a valid therapeutic alternative in the management of urinary calculi. METHODS: We performed a search and review of the most recent literature which responded to the terms "best practices", "update", "optimization", "practice pattern" in lithotripsy. Only articles written in English or Spanish were selected. RESULTS: The use of a stepwise voltage ramping during extracorporeal lithotripsy with or without pause before the first rise of energy, a decreased delivery rates and the use of a higher number of shock waves per session are shown as alternatives to improve the effectiveness with optimum safety profile...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28207902/methamphetamine-treatment-outcomes-among-gay-men-attending-a-lgbti-specific-treatment-service-in-sydney-australia
#18
Toby Lea, Johann Kolstee, Sarah Lambert, Ross Ness, Siobhan Hannan, Martin Holt
Gay and bisexual men (GBM) report higher rates of methamphetamine use compared to heterosexual men, and thus have a heightened risk of developing problems from their use. We examined treatment outcomes among GBM clients receiving outpatient counseling at a lesbian, gay, bisexual, transgender and intersex (LGBTI)-specific, harm reduction treatment service in Sydney, Australia. GBM receiving treatment for methamphetamine use from ACON's Substance Support Service between 2012-15 (n = 101) were interviewed at treatment commencement, and after 4 sessions (n = 60; follow-up 1) and 8 sessions (n = 32; follow-up 2)...
2017: PloS One
https://www.readbyqxmd.com/read/28109903/an-apposition-compound-eye-adapted-for-nocturnal-vision-in-the-moth-midge-clogmia-albipunctata-williston-diptera-psychodidae
#19
Lei-Po Jia, Ai-Ping Liang
Morphology and anatomy, dark/light adaptational changes and optics of the compound eyes of the nocturnal moth midge Clogmia albipunctata (Williston) are studied. Its apposition type of eye consists of approximately 260 well-separated ommatidia. Each ommatidium features a biconvex corneal lens covered by corneal nipples measuring around 17nm in height; a crystalline cone of the acone type; and an open (laterally fused) rhabdom formed by eight retinular cells (R1-R8). The corneal lens, whose biological significance is addressed, is composed of a thick yellow-coloured inner lens unit (ILU) surrounded by a thin, colourless outer lens unit (OLU)...
April 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28107877/demography-and-health-of-village-dogs-in-rural-western-uganda
#20
David Hyeroba, Sagan Friant, Johnson Acon, James Okwee-Acai, Tony L Goldberg
"Village dogs" in developing economies are assumed to be heavily burdened by infectious disease. We followed a cohort of 61 village dogs in rural western Uganda prospectively for fifteen months to measure changes in health and demographic outcomes, and to examine risk factors for morbidity and mortality. The mean (±standard deviation) number of dogs per household was 2.4 (±2.0), of which 56.0% were male and 44.0% female. For females, average age at first estrus was 1.7 (±0.6)years with a mean litter size of 3...
February 1, 2017: Preventive Veterinary Medicine
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