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Rejection sensitivity

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https://www.readbyqxmd.com/read/29676700/impact-of-allograft-nephrectomy-on-second-renal-transplant-outcome
#1
Masaki Muramatsu, Yoji Hyodo, Michael Sheaff, Arun Gupta, Neil Ashman, Atsushi Aikawa, Magdi Yaqoob, Carmelo Puliatti
OBJECTIVES: The impact of allograft nephrectomy on the outcome of a subsequent renal transplant is unclear. This study was conducted to assess the effects of the first allograft nephrectomy on outcomes of a second transplant. MATERIALS AND METHODS: This study included 118 patients who received a second transplant between 1994 and 2015. Before the second transplant, 59 patients did not undergo a first allograft nephrectomy (group A). Group B comprised 59 patients who had undergone a first allograft nephrectomy...
April 20, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29673305/borderline-personality-features-anger-and-intimate-partner-violence-an-experimental-manipulation-of-rejection
#2
Nicholas A Armenti, Julia C Babcock
Individuals with borderline personality features may be susceptible to react to situational stressors with negative and interpersonally maladaptive emotionality (e.g., anger) and aggression. The current study attempted to test two moderated mediation models to investigate dispositional risk factors associated with borderline personality features and intimate partner violence (IPV). Results from an experimental rejection induction paradigm were examined using moderated regression to observe contextual reactions to imagined romantic rejection from a current romantic partner among individuals with borderline personality features...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29673058/pediatric-heart-transplantation-across-a-positive-crossmatch-first-year-results-from-the-ctotc-04-multi-institutional-study
#3
S Webber, A Zeevi, K Mason, L Addonizio, E Blume, A Dipchand, R Shaddy, B Feingold, C Canter, D Hsu, W Mahle, B Armstrong, Y Morrison, D Ikle, H Diop, J Odim
Sensitization is common in pediatric heart transplant candidates and wait list mortality is high. Transplantation across a positive crossmatch may reduce wait time, but is considered high risk. We prospectively recruited consecutive candidates at 8 North American centers. At transplantation, subjects were categorized as non-sensitized or sensitized (presence of ≥1 HLA antibody with MFI ≥1,000 using single antigen beads). Sensitized subjects were further classified as CDC-crossmatch positive or negative and as DSA positive or negative...
April 19, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29672702/the-disappointing-contribution-of-anti-human-leukocyte-antigen-donor-specific-antibodies-characteristics-for-predicting-allograft-loss
#4
Maxime Courant, Jonathan Visentin, Gabriel Linares, Valérie Dubois, Sébastien Lepreux, Gwendaline Guidicelli, Olivier Thaunat, Pierre Merville, Lionel Couzi, Jean-Luc Taupin
Background: Pathogenicity of donor-specific antibodies (DSAs) can be assessed using the single-antigen flow beads (SAFB) assays through mean fluorescence intensity (MFI) with or without serum ethylenediaminetetraacetic acid (EDTA) treatment, measurement of C1q or C3d binding and/or their intragraft detection [graft-bound donor-specific antibody (gDSA)]. We aimed to investigate which of these markers best associates with antibody-mediated rejection (ABMR) and kidney allograft loss at the time of a for-cause biopsy...
April 17, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29670021/study-on-misalignment-angle-compensation-during-scale-factor-matching-for-two-pairs-of-accelerometers-in-a-gravity-gradient-instrument
#5
Xiangqing Huang, Zhongguang Deng, Yafei Xie, Ji Fan, Chenyuan Hu, Liangcheng Tu
A method for automatic compensation of misalignment angles during matching the scale factors of two pairs of the accelerometers in developing the rotating accelerometer gravity gradient instrument (GGI) is proposed and demonstrated in this paper. The purpose of automatic scale factor matching of the four accelerometers in GGI is to suppress the common mode acceleration of the moving-based platforms. However, taking the full model equation of the accelerometer into consideration, the other two orthogonal axes which is the pendulous axis and the output axis, will also sense the common mode acceleration and reduce the suppression performance...
April 18, 2018: Sensors
https://www.readbyqxmd.com/read/29661426/delayed-graft-function-predictive-factors-and-7-year-outcome-of-deceased-donor-kidney-transplant-recipients-with-different-immunologic-profiles
#6
A H D S Quintella, M F Lasmar, R A Fabreti-Oliveira, E Nascimento
BACKGROUND: Delayed graft function (DGF) is the major post-transplant cause of deleterious effects to the allograft and is associated with poor allograft survival. The aim of this study was to report the outcomes of 236 kidney transplant recipients with different immunologic profiles. METHODS: All patients underwent transplantation (2008-2016) with a deceased donor at the University Hospital of the Faculty of Medical Science, Belo Horizonte, Minas Gerais, Brazil...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661424/intravenous-immunoglobulin-and-rituximab-in-hla-highly-sensitized-kidney-transplant-recipients
#7
S Querido, A Weigert, T Adragão, J Henriques, R Birne, P Matias, C Jorge, C Nascimento, M Bruges, D Machado
INTRODUCTION: HLA-sensitized patients are penalized both in the access to kidney transplantation (KT) and, once transplanted, in the incidence of rejections and long-term allograft survival despite aggressive induction and maintenance therapy. METHODS: This study retrospectively evaluates the impact of combining T- and B-cell-depleting agents and intravenous immunoglobulin for induction therapy in 45 highly sensitized KT patients (anti-panel reactive antibodies >60%, positive flow cytometry crossmatch or donor specific antibodies at the time of transplantation)...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29658868/serum-levels-of-mir-155-mir-326-and-mir-133b-as-early-diagnostic-biomarkers-for-the-detection-of-human-acute-heart-allograft-rejection-in-comparison-with-serum-cardiac-troponin-t
#8
Aghil Esmaeili-Bandboni, Jamshid Bagheri, Ali Reza Bakhshandeh, Javad Mohammadnejad, Esmaeil Sadroddiny
BACKGROUND: Acute heart allograft rejection occurs as a result of antibody-mediated rejection that presents during the first month after transplantation. Finding a non-invasive biomarker is essential for diagnosis of heart allograft rejection. In this research, we intended to compare expression levels of several microRNAs across cardiac troponin T levels between rejected patients (who died before one month following transplantation), non-rejected patients (who survived for at least one month after transplantation), and non-transplanted patients (CABG surgery patients)...
March 12, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29651690/community-structure-analysis-of-rejection-sensitive-personality-profiles-a-common-neural-response-to-social-evaluative-threat
#9
Elise D Kortink, Wouter D Weeda, Michael J Crowley, Bregtje Gunther Moor, Melle J W van der Molen
Monitoring social threat is essential for maintaining healthy social relationships, and recent studies suggest a neural alarm system that governs our response to social rejection. Frontal-midline theta (4-8 Hz) oscillatory power might act as a neural correlate of this system by being sensitive to unexpected social rejection. Here, we examined whether frontal-midline theta is modulated by individual differences in personality constructs sensitive to social disconnection. In addition, we examined the sensitivity of feedback-related brain potentials (i...
April 12, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29619933/monitoring-ovarian-cancer-patients-during-chemotherapy-and-follow-up-with-the-serum-tumor-marker-ca125
#10
Suher Othman Abu Hassaan
Cancer antigen 125 (CA125) is frequently used in the routine monitoring of patients with epithelial ovarian cancer (EOC). The potential benefit is based on the assumption that changes in serial concentrations may provide early and reliable information on tumor growth expediting an early and potentially effective treatment. However, it has remained a challenge to interpret increments in concentrations that correlate with increasing tumor burden in the individual patient. It has been hypothesized that CA125 assessment criteria taking the random variation (analytical and biological) into account may have better accuracy and lead-time potential than criteria based only on an arbitrary percentage of increase...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29615678/protein-bound-nad-p-h-lifetime-is-sensitive-to-multiple-fates-of-glucose-carbon
#11
Joe T Sharick, Peter F Favreau, Amani A Gillette, Sophia M Sdao, Matthew J Merrins, Melissa C Skala
While NAD(P)H fluorescence lifetime imaging (FLIM) can detect changes in flux through the TCA cycle and electron transport chain (ETC), it remains unclear whether NAD(P)H FLIM is sensitive to other potential fates of glucose. Glucose carbon can be diverted from mitochondria by the pentose phosphate pathway (via glucose 6-phosphate dehydrogenase, G6PDH), lactate production (via lactate dehydrogenase, LDH), and rejection of carbon from the TCA cycle (via pyruvate dehydrogenase kinase, PDK), all of which can be upregulated in cancer cells...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614033/radio-frequency-detection-and-characterization-of-water-ethanol-solution-through-spiral-coupled-passive-micro-resonator-sensor
#12
Gyan Raj Koirala, Rajendra Dhakal, Eun-Seong Kim, Zhao Yao, Nam-Young Kim
We present a microfabricated spiral-coupled passive resonator sensor realized through integrated passive device (IPD) technology for the sensitive detection and characterization of water-ethanol solutions. In order to validate the performance of the proposed device, we explicitly measured and analyzed the radio frequency (RF) characteristics of various water-ethanol solution compositions. The measured results showed a drift in the resonance frequency from 1.16 GHz for deionized (DI) water to 1.68 GHz for the solution containing 50% ethanol, whereas the rejection level given by the reflection coefficient decreased from -29...
April 3, 2018: Sensors
https://www.readbyqxmd.com/read/29604113/minority-stress-and-relational-mechanisms-of-suicide-among-sexual-minorities-subgroup-differences-in-the-associations-between-heterosexist-victimization-shame-rejection-sensitivity-and-suicide-risk
#13
Ethan H Mereish, Jessica R Peters, Shirley Yen
Despite sexual orientation disparities in suicide, there is limited research examining factors associated with suicide risk among sexual minorities while considering subgroup differences within this group. This study identified differences between sexual minorities at risk for suicide and those not at risk. The study also examined heterosexist victimization, as one form of minority stress, and two relational mechanisms (i.e., shame and rejection sensitivity) as risk factors for suicidality. We examined a moderated-mediation model, in which we tested gender and sexual orientation differences in the mediating effects of the relational mechanisms on the association between heterosexist victimization and suicide risk...
March 31, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29594146/early-conversion-from-tacrolimus-to-belatacept-in-a-highly-sensitized-renal-allograft-recipient-with-calcineurin-inhibitor-induced-de-novo-post-transplant-hemolytic-uremic-syndrome
#14
Vasishta S Tatapudi, Bonnie E Lonze, Ming Wu, Robert A Montgomery
Background: Kidney transplantation is the first-line therapy for patients with end-stage renal disease since it offers greater long-term survival and improved quality of life when compared to dialysis. The advent of calcineurin inhibitor (CNI)-based maintenance immunosuppression has led to a clinically significant decline in the rate of acute rejection and better short-term graft survival rates. However, these gains have not translated into improvement in long-term graft survival. CNI-related nephrotoxicity and metabolic side effects are thought to be partly responsible for this...
January 2018: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29579822/highly-hla-sensitized-kidney-transplant-patients-in-a-transplant-center
#15
P K Garcia, J Toro, C Borda, C Gonzalez, M P Rodriguez, K Contreras
INTRODUCTION: Approximately 10% to 30% of patients on renal transplant waiting lists are sensitized, which gives them more time on the waiting list. Transplantation in this setting has a greater risk of rejection and decreased graft survival. New strategies of donor allocation through virtual crossmatching and optimization of immunosuppressive therapies in induction and maintenance have allowed the allocation of organs for this population, which in other circumstances would not be chosen for a kidney transplant...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29565623/responding-to-gender-and-sexual-minority-stress-with-functional-analytic-psychotherapy
#16
Matthew D Skinta, Brandon Hoeflein, Amanda M Muñoz-Martínez, C Lucía Rincón
Despite an overwhelming literature detailing the impact of societal bias on the well-being and relationships of gender and sexual minority clients, as well as greater rates of help-seeking from mental health professionals, recent advances in minority stress research have not been fully incorporated into clinical practice. Minority stress factors such as internalized stigma, rejection sensitivity, and concealment interfere with vulnerable and intimate relationships, and likely contribute to the transdiagnostic challenges that GSM clients report, such as loneliness and social isolation (Mereish & Poteat, 2015)...
March 2018: Psychotherapy
https://www.readbyqxmd.com/read/29564088/reducing-rates-of-clostridium-difficile-infection-by-switching-to-a-stand-alone-naat-with-clear-sampling-criteria
#17
E Casari, C De Luca, M Calabrò, C Scuderi, C Daleno, A Ferrario
Background: Clostridium difficile infection is an important cause of morbidity and mortality but the optimal method of diagnosis for both patient management and infection prevention remains controversial. Methods: Our hospital made a decision to switch from the use of toxin immunoassay to a stand-alone nucleic acid test. This change was accompanied by the provision of clear sampling guidance and rejection criteria and this study aimed to assess the impact of that change...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29552016/-in-utero-exposure-to-exosomal-and-b-cell-alloantigens-lessens-alloreactivity-of-recipients-lymphocytes-rather-than-confers-allograft-tolerance
#18
Jeng-Chang Chen, Liang-Shiou Ou, Cheng-Chi Chan, Ming-Ling Kuo, Li-Yun Tseng, Hsueh-Ling Chang
According to actively acquired tolerance, antigen exposure before full immune development in fetal or early neonatal life will cause tolerance to this specific antigen. In this study, we aimed to examine whether allogeneic tolerance could be elicited by in utero exposure to surface MHC antigens of allogenic cells or soluble form of MHC exosomes. Gestational day 14 FVB/N fetuses were subjected to intraperitoneal injection of allogeneic major histocompatibility complex (MHC) exosomes or highly enriched B-cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29547816/abnormal-emotional-and-neural-responses-to-romantic-rejection-and-acceptance-in-depressed-women
#19
Ashley A Yttredahl, Erin McRobert, Benjamin Sheler, Brian J Mickey, Tiffany M Love, Scott A Langenecker, Jon-Kar Zubieta, David T Hsu
INTRODUCTION: Responding adaptively to one's social environment is a key factor predicting the course of major depressive disorder (MDD). Socially rejecting events can exacerbate, whereas socially accepting events can ameliorate depressive symptoms. The neural responses to rejection and acceptance in MDD are relatively unexplored. METHODS: We used functional magnetic resonance imaging (fMRI) to measure neural responses to romantic rejection and acceptance in women diagnosed with current MDD (n = 19) and a matched group of healthy controls (HCs) (n = 19)...
July 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29547626/clinical-management-and-outcomes-of-patients-with-hermansky-pudlak-syndrome-pulmonary-fibrosis-evaluated-for-lung-transplantation
#20
Souheil El-Chemaly, Kevin J O'Brien, Steven D Nathan, Gerald L Weinhouse, Hilary J Goldberg, Jean M Connors, Ye Cui, Todd L Astor, Philip C Camp, Ivan O Rosas, Merte Lemma, Vladislav Speransky, Melissa A Merideth, William A Gahl, Bernadette R Gochuico
Pulmonary fibrosis is a progressive, fatal manifestation of Hermansky-Pudlak syndrome (HPS). Some patients with advanced HPS pulmonary fibrosis undergo lung transplantation despite their disease-associated bleeding tendency; others die while awaiting donor organs. The objective of this study is to determine the clinical management and outcomes of a cohort with advanced HPS pulmonary fibrosis who were evaluated for lung transplantation. Six patients with HPS-1 pulmonary fibrosis were evaluated at the National Institutes of Health Clinical Center and one of two regional lung transplant centers...
2018: PloS One
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