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Rejection sensitivity

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https://www.readbyqxmd.com/read/29222866/outcome-of-antibody-mediated-rejection-compared-to-acute-cellular-rejection-after-pediatric-heart-transplantation
#1
Gabrielle R Vaughn, Neal W Jorgensen, Yuk M Law, Erin L Albers, Borah J Hong, Joshua M Friedland-Little, Mariska S Kemna
Outcomes of ACR after pediatric HTx have been well described, but less has been reported on outcomes of AMR. We compared the clinical characteristics and cardiovascular outcomes (composite end-point of death, retransplantation, or allograft vasculopathy) of pediatric HTx recipients with AMR, ACR, and no rejection in a retrospective single-center study of 104 recipients. Twenty were treated for AMR; 15 were treated for ACR. Recipients with AMR had an increased frequency of congenital heart disease (90% vs ACR 67% vs no rejection 59%, P = ...
December 9, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29214847/introducing-a-new-assessment-tool-for-measuring-ethnic-racial-identity-the-cross-ethnic-racial-identity-scale-adult-ceris-a
#2
Frank C Worrell, Rodolfo Mendoza-Denton, Amanda Wang
In this article, we examined the psychometric properties of scores on a new instrument, the Cross Ethnic-Racial Identity Scale-Adult (CERIS-A) for use across different ethnic and racial groups. The CERIS-A measures seven ethnic-racial identity attitudes-assimilation, miseducation, self-hatred, anti-dominant, ethnocentricity, multiculturalist inclusive, and ethnic-racial salience. Participants consisted of 803 adults aged 18 to 76, including African Americans (19.3%), Asian Americans (17.6%), European Americans (37...
March 1, 2017: Assessment
https://www.readbyqxmd.com/read/29214126/pharmacologic-complement-inhibition-in-clinical-transplantation
#3
REVIEW
Vasishta S Tatapudi, Robert A Montgomery
Purpose of Review: Over the past two decades, significant strides made in our understanding of the etiology of antibody-mediated rejection (AMR) in transplantation have put the complement system in the spotlight. Here, we review recent progress made in the field of pharmacologic complement inhibition in clinical transplantation and aim to understand the impact of this therapeutic approach on outcomes in transplant recipients. Recent Findings: Encouraged by the success of agents targeting the complement cascade in disorders of unrestrained complement activation like paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), investigators are testing the safety and efficacy of pharmacologic complement blockade in mitigating allograft injury in conditions ranging from AMR to recurrent post-transplant aHUS, C3 glomerulopathies and antiphospholipid anti-body syndrome (APS)...
2017: Current Transplantation Reports
https://www.readbyqxmd.com/read/29212908/naive-cd4-t-cells-carrying-a-tlr2-agonist-overcome-tgf-%C3%AE-mediated-tumor-immune-evasion
#4
Mohsen Ibrahim, Davide Scozzi, Kelsey A Toth, Donatella Ponti, Daniel Kreisel, Cecilia Menna, Elena De Falco, Antonio D'Andrilli, Erino A Rendina, Antonella Calogero, Alexander S Krupnick, Andrew E Gelman
TLR agonists are effective at treating superficial cancerous lesions, but their use internally for other types of tumors remains challenging because of toxicity. In this article, we report that murine and human naive CD4+ T cells that sequester Pam3Cys4 (CD4+ TPam3) become primed for Th1 differentiation. CD4+ TPam3 cells encoding the OVA-specific TCR OT2, when transferred into mice bearing established TGF-β-OVA-expressing thymomas, produce high amounts of IFN-γ and sensitize tumors to PD-1/programmed cell death ligand 1 blockade-induced rejection...
December 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29210194/error-related-brain-activity-and-anxiety-symptoms-in-youth-with-autism-spectrum-disorder
#5
Tamara E Rosen, Matthew D Lerner
Individuals with autism spectrum disorder (ASD) often experience symptoms associated with generalized anxiety disorder, obsessive-compulsive disorder, and social anxiety disorder. In other populations, these same symptoms are associated with a larger error-related negativity (ERN), an event-related potential that reflects endogenous threat sensitivity. As such, it is possible that the ERN may relate to the clinical presentation of anxiety in ASD. However, studies examining these associations in youth with ASD have yielded mixed results...
December 6, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29200833/positive-airway-pressure-adherence-and-subthreshold-adherence-in-posttraumatic-stress-disorder-patients-with-comorbid-sleep-apnea
#6
Barry J Krakow, Jessica J Obando, Victor A Ulibarri, Natalia D McIver
Study objectives: Patients with comorbid posttraumatic stress disorder (PTSD) and obstructive sleep apnea (OSA) manifest low adherence to continuous positive airway pressure (CPAP) due to fixed, pressure-induced expiratory pressure intolerance (EPI), a subjective symptom and objective sign aggravated by anxiety sensitivity and somatosensory amplification. As advanced PAP therapy modes (ie, auto-bilevel PAP [ABPAP] or adaptive servo-ventilation [ASV]) may address these side effects, we hypothesized such treatment would be associated with decreased expiratory intolerance and increased adherence in posttraumatic stress patients with co-occurring OSA...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29191293/cardiac-transplantation-current-outcomes-and-contemporary-controversies
#7
REVIEW
Michelle M Kittleson, Jon A Kobashigawa
Despite advances in pharmacologic and device treatment of chronic heart failure, long-term morbidity and mortality remain high, and many patients progress to end-stage heart failure. Over the last 5 decades, heart transplantation (HTx) has become the preferred therapy for select patients with end-stage heart disease. However, although HTx has become standard of care for the management of end-stage heart failure, challenges continue to exist. The number of patients with end-stage heart failure is increasing, whereas the number of donor organs remains constant and a limiting factor in HTx...
December 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29189030/a-weekly-diary-study-of-minority-stress-coping-and-internalizing-symptoms-among-gay-men
#8
Brian A Feinstein, Joanne Davila, Christina Dyar
OBJECTIVE: Research has demonstrated that gay men are at increased risk for internalizing disorders compared with heterosexual men and that minority stressors are risk factors. However, the mechanisms underlying the associations between minority stressors and internalizing symptoms remain unclear. The current study examined coping strategies (active and disengaged coping) as mediators of the associations between minority stressors (internalized homonegativity [IH] and rejection sensitivity [RS]) and internalizing symptoms...
December 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29185512/female-cuckoo-calls-misdirect-host-defences-towards-the-wrong-enemy
#9
Jenny E York, Nicholas B Davies
Prey are sensitive to even subtle cues of predation risk, which provides the evolutionary potential for parasites to exploit host risk perception. Brood parasitic common cuckoos (Cuculus canorus) lay their eggs in the nests of host species and their secretive laying behaviour enables them to evade host defences. Therefore, it seems paradoxical that female cuckoos often give a conspicuous 'chuckle' call after parasitizing a host's clutch. Here, we show that this hawk-like chuckle call increases the success of parasitism by diverting host parents' attention away from the clutch and towards their own safety...
October 2017: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29184907/comparative-assessment-of-anti-hla-antibodies-using-two-commercially-available-luminex-based-assays
#10
Kevin J Clerkin, Sarah B See, Maryjane A Farr, Susan W Restaino, Geo Serban, Farhana Latif, Lingzhi Li, Paolo C Colombo, George Vlad, Bryan Ray, Elena R Vasilescu, Emmanuel Zorn
Background: Allospecific anti-HLA antibodies (Abs) are associated with rejection of solid organ grafts. The 2 main kits to detect anti-HLA Ab in patient serum are commercialized by Immucor and One Lambda/ThermoFisher. We sought to compare the performance of both platforms. Methods: Background-adjusted mean fluorescence intensity (MFI) values were used from both platforms to compare sera collected from 125 pretransplant and posttransplant heart and lung transplant recipients...
November 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29179140/modifying-a-negative-interpretation-bias-for-ambiguous-social-scenarios-that-depict-the-risk-of-rejection-in-women-with-anorexia-nervosa
#11
Robert Turton, Valentina Cardi, Janet Treasure, Colette R Hirsch
BACKGROUND: A heightened sensitivity to social rejection might contribute towards the interpersonal difficulties and symptoms that characterise Anorexia Nervosa (AN). This paper examines the effect of Cognitive Bias Modification for Interpretation biases (CBM-I) training on a negative interpretation bias for ambiguous social scenarios that involve the risk of rejection and eating behaviour. METHOD: Women with AN received a single session of CBM-I training to develop a more benign interpretational style or a control condition (which included 50:50 negative and benign resolutions)...
November 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29173632/microbiological-chemical-and-sensory-spoilage-analysis-of-raw-atlantic-cod-gadus-morhua-stored-under-modified-atmospheres
#12
L Kuuliala, Y Al Hage, A-G Ioannidis, M Sader, F-M Kerckhof, M Vanderroost, N Boon, B De Baets, B De Meulenaer, P Ragaert, F Devlieghere
During fish spoilage, microbial metabolism leads to the production of volatile organic compounds (VOCs), characteristic off-odors and eventual consumer rejection. The aim of the present study was to contribute to the development of intelligent packaging technologies by identifying and quantifying VOCs that indicate spoilage of raw Atlantic cod (Gadus morhua) under atmospheres (%v/v CO2/O2/N2) 60/40/0, 60/5/35 and air. Spoilage was examined by microbiological, chemical and sensory analyses over storage time at 4 or 8 °C...
April 2018: Food Microbiology
https://www.readbyqxmd.com/read/29173089/interpersonal-needs-and-psychological-pain-the-role-of-brooding-and-rejection-sensitivity
#13
Mary K Lear, Stephanie E Stacy, Carolyn M Pepper
The Interpersonal Theory of Suicide proposes that thwarted belongingness (TB) and perceived burdensomeness (PB) predict psychological pain and desire for suicide. Brooding may be a mechanism in explaining how TB and PB predict pain. The conceptual similarity between rejection sensitivity (RS) and TB suggests that individuals with high RS may be likely to experience psychological pain in the context of TB. To test this model, 155 college students completed measures of psychological pain, TB, PB, brooding, and RS...
November 27, 2017: Death Studies
https://www.readbyqxmd.com/read/29168192/seeing-it-differently-self-reported-description-of-vision-loss-in-dry-age-related-macular-degeneration
#14
Deanna J Taylor, Laura A Edwards, Alison M Binns, David P Crabb
PURPOSE: A realistic description of visual symptoms associated with dry age-related macular degeneration (AMD) is important for raising awareness of the condition and educating patients. This study aimed to develop a set of descriptors for dry AMD and examine the realism of images currently and frequently used to show visual symptoms of the condition. METHODS: Volunteers with dry AMD with a range of disease severity were given an eye examination and were asked to describe visual symptoms of their condition in a conversational interview...
November 23, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29162175/reward-sensitivity-impulse-control-and-social-cognition-as-mediators-of-the-link-between-childhood-family-adversity-and-externalizing-behavior-in-eight-countries
#15
Jennifer E Lansford, Jennifer Godwin, Marc H Bornstein, Lei Chang, Kirby Deater-Deckard, Laura Di Giunta, Kenneth A Dodge, Patrick S Malone, Paul Oburu, Concetta Pastorelli, Ann T Skinner, Emma Sorbring, Laurence Steinberg, Sombat Tapanya, Liane Peña Alampay, Liliana Maria Uribe Tirado, Suha M Al-Hassan, Dario Bacchini
Using data from 1,177 families in eight countries (Colombia, Italy, Jordan, Kenya, the Philippines, Sweden, Thailand, and the United States), we tested a conceptual model of direct effects of childhood family adversity on subsequent externalizing behaviors as well as indirect effects through psychological mediators. When children were 9 years old, mothers and fathers reported on financial difficulties and their use of corporal punishment, and children reported perceptions of their parents' rejection. When children were 10 years old, they completed a computerized battery of tasks assessing reward sensitivity and impulse control and responded to questions about hypothetical social provocations to assess their hostile attributions and proclivity for aggressive responding...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29162003/feedforward-approximations-to-dynamic-recurrent-network-architectures
#16
Dylan R Muir
Recurrent neural network architectures can have useful computational properties, with complex temporal dynamics and input-sensitive attractor states. However, evaluation of recurrent dynamic architectures requires solving systems of differential equations, and the number of evaluations required to determine their response to a given input can vary with the input or can be indeterminate altogether in the case of oscillations or instability. In feedforward networks, by contrast, only a single pass through the network is needed to determine the response to a given input...
November 21, 2017: Neural Computation
https://www.readbyqxmd.com/read/29157328/peer-effects-on-self-regulation-in-adolescence-depend-on-the-nature-and-quality-of-the-peer-interaction
#17
Kevin M King, Katie A McLaughlin, Jennifer Silk, Kathryn C Monahan
Adolescence is a critical period for the development of self-regulation, and peer interactions are thought to strongly influence regulation ability. Simple exposure to peers has been found to alter decisions about risky behaviors and increase sensitivity to rewards. The link between peer exposure and self-regulation is likely to vary as a function of the type and quality of peer interaction (e.g., rejection or acceptance). Little is known about how the nature of interactions with peers influences different dimensions of self-regulation...
November 21, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29156587/a-subnano-g-electrostatic-force-rebalanced-flexure-accelerometer-for-gravity-gradient-instruments
#18
Shitao Yan, Yafei Xie, Mengqi Zhang, Zhongguang Deng, Liangcheng Tu
A subnano-g electrostatic force-rebalanced flexure accelerometer is designed for the rotating accelerometer gravity gradient instrument. This accelerometer has a large proof mass, which is supported inversely by two pairs of parallel leaf springs and is centered between two fixed capacitor plates. This novel design enables the proof mass to move exactly along the sensitive direction and exhibits a high rejection ratio at its cross-axis directions. Benefiting from large proof mass, high vacuum packaging, and air-tight sealing, the thermal Brownian noise of the accelerometer is lowered down to less than 0...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29153775/weekly-paclitaxel-and-carboplatin-plus-bevacizumab-as-first-line-treatment-of-metastatic-triple-negative-breast-cancer-a%C3%A2-multicenter-phase-ii-trial-by-the-hellenic-oncology-research-group
#19
Emmanouil Saloustros, Michail Nikolaou, Konstantinos Kalbakis, Aris Polyzos, Charalampos Christofillakis, Nikolaos Kentepozidis, Nikolaos Pistamaltzian, Charalampos Kourousis, Lampros Vamvakas, Vasilios Georgoulias, Dimitris Mavroudis
BACKGROUND: Triple-negative breast cancer (TNBC) lacks a standard targeted therapeutic strategy and is treated with conventional cytotoxic agents. Because of the sensitivity of TNBC to platinum compounds and the synergistic effect of bevacizumab with paclitaxel we investigated the efficacy and toxicity of weekly paclitaxel and carboplatin in combination with bevacizumab as first-line treatment in metastatic TNBC. PATIENTS AND METHODS: This phase II study followed the Simon's 2-stage optimal design...
October 24, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29152860/-pretty-pressure-from-peers-parents-and-the-media-a-longitudinal-study-of-appearance-based-rejection-sensitivity
#20
Haley J Webb, Melanie J Zimmer-Gembeck, Allison M Waters, Lara J Farrell, Drew Nesdale, Geraldine Downey
Drawing from the tripartite sociocultural model of body image, the researchers examined whether direct messages and modeling from peers, parents, and media were concurrently and prospectively associated with appearance-based rejection sensitivity (appearance-RS) in young adolescents (Mage  = 12.0 years). Appearance-RS was higher among those who concurrently reported more appearance-related teasing and pressure by peers, more parent teasing, and greater acceptance of media appearance ideals. In prospective analyses, greater increases in appearance-RS over 1 year were found for adolescents who perceived higher levels of parental appearance-related teasing and negative attitudes about their own appearance...
December 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
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