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https://www.readbyqxmd.com/read/28930957/clot-dynamics-and-mortality-the-ma-r-ratio
#1
Stephanie A Savage, Ben L Zarzaur, Timothy H Pohlman, Brian L Brewer, Louis J Magnotti, Martin A Croce, Garrett H Lim, Ali C Martin
INTRODUCTION: The coagulopathy of trauma, illustrated by a short R-time, is common and well understood. The physiology behind this may be early thrombin burst with rapid clot formation. Rapid consumption of fibrinogen, however, may result in weak clot and substrate depletion, resulting in low MA. While these characteristics are interesting, utilizing thromboelastography (TEG) to identify those at risk of subsequent bleeding diathesis, especially in those who do not demonstrate early signs of physiologic derangement, is challenging...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930876/case-study-sleep-and-injury-in-elite-soccer-a-mixed-method-approach
#2
Mathieu Nédélec, Cédric Leduc, Brian Dawson, Gaël Guilhem, Grégory Dupont
The present case study allowed an examination of the link between sleep and injury occurrence in an elite male soccer player competing in French League 1 and Union of European Football Associations matches. During 4 months, a mixed method approach was used, combining actigraphic sleep assessment with qualitative interviews on a daily basis. Three injuries were reported over the study period. Sleep onset latency, both in the single night (117±43 min) and in the week (78±50 min) before injury occurrence, was longer than pre-season baseline values (18±13 min; effect size (ES): 3...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28930052/portrayal-of-alcohol-brands-popular-among-underage-youth-on-youtube-a-content-analysis
#3
Brian A Primack, Jason B Colditz, Eva B Rosen, Leila M Giles, Kristina M Jackson, Kevin L Kraemer
OBJECTIVE: We characterized leading YouTube videos featuring alcohol brand references and examined video characteristics associated with each brand and video category. METHOD: We systematically captured the 137 most relevant and popular videos on YouTube portraying alcohol brands that are popular among underage youth. We used an iterative process to codebook development. We coded variables within domains of video type, character sociodemographics, production quality, and negative and positive associations with alcohol use...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28927951/definitive-airway-management-after-pre-hospital-supraglottic-airway-insertion-outcomes-and-a-management-algorithm-for-trauma-patients
#4
Matthew C Hernandez, Johnathon M Aho, Martin D Zielinski, Scott P Zietlow, Brian D Kim, David S Morris
BACKGROUND: Prehospital airway management increasingly involves supraglottic airway insertion and a paucity of data evaluates outcomes in trauma populations. We aim to describe definitive airway management in traumatically injured patients who necessitated prehospital supraglottic airway insertion. METHODS: We performed a single institution retrospective review of multisystem injured patients (≥15years) that received prehospital supraglottic airway insertion during 2009 to 2016...
September 16, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28926999/depression-and-risk-of-unintentional-injury-in-rural-communities-a-longitudinal-analysis-of-the-australian-rural-mental-health-study
#5
Kerry J Inder, Elizabeth G Holliday, Tonelle E Handley, Lyn J Fragar, Tony Lower, Angela Booth, Terry J Lewin, Brian J Kelly
Limited longitudinal research has examined relationships between depression and injury, particularly in rural contexts. This paper reports cross-sectional and longitudinal analyses from the Australian Rural Mental Health Study (ARMHS) exploring relationships between "probable depression" episodes and unintentional injury. Participants completed four surveys over five years. Multivariate logistic regressions were employed to assess the causal effect of prior depression episodes on subsequent injury risk. Of 2621 baseline participants, 23...
September 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28926480/postconcussive-symptoms-over-the-first-14-days-after-mild-traumatic-brain-injury-an-experience-sampling-study
#6
Maria Pacella, Arjun Prabhu, Julia Morley, Stephanie Huang, Brian Suffoletto
OBJECTIVE: This study examined changes in postconcussive symptoms (PCS) over the acute postinjury recovery period, focusing on how daily PCSs differ between mild traumatic brain injury (mTBI) and other injury types. SETTING: An urban emergency department (ED) in Western Pennsylvania. SUBJECTS: A total of 108 adult patients with trauma being discharged from the ED were recruited and grouped by injury type: mild TBI (mTBI; n = 39), head injury without mTBI (HI: n = 16), and non-head-injured trauma controls (TCs: n = 53)...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28924145/a-novel-mouse-model-of-traumatic-optic-neuropathy-using-external-ultrasound-energy-to-achieve-focal-indirect-optic-nerve-injury
#7
Wensi Tao, Galina Dvoriantchikova, Brian C Tse, Steven Pappas, Tsung-Han Chou, Manuel Tapia, Vittorio Porciatti, Dmitry Ivanov, David T Tse, Daniel Pelaez
Traumatic optic neuropathy (TON) is a devastating cause of permanent visual loss following blunt injury to the head. Animal models for TON exist, but most fail to recapitulate the clinical scenario of closed head indirect trauma to the nerve and subsequent neurodegeneration. Thus, we developed a clinically-relevant animal model for TON using a novel ultrasonic pulse injury modality (sonication-induced TON; SI-TON). To trigger TON, a microtip probe sonifier was placed on the supraorbital ridge directly above the entrance of the optic nerve into the bony canal...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922185/a-pilot-study-to-precisely-quantify-forces-applied-by-sonographers-while-scanning-a-step-toward-reducing-ergonomic-injury
#8
Manish Dhyani, Shawn C Roll, Matthew W Gilbertson, Melanie Orlowski, Arash Anvari, Qian Li, Brian Anthony, Anthony E Samir
BACKGROUND: There is a significantly high rate of work-related musculsokeletal injuries in sonography professionals. To date, assessment of risk factors for work- related injuries in sonographers has been based primarily on surveys, subjective reports, and observational methods. There is a need to develop quantitative techniques to better understand risk factors and develop preventive interventions. OBJECTIVE: We pilot tested a high-resolution force-measuring probe capable of precisely measuring forces applied through the transducer by sonographers and used this novel direct measurement technique to evaluate forces during abdominal imaging...
September 14, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28917714/mitochondria-in-the-nervous-system-from-health-to-disease-part-i
#9
EDITORIAL
Brian M Polster, Maria Teresa Carrì, Philip M Beart
In Part I of this Special Issue on "Mitochondria in the Nervous System: From Health to Disease", the editors bring together contributions from experts in brain mitochondrial research to provide an up-to-date overview of mitochondrial functioning in physiology and pathology. The issue provides cutting edge reviews on classical areas of mitochondrial biology that include energy substrate utilization, calcium handling, mitochondria-endoplasmic reticulum communication, and cell death regulation. Additional reviews and original research articles touch upon key mitochondrial defects seen across multiple neurodegenerative conditions, including fragmentation, loss of respiratory capacity, calcium overload, elevated reactive oxygen species generation, perturbed NAD(+) metabolism, altered protein acetylation, and compromised mitophagy...
September 13, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28917207/exposure-to-ambient-air-pollution-and-the-incidence-of-dementia-a-population-based-cohort-study
#10
Hong Chen, Jeffrey C Kwong, Ray Copes, Perry Hystad, Aaron van Donkelaar, Karen Tu, Jeffrey R Brook, Mark S Goldberg, Randall V Martin, Brian J Murray, Andrew S Wilton, Alexander Kopp, Richard T Burnett
INTRODUCTION: Emerging studies have implicated air pollution in the neurodegenerative processes. Less is known about the influence of air pollution, especially at the relatively low levels, on developing dementia. We conducted a population-based cohort study in Ontario, Canada, where the concentrations of pollutants are among the lowest in the world, to assess whether air pollution exposure is associated with incident dementia. METHODS: The study population comprised all Ontario residents who, on 1 April 2001, were 55-85years old, Canadian-born, and free of physician-diagnosed dementia (~2...
September 13, 2017: Environment International
https://www.readbyqxmd.com/read/28916535/spinal-cord-perfusion-pressure-predicts-neurologic-recovery-in-acute-spinal-cord-injury
#11
Jordan W Squair, Lise M Bélanger, Angela Tsang, Leanna Ritchie, Jean-Marc Mac-Thiong, Stefan Parent, Sean Christie, Christopher Bailey, Sanjay Dhall, John Street, Tamir Ailon, Scott Paquette, Nicolas Dea, Charles G Fisher, Marcel F Dvorak, Christopher R West, Brian K Kwon
OBJECTIVE: To determine whether spinal cord perfusion pressure (SCPP) as measured with a lumbar intrathecal catheter is a more predictive measure of neurologic outcome than the conventionally measured mean arterial pressure (MAP). METHODS: A total of 92 individuals with acute spinal cord injury were enrolled in this multicenter prospective observational clinical trial. MAP and CSF pressure (CSFP) were monitored during the first week postinjury. Neurologic impairment was assessed at baseline and at 6 months postinjury...
September 15, 2017: Neurology
https://www.readbyqxmd.com/read/28914680/outcomes-in-patients-treated-with-a-novel-simple-method-for-hemostasis-of-dermal-avulsion-injuries
#12
Sean Taylor Dowling, Brian Wai Lin
OBJECTIVE: A recently described technique proposes a simple method to achieve permanent hemostasis of distal fingertip dermal avulsion injuries. It is simple to learn and easy to perform with readily available materials found in most emergency departments. However, long-term outcomes for patients treated with this technique have not yet been evaluated. A primary objective of the current article is to provide safety data for the technique using an off-label product indication. SETTING: Emergency department of Kaiser Permanente Medical Center, San Francisco, California...
October 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28912380/exposure-of-neonatal-mice-to-bromine-impairs-their-alveolar-development-and-lung-function
#13
Tamas Jilling, Changchun Ren, Aaron Jefthy Yee, Saurabh Aggarwal, Brian Halloran, Namasivayam Ambalavanan, Sadis Matalon
The halogen bromine (Br2) is used extensively in industry and stored and transported in large quantities. Its accidental or malicious release into the atmosphere has resulted in significant casualties. The pathophysiology of Br2-induced lung injury has been studied in adult animals, but the consequences of Br2 exposure to the developing lung are completely unknown. We exposed neonatal mouse littermates on postnatal day 3 (P3) to either Br2 at 400 ppm for 30 minutes (400/30), to Br2 at 600 ppm for 30 minutes (600/30), or to room air, then returned them to their dams and observed until P14...
September 14, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28910483/traumatic-brain-injury-management-in-prolonged-field-care
#14
David van Wyck, Paul E Loos, Nathan Friedline, Drew Stephens, Brian C Smedick, Randall McCafferty, Stephen C Rush, Sean Keenan, Douglas Powell, Stacy Shackelford
No abstract text is available yet for this article.
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28902848/the-effect-of-hiv-infection-and-hcv-viremia-on-inflammatory-mediators-and-hepatic-injury-the-women-s-interagency-hiv-study
#15
Sheila M Keating, Jennifer L Dodge, Philip J Norris, John Heitman, Stephen J Gange, Audrey L French, Marshall J Glesby, Brian R Edlin, Patricia S Latham, Maria C Villacres, Ruth M Greenblatt, Marion G Peters
Hepatitis C virus infection induces inflammation and while it is believed that HIV co-infection enhances this response, HIV control may reduce inflammation and liver fibrosis in resolved or viremic HCV infection. Measurement of systemic biomarkers in co-infection could help define the mechanism of inflammation on fibrosis and determine if HIV control reduces liver pathology. A nested case-control study was performed to explore the relationship of systemic biomarkers of inflammation with liver fibrosis in HCV viremic and/or seropositive women with and without HIV infection...
2017: PloS One
https://www.readbyqxmd.com/read/28901946/design-of-semg-assembly-to-detect-external-anal-sphincter-activity-a-proof-of-concept
#16
Arsam Shiraz, Brian Leaker, Charles Alexander Mosse, Eskinder Solomon, Michael Craggs, Andreas Demosthenous
Conditional trans-rectal stimulation of the pudendal nerve could provide a viable solution to treat hyperreflexive bladder in spinal cord injury. A set threshold of the amplitude estimate of the external anal sphincter surface electromyography (sEMG) may be used as the trigger signal. The efficacy of such a device should be tested in a large scale clinical trial. As such a probe should remain in situ for several hours while patients attend to their daily routine, the recording electrodes should be designed to be large enough to maintain good contact while observing design constraints...
September 13, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28895928/collaborative-visual-analytics-a-health-analytics-approach-to-injury-prevention
#17
Samar Al-Hajj, Brian Fisher, Jennifer Smith, Ian Pike
Background: Accurate understanding of complex health data is critical in order to deal with wicked health problems and make timely decisions. Wicked problems refer to ill-structured and dynamic problems that combine multidimensional elements, which often preclude the conventional problem solving approach. This pilot study introduces visual analytics (VA) methods to multi-stakeholder decision-making sessions about child injury prevention; Methods: Inspired by the Delphi method, we introduced a novel methodology-group analytics (GA)...
September 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28895621/optimum-drop-jump-height-in-division-iii-athletes-under-75-of-vertical-jump-height
#18
Hsien-Te Peng, Cong Toai Khuat, Thomas W Kernozek, Brian J Wallace, Shin-Liang Lo, Chen-Yi Song
Our purpose was to evaluate the vertical ground reaction force, impulse, moments and powers of hip, knee and ankle joints, contact time, and jump height when performing a drop jump from different drop heights based on the percentage of a performer's maximum vertical jump height (MVJH). Fifteen male Division III athletes participated voluntarily. Eleven synchronized cameras and two force platforms were used to collect data. One-way repeated-measures analysis of variance tests were used to examine the differences between drop heights...
September 11, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28895461/skeletal-muscle-atrophy-and-degeneration-in-a-mouse-model-of-traumatic-brain-injury
#19
Bahar Shahidi, Sameer B Shah, Mary Esparza, Brian Patrick Head, Sam Ward
Atrophy is thought to be a primary mode of muscle loss in neuromuscular injuries. The differential effects of central and peripheral injuries on atrophy and degeneration/regeneration in skeletal muscle tissue have not been well described. This study investigated skeletal muscle atrophy and degeneration/regeneration in an animal model of traumatic brain injury (TBI). Eight 8-month old wild type C57BL6 mice underwent either a sham craniotomy or TBI targeting the motor cortex. Atrophy (Fiber Area; FA) and degeneration/regeneration (Centralized Nuclei proportions; CN) of the Soleus and Tibialis Anterior (TA) muscles were measured 2 months post injury...
September 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28895403/injectable-carbon-nanotube-functionalized-reverse-thermal-gel-promotes-cardiomyocytes-survival-and-maturation
#20
Brisa Peña, Susanna Bosi, Brian A Aguado, Daniele Borin, Nikki L Farnsworth, Evgenia Dobrinskikh, Teisha J Rowland, Valentina Martinelli, Mark Jeong, Matthew R G Taylor, Carlin S Long, Robin Shandas, Orfeo Sbaizero, Maurizio Prato, Kristi S Anseth, Daewon Park, Luisa Mestroni
The ability of the adult heart to regenerate cardiomyocytes (CMs) lost after injury is limited, generating interest in developing efficient cell-based transplantation therapies. Rigid carbon nanotubes (CNTs) scaffolds have been used to improve CMs viability, proliferation, and maturation, but they require undesirable invasive surgeries for implantation. To overcome this limitation, we developed an injectable reverse thermal gel (RTG) functionalized with CNTs (RTG-CNT) that transitions from a solution at room temperature to a three-dimensional (3D) gel-based matrix shortly after reaching body temperature...
September 20, 2017: ACS Applied Materials & Interfaces
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