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https://www.readbyqxmd.com/read/28636254/pirfenidone-reduces-subchondral-bone-loss-and-fibrosis-after-murine-knee-cartilage-injury
#1
Deva D Chan, Jun Li, Wei Luo, Dan N Predescu, Brian J Cole, Anna Plaas
Pirfenidone is an anti-inflammatory and anti-fibrotic drug that has shown efficacy in lung and kidney fibrosis. Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in a mouse model of cartilage injury, which results in chronic inflammation and joint-wide fibrosis in mice that lack hyaluronan synthase 1 (Has1(-/-) ) in comparison to wild-type. Femoral cartilage was surgically injured in wild-type and Has1(-/-) mice, and Pirfenidone was administered in food starting after 3 days...
June 21, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28635089/comparison-of-fall-related-traumatic-brain-injury-in-residential-aged-care-and-community-dwelling-older-people-a-population-based-study
#2
Lara A Harvey, Rebecca Mitchell, Henry Brodaty, Brian Draper, Jacqueline Ct Close
OBJECTIVE: To compare trends, causes, and outcomes of fall-related traumatic brain injury (TBI) between community-dwelling (CD) individuals and residential aged care facility (RACF) residents. METHODS: Hospitalisation and RACF administrative data for 6635 individuals aged ≥65 years admitted to all NSW hospitals for fall-related TBI from 2008-2009 to 2012-2013 were linked. RESULTS: Of the 6944 hospitalisations, 20.8% were for RACF residents...
June 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/28634220/tidal-changes-on-ct-and-progression-of-ards
#3
Maurizio Cereda, Yi Xin, Hooman Hamedani, Giacomo Bellani, Stephen Kadlecek, Justin Clapp, Luca Guerra, Natalie Meeder, Jennia Rajaei, Nicholas J Tustison, James C Gee, Brian P Kavanagh, Rahim R Rizi
BACKGROUND: Uncertain prediction of outcome in acute respiratory distress syndrome (ARDS) impedes individual patient management and clinical trial design. OBJECTIVES: To develop a radiological metric of injurious inflation derived from matched inspiratory and expiratory CT scans, calibrate it in a model of experimental lung injury, and test it in patients with ARDS. METHODS: 73 anaesthetised rats (acid aspiration model) were ventilated (protective or non-protective) for up to 4 hours to generate a spectrum of lung injury...
June 20, 2017: Thorax
https://www.readbyqxmd.com/read/28634002/acupressure-therapy-for-acute-ankle-sprains-a-randomized-clinical-trial
#4
Mingxing Zhao, Wei Gao, Long Zhang, Wei Huang, Sihua Zheng, Guanliang Wang, Brian Y Hong, Baoyong Tang
BACKGROUND: Ankle sprains occur frequently among young and active people, accounting for almost two million injuries per year. Previous reports suggest that acupressure therapy for acute ankle sprains may shorten the recovery time. OBJECTIVE: To evaluate whether acupressure therapy can improve ankle sprain recovery when compared to standard RICE (rest, ice, compression, and elevation) treatment. DESIGN: A randomized controlled trial was conducted...
June 17, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28633768/comparing-different-surgical-techniques-for-addressing-the-posterior-malleolus-in-supination-external-rotation-ankle-fractures-and-the-need-for-syndesmotic-screw-fixation
#5
Mengnai Li, Rachel C Collier, Brian W Hill, Nathaniel Slinkard, Thuan V Ly
Trimalleolar ankle fractures are unstable injuries with possible syndesmotic disruption. Recent data have described inherent morbidity associated with screw fixation of the syndesmosis, including the potential for malreduction, hardware irritation, and post-traumatic arthritis. The posterior malleolus is an important soft tissue attachment for the posterior inferior syndesmosis ligament. We hypothesized that fixation of a sizable posterior malleolar (PM) fracture in supination external rotation type IV (SER IV) ankle fractures would act to stabilize the syndesmosis and minimize or eliminate the need for trans-syndesmotic fixation...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28632657/role-of-computed-tomography-in-the-classification-of-pediatric-pelvic-fractures-revisited
#6
Melissa A Bent, William L Hennrikus, Johan E Latorre, Douglas G Armstrong, Brian Shaw, Kerwyn C Jones, Lee S Segal
OBJECTIVES: To determine the need for computerized tomography (CT) scans in the assessment of pediatric pelvic fractures. DESIGN: Retrospective Chart Review. SETTING: Level-1 Pediatric Trauma Center. PATIENTS/PARTICIPANTS: Thirty pediatric trauma patients with pelvic fractures who have obtained both a radiograph and CT scan. MAIN OUTCOME MEASUREMENTS: Fleiss Kappa coefficient to compare interreliability...
July 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28632581/multicenter-retrospective-study-of-noncompressible-torso-hemorrhage-anatomic-locations-of-bleeding-and-comparison-of-endovascular-versus-open-approach
#7
Ronald Chang, Erin E Fox, Thomas J Greene, Brian J Eastridge, Ramyar Gilani, Kevin K Chung, Stacia M DeSantis, Joseph J DuBose, Jeffrey S Tomasek, Gerald R Fortuna, Valerie G Sams, S Rob Todd, Jeanette M Podbielski, Charles E Wade, John B Holcomb
BACKGROUND: Rational development of technology for rapid control of noncompressible torso hemorrhage (NCTH) requires detailed understanding of what is bleeding. Our objectives were to describe the anatomic location of truncal bleeding in patients presenting with NCTH and compare endovascular (ENDO) management versus open (OPEN) management. METHODS: This is a retrospective study of adult trauma patients with NCTH admitted to four urban Level I trauma centers in the Houston and San Antonio metropolitan areas in 2008 to 2012...
July 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28628913/age-dependent-effects-of-alk5-inhibition-and-mechanism-of-neuroprotection-in-neonatal-hypoxic-ischemic-brain-injury
#8
Brian H Kim, Mariano Guardia Clausi, Michelle Frondelli, Israel C Nnah, Chaitali Saqcena, Radek Dobrowolski, Steven W Levison
Neonatal encephalopathy due to hypoxic-ischemic (HI) brain injury triggers a wave of neuroinflammatory events attributed to causing the progressive degeneration and functional deficits seen weeks after the initial insult. In a recent set of studies, we evaluated the therapeutic efficacy of a small molecule antagonist for ALK5 (activin-like kinase 5 ), TGF-β receptor in a rat model of moderate perinatal HI and found significant improvements in neurologic outcomes. Here, we have extended those studies to evaluate the efficacy of delayed TGF-β receptor antagonism on postnatal day (P) 6 and P9 HI rat pups with and without hypothermia...
June 20, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28628039/chrebp-refines-the-hepatic-response-to-fructose-to-protect-the-liver-from-injury
#9
Angela M Hall, Brian N Finck
Overconsumption of fructose and other sugars has been linked to nonalcoholic fatty liver disease (NAFLD); however, the sugar-associated effects that lead to disease are poorly defined. In this issue of the JCI, Zhang and colleagues show that the carbohydrate response element-binding protein (ChREBP) coordinates an adaptive response to a high-fructose diet in mice and that loss of this transcription factor leads to hepatic inflammation and early signs of fibrosis. Intriguingly, ChREBP-dependent effects were due to an exaggerated activation of the proapoptotic arms of the endoplasmic reticulum stress response that is probably secondary to inappropriate derepression of cholesterol biosynthesis...
June 19, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28619532/major-physical-health-conditions-and-risk-of-suicide
#10
Brian K Ahmedani, Edward L Peterson, Yong Hu, Rebecca C Rossom, Frances Lynch, Christine Y Lu, Beth E Waitzfelder, Ashli A Owen-Smith, Samuel Hubley, Deepak Prabhakar, L Keoki Williams, Nicole Zeld, Elizabeth Mutter, Arne Beck, Dennis Tolsma, Gregory E Simon
INTRODUCTION: Most individuals make healthcare visits before suicide, but many do not have a diagnosed mental health condition. This study seeks to investigate suicide risk among patients with a range of physical health conditions in a U.S. general population sample and whether risk persists after adjustment for mental health and substance use diagnoses. METHODS: This study included 2,674 individuals who died by suicide between 2000 and 2013 along with 267,400 controls matched on year and location in a case-control study conducted in 2016 across eight Mental Health Research Network healthcare systems...
June 7, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28616357/improvement-of-post-hypoxic-myoclonus-with-bilateral-pallidal-deep-brain-stimulation-a-case-report-and-review-of-the-literature
#11
Ritesh A Ramdhani, Steven J Frucht, Brian H Kopell
BACKGROUND: Post-hypoxic myoclonus (PHM) is a syndrome that occurs when a patient has suffered hypoxic brain injury. The myoclonus is usually multifocal and generalized, often stemming from both cortical and subcortical origins. In severe cases, pharmacological treatments with antiepileptic medications may not satisfactorily control the myoclonus. METHODS: We present a case of a 23-year-old male with chronic medication refractory PHM following a cardiopulmonary arrest related to an asthmatic attack who improved with bilateral globus pallidus internus (GPi) deep brain stimulation (DBS)...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28616015/correction-the-translational-importance-of-establishing-biomarkers-of-human-spinal-cord-injury
#12
Sanam Salimi Elizei, Brian K Kwon
[This corrects the article on p. 385 in vol. 12, PMID: 28469645.].
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28612890/technology-in-rehabilitation-comparing-personalised-and-global-classification-methodologies-in-evaluating-the-squat-exercise-with-wearable-imus
#13
Martin A O'Reilly, Darragh Whelan, Tomás E Ward, Eamonn Delahunt, Brian Caulfield
BACKGROUND: The barbell squat is a popularly used lower limb rehabilitation exercise. It is also an integral exercise in injury risk screening protocols. To date athlete/patient technique has been assessed using expensive laboratory equipment or subjective clinical judgement; both of which are not without shortcomings. Inertial measurement units (IMUs) may offer a low cost solution for the objective evaluation of athlete/patient technique. However, it is not yet known if global classification techniques are effective in identifying naturally occurring, minor deviations in barbell squat technique...
June 14, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28612260/utility-of-spherical-human-liver-microtissues-for-prediction-of-clinical-drug-induced-liver-injury
#14
William R Proctor, Alison J Foster, Jennifer Vogt, Claire Summers, Brian Middleton, Mark A Pilling, Daniel Shienson, Monika Kijanska, Simon Ströbel, Jens M Kelm, Paul Morgan, Simon Messner, Dominic Williams
Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in drug discovery. Three-dimensional (3D) spheroid hepatic cultures have emerged as promising tools to assess mechanisms of hepatotoxicity, as they demonstrate enhanced liver phenotype, metabolic activity, and stability in culture not attainable with conventional two-dimensional hepatic models...
June 13, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28602586/fungal-periapical-abscess-and-the-burn-patient-a-report-of-two-cases-of-an-unreported-source-for-systemic-infection
#15
Stephen Serio, Brian Burgess, David Voigt
Fungal infections in the intensive care unit are becoming a more common occurrence, especially in the care of the burn patient. Fungal infections in the critically burned patient, who by nature have a heightened inflammatory state and impaired immune response, have been found to carry a profound degree of morbidity and mortality. We present our experience in the care of severe thermal injuries; a series of patients with endodontic fungal infection which, as we found, pose a significant risk for the development of systemic infection and sepsis...
June 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28601588/identifying-high-risk-loading-conditions-for-in-season-injury-in-elite-australian-football-players
#16
Jordan Stares, Brian Dawson, Peter Peeling, Jarryd Heasman, Brent Rogalski, Michael Drew, Marcus Colby, Gregory Dupont, Leanne Lester
OBJECTIVES: To examine different timeframes for calculating acute to chronic workload ratio (ACWR) and whether this variable is associated with intrinsic injury risk in elite Australian football players. DESIGN: Prospective cohort study. METHODS: Internal (session rating of perceived exertion: sRPE) and external (GPS distance and sprint distance) workload and injury data were collected from 70 players from one AFL club over 4 seasons. Various acute (1-2 weeks) and chronic (3-8 weeks) timeframes were used to calculate ACWRs: these and chronic load categories were then analysed to determine the injury risk in the subsequent month...
May 25, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28601205/remote-damage-control-resuscitation-in-austere-environments
#17
REVIEW
Ronald Chang, Brian J Eastridge, John B Holcomb
Hemorrhage is the leading cause of preventable military and civilian trauma death. Damage control resuscitation with concomitant mechanical hemorrhage control has become the preferred in-hospital treatment of hemorrhagic shock. In particular, plasma-based resuscitation with decreased volumes of crystalloids and artificial colloids as part of damage control resuscitation has improved outcomes in the military and civilian sectors. However, translation of these principles and techniques to the prehospital, remote, and austere environments, known as remote damage control resuscitation, is challenging given the resource limitations in these settings...
June 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28599608/a-brain-electrical-activity-eeg-based-biomarker-of-functional-impairment-in-traumatic-head-injury-a-multisite-validation-trial
#18
Daniel Hanley, Leslie S Prichep, Neeraj Badjatia, Jeff Bazarian, RIchard P Chiacchierini, Kenneth C Curley, John S Garrett, Elizabeth B Jones, Rosanne Naunheim, Brian J O'Neil, John O'Neill, Wright David, J Stephen Huff
The potential clinical utility of a novel quantitative EEG-based Brain Function Index (BFI) as a measure of the presence and severity of functional brain injury was studied as part of an independent prospective validation trial. The BFI was derived using EEG features associated with functional brain impairment reflecting current consensus on the physiology of concussive injury. 720 adult patients (18-85 years) evaluated within 72 hours of sustaining a closed head injury were enrolled at 11 US Emergency Departments...
June 9, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28599602/spinal-cord-injury-causes-systolic-dysfunction-and-cardiomyocyte-atrophy
#19
Jordan W Squair, Kathryn M DeVeau, Kathryn A Harman, Malihe-Sadat Poormasjedi-Meibod, Brian Hayes, Jie Liu, David S K Magnuson, Andrei V Krassioukov, Christopher R West
Individuals with spinal cord injury (SCI) have been shown to exhibit systolic, and to a lesser extent, diastolic cardiac dysfunction. However, previous reports of cardiac dysfunction in this population are confounded by the changing loading conditions after SCI and as such, whether cardiac dysfunction per se is present is still unknown. Therefore, our aim was to establish if load-independent cardiac dysfunction is present after SCI, to understand the functional cardiac response to SCI, and to explore the changes within the cellular milieu of the myocardium...
June 9, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28599231/open-and-contaminated-pediatric-pelvic-ring-injury-case-report-fixation-without-metal
#20
Brian R Dilworth, John T Riehl
INTRODUCTION: Pelvic fractures are relatively uncommon in children, accounting for 0.3-7.5% of all pediatric injuries (Gänsslen et al., 2013; Ismail et al., 1996; Peltier, 1965; Galano et al., 2005; Spiguel et al., 2006). This case report describes a pediatric open pelvic injury caused by a crush mechanism between a car and guardrail. CASE: A 13year old male presented with an open APC 3 pelvic injury after being pinned between a car and guardrail. His definitive treatment included bilateral SI screw placement, as well as a less invasive method for anterior pelvic ring disruption (Internal Brace suture anchor dynamic fixation)...
2017: International Journal of Surgery Case Reports
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