keyword
https://read.qxmd.com/read/38534474/engineered-dual-antioxidant-enzyme-complexes-targeting-icam-1-on-brain-endothelium-reduce-brain-injury-associated-neuroinflammation
#1
JOURNAL ARTICLE
Brian M Leonard, Vladimir V Shuvaev, Trent A Bullock, Kalpani N Udeni Galpayage Dona, Vladimir R Muzykantov, Allison M Andrews, Servio H Ramirez
The neuroinflammatory cascade triggered by traumatic brain injury (TBI) represents a clinically important point for therapeutic intervention. Neuroinflammation generates oxidative stress in the form of high-energy reactive oxygen and nitrogen species, which are key mediators of TBI pathology. The role of the blood-brain barrier (BBB) is essential for proper neuronal function and is vulnerable to oxidative stress. Results herein explore the notion that attenuating oxidative stress at the vasculature after TBI may result in improved BBB integrity and neuroprotection...
February 21, 2024: Bioengineering
https://read.qxmd.com/read/38534337/phosphorylations-and-acetylations-of-cytochrome-c-control-mitochondrial-respiration-mitochondrial-membrane-potential-energy-ros-and-apoptosis
#2
REVIEW
Paul T Morse, Tasnim Arroum, Junmei Wan, Lucynda Pham, Asmita Vaishnav, Jamie Bell, Lauren Pavelich, Moh H Malek, Thomas H Sanderson, Brian F P Edwards, Maik Hüttemann
Cytochrome c (Cyt c ) has both life-sustaining and cellular death-related functions, depending on subcellular localization. Within mitochondria, Cyt c acts as a single electron carrier as part of the electron transport chain (ETC). When released into the cytosol after cellular insult, Cyt c triggers the assembly of the apoptosome, committing the cell to intrinsic apoptosis. Due to these dual natures, Cyt c requires strong regulation by the cell, including post-translational modifications, such as phosphorylation and acetylation...
March 12, 2024: Cells
https://read.qxmd.com/read/38532264/the-effect-of-a-hip-fragility-pathway-on-outcomes-of-ground-level-falls-in-the-elderly
#3
JOURNAL ARTICLE
Jack Nadaud, Eric Heidel, Brian Daley, Catherine McKnight
Fragility hip fractures result from low energy mechanisms and are associated with morbidity and mortality, especially in the elderly. We examined outcomes 2 years before and after implementation of a fragility fracture program. The pathway involves emergency department clearance and admission by a medical service with orthopedic consultation. Demographics include age, gender, fracture location, injury severity score (ISS), and ASA. Outcomes include DVT/PE, mortality, disposition, non-operative rate, ICU admission, time to surgery (TTS), length of stay (LOS), and admission service...
March 26, 2024: American Surgeon
https://read.qxmd.com/read/38531344/treating-lateral-epicondylopathy-with-dry-needling-and-exercise-a-case-series
#4
JOURNAL ARTICLE
Brian V Hortz, Sue Falsone
CONTEXT: Lateral epicondylopathy (LE) is a common overuse injury affecting elbow, wrist, and hand function. It is characterized by weakness and pain in the muscles and tendons of the forearm responsible for the extension of your wrist and fingers. Trigger point dry needling is a technique reported to be beneficial in managing pain and dysfunction after LE diagnosis. LE is also commonly treated with conservative treatment, such as joint and soft tissue mobilization, self-care home programs, and anti-inflammatory use...
March 26, 2024: Journal of Sport Rehabilitation
https://read.qxmd.com/read/38531329/treatment-and-long-term-safety-outcomes-of-peptide-receptor-radionuclide-therapy-for-metastatic-neuroendocrine-tumours-an-asian-experience
#5
JOURNAL ARTICLE
Wei Ying Tham, Hian Liang Huang, David Wai Meng Tai, John C Allen, Jacqueline S G Hwang, Lih Ming Loh, Brian K P Goh, Simon Y K Ong, Peng Chin Kek, Damien M Y Tan, David C E Ng, Kelvin S H Loke
Peptide-receptor radionuclide therapy (PRRT) is a targeted molecular therapy used to treat neuroendocrine tumours (NET). It has been shown to be effective and well-tolerated in patients with metastatic neuroendocrine tumours in several centres in United States (US), Europe and Australia. Tolerability and efficacy data emerging from Asian centres remain few. Epidemiological evidence suggests that there are differences in neuroendocrine neoplasms between the population groups. We aim to describe the treatment and safety outcomes of PRRT in the Asian population...
March 26, 2024: Neuroendocrinology
https://read.qxmd.com/read/38529582/embolization-of-a-pseudoaneurysm-of-the-innominate-artery-with-a-woven-endobridge-web-device
#6
JOURNAL ARTICLE
Gil Zur, Areej Fageeh, Ange Diouf, Stacey Charette, Brigitte Charbonneau, Leila Sellami, Marlise Dos Santos, Howard Lesiuk, Brian Drake, Robert Fahed
The Woven EndoBridge (WEB) is an intra-aneurysmal flow disruptor designed for the treatment of broad-based arterial aneurysms with a high safety and effectiveness profile.1, 2 It does not require concomitant antiplatelet therapy compared to other devices such as flow diverters or intracranial stents. Innominate artery pseudoaneurysms are a rare consequence of blunt traumatic injury, infection, or atherosclerotic disease.3, 4 We describe the case of an innominate artery pseudoaneurysm successfully treated with a WEB SL device instead of stenting, therefore alleviating the need for dual antiplatelet therapy...
March 26, 2024: Interventional Neuroradiology
https://read.qxmd.com/read/38529316/impact-of-covid-status-and-blood-group-on-complications-in-patients-in-hemorrhagic-shock
#7
JOURNAL ARTICLE
Jason Bradley Brill, Krislynn M Mueck, Madeline E Cotton, Brian Tang, Mariela Sandoval, Lillian S Kao, Bryan A Cotton
OBJECTIVE: Among critically injured patients of various blood groups, we sought to compare survival and complication rates between COVID-19-positive and COVID-19-negative cohorts. BACKGROUND: SARS-CoV-2 infections have been shown to cause endothelial injury and dysfunctional coagulation. We hypothesized that, among patients with trauma in hemorrhagic shock, COVID-19-positive status would be associated with increased mortality and inpatient complications. As a secondary hypothesis, we suspected group O patients with COVID-19 would experience fewer complications than non-group O patients with COVID-19...
2024: Trauma Surgery & Acute Care Open
https://read.qxmd.com/read/38526931/interventions-to-optimize-spinal-cord-perfusion-in-patients-with-acute-traumatic-spinal-cord-injury-an-updated-systematic-review
#8
JOURNAL ARTICLE
Nathan Evaniew, Benjamin Davies, Farzin Farahbakhsh, Michael G Fehlings, Mario Ganau, Daniel Graves, James D Guest, Radha Korupolu, Allan R Martin, Stephen L McKenna, Lindsay A Tetreault, Aditya Vedantam, Erika D Brodt, Andrea C Skelly, Brian K Kwon
STUDY DESIGN: Systematic review update. OBJECTIVES: Interventions that aim to optimize spinal cord perfusion are thought to play an important role in minimizing secondary ischemic damage and improving outcomes in patients with acute traumatic spinal cord injuries (SCIs). However, exactly how to optimize spinal cord perfusion and enhance neurologic recovery remains controversial. We performed an update of a recent systematic review (Evaniew et al, J. Neurotrauma 2020) to evaluate the effects of Mean Arterial Pressure (MAP) support or Spinal Cord Perfusion Pressure (SCPP) support on neurological recovery and rates of adverse events among patients with acute traumatic SCI...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526930/ao-spine-praxis-clinical-practice-guidelines-for-the-management-of-acute-spinal-cord-injury-an-introduction-to-a-focus-issue
#9
JOURNAL ARTICLE
Brian K Kwon, Lindsay A Tetreault, Nathan Evaniew, Andrea C Skelly, Michael G Fehlings
STUDY DESIGN: Narrative overview and summary. OBJECTIVES: The objective of this introductory manuscript is to provide an overview of the effort that was undertaken to establish clinical practice guidelines for a number of important topics in spinal cord injury (SCI). These topics included: 1. The role and timing of surgical decompression after acute traumatic SCI; 2. The hemodynamic management of acute traumatic SCI; and 3. The definition, diagnosis, and management of intra-operative SCI...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526929/timing-of-decompressive-surgery-in-patients-with-acute-spinal-cord-injury-systematic-review-update
#10
JOURNAL ARTICLE
Michael G Fehlings, Laureen D Hachem, Lindsay A Tetreault, Andrea C Skelly, Joseph R Dettori, Erika D Brodt, Shay Stabler-Morris, Britt J Redick, Nathan Evaniew, Allan R Martin, Benjamin Davies, Farzin Farahbakhsh, James D Guest, Daniel Graves, Radha Korupolu, Stephen L McKenna, Brian K Kwon
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: Surgical decompression is a cornerstone in the management of patients with traumatic spinal cord injury (SCI); however, the influence of the timing of surgery on neurological recovery after acute SCI remains controversial. This systematic review aims to summarize current evidence on the effectiveness, safety, and cost-effectiveness of early (≤24 hours) or late (>24 hours) surgery in patients with acute traumatic SCI for all levels of the spine...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526928/an-overview-of-the-methodology-used-to-develop-clinical-practice-guidelines-for-the-management-of-acute-and-intraoperative-spinal-cord-injury
#11
JOURNAL ARTICLE
Lindsay A Tetreault, Andrea C Skelly, Mohammed Ali Alvi, Brian K Kwon, Nathan Evaniew, Michael G Fehlings
STUDY DESIGN: An overview of the methods used to develop clinical practice guidelines (CPGs). OBJECTIVES: Acute spinal cord injury (SCI) and intraoperative SCI (ISCI) can have devastating physical and psychological consequences for patients and their families. To date, there are several studies that have discussed the diagnostic and management strategies for both SCI and ISCI. CPGs in SCI help to distill and translate the current evidence into actionable recommendations, standardize care across centers, optimize patient outcomes, and reduce costs and unnecessary interventions...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526927/definition-frequency-and-risk-factors-for-intra-operative-spinal-cord-injury-a-knowledge-synthesis
#12
JOURNAL ARTICLE
Michael G Fehlings, Ayesha Quddusi, Andrea C Skelly, Erika D Brodt, Ali Moghaddamjou, Anahita Malvea, Nader Hejrati, Nisaharan Srikandarajah, Mohammed Ali Alvi, Shay Stabler-Morris, Joseph R Dettori, Lindsay A Tetreault, Nathan Evaniew, Brian K Kwon
STUDY DESIGN: Mixed-methods approach. OBJECTIVES: Intra-operative spinal cord injury (ISCI) is a devastating complication of spinal surgery. Presently, a uniform definition for ISCI does not exist. Consequently, the reported frequency of ISCI and important risk factors vary in the existing literature. To address these gaps in knowledge, a mixed-methods knowledge synthesis was undertaken. METHODS: A scoping review was conducted to review the definitions used for ISCI and to ascertain the frequency of ISCI...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526926/the-2023-ao-spine-praxis-guidelines-in-acute-spinal-cord-injury-what-have-we-learned-what-are-the-critical-knowledge-gaps-and-barriers-to-implementation
#13
JOURNAL ARTICLE
Michael G Fehlings, Ali Moghaddamjou, Nathan Evaniew, Lindsay A Tetreault, Mohammed Ali Alvi, Andrea C Skelly, Brian K Kwon
STUDY DESIGN: Narrative summary of the 2023 AO Spine-Praxis clinical practice guidelines for management in acute spinal cord injury (SCI). OBJECTIVES: The objective of this article is to summarize the key findings of the clinical practice guidelines for the optimal management of traumatic and intraoperative SCI (ISCI). This article will also highlight potential knowledge translation opportunities for each recommendation and discuss important knowledge gaps and areas of future research...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526925/prevention-diagnosis-and-management-of-intraoperative-spinal-cord-injury-in-the-setting-of-spine-surgery-a-proposed-care-pathway
#14
JOURNAL ARTICLE
Nisaharan Srikandarajah, Nader Hejrati, Mohammed Ali Alvi, Ayesha Quddusi, Lindsay A Tetreault, Nathan Evaniew, Andrea C Skelly, Sam Douglas, Vafa Rahimi-Movaghar, Paul M Arnold, Steven Kirshblum, Brian K Kwon, Michael G Fehlings
STUDY DESIGN: This study is a mixed methods approach. OBJECTIVES: Intraoperative spinal cord injury (ISCI) is a challenging complication in spine surgery. Intra-operative neuromonitoring (IONM) has been developed to detect changes in neural function. We report on the first multidisciplinary, international effort through AO Spine and the Praxis Spinal Cord Institute to develop a comprehensive guideline and care pathway for the prevention, diagnosis, and management of ISCI...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526924/the-management-of-intraoperative-spinal-cord-injury-a-scoping-review
#15
JOURNAL ARTICLE
Nader Hejrati, Nisaharan Srikandarajah, Mohammed Ali Alvi, Ayesha Quddusi, Lindsay A Tetreault, James D Guest, Rex A W Marco, Steven Kirshblum, Allan R Martin, Samuel Strantzas, Paul M Arnold, Saumyajit Basu, Nathan Evaniew, Brian K Kwon, Andrea C Skelly, Michael G Fehlings
STUDY DESIGN: Scoping Review. OBJECTIVE: To review the literature and summarize information on checklists and algorithms for responding to intraoperative neuromonitoring (IONM) alerts and management of intraoperative spinal cord injuries (ISCIs). METHODS: MEDLINE® was searched from inception through January 26, 2022 as were sources of grey literature. We attempted to obtain guidelines and/or consensus statements from the following sources: American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM), American Academy of Neurology (AAN), American Clinical Neurophysiology Society, NASS (North American Spine Society), and other spine surgery organizations...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526923/a-clinical-practice-guideline-for-the-management-of-patients-with-acute-spinal-cord-injury-recommendations-on-hemodynamic-management
#16
JOURNAL ARTICLE
Brian K Kwon, Lindsay A Tetreault, Allan R Martin, Paul M Arnold, Rex A W Marco, Virginia F J Newcombe, Carl M Zipser, Stephen L McKenna, Radha Korupolu, Chris J Neal, Rajiv Saigal, Nina E Glass, Sam Douglas, Mario Ganau, Vafa Rahimi-Movaghar, James S Harrop, Bizhan Aarabi, Jefferson R Wilson, Nathan Evaniew, Andrea C Skelly, Michael G Fehlings
STUDY DESIGN: Clinical practice guideline development following the GRADE process. OBJECTIVES: Hemodynamic management is one of the only available treatment options that likely improves neurologic outcomes in patients with acute traumatic spinal cord injury (SCI). Augmenting mean arterial pressure (MAP) aims to improve blood perfusion and oxygen delivery to the injured spinal cord in order to minimize secondary ischemic damage to neural tissue. The objective of this guideline was to update the 2013 AANS/CNS recommendations on the hemodynamic management of patients with acute traumatic SCI, acknowledging that much has been published in this area since its publication...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526922/an-update-of-a-clinical-practice-guideline-for-the-management-of-patients-with-acute-spinal-cord-injury-recommendations-on-the-role-and-timing-of-decompressive-surgery
#17
JOURNAL ARTICLE
Michael G Fehlings, Lindsay A Tetreault, Laureen Hachem, Nathan Evaniew, Mario Ganau, Stephen L McKenna, Chris J Neal, Narihito Nagoshi, Vafa Rahimi-Movaghar, Bizhan Aarabi, Christoph P Hofstetter, Valerie Ter Wengel, Hiroaki Nakashima, Allan R Martin, Steven Kirshblum, Ricardo Rodrigues Pinto, Rex A W Marco, Jefferson R Wilson, David E Kahn, Virginia F J Newcombe, Carl M Zipser, Sam Douglas, Shekar N Kurpad, Yi Lu, Rajiv Saigal, Uzma Samadani, Paul M Arnold, Gregory W J Hawryluk, Andrea C Skelly, Brian K Kwon
STUDY DESIGN: Clinical practice guideline development. OBJECTIVES: Acute spinal cord injury (SCI) can result in devastating motor, sensory, and autonomic impairment; loss of independence; and reduced quality of life. Preclinical evidence suggests that early decompression of the spinal cord may help to limit secondary injury, reduce damage to the neural tissue, and improve functional outcomes. Emerging evidence indicates that "early" surgical decompression completed within 24 hours of injury also improves neurological recovery in patients with acute SCI...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526921/a-clinical-practice-guideline-for-prevention-diagnosis-and-management-of-intraoperative-spinal-cord-injury-recommendations-for-use-of-intraoperative-neuromonitoring-and-for-the-use-of-preoperative-and-intraoperative-protocols-for-patients-undergoing-spine-surgery
#18
JOURNAL ARTICLE
Michael G Fehlings, Mohammed Ali Alvi, Nathan Evaniew, Lindsay A Tetreault, Allan R Martin, Stephen L McKenna, Vafa Rahimi-Movaghar, Yoon Ha, Steven Kirshblum, Nader Hejrati, Nisaharan Srikandarajah, Ayesha Quddusi, Ali Moghaddamjou, Anahita Malvea, Ricardo Rodrigues Pinto, Rex A W Marco, Virginia F J Newcombe, Saumayajit Basu, Samuel Strantzas, Carl M Zipser, Sam Douglas, Ilya Laufer, Dean Chou, Rajiv Saigal, Paul M Arnold, Gregory W J Hawryluk, Andrea C Skelly, Brian K Kwon
STUDY DESIGN: Development of a clinical practice guideline following the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) process. OBJECTIVE: The objectives of this study were to develop guidelines that outline the utility of intraoperative neuromonitoring (IONM) to detect intraoperative spinal cord injury (ISCI) among patients undergoing spine surgery, to define a subset of patients undergoing spine surgery at higher risk for ISCI and to develop protocols to prevent, diagnose, and manage ISCI...
March 2024: Global Spine Journal
https://read.qxmd.com/read/38526215/characterization-of-individual-bile-acids-in-vivo-utilizing-a-novel-low-bile-acid-mouse-model
#19
JOURNAL ARTICLE
Rulaiha Taylor, Zhenning Yang, Zakiyah Henry, Gina Capece, Vik Meadows, Katherine Otersen, Veronia Basaly, Anisha Bhattacharya, Stephanie Mera, Peihong Zhou, Laurie Joseph, Ill Yang, Anita Brinker, Brian Buckley, Bo Kong, Grace L Guo
Bile acids (BAs) are signaling molecules synthesized in the liver initially by CYP7A1 and CYP27A1 in the classical and alternative pathways, respectively. BAs are essential for cholesterol clearance, intestinal absorption of lipids, and endogenous modulators of farnesoid x receptor (FXR). FXR is critical in maintaining BA homeostasis and gut-liver crosstalk. Complex reactions in vivo and the lack of suitable animal models impede our understanding of the functions of individual BAs. In this study, we characterized the in vivo effects of three-day feeding of cholic acid (CA), deoxycholic acid (DCA), or ursodeoxycholic acid (UDCA) at physiological/non-hepatotoxic concentrations in a novel low-BA mouse model (Cyp7a1  -/-/Cyp27a1  -/-, DKO)...
March 25, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38523239/a-two-year-comparison-of-reverse-total-shoulder-arthroplasty-mini-humeral-tray-and-augmented-mini-glenoid-baseplate-implants-vs-standard-implants
#20
JOURNAL ARTICLE
Ryan Krupp, Christopher O'Grady, Brian Werner, J Michael Wiater, John Nyland, Thomas Duquin
BACKGROUND: Patients who undergo reverse total shoulder arthroplasty (RTSA) are getting younger with greater function expectations. This retrospective, longitudinal study of prospectively collected data compared perceived shoulder function and strength, active shoulder mobility, radiographic evidence of scapular notching, and implant survival over the initial 2-years post-RTSA among patient groups who received either standard central fixation point liner and glenoid baseplate implants, or lower size profile mini-humeral tray with offset trunnion options and mini-augmented glenoid baseplate implants...
March 25, 2024: Archives of Orthopaedic and Trauma Surgery
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