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JOURNAL ARTICLE
Chuang Wang, Lu-Yuan Qin, Dong-Mei Li, Li-Gang Hu, Jin-Juan Xue, Xin-Ping Zhai, Qiang Wang, Lei Guo, Li Tang, Jian-Wei Xie
This work aims to rapidly detect toxic alkaloids in traditional Chinese medicines (TCM) using laser desorption ionization mass spectrometry (LDI-MS). We systematically investigated twelve nanomaterials (NMs) as matrices and found that MoS2 and defect-rich-WO3 (D-WO3 ) were the best NMs for alkaloid detection. MoS2 and D-WO3 can be used directly as matrices dipped onto conventional ground steel target plates. Additionally, they can be conveniently fabricated as three-dimensional (3D) NM plates, where the MoS2 or D-WO3 NM is doped into resin and formed using a 3D printing process...
October 18, 2023: Analytical and Bioanalytical Chemistry
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JOURNAL ARTICLE
[Research progress in clinical application and pharmacological effect of Yiyi Fuzi Baijiang Powder].
Liu-Yi Wei, Er-Wei Hao, Xiao-Tao Hou, Liu-Zhi Wei, Zhe Qin, Xiao Yang, Qian Xiao, Shi-du Yan, Jia-Gang Deng
Yiyi Fuzi Baijiang Powder(YFBP), originating from Synopsis of the Golden Chamber, is a classic prescription composed of Coicis Semen, Aconiti Lateralis Radix Praeparata, and Patriniae Herba for the treatment of abscesses and pus discharge. This article presented a systematic analysis of the clinical application of YFBP, including the indicated diseases, the number of cases, efficacy, dosage, administration methods, and compatibility with other drugs. The analysis reveals that YFBP has a wide range of clinical applications...
September 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#23
JOURNAL ARTICLE
Liting Zhou, Ru Jia, Wanting Zeng, Qian Cai, Yang Qu
Ischemic stroke is a common type of stroke, but effective treatment methods are still imperfect and new effective therapies need to be explored. Radix Aconiti Coreani and Rhizoma Typhonii used as Baifuzi in the treatment of stroke or symptoms associated with stroke have been recorded in ancient Chinese books and are widely used. Modern pharmacological studies have demonstrated that both of them have antioxidant and anti-inflammatory effects. The purpose of this study is to investigate whether Radix Aconiti Coreani and Rhizoma Typhonii have therapeutical effects on gerbils with ischemic stroke, to investigate their potential mechanisms of action, and to provide a reference for rational clinical application by comparing the differences between them...
September 12, 2023: ACS Chemical Neuroscience
#24
JOURNAL ARTICLE
Wei Peng, Xiao Wang, Shu Fu, Ming-Quan Wu, Chao-Mei Fu, He Tu
This study aims to explore the core connotation of the compatibility of Aconiti Lateralis Radix Praeparata(Fuzi)-Glycyrrhizae Radix et Rhizoma(Gancao) herb pair under physiological and pathological conditions. The biochemical indicators of serum/myocardial tissue, pathological changes of the myocardial tissue, and serum metabolic profiles of normal rats and heart failure model rats treated with Fuzi Decoction and Fuzi Gancao Decoction were determined. Network pharmacology and metabolomics were employed to establish the metabolite-target-pathway network for Glycyrrhizae Radix et Rhizoma in enhancing the efficacy and reducing the toxicity of Aconiti Lateralis Radix Praeparata, Western blotting was employed to verify the representative pathways in the network...
July 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#25
JOURNAL ARTICLE
Tal Bechor Ariel, Ben Ariel, Yuni Lahav, Moshe Yana, Michael Ben-Acon, Nechama Sharon
BACKGROUND: Infants younger than 6 months of age are not eligible for coronavirus disease 2019 (COVID-19) vaccinations. Maternal variables during pregnancy and the postnatal period may affect the clinical and laboratory course of COVID-19 positive infants. OBJECTIVES: To assess the clinical manifestation and laboratory differences in infants with three maternal variables: breastfeeding, vaccinated, and co-illness. METHODS: We conducted a single-center retrospective cohort study of positive COVID-19 infants with three subgroups of maternal variables...
June 2023: Israel Medical Association Journal: IMAJ
#26
JOURNAL ARTICLE
Yuqing Chen, Lei Feng, Yanxi Han, Zihong Zhao, Zhenli Diao, Tao Huang, Yu Ma, Wanyu Feng, Jing Li, Ziqiang Li, Cong Liu, Lu Chang, Jinming Li, Rui Zhang
OBJECTIVES: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen detection is an indispensable tool for epidemic surveillance in the post-pandemic era. Faced with irregular performance, a comprehensive external quality assessment (EQA) scheme was conducted by the National Center for Clinical Laboratories (NCCL) to evaluate the analytical performance and status of SARS-CoV-2 antigen tests. METHODS: The EQA panel included ten lyophilized samples containing serial 5-fold dilutions of inactivated SARS-CoV-2-positive supernatants of the Omicron BA...
June 29, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
#27
JOURNAL ARTICLE
Chu-Jun Li, Rong-Rong Zhai, Xiao-Yu Zhu, Zi-Fan Guo, Hua Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional herbal pair Ginseng Radix et Rhizoma (roots and rhizomes of Panax ginseng C.A. Mey, Renshen in Chinese) and Aconiti Lateralis Radix Praeparata (lateral roots of Aconitum carmichaelii Debeaux, Fuzi in Chinese), composition of two traditional Chinese medicinal herbs, has been widely used in traditional Chinese medicine formula, in which Shenfu decoction has been used clinically in China for the treatment of heart failure at present. AIM OF THE STUDY: Although the ginsenosides and aconite alkaloids have been proven as the essential bioactive components in Renshen-Fuzi herbal pair, the exact composition of effective components to combat heart failure are still unclear...
June 21, 2023: Journal of Ethnopharmacology
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JOURNAL ARTICLE
Brad S Karon, Leslie J Donato, Ann M Moyer, Amy M Wockenfus, Brandon R Kelley, Ramanath Majumdar, Benjamin R Kipp, Joseph D Yao
BACKGROUND: Analytical sensitivity of 2 rapid antigen tests was evaluated for detection of presumed SARS-CoV-2 Omicron variants and earlier variants of concern. METHODS: A total of 152 SARS-CoV-2 RNA positive samples (N and ORF1ab positive but S gene negative) were tested for SARS-CoV-2 antigen by ACON lateral flow and LumiraDx fluorescence immunoassays. Sensitivity within 3 viral load ranges was compared among these 152 samples and 194 similarly characterized samples collected prior to the circulation of the Delta variant (pre-Delta)...
May 3, 2023: Diagnostic Microbiology and Infectious Disease
#29
JOURNAL ARTICLE
Wangmin Hu, Junling Hou, Wenjing Liu, Xuan Gu, Yulei Yang, Hongcai Shang, Mei Zhang
The automation of traditional Chinese medicine (TCM) pharmaceuticals has driven the development of process analysis from offline to online. Most of common online process analytical technologies are based on spectroscopy, making the identification and quantification of specific ingredients still a challenge. Herein, we developed a quality control (QC) system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry (mini-MS). It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time...
May 2023: Journal of Pharmaceutical Analysis
#30
Tal Bechor Ariel, Ben Ariel, Michael Ben-Acon, Nechama Sharon
Description of three cases of 4-7-year-old male children presenting with a seizure without a prior history of epilepsy, 2-4 weeks after recovering from COVID-19. All three children were admitted to the pediatric department at Laniado Hospital in Netanya, Israel, and presented with seizures without fever. We found common characteristics among the children that can imply a predisposition for neurological complications of Covid-19.
2023: Epilepsy & behavior reports
#31
JOURNAL ARTICLE
Xing-Jiang Xiong
Zhenwu Decoction is recorded in Treatise on Febrile Diseases by an outstanding physician ZHANG Zhong-jing in the Han dynasty. With effect of warming yang, transforming Qi, and promoting urination, Zhenwu Decoction is mainly used to treat edema due to yang deficiency. The studies of the severe and critical cases and the pathophysiological mechanisms have demonstrated that the record of Zhenwu Decoction in Treatise on Febrile Diseases describes the clinical symptoms and therapeutic regimen of acute heart failure...
May 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#32
RANDOMIZED CONTROLLED TRIAL
Sungha Kim, Muhack Yang, Boncho Ku, Eunhye Cha, Wookcheol Seo, Ilhong Son, Hyungwon Kang, Dongwoung Kim, Bongkeun Song, Chang-Sop Yang, Sungchul Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder characterized by progressive paralysis of voluntary muscles. Mecasin, the extract of modified jakyakgamchobuja-tang-a herbal preparation comprising of Radix Paeoniae Alba, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Gastrodiae, Radix Polygalae, Curcuma Root, Fructus Chaenomelis, and Rhizoma Atractylodis Japonicae-shows neuroprotective and anti-neuroinflammatory effects and alleviates the symptoms in patients with ALS...
October 28, 2023: Journal of Ethnopharmacology
#33
JOURNAL ARTICLE
He Gao, Zhenqiang Li, Chuanjing Cheng, Jing Cui, Jiamin Peng, Xiaoying Wang, Man Zhang, Yuanyuan Hou, Gang Bai
Radix aconiti carmichaeli is a widely used traditional Chinese medicine that has been found to be effective in treating cardiovascular diseases and metabolic disorders. Patients with these diseases often experience a heat generation disorder, which is characterized by chilliness and can worsen the progression of the disease. This study established an in vitro screening model combining the examination of cellular mitochondrial membrane potential and mitochondrial temperature to screen drugs with thermogenic activity...
May 6, 2023: International Journal of Molecular Sciences
#34
JOURNAL ARTICLE
Xiaoyan Tan, Qingxiu He, Zhaoqing Pei, Yue Liu, Zige Feng, Congying Li, Ce Tang, Yi Zhang
Radix Aconiti, also known as Tie-bang-chui (TBC), Pang-a-na-bao, and Bang-na, is a typical aconitum Tibetan medicine and a perennial herb of the genus Aconitum pendulum Busch. and A. flavum Hand. -Mazz. dry roots. It has high toxicity and remarkable efficacy; as such, it is a typical "highly toxic and effective" drug that needs be processed and used. Processing methods of this Tibetan medicine include non-heating of highland barley wine (HBW) and fructus chebulae soup (FCS). This work aimed to understand differences in chemical composition between non-heat processed products and raw TBC...
2023: Frontiers in Pharmacology
#35
JOURNAL ARTICLE
Hongxing Peng, Huiming Xu, Zongmei Gao, Zhiyan Zhou, Xingguo Tian, Qianting Deng, Huijun He, Chunlong Xian
INTRODUCTION: Crop pests have a great impact on the quality and yield of crops. The use of deep learning for the identification of crop pests is important for crop precise management. METHODS: To address the lack of data set and poor classification accuracy in current pest research, a large-scale pest data set named HQIP102 is built and the pest identification model named MADN is proposed. There are some problems with the IP102 large crop pest dataset, such as some pest categories are wrong and pest subjects are missing from the images...
2023: Frontiers in Plant Science
#36
JOURNAL ARTICLE
Qi Hu, Yu Liu, Ji Yu, Xin Yang, Ming Yang, Yanan He, Li Han, Dingkun Zhang
Background: Aconiti Lateralis Radix Praeparata , also known as Fuzi in Chinese, has been used in Traditional Chinese Medicine for more than 2,000 years. In recent years, some traditional herbal compounds containing Fuzi have achieved positive clinical results in tumor treatment. And the polysaccharide isolated from Fuzi has attracted much attention as a potential immunomodulator. However, its immunomodulatory mechanism remains to be further studied. Aim of the study. Fuzi neutral polysaccharide (FNPS) and cyclophosphamide (CTX) were combined to treat Hepatoma 22 (H22) tumor-bearing mice, and its mechanism of ameliorating immunosuppression caused by CTX was studied...
2023: Frontiers in Pharmacology
#37
JOURNAL ARTICLE
David W Eyre, Matthias Futschik, Sarah Tunkel, Jia Wei, Joanna Cole-Hamilton, Rida Saquib, Nick Germanacos, Andrew R Dodgson, Paul E Klapper, Malur Sudhanva, Chris Kenny, Peter Marks, Edward Blandford, Susan Hopkins, Tim E A Peto, Tom Fowler
BACKGROUND: Antigen lateral flow devices (LFDs) have been widely used to control SARS-CoV-2. We aimed to improve understanding of LFD performance with changes in variant infections, vaccination, viral load, and LFD use, and in the detection of infectious individuals. METHODS: In this diagnostic study, paired LFD and RT-PCR test results were prospectively collected from asymptomatic and symptomatic participants in the UK between Nov 4, 2020, and March 21, 2022, to support the National Health Service (NHS) England's Test and Trace programme...
March 28, 2023: Lancet Infectious Diseases
#38
REVIEW
Alicia Monreal-Bartolomé, Alberto Barceló-Soler, Javier García-Campayo, Cruz Bartolomé-Moreno, Paula Cortés-Montávez, Esther Acon, María Huertes, Víctor Lacasa, Sofía Crespo, Daniel Lloret-Irles, Luis Sordo, Catrina Clotas Bote, Susanna Puigcorbé, Yolanda López-Del-Hoyo
Gambling disorder in youth is an emerging public health problem, with adolescents and young adults constituting a vulnerable age group for the development of gambling-related problems. Although research has been conducted on the risk factors for gambling disorder, very few rigorous studies can be found on the efficacy of preventive interventions in young people. The aim of this study was to provide best practice recommendations for the prevention of disordered gambling in adolescents and young adults. We reviewed and synthesized the results of existing RCTs and quasi-experimental studies covering nonpharmacological prevention programs for gambling disorder in young adults and adolescents...
March 7, 2023: International Journal of Environmental Research and Public Health
#39
JOURNAL ARTICLE
Susanna Asseyer, Nasrin Asgari, Jeffrey Bennett, Omer Bialer, Yolanda Blanco, Francesca Bosello, Anna Camos-Carreras, Edgar Carnero Contentti, Sara Carta, John Chen, Claudia Chien, Mashina Chomba, Russell C Dale, Josep Dalmau, Kristina Feldmann, Eoin P Flanagan, Caroline Froment Tilikete, Carolina Garcia-Alfonso, Joachim Havla, Mark Hellmann, Ho Jin Kim, Philipp Klyscz, Frank Konietschke, Chiara La Morgia, Marco Lana-Peixoto, Maria Isabel Leite, Netta Levin, Michael Levy, Sara Llufriu, Pablo Lopez, Itay Lotan, Alessandra Lugaresi, Romain Marignier, Sara Mariotto, Susan P Mollan, Cassandra Ocampo, Frederike Cosima Oertel, Maja Olszewska, Jacqueline Palace, Lekha Pandit, José Luis Peralta Uribe, Sean Pittock, Sudarshini Ramanathan, Natthapon Rattanathamsakul, Albert Saiz, Sara Samadzadeh, Bernardo Sanchez-Dalmau, Deanna Saylor, Michael Scheel, Tanja Schmitz-Hübsch, Jemal Shifa, Sasitorn Siritho, Pia S Sperber, Prem S Subramanian, Alon Tiosano, Adi Vaknin-Dembinsky, Alvaro Jose Mejia Vergara, Adi Wilf-Yarkoni, Luis Alfonso Zarco, Hanna G Zimmermann, Friedemann Paul, Hadas Stiebel-Kalish
UNLABELLED: Optic neuritis (ON) often occurs at the presentation of multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD). The recommended treatment of high-dose corticosteroids for ON is based on a North American study population, which did not address treatment timing or antibody serostatus. The Acute Optic Neuritis Network (ACON) presents a global, prospective, observational study protocol primarily designed to investigate the effect of time to high-dose corticosteroid treatment on 6-month visual outcomes in ON...
2023: Frontiers in Neurology
#40
JOURNAL ARTICLE
Yu-Feng Huang, Han-Yue Li, Jun-Xiu Guo, Meng-Xian Wang, Zi-Qi Yang, Xin-Yue Bai, Zhong-De Zhang, Rong-Yuan Yang, Liang Liu, Hua Zhou, Fan He
As an empirical medicine of traditional Chinese medicine, Fuzhengjiedu Granules have shown an effect against COVID-19 in clinical and inflammatory animal models. It is formulated with eight herbs, including Aconiti Lateralis Radix Praeparata , Zingiberis Rhizoma , Glycyrrhizae Radix Et Rhizoma , Lonicerae Japonicae Flos , Gleditsiae Spina , Fici Radix , Pogostemonis Herba , and Citri Reticulatae Pericarpium . This study established a high-performance liquid chromatography-triple quadrupole mass spectrometry (HPLC-QQQ-MS/MS) method by simultaneously determining 29 active compounds in the granules with significant content differences...
February 2023: Heliyon
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