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https://www.readbyqxmd.com/read/28319754/association-between-harm-reduction-intervention-uptake-and-skin-and-soft-tissue-infections-among-people-who-inject-drugs
#1
Karen Dunleavy, Alison Munro, Kirsty Roy, Sharon Hutchinson, Norah Palmateer, Tony Knox, David Goldberg, Avril Taylor
BACKGROUND: Bacterial skin and soft tissue infections (SSTIs) are a health issue for people who inject drugs (PWID). There is a lack of evidence on the associations between harm reduction (HR) uptake and SSTIs. This paper examines the associations between the uptake of injecting equipment (IE) and opiate substitution treatment (OST) on SSTIs among PWID, and the injecting behaviours associated with having had an SSTI. This is the first large-scale, national study to examine the association between IE uptake and SSTIs...
March 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28261635/association-of-serum-lipids-and-coronary-artery-disease-with-polymorphisms-in-the-apolipoprotein-ai-ciii-aiv-gene-cluster
#2
Himanshu Rai, Nakul Sinha, James Finn, Suraksha Agrawal, Sarabjit Mastana
Genetic variants are considered as one of the main determinants of the concentration of serum lipids and coronary artery disease (CAD). Polymorphisms in the Apolipoprotein (Apo) AI-CIII-AIV gene cluster has been known to affect the concentrations of various lipid sub-fractions and the risk of CAD. The present study assessed associations between polymorphisms of the Apo AI-CIII-AIV gene cluster, [ApoA-I,-75G > A, (rs1799837); ApoC-III 3238C > G, (SstI), (rs5128) and ApoA-IV, Thr347Ser(347A > T), (rs675)] with serum lipids and their contributions to CAD in North Indian population...
December 31, 2016: Cogent Med
https://www.readbyqxmd.com/read/28255603/intraoperative-diagnosis-of-staphylococcus-aureus-and-coagulase-negative-staphylococcus-using-xpert-mrsa-sa-ssti-assay-in-prosthetic-joint-infection
#3
Andrea Sambri, Giovanni Pignatti, Matteo Romagnoli, Davide Donati, Maurilio Marcacci, Matteo Cadossi
The aim of this prospective study was to evaluate the performance of the Polymerase Chain Reaction (PCR) tool Xpert MRSA/SA SSTI test (Cepheid, Sunnyvale, CA, USA) on periprosthetic samples from a cohort of patients with suspected prosthetic joint infection (PJI). Seventy adult patients were included in this prospective study. On the basis of the preoperative evaluation, 39 patients were clinically considered to have a PJI, whereas 31 were presumed to suffer from an aseptic mobilization of the implant. Xpert MRSA/SA SSTI identified 4 out of 4 MRSA, 7 out of 7 MSSA, and 14 out of 16 methicillin resistant CoNS...
March 1, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28210352/risk-of-skin-and-soft-tissue-infections-among-children-found-to-be-staphylococcus-aureus-mrsa-usa300-carriers
#4
Lilly Cheng Immergluck, Shabnam Jain, Susan M Ray, Robert Mayberry, Sarah Satola, Trisha Chan Parker, Keming Yuan, Anaam Mohammed, Robert C Jerris
INTRODUCTION: The purpose of this study was to examine community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) carriage and infections and determine risk factors associated specifically with MRSA USA300. METHODS: We conducted a case control study in a pediatric emergency department. Nasal and axillary swabs were collected, and participants were interviewed for risk factors. The primary outcome was the proportion of S. aureus carriers among those presenting with and without a skin and soft tissue infection (SSTI)...
February 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28073795/in-patients-presenting-to-the-emergency-department-with-skin-and-soft-tissue-infections-what-is-the-diagnostic-accuracy-of-point-of-care-ultrasonography-for-the-diagnosis-of-abscess-compared-to-the-current-standard-of-care-a-systematic-review-and-meta-analysis
#5
David Barbic, Jordan Chenkin, Dennis D Cho, Tomislav Jelic, Frank X Scheuermeyer
OBJECTIVES: The primary objective of this systematic review was to determine the accuracy of point-of-care ultrasonography (POCUS) in diagnosing abscess in emergency department (ED) patients with skin and soft tissue infections (SSTI). The secondary objective was the accuracy of POCUS in the paediatric population subgroup. SETTING: Prospective studies set in emergency departments. PARTICIPANTS: Emergency department patients (adult and paediatric) presenting with SSTI and suspected abscess...
January 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28055287/epidemiology-treatment-and-economics-of-patients-presenting-to-the-emergency-department-for-skin-and-soft-tissue-infections
#6
Kristin E Linder, David P Nicolau, Michael D Nailor
OBJECTIVES: Skin and soft tissue infections (SSTIs) are among the most common bacterial diseases and represent a significant disease burden. The purpose of this study was to describe the real-world management of patients with SSTIs presenting to the emergency department (ED). METHODS: This is a retrospective cohort study. Adult patients identified with a primary diagnosis of SSTI determined by ICD-9 codes were assessed from index presentation for up to 30 days...
February 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/28052529/successful-salvage-and-reconstruction-of-a-finger-threatened-by-vibrio-vulnificus-necrotising-fasciitis-using-fenestrated-type-artificial-dermis-and-three-steps-of-topical-negative-pressure-wound-therapy
#7
Chi-Yu Wang, Hao-Yu Chiao, Chang-Yi Chou, Chien-Ju Wu, Chun-Kai Chang, Tzi-Shiang Chu, Niann-Tzyy Dai
Vibrio vulnificus can cause severe skin and soft tissue infection (SSTI). The pathogen is an opportunistic marine bacterium that is likely to infect patients with chronic liver disease, patients in an immunocompromised state, and those in end-stage renal disease. V. vulnificus gains entry through soft tissues by direct penetration of a wound by infected marine organisms, such as raw oysters, shellfish and other seafood, or by exposing a wound to contaminated water. Despite its ease of entry, V. vulnificus necrotising fasciitis with compartment syndrome has rarely been described...
January 4, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28031850/isolated-mycobacterium-kansasii-wound-infection-and-osteomyelitis-in-an-immunocompetent-patient
#8
Tarek Turk, Mohamed Faher Almahmoud, Khulood Raslan
Mycobacterium kansasii is a slow growing acid-fast non-tuberculosis mycobacterium. It most commonly causes pulmonary disease with tuberculosis-like manifestations. Mycobacterium kansasii-induced skin and soft tissue infections (SSTIs) are very uncommon, especially in the absence of obvious risk factors. In this report, we present a rare case of M. kansasii-associated SSTI complicated by tendonitis and osteomyelitis in an immunocompetent patient. This case highlights the importance of considering non-tuberculosis mycobacteria while investigating chronic, relapsing, non-healing SSTIs and osteomyelitis...
November 2016: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28004323/rapid-mrsa-pcr-on-respiratory-specimens-from-ventilated-patients-with-suspected-pneumonia-a-tool-to-facilitate-antimicrobial-stewardship
#9
S E Trevino, M A Pence, J Marschall, M H Kollef, H M Babcock, C-A D Burnham
Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of pneumonia in ventilated patients. Our objective was to evaluate the GeneXpert MRSA/SA SSTI Assay (Xpert MRSA/SA) (Cepheid, Sunnyvale, CA) for use in lower respiratory tract (LRT) specimens for rapid MRSA detection and to determine the potentially saved antibiotic-days if a culture-based identification method was replaced by this assay. Remnant LRT samples from ventilated patients submitted to the microbiology laboratory for routine culture were tested using conventional culture and Xpert MRSA/SA...
December 21, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27999423/characterization-of-community-associated-staphylococcus-aureus-from-skin-and-soft-tissue-infections-a-multicenter-study-in-china
#10
MULTICENTER STUDY
Ying Liu, Zhe Xu, Zhou Yang, Juan Sun, Lin Ma
We evaluated the epidemiological and molecular features of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and methicillin-sensitive S. aureus (MSSA) from children and adult patients with skin and soft-tissue infections (SSTIs) in China. Prospective community-acquired S. aureus SSTI surveillance was conducted in 23 hospitals over a 24-month period. Susceptibility to 16 antimicrobials was evaluated using the agar dilution method. StatApriori was used to determine statistically significant association trends...
December 21, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27922625/infections-in-the-spinal-cord-injured-population-a-systematic-review
#11
L Y Garcia-Arguello, J C O'Horo, A Farrell, R Blakney, M R Sohail, C T Evans, N Safdar
STUDY DESIGN: Spinal cord injury (SCI) patients are an increasing population due to recent military conflicts. SCI patients are at an increased risk of infection, but the epidemiology management and prevention strategies for these infections are unclear. OBJECTIVE: To review the incidence, microbiology and management of pneumonia, skin and soft tissue infections (SSTI), urinary tract infections (UTI) and bloodstream infections in the SCI population via literature review...
December 6, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27917738/incidence-and-factors-associated-with-emergency-department-visits-for-recurrent-skin-and-soft-tissue-infections-in-patients-in-california-2005-2011
#12
L May, E Y Klein, E M Martinez, N Mojica, L G Miller
More than 2 million visits for skin and soft tissue infections (SSTIs) are seen in US emergency departments (EDs) yearly. Up to 50% of patients with SSTIs, suffer from recurrences, but associated factors remain poorly understood. We performed a retrospective study of patients with primary diagnosis of SSTI between 2005 and 2011 using California ED discharge data from the State Emergency Department Databases and State Inpatient Databases. Using a multivariable logistic regression, we examined factors associated with a repeat SSTI ED visits up to 6 months after the initial SSTI...
December 5, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27902667/managing-skin-and-soft-tissue-infections-in-the-emergency-department-observation-unit
#13
Shabana Yusuf, Joseph L Hagan, Aderonke O Adekunle-Ojo
BACKGROUND: Skin and soft tissue infections (SSTIs) are a common reason for presentation to the emergency department (ED) and account for 3% of ED visits. Patients with a diagnosis of cellulitis requiring intravenous (IV) antibiotics have traditionally been admitted to the hospital. In our institution, these patients are placed in the ED Observation Unit (EDOU) for IV antibiotics. OBJECTIVES: The purpose of this study is to determine if 3 doses of IV antibiotics are adequate to document clinical improvement in children with uncomplicated SSTI...
December 2, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27899072/appropriateness-of-antibiotic-management-of-uncomplicated-skin-and-soft-tissue-infections-in-hospitalized-adult-patients
#14
Thomas L Walsh, Lynn Chan, Chelsea I Konopka, Michael J Burkitt, Matthew A Moffa, Derek N Bremmer, Monika A Murillo, Courtney Watson, Noreen H Chan-Tompkins
BACKGROUND: Skin and soft tissue infections (SSTIs) are a leading cause for hospitalizations in the United States. Few studies have addressed the appropriateness of antibiotic therapy in the management of SSTIs without complicating factors. We aimed to determine the appropriateness of antibiotic treatment duration for hospitalized adult patients with uncomplicated SSTIs. METHODS: This was a retrospective analysis performed at two academic medical centers in Pittsburgh, Pennsylvania on patients aged 18 years and older with primary ICD-9 code for SSTIs admitted August 1st, 2014-March 31st, 2015...
November 29, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27897966/behavioral-characteristics-and-injection-practices-associated-with-skin-and-soft-tissue-infections-among-people-who-inject-drugs-a-community-based-observational-study
#15
Disa Dahlman, Anders Håkansson, Alex H Kral, Lynn Wenger, Elizabeth L Ball, Scott P Novak
BACKGROUND: People who inject drugs (PWID) are at increased risk for bacterial skin and soft tissue infections (SSTIs). Although SSTIs pose significant health risks, little is known about their prevalence and characteristics in the population of PWID in the United States. This study investigates whether behavioral factors related to skin and equipment hygiene and tissue-damaging injection practices are associated with recent SSTIs among PWID. METHODS: Active PWID were recruited using targeted sampling in San Francisco in 2011-2013...
January 2017: Substance Abuse
https://www.readbyqxmd.com/read/27891094/anti-acne-activity-of-italian-medicinal-plants-used-for-skin-infection
#16
Kate Nelson, James T Lyles, Tracy Li, Alessandro Saitta, Eugenia Addie-Noye, Paula Tyler, Cassandra L Quave
Propionibacterium acnes is implicated in the pathogenesis of acne vulgaris, which impacts >85% of teenagers. Novel therapies are in high demand and an ethnopharmacological approach to discovering new plant sources of anti-acne therapeutics could contribute to filling this void in effective therapies. The aims of our study were two-fold: (1) To determine if species identified in ethnopharmacological field studies as having traditional uses for skin and soft tissue infection (SSTI) exhibit significantly more activity against P...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27876477/current-prescribing-practices-for-skin-and-soft-tissue-infections-in-nursing-homes
#17
Diana Feldstein, Philip D Sloane, David Weber, Kimberly Ward, David Reed, Sheryl Zimmerman
OBJECTIVES: Antibiotic stewardship has been called for across all sites of health care, including nursing homes (NHs). Skin and soft tissue infections (SSTIs) are the third most common indication for antibiotics in the NH, and so should be a focus of stewardship. This study audited medical records to identify signs and symptoms of SSTIs treated with antibiotics in relation to the McGeer criteria for surveillance, the Loeb minimum criteria for antibiotic initiation, and prescribing recommendations of the Infectious Disease Society of America...
March 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27852674/focus-on-mrsa-sa-ssti-assay-failure-in-prosthetic-joint-infections-213-consecutive-patients-later
#18
LETTER
Marie Titécat, Frédéric Wallet, Olivier Robineau, Michel Valette, Henri Migaud, Eric Senneville, Caroline Loïez
No abstract text is available yet for this article.
February 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27851746/livestock-associated-antibiotic-resistant-staphylococcus-aureus-nasal-carriage-and-recent-skin-and-soft-tissue-infection-among-industrial-hog-operation-workers
#19
Maya Nadimpalli, Jill R Stewart, Elizabeth Pierce, Nora Pisanic, David C Love, Devon Hall, Jesper Larsen, Karen C Carroll, Tsigereda Tekle, Trish M Perl, Christopher D Heaney
Swine production work is a risk factor for nasal carriage of livestock-associated (LA-) Staphylococcus aureus and also for skin and soft tissue infection (SSTI). However, whether LA-S. aureus nasal carriage is associated with increased risk of SSTI remains unclear. We aimed to examine S. aureus nasal carriage and recent (≤3 months prior to enrollment) SSTI symptoms among industrial hog operation (IHO) workers and their household contacts. IHO workers and their household contacts provided a nasal swab and responded to a questionnaire assessing self-reported personal and occupational exposures and recent SSTI symptoms...
2016: PloS One
https://www.readbyqxmd.com/read/27820584/ca-mrsa-decolonization-strategies-do-they-reduce-recurrence-rate
#20
Joling Tidwell, Lisa Kirk, Tim Luttrell, Caitlin A Pike
BACKGROUND: Community-associated methicillin-resistant Staphylococcus aureus commonly presents as a skin and soft tissue infection. Recurrence of the infection is common even after incision and drainage of the affected area. OBJECTIVE: This Evidence-Based Report Card reviews whether decolonization strategies will reduce the rate of methicillin-resistant Staphylococcus aureus skin and soft tissue infection (MRSA-SSTI) recurrence or colonization in patients with a history of MRSA-SSTI...
November 2016: Journal of Wound, Ostomy, and Continence Nursing
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