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Belén Abarrategui, Luciana Rodrigues De Marchi, Mirian Salvadori Bittar Guaranha, Elza Márcia Targas Yacubian
PURPOSE: To characterize semiology and EEG features of praxis-induced (PI) myoclonia and to describe the subjective perception of juvenile myoclonic epilepsy (JME) patients with this reflex trait. METHODS: Patients with JME who presented myoclonia during a Video-EEG Neuropsychological Protocol were selected. We analyzed the semiology of upper limbs myoclonia and the ictal EEG patterns on Video-EEG. We explored the subjective aspects of PI by performing a semi-structured interview to each patient...
June 30, 2018: Seizure: the Journal of the British Epilepsy Association
Fabrício Stewan Feltrin, Ana Luiza Zaninotto, Vinícius M P Guirado, Fabiola Macruz, Daniel Sakuno, Mariana Dalaqua, Luiz Gustavo Antunes Magalhães, Wellingson Silva Paiva, Almir Ferreira de Andrade, Maria C G Otaduy, Claudia C Leite
BACKGROUND AND OBJECTIVE: Diffuse axonal injury (DAI) induces a long-term process of brain atrophy and cognitive deficits. The goal of this study was to determine whether there are correlations between brain volume loss, microhaemorrhage load (MHL) and neuropsychological performance during the first year after DAI. METHODS: Twenty-four patients with moderate or severe DAI were evaluated at 2, 6 and 12 months post-injury. MHL was evaluated at 3 months, and brain volumetry was evaluated at 3, 6 and 12 months...
July 19, 2018: Brain Injury: [BI]
Jeong-Hee Yang, Han Do Lee, So Young Kwak, Ki Hyun Byun, Sung Ho Park, Dongseok Yang
It is not clear whether the fornix and cingulum are involved in cognition after putaminal hemorrhage (PH). We investigated structural changes and differences of the neural tracts, and the relationship between the integrity of the neural tracts and cognition not only at the affected but also at the unaffected side.Sixteen patients with left chronic putaminal hemorrhage and 20 healthy volunteers were enrolled. Using diffusion tensor tractography (DTT), we compared fiber number (FN), fractional anisotropy (FA), and apparent diffusion coefficient (ADC) of the neural tracts between patient and control groups...
July 2018: Medicine (Baltimore)
Guannan Shen, Nathan J Smyk, Andrew N Meltzoff, Peter J Marshall
The focus of the current study is on a particular aspect of tactile perception: categorical segmentation on the body surface into discrete body parts. The MMN has been shown to be sensitive to categorical boundaries and language experience in the auditory modality. Here we recorded the somatosensory MMN (sMMN) using two tactile oddball protocols and compared sMMN amplitudes elicited by within- and across-boundary oddball pairs. Both protocols employed the identity MMN method that controls for responsivity at each body location...
July 19, 2018: Journal of Cognitive Neuroscience
Gavin Buckingham, Desiree Holler, Elizabeth E Michelakakis, Jacqueline C Snow
Object interaction requires knowledge of the weight of an object, as well as its shape. The lateral occipital complex (LOC), an area within the ventral visual pathway, is well known to be critically involved in processing visual shape information. Recently, however, LOC has also been implicated in coding object weight before grasping-a result that is surprising because weight is a nonvisual object property that is more relevant for motor interaction than visual perception. Here, we examined the causal role of LOC in perceiving heaviness and in determining appropriate fingertip forces during object lifting...
July 19, 2018: Journal of Cognitive Neuroscience
Erica Weber, Angela Spirou, Nancy Chiaravalloti, Jeannie Lengenfelder
OBJECTIVE: To explore the contribution of frontal systems behavioral dysfunction on employment outcomes in individuals with traumatic brain injury (TBI), in the context of relevant predictors of work status. METHOD: Forty-two participants with history of moderate-to-severe TBI were classified as either "Employed" or "Unemployed." Groups did not differ on most demographic or injury variables, although the Unemployed sample reported greater symptoms of depression, pain, and fatigue ( p s < 0...
July 19, 2018: Rehabilitation Psychology
Omur Gulsum Deniz, Suleyman Kaplan, Mustafa Bekir Selçuk, Murat Terzi, Gamze Altun, Kıymet Kübra Yurt, Kerim Aslan, Devra Davis
The increasing use of mobile phones may have a number of physiological and psychological effects on human health. Many animal and human studies have reported various effects on the central nervous system and cognitive performance from of exposure to electromagnetic fields (EMF) emitted by mobile phones. The aim of the present study was to evaluate the effects of mobile phones on the morphology of the human brain and on cognitive performance using stereological and spectroscopic methods and neurocognitive tests...
October 2017: Journal of microscopy and ultrastructure
Monica Consonni, Valeria E Contarino, Eleonora Catricalà, Eleonora Dalla Bella, Viviana Pensato, Cinzia Gellera, Giuseppe Lauria, Stefano F Cappa
Amyotrophic lateral sclerosis (ALS) can be associated with a spectrum of cognitive and behavioural symptoms, but the related patterns of focal cortical atrophy in non-demented ALS patients remain largely unknown. We enrolled 48 non-demented ALS patients and 26 healthy controls for a comprehensive neuropsychological assessment and a magnetic resonance exam. Behavioural and cognitive impairment was defined on the basis of a data-driven multi-domain approach in 21 ALS patients. Averaged cortical thickness of 74 bilateral brain regions was used as a measure of cortical atrophy...
2018: NeuroImage: Clinical
Jaclyn M Kamradt, Allison M Momany, Molly A Nikolas
Attention-deficit hyperactivity disorder (ADHD) persists into adulthood in over 50% of cases, although its associated symptom profiles, comorbid problems, and neuropsychological deficits change substantially across development. Sluggish cognitive tempo (SCT) symptoms may contribute to associations between ADHD and comorbid problems and may partially explain the substantial heterogeneity observed in its correlates. 349 adults aged 18-38 years (M = 23.2, SD = 4.5, 54.7% male, 61.03% with ADHD) completed a multi-informant diagnostic procedure and a comprehensive neuropsychological battery...
June 2018: Journal of Psychopathology and Behavioral Assessment
Soham Rej, Sarah Waters Schulte, Tarek K Rajji, Ariel G Gildengers, Dielle Miranda, Mahesh Menon, Meryl A Butters, Benoit H Mulsant
OBJECTIVES: Recent data suggests that statins have positive effects on cognition in older adults. Studies in patients with mood disorders have found contradicting positive and negative effects of statins on mood and cognition, with limited data in bipolar disorder (BD). The objective of this study was to assess the association between statin use and cognition in older adults with BD. METHODS: In a cross-sectional sample of 143 euthymic older adults with BD (age ≥ 50), statin users (n = 48) and nonusers (n = 95) were compared for cognitive outcomes: Global and cognitive domain z-scores were calculated from detailed neuropsychological batteries using normative data from healthy comparators (n = 87)...
July 19, 2018: International Journal of Geriatric Psychiatry
Ryan Van Patten, Karysa Britton, Geoffrey Tremont
ABSTRACTObjectives:To show enhanced psychometric properties and clinical utility of the modified Mini-Mental State Examination (3MS) compared to the Mini-Mental State Examination (MMSE) in mild cognitive impairment (MCI). DESIGN: Psychometric and clinical comparison of the 3MS and MMSE. SETTING: Neuropsychological clinic in the northeastern USA. PARTICIPANTS: Older adults referred for cognitive concerns, 87 of whom were cognitively intact (CI) and 206 of whom were diagnosed with MCI...
July 19, 2018: International Psychogeriatrics
Morris Freedman, Larry Leach, M Carmela Tartaglia, Kathryn A Stokes, Yael Goldberg, Robyn Spring, Nima Nourhaghighi, Tom Gee, Stephen C Strother, Mohammad O Alhaj, Michael Borrie, Sultan Darvesh, Alita Fernandez, Corinne E Fischer, Jennifer Fogarty, Barry D Greenberg, Michelle Gyenes, Nathan Herrmann, Ron Keren, Josh Kirstein, Sanjeev Kumar, Benjamin Lam, Suvendrini Lena, Mary Pat McAndrews, Gary Naglie, Robert Partridge, Tarek K Rajji, William Reichmann, M Uri Wolf, Nicolaas P L G Verhoeff, Jordana L Waserman, Sandra E Black, David F Tang-Wai
BACKGROUND: A need exists for easily administered assessment tools to detect mild cognitive changes that are more comprehensive than screening tests but shorter than a neuropsychological battery and that can be administered by physicians, as well as any health care professional or trained assistant in any medical setting. The Toronto Cognitive Assessment (TorCA) was developed to achieve these goals. METHODS: We obtained normative data on the TorCA (n = 303), determined test reliability, developed an iPad version, and validated the TorCA against neuropsychological assessment for detecting amnestic mild cognitive impairment (aMCI) (n = 50/57, aMCI/normal cognition)...
July 18, 2018: Alzheimer's Research & Therapy
Jolien Schaeverbeke, Silvy Gabel, Karen Meersmans, Rose Bruffaerts, Antonietta Gabriella Liuzzi, Charlotte Evenepoel, Eva Dries, Karen Van Bouwel, Anne Sieben, Yolande Pijnenburg, Ronald Peeters, Guy Bormans, Koen Van Laere, Michel Koole, Patrick Dupont, Rik Vandenberghe
BACKGROUND: A subset of patients with the nonfluent variant of primary progressive aphasia (PPA) exhibit concomitant single-word comprehension problems, constituting a 'mixed variant' phenotype. This phenotype is rare and currently not fully characterized. The aim of this study was twofold: to assess the prevalence and nature of single-word comprehension problems in the nonfluent variant and to study multimodal imaging characteristics of atrophy, tau, and amyloid burden associated with this mixed phenotype...
July 18, 2018: Alzheimer's Research & Therapy
(no author information available yet)
No abstract text is available yet for this article.
August 2018: Clinical Neuropsychologist
Daniela Smirni, Janelle N Beadle, Sergio Paradiso
The present study examined the degree to which alexithymia is greater in mild Alzheimer's disease (AD) and mild cognitive impairment (MCI) relative to healthy volunteers (healthy comparison [HC]), and investigated relationships between alexithymia and cognition. Eighty-five participants (MCI = 30, AD = 21, HC = 34) underwent a comprehensive neuropsychological examination and completed the 20-item Toronto Alexithymia Scale (TAS-20). Relative to HC, MCI and AD reported greater alexithymia total scores and higher scores on the TAS factor difficulty in identifying feelings (DIF)...
July 17, 2018: Journal of Nervous and Mental Disease
Daniel D Kurylo, Richard Waxman, Steven M Silverstein, Batya Weinstein, Jacob Kader, Ioannis Michalopoulos
INTRODUCTION: Impaired perceptual organisation in schizophrenia has been repeatedly described in clinical and research literatures. It has also been associated with problems in more complex aspects of visual function, including visuospatial and visual cognitive test performance. Two therapeutic interventions were developed here that target perceptual organisation: (1) Computer-based training, which emphasized stimulus-driven processing (bottom-up approach), and (2) Instrumental Enrichment therapy, which is a therapist-guided interactive learning method (top-down approach)...
July 18, 2018: Cognitive Neuropsychiatry
Hanna B Cygan, Hanna Okuniewska, Katarzyna Jednoróg, Artur Marchewka, Marek Wypych, Anna Nowicka
The ability to "read" the information about facial identity, expressed emotions, and intentions is crucial for non‑verbal social interaction. Neuroimaging and clinical studies consequently link face perception with fusiform gyrus (FG) and occipital face area (OFA) activity. Here we investigated face processing in an adult, patient PK, diagnosed with both high functioning autism spectrum disorder (ASD) and developmental prosopagnosia (DP). Both disorders have a significant impact on face perception and recognition, thus creating a unique neurodevelopmental condition...
2018: Acta Neurobiologiae Experimentalis
Foteini Christidi, Efstratios Karavasilis, Georgios Velonakis, Panagiotis Ferentinos, Michail Rentzos, Nikolaos Kelekis, Ioannis Evdokimidis, Peter Bede
Hippocampal pathology in Amyotrophic Lateral Sclerosis (ALS) remains surprisingly under recognized despite compelling evidence from neuropsychology, neuroimaging and neuropathology studies. Hippocampal dysfunction contributes significantly to the clinical heterogeneity of ALS and requires structure-specific cognitive and neuroimaging tools for accurate in vivo evaluation. Recent imaging studies have generated unprecedented insights into the presymptomatic and longitudinal processes affecting this structure and have contributed to the characterisation of both focal and network-level changes...
2018: Frontiers in Neurology
Daniel J Blackburn, Ptolemaios G Sarrigiannis, Matteo De Marco, Yifan Zhao, Annalena Venneri, Sarah Lawrence, Zoe C Unwin, Michelle Blyth, Jenna Angel, Kathleen Baster, Iain D Wilkinson, Simon M Bell, Fei He, Hua-Liang Wei, Stephen A Billings, Thomas F D Farrow
BACKGROUND: The incidence of Alzheimer disease (AD) is increasing with the ageing population. The development of low cost non-invasive diagnostic aids for AD is a research priority. This pilot study investigated whether an approach based on a novel dynamic quantitative parametric EEG method could detect abnormalities in people with AD. METHODS: 20 patients with probable AD, 20 matched healthy controls (HC) and 4 patients with probable fronto temporal dementia (FTD) were included...
July 17, 2018: Brain Sciences
Patricia Rzezak, Sylvie Paes Moschetta, Melanie Mendonça, Maria Luisa Maia Nobre Paiva, Ana Carolina Coan, Carlos Guerreiro, Kette Dualibi Ramos Valente
Executive deficits and impulsiveness are extensively reported in juvenile myoclonic epilepsy (JME). Previous literature suggests that intelligence may mediate these deficits. In this study, we evaluated and compared the performance of adults with JME with high and low intelligence quotient (IQ) and controls on tasks for executive function (EF) and impulsive traits. We investigated the neuropsychological performance of 53 adults with JME and below average IQ (57% women; 26.9 [±7.88] years; mean IQ: 89.8 [±5...
July 13, 2018: Epilepsy & Behavior: E&B
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