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https://www.readbyqxmd.com/read/28937066/relationship-of-insulin-resistance-to-vitamin-d-status-in-children-with-nondiabetic-chronic-kidney-disease
#1
Seçil Conkar, Sevgi Mir
Insulin Resistance is common in patients with mild-to-moderate stage chronic kidney disease (CKD), even when the glomerular filtration rate is within the normal range. This study aimed to investigate the association of IR and 25-hydroxyvitamin D levels. In this study, we evaluated the frequency of IR in predialysis patients and the association with 25-hydroxyvitamin (OH)D levels. A total of 32 non-diabetic patients with predialysis were included in the study. Homeostasis model assessment for insulin resistance (HOMA-IR) index was calculated to show presence of IR...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28937064/nephrocalcinosis-among-children-at-king-hussein-medical-center-causes-and-outcome
#2
Jwaher T Al-Bderat, Reham I Mardinie, Ghazi M Salaita, Amer T Al-Bderat, Mahdi K Farrah
Nephrocalcinosis (NC) is defined as deposition of calcium crystals in the renal parenchyma and tubules. This is a retrospective review of all the data of 63 children presented to Pediatric Nephrology Clinic at King Hussein Medical Center (KHMC) over a 15-year period with bilateral NC. We determine their causes, clinical presentation and evaluate their growth and renal function during their follow-up. Thirty-five (55.5%) cases were males and 28 (44.5%) were females. The median (range) age at presentation was four (2-192) months...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28937024/celiac-disease-related-osteopathy-among-saudi-celiac-patients-are-we-adherent-to-recommendations
#3
Mona A Fouda
BACKGROUND/AIMS: There are no reports from Saudi Arabia documenting the picture of osteopathy in celiac disease (CD) and the adherence of physicians to the guidelines and recommendations to screen for bone disease. We conducted this study to document the prevalence of CD-related osteopathy and the Saudi physicians' adherence to the screening recommendations. PATIENTS AND METHODS: We identified the biopsy proven CD cases diagnosed between 2003 and 2012. In addition to demographic data, we collected laboratory (serum calcium, phosphate, alkaline phosphatase, 25-dihydroxy vitamin D, and parathyroid hormone levels) and imaging [Dual-energy X-ray absorptiometry (DEXA)] data...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28936809/association-between-vitamin-d-and-carboxy-terminal-cross-linked-telopeptide-of-type-i-collagen-in-children-during-growth-hormone-replacement-therapy
#4
Ewelina Witkowska-Sędek, Anna Stelmaszczyk-Emmel, Anna Kucharska, Urszula Demkow, Beata Pyrżak
Growth hormone and insulin-like growth factor-1 (IGF-1) play a crucial role in the regulation of bone turnover. Adequate vitamin D status supports proper bone remodeling, leading to normal longitudinal bone growth and normal peak bone mass. The aim of this study was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] and carboxy-terminal cross-linked telopeptide of type I collagen (ICTP) in children and adolescents with growth hormone deficiency at baseline and during recombinant human growth hormone (rhGH) replacement therapy...
September 22, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28931584/use-of-a-super-child-approach-to-assess-the-vitamin-a-equivalence-of-moringa-oleifera-leaves-develop-a-compartmental-model-for-vitamin-a-kinetics-and-estimate-vitamin-a-total-body-stores-in-young-mexican-children
#5
Veronica Lopez-Teros, Jennifer Lynn Ford, Michael H Green, Guangwen Tang, Michael A Grusak, Luis Quihui-Cota, Tawanda Muzhingi, Mariela Paz-Cassini, Humberto Astiazaran-Garcia
Background: Worldwide, an estimated 250 million children <5 y old are vitamin A (VA) deficient. In Mexico, despite ongoing efforts to reduce VA deficiency, it remains an important public health problem; thus, food-based interventions that increase the availability and consumption of provitamin A-rich foods should be considered.Objective: The objectives were to assess the VA equivalence of (2)H-labeled Moringa oleifera (MO) leaves and to estimate both total body stores (TBS) of VA and plasma retinol kinetics in young Mexican children...
September 20, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28926829/continuous-subcutaneous-recombinant-parathyroid-hormone-1-34-infusion-in-the-management-of-childhood-hypoparathyroidism-associated-with-malabsorption
#6
Vrinda Saraff, Anya Rothenbuhler, Wolfgang Högler, Agnès Linglart
BACKGROUND/AIMS: Hypoparathyroidism associated with malabsorption can be particularly challenging to manage due to limited and erratic intestinal absorption of calcium and vitamin D analogues, resulting in episodes of hypo- or hypercalcaemia. We evaluated the role of continuous subcutaneous recombinant parathyroid hormone (rhPTH 1-34) infusion (CSPI) in children with hypoparathyroidism associated with intestinal malabsorption resistant to conventional therapy. METHOD: Four patients (8-13 years of age), with symptomatic hypocalcaemia resistant to conventional therapy, were started on CSPI (follow-up 3-8 years) in two paediatric endocrinology units in Europe...
September 19, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28925036/combining-food-based-dietary-recommendations-using-optifood-with-zinc-fortified-water-potentially-improves-nutrient-adequacy-among-4-to-6-year-old-children-in-kisumu-west-district-kenya
#7
Prosper Kujinga, Karin J Borgonjen-van den Berg, Cecilia Superchi, Hermine J Ten Hove, Elizabeth Opiyo Onyango, Pauline Andang'o, Valeria Galetti, Michael B Zimmerman, Diego Moretti, Inge D Brouwer
Children in developing countries often face multiple micronutrient deficiencies. Introduction of zinc-fortified water can increase zinc intake, but additional recommendations are required to address overall diet nutrient adequacy. We developed and tested food-based recommendations (FBRs) that included zinc-fortified water for children aged between 4 and 6 years from rural Kenya to achieve the best possible nutrient adequacy. Dietary intakes of 60 children aged 4-6 years, from Kisumu West district, Kenya, were assessed using a quantitative multipass 24-hr recall...
September 19, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28923762/translating-basic-research-into-clinical-practice-vitamin-d-in-asthma-mechanisms-of-action-and-considerations-for-clinical-trials
#8
REVIEW
Paul E Pfeffer, Catherine M Hawrylowicz
There is increasing interest in the therapeutic utility of vitamin D in asthma, supported by a significant body of evidence on epidemiological associations between vitamin D insufficiency and worse asthma control. In support of a causal relationship, vitamin D beneficially modulates diverse immunological pathways in heterogeneous asthma endotypes, regulating the actions of lymphocytes, mast cells, antigen-presenting cells and structural cells to dampen excessive inflammatory responses. Allergic asthma is characterised by a failure of immune tolerance, and development of pathological responses to inhaled aeroallergens, and vitamin D has been extensively shown to support immune regulation...
September 15, 2017: Chest
https://www.readbyqxmd.com/read/28923060/vitamin-d-status-and-neurodevelopment-and-growth-in-young-north-indian-children-a-secondary-data-analysis
#9
Ranadip Chowdhury, Sunita Taneja, Nita Bhandari, Ingrid Kvestad, Tor A Strand, Maharaj Kishan Bhan
BACKGROUND: Vitamin-D deficiency has been linked with impaired development in animal studies; however, the evidence from human studies is scanty. Evidence as to whether vitamin-D deficiency during early childhood affects growth is also limited and conflicting. We examined the extent to which vitamin-D deficiency (<10 ng/ml) is associated with neurodevelopment and physical growth in young children. METHODS: We used data from a randomized controlled trial (RCT) of daily folic acid and/ or vitamin B12 supplementation for six months in children aged 6 to 30 months conducted in Delhi, India...
September 18, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28922908/vitamin-d-status-in-internationally-adopted-children-the-experience-in-northwest-italy
#10
Irene Raffaldi, Silvia Garazzino, Giuseppina Ballardini, Mauro Zaffaroni, Nicolino Grasso, Gianni Bona, Pier-Angelo Tovo, Andrea Guala
BACKGROUND: The majority of internationally adopted children, before adoption, might have experienced malnutrition, exposure to infectious diseases, environmental deprivation and neglect; they could also develop medical problems such as vitamin D deficiency. Scantly data are available about vitamin D status in internationally adopted children and, to our knowledge, no report exists on Italian adoptees. METHODS: We carried out a prospective multicenter study, involving three Pediatric Centers in Piedmont, Italy, in order to collect information about 25-hydroxyvitamin D [25(OH)D] profile in adoptees, shortly after their arrival in Italy...
September 15, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28914773/vitamin-d-nutritional-status-and-its-related-factors-for-chinese-children-and-adolescents-in-2010-2012
#11
Yichun Hu, Jing Chen, Rui Wang, Min Li, Chunfeng Yun, Weidong Li, Yanhua Yang, Jianhua Piao, Xiaoguang Yang, Lichen Yang
Vitamin D plays a critical role in calcium and phosphate metabolism and helps maintain skeletal integrity in childhood, yet vitamin D status in Chinese children and adolescents is not well documented. The aim of this study was to assess the vitamin D status and analyze the risk factors for vitamin D deficiency in Chinese children and adolescents aged 6-17 years. Serum 25 hydroxyvitamin D (25(OH)D) was measured with a radioimmunoassay kit in 15,000 children and adolescent participants in the Chinese national nutrition and health survey (CNNHS) 2010-2012...
September 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28914205/vitamin-d-and-depression-the-evidence-from-an-indirect-clue-to-treatment-strategy
#12
Sok Kuan Wong, Kok Yong Chin, Soelaiman Ima-Nirwana
Depression is a common psychiatric disorder that decreases the quality of life and increases the mortality of patients. It incurs significant healthcare costs if left untreated. Even though intervention with antidepressants can reduce depressive symptoms, side effects are often an issue and relapse is very common. Vitamin D, commonly known as the sunshine vitamin, is an essential fat-soluble vitamin for the absorption of calcium to prevent rickets (children) and osteomalacia (adults). Evidence on a possible relationship between vitamin D deficiency and depression is growing...
September 13, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28906318/nutritional-state-and-feeding-behaviors-of-children-with-eosinophilic-esophagitis-and-gastroesophageal-reflux-disease
#13
Pooja Mehta, Glenn T Furuta, Taryn Brennan, Michelle L Henry, Nancy Creskoff Maune, Shikha S Sundaram, Calies Menard-Katcher, Dan Atkins, Faith Takurukura, Sandra Giffen, Zhaoxing Pan, Angela M Haas
OBJECTIVE: Because both gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are associated with malnutrition and feeding dysfunction, this study compares growth, nutrition and feeding behaviors in children with GERD and EoE. METHODS: Subjects aged 1-7 with GERD or EoE were enrolled in a prospective study. Assessments included length/height, weight, 3-day food diary, serum biomarkers of nutrition, and the Behavioral Pediatric Feeding Assessment Scale (BPFAS)...
September 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28902630/pseudohypoparathyroidism-type-1b-associated-with-assisted-reproductive-technology
#14
Monica Fernandez, Maria Jose Zambrano, Joel Riquelme, Claudia Castiglioni, Marie-Laure Kottler, Harald Jüppner, Veronica Mericq
Evidence suggests an increased incidence of imprinting disorders in children conceived by assisted reproductive technologies (ART). Maternal loss-of-methylation at GNAS exon A/B, observed in pseudohypoparathyroidism type 1b (PHP1B), leads to decreased expression of the stimulatory Gsα. We present a patient conceived by ART, who presented at age 4 years with delayed neurocognitive development and persistently increased creatine kinase (CK). At 6 years an elevated PTH was detected with normal calcium and a low 25(OH) vitamin D level (25OHD)...
September 13, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28902145/replacing-american-breakfast-foods-with-ready-to-eat-rte-cereals-increases-consumption-of-key-food-groups-and-nutrients-among-us-children-and-adults-results-of-an-nhanes-modeling-study
#15
Colin D Rehm, Adam Drewnowski
Replacing the typical American breakfast with ready-to-eat cereals (RTECs) may improve diet quality. Our goal was to assess the impact of RTECs on diet quality measures for different age groups, using substitution modeling. Dietary intakes came from the 2007-2010 National Health and Examination Surveys (NHANES; n = 18,112). All breakfast foods, excluding beverages, were replaced on a per calorie basis, with frequency-weighted and age/race specific RTECs. Model 1 replaced foods with RTECs alone; Model 2 replaced foods with RTECs and milk...
September 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28902093/bile-acid-synthesis-disorders-in-arabs-a-10-year-screening-study
#16
Abdulrahman Al-Hussaini, Kenneth D R Setchell, Bader AlSaleem, James E Heubi, Khurram Lone, Anne Davit-Spraul, Emmanuel Jacquemin
OBJECTIVES: Early diagnosis of bile acid synthesis disorders (BASD) is important because, untreated, these conditions can be fatal. Our objectives were to screen children with cholestasis or unexplained liver disease for BASD and in those with confirmed BASD to evaluate the effectiveness of cholic acid therapy. METHODS: A routine serum total bile acid measurement was performed on children with cholestasis, liver cirrhosis, and liver failure. Patients were screened for BASD by fast atom bombardment ionization-mass spectrometry (FAB-MS) analysis of urine, and molecular analysis confirmed diagnosis...
September 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28901336/vitamin-d-and-probiotics-supplement-use-in-young-children-with-genetic-risk-for-type-1-diabetes
#17
J Yang, R N Tamura, U M Uusitalo, C A Aronsson, K Silvis, A Riikonen, N Frank, G Joslowski, C Winkler, J M Norris, S M Virtanen
BACKGROUND/OBJECTIVES: Vitamin D and probiotics are nutrients of interest in the context of type 1 diabetes (T1D). We assessed the prevalence of and factors associated with vitamin D and probiotic supplementations among young children with genetic risk of T1D. SUBJECTS/METHODS: Use of supplements during the first 2 years of life was collected prospectively from 8674 children in The Environmental Determinants of Diabetes in the Young (TEDDY) study. RESULTS: Single and/or multivitamin/mineral (MVM) supplements were reported by 81% of the children...
September 13, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28900319/investigation-of-vitamin-d-receptor-gene-polymorphism-in-pediatric-patients-with-brain-cancer
#18
Baris Yilmaz, Gulnur Ayse Tokuc, Ahmet Koc, Edanur Yesil
AIM: In recent years, it is believed that Vitamin D may play a protective role in some cancer types. Certain regions of the Vitamin D receptor (VDR) gene may show a genetic difference in structure. The most frequent polymorphisms in this gene are in Taq-1, Fok-1, and Bsm-1 regions. Some adult cancer types are associated with VDR gene polymorphism such as; colorectal carcinoma, breast carcinoma, and prostate carcinoma. Reviewing the medical literature, no such study had been done on children so far...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28899463/-bone-metabolism-disorders-caused-by-sodium-valproate-therapy-in-children-with-epilepsy-and-the-prevention-of-the-disorders-by-supplementation-of-calcium-and-vitamin-d
#19
Ying-Wu Liang, Qing Feng, Yan-Li Zhang, Wen-Jun Wang
No abstract text is available yet for this article.
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28898870/short-term-vitamin-d3-supplementation-in-children-with-neurodisabilities-comparison-of-two-delivery-methods
#20
Francesca Penagini, Barbara Borsani, Katia Maruca, Valeria Giosia, Stefania Bova, Massimo Mastrangelo, Gian Vincenzo Zuccotti, Stefano Mora
BACKGROUND/AIMS: Vitamin D deficiency is common in children with neurodisabilities. Oral vitamin D3 may not be absorbed appropriately due to dysphagia and tube feeding. The aim of this study was to compare efficacy of vitamin D3 buccal spray with that of oral drops. METHODS: Twenty-four children with neurodisabilities (5-17 years) and vitamin D deficiency (25(OH)D ≤20 ng/mL) were randomized to receive vitamin D3 buccal spray 800 IU/daily (n = 12) or oral drops 750 IU/daily (n = 12) for 3 months during winter...
September 12, 2017: Hormone Research in Pædiatrics
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