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https://www.readbyqxmd.com/read/28652651/molecular-mimicry-in-helicobacter-pylori-infections
#1
REVIEW
Magdalena Chmiela, Weronika Gonciarz
Gram-negative bacteria Helicobacter pylori (H. pylori) colonize gastric mucosa in humans and increase the risk of serious diseases such as gastric and duodenal ulcers, stomach cancers and mucosa associated lymphoid tissue lymphoma. The role of H. pylori infection in the pathogenesis of several extragastric diseases has been suggested including immune thrombocytopenic purpura, iron deficiency anemia, vitamin D deficiency, cardiovascular diseases, diabetes mellitus and dermatological disorders. Also neurological diseases and even lung cancer have attracted researchers concern...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28651793/rapid-vs-maintenance-vitamin-d-supplementation-in-deficient-asthmatic-children-to-prevent-exacerbations
#2
Khalid Alansari, Bruce L Davidson, Khalid Ibrahim Yousef, Abdel Nasser H Mohamed, Imad Alattar
BACKGROUND: Whether vitamin D reduces clinically important exacerbations of childhood asthma remains uncertain. We compared rapid to maintenance vitamin D repletion analyzed by baseline vitamin D level. METHODS: Children presenting to the emergency department with moderate-severe asthma exacerbations and vitamin D levels <25ng/mL underwent masked randomization, then open dosing to either: IM+oral , the latter daily, therapy; or daily oral-only therapy, and were followed for 12 months...
June 23, 2017: Chest
https://www.readbyqxmd.com/read/28647736/no-severe-hypercalcemia-with-daily-vitamin-d3-supplementation-of-up-to-30-%C3%A2%C2%B5g-during-the-first-year-of-life
#3
Saara Valkama, Elisa Holmlund-Suila, Maria Enlund-Cerullo, Jenni Rosendahl, Helena Hauta-Alus, Otto Helve, Timo Hytinantti, Heli Viljakainen, Sture Andersson, Outi Mäkitie
BACKGROUND: Vitamin D supplementation is widely recommended for infants, but the optimal dose remains unclear. High intake may result in hypercalcemia. METHODS: We evaluated the incidence of hypercalcemia during the first year of life in a cohort of 987 healthy children who received 10 or 30 μg of vitamin D3 supplementation daily. Ionized calcium (Ca-ion) was analyzed at 6 and 12 months, and serum 25-hydroxyvitamin D (25-OHD) and parathyroid hormone (PTH) concentration at 12 months...
June 23, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28645880/biomarkers-of-airway-and-systemic-inflammation-in-obese-asthmatic-paediatric-patients
#4
H T Nacaroglu, O B Gayret, M Erol, O Buke, O Zengi, M Tasdemir, Z Tasdemir, O Yigit
BACKGROUND: It is thought that airway inflammation is more common in obese asthmatic patients because inflammation is harder to control and does not respond well to glucocorticoid treatment. OBJECTIVE: This study's aim was to investigate the effect of obesity on airway and systemic inflammation in children with asthma and to identify the biomarkers that play a role in this inflammation. METHODS: The study included patients aged 6-16 years who were diagnosed with asthma in the paediatric allergy outpatient clinic of Bagcilar Training and Research Hospital in Turkey...
June 20, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28643993/the-impact-of-vitamin-d-supplementation-on-serum-cathelicidin-levels-and-the-clinical-course-of-atopic-dermatitis-in-children
#5
Kyriaki Tsotra, Anastasia Garoufi, Lydia Kossiva, Dimitrios Gourgiotis, Theano Tsoukatou, Eleni Katsantoni, Panagiotis Stavropoulos
BACKGROUND: Cathelicidin has been correlated with the pathophysiology of atopic dermatitis (AD). An indirect correlation of vitamin D with the course of the disease has already been reported as it directly affects the levels of cathelicidin. The purpose of the present article is to investigate the impact of vitamin D supplementation on the course of AD. METHODS: We conducted a prospective observational study. The severity of AD was assessed with the clinical tool SCORAD (SCORing Atopic Dermatitis) which is developed by the European Task Force on AD...
June 22, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28632934/a-prospective-microbiome-wide-association-study-of-food-sensitization-and-food-allergy-in-early-childhood
#6
Jessica H Savage, Kathleen A Lee-Sarwar, Joanne Sordillo, Supinda Bunyavanich, Yanjiao Zhou, George O'Connor, Megan Sandel, Leonard Bacharier, Robert Zeiger, Erica Sodergren, George M Weinstock, Diane R Gold, Scott T Weiss, Augusto A Litonjua
BACKGROUND: Alterations in the intestinal microbiome are prospectively associated with the development of asthma; less is known regarding the role of microbiome alterations in food allergy development. METHODS: Intestinal microbiome samples were collected at age 3-6 months in children participating in the follow-up phase of an interventional trial of high dose Vitamin D given during pregnancy. At age 3, sensitization to foods (milk, egg, peanut, soy, wheat, walnut) was assessed...
June 20, 2017: Allergy
https://www.readbyqxmd.com/read/28631133/bone-density-in-pediatric-crohn-s-disease-a-cross-sectional-observation-from-south-india
#7
Shiraz Salim Khan, Sagar S Patil
BACKGROUND: Crohn's disease (CD) frequently manifests in the second and third decades of life. Malnutrition and corticosteroid therapy may affect bone mineralization and delay bone growth. Our aim was to study bone mineral density and factors associated low bone mineral density (BMD) in pediatric CD. METHODS: A cross-sectional observational study in children with CD (aged 5 to <18 years) was done. Demographic and treatment details were noted. Vitamin D levels <20 ng/mL were considered as deficiency...
June 20, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28630693/quality-of-food-frequency-questionnaire-validation-studies-in-the-dietary-assessment-of-children-aged-12-to-36-months-a-systematic-literature-review
#8
REVIEW
Amy Lovell, Rhodi Bulloch, Clare R Wall, Cameron C Grant
A child's diet is an important determinant of growth and development. Because of this, the accurate assessment of dietary intake in young children remains a challenge. A systematic search of studies validating FFQ methodologies in children 12 to 36 months of age was completed. English-language articles published until March 2016 were searched using three electronic databases (MEDLINE, EMBASE and CINAHL). Quality assessment of the identified studies was carried out using The Reduced Summary Score and EURopean micronutrient RECommendations Aligned (EURRECA) scoring system...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28628759/do-infants-with-cow-s-milk-protein-allergy-have-inadequate-levels-of-vitamin-d
#9
Cristiane M Silva, Silvia A da Silva, Margarida M de C Antunes, Gisélia Alves Pontes da Silva, Emanuel Sávio Cavalcanti Sarinho, Kátia G Brandt
OBJECTIVE: To verify whether infants with cow's milk protein allergy (CMPA) have inadequate vitamin D levels. METHODS: This cross-sectional study included 120 children aged 2 years or younger, one group with CMPA and a control group. The children were recruited at the pediatric gastroenterology, allergology, and pediatric outpatient clinics of a university hospital in the Northeast of Brazil. A questionnaire was administered to the caregiver and blood samples were collected for vitamin D quantification...
June 16, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28627192/-excess-weight-in-patients-with-cystic-fibrosis-is-it-always-beneficial
#10
David González Jiménez, Rosana Muñoz-Codoceo, María Garriga-García, Manuel Molina-Arias, Marina Álvarez-Beltrán, Ruth García-Romero, Cecilia Martínez-Costa, Silvia María Meavilla-Olivas, Luis Rodrigo Peña-Quintana, Silvia Gallego Gutiérrez, José Manuel Marugán de Miguelsanz, Lucrecia Suárez Cortina, Esperanza Natividad Castejón Ponce, Rosaura Leis Trabazo, Fayna Martín Cruz, Juan José Díaz Martín, Carlos Bousoño García
INTRODUCTION: The primary objective of this study was to find out the prevalence of overweight and obese status, as well as their association to pulmonary function, total cholesterol and vitamin D in patients with cystic fibrosis (CF). MATERIALS AND METHODS: This is a multicenter descriptive and cross-sectional study. Twelve Spanish hospitals participated. 451 patients with CF were included. Adults were classified according to body mass index (BMI) and children were classified according to BMI percentiles (WHO tables)...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28626104/-prevalence-of-vitamin-d-insufficiency-deficiency-among-overweight-and-obese-preschool-children-in-%C3%A2-yuelu-district-of-changsha
#11
Yifu He, Ming Cai, Xin Huang
To investigate the prevalence of vitamin D insufficiency/deficiency among 3-5 years old overweight and obese children in Yuelu district of Changsha and to give scientific suggestion for children health promotion.
 Methods: Based on the stratified cluster sampling method, 2 872 children aged 3-5 years old from Yuelu district were enrolled from Oct to Dec 2015. All participants have received biochemical and physical examination. According to the body mass index, the prevalence rates of vitamin D insufficiency [serum 25(OH)D level 20-<30 ng/mL] and deficiency [serum 25(OH)D level<20 ng/mL] among normal weight, overweight/obese children were calculated, respectively...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28626020/lack-of-effect-of-vitamin-d3-supplementation-in-autism-a-20-week-placebo-controlled-rct
#12
Conor P Kerley, Clare Power, Louise Gallagher, David Coghlan
OBJECTIVES: Data suggest a potential role for vitamin D in autism spectrum disorder (ASD). We wanted to assess the effect of vitamin D3 supplementation compared with placebo in children with ASD. DESIGN: This was a double-blind, randomised, placebo-controlled trial. SETTING: A paediatric outpatient centre at high latitude over the winter season in Dublin, Ireland (53°N). PATIENTS: 42 children with ASD. INTERVENTIONS: 2000 IU vitamin D3 supplementation or placebo daily for 20 weeks...
June 16, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28625040/vitamin-d-status-in-under-five-children-with-a-history-of-close-tuberculosis-contact-in-padang-west-sumatra
#13
Finny Fitry Yani, Nur Indrawaty Lipoeto, Bambang Supriyatno, Eryati Darwin, Darfioes Basir
BACKGROUND AND OBJECTIVE: Serum vitamin D influences cellular immunity against Mycobacterium tuberculosis, particularly in under-five children. Vitamin D insufficiency and deficiency as well as tuberculosis (TB) are highly prevalent in Indonesia. This study described the association of serum vitamin D in the incidence of latent TB in under-five children with a history of close TB contact. METHODS AND STUDY DESIGN: This cross-sectional study examined 178 under-five children with a history of close TB contact, with 98 index cases from primary health care facilities in Padang...
June 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28620062/urine-biomarkers-to-predict-response-to-lupus-nephritis-therapy-in-children-and-young-adults
#14
Hermine I Brunner, Michael R Bennett, Gaurav Gulati, Khalid Abulaban, Marisa S Klein-Gitelman, Stacy P Ardoin, Lori B Tucker, Kelly A Rouster-Stevens, David Witte, Jun Ying, Prasad Devarajan
OBJECTIVE: To delineate urine biomarkers that forecast response to therapy of lupus nephritis (LN). METHODS: Starting from the time of kidney biopsy, patients with childhood-onset systemic lupus erythematosus who were diagnosed with LN were studied serially. Levels of 15 biomarkers were measured in random spot urine samples, including adiponectin, α-1-acid glycoprotein (AGP), ceruloplasmin, hemopexin, hepcidin, kidney injury molecule 1, monocyte chemotactic protein-1, lipocalin-like prostaglandin D synthase (LPGDS), transforming growth factor-β (TGF-β), transferrin, and vitamin D binding protein (VDBP)...
June 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28615961/the-role-of-novel-biomarkers-in-childhood-idiopathic-nephrotic-syndrome-a-narrative-review-of-published-evidence
#15
REVIEW
Samuel N Uwaezuoke
Two histological subtypes of idiopathic nephrotic syndrome are commonly recognized in children, namely minimal change nephropathy and focal segmental glomerulosclerosis. Children with minimal change nephropathy (the majority of whom are steroid-sensitive) and focal segmental glomerulosclerosis (the majority of whom are steroid-resistant) require early identification in order to ensure appropriate therapeutic intervention and better outcome. Although renal biopsy and histology remain the ideal diagnostic steps to identify these histological subtypes, reports indicate that serum and urinary biomarkers are now being utilized in the investigation of childhood idiopathic nephrotic syndrome...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28615261/increased-vitamin-d-intake-differentiated-according-to-skin-color-is-needed-to-meet-requirements-in-young-swedish-children-during-winter-a-double-blind-randomized-clinical-trial
#16
Inger Öhlund, Torbjörn Lind, Olle Hernell, Sven-Arne Silfverdal, Pia Karlsland Åkeson
Background: Dark skin and low exposure to sunlight increase the risk of vitamin D insufficiency in children.Objective: The aim of the study was to evaluate the amount of vitamin D needed to ascertain that most children >4 y of age attain sufficient serum 25-hydroxyvitamin D [S-25(OH)D; i.e., ≥50 nmol/L] during winter regardless of latitude and skin color.Design: In a longitudinal, double-blind, randomized, food-based intervention study, 5- to 7-y-old children from northern (63°N) and southern (55°N) Sweden with fair (n = 108) and dark (n = 98) skin were included...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28608241/vit-d-deficiency-is-a-possible-risk-factor-in-ars
#17
Mustafa Suphi Elbistanlı, Hasan Emre Koçak, Selçuk Güneş, Harun Acıpayam, Baver Maşallah Şimşek, Sinan Canpolat, Fatma Tülin Kayhan
Vitamin D deficiency is effective in the development of acute rhinosinusitis and prolongation of inflammation by increasing inflammation in the sinonasal epithelium. Vitamin D deficiency is important in the development of bone barriers that prevent the complication of acute rhinosinusitis. Although Vitamin D levels may be a variable risk factor for various respiratory tract disorders, there are limited data on the role in sinonasal infections. Our aim was to investigate the association of 25-hydroxy-vitamin D (25OHD) levels with acute rhinosinusitis (ARS) and preseptal cellulitis complications...
June 12, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28607944/vitamin-d-deficient-rickets-in-japan
#18
Mitsuko Itoh, Jun Tomio, Satoshi Toyokawa, Mayuko Tamura, Tsuyoshi Isojima, Sachiko Kitanaka, Yasuki Kobayashi
Objectives: Our study aimed to clarify the trend of vitamin D deficiency and rickets diagnosed in the past 10 years. Methods: This observational study used health insurance claims data from 2005 to 2014. The number of beneficiaries for 2005 and 2014 were 91 617 and 365 800, respectively. We included children aged 0 to 15 years diagnosed with vitamin D deficiency or vitamin D-deficient rickets; those with congenital/secondary rickets and low-birth-weight infants were excluded. We analyzed the number of patients and the temporal trend of these diseases in Japan...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28607175/environmental-factors-explain-socioeconomic-prevalence-differences-in-myopia-in-6-year-old-children
#19
J Willem L Tideman, Jan Roelof Polling, Albert Hofman, Vincent Wv Jaddoe, Johan P Mackenbach, Caroline Cw Klaver
PURPOSE: High myopia (≤-6 D) usually has its onset before 10 years of age and can lead to blinding complications later in life. We examined whether differences in myopia prevalences in socioeconomic risk groups could be explained by differences in lifestyle factors. METHODS: A total of 5711 six-year-old children participating in the prospective population-based birth cohort study Generation R underwent a stepwise ophthalmic examination, which included visual acuity and objective cycloplegic refraction to identify children with myopia (≤-0...
June 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28604131/micronutrient-intake-and-the-contribution-of-dietary-supplements-in-hispanic-infants
#20
Kiara Amaro-Rivera, Andrea López-Cepero, Beatriz Diaz, Jae Eun Lee, Cristina Palacios
To calculate micronutrient adequacy among infants and toddlers and to determine the contribution of dietary supplements to this adequacy, micronutrient intake was assessed using two nonconsecutive 24-hour recalls in a sample of 296 infants aged 0-24 months. Micronutrient intake was calculated from foods and beverages and from supplements and compared between nonusers and users of supplements. Percentages of children below the Dietary Reference Intake (DRI) and above the tolerable upper limit intake (UL) were also compared between groups...
June 12, 2017: Journal of Dietary Supplements
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