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https://www.readbyqxmd.com/read/29150647/impact-of-multidecadal-climate-variability-on-united-kingdom-rickets-rates
#1
Haris Majeed, G W K Moore
Children who receive inadequate exposure to sunlight have reduced levels of vitamin D, resulting in rickets, a disease that is characterized by bone deformity, stunted growth, and long term pronounced disability. The United Kingdom rickets incidence rates declined from the early 1960's to mid-1990's, after which there was a dramatic increase. The reason for this change is not well understood. Here we show that an important low frequency mode of climate variability, the Atlantic Multidecadal Oscillation (AMO), with a period of ~60-80 years, has an impact on rickets incidence rates in the United Kingdom through changes in sea level pressure, cloud cover and sunshine duration...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29143766/assessment-of-micronutrient-status-in-critically-ill-children-challenges-and-opportunities
#2
REVIEW
Duy T Dao, Lorenzo Anez-Bustillos, Bennet S Cho, Zhilling Li, Mark Puder, Kathleen M Gura
Micronutrients refer to a group of organic vitamins and inorganic trace elements that serve many functions in metabolism. Assessment of micronutrient status in critically ill children is challenging due to many complicating factors, such as evolving metabolic demands, immature organ function, and varying methods of feeding that affect nutritional dietary intake. Determination of micronutrient status, especially in children, usually relies on a combination of biomarkers, with only a few having been established as a gold standard...
October 28, 2017: Nutrients
https://www.readbyqxmd.com/read/29143127/decreased-serum-vitamin-b12-and-vitamin-d-levels-affect-sleep-quality-in-children-with-familial-mediterranean-fever
#3
Rabia Miray Kisla Ekinci, Sibel Balci, Mahir Serbes, Dilek Dogruel, Derya Ufuk Altintas, Mustafa Yilmaz
Familial Mediterranean fever is an autoinflammatory disorder characterized by recurrent fever and serositis. We aimed to describe serum vitamin B12 and vitamin D levels and their correlation with self-reported sleep quality of pediatric FMF patients. Sixty-three children with FMF were enrolled to the study. Information on sleep quality was obtained using self-administration of Pittsburg Sleep Quality Index (PSQI). The patients were divided into subgroups depending on vitamin D serum concentrations: ≥ 20 and < 20 ng/ml...
November 15, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29142377/serum-vitamin-d-status-and-outcome-in-critically-ill-children
#4
Nazik Aşılıoğlu, Halit Çiǧdem, Muhammed Sükrü Paksu
Background: Vitamin D is a pleiotropic hormone essential for optimal health. Critical illness in children is a major cause of significant health-care utilization and mortality around the world. The association of Vitamin D deficiency (VDD) in critically ill adults has been well-studied, in comparison, the importance of Vitamin D in pediatric critical illness has been much less studied. Aim and Objectives: This study aimed to assess Vitamin D status and its determinants in patients admitted to a pediatric intensive care unit (PICU) in North of Turkey...
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29141752/differences-in-nutritional-and-health-status-in-school-children-from-the-highlands-and-lowlands-of-bolivia
#5
Graciela Terán, Washington Cuna, Froilán Brañez, Kristina E M Persson, Martín E Rottenberg, Susanne Nylén, Celeste Rodriguez
Children in the Bolivian Andes are exposed to endemic infections and meager nourishment, and live under poor hygienic conditions. The prevention of children malnutrition is a priority in many countries including Bolivia. In this study, the health status of schoolchildren in Taraco, a Puna district, at 4,000 meters above sea level (masl) and in Caranavi, at 650 masl in the wealthier subtropical valleys, was compared. The weight, height, and hematological and biochemical parameters in blood, parasites in stool, and clinical information in 120 children from rural Taraco and in 96 from semi-urban Caranavi, both predominantly of Aymara ethnicity, were registered...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29137132/maternal-vitamin-d-status-and-the-relationship-with-neonatal-anthropometric-and-childhood-neurodevelopmental-outcomes-results-from-the-seychelles-child-development-nutrition-study
#6
Eamon Laird, Sally W Thurston, Edwin van Wijngaarden, Conrad F Shamlaye, Gary J Myers, Philip W Davidson, Gene E Watson, Emeir M McSorley, Maria S Mulhern, Alison J Yeates, Mary Ward, Helene McNulty, J J Strain
Vitamin D has an important role in early life; however, the optimal vitamin D status during pregnancy is currently unclear. There have been recent calls for pregnant women to maintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yet little is known about the long-term potential benefits or safety of achieving such high maternal 25(OH)D concentrations for infant or child health outcomes. We examined maternal vitamin D status and its associations with infant anthropometric and later childhood neurocognitive outcomes in a mother-child cohort in a sun-rich country near the equator (4...
November 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29135286/vitamin-b12-supplementation-influences-methylation-of-genes-associated-with-type-2-diabetes-and-its-intermediate-traits
#7
Dilip K Yadav, Smeeta Shrestha, Karen A Lillycrop, Charu V Joglekar, Hong Pan, Joanna D Holbrook, Caroline Hd Fall, Chittaranjan S Yajnik, Giriraj R Chandak
AIM: To investigate the effect of B12 and/or folic acid supplementation on genome-wide DNA methylation. METHODS: We performed Infinium HumanMethylation450 BeadChip (Zymo Research, CA, USA) assay in children supplemented with B12 and/or folic acid (n = 12 in each group) and investigated the functional mechanism of selected differentially methylated loci. RESULTS: We noted significant methylation changes postsupplementation in B12 (589 differentially methylated CpGs and 2892 regions) and B12 + folic acid (169 differentially methylated CpGs and 3241 regions) groups...
November 14, 2017: Epigenomics
https://www.readbyqxmd.com/read/29132463/-serum-levels-of-25-hydroxyvitamin-d-in-children-with-tic-disorders
#8
Hong-Hua Li, Bing Wang, Ling Shan, Cheng-Xin Wang, Fei-Yong Jia
OBJECTIVE: To examine serum 25-hydroxyvitamin D levels in children with tic disorders (TD) and to explore the relationship between vitamin D level and TD. METHODS: One hundred and thirty-two children who were diagnosed with TD between November 2016 and May 2017 were enrolled as the TD group, including 8 cases of Tourette syndrome, 32 cases of chronic TD, and 92 cases of transient TD. One hundred and forty-four healthy children served as the control group. Peripheral venous blood samples were collected from each child...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29128760/vitamin-d-deficiency-in-children-with-recurrent-respiratory-infections-with-or-without-immunoglobulin-deficiency
#9
Nel Dąbrowska-Leonik, Ewa Bernatowska, Małgorzata Pac, Wiktor Filipiuk, Jan Mulawka, Barbara Pietrucha, Edyta Heropolitańska-Pliszka, Katarzyna Bernat-Sitarz, Beata Wolska-Kuśnierz, Bożena Mikołuć
PURPOSE: The objective of this study was to evaluate thevitamin D concentration in patients with recurrent respiratory infections with or without immunoglobulin G, A or M (IgG, IgA, IgM) deficiency, and to find a correlation between the vitamin D concentration and the response to hepatitis B vaccination. MATERIALS AND METHOD: The study involved 730 patients with recurrent respiratory infections. The concentration of 25-hydroxyvitamin D (25(OH)D), immunoglobulins G, A and M, anti-HBs was determined...
November 9, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29125452/prevalence-and-risk-factors-of-vitamin-d-insufficiency-and-deficiency-among-6-24-month-old-underweight-and-normal-weight-children-living-in-an-urban-slum-of-bangladesh
#10
Am Shamsir Ahmed, Tahmeed Ahmed, Kurt Z Long, Ricardo J Soares Magalhaes, Md Iqbal Hossain, Md Munirul Islam, Mustafa Mahfuz, Sm Abdul Gaffar, Atiya Sharmeen, Rashidul Haque, Richard L Guerrant, William A Petri, Abdullah Al Mamun
OBJECTIVE: We quantified the prevalence of vitamin D status in 6-24-month-old underweight and normal-weight children and identified the socio-economic and dietary predictors for status. DESIGN: Cross-sectional, baseline data from a nutritional intervention study were analysed. Multinomial logistic regression was used to estimate the odds of being vitamin D deficient or insufficient with the reference being vitamin D sufficient. SETTING: Urban slum area of Mirpur field site, Dhaka, Bangladesh...
July 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29123343/multiple-nutritional-deficiencies-in-cerebral-palsy-compounding-physical-and-functional-impairments
#11
P G Hariprasad, K E Elizabeth, Mathew J Valamparampil, D Kalpana, T S Anish
Introduction: Cerebral palsy (CP) refers to a spectrum of disorders causing physical and intellectual morbidity. Macro and micro nutrient deficiencies often contribute to the subnormal physical and mental capabilities of them. Objectives: To assess the growth, nutritional status, physical and functional ability and quality of life in cerebral palsy children and to determine any relation with their gross motor and functional capabilities. Method: The study was conducted at a Tertiary Care Centre, with the participants in the age group 1-16 years...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29122496/determinants-of-low-bone-mineral-density-in-children-with-epilepsy
#12
Choong Yi Fong, Ann Nie Kong, Mazidah Noordin, Bee Koon Poh, Lai Choo Ong, Ching Ching Ng
INTRODUCTION: Children with epilepsy on long-term antiepileptic drugs (AEDs) are at risk of low bone mineral density (BMD). The aims of our study were to evaluate the prevalence and determinants of low BMD among Malaysian children with epilepsy. METHOD: Cross-sectional study of ambulant children with epilepsy on long-term AEDs for >1 year seen in a tertiary hospital in Malaysia from 2014 to 2015. Detailed assessment of anthropometric measurements; environmental lifestyle risk factors; serum vitamin D, calcium and parathyroid hormone levels; genotyping of single nucleotide polymorphisms of genes in vitamin D and calcium metabolism; and lumbar spine BMD were obtained...
October 24, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29119026/thiamine-deficiency-leading-to-refractory-lactic-acidosis-in-a-pediatric-patient
#13
Alicia M Teagarden, Brian D Leland, Courtney M Rowan, Riad Lutfi
Thiamine plays a critical role in energy metabolism. Critically ill children and adults may develop thiamine deficiency with ultimately increased mortality due to potentially irreversible consequences of severe type B lactic acidosis. We report a case of an unvaccinated term neonate with malignant pertussis requiring extracorporeal membrane oxygenation and continuous renal replacement therapy, who developed profound lactic acidosis of unknown etiology. After countless evaluations for likely causes, the patient was ultimately determined to have thiamine deficiency and her acidosis resolved rapidly with vitamin supplementation...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29117188/potential-of-golden-potatoes-to-improve-vitamin-a-and-vitamin-e-status-in-developing-countries
#14
Chureeporn Chitchumroonchokchai, Gianfranco Diretto, Bruno Parisi, Giovanni Giuliano, Mark L Failla
Potato (Solanum tuberosum L.) is the third most widely consumed plant food by humans. Its tubers are rich in starch and vitamin C, but have low or null levels of essential nutrients such as provitamin A and vitamin E. Transformation of potato with a bacterial mini-pathway for β-carotene in a tuber-specific manner results in a "golden" potato (GP) tuber phenotype resulting from accumulation of provitamin A carotenoids (α- and β-carotene) and xanthophylls. Here, we investigated the bioaccessibility of carotenoids and vitamin E as α-tocopherol (αTC) in boiled wild type and golden tubers using in vitro digestion...
2017: PloS One
https://www.readbyqxmd.com/read/29112476/cross-sectional-evaluation-of-plasma-vitamin-d-levels-in-a-large-cohort-of-italian-patients-with-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections
#15
Stefano Stagi, Gemma Lepri, Donato Rigante, Marco Matucci Cerinic, Fernanda Falcini
BACKGROUND: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are immune-mediated diseases characterized by obsessive-compulsive symptoms and/or tics triggered by group A Streptococcus infections. Despite the well-known action of 25-hydroxyvitamin D [25(OH)D] on different conditions driven by systemic inflammation, there are no data about the 25(OH)D status in patients with PANDAS. AIMS: To evaluate plasma 25(OH)D levels in a large cohort of children and adolescents with PANDAS and comparing the results with healthy controls...
November 7, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29111213/prenatal-and-early-life-triclosan-and-parabens-exposure-and-allergic-outcomes
#16
Kathleen Lee-Sarwar, Russ Hauser, Antonia M Calafat, Xiaoyun Ye, George T O'Connor, Megan Sandel, Leonard B Bacharier, Robert S Zeiger, Nancy Laranjo, Diane R Gold, Scott T Weiss, Augusto A Litonjua, Jessica H Savage
BACKGROUND: In cross-sectional studies, triclosan and parabens, ubiquitous ingredients in personal care and other products, are associated with allergic disease. OBJECTIVES: We investigated the association between prenatal and early life triclosan and parabens exposure and childhood allergic disease in a prospective, longitudinal study. METHODS: Subjects were enrollees in VDAART, the Vitamin D Antenatal Asthma Reduction Trial. Triclosan, methyl paraben and propyl paraben concentrations were quantified in maternal plasma samples pooled from first and third trimesters and urine samples from children at age 3 or 4 years...
October 27, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29108191/-an-interpretation-of-the-aasld-practice-guideline-on-the-diagnosis-and-management-of-nonalcoholic-fatty-liver-disease-in-2017
#17
Y M Nan, N Fu, W C Li, L L Kong, X W Yuan, S Y Zhang, L D Liu, Y Lu, L Y Cui
The American Association for the Study of Liver Diseases (AASLD) updated and published the Practice Guidance for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease (NAFLD) in July 2017, which provides recommendations for the accurate diagnosis, treatment, and effective prevention of NAFLD. Related metabolic diseases should be considered during the initial evaluation of patients suspected of NAFLD. Noninvasive diagnostic techniques including transient elastography, magnetic resonance elastography, and serum biochemical models should be used to evaluate the development and progression of liver fibrosis in patients with NAFLD...
September 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29101669/25oh-vitamin-d-levels-in-pediatric-patients-affected-by-prader-willi-syndrome
#18
D Fintini, S Pedicelli, S Bocchini, C Bizzarri, G Grugni, M Cappa, A Crinò
PURPOSE: Obesity, insulin resistance, and puberty seem to influence and been inversely associated with 25-hydroxy vitamin D (25OHD) levels. To our knowledge, a study on 25OHD in children and adolescents with Prader-Willi syndrome (PWS), a genetic form of obesity, is not yet available. OBJECTIVE: To analyze the 25OHD values in pediatric PWS subjects in comparison with a control group (CNT), highlighting the possible correlations with IR, BMD, body composition, pubertal stage, and GH therapy (GHT)...
November 3, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29101654/inflammatory-bowel-disease-effects-on-bone-and-mechanisms
#19
Francisco A Sylvester
Inflammatory bowel disease (IBD) is associated with decreased bone mass and alterations in bone geometry from the time of diagnosis, before anti-inflammatory therapy is instituted. Deficits in bone mass can persist despite absence of symptoms of active IBD. The effects of IBD on the skeleton are complex. Protein-calorie malnutrition, inactivity, hypogonadism, deficits in calcium intake and vitamin D consumption and synthesis, stunted growth in children, decreased skeletal muscle mass, and inflammation all likely play a role...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29099735/effect-of-pharmacogenetic-markers-of-vitamin-d-pathway-on-deferasirox-pharmacokinetics-in-children
#20
Sarah Allegra, Jessica Cusato, Silvia De Francia, Filomena Longo, Elisa Pirro, Davide Massano, Antonio Piga, Antonio D'Avolio
OBJECTIVES: Patients with β-thalassemia major have extremely low vitamin D levels, owing to reduced intestinal absorption, subicteric tint, and/or iron-induced higher pigmentation. We investigated whether some polymorphisms within the VDR, CYP24A1, CYP27B1, and GC genes could play a role in deferasirox pharmacokinetics in a cohort of pediatric patients. PATIENTS AND METHODS: Eighteen children with β-thalassemia were enrolled. Drug plasma concentrations at the end of dosing interval (Ctrough) and after 0, 2, 4, 6, and 24 h of drug administration were measured by a HPLC-UV method...
November 2, 2017: Pharmacogenetics and Genomics
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