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Cancer tumor oncology NCCN radiotherapy

Vassilis Kouloulias, Sotiria Triantopoulou, Nikolaos Uzunoglou, Kyriaki Pistevou-Gompaki, Alfred Barich, Anna Zygogianni, George Kyrgias, Dimitris Kardamakis, Dimitris Pectasidis, John Kouvaris
BACKGROUND: Hyperthermia has been included in the 2013 National Comprehensive Cancer Network (NCCN) guidelines as an option for the treatment of breast recurrences. The purpose of this article is to demonstrate the important role of hyperthermia as a therapeutic modality by presenting clinical trials on this subject carried out in the last decades. MATERIALS AND METHODS: All relevant trials published since 1987 were retrieved from Medline and reviewed. RESULTS: Results show that the addition of hyperthermia to radiotherapy and/or chemotherapy for the treatment of breast cancer enhances treatment response and can increase local control...
April 2015: Breast Care
Nikoletta Dimitriou, Othon Michail, Dimitrios Moris, John Griniatsos
Low rectal cancer is traditionally treated by abdominoperineal resection. In recent years, several new techniques for the treatment of very low rectal cancer patients aiming to preserve the gastrointestinal continuity and to improve both the oncological as well as the functional outcomes, have been emerged. Literature suggest that when the intersphincteric resection is applied in T1-3 tumors located within 30-35 mm from the anal verge, is technically feasible, safe, with equal oncological outcomes compared to conventional surgery and acceptable quality of life...
July 15, 2015: World Journal of Gastrointestinal Oncology
Jashodeep Datta, Matthew T McMillan, Eric K Shang, Ronac Mamtani, Russell S Lewis, Rachel R Kelz, Ursina Teitelbaum, John P Plastaras, Jeffrey A Drebin, Douglas L Fraker, Giorgos C Karakousis, Robert E Roses
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Gastric Cancer recommend adjuvant chemotherapy with or without radiotherapy following after resection of gastric adenocarcinoma (GA) for patients who have not received neoadjuvant therapy. Despite frequent noncompliance with NCCN Guidelines nationally, risk factors underlying adjuvant therapy omission (ATom) have not been well characterized. We developed an internally validated preoperative instrument stratifying patients by incremental risk of ATom...
May 2015: Journal of the National Comprehensive Cancer Network: JNCCN
M O Adameșteanu, V Enache, D Zamfirescu, I Lascăr
In medical practice, plastic surgeons confront with patients with sarcomas of the extremities that require a radical surgical approach. Knowing when to attempt limb-sparing surgery and when to give in to limb amputation is one of the most difficult decisions a surgeon can take. The correct approach and management of such cases ensure surgical success and the patient survival. In this paper, the case of a 56-year-old man, admitted in our clinic with a crush injury of the right calf and subsequent haematoma is presented...
April 2015: Journal of Medicine and Life
F Couñago, M Recio, E Del Cerro, L Cerezo, A Díaz Gavela, F J Marcos, R Murillo, J M Rodriguez Luna, I J Thuissard, J L R Martin
PURPOSE: To evaluate the accuracy of preoperative 3T multiparametric magnetic resonance imaging (3TmMRI) for local staging of prostate cancer and its influence on the decision to change the clinical target volume (CTV), total dose and hormonal therapy when treating prostate cancer patients with radiotherapy. METHODS: From 2009 to 2013, 150 patients, who had confirmed prostate cancer and underwent a 3TmMRI before treatment with radical prostatectomy or radical radiation therapy, were included...
November 2014: Clinical & Translational Oncology
Marsha Reyngold, Joyce Niland, Anna ter Veer, Dana Milne, Tanios Bekaii-Saab, Steven J Cohen, Lily Lai, Deborah Schrag, John M Skibber, William Small, Martin Weiser, Neal Wilkinson, Karyn A Goodman
Based on randomized data, neoadjuvant chemoradiotherapy has been incorporated into the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for stage II-III rectal cancer. Factors associated with nonadherence to evidence-based guidelines for neoadjuvant radiotherapy (RT) were examined at dedicated cancer centers. The prospective NCCN Oncology Outcomes Database for Colorectal Cancers was queried for patients with stage II-III rectal cancer who underwent a transabdominal surgical resection between September 2005 and June 2012...
February 2014: Journal of the National Comprehensive Cancer Network: JNCCN
Giuseppe Ferrera, Giovanni Caminiti, Antonietta Grillo, Filippo Alongi, Giovanna Evangelista, Emanuela Greco, Teresa Cucchiara, Michele Bono, Gianluca Mortellaro, Antonio Cirrincione, Francesca Dalia, Giuseppina Iacoviello, Vittorio Caputo, Massimo Midiri, Francesco Sciumè
AIMS: To evaluate long-term late side effects, clinical and biochemical relapse in non-metastatic prostate cancer patients treated with dose escalation, from 74 to 78 Gy, by means of three dimensional conformal radiation therapy. MATERIALS AND METHODS: Clinical data of 125 patients with prostate cancer who underwent three-dimensional conformal radiation therapy were retrospectively evaluated. All patients were stratified, according to the NCCN classification, in low, intermediate and high risk, and all of them showed histologically proven adenocarcinoma stage T1-T3 with at least 2 years of follow-up...
November 2013: Tumori
Jie Chen, Qing Lü, Xiaodong Wang, Hongjiang Li, Yujuan Chen, Xiaoqin Yang, Helin Zeng
OBJECTIVE: To evaluate the feasibility, oncological safety, and aesthetic result of skin-spring mastectomy (SSM) or nipple-spring mastectomy (NSM) in breast reconstruction of implant (permanent gel or expander) for breast cancer patients who were not fit for the breast conserving surgery (BCS). METHODS: Between October 2005 and July 2011, 89 women with breast caner underwent SSM or NSM, with an average age of 42.4 years (range, 19-55 years) and an average disease duration of 5...
July 2013: Chinese Journal of Reparative and Reconstructive Surgery
Vlad C Sandulache, Mark W Kubik, Heath D Skinner, Joseph A Malsky, Alexander H Gelbard, Jose P Zevallos
OBJECTIVES/HYPOTHESIS: Black patients generally present with advanced head and neck cancer resulting in decreased survival. The objective of this study was to determine whether equal access to laryngeal cancer care in a tertiary care Veterans Affairs (VA) Medical Center would result in similar survival for white and black patients. STUDY DESIGN: Retrospective chart review. METHODS: Patient and tumor characteristics, compliance with National Comprehensive Cancer Network (NCCN) guidelines, and survival outcomes were collected for 205 male patients with squamous cell carcinoma of the larynx treated between 2000 and 2012 at the Michael E...
September 2013: Laryngoscope
Jonathan W Riess, Seema Nagpal, Joel W Neal, Heather A Wakelee
Leptomeningeal carcinomatosis (LM) is an infrequent yet morbid and often fatal complication of non-small cell lung cancer (NSCLC). Management of LM is multimodal, often involving systemic chemotherapy, radiotherapy, and a variety of symptom management maneuvers to address elevated intracranial pressure, pain, and mood changes that can accompany the disease. It is increasingly recognized that tumors with actionable mutations in NSCLC, including epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) translocations, respond well to systemic therapy with tyrosine kinase inhibitors yet often progress in the central nervous system...
April 1, 2013: Journal of the National Comprehensive Cancer Network: JNCCN
Arun Sharma, Stephen M Schwartz, Eduardo Méndez
BACKGROUND: Given the complexity of management of advanced head and neck squamous cell carcinoma (HNSCC), this study hypothesized that high hospital volume would be associated with receiving National Comprehensive Cancer Network (NCCN) guideline therapy and improved survival in patients with advanced HNSCC. METHODS: The Surveillance, Epidemiology, and End Results (SEER)-Medicare database was used to identify patients with advanced HNSCC. Treatment modalities and survival were determined using Medicare data...
May 15, 2013: Cancer
Gregory P Kalemkerian, Wallace Akerley, Paul Bogner, Hossein Borghaei, Laura Qm Chow, Robert J Downey, Leena Gandhi, Apar Kishor P Ganti, Ramaswamy Govindan, John C Grecula, James Hayman, Rebecca Suk Heist, Leora Horn, Thierry Jahan, Marianna Koczywas, Billy W Loo, Robert E Merritt, Cesar A Moran, Harvey B Niell, Janis O'Malley, Jyoti D Patel, Neal Ready, Charles M Rudin, Charles C Williams, Kristina Gregory, Miranda Hughes
Neuroendocrine tumors account for approximately 20% of lung cancers; most (≈15%) are small cell lung cancer (SCLC). These NCCN Clinical Practice Guidelines in Oncology for SCLC focus on extensive-stage SCLC because it occurs more frequently than limited-stage disease. SCLC is highly sensitive to initial therapy; however, most patients eventually die of recurrent disease. In patients with extensive-stage disease, chemotherapy alone can palliate symptoms and prolong survival in most patients; however, long-term survival is rare...
January 1, 2013: Journal of the National Comprehensive Cancer Network: JNCCN
Polina Khrizman, Joyce C Niland, Anna ter Veer, Dana Milne, Kelli Bullard Dunn, William E Carson, Paul F Engstrom, Stephen Shibata, John M Skibber, Martin R Weiser, Deborah Schrag, Al B Benson
PURPOSE: Practice guidelines recommend that patients who receive neoadjuvant chemotherapy and radiation for locally advanced rectal cancer complete postoperative adjuvant systemic chemotherapy, irrespective of tumor downstaging. PATIENTS AND METHODS: The National Comprehensive Cancer Network (NCCN) Colorectal Cancer Database tracks longitudinal care for patients treated at eight specialty cancer centers across the United States and was used to evaluate how frequently patients with rectal cancer who were treated with neoadjuvant chemotherapy also received postoperative systemic chemotherapy...
January 1, 2013: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Chul Young Chang, Hee Cheol Kim, Young Suk Park, Joon Oh Park, Doo Ho Choi, Hee Chul Park, Yong Beom Cho, Seong Hyeon Yun, Woo Yong Lee, Ho-Kyung Chun
BACKGROUND AND OBJECTIVES: The 2010 NCCN clinical practice guidelines recommend radiation as a part of the standard adjuvant or neoadjuvant treatment for stage IV rectal cancer patients. This study evaluated the oncologic efficacy of postoperative radiotherapy (RTx) in loco-regional control after complete removal of primary and metastatic lesions in stage IV rectal cancer. METHODS: Sixty-eight patients with metastatic rectal cancer were enrolled and analyzed. Twenty-eight of the enrolled patients received concurrent postoperative RTx with chemotherapy (RTx group) and the remaining 40 received only postoperative systemic chemotherapy (CTx) without RTx (non-RTx group)...
March 2012: Journal of Surgical Oncology
Costanza Chiumento, Antonietta Montagna, Stefania Clemente, Mariella Cozzolino, Vincenzo Fusco
AIMS AND BACKGROUND: To evaluate the biochemical disease-free survival (bDFS) rate after (125)I permanent-implant prostate brachytherapy. METHODS: Patients with a diagnosis of prostate adenocarcinoma and adequate PSA follow-up were selected for this retrospective study. Brachytherapy with permanent (125)I seeds was performed as monotherapy, with a prescribed dose of 145 Gy to the prostate. Patients were stratified into recurrence risk groups according to the National Comprehensive Cancer Network (NCCN) guidelines...
May 2011: Tumori
Enrico Cortesi, Alessandro Tuzi, Daniela Musio
PURPOSE: The determination of the best therapeutic approach in extraperitoneal rectal cancer patients is very complex both in the neoadjuvant/adjuvant and the metastatic setting. We tried to identify and summarize the current methods of diagnosis, staging and treatment from a multidisciplinary approach. METHODS: Five sections can be indentified: diagnosis and staging; neoadjuvant treatment; adjuvant treatment; liver metastases treatment and local recurrence therapy Data were collected from international guidelines (NCCN) and MEDLINE search...
July 2010: Annali Italiani di Chirurgia
Omalkhair Abulkhair, Nagi Saghir, Lobna Sedky, Ahmed Saadedin, Heba Elzahwary, Neelam Siddiqui, Mervat Al Saleh, Fady Geara, Nuha Birido, Nadia Al-Eissa, Sana Al Sukhun, Huda Abdulkareem, Menar Mohamed Ayoub, Fawaz Deirawan, Salah Fayaz, Alaa Kandil, Sami Khatib, Mufid El-Mistiri, Dorria Salem, El Siah Hassan Sayd, Mohammed Jaloudi, Mohammad Jahanzeb, William I Gradishar
Published data from the Middle East and North Africa (MENA) region indicate suboptimal quality of cancer care, while the World Health Organization predicts an increase in cancer cases in developing countries. Major advances in breast cancer management mandate the development of guidelines to improve the quality and efficacy of oncology practice in the MENA region. A Breast Cancer Regional Guidelines Committee was organized and activated, comprising experts from various regional cancer institutions. The multidisciplinary team included 12 medical oncologists, 3 radiation oncologists, 2 radiologists, 2 surgeons, and 1 pathologist...
July 2010: Journal of the National Comprehensive Cancer Network: JNCCN
Waleed A Hassen, Farrok A Karsan, Farhat Abbas, Yasar Beduk, Ahmed El-Khodary, Marwan Ghosn, Jamal Khader, Raja Khauli, Danny M Rabah, Ali Shamseddine, Sandy Srinivas
A prostate cancer committee was established to modify the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) on Prostate Cancer for adaptation and implementation in the Middle East and North Africa (MENA) region. The objective was to enhance the multidisciplinary approach to the treatment of prostate cancer. The committee, comprising regional experts in the fields of urologic, medical, and radiation oncology, reviewed the 2009 version of the NCCN Guidelines on Prostate Cancer and suggested modifications based on the unique needs of the regions determined through published evidence and local expertise...
July 2010: Journal of the National Comprehensive Cancer Network: JNCCN
Serena Ricciardi, Filippo de Marinis
Approximately 30-40% of NSCLC patients develop bone metastases. Bone metastases are associated with a significant increase in skeletal-related events (SREs), including severe bone pain, hypercalcemia, pathological fractures, spinal cord compression. These SREs result in impaired mobility, reduced quality of life, and frequently require therapeutic intervention (radiation therapy, surgery and systemic treatments). The normal balance of formation of new bone by osteoblasts and the resorption of old bone by osteoclasts becomes imbalanced and/or uncoupled, leading to the development of lesions that are osteolytic, osteoblastic, or a combination of both...
September 2009: Reviews on Recent Clinical Trials
Robert L Foote
PURPOSE: To describe and illustrate examples of early-stage larynx and hypopharynx cancer that can be successfully treated with radiotherapy alone. METHODS AND MATERIALS: Review of the NCCN and ASCO practice guidelines. Representative examples are included. RESULTS: Early-stage larynx and hypopharynx cancer is defined by tumor extent based on physical and imaging examination. CONCLUSIONS: Radiotherapy alone is appropriate treatment for properly selected early-stage squamous cell carcinoma of the larynx and hypopharynx...
2007: International Journal of Radiation Oncology, Biology, Physics
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